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3. The Ramazzini Institute 13-week pilot study glyphosate-based herbicides administered at human-equivalent dose to Sprague Dawley rats: effects on development and endocrine system

Author

Manservisi, Fabiana, Lesseur, Corina, Panzacchi, Simona, Mandrioli, Daniele, Falcioni, Laura, Bua, Luciano, Manservigi, Marco, Spinaci, Marcella, Galeati, Giovanna, Mantovani, Alberto, Lorenzetti, Stefano, Miglio, Rossella, Andrade, Anderson Martino, Kristensen, David Møbjerg, Perry, Melissa J., Swan, Shanna H., Chen, Jia, and Belpoggi, Fiorella

Published
2019
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10. The Ramazzini Institute 13-week pilot study glyphosate-based herbicides administered at human-equivalent dose to Sprague Dawley rats:effects on development and endocrine system

Author

Manservisi, Fabiana, Lesseur, Corina, Panzacchi, Simona, Mandrioli, Daniele, Falcioni, Laura, Bua, Luciano, Manservigi, Marco, Spinaci, Marcella, Galeati, Giovanna, Mantovani, Alberto, Lorenzetti, Stefano, Miglio, Rossella, Andrade, Anderson Martino, Kristensen, David Mobjerg, Perry, Melissa J., Swan, Shanna H., Chen, Jia, Belpoggi, Fiorella, Manservisi, Fabiana, Lesseur, Corina, Panzacchi, Simona, Mandrioli, Daniele, Falcioni, Laura, Bua, Luciano, Manservigi, Marco, Spinaci, Marcella, Galeati, Giovanna, Mantovani, Alberto, Lorenzetti, Stefano, Miglio, Rossella, Andrade, Anderson Martino, Kristensen, David Mobjerg, Perry, Melissa J., Swan, Shanna H., Chen, Jia, and Belpoggi, Fiorella

Abstract

Background Glyphosate-based herbicides (GBHs) are broad-spectrum herbicides that act on the shikimate pathway in bacteria, fungi, and plants. The possible effects of GBHs on human health are the subject of an intense public debate for both its potential carcinogenic and non-carcinogenic effects, including potential effects on the endocrine system The present pilot study examine whether exposure to GBHs at the dose of glyphosate considered to be “safe” (the US Acceptable Daily Intake - ADI - of 1.75 mg/kg bw/day), starting from in utero life, affect the development and endocrine system across different life stages in Sprague Dawley (SD) rats. Methods Glyphosate alone and Roundup Bioflow, a commercial brand of GBHs, were administered in drinking water at 1.75 mg/kg bw/day to F0 dams starting from the gestational day (GD) 6 (in utero) up to postnatal day (PND) 120. After weaning, offspring were randomly distributed in two cohorts: 8 M + 8F/group animals belonging to the 6-week cohort were sacrificed after puberty at PND 73 ± 2; 10 M + 10F/group animals belonging to the 13-week cohort were sacrificed at adulthood at PND 125 ± 2. Effects of glyphosate or Roundup exposure were assessed on developmental landmarks and sexual characteristics of pups. Results In pups, anogenital distance (AGD) at PND 4 was statistically significantly increased both in Roundup-treated males and females and in glyphosate-treated males. Age at first estrous (FE) was significantly delayed in the Roundup-exposed group and serum testosterone concentration significantly increased in Roundup-treated female offspring from the 13-week cohort compared to control animals. A statistically significant increase in plasma TSH concentration was observed in glyphosate-treated males compared with control animals as well as a statistically significant decrease in DHT and increase in BDNF in Roundup-treated males. Hormonal status imbalances were more pronounced in Roundup-treated rat

Published
2019

11. Erratum: 'An Integrated Experimental Design for the Assessment of Multiple Toxicological End Points in Rat Bioassays'

Author

Manservisi, Fabiana, Marquillas, Clara Babot, Buscaroli, Annalisa, Huff, James, Lauriola, Michelina, Mandrioli, Daniele, Manservigi, Marco, Panzacchi, Simona, Silbergeld, Ellen K., and Belpoggi, Fiorella

Subjects
Environmental issues, Health
Abstract

Environ Health Perspect 125(3):289-295, (2016), http://dx.doi.org/10.1289/EHP419 Owing to an oversight, the authors did not acknowledge contributions to our integrated model paper (Manservisi et al. 2017) by Professors Susan L. Teitelbaum [...]

Published
2017
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13. Synergism between sinusoidal-50 Hz magnetic field and formaldehyde in triggering carcinogenic effects in male Sprague-Dawley rats

Author

Soffritti, Morando, primary, Tibaldi, Eva, additional, Padovani, Michela, additional, Hoel, David G., additional, Giuliani, Livio, additional, Bua, Luciano, additional, Lauriola, Michelina, additional, Falcioni, Laura, additional, Manservigi, Marco, additional, Manservisi, Fabiana, additional, and Belpoggi, Fiorella, additional

Published
2016
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14. Life-span exposure to sinusoidal-50 Hz magnetic field and acute low-dose γ radiation induce carcinogenic effects in Sprague-Dawley rats

Author

Soffritti, Morando, primary, Tibaldi, Eva, additional, Padovani, Michela, additional, Hoel, David G., additional, Giuliani, Livio, additional, Bua, Luciano, additional, Lauriola, Michelina, additional, Falcioni, Laura, additional, Manservigi, Marco, additional, Manservisi, Fabiana, additional, Panzacchi, Simona, additional, and Belpoggi, Fiorella, additional

Published
2016
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17. Life-span carcinogenicity studies on Sprague-Dawley rats exposed to γ-radiation: Design of the project and report on the tumor occurrence after post-natal radiation exposure (6 weeks of age) delivered in a single acute exposure

Author

Soffritti, Morando, primary, Tibaldi, Eva, additional, Bua, Luciano, additional, Padovani, Michela, additional, Falcioni, Laura, additional, Lauriola, Michelina, additional, Manservigi, Marco, additional, Manservisi, Fabiana, additional, and Belpoggi, Fiorella, additional

Published
2014
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19. Additional file 2: of The Ramazzini Institute 13-week pilot study glyphosate-based herbicides administered at human-equivalent dose to Sprague Dawley rats: effects on development and endocrine system

Author

Manservisi, Fabiana, Lesseur, Corina, Panzacchi, Simona, Mandrioli, Daniele, Falcioni, Laura, Bua, Luciano, Manservigi, Marco, Spinaci, Marcella, Galeati, Giovanna, Mantovani, Alberto, Lorenzetti, Stefano, Miglio, Rossella, Andrade, Anderson, Kristensen, David, Perry, Melissa, Swan, Shanna, Chen, Jia, and Belpoggi, Fiorella

Subjects
3. Good health
Abstract

Figure S2. First estrous box plot (A) and dot plot (B). (DOCX 33 kb)

20. Additional file 5: of The Ramazzini Institute 13-week pilot study glyphosate-based herbicides administered at human-equivalent dose to Sprague Dawley rats: effects on development and endocrine system

Author

Manservisi, Fabiana, Lesseur, Corina, Panzacchi, Simona, Mandrioli, Daniele, Falcioni, Laura, Bua, Luciano, Manservigi, Marco, Spinaci, Marcella, Galeati, Giovanna, Mantovani, Alberto, Lorenzetti, Stefano, Miglio, Rossella, Andrade, Anderson, Kristensen, David, Perry, Melissa, Swan, Shanna, Chen, Jia, and Belpoggi, Fiorella

Subjects
3. Good health
Abstract

Figure S5. Effects of glyphosate or Roundup Bioflow exposure on hormones in females (meanâ Âąâ SEM); coefficient of variation in square brackets. (DOCX 23 kb)

21. Additional file 2: of The Ramazzini Institute 13-week pilot study glyphosate-based herbicides administered at human-equivalent dose to Sprague Dawley rats: effects on development and endocrine system

Author

Manservisi, Fabiana, Lesseur, Corina, Panzacchi, Simona, Mandrioli, Daniele, Falcioni, Laura, Bua, Luciano, Manservigi, Marco, Spinaci, Marcella, Galeati, Giovanna, Mantovani, Alberto, Lorenzetti, Stefano, Miglio, Rossella, Andrade, Anderson, Kristensen, David, Perry, Melissa, Swan, Shanna, Chen, Jia, and Belpoggi, Fiorella

Subjects
3. Good health
Abstract

Figure S2. First estrous box plot (A) and dot plot (B). (DOCX 33 kb)

22. Additional file 3: of The Ramazzini Institute 13-week pilot study glyphosate-based herbicides administered at human-equivalent dose to Sprague Dawley rats: effects on development and endocrine system

Author

Manservisi, Fabiana, Lesseur, Corina, Panzacchi, Simona, Mandrioli, Daniele, Falcioni, Laura, Bua, Luciano, Manservigi, Marco, Spinaci, Marcella, Galeati, Giovanna, Mantovani, Alberto, Lorenzetti, Stefano, Miglio, Rossella, Andrade, Anderson, Kristensen, David, Perry, Melissa, Swan, Shanna, Chen, Jia, and Belpoggi, Fiorella

Subjects
3. Good health
Abstract

Figure S3. Male and female DHT box plot (A) and dot blot (B). (DOCX 86 kb)

23. Additional file 1: of The Ramazzini Institute 13-week pilot study glyphosate-based herbicides administered at human-equivalent dose to Sprague Dawley rats: effects on development and endocrine system

Author

Manservisi, Fabiana, Lesseur, Corina, Panzacchi, Simona, Mandrioli, Daniele, Falcioni, Laura, Bua, Luciano, Manservigi, Marco, Spinaci, Marcella, Galeati, Giovanna, Mantovani, Alberto, Lorenzetti, Stefano, Miglio, Rossella, Andrade, Anderson, Kristensen, David, Perry, Melissa, Swan, Shanna, Chen, Jia, and Belpoggi, Fiorella

Subjects
3. Good health
Abstract

Figure S1. AGD index and AGD (Mean per litter) box plot (A) and dot plot (B). (DOCX 83 kb)

24. Additional file 1: of The Ramazzini Institute 13-week pilot study glyphosate-based herbicides administered at human-equivalent dose to Sprague Dawley rats: effects on development and endocrine system

Author

Manservisi, Fabiana, Lesseur, Corina, Panzacchi, Simona, Mandrioli, Daniele, Falcioni, Laura, Bua, Luciano, Manservigi, Marco, Spinaci, Marcella, Galeati, Giovanna, Mantovani, Alberto, Lorenzetti, Stefano, Miglio, Rossella, Andrade, Anderson, Kristensen, David, Perry, Melissa, Swan, Shanna, Chen, Jia, and Belpoggi, Fiorella

Subjects
3. Good health
Abstract

Figure S1. AGD index and AGD (Mean per litter) box plot (A) and dot plot (B). (DOCX 83 kb)

25. Additional file 3: of The Ramazzini Institute 13-week pilot study glyphosate-based herbicides administered at human-equivalent dose to Sprague Dawley rats: effects on development and endocrine system

Author

Manservisi, Fabiana, Lesseur, Corina, Panzacchi, Simona, Mandrioli, Daniele, Falcioni, Laura, Bua, Luciano, Manservigi, Marco, Spinaci, Marcella, Galeati, Giovanna, Mantovani, Alberto, Lorenzetti, Stefano, Miglio, Rossella, Andrade, Anderson, Kristensen, David, Perry, Melissa, Swan, Shanna, Chen, Jia, and Belpoggi, Fiorella

Subjects
3. Good health
Abstract

Figure S3. Male and female DHT box plot (A) and dot blot (B). (DOCX 86 kb)

26. Additional file 4: of The Ramazzini Institute 13-week pilot study glyphosate-based herbicides administered at human-equivalent dose to Sprague Dawley rats: effects on development and endocrine system

Author

Manservisi, Fabiana, Lesseur, Corina, Panzacchi, Simona, Mandrioli, Daniele, Falcioni, Laura, Bua, Luciano, Manservigi, Marco, Spinaci, Marcella, Galeati, Giovanna, Mantovani, Alberto, Lorenzetti, Stefano, Miglio, Rossella, Andrade, Anderson, Kristensen, David, Perry, Melissa, Swan, Shanna, Chen, Jia, and Belpoggi, Fiorella

Subjects
3. Good health
Abstract

Figure S4. Effects of glyphosate or Roundup Bioflow exposure on hormones in males (meanâ Âąâ SEM); coefficient of variation in square brackets. (DOCX 23 kb)

27. Additional file 5: of The Ramazzini Institute 13-week pilot study glyphosate-based herbicides administered at human-equivalent dose to Sprague Dawley rats: effects on development and endocrine system

Author

Manservisi, Fabiana, Lesseur, Corina, Panzacchi, Simona, Mandrioli, Daniele, Falcioni, Laura, Bua, Luciano, Manservigi, Marco, Spinaci, Marcella, Galeati, Giovanna, Mantovani, Alberto, Lorenzetti, Stefano, Miglio, Rossella, Andrade, Anderson, Kristensen, David, Perry, Melissa, Swan, Shanna, Chen, Jia, and Belpoggi, Fiorella

Subjects
3. Good health
Abstract

Figure S5. Effects of glyphosate or Roundup Bioflow exposure on hormones in females (meanâ Âąâ SEM); coefficient of variation in square brackets. (DOCX 23 kb)

28. Additional file 4: of The Ramazzini Institute 13-week pilot study glyphosate-based herbicides administered at human-equivalent dose to Sprague Dawley rats: effects on development and endocrine system

Author

Manservisi, Fabiana, Lesseur, Corina, Panzacchi, Simona, Mandrioli, Daniele, Falcioni, Laura, Bua, Luciano, Manservigi, Marco, Spinaci, Marcella, Galeati, Giovanna, Mantovani, Alberto, Lorenzetti, Stefano, Miglio, Rossella, Andrade, Anderson, Kristensen, David, Perry, Melissa, Swan, Shanna, Chen, Jia, and Belpoggi, Fiorella

Subjects
3. Good health
Abstract

Figure S4. Effects of glyphosate or Roundup Bioflow exposure on hormones in males (meanâ Âąâ SEM); coefficient of variation in square brackets. (DOCX 23 kb)

29. The Ramazzini Institute 13-week pilot study glyphosate-based herbicides administered at human-equivalent dose to Sprague Dawley rats: Effects on development and endocrine system

Author

Marco Manservigi, Fiorella Belpoggi, Alberto Mantovani, Laura Falcioni, Shanna H. Swan, Stefano Lorenzetti, Giovanna Galeati, David Møbjerg Kristensen, Anderson J.M. Andrade, Marcella Spinaci, Corina Lesseur, Luciano Bua, Fabiana Manservisi, Melissa J. Perry, Simona Panzacchi, Rossella Miglio, Daniele Mandrioli, Jia Chen, Manservisi, Fabiana, Lesseur, Corina, Panzacchi, Simona, Mandrioli, Daniele, Falcioni, Laura, Bua, Luciano, Manservigi, Marco, Spinaci, Marcella, Galeati, Giovanna, Mantovani, Alberto, Lorenzetti, Stefano, Miglio, Rossella, Andrade, Anderson Martino, Kristensen, David Møbjerg, Perry, Melissa J., Swan, Shanna H., Chen, Jia, and Belpoggi, Fiorella

Subjects
Male, Offspring, Health, Toxicology and Mutagenesis, Glycine, Anal Canal, Thyrotropin, Physiology, Endocrine System, Estrous Cycle, Pilot Projects, Genitalia, Male, 010501 environmental sciences, 01 natural sciences, Rats, Sprague-Dawley, lcsh:RC963-969, 03 medical and health sciences, Pregnancy, Animals, Humans, Weaning, Medicine, Endocrine system, Testosterone, Sexual Maturation, Maternal-Fetal Exchange, 030304 developmental biology, 0105 earth and related environmental sciences, Estrous cycle, 0303 health sciences, Herbicides, business.industry, lcsh:Public aspects of medicine, Research, Toxicity Tests, Subchronic, Anogenital distance, Public Health, Environmental and Occupational Health, lcsh:RA1-1270, Genitalia, Female, 3. Good health, In utero, lcsh:Industrial medicine. Industrial hygiene, Gestation, Female, business, Hormone
Abstract

Background Glyphosate-based herbicides (GBHs) are broad-spectrum herbicides that act on the shikimate pathway in bacteria, fungi, and plants. The possible effects of GBHs on human health are the subject of an intense public debate for both its potential carcinogenic and non-carcinogenic effects, including potential effects on the endocrine system The present pilot study examine whether exposure to GBHs at the dose of glyphosate considered to be “safe” (the US Acceptable Daily Intake - ADI - of 1.75 mg/kg bw/day), starting from in utero life, affect the development and endocrine system across different life stages in Sprague Dawley (SD) rats. Methods Glyphosate alone and Roundup Bioflow, a commercial brand of GBHs, were administered in drinking water at 1.75 mg/kg bw/day to F0 dams starting from the gestational day (GD) 6 (in utero) up to postnatal day (PND) 120. After weaning, offspring were randomly distributed in two cohorts: 8 M + 8F/group animals belonging to the 6-week cohort were sacrificed after puberty at PND 73 ± 2; 10 M + 10F/group animals belonging to the 13-week cohort were sacrificed at adulthood at PND 125 ± 2. Effects of glyphosate or Roundup exposure were assessed on developmental landmarks and sexual characteristics of pups. Results In pups, anogenital distance (AGD) at PND 4 was statistically significantly increased both in Roundup-treated males and females and in glyphosate-treated males. Age at first estrous (FE) was significantly delayed in the Roundup-exposed group and serum testosterone concentration significantly increased in Roundup-treated female offspring from the 13-week cohort compared to control animals. A statistically significant increase in plasma TSH concentration was observed in glyphosate-treated males compared with control animals as well as a statistically significant decrease in DHT and increase in BDNF in Roundup-treated males. Hormonal status imbalances were more pronounced in Roundup-treated rats after prolonged exposure. Conclusions The present pilot study demonstrate that GBHs exposure, from prenatal period to adulthood, induced endocrine effects and altered reproductive developmental parameters in male and female SD rats. In particular, it was associated with androgen-like effects, including a statistically significant increase of AGDs in both males and females, delay of FE and increased testosterone in female. Electronic supplementary material The online version of this article (10.1186/s12940-019-0453-y) contains supplementary material, which is available to authorized users.

Published
2019
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30. Stem cells and nervous tissue repair: from in vitro to in vivo.

Author

Calzà L, Fernandez M, Giuliani A, Pirondi S, D'Intino G, Manservigi M, De Sordi N, and Giardino L

Subjects
2',3'-Cyclic-Nucleotide Phosphodiesterases metabolism, Animals, Bisbenzimidazole metabolism, Blotting, Western methods, Brain cytology, Brain Diseases complications, Cell Differentiation, Cell Division physiology, Cells, Cultured, Cerebral Ventricle Neoplasms metabolism, Encephalomyelitis, Autoimmune, Experimental metabolism, Epidermal Growth Factor administration & dosage, Epidermal Growth Factor metabolism, Fluorescent Antibody Technique methods, Glial Fibrillary Acidic Protein metabolism, In Vitro Techniques, Injections, Intraventricular mortality, Intermediate Filament Proteins metabolism, Male, Microscopy, Confocal methods, Neoplasms metabolism, Nerve Degeneration etiology, Nerve Growth Factor metabolism, Nestin, Neural Cell Adhesion Molecule L1 metabolism, Neuroglia metabolism, Neurons metabolism, Rats, Sialic Acids metabolism, Stem Cell Transplantation methods, Brain Diseases therapy, Nerve Degeneration therapy, Nerve Tissue Proteins, Stem Cells physiology, Wound Healing
Abstract

Recent development in stem cell biology has indicated a new possible approach for the treatment of neurological diseases. However, in spite of tremendous hope generated, we are still on the way to understand if the use of stem cells to repair mature brain and spinal cord is a reliable possibility. In particular, we know very little on the in situ regulation of adult neural stem, and this also negatively impact on cell transplant possibilities. In this chapter we will discuss issues concerning the role and function of stem cells in neurological diseases, with regard to the impact of features of degenerating neurons and glial cells on in situ stem cells. Stem cell location and biology in the adult brain, brain host reaction to transplantation, neural stem cell reaction to experimental injuries and possibilities for exogenous regulation are the main topics discussed.

Published
2004
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