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1. Clinical significance of CD56 expression in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline-based regimens

Author

Montesinos, Pau, Rayón, Chelo, Vellenga, Edo, Brunet, Salut, González, José, González, Marcos, Holowiecka, Aleksandra, Esteve, Jordi, Bergua, Juan, González, José D., Rivas, Concha, Tormo, Mar, Rubio, Vicente, Bueno, Javier, Manso, Félix, Milone, Gustavo, de la Serna, Javier, Pérez, Inmaculada, Pérez-Encinas, Manuel, Krsnik, Isabel, Ribera, Josep M., Escoda, Lourdes, Lowenberg, Bob, and Sanz, Miguel A.

Published
2011
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2. Risk-adapted treatment of acute promyelocytic leukemia based on all-trans retinoic acid and anthracycline with addition of cytarabine in consolidation therapy for high-risk patients: further improvements in treatment outcome

Author

Sanz, Miguel A., Montesinos, Pau, Rayón, Chelo, Holowiecka, Alexandra, de la Serna, Javier, Milone, Gustavo, de Lisa, Elena, Brunet, Salut, Rubio, Vicente, Ribera, José M., Rivas, Concha, Krsnik, Isabel, Bergua, Juan, González, José, Díaz-Mediavilla, Joaquín, Rojas, Rafael, Manso, Félix, Ossenkoppele, Gert, González, José D., and Lowenberg, Bob

Published
2010
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3. Clinical significance of complex karyotype at diagnosis in pediatric and adult patients with de novo acute promyelocytic leukemia treated with ATRA and chemotherapy

Author

Labrador, Jorge, Luno, Elisa, Vellenga, Edo, Brunet, Salut, Gonzalez-Campose, Jose, Chillon, Maria C., Holowiecka, Aleksandra, Esteve, Jordi, Bergua, Juan, Gonzalez-Sanmiguel, Jose D., Gil, Cristina, Tormo, M., Salamero, Olga, Manso, Felix, Fernandez, Isolda, de laSerna, Javier, Moreno, Maria-Jose, Perez-Encinas, M., Krsnik, Isabel, Ribera, Josep-Maria, Cervera, Jose, Calasanz, Maria J., Boluda, Blanca, Sobas, Marta, Lowenberg, Bob, Sanz, Miguel A., Montesinos, Pau, Palmer, L., Fernandez, Ciarlo, S., Bezares, F., Rojas, F., Longoni, H., Gelemur, M., Fazio, P., Canepa, C., Saba, S., Balladares, G., Negri, P., Giunta, M., Milone, J., Prates, M., Lafalse, D., Sossa, C., Jaramillo, F., Mayer, J., Ramos, F., Martinez, J., de Groot, M. R., Schouten, H. C., Hematology, Guided Treatment in Optimal Selected Cancer Patients (GUTS), Stem Cell Aging Leukemia and Lymphoma (SALL), Interne Geneeskunde, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, and MUMC+: MA Hematologie (9)

Subjects
Male, Cancer Research, complex karyotype, ANTHRACYCLINE MONOCHEMOTHERAPY, medicine.medical_treatment, Abnormal Karyotype, chemotherapy, Gastroenterology, Leukocyte Count, 0302 clinical medicine, Leukemia, Promyelocytic, Acute, Recurrence, Acute promyelocytic leukemia, Antineoplastic Combined Chemotherapy Protocols, PROGNOSTIC-SIGNIFICANCE, Cumulative incidence, ATRA, Child, In Situ Hybridization, Fluorescence, Aged, 80 and over, relapse, PETHEMA, Incidence (epidemiology), ADDITIONAL CHROMOSOME-ABNORMALITIES, Age Factors, Hematology, Middle Aged, Prognosis, ARSENIC TRIOXIDE, FLT3 MUTATIONS, Leukemia, Treatment Outcome, Oncology, Child, Preschool, 030220 oncology & carcinogenesis, Cytogenetic Analysis, Female, Adult, medicine.medical_specialty, CYTOGENETIC CHANGES, Adolescent, Young Adult, 03 medical and health sciences, Internal medicine, Statistical significance, Complex Karyotype, medicine, Humans, Clinical significance, Aged, CONSOLIDATION THERAPY, Chromosome Aberrations, Chemotherapy, business.industry, medicine.disease, RISK-ADAPTED TREATMENT, TRANS-RETINOIC ACID, ATRA, Acute promyelocytic leukemia, chemotherapy, complex karyotype, prognostic, relapse, business, prognostic, 030215 immunology
Abstract

Although additional cytogenetic abnormalities (ACA) do not affect the prognosis of patients with t(15;17) acute promyelocytic leukemia (APL), the role of a complex karyotype (CK) is yet to be clarified. We aimed to investigate the relationship of CK with relapse incidence in 1559 consecutive APL patients enrolled in three consecutive trials. Treatment consisted of AIDA induction followed by risk-adapted consolidation. A CK (CK) was defined as the presence of ≥2 ACA, and a very CK (CK+) as ≥3 ACA. Eighty-nine patients (8%) had a CK, of whom 41 (4%) had CK+. The 5-year cumulative incidence of relapse (CIR) in patients with CK was 18%, and 12% in those with

Published
2019

4. An analysis of the impact of CD56 expression in de novo acute promyelocytic leukemia patients treated with upfront all-trans retinoic acid and anthracycline-based regimens

Author

Sobas, Marta, Montesinos, Pau, Boluda, Blanca, Bernal, Teresa, Vellenga, Edo, Nomdedeu, Josep, Gonzalez-Campos, Jose, Chillon, Maria, Holowiecka, Aleksandra, Esteve, Jordi, Bergua, Juan, David Gonzalez-Sanmiguel, Jose, Gil-Cortes, Cristina, Tormo, M., Salamero, Olga, Manso, Felix, Fernandez, Isolda, de la Serna, Javier, Moreno, Maria-Jose, Perez-Encinas, Manuel, Krsnik, Isabel, Ribera, Josep-Maria, Escoda, Lourdes, Lowenberg, Bob, Angel Sanz, Miguel, Beltran de Heredia, J. M., Hernandez, J. M., Arias, J., Ramos, F., Roman, A., de la Serna, J., Negri, S., Rayon, C., Esteve, J., Fernandez-Calvo, F. J., Diaz-Mediavilla, J., Gil, C., Olave, M., Amutio, E., Pedro, C., Gorosquieta, A., Viguria, M., Zudaire, M., Molero, T., Sayas, M. J., Guardia, R., Martinez, J., de Groot, M. R., Schouten, H. C., Hematology, Radiotherapy, Erasmus MC other, Guided Treatment in Optimal Selected Cancer Patients (GUTS), Stem Cell Aging Leukemia and Lymphoma (SALL), Interne Geneeskunde, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, and MUMC+: MA Hematologie (9)

Subjects
Male, Cancer Research, medicine.medical_treatment, Retinoic acid, CD34, Gene Expression, Kaplan-Meier Estimate, chemotherapy, Gastroenterology, chemistry.chemical_compound, 0302 clinical medicine, PROGNOSTIC-FACTORS, Leukemia, Promyelocytic, Acute, Recurrence, Acute promyelocytic leukemia, Antineoplastic Combined Chemotherapy Protocols, FAILURE, Anthracyclines, Cumulative incidence, ATRA, Child, CONSOLIDATION, relapse, RISK, Hematology, Middle Aged, Prognosis, CD56 Antigen, Leukemia, Treatment Outcome, Oncology, Child, Preschool, 030220 oncology & carcinogenesis, Female, CD56, medicine.medical_specialty, Adolescent, Anthracycline, Tretinoin, Young Adult, 03 medical and health sciences, ADULT, Internal medicine, medicine, Humans, INDICATOR, Aged, Chemotherapy, business.industry, De novo acute, medicine.disease, chemistry, business, prognostic, 030215 immunology
Abstract

Out of 956, there were 95 (10%) CD56+ APL patients treated with PETHEMA ATRA and chemotherapy. CD56+ expression was associated with high WBC, BCR3 isoform, and co-expression of CD2, CD34, CD7, HLA-DR, CD15, and CD117 antigens. CD56+ vs CD56- APL presented higher induction death rate (16% vs 8%, p = .02) and 5-years cumulative incidence of relapse (33% versus 10%, p = .006), irrespectively of the Sanz score (low-risk 47% versus 5%, p

Published
2019
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5. Characteristics and outcome of adult patients with acute promyelocytic leukemia and increased body mass index treated with the PETHEMA Protocols.

Author

Sobas, Marta, Rodriguez‐Veiga, Rebeca, Vellenga, Edo, Paluszewska, Monika, De la Serna, Javier, García‐Álvarez, Flor, Gil, Cristina, Brunet, Salut, Bergua, Juan, González‐Campos, Jose, Ribera, José María, Tormo, Mar, González, Marcos, Fernández, Isolda, Benavente, Celina, González‐Sanmiguel, Jose D., Esteve, Jordi, Pérez‐Encinas, Manuel, Salamero, Olga, and Manso, Felix

Subjects
ACUTE promyelocytic leukemia, BODY mass index, OVERWEIGHT persons
Abstract

Objective: The obesity/overweight may have an influence on APL outcomes. Methods: This is the biggest multicentre analysis on 1320 APL patients treated with AIDA‐induction and risk‐adapted consolidation between 1996 and 2012. Patients body mass index (BMI) was classified as underweight (<18.5 kg/m2), normal (18.5‐25 kg/m2), overweight (25‐29.9 kg/m2), and obese (≥30 kg/m2) according to the World Health Organization (WHO) criteria. Results and conclusions: Relationship between male gender, older age, and other known laboratory abnormalities in overweight/obese patients was significant. The induction mortality rate was significantly higher in APL with BMI ≥25 vs BMI <25 (10% vs 6%; P =.04). APL patients with BMI ≥25 had a trend to lower OS (74% vs 80%; P =.06). However, in the multivariate analysis, BMI did not retain the independent predictive value (P =.46). There was no higher incidence of differentiation syndrome with BMI ≥25, but there was a trend in obese. There was no difference in relapse rate according to the BMI. In summary, overweight/obesity does not represent an independent risk factor for APL outcomes. The influence of obesity in APL patients treated with chemotherapy‐free regimens remains to be established. [ABSTRACT FROM AUTHOR]

Published
2020
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6. Clinical significance of complex karyotype at diagnosis in pediatric and adult patients with de novo acute promyelocytic leukemia treated with ATRA and chemotherapy

Author

Labrador, Jorge, primary, Luño, Elisa, additional, Vellenga, Edo, additional, Brunet, Salut, additional, González-Campos, José, additional, Chillón, Maria C., additional, Holowiecka, Aleksandra, additional, Esteve, Jordi, additional, Bergua, Juan, additional, González-Sanmiguel, José D, additional, Gil, Cristina, additional, Tormo, Mar, additional, Salamero, Olga, additional, Manso, Felix, additional, Fernández, Isolda, additional, de laSerna, Javier, additional, Moreno, María-José, additional, Pérez-Encinas, Manuel, additional, Krsnik, Isabel, additional, Ribera, Josep-Maria, additional, Cervera, Jose, additional, Calasanz, María J., additional, Boluda, Blanca, additional, Sobas, Marta, additional, Lowenberg, Bob, additional, Sanz, Miguel A., additional, and Montesinos, Pau, additional

Published
2018
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8. Long-Term Outcome Of 151 Patients With Relapsed APL Receiving Second-Line With Chemotherapy Or Arsenic Trioxide-Based Regimens

Author

Montesinos, Pau, Martínez-Cuadrón, David, Rivas, Concha, Brunet, Salut, González-San Miguel, José David, Rubio, Vicente, Pérez, Cristina, Manso, Félix, Sánchez-Godoy, Pedro, Escoda, Lourdes, Amutio, Elena, Zijlmans, Mark, Tormo, Mar, González, Marcos, Rayón, Chelo, Sayas, María José, Ribera, Josep-Maria, Deben, Guillermo, Hernández-Martín, José, Esteve, Jordi, Vellenga, Edo, and Sanz, Miguel

Published
2013
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