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247 results on '"Mansueto, Giovanna"'

2. What Does Atypical Chronic Lymphocytic Leukemia Really Mean? A Retrospective Morphological and Immunophenotypic Study

Author

D’Arena, Giovanni, primary, Vitale, Candida, additional, Pietrantuono, Giuseppe, additional, Villani, Oreste, additional, Mansueto, Giovanna, additional, D’Auria, Fiorella, additional, Statuto, Teodora, additional, D’Agostino, Simona, additional, Sabetta, Rosalaura, additional, Tarasco, Angela, additional, Innocenti, Idanna, additional, Autore, Francesco, additional, Fresa, Alberto, additional, Valvano, Luciana, additional, Tomasso, Annamaria, additional, Cafaro, Lorenzo, additional, Lamorte, Daniela, additional, and Laurenti, Luca, additional

Published
2024
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3. T-Large Granular Lymphocytic Leukemia with Hepatosplenic T-Cell Lymphoma? A Rare Case of Simultaneous Neoplastic T-Cell Clones Highlighted by Flow Cytometry and Review of Literature.

Author

Libonati, Rossana, Soda, Michela, Statuto, Teodora, Valvano, Luciana, D'Auria, Fiorella, D'Arena, Giovanni, Pietrantuono, Giuseppe, Villani, Oreste, Mansueto, Giovanna Rosaria, D'Agostino, Simona, Di Somma, Massimo Dante, Telesca, Alessia, and Vilella, Rocchina

Subjects
LYMPHOCYTIC leukemia, T-cell lymphoma, LITERATURE reviews, FLOW cytometry, MOLECULAR cloning
Abstract

Lymphoproliferative diseases are a heterogeneous set of malignant clonal proliferations of lymphocytes. Despite well-established diagnostic criteria, the diagnosis remains difficult due to their variety in clinical presentation and immunophenotypic profile. Lymphoid T-cell disorders are less common than B-cell entities, and the lack of a clear immunophenotypic characteristic makes their identification hard. Flow cytometry turned out to be a useful tool in diagnosing T-cell disorders and to resolve complicated cases, especially if the number of analyzable neoplastic cells is small. We present a case of a 55-year-old man with simultaneous lymphoproliferative neoplastic T-cell clones, one αβ and the other γδ, identified and characterized by flow cytometry (FC), exploiting the variable expression intensity of specific markers. However, the patient's rapid decline made it impossible to define a differential diagnosis in order to confirm the identity of the γδ clone, which remains uncertain. This case is added to the few other cases already documented in the literature, characterized by the co-existence of T-large granular lymphocytic leukemia (T-LGLL)-αβ and T-LGLL-γδ/Hepatosplenic T-cell lymphoma (HSTCL). Our case underlines the key role of sensitive diagnostic tools in the assessment of potential relationship between the diagnosis, prognosis, and treatment in the two pathologies. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Outcome of very elderly chronic myeloid leukaemia patients treated with imatinib frontline

Author

Crugnola, Monica, Castagnetti, Fausto, Breccia, Massimo, Ferrero, Dario, Trawinska, Malgorzata Monika, Abruzzese, Elisabetta, Annunziata, Mario, Stagno, Fabio, Tiribelli, Mario, Binotto, Gianni, Bonifacio, Massimiliano, Fava, Carmen, Iurlo, Alessandra, Bucelli, Cristina, Mansueto, Giovanna, Gozzini, Antonella, Falzetti, Franca, Montefusco, Enrico, Crisà, Elena, Gugliotta, Gabriele, Russo, Sabina, Cedrone, Michele, RussoRossi, Antonella, Pregno, Patrizia, Isidori, Alessandro, Mauro, Endri, Atelda, Romano, Giglio, Gianfranco, Celesti, Francesca, Sorà, Federica, Storti, Sergio, D’Addosio, Adam, Galimberti, Sara, Orlandi, Ester, Calistri, Elisabetta, Bocchia, Monica, Cavazzini, Francesco, Rege Cambrin, Giovanna, Orofino, Nicola, Luciano, Luigiana, Sgherza, Nicola, Rosti, Gianantonio, Latagliata, Roberto, and Capodanno, Isabella

Published
2019
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5. Is re-challenge still an option as salvage therapy in multiple myeloma? The case of REal-life BOrtezomib re-Use as secoND treatment for relapsed patients exposed frontline to bortezomib-based therapies (the REBOUND Study)

Author

Musto, Pellegrino, Simeon, Vittorio, Cascavilla, Nicola, Falcone, Antonietta, Petrucci, Maria Teresa, Cesini, Laura, Di Raimondo, Francesco, Conticello, Concetta, Ria, Roberto, Catalano, Lucio, Salvatore, Dalila, Mastrullo, Lucia, Gagliardi, Alfredo, Villani, Oreste, Pietrantuono, Giuseppe, D’Arena, Giovanni, Mansueto, Giovanna, Bringhen, Sara, Genuardi, Mariella, Di Renzo, Nicola, Reddiconto, Giovanni, Fragasso, Alberto, Caravita, Tommaso, Scapicchio, Daniele, Marziano, Gioacchino, Boccadoro, Mario, Mangiacavalli, Silvia, and Corso, Alessandro

Published
2019
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6. P1208: TRANSCRIPTOMIC PROFILING OF B CELL STATES AND MICROENVIROMENTAL ECOSYSTEMS REFINES THE PROGNOSTIC CLASSIFICATION OF DIFFUSE LARGE B CELL LYMPHOMA

Author

Papotti, Robel, primary, Vit, Filippo, additional, Pozzo, Federico, additional, Bittolo, Tamara, additional, Bettelli, Stefania, additional, Pozzi, Samantha, additional, Maiorana, Antonino, additional, Forti, Elisa, additional, Napoli, Arianna DI, additional, Christina Cox, Maria, additional, Tadmor, Tamar, additional, Mansueto, Giovanna, additional, Musto, Pellegrino, additional, Flenghi, Leonardo, additional, Quintini, Martina, additional, Lalinga, Vittoria, additional, Galimberti, Sara, additional, Donati, Valentina, additional, Spina, Michele, additional, Zamò, Alberto, additional, Rosenwald, Andreas, additional, Bomben, Riccardo, additional, Sacchi, Stefano, additional, and Gattei, Valter, additional

Published
2023
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7. What Does Atypical Chronic Lymphocytic Leukemia Really Mean? A Retrospective Morphological and Immunophenotypic Study.

Author

D'Arena, Giovanni, Vitale, Candida, Pietrantuono, Giuseppe, Villani, Oreste, Mansueto, Giovanna, D'Auria, Fiorella, Statuto, Teodora, D'Agostino, Simona, Sabetta, Rosalaura, Tarasco, Angela, Innocenti, Idanna, Autore, Francesco, Fresa, Alberto, Valvano, Luciana, Tomasso, Annamaria, Cafaro, Lorenzo, Lamorte, Daniela, and Laurenti, Luca

Subjects
CHRONIC lymphocytic leukemia, FLOW cytometry, RETROSPECTIVE studies, ACQUISITION of data, CANCER patients, GENE expression, SYMPTOMS, MEDICAL records, IMMUNOPHENOTYPING, TUMOR markers, PHENOTYPES
Abstract

Simple Summary: Chronic lymphocytic leukemia (CLL) may be atypical in terms of the cell morphology picture, but also with regard to the surface immunophenotypic profile. Aiming at assessing the impact of morphology and immunophenotype in defining the atypical characteristics of CLL in terms of clinical–biological features and prognosis, a retrospective analysis of a large cohort of CLL patients was performed. We found that morphology better predicts the prognosis of atypical CLL compared to immunophenotypic analysis. Also, discordant cases in terms of immunophenotype and morphology did not identify specific prognostic groups. Overall, the question that still needs to be answered is: does it make sense to focus on morphology and immunophenotypic features in CLL in the era of molecular markers used as prognostic indicators? Atypical chronic lymphocytic leukemia (CLL) is still defined according to morphological criteria. However, deviance from the typical surface immunological profile suggests an atypical immunological-based CLL. A large cohort of patients with CLL was retrospectively evaluated aiming at assessing morphological (FAB criteria), immunophenotypical (two or more discordances from the typical profile), and clinical–biological features of atypical CLL. Compared to typical cases, morphologically atypical CLL showed a greater percentage of unmutated IgVH and CD38 positivity, and a higher expression of CD20. Immunophenotypically atypical CLL was characterized by more advanced clinical stages, higher expression of CD20, higher rate of FMC7, CD79b and CD49d positivity, and by an intermediate–high expression of membrane surface immunoglobulin, compared to typical cases. When patients were categorized based on immunophenotypic and morphologic concordance or discordance, no difference emerged. Finally, morphological features better discriminated patients' prognosis in terms of time-to-first treatment, while concordant atypical cases showed overall a worse prognosis. Discordant cases by immunophenotype and/or morphology did not identify specific prognostic groups. Whether—in the era of molecular markers used as prognostic indicators—it does make sense to focus on morphology and immunophenotype features in CLL is still matter of debate needing further research. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Preliminary analysis of double‐negative T, double‐positive T, and natural killer T‐like cells in B‐cell chronic lymphocytic leukemia

Author

Valvano, Luciana, primary, Nozza, Filomena, additional, D'Arena, Giovanni, additional, D'Auria, Fiorella, additional, De Luca, Luciana, additional, Pietrantuono, Giuseppe, additional, Mansueto, Giovanna, additional, Villani, Oreste, additional, D'Agostino, Simona, additional, Lamorte, Daniela, additional, Calice, Giovanni, additional, and Statuto, Teodora, additional

Published
2023
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9. MicroRNA-155 in serum-derived extracellular vesicles as a potential biomarker for hematologic malignancies - a short report

Author

Caivano, Antonella, La Rocca, Francesco, Simeon, Vittorio, Girasole, Marco, Dinarelli, Simone, Laurenzana, Ilaria, De Stradis, Angelo, De Luca, Luciana, Trino, Stefania, Traficante, Antonio, D’Arena, Giovanni, Mansueto, Giovanna, Villani, Oreste, Pietrantuono, Giuseppe, Laurenti, Luca, Del Vecchio, Luigi, and Musto, Pellegrino

Published
2017
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10. High serum levels of extracellular vesicles expressing malignancy-related markers are released in patients with various types of hematological neoplastic disorders

Author

Caivano, Antonella, Laurenzana, Ilaria, De Luca, Luciana, La Rocca, Francesco, Simeon, Vittorio, Trino, Stefania, D’Auria, Fiorella, Traficante, Antonio, Maietti, Maddalena, Izzo, Tiziana, D’Arena, Giovanni, Mansueto, Giovanna, Pietrantuono, Giuseppe, Laurenti, Luca, Musto, Pellegrino, and Del Vecchio, Luigi

Published
2015
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11. Atypical Mature T-Cell Neoplasms: The Relevance of the Role of Flow Cytometry

Author

Statuto, Teodora, D’Auria, Fiorella, Del Vecchio, Luigi, Mansueto, Giovanna Rosaria, Villani, Oreste, Lalinga, Anna Vittoria, Possidente, Luciana, Nozza, Filomena, Vona, Gabriella, Rago, Luciana, Storto, Giovanni, Gasparini, Vanessa Rebecca, Zambello, Renato, D’Arena, Giovanni, and Valvano, Luciana

Subjects
angioimmunoblastic t-cell lymphoma, diagnosis, peripheral t-cell lymphoma not otherwise specified, Angioimmunoblastic T-cell lymphoma, Diagnosis, Flow cytometry, Immunophenotype, Peripheral T-cell lymphoma not otherwise specified, T-cell prolymphocytic leukemia, flow cytometry, Case Series, t-cell prolymphocytic leukemia, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282, OncoTargets and Therapy, immunophenotype
Abstract

Teodora Statuto,1,* Fiorella D’Auria,2,* Luigi Del Vecchio3,4,†, Giovanna Rosaria Mansueto,5 Oreste Villani,5 Anna Vittoria Lalinga6,†, Luciana Possidente,6 Filomena Nozza,1 Gabriella Vona,1 Luciana Rago,7 Giovanni Storto,8 Vanessa Rebecca Gasparini,9 Renato Zambello,10 Giovanni D’Arena,5,* Luciana Valvano1,* 1Laboratory of Clinical Research and Advanced Diagnostics, Centro Di Riferimento Oncologico Della Basilicata (IRCCS-CROB), Rionero in Vulture, Pz, Italy; 2Unit of Clinical Pathology, Centro Di Riferimento Oncologico Della Basilicata (IRCCS-CROB), Rionero in Vulture, Pz, Italy; 3CEINGE Biotecnologie Avanzate S.c.a.r.l, Federico II University, Naples, Italy; 4Department of Molecular Medicine and Medical Biotechnology (DMMBM), Federico II University, Naples, Italy; 5Hematology Department of Basilicata, Centro Di Riferimento Oncologico Della Basilicata (IRCCS-CROB), Rionero in Vulture, Pz, Italy; 6Pathology Unit, Centro Di Riferimento Oncologico Della Basilicata (IRCCS-CROB), Rionero in Vulture, Pz, Italy; 7Radiotherapy Unit, Centro Di Riferimento Oncologico Della Basilicata (IRCCS-CROB), Rionero in Vulture, Pz, Italy; 8Department of Nuclear Medicine, Centro Di Riferimento Oncologico Della Basilicata (IRCCS-CROB), Rionero in Vulture, Pz, Italy; 9Department of Medicine, University of Padova - Veneto Institute of Molecular Medicine, VIMM, Padova, PD, Italy; 10Hematology and Clinical Immunology, Department of Medicine, Padua School of Medicine, Padova, PD, Italy†Anna Vittoria Lalinga passed away on January 26, 2020 and Luigi Del Vecchio passed away on August 16, 2018*These authors contributed equally to this workCorrespondence: Luciana ValvanoLaboratory of Clinical Research and Advanced Diagnostics, Centro Di Riferimento Oncologico Della Basilicata (IRCCS-CROB), Rionero in Vulture, Pz, ItalyTel +39 0972 726395Fax +39 0972 723509Email luciana.valvano@crob.itAbstract: Lymphoproliferative disorders are a heterogeneous group of malignant clonal proliferations of lymphocytes whose diagnosis remains challenging, despite diagnostic criteria are now well established, due to their heterogeneity in clinical presentation and immunophenotypic profile. Lymphoid T-cell disorders are more rarely seen than B-cell entities and more difficult to diagnose for the absence of a specific immunophenotypic signature. Flow cytometry is a useful tool in diagnosing T-cell lymphoproliferative disorders since it is not only able to better characterize T-cell neoplasms but also to resolve some very complicated cases, in particular those in which a small size population of neoplastic cells is available for the analysis. Here, we report three patients with mature T-cell neoplasms with atypical clinical and biological features in which analysis of peripheral blood and bone marrow specimens by means of multicolor flow cytometry was very useful to identify and characterize three rare T-cell lymphoproliferative disorders, such as angioimmunoblastic T-cell lymphoma, peripheral T-cell lymphoma not otherwise specified and T-cell prolymphocytic leukemia. The aim of this case series report is not only to describe three rare cases of lymphoproliferative neoplasms but also to raise awareness that a fast, highly sensitive, and reproducible procedure, such as flow cytometry immunophenotyping, can have a determinant diagnostic role in these patients.Keywords: flow cytometry, immunophenotype, angioimmunoblastic T-cell lymphoma, peripheral T-cell lymphoma not otherwise specified, T-cell prolymphocytic leukemia, diagnosis

Published
2020

13. Standard dose and prolonged administration of azacitidine are associated with improved efficacy in a real-world group of patients with myelodysplastic syndrome or low blast count acute myeloid leukemia

Author

Voso, Maria Teresa, Niscola, Pasquale, Piciocchi, Alfonso, Fianchi, Luana, Maurillo, Luca, Musto, Pellegrino, Pagano, Livio, Mansueto, Giovanna, Criscuolo, Marianna, Aloe-Spiriti, Maria Antonietta, Buccisano, Francesco, Venditti, Adriano, Tendas, Andrea, Piccioni, Anna Lina, Zini, Gina, Latagliata, Roberto, Filardi, Nunzio, Fragasso, Alberto, Fenu, Susanna, and Breccia, Massimo

Published
2016
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15. Response to recombinant erythropoietin alpha, without the adjunct of granulocyte-colony stimulating factor, is associated with a longer survival in patients with transfusion-dependent myelodysplastic syndromes

Author

Musto, Pellegrino, Villani, Oreste, Martorelli, Maria Carmen, Pietrantuono, Giuseppe, Guariglia, Roberto, Mansueto, Giovanna, D’Auria, Fiorella, Grieco, Vitina, Bianchino, Gabriella, Sparano, Anna, Zonno, Antonia, Lerose, Rosa, Sanpaolo, Grazia, and Falcone, Antonietta

Published
2010
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16. Cell of origin (COO), BCL2/MYC status and IPI define a group of patients with Diffuse Large B-cell Lymphoma (DLBCL) with poor prognosis in a real-world clinical setting

Author

Bettelli, Stefania, Marcheselli, Raffaella, Pozzi, Samantha, Marcheselli, Luigi, Papotti, Robel, Forti, Elisa, Cox, M. Christina Christina, Di Napoli, Arianna, Tadmor, Tamar, Mansueto, Giovanna R., Musto, Pellegrino, Flenghi, Leonardo, Quintini, Martina, Galimberti, Sara, Lalinga, Vittoria, Donati, Valentina, Maiorana, Antonino, Polliack, Aaron, and Sacchi, Stefano

Published
2021
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17. Characteristics and outcome of therapy-related myeloid neoplasms: Report from the Italian network on secondary leukemias

Author

Fianchi, Luana, Pagano, Livio, Piciocchi, Alfonso, Candoni, Anna, Gaidano, Gianluca, Breccia, Massimo, Criscuolo, Marianna, Specchia, Giorgina, Maria Pogliani, Enrico, Maurillo, Luca, Aloe-Spiriti, Maria Antonietta, Mecucci, Cristina, Niscola, Pasquale, Rossetti, Elena, Mansueto, Giovanna, Rondoni, Michela, Fozza, Claudio, Invernizzi, Rosangela, Spadea, Antonio, Fenu, Susanna, Buda, Gabriele, Gobbi, Marco, Fabiani, Emiliano, Sica, Simona, Hohaus, Stefan, Leone, Giuseppe, and Voso, Maria Teresa

Published
2015
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18. Imatinib in Very Elderly Patients with Chronic Myeloid Leukemia in Chronic Phase: A Retrospective Study

Author

Latagliata, Roberto, Ferrero, Dario, Iurlo, Alessandra, Cavazzini, Francesco, Castagnetti, Fausto, Abruzzese, Elisabetta, Fava, Carmen, Breccia, Massimo, Annunziata, Mario, Stagno, Fabio, Tiribelli, Mario, Binotto, Gianni, Mansueto, Giovanna, Gozzini, Antonella, Russo, Sabina, Cavalli, Laura, Montefusco, Enrico, Gugliotta, Gabriele, Cedrone, Michele, Russo Rossi, Antonella, Avanzini, Paolo, Pregno, Patrizia, Mauro, Endri, Spadea, Antonio, Celesti, Francesca, Giglio, Gianfranco, Isidori, Alessandro, Crugnola, Monica, Calistri, Elisabetta, Sorà, Federica, Storti, Stefano, D’Addosio, Ada, Rege-Cambrin, Giovanna, Luciano, Luigiana, and Alimena, Giuliana

Published
2013
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19. CD200 Baseline Serum Levels Predict Prognosis of Chronic Lymphocytic Leukemia

Author

D’Arena, Giovanni, primary, Vitale, Candida, additional, Coscia, Marta, additional, Lamorte, Daniela, additional, Pietrantuono, Giuseppe, additional, Perutelli, Francesca, additional, D’Auria, Fiorella, additional, Statuto, Teodora, additional, Valvano, Luciana, additional, Tomasso, Annamaria, additional, Griggio, Valentina, additional, Jones, Rebecca, additional, Mansueto, Giovanna, additional, Villani, Oreste, additional, D’Agostino, Simona, additional, Viglioglia, Vito, additional, De Feo, Vincenzo, additional, Calapai, Fabrizio, additional, Mannucci, Carmen, additional, Sgambato, Alessandro, additional, Efremov, Dimitar G., additional, and Laurenti, Luca, additional

Published
2021
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21. Atypical Mature T-Cell Neoplasms: The Relevance of the Role of Flow Cytometry

Author

Statuto,Teodora, D'Auria,Fiorella, Del Vecchio,Luigi, Mansueto,Giovanna Rosaria, Villani,Oreste, Lalinga,Anna Vittoria, Possidente,Luciana, Nozza,Filomena, Vona,Gabriella, Rago,Luciana, Storto,Giovanni, Gasparini,Vanessa Rebecca, Zambello,Renato, D'Arena,Giovanni, Valvano,Luciana, Statuto,Teodora, D'Auria,Fiorella, Del Vecchio,Luigi, Mansueto,Giovanna Rosaria, Villani,Oreste, Lalinga,Anna Vittoria, Possidente,Luciana, Nozza,Filomena, Vona,Gabriella, Rago,Luciana, Storto,Giovanni, Gasparini,Vanessa Rebecca, Zambello,Renato, D'Arena,Giovanni, and Valvano,Luciana

Abstract

Teodora Statuto,1,* Fiorella D’Auria,2,* Luigi Del Vecchio3,4,†, Giovanna Rosaria Mansueto,5 Oreste Villani,5 Anna Vittoria Lalinga6,†, Luciana Possidente,6 Filomena Nozza,1 Gabriella Vona,1 Luciana Rago,7 Giovanni Storto,8 Vanessa Rebecca Gasparini,9 Renato Zambello,10 Giovanni D’Arena,5,* Luciana Valvano1,* 1Laboratory of Clinical Research and Advanced Diagnostics, Centro Di Riferimento Oncologico Della Basilicata (IRCCS-CROB), Rionero in Vulture, Pz, Italy; 2Unit of Clinical Pathology, Centro Di Riferimento Oncologico Della Basilicata (IRCCS-CROB), Rionero in Vulture, Pz, Italy; 3CEINGE Biotecnologie Avanzate S.c.a.r.l, Federico II University, Naples, Italy; 4Department of Molecular Medicine and Medical Biotechnology (DMMBM), Federico II University, Naples, Italy; 5Hematology Department of Basilicata, Centro Di Riferimento Oncologico Della Basilicata (IRCCS-CROB), Rionero in Vulture, Pz, Italy; 6Pathology Unit, Centro Di Riferimento Oncologico Della Basilicata (IRCCS-CROB), Rionero in Vulture, Pz, Italy; 7Radiotherapy Unit, Centro Di Riferimento Oncologico Della Basilicata (IRCCS-CROB), Rionero in Vulture, Pz, Italy; 8Department of Nuclear Medicine, Centro Di Riferimento Oncologico Della Basilicata (IRCCS-CROB), Rionero in Vulture, Pz, Italy; 9Department of Medicine, University of Padova - Veneto Institute of Molecular Medicine, VIMM, Padova, PD, Italy; 10Hematology and Clinical Immunology, Department of Medicine, Padua School of Medicine, Padova, PD, Italy†Anna Vittoria Lalinga passed away on January 26, 2020 and Luigi Del Vecchio passed away on August 16, 2018*These authors contributed equally to this workCorrespondence: Luciana ValvanoLaboratory of Clinical Research and Advanced Diagnostics, Centro Di Riferimento Oncologico Della Basilicata (IRCCS-CROB), Rionero in Vulture, Pz, ItalyTel +39 0972 726395Fax +39 0972 723509Email luciana.valvano@crob.itAbstract: Lymphoproliferative disorders are a heterogeneous

Published
2020

22. CIRCULATING REGULATORY T-CELL NUMBER DOES NOT PREDICT PROGNOSIS OF MONOCLONAL GAMMOPATHIES OF UNCERTAIN SIGNIFICANCE

Author

Statuto, Teodora, primary, VALVANO, LUCIANA, additional, Calice, Giovanni, additional, Pietrantuono, Giuseppe, additional, Mansueto, Giovanna, additional, Villani, Oreste, additional, Marano, Luana, additional, D'Agostino, Simona, additional, D'Auria, Fiorella, additional, Traficante, Antonio, additional, Sgambato, Alessandro, additional, and D'Arena, Giovanni, additional

Published
2021
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23. A shorter time to the first treatment may be predicted by the absolute number of regulatory T-cells in patients with Rai stage 0 chronic lymphocytic leukemia

Author

DʼArena, Giovanni, DʼAuria, Fiorella, Simeon, Vittorio, Laurenti, Luca, Deaglio, Silvia, Mansueto, Giovanna, Principe, Maria Ilaria Del, Statuto, Teodora, Pietrantuono, Giuseppe, Guariglia, Roberto, Innocenti, Idanna, Martorelli, Maria Carmen, Villani, Oreste, De Feo, Vincenzo, Poeta, Giovanni Del, and Musto, Pellegrino

Published
2012
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24. CD200 and Chronic Lymphocytic Leukemia: Biological and Clinical Relevance

Author

D’Arena, Giovanni, primary, De Feo, Vincenzo, additional, Pietrantuono, Giuseppe, additional, Seneca, Elisa, additional, Mansueto, Giovanna, additional, Villani, Oreste, additional, La Rocca, Francesco, additional, D’Auria, Fiorella, additional, Statuto, Teodora, additional, Valvano, Luciana, additional, Arruga, Francesca, additional, Deaglio, Silvia, additional, Efremov, Dimitar G., additional, Sgambato, Alessandro, additional, and Laurenti, Luca, additional

Published
2020
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26. MYC Rearranged Aggressive B-Cell Lymphomas

Author

Tisi, Maria Chiara, Ferrero, Simone, Dogliotti, Irene, Tecchio, Cristina, Carli, Giuseppe, Novo, Mattia, Stefani, Piero Maria, Rattotti, Sara, Balzarotti, Monica, Marino, Dario, Pelosini, Matteo, Romano, Alessandra, Flenghi, Leonardo, Zilioli, Vittorio Ruggero, Calimeri, Teresa, Di Napoli, Arianna, Zanni, Manuela, Finolezzi, Erica, Mosna, Federico, Gini, Guido, Mansueto, Giovanna, Di Rocco, Alice, Tomei, Gabriella, Sgherza, Nicola, Olivieri, Jacopo, Nassi, Luca, Piazza, Francesco, Fama, Angelo, Greco, Antonio, Giannoccaro, Margherita, Mazzone, Anna Maria, Visco, Carlo, Loseto, Giacomo, and Zaja, Francesco

Subjects
aggressive B lymphoma, C-myc rearrangement, C-myc rearrangement, aggressive B lymphoma
Published
2019

27. Clinical Relevance of Individual Response to Iron Chelation Therapy (ICT) in Patients with Myelodysplastic Syndromes (MDS) and Transfusion Requirement

Author

Latagliata, Roberto, primary, Niscola, Pasquale, additional, Oliva, Esther Natalie, additional, Riva, Marta, additional, Capodanno, Isabella, additional, Volpe, Antonio, additional, Pilo, Federica, additional, Baratè, Claudia, additional, Campagna, Alessia, additional, Pelizzari, Anna Maria, additional, Poloni, Antonella, additional, Sarlo, Chiara, additional, Mansueto, Giovanna, additional, Piccioni, Anna Lina, additional, Rosati, Serena, additional, Carmosino, Ida, additional, Carbone, Antonella, additional, Tognazzi, Lucia, additional, Salutari, Prassede, additional, Mancini, Annalisa, additional, Cuffari, Patrizia, additional, Pennese, Elsa, additional, Fenu, Susanna, additional, Aloe Spiriti, Maria Antonietta, additional, Galimberti, Sara, additional, Molteni, Alfredo, additional, Balleari, Enrico, additional, Breccia, Massimo, additional, Foà, Robin, additional, Maurillo, Luca, additional, and Finelli, Carlo, additional

Published
2019
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28. MYC Rearranged Aggressive B-Cell Lymphomas: A Report on 100 Patients of the Fondazione Italiana Linfomi (FIL)

Author

Tisi, Maria Chiara, primary, Ferrero, Simone, additional, Dogliotti, Irene, additional, Tecchio, Cristina, additional, Carli, Giuseppe, additional, Novo, Mattia, additional, Stefani, Piero Maria, additional, Rattotti, Sara, additional, Balzarotti, Monica, additional, Marino, Dario, additional, Pelosini, Matteo, additional, Romano, Alessandra, additional, Flenghi, Leonardo, additional, Zilioli, Vittorio Ruggero, additional, Calimeri, Teresa, additional, Di Napoli, Arianna, additional, Zanni, Manuela, additional, Finolezzi, Erica, additional, Mosna, Federico, additional, Gini, Guido, additional, Mansueto, Giovanna, additional, Di Rocco, Alice, additional, Tomei, Gabriella, additional, Sgherza, Nicola, additional, Olivieri, Jacopo, additional, Nassi, Luca, additional, Piazza, Francesco, additional, Fama, Angelo, additional, Greco, Antonio, additional, Giannoccaro, Margherita, additional, Mazzone, Anna Maria, additional, Visco, Carlo, additional, Loseto, Giacomo, additional, and Zaja, Francesco, additional

Published
2019
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29. CD200 and Chronic Lymphocytic Leukemia: Biological and Clinical Relevance.

Author

D'Arena, Giovanni, De Feo, Vincenzo, Pietrantuono, Giuseppe, Seneca, Elisa, Mansueto, Giovanna, Villani, Oreste, La Rocca, Francesco, D'Auria, Fiorella, Statuto, Teodora, Valvano, Luciana, Arruga, Francesca, Deaglio, Silvia, Efremov, Dimitar G., Sgambato, Alessandro, and Laurenti, Luca

Subjects
CHRONIC lymphocytic leukemia, T cells, B cells, MANTLE cell lymphoma, IMMUNOREGULATION, CHRONIC leukemia
Abstract

CD200, a transmembrane type Ia glycoprotein belonging to the immunoglobulin protein superfamily, is broadly expressed on a wide variety of cell types, such as B lymphocytes, a subset of T lymphocytes, dendritic cells, endothelial and neuronal cells. It delivers immunosuppressive signals through its receptor CD200R, which is expressed on monocytes/myeloid cells and T lymphocytes. Moreover, interaction of CD200 with CD200R has also been reported to play a role in the regulation of tumor immunity. Overexpression of CD200 has been reported in chronic lymphocytic leukemia (CLL) and hairy cell leukemia but not in mantle cell lymphoma, thus helping to better discriminate between these different B cell malignancies with different prognosis. In this review, we focus on the role of CD200 expression in the differential diagnosis of mature B-cell neoplasms and on the prognostic significance of CD200 expression in CLL, where conflicting results have been published so far. Of interest, increasing evidences indicate that anti-CD200 treatment might be therapeutically beneficial for treating CD200-expressing malignancies, such as CLL. [ABSTRACT FROM AUTHOR]

Published
2020
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31. Is re-challenge still an option as salvage therapy in multiple myeloma? The case of REal-life BOrtezomib re-Use as secoND treatment for relapsed patients exposed frontline to bortezomib-based therapies (the REBOUND Study)

Author

Musto, Pellegrino, primary, Simeon, Vittorio, additional, Cascavilla, Nicola, additional, Falcone, Antonietta, additional, Petrucci, Maria Teresa, additional, Cesini, Laura, additional, Di Raimondo, Francesco, additional, Conticello, Concetta, additional, Ria, Roberto, additional, Catalano, Lucio, additional, Salvatore, Dalila, additional, Mastrullo, Lucia, additional, Gagliardi, Alfredo, additional, Villani, Oreste, additional, Pietrantuono, Giuseppe, additional, D’Arena, Giovanni, additional, Mansueto, Giovanna, additional, Bringhen, Sara, additional, Genuardi, Mariella, additional, Di Renzo, Nicola, additional, Reddiconto, Giovanni, additional, Fragasso, Alberto, additional, Caravita, Tommaso, additional, Scapicchio, Daniele, additional, Marziano, Gioacchino, additional, Boccadoro, Mario, additional, Mangiacavalli, Silvia, additional, and Corso, Alessandro, additional

Published
2018
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33. Iron-chelating therapy with deferasirox in transfusion-dependent, higher risk myelodysplastic syndromes: a retrospective, multicentre study

Author

Musto, Pellegrino, primary, Maurillo, Luca, additional, Simeon, Vittorio, additional, Poloni, Antonella, additional, Finelli, Carlo, additional, Balleari, Enrico, additional, Ricco, Alessandra, additional, Rivellini, Flavia, additional, Cortelezzi, Agostino, additional, Tarantini, Giuseppe, additional, Villani, Oreste, additional, Mansueto, Giovanna, additional, Milella, Maria R., additional, Scapicchio, Daniele, additional, Marziano, Gioacchino, additional, Breccia, Massimo, additional, Niscola, Pasquale, additional, Sanna, Alessandro, additional, Clissa, Cristina, additional, Voso, Maria T., additional, Fenu, Susanna, additional, Venditti, Adriano, additional, Santini, Valeria, additional, Angelucci, Emanuele, additional, and Levis, Alessandro, additional

Published
2017
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34. Real Life, Retrospective Analysis of Bortezomib Re-Use As Second Treatment for Relapsed Multiple Myeloma Patients Previously Exposed to Bortezomib-Based Therapies As First Line: The Rebound Study

Author

Musto, Pellegrino, primary, Simeon, Vittorio, additional, Cascavilla, Nicola, additional, Falcone, Antonietta, additional, Petrucci, Maria Teresa, additional, Cesini, Laura, additional, Di Raimondo, Francesco, additional, Conticello, Concetta, additional, Ria, Roberto, additional, Catalano, Lucio, additional, Salvatore, Dalila, additional, Mastrullo, Lucia, additional, Gagliardi, Alfredo, additional, Villani, Oreste, additional, Pietrantuono, Giuseppe, additional, D'Arena, Giovanni, additional, Mansueto, Giovanna, additional, Patriarca, Andrea, additional, Bringhen, Sara, additional, Genuardi, Mariella, additional, Di Renzo, Nicola, additional, Reddiconto, Giovanni, additional, Fragasso, Alberto, additional, Caravita, Tommaso, additional, Mangiacavalli, Silvia, additional, Palumbo, Antonio, additional, and Corso, Alessandro, additional

Published
2016
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35. Characterization and Prognostic Relevance of Circulating Microvesicles in Chronic Lymphocytic Leukemia

Author

De Luca, Luciana, primary, D'Arena, Giovanni, additional, Simeon, Vittorio, additional, Trino, Stefania, additional, Laurenzana, Ilaria, additional, Caivano, Antonella, additional, La Rocca, Francesco, additional, Villani, Oreste, additional, Mansueto, Giovanna, additional, Deaglio, Silvia, additional, Innocenti, Idanna, additional, Laurenti, Luca, additional, Molica, Stefano, additional, Pietrantuono, Giuseppe, additional, De Stradis, Angelo, additional, Del Vecchio, Luigi, additional, and Musto, Pellegrino, additional

Published
2016
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36. Characterization and prognostic relevance of circulating microvesicles in chronic lymphocytic leukemia

Author

De Luca, Luciana, D’Arena, Giovanni, Simeon, Vittorio, Trino, Stefania, Laurenzana, Ilaria, Caivano, Antonella, La Rocca, Francesco, Villani, Oreste, Mansueto, Giovanna Rosaria, Deaglio, Silvia, Innocenti, Idanna, Laurenti, Luca, Molica, Stefano, Pietrantuono, Giuseppe, De Stradis, Angelo, Del Vecchio, Luigi, Musto, Pellegrino, Laurenti, Luca (ORCID:0000-0002-8327-1396), De Luca, Luciana, D’Arena, Giovanni, Simeon, Vittorio, Trino, Stefania, Laurenzana, Ilaria, Caivano, Antonella, La Rocca, Francesco, Villani, Oreste, Mansueto, Giovanna Rosaria, Deaglio, Silvia, Innocenti, Idanna, Laurenti, Luca, Molica, Stefano, Pietrantuono, Giuseppe, De Stradis, Angelo, Del Vecchio, Luigi, Musto, Pellegrino, and Laurenti, Luca (ORCID:0000-0002-8327-1396)

Abstract

Microvescicles (MV) are shedding particles released by normal and neoplastic cells, whose levels in biological fluids highlight their potential role as disease biomarkers and therapeutic targets. By analyzing 131 newly diagnosed chronic lymphocytic leukemia (CLL), we found that the absolute number of serum CLL MV was significantly higher than in controls, in particular in advanced stages of disease. In addition, CD19 + and CD37+, B-cell derived MV, significantly correlated with high tumor burden. Absolute MV number cutoff selected by ROC analysis distinguished Rai stage 0 patients with shorter time to treatment (TTT) from those with more stable disease. Likewise, in the entire cohort, two groups of patients with different overall survival (OS) and different TTT were identified. At multivariate analysis, serum MV independently predicted for OS (along with Rai stage) and TTT (along with Rai stage, lymphocytes and CD38). In conclusion, circulating MV represent a new potential prognostic biomarker in CLL.

Published
2016

37. Imatinib and polypharmacy in very old patients with chronic myeloid leukemia: Effects on response rate, toxicity and outcome

Author

Iurlo, Alessandra, Nobili, Alessandro, Latagliata, Roberto, Bucelli, Cristina, Castagnetti, Fausto, Breccia, Massimo, Abruzzese, Elisabetta, Cattaneo, Daniele, Fava, Carmen, Ferrero, Dario, Gozzini, Antonella, Bonifacio, Massimiliano, Tiribelli, Mario, Pregno, Patrizia, Stagno, Fabio, Vigneri, Paolo, Annunziata, Mario, Cavazzini, Francesco, Binotto, Gianni, Mansueto, Giovanna Rosaria, Russo, Sabina, Falzetti, Franca, Montefusco, Enrico, Gugliotta, Gabriele, Storti, Sergio, D'Addosio, Ada M., Scaffidi, Luigi, Cortesi, Laura, Cedrone, Michele, Rossi, Antonella Russo, Avanzini, Paolo, Mauro, Endri, Spadea, Antonio, Celesti, Francesca, Giglio, Gianfranco, Isidori, Alessandro, Crugnola, Monica, Calistri, Elisabetta, Sora', Federica, Rege Cambrin, Giovanna, Sica, Simona, Luciano, Luigiana, Galimberti, Sara, Orlandi, Ester M., Bocchia, Monica, Tettamanti, Mauro, Alimena, Giuliana, Saglio, Giuseppe, Rosti, Gianantonio, Mannucci, Pier Mannuccio, Cortelezzi, Agostino, Storti, Sergio (ORCID:0000-0002-4374-3985), Sora', Federica (ORCID:0000-0002-9607-5298), Sica, Simona (ORCID:0000-0003-2426-3465), Iurlo, Alessandra, Nobili, Alessandro, Latagliata, Roberto, Bucelli, Cristina, Castagnetti, Fausto, Breccia, Massimo, Abruzzese, Elisabetta, Cattaneo, Daniele, Fava, Carmen, Ferrero, Dario, Gozzini, Antonella, Bonifacio, Massimiliano, Tiribelli, Mario, Pregno, Patrizia, Stagno, Fabio, Vigneri, Paolo, Annunziata, Mario, Cavazzini, Francesco, Binotto, Gianni, Mansueto, Giovanna Rosaria, Russo, Sabina, Falzetti, Franca, Montefusco, Enrico, Gugliotta, Gabriele, Storti, Sergio, D'Addosio, Ada M., Scaffidi, Luigi, Cortesi, Laura, Cedrone, Michele, Rossi, Antonella Russo, Avanzini, Paolo, Mauro, Endri, Spadea, Antonio, Celesti, Francesca, Giglio, Gianfranco, Isidori, Alessandro, Crugnola, Monica, Calistri, Elisabetta, Sora', Federica, Rege Cambrin, Giovanna, Sica, Simona, Luciano, Luigiana, Galimberti, Sara, Orlandi, Ester M., Bocchia, Monica, Tettamanti, Mauro, Alimena, Giuliana, Saglio, Giuseppe, Rosti, Gianantonio, Mannucci, Pier Mannuccio, Cortelezzi, Agostino, Storti, Sergio (ORCID:0000-0002-4374-3985), Sora', Federica (ORCID:0000-0002-9607-5298), and Sica, Simona (ORCID:0000-0003-2426-3465)

Abstract

Background: About 40% of all patients with chronic myeloid leukemia are currently old or very old. They are effectively treated with imatinib, even though underrepresented in clinical studies. Furthermore, as it happens in the general population, they often receive multiple drugs for associated chronic illnesses. Aim of this study was to assess whether or not in imatinib-treated patients aged > 75 years the exposure to polypharmacy (5 drugs or more) had an impact on cytogenetic and molecular response rates, event-free and overall survival, as well as on hematological or extra-hematological toxicity. Methods: 296 patients at 35 Italian hematological institutions were evaluated. Results: Polypharmacy was reported in 107 patients (36.1%), and drugs more frequently used were antiplatelets, diuretics, proton pump inhibitors, ACE-inhibitors, beta-blockers, calcium channel blockers, angiotensin II receptors blockers, statins, oral hypoglycemic drugs and alpha blockers. Complete cytogenetic response was obtained in 174 patients (58.8%), 78 (26.4%) within 6 month, 63 (21.3%) between 7 and 12 months. Major molecular response was obtained in 153 patients (51.7%), 64 (21.6%) within the 12 month. One hundred and twenty-eight cases (43.2%) of hematological toxicity were recorded, together with 167 cases (56.4%) of extra-hematological toxicity. Comparing patients exposed to polypharmacy to those without, no difference was observed pertaining to the dosage of imatinib, cytogenetic and molecular responses and hematological and extra-hematological toxicity. Conclusion: Notwithstanding the several interactions reported in the literature between imatinib and some of the medications considered herewith, this fact does not seem to have a clinical impact on response rate and outcome.

Published
2016

38. MicroRNA-155 in serum-derived extracellular vesicles as a potential biomarker for hematologic malignancies - a short report

Author

Caivano, Antonella, La Rocca, Francesco, Simeon, Vittorio, Girasole, Marco, Dinarelli, Simone, Laurenzana, Ilaria, De Stradis, Angelo, De Luca, Luciana, Trino, Stefania, Traficante, Antonio, D'Arena, Giovanni, Mansueto, Giovanna Rosaria, Villani, Oreste, Pietrantuono, Giuseppe, Laurenti, Luca, Del Vecchio, Luigi, Musto, Pellegrino, Laurenti, Luca (ORCID:0000-0002-8327-1396), Caivano, Antonella, La Rocca, Francesco, Simeon, Vittorio, Girasole, Marco, Dinarelli, Simone, Laurenzana, Ilaria, De Stradis, Angelo, De Luca, Luciana, Trino, Stefania, Traficante, Antonio, D'Arena, Giovanni, Mansueto, Giovanna Rosaria, Villani, Oreste, Pietrantuono, Giuseppe, Laurenti, Luca, Del Vecchio, Luigi, Musto, Pellegrino, and Laurenti, Luca (ORCID:0000-0002-8327-1396)

Abstract

The use of extracellular vesicles (EVs) from body fluids as "liquid biopsies" is emerging as a promising approach for the diagnosis, prognosis and therapeutic monitoring of cancer patients. MicroRNA-155 (miR155), a non-coding transcript of the B-cell integration cluster (BIC) gene, has been reported to play a critical role in the pathogenesis of several types of hematologic malignancies (HMs) in which high miR155 levels have been found. At yet, however, the EV miR155 level and its putative clinical relevance in sera of HM patients have not been reported. METHODS: EVs from sera of representative patients with eight different HMs and healthy subjects (controls) were isolated using differential centrifugation. The identity and quality of the EVs were verified by atomic force and transmission electron microscopy. The EV miR155 levels were measured by quantitative RT-PCR. The sensitivity, specificity and area under the curve (AUC) of differences in EV miR155 levels were determined using ROC curve analyses. RESULTS: We found that the EV miR155 levels were significantly higher in chronic lymphocytic leukemia (CLL), acute myeloid leukemia (AML) and Waldenström's macroglobulinemia (WM) cases compared to controls. Conversely, we found that the EV miR155 levels were significantly lower in myelodysplastic syndrome (MDS) and multiple myeloma (MM) cases. No differences were found in follicular lymphoma (FL), diffuse large B-cell lymphoma (DLBCL) or Hodgkin's Lymphoma (HL) cases compared to controls. EV miR155 ROC curve analyses revealed significantly different patterns in CLL and AML cases compared to controls, and in AML cases compared to MDS cases (p = 0.004, p = 0.01 and p = 0.04, respectively). In addition, we found that high EV miR155 levels correlated with high white blood cell counts in AML patients. CONCLUSION: Our data indicate that EV miR155 may serve as an attractive new, non-invasive diagnostic biomarker in human hematologic malignancies.

Published
2016

39. MicroRNA-155 in serum-derived extracellular vesicles as a potential biomarker for hematologic malignancies - a short report

Author

Caivano, Antonella, primary, La Rocca, Francesco, additional, Simeon, Vittorio, additional, Girasole, Marco, additional, Dinarelli, Simone, additional, Laurenzana, Ilaria, additional, De Stradis, Angelo, additional, De Luca, Luciana, additional, Trino, Stefania, additional, Traficante, Antonio, additional, D’Arena, Giovanni, additional, Mansueto, Giovanna, additional, Villani, Oreste, additional, Pietrantuono, Giuseppe, additional, Laurenti, Luca, additional, Del Vecchio, Luigi, additional, and Musto, Pellegrino, additional

Published
2016
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40. Imatinib and polypharmacy in very old patients with chronic myeloid leukemia: effects on response rate, toxicity and outcome

Author

Iurlo, Alessandra, primary, Nobili, Alessandro, additional, Latagliata, Roberto, additional, Bucelli, Cristina, additional, Castagnetti, Fausto, additional, Breccia, Massimo, additional, Abruzzese, Elisabetta, additional, Cattaneo, Daniele, additional, Fava, Carmen, additional, Ferrero, Dario, additional, Gozzini, Antonella, additional, Bonifacio, Massimiliano, additional, Tiribelli, Mario, additional, Pregno, Patrizia, additional, Stagno, Fabio, additional, Vigneri, Paolo, additional, Annunziata, Mario, additional, Cavazzini, Francesco, additional, Binotto, Gianni, additional, Mansueto, Giovanna, additional, Russo, Sabina, additional, Falzetti, Franca, additional, Montefusco, Enrico, additional, Gugliotta, Gabriele, additional, Storti, Sergio, additional, D’Addosio, Ada M., additional, Scaffidi, Luigi, additional, Cortesi, Laura, additional, Cedrone, Michele, additional, Rossi, Antonella Russo, additional, Avanzini, Paolo, additional, Mauro, Endri, additional, Spadea, Antonio, additional, Celesti, Francesca, additional, Giglio, Gianfranco, additional, Isidori, Alessandro, additional, Crugnola, Monica, additional, Calistri, Elisabetta, additional, Sorà, Federica, additional, Rege-Cambrin, Giovanna, additional, Sica, Simona, additional, Luciano, Luigiana, additional, Galimberti, Sara, additional, Orlandi, Ester M., additional, Bocchia, Monica, additional, Tettamanti, Mauro, additional, Alimena, Giuliana, additional, Saglio, Giuseppe, additional, Rosti, Gianantonio, additional, Mannuccio Mannucci, Pier, additional, and Cortelezzi, Agostino, additional

Published
2016
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41. Standard dose and prolonged administration of azacitidine are associated with improved efficacy in a real-world group of patients with myelodysplastic syndrome or low blast count acute myeloid leukemia

Author

Voso, MT, Niscola, P, Piciocchi, A, FIANCHI, LUANA, Maurillo, L, Musto, P, PAGANO, LIVIO, MANSUETO, GIOVANNA ROSARIA, CRISCUOLO, MARIANNA, Aloe-Spiriti, MA, Buccisano, F, Venditti, A, Tendas, A, Piccioni, AL, ZINI, GINA, Latagliata, R, FILARDI, ANTONIA NATALINA, Fragasso, A, Fenu, S, BRECCIA, MARCO, Voso, MT, Niscola, P, Piciocchi, A, FIANCHI, LUANA, Maurillo, L, Musto, P, PAGANO, LIVIO, MANSUETO, GIOVANNA ROSARIA, CRISCUOLO, MARIANNA, Aloe-Spiriti, MA, Buccisano, F, Venditti, A, Tendas, A, Piccioni, AL, ZINI, GINA, Latagliata, R, FILARDI, ANTONIA NATALINA, Fragasso, A, Fenu, S, and BRECCIA, MARCO

Published
2015

42. Long-Term Follow-up in Very Elderly Patients with Chronic Myeloid Leukemia Treated with Imatinib Frontline

Author

Latagliata, Roberto, primary, Breccia, Massimo, additional, Ferrero, Dario, additional, Cavazzini, Francesco, additional, Trawinska, Malgorzata Monika, additional, Castagnetti, Fausto, additional, Annunziata, Mario, additional, Stagno, Fabio, additional, Tiribelli, Mario, additional, Binotto, Gianni, additional, Fava, Carmen, additional, Crisà, Elena, additional, Mansueto, Giovanna, additional, Gozzini, Antonella, additional, Falzetti, Franca, additional, Montefusco, Enrico, additional, Iurlo, Alessandra, additional, Sabina, Russo, additional, Cedrone, Michele, additional, Russo Rossi, Antonella, additional, Gugliotta, Gabriele, additional, Pregno, Patrizia, additional, Isidori, Alessandro, additional, Avanzini, Paolo, additional, Endri, Mauro, additional, Romano, Atelda, additional, Giglio, Gianfranco, additional, Celesti, Francesca, additional, Sorà, Federica, additional, Storti, Sergio, additional, D'Addosio, Ada, additional, Galimberti, Sara, additional, Orlandi, Ester Maria, additional, Calistri, Elisabetta, additional, Bocchia, Monica, additional, Crugnola, Monica, additional, Rege Cambrin, Giovanna, additional, Vigneri, Paolo, additional, Luciano, Luigiana, additional, Abruzzese, Elisabetta, additional, and Alimena, Giuliana, additional

Published
2015
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43. Very Elderly Patients with Chronic Phase-Chronic Myeloid Leukemia on Imatinib: No Impact of Concomitant Drugs on Complete Cytogenetic Response

Author

Iurlo, Alessandra, primary, Latagliata, Roberto, additional, Bucelli, Cristina, additional, Ferrero, Dario, additional, Castagnetti, Fausto, additional, Breccia, Massimo, additional, Abruzzese, Elisabetta, additional, Cattaneo, Daniele, additional, Fava, Carmen, additional, Gozzini, Antonella, additional, Annunziata, Mario, additional, Tiribelli, Mario, additional, Pregno, Patrizia, additional, Stagno, Fabio, additional, Vigneri, Paolo, additional, Cavazzini, Francesco, additional, Binotto, Gianni, additional, Mansueto, Giovanna, additional, Russo, Sabina, additional, Falzetti, Franca, additional, Montefusco, Enrico, additional, Gugliotta, Gabriele, additional, Gasbarrino, Cristiana, additional, D'Addosio, Ada, additional, Cortesi, Laura, additional, Cedrone, Michele, additional, Russo Rossi, Antonella, additional, Avanzini, Paolo, additional, Endri, Mauro, additional, Spadea, Antonio, additional, Celesti, Francesca, additional, Giglio, Gianfranco, additional, Isidori, Alessandro, additional, Crugnola, Monica, additional, Calistri, Elisabetta, additional, Sorà, Federica, additional, Rege-Cambrin, Giovanna, additional, Sica, Simona, additional, Luciano, Luigia, additional, Orlandi, Ester Maria, additional, Bocchia, Monica, additional, Tettamanti, Mauro, additional, Alimena, Giuliana, additional, Saglio, Giuseppe, additional, Rosti, Gianantonio, additional, Nobili, Alessandro, additional, Mannucci, Pier Mannuccio, additional, and Cortelezzi, Agostino, additional

Published
2015
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44. Bendamustine in relapsed/refractory multiple myeloma: the “real-life” side of the moon

Author

Musto, Pellegrino, primary, Fraticelli, Vincenzo Ludovico, additional, Mansueto, Giovanna, additional, Madonna, Emanuela, additional, Nozza, Andrea, additional, Andriani, Alessandro, additional, Mussetti, Alberto, additional, Ballanti, Stelvio, additional, Bongarzoni, Velia, additional, Baraldi, Anna, additional, Patriarca, Francesca, additional, Vincelli, Donatella, additional, Falcone, Antonietta, additional, Derudas, Daniele, additional, Califano, Catello, additional, Zambello, Renato, additional, Mele, Giuseppe, additional, Fragasso, Alberto, additional, Baldini, Luca, additional, and Storti, Sergio, additional

Published
2015
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45. Incidence of Infectious Complications in MDS/AML Patients Treated with Azacitidine By the Italian Cooperative Groups Gruppo Romano MDS (GROM) and Basilicata MDS Registry

Author

Voso, Maria Teresa, primary, Niscola, Pasquale, additional, Piciocchi, Alfonso, additional, Pagano, Livio, additional, Maurillo, Luca, additional, Musto, Pellegrino, additional, Fianchi, Luana, additional, Mansueto, Giovanna, additional, Aloe-Spiriti, Antonietta, additional, Buccisano, Francesco, additional, Venditti, Adriano, additional, Tendas, Andrea, additional, Mancini, Stefano, additional, Piccioni, Anna Lina, additional, Andriani, Alessandro, additional, Latagliata, Roberto, additional, Alimena, Giuliana, additional, Filardi, Nunzio, additional, Fragasso, Alberto, additional, Tafuri, Agostino, additional, Fenu, Susanna, additional, and Breccia, Massimo, additional

Published
2014
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46. Characterization and prognostic relevance of circulating microvesicles in chronic lymphocytic leukemia.

Author

De Luca, Luciana, D'Arena, Giovanni, Simeon, Vittorio, Trino, Stefania, Laurenzana, Ilaria, Caivano, Antonella, La Rocca, Francesco, Villani, Oreste, Mansueto, Giovanna, Deaglio, Silvia, Innocenti, Idanna, Laurenti, Luca, Molica, Stefano, Pietrantuono, Giuseppe, De Stradis, Angelo, Del Vecchio, Luigi, and Musto, Pellegrino

Subjects
LYMPHOCYTIC leukemia, MULTIVARIATE analysis, B cells, SERUM, LYMPHOCYTES, TUMORS, DIAGNOSIS
Abstract

Microvescicles (MV) are shedding particles released by normal and neoplastic cells, whose levels in biological fluids highlight their potential role as disease biomarkers and therapeutic targets. By analyzing 131 newly diagnosed chronic lymphocytic leukemia (CLL), we found that the absolute number of serum CLL MV was significantly higher than in controls, in particular in advanced stages of disease. In addition, CD19 + and CD37+, B-cell derived MV, significantly correlated with high tumor burden. Absolute MV number cutoff selected by ROC analysis distinguished Rai stage 0 patients with shorter time to treatment (TTT) from those with more stable disease. Likewise, in the entire cohort, two groups of patients with different overall survival (OS) and different TTT were identified. At multivariate analysis, serum MV independently predicted for OS (along with Rai stage) and TTT (along with Rai stage, lymphocytes and CD38). In conclusion, circulating MV represent a new potential prognostic biomarker in CLL. [ABSTRACT FROM PUBLISHER]

Published
2017
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47. More on spontaneous regression of chronic lymphocytic leukemia: two new cases and potential role of lamivudine in a further patient with advanced disease and hepatitis B virus infection

Author

D’Arena, Giovanni, primary, Guariglia, Roberto, additional, Pietrantuono, Giuseppe, additional, Villani, Oreste, additional, Martorelli, Maria Carmen, additional, Mansueto, Giovanna, additional, Criscuolo, Clelia, additional, Pierri, Teresa, additional, Musto, Clelia, additional, and Musto, Pellegrino, additional

Published
2014
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48. Frontline chemotherapy with bortezomib-containing combinations improves response rate and survival in primary plasma cell leukemia: a retrospective study from GIMEMA Multiple Myeloma Working Party

Author

D'Arena, G, Valentini, Cg, Pietrantuono, G, Guariglia, R, Martorelli, Mc, Mansueto, Giovanna Rosaria, Villani, O, Onofrillo, D, Falcone, A, Specchia, G, Semenzato, G, Di Renzo, N, Mastrullo, L, Venditti, Antonella, Ferrara, Ferdinando, Palumbo, A, Pagano, Livio, Musto, P., Pagano, Livio (ORCID:0000-0001-8287-928X), D'Arena, G, Valentini, Cg, Pietrantuono, G, Guariglia, R, Martorelli, Mc, Mansueto, Giovanna Rosaria, Villani, O, Onofrillo, D, Falcone, A, Specchia, G, Semenzato, G, Di Renzo, N, Mastrullo, L, Venditti, Antonella, Ferrara, Ferdinando, Palumbo, A, Pagano, Livio, Musto, P., and Pagano, Livio (ORCID:0000-0001-8287-928X)

Abstract

The best therapeutic approach for primary plasma cell leukemia (PPCL) remains unknown so far. In very limited studies, the poor clinical outcome of this aggressive variant of multiple myeloma seemed to be ameliorated by the use of the proteasome inhibitor bortezomib. Aiming to provide more consolidated data, this multicenter retrospective survey focused on unselected and previously untreated PPCL patients who had received bortezomib as frontline therapy.

Published
2012

49. Cell-free circulating DNA in Hodgkin's and non-Hodgkin's lymphomas

Author

Hohaus, Stefan, Giachelia, Manuela, Massini, Giuseppina, Mansueto, Giovanna Rosaria, Vannata, Barbara, Bozzoli, Valentina, Criscuolo, Marianna, D'Alo', Francesco, Martini, Maurizio, Larocca, Luigi Maria, Voso, Maria Teresa, Leone, Giuseppe, Hohaus, Stefan (ORCID:0000-0002-5534-7197), D'Alo', Francesco (ORCID:0000-0003-3576-8522), Martini, Maurizio (ORCID:0000-0002-6260-6310), Larocca, Luigi Maria (ORCID:0000-0003-1739-4758), Hohaus, Stefan, Giachelia, Manuela, Massini, Giuseppina, Mansueto, Giovanna Rosaria, Vannata, Barbara, Bozzoli, Valentina, Criscuolo, Marianna, D'Alo', Francesco, Martini, Maurizio, Larocca, Luigi Maria, Voso, Maria Teresa, Leone, Giuseppe, Hohaus, Stefan (ORCID:0000-0002-5534-7197), D'Alo', Francesco (ORCID:0000-0003-3576-8522), Martini, Maurizio (ORCID:0000-0002-6260-6310), and Larocca, Luigi Maria (ORCID:0000-0003-1739-4758)

Abstract

Levels of cell-free circulating DNA have been correlated to clinical characteristics and prognosis in patients with cancers of epithelial origin, while there are no data on patients with B-lymphoproliferative diseases.

Published
2009

50. Intravascular large-B cell lymphoma: when lymphoma is suspected but routine diagnostic work-up is negative.

Author

Bozzoli, Valentina, Tisi, Maria Chiara, D'Alo', Francesco, Massini, Giuseppina, Mansueto, Giovanna Rosaria, Vannata, Barbara, Arena, Vincenzo, Larocca, Luigi Maria, Teofili, Luciana, Leone, Giuseppe, Hohaus, Stefan, D'Alo', Francesco (ORCID:0000-0003-3576-8522), Arena, Vincenzo (ORCID:0000-0002-7562-223X), Larocca, Luigi Maria (ORCID:0000-0003-1739-4758), Teofili, Luciana (ORCID:0000-0002-7214-1561), Hohaus, Stefan (ORCID:0000-0002-5534-7197), Bozzoli, Valentina, Tisi, Maria Chiara, D'Alo', Francesco, Massini, Giuseppina, Mansueto, Giovanna Rosaria, Vannata, Barbara, Arena, Vincenzo, Larocca, Luigi Maria, Teofili, Luciana, Leone, Giuseppe, Hohaus, Stefan, D'Alo', Francesco (ORCID:0000-0003-3576-8522), Arena, Vincenzo (ORCID:0000-0002-7562-223X), Larocca, Luigi Maria (ORCID:0000-0003-1739-4758), Teofili, Luciana (ORCID:0000-0002-7214-1561), and Hohaus, Stefan (ORCID:0000-0002-5534-7197)

Published
2009

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