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182 results on '"Mansour, Eli"'

1. Three versions of an atopic dermatitis case report written by humans, artificial intelligence, or both: Identification of authorship and preferences

Author

Agondi, Rosana, Almeida, Stephanie K.A., Alves Junior, Wandilson Xavier, Armelin, Larissa M., Vivolo Aun, Marcelo, Bordignon, Natália, Boufleur, Karla, Brunheroto, Felipe B., Callegaro, Elisabeth A., Castro, Paula Lazaretti M., Chong-Neto, Herberto Jose, Dall’Osto, Mariana D., Abou Dias, Julia, Ferreira, Viviane Heintze, Oliveira Feodrippe, André Luiz, Fonseca, Livia G., Garcia, Clycia M., Giavina-Bianchi, Bruna H., Goudouris, Ekaterini, Gonçalves, Danilo Gois, Hernandes, Debora D., Imad, Malek, Izabel, Larissa S., Cauê Jacintho, Lucas, Khouri-Panzarin, Carolina, Kuschnir, Fabio, Pádua Lima, Maria Beatriz, Lopes, Amanda I., Macêdo Nóbrega Lopes, Larissa Nathalia, Rocha de Magalhães, Alice, Mansour, Eli, Marinho, Ana Karolina B.B., Martimiano, Vivian S., Milori, Pedro H., Marcondes Mutarelli, Antonio, Gonçalves Nogueira, Guilherme Paes, Oguido, Beatriz K.T., Alarcon de Oliveira, Bruna S., Costa de Oliveira, Emerson, Padulla, Georgia A., D’Ordaz Lhano Santos, Letícia, Meneses Santos, Micaelly Samara, Sarinho, Emanuel, Schoen, Marcela, Sousa, Brian Lucas A., Magalhães de Souza-Lima, Eduardo, Todt, Beatriz C., Braz da Silva Vaz, Najla, Giavina Bianchi, Mara, D’adario, Andrew, Giavina Bianchi, Pedro, and Machado, Birajara Soares

Published
2025
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2. Podoplanin and CLEC-2 levels in patients with COVID-19

Author

Borba-Junior, Ivanio Teixeira, Lima, Franciele, Sidarta-Oliveira, Davi, Moraes, Carla Roberta Peachazepi, Annichino-Bizzacchi, Joyce M., Bombassaro, Bruna, Palma, André C., Costa, Fábio Trindade Maranhão, Moretti, Maria Luiza, Mansour, Eli, Velloso, Lício Augusto, Orsi, Fernanda Andrade, and De Paula, Erich Vinicius

Published
2023
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3. Are pediatricians familiar with hereditary angioedema?

Author

Chong-Neto, Herberto José, Aroni, Bárbara Padilha, Mansour, Eli, Toledo, Eliana, Serpa, Faradiba Sarquis, Arruda, Luisa Karla, Giavina-Bianchi, Pedro, Valle, Solange Oliveira Rodrigues, de Moraes, Caroline Guth de Freitas Batista, Kruk, Tatielly, Chong-Silva, Débora Carla, Solé, Dirceu, Silva, Luciana Rodrigues, Grumach, Anete S., Rosário Filho, Nelson Augusto, and Campos, Régis de Albuquerque

Published
2023
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4. Contact and intrinsic coagulation pathways are activated and associated with adverse clinical outcomes in COVID-19

Author

Henderson, Michael W., Lima, Franciele, Moraes, Carla Roberta Peachazepi, Ilich, Anton, Huber, Stephany Cares, Barbosa, Mayck Silva, Santos, Irene, Palma, Andre C., Nunes, Thyago Alves, Ulaf, Raisa Gusso, Ribeiro, Luciana Costa, Bernardes, Ana Flavia, Bombassaro, Bruna, Dertkigil, Sergio San Juan, Moretti, Maria Luiza, Strickland, Sidney, Annichino-Bizzacchi, Joyce M., Orsi, Fernanda Andrade, Mansour, Eli, Velloso, Licio A., Key, Nigel S., and De Paula, Erich Vinicius

Published
2022
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5. Angiopoietin2 is associated with coagulation activation and tissue factor expression in extracellular vesicles in COVID-19

Author

Barbosa, Mayck Silva, primary, de Lima, Franciele, additional, Peachazepi Moraes, Carla Roberta, additional, Borba-Junior, Ivanio Teixeira, additional, Huber, Stephany Cares, additional, Santos, Irene, additional, Bombassaro, Bruna, additional, Dertkigil, Sergio San Juan, additional, Ilich, Anton, additional, Key, Nigel S., additional, Annichino-Bizzacchi, Joyce M., additional, Orsi, Fernanda Andrade, additional, Mansour, Eli, additional, Velloso, Licio A., additional, and De Paula, Erich Vinicius, additional

Published
2024
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6. Glycogen Storage Disease Type 1b

Author

Mansour, Eli, Sousa, Ana Flavia Bernardes, Condino-Neto, Antonio, Section editor, Orange, Jordan Scott, editor, Chinen, Javier, editor, MacKay, Ian R., Series Editor, and Rose, Noel R., Series Editor

Published
2020
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7. Outcome of SARS-CoV-2 Infection in 121 Patients with Inborn Errors of Immunity: A Cross-Sectional Study

Author

Goudouris, Ekaterini Simões, Pinto-Mariz, Fernanda, Mendonça, Leonardo Oliveira, Aranda, Carolina Sanchez, Guimarães, Rafaela Rolla, Kokron, Cristina, Barros, Myrthes Toledo, Anísio, Flávia, Alonso, Maria Luiza Oliva, Marcelino, Fernanda, Valle, Solange Oliveira Rodrigues, Junior, Sergio Dortas, Barreto, Irma Douglas Paes, Ferreira, Janáira Fernandes Severo, Roxo-Junior, Pérsio, do Rego Silva, Almerinda Maria, Campinhos, Fernanda Lugão, Bonfim, Carmem, Loth, Gisele, Fernandes, Juliana Folloni, Garcia, Julia Lopes, Capelo, Albertina, Takano, Olga Akiko, Nadaf, Maria Isabel Valdomir, Toledo, Eliana C., Cunha, Luciana Araújo Oliveira, Di Gesu, Regina Sumiko Watanabe, Schidlowski, Laire, Fillipo, Priscila, Bichuetti-Silva, Daniélli C., Soldateli, Gustavo, Ferraroni, Natasha Rebouças, de Oliveira Dantas, Ellen, Pestana, Simone, Mansour, Eli, Ulaf, Raisa Gusso, Prando, Carolina, Condino-Neto, Antonio, and Grumach, Anete Sevciovic

Published
2021
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8. The Panorama of Primary Angioedema in the Brazilian Population

Author

Cagini, Nathália, Mansour, Eli, da Silva, Jane, Giavina-Bianchi, Pedro, Teixeira, Ana Júlia, Valle, Solange Rodrigues, Goudouris, Ekaterini, Serpa, Faradiba Sarquis, Moyses, Therezinha R., Campinhos, Fernanda Lugão, Ensina, Luis Felipe, Aranda, Carolina Sánchez, Rizzo, Maria Cândida, Campos, Régis A., Gonçalves, Rozana Fátima, Minafra, Fernanda Gontijo, de Souza Bernardes, Marli, Chong-Neto, Herberto José, Filho, Nelson Rosário, Guth, Carolina, Toledo, Eliana, Coelho Dias, Gabriela Andrade, Piccirillo, Miguel Alberto, Severo Ferreira, Janáira Fernandes, Marcelino, Fernanda Casares, da Rocha Rolins Neto, Pedro, Franco, Jackeline Motta, Pafume de Sá, Gustavo, Garro, Laila Sabino, Carolina da Matta Ain, Ana, Velasco, Helena F., Fernandes Carvalho, Ellaine Dóris, Fernandes Carvalho de Andrade, Maria Denise, Boll, Cristiane Alves, Ferraroni, Natasha Rebouças, Martins Pinto Swensson, Ana Carolina, Vilela Rabelo, Leandro Augusto, Pacheco de Figueiredo, Joanemile, Figueredo, Raphael Coelho, Mendes, Ronney Corrêa, Sales, Valéria S.F., Bacarini Leite, Luiz Fernando, Beltran Moschione Castro, Ana Paula, Ferreira Mascarenhas, Elke C., Teixeira, Thais Bomfim, Campos Teixeira, Camila A., Pereira de Lira Marques, Adriana, Pires Amaral Resende, Ludmilla Luzia, Sandrin, Leda das Neves Almeida, Tavares, Clarissa Soares, Veronez, Camila Lopes, Mendes, Agatha Ribeiro, Leite, Caroliny Souza, Gomes, Caio Perez, Grumach, Anete Sevciovic, and Pesquero, João Bosco

Published
2021
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9. Cyclic Neutropenia

Author

Mansour, Eli, Bombassaro, Bruna, Condino-Neto, Antonio, Section editor, Orange, Jordan Scott, editor, Chinen, Javier, editor, MacKay, Ian R., Series Editor, and Rose, Noel R., Series Editor

Published
2020
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10. X-Linked Neutropenia/Myelodysplasia

Author

Mansour, Eli, Leite-Caldeira, Denise, Condino-Neto, Antonio, Section editor, Orange, Jordan Scott, editor, Chinen, Javier, editor, MacKay, Ian R., Series Editor, and Rose, Noel R., Series Editor

Published
2020
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11. The Effects of High‐Fat Diet and Flaxseed Oil‐Enriched Diet on the Lung Parenchyma of Obese Mice.

Author

Ramos, Camila de Oliveira, Sant'Ana, Marcella Ramos, Gonçalves, Giovana Rios, Rios, Thaiane da Silva, Nakandakari, Susana Castelo Branco Ramos, Burger, Beatriz, Fernandes, Luís Gustavo Romani, Zollner, Ricardo de Lima, de Oliveira, Arthur Noin, Ramos, Rodrigo Catharino, da Silva, Adelino Sanchez Ramos, Pauli, José Rodrigo, de Moura, Leandro Pereira, Ropelle, Eduardo Rochete, Mansour, Eli, and Cintra, Dennys Esper

Published
2024
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12. Rapid clinical recovery of a SARS-CoV-2 infected common variable immunodeficiency patient following the infusion of COVID-19 convalescent plasma

Author

Ribeiro, Luciana C., Benites, Bruno Deltreggia, Ulaf, Raisa G., Nunes, Thyago A., Costa-Lima, Carolina, Addas-Carvalho, Marcelo, Proenca-Modena, José Luiz, Granja, Fabiana, da Costa, Vitor Antonio, Duarte, Adriana da Silva Santos, Zangirolami, Audrey Basso, Amaro, Emerson Clayton, Mansour, Eli, Zollner, Ricardo L., and Velloso, Licio A.

Published
2021
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13. Evaluation of the efficacy and safety of icatibant and C1 esterase/kallikrein inhibitor in severe COVID-19: study protocol for a three-armed randomized controlled trial

Author

Mansour, Eli, Bueno, Flávia F., de Lima-Júnior, José C., Palma, Andre, Monfort-Pires, Milena, Bombassaro, Bruna, Araujo, Eliana P., Bernardes, Ana Flavia, Ulaf, Raisa G., Nunes, Thyago A., Ribeiro, Luciana C., Falcão, Antônio Luís E., Santos, Thiago Martins, Trabasso, Plinio, Dertkigil, Rachel P., Dertkigil, Sergio S., Maia, Rafael P., Benaglia, Tatiana, Moretti, Maria Luiza, and Velloso, Licio A.

Published
2021
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15. Angiopoietin2 is associated with coagulation activation and tissue factor expression in extracellular vesicles in COVID-19.

Author

Silva Barbosa, Mayck, de Lima, Franciele, Peachazepi Moraes, Carla Roberta, Teixeira Borba-Junior, Ivanio, Cares Huber, Stephany, Santos, Irene, Bombassaro, Bruna, San Juan Dertkigil, Sergio, Ilich, Anton, Key, Nigel S., Annichino-Bizzacchi, Joyce M., Andrade Orsi, Fernanda, Mansour, Eli, Velloso, Licio A., and Vinicius De Paula, Erich

Published
2024
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16. Hereditary Angioedema with Normal C1 Inhibitor and F12 Mutations in 42 Brazilian Families

Author

Veronez, Camila Lopes, Moreno, Adriana S., Constantino-Silva, Rosemeire Navickas, Maia, Luana S.M., Ferriani, Mariana P.L., Castro, Fábio F.M., Valle, Solange Rodrigues, Nakamura, Victor Koji, Cagini, Nathália, Gonçalves, Rozana Fátima, Mansour, Eli, Serpa, Faradiba Sarquis, Coelho Dias, Gabriela Andrade, Piccirillo, Miguel Alberto, Toledo, Eliana, de Souza Bernardes, Marli, Cichon, Sven, Stieber, Christiane, Arruda, L. Karla, Pesquero, João Bosco, and Grumach, Anete Sevciovic

Published
2018
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17. Brazilian Guidelines for Hereditary Angioedema Management - 2017 Update Part 1: Definition, Classification and Diagnosis

Author

Giavina-Bianchi, Pedro, Arruda, Luisa Karla, Aun, Marcelo V., Campos, Regis A., Chong-Neto, Herberto J., Constantino-Silva, Rosemeire N., Fernandes, Fátima R., Ferraro, Maria F., Ferriani, Mariana P.L., França, Alfeu T., Fusaro, Gustavo, Garcia, Juliana F.B., Komninakis, Shirley, Maia, Luana S.M., Mansour, Eli, Moreno, Adriana S., Motta, Antonio A., Pesquero, João B., Portilho, Nathalia, Rosário, Nelson A., Serpa, Faradiba S., Solé, Dirceu, Takejima, Priscila, Toledo, Eliana, Valle, Solange O.R., Veronez, Camila L., and Grumach, Anete S.

Published
2018
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18. A concept for integrated care pathways for atopic dermatitis—A GA2LEN ADCARE initiative

Author

Zuberbier, Torsten, primary, Abdul Latiff, Amir, additional, Aggelidis, Xenofon, additional, Augustin, Matthias, additional, Balan, Radu‐Gheorghe, additional, Bangert, Christine, additional, Beck, Lisa, additional, Bieber, Thomas, additional, Bernstein, Jonathan A., additional, Bertolin Colilla, Marta, additional, Berardi, Alejandro, additional, Bedbrook, Anna, additional, Bindslev‐Jensen, Carsten, additional, Bousquet, Jean, additional, de Bruin‐Weller, Marjolein, additional, Bruscky, Dayanne, additional, Buyuktiryaki, Betul, additional, Canonica, Giorgio Walter, additional, Castro, Carla, additional, Chanturidze, Natia, additional, Chong‐Neto, Herberto Jose, additional, Chu, Chia‐Yu, additional, Chularojanamontri, Leena, additional, Cork, Michael, additional, Criado, Roberta F. J., additional, Barredo, Laia Curto, additional, Custovic, Adnan, additional, Darsow, Ulf, additional, Emurlai, Arben, additional, de Pablo, Ana, additional, Del Giacco, Stefano, additional, Girolomoni, Giampiero, additional, Deleva Jovanova, Tanja, additional, Deleuran, Mette, additional, Douladiris, Nikolaos, additional, Duarte, Bruno, additional, Dubakiene, Ruta, additional, Eller, Esben, additional, Engel‐Yeger, Batya, additional, Ensina, Luis Felipe, additional, Filho, Nelson Rosario, additional, Flohr, Carsten, additional, Fomina, Daria, additional, Francuzik, Wojciech, additional, Galimberti, Maria Laura, additional, Giménez‐Arnau, Ana M., additional, Godse, Kiran, additional, Mortz, Charlotte Gotthard, additional, Gotua, Maia, additional, Hide, Michihiro, additional, Hoetzenecker, Wolfram, additional, Hunzelmann, Nicolas, additional, Irvine, Alan, additional, Jack, Carolyn, additional, Kanavarou, Ioanna, additional, Katoh, Norito, additional, Kinaciyan, Tamar, additional, Kocatürk, Emek, additional, Kulthanan, Kanokvalai, additional, Lapeere, Hilde, additional, Lau, Susanne, additional, Machado Forti Nastri, Mariana, additional, Makris, Michael, additional, Mansour, Eli, additional, Marsland, Alexander, additional, Morelo Rocha Felix, Mara, additional, Moschione Castro, Ana Paula, additional, Nettis, Eustachio, additional, Nicolas, J. F., additional, Nosbaum, Audrey, additional, Odemyr, Mikaela, additional, Papapostolou, Niki, additional, Parisi, Claudio A. S., additional, Paudel, Sushil, additional, Peter, Jonny, additional, Pokharel, Prakash, additional, Puig, Luis, additional, Quint, Tamara, additional, Ramon, German Dario, additional, Regateiro, Frederico, additional, Ricci, Giampaolo, additional, Rosario, Cristine, additional, Sackesen, Cansin, additional, Schmid‐Grendelmeier, Peter, additional, Serra‐Baldrich, Esther, additional, Siemens, Kristina, additional, Smith, Cathrine, additional, Staubach, Petra, additional, Stevanovic, Katarina, additional, Su‐Kücük, Özlem, additional, Sussman, Gordon, additional, Tavecchio, Simona, additional, Teovska Mitrevska, Natasa, additional, Thaci, Diamant, additional, Toubi, Elias, additional, Traidl‐Hoffmann, Claudia, additional, Treudler, Regina, additional, Vadasz, Zahava, additional, van Hofman, Ingrid, additional, Ventura, Maria Teresa, additional, Wang, Zhao, additional, Werfel, Thomas, additional, Wollenberg, Andreas, additional, Yang, Ariana, additional, Weng Yew, Yik, additional, Zhao, Zuotao, additional, Zwiener, Ricardo, additional, and Worm, Margitta, additional

Published
2023
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19. SARS-CoV-2 uses CD4 to infect T helper lymphocytes

Author

Brunetti, Natalia S, primary, Davanzo, Gustavo G, primary, de Moraes, Diogo, primary, Ferrari, Allan JR, primary, Souza, Gabriela F, primary, Muraro, Stéfanie Primon, primary, Knittel, Thiago L, primary, Boldrini, Vinicius O, primary, Monteiro, Lauar B, primary, Virgílio-da-Silva, João Victor, primary, Profeta, Gerson S, primary, Wassano, Natália S, primary, Nunes Santos, Luana, primary, Carregari, Victor C, primary, Dias, Artur HS, primary, Veras, Flavio P, additional, Tavares, Lucas A, additional, Forato, Julia, additional, Castro, Icaro MS, additional, Silva-Costa, Lícia C, additional, Palma, André C, additional, Mansour, Eli, additional, Ulaf, Raisa G, additional, Bernardes, Ana F, additional, Nunes, Thyago A, additional, Ribeiro, Luciana C, additional, Agrela, Marcus V, additional, Moretti, Maria Luiza, additional, Buscaratti, Lucas I, additional, Crunfli, Fernanda, additional, Ludwig, Raissa G, additional, Gerhardt, Jaqueline A, additional, Munhoz-Alves, Natália, additional, Marques, Ana Maria, additional, Sesti-Costa, Renata, additional, Amorim, Mariene R, additional, Toledo-Teixeira, Daniel A, additional, Parise, Pierina Lorencini, additional, Martini, Matheus Cavalheiro, additional, Bispos-dos-Santos, Karina, additional, Simeoni, Camila L, additional, Granja, Fabiana, additional, Silvestrini, Virgínia C, additional, de Oliveira, Eduardo B, additional, Faca, Vitor M, additional, Carvalho, Murilo, additional, Castelucci, Bianca G, additional, Pereira, Alexandre B, additional, Coimbra, Laís D, additional, Dias, Marieli MG, additional, Rodrigues, Patricia B, additional, Gomes, Arilson Bernardo SP, additional, Pereira, Fabricio B, additional, Santos, Leonilda MB, additional, Bloyet, Louis-Marie, additional, Stumpf, Spencer, additional, Pontelli, Marjorie C, additional, Whelan, Sean, additional, Sposito, Andrei C, additional, Carvalho, Robson F, additional, Vieira, André S, additional, Vinolo, Marco AR, additional, Damasio, André, additional, Velloso, Licio, additional, Figueira, Ana Carolina M, additional, da Silva, Luis LP, additional, Cunha, Thiago Mattar, additional, Nakaya, Helder I, additional, Marques-Souza, Henrique, additional, Marques, Rafael E, additional, Martins-de-Souza, Daniel, additional, Skaf, Munir S, additional, Proenca-Modena, Jose Luiz, additional, Moraes-Vieira, Pedro MM, additional, Mori, Marcelo A, additional, and Farias, Alessandro S, additional

Published
2023
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23. Author response: SARS-CoV-2 uses CD4 to infect T helper lymphocytes

Author

Brunetti, Natalia S, primary, Davanzo, Gustavo G, primary, de Moraes, Diogo, primary, Ferrari, Allan JR, primary, Souza, Gabriela F, primary, Muraro, Stéfanie Primon, primary, Knittel, Thiago L, primary, Boldrini, Vinicius O, primary, Monteiro, Lauar B, primary, Virgílio-da-Silva, João Victor, primary, Profeta, Gerson S, primary, Wassano, Natália S, primary, Nunes Santos, Luana, primary, Carregari, Victor C, primary, Dias, Artur HS, primary, Veras, Flavio P, additional, Tavares, Lucas A, additional, Forato, Julia, additional, Castro, Icaro MS, additional, Silva-Costa, Lícia C, additional, Palma, André C, additional, Mansour, Eli, additional, Ulaf, Raisa G, additional, Bernardes, Ana F, additional, Nunes, Thyago A, additional, Ribeiro, Luciana C, additional, Agrela, Marcus V, additional, Moretti, Maria Luiza, additional, Buscaratti, Lucas I, additional, Crunfli, Fernanda, additional, Ludwig, Raissa G, additional, Gerhardt, Jaqueline A, additional, Munhoz-Alves, Natália, additional, Marques, Ana Maria, additional, Sesti-Costa, Renata, additional, Amorim, Mariene R, additional, Toledo-Teixeira, Daniel A, additional, Parise, Pierina Lorencini, additional, Martini, Matheus Cavalheiro, additional, Bispos-dos-Santos, Karina, additional, Simeoni, Camila L, additional, Granja, Fabiana, additional, Silvestrini, Virgínia C, additional, de Oliveira, Eduardo B, additional, Faca, Vitor M, additional, Carvalho, Murilo, additional, Castelucci, Bianca G, additional, Pereira, Alexandre B, additional, Coimbra, Laís D, additional, Dias, Marieli MG, additional, Rodrigues, Patricia B, additional, Gomes, Arilson Bernardo SP, additional, Pereira, Fabricio B, additional, Santos, Leonilda MB, additional, Bloyet, Louis-Marie, additional, Stumpf, Spencer, additional, Pontelli, Marjorie C, additional, Whelan, Sean, additional, Sposito, Andrei C, additional, Carvalho, Robson F, additional, Vieira, André S, additional, Vinolo, Marco AR, additional, Damasio, André, additional, Velloso, Licio, additional, Figueira, Ana Carolina M, additional, da Silva, Luis LP, additional, Cunha, Thiago Mattar, additional, Nakaya, Helder I, additional, Marques-Souza, Henrique, additional, Marques, Rafael E, additional, Martins-de-Souza, Daniel, additional, Skaf, Munir S, additional, Proenca-Modena, Jose Luiz, additional, Moraes-Vieira, Pedro MM, additional, Mori, Marcelo A, additional, and Farias, Alessandro S, additional

Published
2023
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24. A concept for integrated care pathways for atopic dermatitis- a GA2LEN ADCARE initiative

Author

Büyüktiryaki, Ayşe Betül (ORCID 0000-0003-1206-969X & YÖK ID 195944); Göncü, Özgür Emek Kocatürk (ORCID 0000-0003-2801-0959 & YÖK ID 217219); Saçkesen, Cansın (ORCID 0000-0002-1115-9805 & YÖK ID 182537), Zuberbier, Torsten; Abdul Latiff, Amir; Aggelidis, Xenofon; Augustin, Matthias; Balan, Radu-Gheorghe; Bangert, Christine; Beck, Lisa; Bieber, Thomas; Bernstein, Jonathan A.; Bertolin Colilla, Marta; Berardi, Alejandro; Bedbrook, Anna; Bindslev-Jensen, Carsten; Bousquet, Jean; de Bruin-Weller, Marjolein; Bruscky, Dayanne; Canonica, Giorgio Walter; Castro, Carla; Chanturidze, Natia; Chong-Neto, Herberto Jose; Chu, Chia-Yu; Chularojanamontri, Leena; Cork, Michael; Criado, Roberta F. J.; Barredo, Laia Curto; Custovic, Adnan; Darsow, Ulf; Emurlai, Arben; de Pablo, Ana; Del Giacco, Stefano; Girolomoni, Giampiero; Deleva Jovanova, Tanja; Deleuran, Mette; Douladiris, Nikolaos; Duarte, Bruno; Dubakiene, Ruta; Eller, Esben; Engel-Yeger, Batya; Ensina, Luis Felipe; Rosario Filho, Nelson; Flohr, Carsten; Fomina, Daria; Francuzik, Wojciech; Galimberti, Maria Laura; Gimenez-Arnau, Ana M.; Godse, Kiran; Mortz, Charlotte Gotthard; Gotua, Maia; Hide, Michihiro; Hoetzenecker, Wolfram; Hunzelmann, Nicolas; Irvine, Alan; Jack, Carolyn; Kanavarou, Ioanna; Katoh, Norito; Kinaciyan, Tamar; Kulthanan, Kanokvalai; Lapeere, Hilde; Lau, Susanne; Machado Forti Nastri, Mariana; Makris, Michael; Mansour, Eli; Marsland, Alexander; Morelo Rocha Felix, Mara; Moschione Castro, Ana Paula; Nettis, Eustachio; Nicolas, J. F.; Nosbaum, Audrey; Odemyr, Mikaela; Papapostolou, Niki; Parisi, Claudio A. S.; Paudel, Sushil; Peter, Jonny; Pokharel, Prakash; Puig, Luis; Quint, Tamara; Ramon, German Dario; Regateiro, Frederico; Ricci, Giampaolo; Rosario, Cristine; Schmid-Grendelmeier, Peter; Serra-Baldrich, Esther; Siemens, Kristina; Smith, Cathrine; Staubach, Petra; Stevanovic, Katarina; Su-Kucuk, Ozlem; Sussman, Gordon; Tavecchio, Simona; Teovska Mitrevska, Natasa; Thaci, Diamant; Toubi, Elias; Traidl-Hoffmann, Claudia; Treudler, Regina; Vadasz, Zahava; van Hofman, Ingrid; Ventura, Maria Teresa; Wang, Zhao; Werfel, Thomas; Wollenberg, Andreas; Yang, Ariana; Weng Yew, Yik; Zhao, Zuotao; Zwiener, Ricardo; Worm, M, Koç University Hospital, School of Medicine, Büyüktiryaki, Ayşe Betül (ORCID 0000-0003-1206-969X & YÖK ID 195944); Göncü, Özgür Emek Kocatürk (ORCID 0000-0003-2801-0959 & YÖK ID 217219); Saçkesen, Cansın (ORCID 0000-0002-1115-9805 & YÖK ID 182537), Zuberbier, Torsten; Abdul Latiff, Amir; Aggelidis, Xenofon; Augustin, Matthias; Balan, Radu-Gheorghe; Bangert, Christine; Beck, Lisa; Bieber, Thomas; Bernstein, Jonathan A.; Bertolin Colilla, Marta; Berardi, Alejandro; Bedbrook, Anna; Bindslev-Jensen, Carsten; Bousquet, Jean; de Bruin-Weller, Marjolein; Bruscky, Dayanne; Canonica, Giorgio Walter; Castro, Carla; Chanturidze, Natia; Chong-Neto, Herberto Jose; Chu, Chia-Yu; Chularojanamontri, Leena; Cork, Michael; Criado, Roberta F. J.; Barredo, Laia Curto; Custovic, Adnan; Darsow, Ulf; Emurlai, Arben; de Pablo, Ana; Del Giacco, Stefano; Girolomoni, Giampiero; Deleva Jovanova, Tanja; Deleuran, Mette; Douladiris, Nikolaos; Duarte, Bruno; Dubakiene, Ruta; Eller, Esben; Engel-Yeger, Batya; Ensina, Luis Felipe; Rosario Filho, Nelson; Flohr, Carsten; Fomina, Daria; Francuzik, Wojciech; Galimberti, Maria Laura; Gimenez-Arnau, Ana M.; Godse, Kiran; Mortz, Charlotte Gotthard; Gotua, Maia; Hide, Michihiro; Hoetzenecker, Wolfram; Hunzelmann, Nicolas; Irvine, Alan; Jack, Carolyn; Kanavarou, Ioanna; Katoh, Norito; Kinaciyan, Tamar; Kulthanan, Kanokvalai; Lapeere, Hilde; Lau, Susanne; Machado Forti Nastri, Mariana; Makris, Michael; Mansour, Eli; Marsland, Alexander; Morelo Rocha Felix, Mara; Moschione Castro, Ana Paula; Nettis, Eustachio; Nicolas, J. F.; Nosbaum, Audrey; Odemyr, Mikaela; Papapostolou, Niki; Parisi, Claudio A. S.; Paudel, Sushil; Peter, Jonny; Pokharel, Prakash; Puig, Luis; Quint, Tamara; Ramon, German Dario; Regateiro, Frederico; Ricci, Giampaolo; Rosario, Cristine; Schmid-Grendelmeier, Peter; Serra-Baldrich, Esther; Siemens, Kristina; Smith, Cathrine; Staubach, Petra; Stevanovic, Katarina; Su-Kucuk, Ozlem; Sussman, Gordon; Tavecchio, Simona; Teovska Mitrevska, Natasa; Thaci, Diamant; Toubi, Elias; Traidl-Hoffmann, Claudia; Treudler, Regina; Vadasz, Zahava; van Hofman, Ingrid; Ventura, Maria Teresa; Wang, Zhao; Werfel, Thomas; Wollenberg, Andreas; Yang, Ariana; Weng Yew, Yik; Zhao, Zuotao; Zwiener, Ricardo; Worm, M, Koç University Hospital, and School of Medicine

Abstract

Introduction: The integrated care pathways for atopic dermatitis (AD-ICPs) aim to bridge the gap between existing AD treatment evidence-based guidelines and expert opinion based on daily practice by offering a structured multidisciplinary plan for patient management of AD. ICPs have the potential to enhance guideline recommendations by combining interventions and aspects from different guidelines, integrating quality assurance, and describing co-ordination of care. Most importantly, patients can enter the ICPs at any level depending on AD severity, resources available in their country, and economic factors such as differences in insurance reimbursement systems.Methods: The GA(2)LEN ADCARE network and partners as well as all stakeholders, abbreviated as the AD-ICPs working group, were involved in the discussion and preparation of the AD ICPs during a series of subgroup workshops and meetings in years 2020 and 2021, after which the document was circulated within all GAL(2)EN ADCARE centres.Results: The AD-ICPs outline the diagnostic procedures, possible co-morbidities, different available treatment options including differential approaches for the pediatric population, and the role of the pharmacists and other stakeholders, as well as remaining unmet needs in the management of AD.Conclusion: The AD-ICPs provide a multidisciplinary plan for improved diagnosis, treatment, and patient feedback in AD management, as well as addressing critical unmet needs, including improved access to care, training specialists, implementation of educational programs, assessment on the impact of climate change, and fostering a personalised treatment approach. By focusing on these key areas, the initiative aims to pave the way for a brighter future in the management of AD., We thank the industry partners from the companies Almirall, AbbVie, Galderma, Novartis, Sanofi, and Thermo Fisher for taking part in the discussion on the atopic dermatitis-Integrated Care Pathways development during the AD-ICPs working group meetings. Open Access funding enabled and organized by Projekt DEAL.

Published
2023

25. SARS-CoV-2 uses CD4 to infect T helper lymphocytes

Author

Brunetti, Natalia S, Davanzo, Gustavo G, de Moraes, Diogo, Ferrari, Allan JR, Souza, Gabriela F, Muraro, Stéfanie Primon, Knittel, Thiago L, Boldrini, Vinicius O, Monteiro, Lauar B, Virgílio-da-Silva, João Victor, Profeta, Gerson S, Wassano, Natália S, Nunes Santos, Luana, Carregari, Victor C, Dias, Artur HS, Veras, Flavio P, Tavares, Lucas A, Forato, Julia, Castro, Icaro MS, Silva-Costa, Lícia C, Palma, André C, Mansour, Eli, Ulaf, Raisa G, Bernardes, Ana F, Nunes, Thyago A, Ribeiro, Luciana C, Agrela, Marcus V, Moretti, Maria Luiza, Buscaratti, Lucas I, Crunfli, Fernanda, Ludwig, Raissa G, Gerhardt, Jaqueline A, Munhoz-Alves, Natália, Marques, Ana Maria, Sesti-Costa, Renata, Amorim, Mariene R, Toledo-Teixeira, Daniel A, Parise, Pierina Lorencini, Martini, Matheus Cavalheiro, Bispos-dos-Santos, Karina, Simeoni, Camila L, Granja, Fabiana, Silvestrini, Virgínia C, de Oliveira, Eduardo B, Faca, Vitor M, Carvalho, Murilo, Castelucci, Bianca G, Pereira, Alexandre B, Coimbra, Laís D, Dias, Marieli MG, Rodrigues, Patricia B, Gomes, Arilson Bernardo SP, Pereira, Fabricio B, Santos, Leonilda MB, Bloyet, Louis-Marie, Stumpf, Spencer, Pontelli, Marjorie C, Whelan, Sean, Sposito, Andrei C, Carvalho, Robson F, Vieira, André S, Vinolo, Marco AR, Damasio, André, Velloso, Licio, Figueira, Ana Carolina M, da Silva, Luis LP, Cunha, Thiago Mattar, Nakaya, Helder I, Marques-Souza, Henrique, Marques, Rafael E, Martins-de-Souza, Daniel, Skaf, Munir S, Proenca-Modena, Jose Luiz, Moraes-Vieira, Pedro MM, Mori, Marcelo A, Farias, Alessandro S, Brunetti, Natalia S, Davanzo, Gustavo G, de Moraes, Diogo, Ferrari, Allan JR, Souza, Gabriela F, Muraro, Stéfanie Primon, Knittel, Thiago L, Boldrini, Vinicius O, Monteiro, Lauar B, Virgílio-da-Silva, João Victor, Profeta, Gerson S, Wassano, Natália S, Nunes Santos, Luana, Carregari, Victor C, Dias, Artur HS, Veras, Flavio P, Tavares, Lucas A, Forato, Julia, Castro, Icaro MS, Silva-Costa, Lícia C, Palma, André C, Mansour, Eli, Ulaf, Raisa G, Bernardes, Ana F, Nunes, Thyago A, Ribeiro, Luciana C, Agrela, Marcus V, Moretti, Maria Luiza, Buscaratti, Lucas I, Crunfli, Fernanda, Ludwig, Raissa G, Gerhardt, Jaqueline A, Munhoz-Alves, Natália, Marques, Ana Maria, Sesti-Costa, Renata, Amorim, Mariene R, Toledo-Teixeira, Daniel A, Parise, Pierina Lorencini, Martini, Matheus Cavalheiro, Bispos-dos-Santos, Karina, Simeoni, Camila L, Granja, Fabiana, Silvestrini, Virgínia C, de Oliveira, Eduardo B, Faca, Vitor M, Carvalho, Murilo, Castelucci, Bianca G, Pereira, Alexandre B, Coimbra, Laís D, Dias, Marieli MG, Rodrigues, Patricia B, Gomes, Arilson Bernardo SP, Pereira, Fabricio B, Santos, Leonilda MB, Bloyet, Louis-Marie, Stumpf, Spencer, Pontelli, Marjorie C, Whelan, Sean, Sposito, Andrei C, Carvalho, Robson F, Vieira, André S, Vinolo, Marco AR, Damasio, André, Velloso, Licio, Figueira, Ana Carolina M, da Silva, Luis LP, Cunha, Thiago Mattar, Nakaya, Helder I, Marques-Souza, Henrique, Marques, Rafael E, Martins-de-Souza, Daniel, Skaf, Munir S, Proenca-Modena, Jose Luiz, Moraes-Vieira, Pedro MM, Mori, Marcelo A, and Farias, Alessandro S

Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the agent of a major global outbreak of respiratory tract disease known as Coronavirus Disease 2019 (COVID-19). SARS-CoV-2 infects mainly lungs and may cause several immune-related complications, such as lymphocytopenia and cytokine storm, which are associated with the severity of the disease and predict mortality. The mechanism by which SARS-CoV-2 infection may result in immune system dysfunction is still not fully understood. Here, we show that SARS-CoV-2 infects human CD4+ T helper cells, but not CD8+ T cells, and is present in blood and bronchoalveolar lavage T helper cells of severe COVID-19 patients. We demonstrated that SARS-CoV-2 spike glycoprotein (S) directly binds to the CD4 molecule, which in turn mediates the entry of SARS-CoV-2 in T helper cells. This leads to impaired CD4 T cell function and may cause cell death. SARS-CoV-2-infected T helper cells express higher levels of IL-10, which is associated with viral persistence and disease severity. Thus, CD4-mediated SARS-CoV-2 infection of T helper cells may contribute to a poor immune response in COVID-19 patients.

Published
2023

26. Association of Ang/Tie2 pathway mediators with endothelial barrier integrity and disease severity in COVID-19

Author

Moraes, Carla Roberta Peachazepi, primary, Borba-Junior, Ivanio Teixeira, additional, De Lima, Franciele, additional, Silva, Jéssica Ribeiro Alves, additional, Bombassaro, Bruna, additional, Palma, André C., additional, Mansour, Eli, additional, Velloso, Lício Augusto, additional, Orsi, Fernanda Andrade, additional, Costa, Fábio Trindade Maranhão, additional, and De Paula, Erich Vinicius, additional

Published
2023
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27. Association of heme-oxygenase 1, hemopexin, and heme levels with markers of disease severity in COVID-19

Author

de Lima, Franciele, primary, Moraes, Carla Roberta Peachazepi, additional, Barbosa, Mayck Silva, additional, Bombassaro, Bruna, additional, Palma, André C, additional, Dertkigil, Sergio San Juan, additional, Moretti, Maria Luiza, additional, Orsi, Fernanda Andrade, additional, Annichino-Bizzacchi, Joyce M, additional, Mansour, Eli, additional, Velloso, Licio A, additional, and De Paula, Erich Vinicius, additional

Published
2023
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31. Plasma Angiotensin II Is Increased in Critical Coronavirus Disease 2019

Author

Camargo, Rafael L., primary, Bombassaro, Bruna, additional, Monfort-Pires, Milena, additional, Mansour, Eli, additional, Palma, Andre C., additional, Ribeiro, Luciana C., additional, Ulaf, Raisa G., additional, Bernardes, Ana Flavia, additional, Nunes, Thyago A., additional, Agrela, Marcus V., additional, Dertkigil, Rachel P., additional, Dertkigil, Sergio S., additional, Araujo, Eliana P., additional, Nadruz, Wilson, additional, Moretti, Maria Luiza, additional, Velloso, Licio A., additional, and Sposito, Andrei C., additional

Published
2022
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32. Increased Serum Mir-150-3p Expression Is Associated with Radiological Lung Injury Improvement in Patients with COVID-19

Author

Bueno, Larissa C. M., primary, Paim, Layde R., additional, Minin, Eduarda O. Z., additional, da Silva, Luís Miguel, additional, Mendes, Paulo R., additional, Kiyota, Tatiana A., additional, Schreiber, Angelica Z., additional, Bombassaro, Bruna, additional, Mansour, Eli, additional, Moretti, Maria Luiza, additional, Chow, Jonathan Tak-Sum, additional, Salmena, Leonardo, additional, Coelho-Filho, Otavio R., additional, Velloso, Licio A., additional, Nadruz, Wilson, additional, and Schreiber, Roberto, additional

Published
2022
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34. COVID-19 triggers attacks in HAE patients without worsening disease outcome

Author

Olivares, María Margarita, Zwiener, Ricardo Dario, Panqueva, Lina Maria Leiva, Contreras Verduzco, Francisco Alberto, Mansour, Eli, Rodriguez, Jairo Antonio, Valle, Solange Oliveira Rodrigues, Nieto-Martínez, Sandra, da Silva, Jane, Vazquez, Daniel O., Llosa, Oscar Calderon, Marcelino, Fernanda Casares, Sisa, Manuel Ratti, Beas, Ileana María Madrigal, Urdaz, Rafael Zaragoza, Toledo, Eliana, Fili, Natalia Lorena, Barrera, Olga M., Aguirre, Juan Carlos Fernandez de Cordova, Mora, Sergio Castro, Sarrazola, Mauricio, Raad, Rodolfo Jaller, Cardenas, Edison Morales, Josviack, Dario Oscar, Fantini, Claudio, Marocco, Monica, Nievas, Elma I., Serpa, Faradiba Sarquis, Chong-Neto, Herberto J., Oliva Alonso, Maria Luiza, Dortas Junior, Sergio, Ulaf, Raisa Gusso, Rosário, Nelson, Leyva Barrero, Rodolfo Ramón, and Grumach, Anete Sevciovic

Published
2022
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35. Acquired Angioedema due to C1-Inhibitor Deficiency: A Challenging Condition

Author

Valle, Solange Oliveira Rodrigues, primary, Alonso, Maria Luiza Oliva, additional, Dortas Junior, Sérgio Duarte, additional, Goudouris, Ekaterini Simões, additional, de Carvalho, Ana Luiza Ribeiro Bard, additional, Capelo, Albertina Varandas, additional, Mansour, Eli, additional, Bernardes, Ana Flávia, additional, Leite, Luiz Fernando Bacarini, additional, Giavina-Bianchi, Pedro, additional, Aun, Marcelo Vivolo, additional, Ferriani, Mariana Paes Leme, additional, Arruda, Luisa Karla, additional, and Grumach, Anete Sevciovic, additional

Published
2022
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36. Practical guide to acute urticaria

Author

Alcântara, Carolina Tavares de, primary, Raeder, Daniela Farah Teixeira, additional, Campinhos, Fernanda Lugao, additional, Brandão, Larissa Silva, additional, Campos, Régis de Albuquerque, additional, Franca, Alfeu Tavares, additional, Gonçalves, Rozana de Fátima, additional, Mansour, Eli, additional, Melo, Janaina Michelle Lima, additional, Valle, Solange Oliveira Rodrigues, additional, Dias, Gabriela Andrade, additional, Trancoso-Neves, Leila Vieira Borges, additional, Agondi, Rosana Câmara, additional, and Ensina, Luis Felipe Chiaverini, additional

Published
2022
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37. Practical guide to urticaria for special patient groups

Author

Brandão, Larissa Silva, primary, Melo, Janaina Michelle Lima, additional, Dias, Gabriela Andrade, additional, Mansour, Eli, additional, Gonçalves, Rozana de Fátima, additional, De-Alcântara, Carolina Tavares, additional, Campinhos, Fernanda Lugao, additional, Raeder, Daniela Farah Teixeira, additional, Trancoso-Neves, Leila Vieira Borges, additional, Campos, Régis de Albuquerque, additional, Valle, Solange Oliveira Rodrigues, additional, Agondi, Rosana Câmara, additional, Franca, Alfeu Tavares, additional, and Ensina, Luis Felipe Chiaverini, additional

Published
2022
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38. 2022 Brazilian guidelines for hereditary angioedema - Part 1: definition, classification, and diagnosis

Author

Campos, Régis A., primary, Serpa, Faradiba Sarquis, additional, Mansour, Eli, additional, Alonso, Maria Luiza Oliva, additional, Arruda, Luisa Karla, additional, Aun, Marcelo Vivolo, additional, Bardou, Maine Luellah Demaret, additional, Bernardes, Ana Flávia, additional, Campinhos, Fernanda Lugão, additional, Chong-Neto, Herberto Jose, additional, Constantino-Silva, Rosemeire Navickas, additional, Silva, Jane da, additional, Dortas-Junior, Sérgio Duarte, additional, Ferriani, Mariana Paes Leme, additional, Figueiredo, Joanemile Pacheco de, additional, Giavina-Bianchi, Pedro, additional, Gomes, Lais Souza, additional, Goudouris, Ekaterini, additional, Grumach, Anete Sevciovic, additional, Henriques, Marina Teixeira, additional, Motta, Antônio Abilio, additional, Moyses, Therezinha Ribeiro, additional, Nunes, Fernanda Leonel, additional, Pinto, Jorge A., additional, Rosario-Filho, Nelson Augusto, additional, Rubini, Norma de Paula M., additional, Silva, Almerinda Maria do Rêgo, additional, Solé, Dirceu, additional, Teixeira, Ana Julia Ribeiro, additional, Toledo, Eliana, additional, Veronez, Camila Lopes, additional, and Valle, Solange Oliveira Rodrigues, additional

Published
2022
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39. 2022 Brazilian guidelines for hereditary angioedema - Part 2: therapy

Author

Campos, Régis A., primary, Serpa, Faradiba Sarquis, additional, Mansour, Eli, additional, Alonso, Maria Luiza Oliva, additional, Arruda, Luisa Karla, additional, Aun, Marcelo Vivolo, additional, Bardou, Maine Luellah Demaret, additional, Bernardes, Ana Flávia, additional, Campinhos, Fernanda Lugão, additional, Chong-Neto, Herberto Jose, additional, Constantino-Silva, Rosemeire Navickas, additional, Silva, Jane da, additional, Dortas-Junior, Sérgio Duarte, additional, Ferriani, Mariana Paes Leme, additional, Figueiredo, Joanemile Pacheco de, additional, Giavina-Bianchi, Pedro, additional, Gomes, Lais Souza, additional, Goudouris, Ekaterini, additional, Grumach, Anete Sevciovic, additional, Henriques, Marina Teixeira, additional, Motta, Antônio Abilio, additional, Moyses, Therezinha Ribeiro, additional, Nunes, Fernanda Leonel, additional, Pinto, Jorge A., additional, Rosario-Filho, Nelson Augusto, additional, Rubini, Norma de Paula M., additional, Silva, Almerinda Maria do Rêgo, additional, Solé, Dirceu, additional, Teixeira, Ana Julia Ribeiro, additional, Toledo, Eliana, additional, Veronez, Camila Lopes, additional, and Valle, Solange Oliveira Rodrigues, additional

Published
2022
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40. First Report of the Hyper-IgM Syndrome Registry of the Latin American Society for Immunodeficiencies: Novel Mutations, Unique Infections, and Outcomes

Author

Cabral-Marques, Otavio, Klaver, Stefanie, Schimke, Lena F, Ascendino, Évelyn H, Khan, Taj Ali, Pereira, Paulo Vítor Soeiro, Falcai, Angela, Vargas-Hernández, Alexander, Santos-Argumedo, Leopoldo, Bezrodnik, Liliana, Moreira, Ileana, Seminario, Gisela, Di Giovanni, Daniela, Raccio, Andrea Gómez, Porras, Oscar, Weber, Cristina Worm, Ferreira, Janaíra Fernandes, Tavares, Fabiola Scancetti, de Carvalho, Elisa, Valente, Claudia França Cavalcante, Kuntze, Gisele, Galicchio, Miguel, King, Alejandra, Rosário-Filho, Nelson Augusto, Grota, Milena Baptistella, dos Santos Vilela, Maria Marluce, Di Gesu, Regina Sumiko Watanabe, Lima, Simone, de Souza Moura, Leiva, Talesnik, Eduardo, Mansour, Eli, Roxo-Junior, Pérsio, Aldave, Juan Carlos, Goudouris, Ekaterine, Pinto-Mariz, Fernanda, Berrón-Ruiz, Laura, Staines-Boone, Tamara, Calderón, Wilmer O. Córdova, del Carmen Zarate-Hernández, María, Grumach, Anete S., Sorensen, Ricardo, Durandy, Anne, Torgerson, Troy R., Carvalho, Beatriz Tavares Costa, Espinosa-Rosales, Francisco, Ochs, Hans D., and Condino-Neto, Antonio

Published
2014
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43. Association of Ang/Tie2 pathway mediators with endothelial barrier integrity and disease severity in COVID-19.

Author

Peachazepi Moraes, Carla Roberta, Teixeira Borba-Junior, Ivanio, De Lima, Franciele, Alves Silva, Jéssica Ribeiro, Bombassaro, Bruna, Palma, André C., Mansour, Eli, Augusto Velloso, Lício, Andrade Orsi, Fernanda, Maranhão Costa, Fábio Trindade, and Vinicius De Paula, Erich

Subjects
COVID-19, LUNG injuries, ENDOTHELIAL cells, HOSPITAL admission & discharge, DRUG target
Abstract

Endothelial barrier (EB) disruption contributes to acute lung injury in COVID-19, and levels of both VEGF-A and Ang-2, which are mediators of EB integrity, have been associated with COVID-19 severity. Here we explored the participation of additional mediators of barrier integrity in this process, as well as the potential of serum from COVID-19 patients to induce EB disruption in cell monolayers. In a cohort from a clinical trial consisting of thirty patients with COVID-19 that required hospital admission due to hypoxia we demonstrate that i) levels of soluble Tie2 were increase, and of soluble VE-cadherin were decreased when compared to healthy individuals; ii) sera from these patients induce barrier disruption in monolayers of endothelial cells; and iii) that the magnitude of this effect is proportional to disease severity and to circulating levels of VEGF-A and Ang-2. Our study confirms and extends previous findings on the pathogenesis of acute lung injury in COVID-19, reinforcing the concept that EB is a relevant component of this disease. Our results pave the way for future studies that can refine our understanding of the pathogenesis of acute lung injury in viral respiratory disorders, and contribute to the identification of new biomarkers and therapeutic targets for these conditions. [ABSTRACT FROM AUTHOR]

Published
2023
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44. Circulating Levels of Ang/Tie2 and VEGF-a Pathway Mediators Are Associated with Clinical Severity, Endothelial Barrier Disruption and Coagulation Activation in COVID-19

Author

de Moraes, Carla Roberta Peachazepi, primary, de Borba Junior, Ivanio Teixeira, additional, de Lima, Franciele, additional, Barbosa, Mayck Silva, additional, Huber, Stephany Cares, additional, Palma, Andre C., additional, Nunes, Thyago A., additional, Ulaf, Raisa G., additional, Ribeiro, Luciana C., additional, Bernandes, Ana Flavia, additional, Bombassaro, Bruna, additional, Dertkigil, Sergio S., additional, Moretti, Maria Luiza, additional, Bizzacchi, Joyce Annichino, additional, Mansour, Eli, additional, Velloso, Lício Augusto, additional, Maranhão Costa, Fábio Trindade, additional, Orsi, Fernanda Andrade, additional, and De Paula, Erich V, additional

Published
2021
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45. Hereditary angioedema: how to approach it at the emergency department?

Author

Serpa, Faradiba Sarquis, Mansour, Eli, Aun, Marcelo Vivolo, Giavina-Bianchi, Pedro, Chong Neto, Herberto José, Arruda, Luisa Karla, Campos, Regis Albuquerque, Motta, Antônio Abílio, Toledo, Eliana, Grumach, Anete Sevciovic, and Valle, Solange Oliveira Rodrigues

Subjects
Abdominal pain, Edema laríngeo, Asfixia, Laryngeal edema, Inibidor de C1, C1-inhibitor, Dor abdominal, Bradykinin, Asphyxia, immune system diseases, Emergências, Angioedemas, hereditary, cardiovascular diseases, Angioedema, Emergencies, skin and connective tissue diseases, Bradicinina, Angioedemas hereditários
Abstract

Angioedema attacks are common causes of emergency care, and due to the potential for severity, it is important that professionals who work in these services know their causes and management. The mechanisms involved in angioedema without urticaria may be histamine- or bradykinin-mediated. The most common causes of histamine-mediated angioedema are foods, medications, insect sting and idiopathic. When the mediator is bradykinin, the triggers are angiotensin-converting enzyme inhibitors and factors related to acquired angioedema with deficiency of C1-inhibitor or hereditary angioedema, which are less common, but very important because of the possibility of fatal outcome. Hereditary angioedema is a rare disease characterized by attacks of edema that affect the subcutaneous tissue and mucous membranes of various organs, manifesting mainly by angioedema and abdominal pain. This type of angioedema does not respond to the usual treatment with epinephrine, antihistamines and corticosteroids. Thus, if not identified and treated appropriately, these patients have an estimated risk of mortality from laryngeal edema of 25% to 40%. Hereditary angioedema treatment has changed dramatically in recent years with the development of new and efficient drugs for attack management: plasma-derived C1 inhibitor, recombinant human C1-inhibitor, bradykinin B2 receptor antagonist (icatibant), and the kallikrein inhibitor (ecallantide). In Brazil, plasma-derived C1 inhibitor and icatibant have already been approved for use. Proper management of these patients in the emergency department avoids unnecessary surgery and, especially, fatal outcomes. RESUMO As crises de angioedema são causas comuns de atendimentos nas emergências, e devido ao potencial de gravidade, é importante que os profissionais que atuam nesses serviços conheçam suas causas e abordagem. Os mecanismos envolvidos no angioedema sem urticas podem ser histaminérgicos ou mediados por bradicinina. As causas mais comuns de angioedema mediado por histamina são alimentos, medicamentos, ferroada de insetos e idiopática. Quando o mediador é a bradicinina, os desencadeantes são os inibidores da enzima conversora de angiotensina e fatores relacionados ao angioedema adquirido com deficiência do inibidor de C1 ou angioedema hereditário que são menos comuns, mas muito importantes pela possibilidade de desfecho fatal. O angioedema hereditário é uma doença rara, caracterizada por crises de edema que acometem o tecido subcutâneo e mucosas de vários órgãos, manifestando-se principalmente por crises de angioedema e dor abdominal. Esse tipo de angioedema não responde ao tratamento usual com adrenalina, anti-histamínicos e corticosteroides. Assim, se não identificados e tratados adequadamente, esses pacientes têm risco de morte por edema de laringe estimado em 25% a 40%. O tratamento do angioedema hereditário mudou drasticamente nos últimos anos, com o desenvolvimento de novos e eficientes fármacos para as crises: inibidor de C1 derivado de plasma, inibidor de C1 recombinante humano, antagonista do receptor B2 da bradicinina (icatibanto) e o inibidor da calicreína (ecalantide). No Brasil, até o momento, estão liberados para uso o inibidor de C1 derivado de plasma e o icatibanto. O manejo correto desses pacientes na emergência evita cirurgias desnecessárias e, principalmente, desfechos fatais.

Published
2021

47. Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis

Author

Codo, Ana Campos, Davanzo, Gustavo Gastão, Monteiro, Lauar de Brito, de Souza, Gabriela Fabiano, Muraro, Stéfanie Primon, Virgilio-da-Silva, João Victor, Prodonoff, Juliana Silveira, Carregari, Victor Corasolla, de Biagi Junior, Carlos Alberto Oliveira, Crunfli, Fernanda, Jimenez Restrepo, Jeffersson Leandro, Vendramini, Pedro Henrique, Reis-de-Oliveira, Guilherme, Bispo dos Santos, Karina, Toledo-Teixeira, Daniel A., Parise, Pierina Lorencini, Martini, Matheus Cavalheiro, Marques, Rafael Elias, Carmo, Helison R., Borin, Alexandre, Coimbra, Laís Durço, Boldrini, Vinícius O., Brunetti, Natalia S., Vieira, Andre S., Mansour, Eli, Ulaf, Raisa G., Bernardes, Ana F., Nunes, Thyago A., Ribeiro, Luciana C., Palma, Andre C., Agrela, Marcus V., Moretti, Maria Luiza, Sposito, Andrei C., Pereira, Fabrício Bíscaro, Velloso, Licio Augusto, Vinolo, Marco Aurélio Ramirez, Damasio, André, Proença-Módena, José Luiz, Carvalho, Robson Francisco, Mori, Marcelo A., Martins-de-Souza, Daniel, Nakaya, Helder I., Farias, Alessandro S., and Moraes-Vieira, Pedro M.

Published
2020
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48. The Panorama of Primary Angioedema in the Brazilian Population

Author

Veronez, Camila Lopes, primary, Mendes, Agatha Ribeiro, additional, Leite, Caroliny Souza, additional, Gomes, Caio Perez, additional, Grumach, Anete Sevciovic, additional, Pesquero, João Bosco, additional, Cagini, Nathália, additional, Mansour, Eli, additional, da Silva, Jane, additional, Giavina-Bianchi, Pedro, additional, Teixeira, Ana Júlia, additional, Valle, Solange Rodrigues, additional, Goudouris, Ekaterini, additional, Serpa, Faradiba Sarquis, additional, Moyses, Therezinha R., additional, Campinhos, Fernanda Lugão, additional, Ensina, Luis Felipe, additional, Aranda, Carolina Sánchez, additional, Rizzo, Maria Cândida, additional, Campos, Régis A., additional, Gonçalves, Rozana Fátima, additional, Minafra, Fernanda Gontijo, additional, de Souza Bernardes, Marli, additional, Chong-Neto, Herberto José, additional, Filho, Nelson Rosário, additional, Guth, Carolina, additional, Toledo, Eliana, additional, Coelho Dias, Gabriela Andrade, additional, Piccirillo, Miguel Alberto, additional, Severo Ferreira, Janáira Fernandes, additional, Marcelino, Fernanda Casares, additional, da Rocha Rolins Neto, Pedro, additional, Franco, Jackeline Motta, additional, Pafume de Sá, Gustavo, additional, Garro, Laila Sabino, additional, Carolina da Matta Ain, Ana, additional, Velasco, Helena F., additional, Fernandes Carvalho, Ellaine Dóris, additional, Fernandes Carvalho de Andrade, Maria Denise, additional, Boll, Cristiane Alves, additional, Ferraroni, Natasha Rebouças, additional, Martins Pinto Swensson, Ana Carolina, additional, Vilela Rabelo, Leandro Augusto, additional, Pacheco de Figueiredo, Joanemile, additional, Figueredo, Raphael Coelho, additional, Mendes, Ronney Corrêa, additional, Sales, Valéria S.F., additional, Bacarini Leite, Luiz Fernando, additional, Beltran Moschione Castro, Ana Paula, additional, Ferreira Mascarenhas, Elke C., additional, Teixeira, Thais Bomfim, additional, Campos Teixeira, Camila A., additional, Pereira de Lira Marques, Adriana, additional, Pires Amaral Resende, Ludmilla Luzia, additional, Sandrin, Leda das Neves Almeida, additional, and Tavares, Clarissa Soares, additional

Published
2021
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49. Patients With Hereditary Angioedema Do Not Develop More Severe COVID-19 but SARS-CoV-2 Infection May Trigger Attacks: 66 Cases

Author

Olivares, Maria Margarita, primary, Zwiener, Ricardo Dario, additional, Panqueva, Lina Maria Leiva, additional, Verduzco, Francisco Alberto Contreras, additional, Mansour, Eli, additional, Rodriguez, Jairo Antonio, additional, Valle, Solange Oliveira Rodrigues, additional, Nieto, Sandra, additional, Silva, Jane Da, additional, Vazquez, Daniel O, additional, Llosa, Oscar Calderon, additional, Marcelino, Fernanda Casares, additional, Ratti-Sisa, Manuel, additional, Beas, Ileana María Madrigal, additional, Zaragoza-Urdaz, Rafael, additional, Toledo, Eliana Cristina, additional, Fili, Natalia Lorena, additional, Barrero, Olga M, additional, Aguirre, Juan Carlos Fernandez de Cordova, additional, Mora, Sergio Castro, additional, Sarrazola, Mauricio, additional, Raad, Rodolfo Jaller, additional, Cardenas, Edison Morales, additional, Josviak, Dario Oscar, additional, Fantini, Claudio, additional, Marocco, Monica, additional, Nievas, Elma I, additional, Serpa, Faradiba Sarquis, additional, Neto, Herberto Jose Chong, additional, Alonso, Maria Luiza Oliva, additional, Junior, Sergio Dortas, additional, Ulaf, Raisa Gusso, additional, Rosario, Nelson, additional, Barrero, Rodolfo Ramón Leyva, additional, and Grumach, Anete Sevciovic, additional

Published
2021
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50. Outcome of SARS-CoV-2 Infection in 121 Patients With Inborn Errors of Immunity: A Cross-sectional Study

Author

goudouris, ekaterini, primary, Pinto-Mariz, Fernanda, additional, Mendonça, Leonardo Oliveira, additional, Aranda, Carolina Sanchez, additional, Guimarães, Rafaela Rolla, additional, Kokron, Cristina, additional, Barros, Myrthes Toledo, additional, Anísio, Flávia, additional, Alonso, Maria Luiza Oliva, additional, Marcelino, Fernanda, additional, Valle, Solange Oliveira Rodrigues, additional, Junior, Sergio Dortas, additional, Barreto, Irma Douglas Paes, additional, Fernandes, Janáira, additional, Roxo, Pérsio, additional, Silva, Almerinda, additional, Campinho, Fernanda Lugão, additional, Bonfim, Carmem, additional, Loth, Gisele, additional, Fernandes, Juliana Folloni, additional, Garcia, Julia Lopes, additional, Capelo, Albertina, additional, Takano, Olga Akiko, additional, Nada, Maria Isabel Valdomir, additional, Toledo, Eliana, additional, Cunha, Luciana Araújo Oliveira, additional, Gesu, Regina Sumiko Watanabe Di, additional, Schidlowsk, Laire, additional, Fillipo, Priscila, additional, Bichuetti, Danielli, additional, Soldateli, Gustavo, additional, Ferraroni, Natasha Rebouças, additional, Dantas, Ellen, additional, Pestana, Simone, additional, Mansour, Eli, additional, Ulaf, Raisa Gusso, additional, Prando, Carolina, additional, Condino-Neto, Antonio, additional, and Grumach, Anete Sevciovic, additional

Published
2021
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