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2. Retrospective evaluation of voriconazole treatment in psittacines: 14 cases (2012-2023).

Author

Hinkle, Daria and Mans, Christoph

Subjects
*VORICONAZOLE, *MYCOSES, *SYMPTOMS, *RESPIRATORY infections, *DIAGNOSTIC imaging
Abstract

OBJECTIVE To retrospectively evaluate the clinical use of voriconazole in psittacine patients for the treatment of suspected respiratory fungal infections. ANIMALS 14 client-owned psittacine birds. METHODS Medical records were searched from 2012 to 2023 for voriconazole use in psittacines. Species, age, clinical signs, physical examination findings, CT reports, bloodwork results, treatment, and outcome were obtained from the records or client follow-up. RESULTS African grey parrots were the most prevalent species (8/14). Dyspnea (9/14) and abnormal respiratory auscultation (11/14) were the most common examination abnormalities. An initial CT was performed in all cases, and pneumonia (10/14) and air sac disease (9/14) were the most common findings, with 8 cases having both pulmonary and air sac disease. Voriconazole doses ranged from 10 to 21 mg/kg (median, 16 mg/kg), with most cases prescribed as every-12-hour frequency (12/14). Three of 14 (21%) cases died or were euthanized within 24 days of diagnosis. One case was euthanized at 311 days, and 6 cases were lost to follow-up. Four of 14 (29%) cases lived > 12 months from diagnosis. Two of these cases cleared clinical infection after receiving voriconazole at 17 to 18 mg/kg (q 12 h). No adverse effects attributable to voriconazole were reported. CLINICAL RELEVANCE Voriconazole can be safely used for the treatment of suspected fungal respiratory infection in psittacines. However, the prognosis for resolution is guarded, and prolonged treatment and repeated diagnostic imaging are necessary in many cases. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Diagnosis and outcome of odontogenic abscesses in client-owned rabbits (Oryctolagus cuniculus): 72 cases (2011-2022).

Author

Levy, Ivana and Mans, Christoph

Subjects
*EUROPEAN rabbit, *MEDICAL record databases, *RABBITS, *ABSCESSES, *DIAGNOSIS
Abstract

OBJECTIVE To characterize the epidemiologic features of rabbits with odontogenic abscesses. ANIMALS 72 client-owned rabbits. METHODS The medical record database of a veterinary teaching hospital was searched to identify rabbits with odontogenic abscesses characterized by a palpable facial mass and confirmed via CT scan. Data reviewed included age, breed, presenting complaint, abscess location, bacterial culture results, treatment, and outcome. RESULTS Lop-eared rabbits were the most common breeds affected (20/72 [28%]), and mini lop rabbits were significantly overrepresented. The mandibular quadrants were more frequently affected (65/92 [71%]), and osteomyelitis was a common comorbidity on CT (53/72 [74%]). The most common aerobic and anaerobic isolates were Streptococcus spp ( 17/40 [43%]) and Fusobacterium splp ( 10/22 [45%]), respectively. Systemic antibiotic therapy alone was performed in 35 of 62 (56%) treated cases, with documented resolution in 25%. Abscess packing with antibiotic-soaked gauze in conjunction with systemic antibiotic therapy was performed in 20 of 62 (32%) treated cases. Resolution of the odontogenic abscesses with this treatment protocol was documented in 17 of 20 (85%) cases. The number of packing procedures used to obtain resolution of infection was 4 (IQR, 3 to 5). CLINICAL RELEVANCE A combination of the abscess-packing technique, which avoids extensive surgery and extraction of the involved elodont teeth, with systemic antibiotic therapy can be an effective treatment option for rabbits with palpable odontogenic abscesses and can result in a high cure rate comparable to more invasive surgical treatments. Antibiotic treatment alone is not recommended, as it has a low chance of abscess resolution. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Dedication

Author

Quesenberry, Katherine E., primary, Orcutt, Connie J., additional, Mans, Christoph, additional, and Carpenter, James W., additional

Published
2021
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14. Contributors

Author

Benato, Livia, primary, Bennett, R. Avery, additional, Brandão, LMV, João, additional, Capello, Vittorio, additional, Carpenter, James W., additional, Casale, Sue, additional, d’Ovidio, Dario, additional, de Matos, Ricardo, additional, Di Girolamo, Nicola, additional, Divers, Stephen J., additional, Donnelly, Thomas M., additional, Doss, Grayson A., additional, Eshar, David, additional, Fischetti, Anthony J., additional, Fisher, Peter G., additional, Frohlich, Jennifer, additional, Gardhouse, Sara M., additional, Gladden, Jay N., additional, Graham, Jennifer, additional, Hawkins, Michelle G., additional, Hoefer, Heidi L., additional, Huynh, Minh, additional, Jekl, Vladimir, additional, Johnson-Delaney, Cathy, additional, Kapatkin, Amy S., additional, Künzel, Frank, additional, Legendre, Loic Frederic, additional, Lennox, Angela M., additional, Lord, Brigitte, additional, Malakoff, Rebecca L., additional, Mancinelli, Elisabetta, additional, Mans, Christoph, additional, Mayer, Joerg, additional, Mitchell, Mark A., additional, Miwa, Yasutsugu, additional, Morrisey, James K., additional, Oglesbee, Barbara L., additional, Orcutt, Connie J., additional, Pascoe, Peter J., additional, Paterson, Susan, additional, Perpinan, David, additional, Piazza, Stéphanie, additional, Pignon, Charly, additional, Pilny, Anthony A., additional, Powers, Lauren V., additional, Quesenberry, Katherine E., additional, Rylander, Helena, additional, Sanchez-Migallon Guzman, David, additional, Santoro, Domenico, additional, Schoemaker, Nico J., additional, Selleri, DMV, Paolo, additional, Siegel, Andrea, additional, Sladakovic, Izidora, additional, Smith, Susan M., additional, St-Vincent, Rachel S., additional, Steffey, Michele A., additional, Szabo, Zoltan, additional, Tarbell, Alison L., additional, Tully, Thomas N., additional, van der Woerdt, Alexandra, additional, van Zeeland, Yvonne R.A., additional, Varga, BVetMed, DZooMed, Molly, additional, Vella, BSc, David, additional, Walton, Raquel M., additional, Williams, Bruce H., additional, and Wyre, Nicole R., additional

Published
2021
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16. Cutaneous Histiocytosis in an Eastern Gray Squirrel (Sciurus carolinensis).

Author

Brown, Kelsey R., Clarke, Lorelei L., Lien, Molly, and Mans, Christoph

Abstract

A free-ranging Eastern gray squirrel (Sciurus carolinensis) was presented for ulcerated cutaneous masses at the base of both pinnae in July 2021. Diagnosis of cutaneous histiocytosis was achieved by histologic and immunohistochemical examination of one excised mass and supported by spontaneous resolution of the contralateral mass before the squirrel's release. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Contributors

Author

Alexander, Sarah, primary, Andrews, Kimberly M., additional, Baines, Frances M., additional, Barten, Stephen, additional, Bogan, James E., additional, Boyer, Donal M., additional, Boyer, Thomas H., additional, Bays, Teresa Bradley, additional, Brown, Mary B., additional, Camus, Melinda S., additional, Carmel, Brendan, additional, Carpenter, James W., additional, Chai, Norin, additional, Clayton, Leigh, additional, Comolli, Jessica R., additional, Connelly, Scott, additional, Cooper, John E., additional, Cooper, Margaret E., additional, Cusack, Lara M., additional, Cutler, Daniel, additional, Daneault, Andre, additional, Mattos de Souza Dantas, Leticia, additional, De Voe, Ryan, additional, DeNardo, Dale F., additional, Diethelm, Geraldine, additional, Divers, Stephen J., additional, Durso, Andrew M., additional, Eatwell, Kevin, additional, Ferguson, Bruce, additional, Ferrell, Shannon T., additional, Fitzgerald, Kevin T., additional, Franklin, Samuel P., additional, Funk, Richard S., additional, Gal, Janos, additional, Gibbons, Paul M., additional, Girling, Simon, additional, Gottdenker, Nicole, additional, Griffin, Chris, additional, Harms, Craig A., additional, Harrison, Tara M., additional, Heatley, J. Jill, additional, Hedley, Joanna, additional, Hellebuyck, Tom, additional, Hochleithner, Claudia, additional, Holmes, Shannon P., additional, Howerth, Elizabeth W., additional, Hunt, Craig J-G., additional, Innis, Charles J., additional, Johnson, Robert, additional, Johnson-Delaney, Cathy A., additional, Karlin, W. Michael, additional, Keller, Krista A., additional, Kik, Marja J.L., additional, Kischinovsky, Michelle, additional, Klaphake, Eric, additional, Knafo, S. Emi, additional, Knotek, Zdenek, additional, Lawton, Martin P.C., additional, Lewbart, Daniel T., additional, Lewbart, Gregory A., additional, Maas, Adolf, additional, Machin, Ross A., additional, Maerz, John C., additional, Mans, Christoph, additional, Marin, Maud L., additional, Marschang, Rachel E., additional, Martel, An, additional, Martínez-Silvestre, Albert, additional, Mathes, Karina A., additional, Mayer, Joerg, additional, McArthur, Stuart, additional, McDermott, Colin T., additional, Merck, Melinda, additional, Meyer, Jean, additional, Mitchell, Mark A., additional, Moore, Antony S., additional, Mustin, Walter, additional, Nagata, Koichi, additional, Nardini, Giordano, additional, Nevarez, Javier G., additional, Norton, Terry M., additional, Nowlan, Peter, additional, O'Rourke, Dorcas P., additional, Origgi, Francesco C., additional, Orós, Jorge, additional, Pardo, Mariana A., additional, Pasmans, Frank, additional, Pees, Michael, additional, Perry, Sean M., additional, Petritz, Olivia A., additional, Platt, Simon R., additional, Pye, Geoffrey W., additional, Rademacher, Nathalie, additional, Raiti, Paul, additional, Reavill, Drury R., additional, Retnam, Leslie, additional, Richardson, Jenna, additional, Rivera, Sam, additional, Rockwell, Kelly, additional, Rossi, John V., additional, Russell, Karen E., additional, Scheelings, T. Franciscus, additional, Schilliger, Lionel, additional, Schmidt, Volker, additional, Schnellbacher, Rodney W., additional, Schumacher, Juergen, additional, Scott, Peter W., additional, Selleri, Paolo, additional, Sharma, Ajay, additional, Shepard, Molly, additional, Simpson, Shane, additional, Skurski, Michelle L., additional, Sladakovic, Izidora, additional, Sladky, Kurt K., additional, Smith, Lora L., additional, Solano, Mauricio, additional, Son, Tolina Tina, additional, Stahl, Scott J., additional, Steagall, Paulo, additional, Walden, Heather D.S., additional, Wellehan, James F.X., additional, Wendland, Lori D., additional, West, Cynthia L., additional, Whitaker, Brent R., additional, Wilkinson, Stacey Leonatti, additional, Wüst, Elisa, additional, Wyneken, Jeanette, additional, Yau, Wilson, additional, Yaw, Taylor, additional, and Yeuroukis, Corry K., additional

Published
2019
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32. Contributors

Author

Adkesson, Michael J., primary, Aguilar-Calvo, Patricia, additional, de Alcantara, Bianca Nascimento, additional, Allender, Matthew C., additional, Arias-Bernal, Leonardo, additional, Asa, Cheryl, additional, Backues, Kay A., additional, Bailey, James E., additional, Bauman, Karen, additional, Belov, Katherine, additional, Bertelsen, Mad Frost, additional, Bezner, Jocelyn, additional, Bronson, Ellen, additional, Buss, Peter, additional, Cameron, Kenneth, additional, Campbell-Ward, Michelle, additional, Catenacci, Lilian Silva, additional, Chai, Norin, additional, Chinnadurai, Sathya K., additional, Christensen, Bruce, additional, Clancy, Meredith Martin, additional, Clayton, Leigh, additional, Colitz, Carmen M.H., additional, Cortes-Hinojosa, Galaxia, additional, Crespo-Picazo, José Luis, additional, Dadone, Liza, additional, Danforth, Marietta Dindo, additional, Deem, Sharon L., additional, Dench, Rosalie, additional, Desmarchelier, Marion Renée, additional, Di Girolamo, Nicola, additional, Di Nucci, Dante Luis, additional, Emerson, Jessica A., additional, Epstein, Jonathan H., additional, Erlacher-Reid, Claire, additional, Flanagan, Joseph P., additional, Fundak, Brett, additional, Gage, Laurie J., additional, Gamble, Kathryn C., additional, García-Párraga, Daniel, additional, Garner, Michael M., additional, Georoff, Timothy A., additional, Gilardi, Kirsten V.K., additional, Gilbert, Martin, additional, Goodman, Steven M., additional, Greenberg, Mark, additional, Greenwood, Alex David, additional, Grøndahl, Carsten, additional, Hadfield, Catherine, additional, Halpern, Bálint, additional, Hamer, Sarah, additional, Hammond, Elizabeth E., additional, Harman, Robert, additional, Hernandez, Sonia Maria, additional, Hodo, Carolyn, additional, Hofmeister, Erik, additional, Hogg, Carolyn J., additional, Howard, Lauren Lynn, additional, Ivančić, Marina, additional, Jankowski, Gwen, additional, Janssen, Donald L., additional, Juan-Sallés, Carles, additional, Khairani, Kurnia Oktavia, additional, Kinney, Matthew E., additional, Kleinschmidt, Laura M., additional, Kock, Richard Anthony, additional, Kozlowski, Corinne P., additional, Langan, Jennifer N., additional, Lécu, Alexis, additional, Lewbart, Gregory A., additional, Loyd, Kerrie Anne T., additional, Lüeders, Imke, additional, Mama, Khursheed, additional, Mans, Christoph, additional, Marschang, Rachel E., additional, Martelli, Paolo R., additional, Martinez, Gerardo, additional, Mazet, Jonna A.K., additional, McAloose, Denise, additional, Meteyer, Carol U., additional, Miller, Michele A., additional, Milnes, Ellie, additional, Molter, Christine, additional, Monsalve, Santiago, additional, Morkel, Pete, additional, Murphy, Hayley Weston, additional, Paul-Murphy, Joanne, additional, Nadler, Yvonne, additional, Napier, Julia E., additional, Nel, Pierre, additional, Nol, Pauline, additional, O'Sullivan, Sean, additional, Olea-Popelka, Francisco, additional, Osterrieder, Klaus, additional, Page-Karjian, Annie, additional, Paré, Jean A., additional, Pastor, Adriana, additional, Philippa, Joost, additional, Pieters, Wouter, additional, Portas, Timothy J., additional, Radcliffe, Robin W., additional, Raines, Jan, additional, Raphael, Bonnie L., additional, Rasambainarivo, Fidisoa, additional, Reed, Patricia, additional, Rhyan, Jack C., additional, Rideout, Bruce, additional, Roberts, John, additional, Robinson, Sarah, additional, Moreno, Gianmarco Rojas, additional, Rosen, Laura Elizabeth, additional, Rush, Elizabeth Marie, additional, Guzman, David Sanchez-Migallon, additional, Schaftenaar, Willem, additional, Schirmacher, Michael R., additional, Schmidt, Debra A., additional, Seeley, Kathryn E., additional, Shaw, Michelle E., additional, Sigurdson, Christina J., additional, Sladky, Kurt K., additional, Smith, Dale, additional, Smith, Kristine, additional, Sós, Endre, additional, Steenkamp, Gerhard, additional, Styles, Darrel K., additional, Suk-Wai, Hui, additional, Sullivan, Kathleen E., additional, Sykes, John M., additional, Talbot, Jessica J., additional, Tapia, Washington, additional, Terio, Karen A., additional, Terrell, Scott, additional, Toosy, Arshad Haroon, additional, Travis, Dominic A., additional, Tuxbury, Kathryn A., additional, Valdes, Eduardo V., additional, Van Hemert, Caroline, additional, Vance, Carrie K., additional, Verant, Michelle L., additional, Vogelnest, Larry, additional, Walzer, Chris, additional, Wellehan, Jim, additional, Wiedner, Ellen, additional, Wolff, Peregrine L., additional, Yarto-Jaramillo, Enrique, additional, and Zuba, Jeffery R., additional

Published
2019
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43. Contributors

Author

Barron, Heather W., primary, Beaufrére, Hugues, additional, Brust, David M., additional, Carpenter, James W., additional, Fisher, Peter, additional, Gamble, Kathryn C., additional, Gibbons, Paul M., additional, Graham, Jennifer, additional, Greenacre, Cheryl B., additional, Guzman, David Sanchez-Migallon, additional, Hawkins, Michelle G., additional, Helmer, Peter J., additional, Johnston, Matthew S., additional, Klaphake, Eric, additional, Lennox, Angela M., additional, Lewbart, Gregory A., additional, Lynne Luna, G., additional, Mans, Christoph, additional, Mayer, Jörg, additional, McDermott, Colin T., additional, McRuer, David, additional, Morishita, Teresa Y., additional, Morrisey, James K., additional, Mozzachio, Kristie, additional, Sladky, Kurt K., additional, Swenson, Julie, additional, Tynes, Valarie V., additional, Whitaker, Brent, additional, and Yanong, Roy P.E., additional

Published
2018
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46. Long-term systemic antibiotics and surgical treatment can be an effective treatment option for retrobulbar abscesses in rabbits (Oryctolagus cuniculus): 21 cases (2011-2022).

Author

Levy, Ivana and Mans, Christoph

Subjects
*EUROPEAN rabbit, *MEDICAL record databases, *RABBITS, *ABSCESSES, *THERAPEUTICS
Abstract

OBJECTIVE: To characterize the epidemiologic features of rabbits with retrobulbar abscesses, including the clinical signs, diagnosis, treatment, and outcome. ANIMALS: 21 client-owned rabbits. METHODS: The medical record database of a veterinary teaching hospital was searched from 2011 to 2022 for records of rabbits diagnosed with retrobulbar abscesses by CT. Data reviewed included age, breed, presenting complaint, association with an odontogenic infection, aerobic and anaerobic culture results, treatment, and outcome. RESULTS: The primary presenting complaint was exophthalmos (19/21 [90%]). Most cases (15/21 [71%]) were associated with an odontogenic infection. Dental disease, not associated with a retrobulbar abscess (14/21 [67%]), was a common comorbidity on CT. The most common aerobic and anaerobic isolates were Streptococcus intermedius (5/12 [42%]) and Fusobacterium nucleatum (2/12 [17%]), respectively. Surgical treatment combined with long-term systemic antibiotic therapy was performed in 9 of 21 (43%) cases. It included intraoral tooth extraction (4/9 [44%]) versus extraoral peribulbar abscess lancing with either abscess packing with antibiotic-soaked gauze (3/9 [33%]) or surgical abscess debridement (2/9 [22%]). Resolution of the clinical signs with no recurrence for at least 6 months occurred in 7 of 9 (78%) surgically treated cases. Medical treatment with long-term systemic antibiotic therapy was performed in 4 of 21 (19%) cases, and 3 of 4 (75%) resolved. Due to poor prognosis or financial concerns, euthanasia was performed or recommended in 8 of 21 (38%) cases. CLINICAL RELEVANCE: On the basis of the data from this study, retrobulbar abscesses in rabbits carry a guarded prognosis. When intraoral and extraoral surgical treatment options combined with systemic antibiotic therapy were used, it resolved clinical disease in most cases. [ABSTRACT FROM AUTHOR]

Published
2023
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47. Subconjunctival enucleation with or without third eyelid removal may present a viable enucleation technique in rabbits: 18 cases (2014-2022).

Author

Hiebert, Kara, Mans, Christoph, and Eaton, Seth

Subjects
*EYELIDS, *RABBITS, *NOSEMA cuniculi, *SURGICAL complications, *VETERINARY hospitals, RABBIT diseases
Abstract

OBJECTIVE To evaluate intraoperative and postoperative complications and outcomes following subconjunctival enucleations with and without third eyelid removal in domestic rabbits. ANIMALS 18 client-owned rabbits with ocular disease confined to the globe that underwent 20 subconjunctival enucleation procedures at a veterinary teaching hospital. METHODS Records were retrospectively reviewed for all enucleations performed at a veterinary teaching hospital from 2014 to 2022. A standard subconjunctival enucleation procedure was performed in all cases, with third eyelid removal in 2 surgeries and without third eyelid removal in the remaining 18 surgeries. Outcomes were assessed on the basis of observations in medical records and owner follow-up. RESULTS 20 total enucleations were included. Reported reasons for enucleation included suspected or confirmed ocular Encephalitozoon cuniculi infection in 9 rabbits, refractory glaucoma in 4 rabbits, and various intraoculardiseases in 5 rabbits. The only intraoperative complication reported was hemorrhage during the third eyelid removal in 1 surgery. Postoperative complications included serous to mucoid discharge from the surgical site in 8 of 20 surgeries and swelling at the surgery site in 2 of the 8 cases that had discharge. Postoperative swelling spontaneously resolved within 3 months of surgery; postoperative discharge spontaneously resolved within 10 months of surgery. CLINICAL RELEVANCE Subconjunctival enucleation with or without third eyelid removal in rabbits may be a viable enucleation technique to reduce the risk for intraoperative hemorrhage, but it can result in postoperative complications, including transient discharge and swelling at the surgical site. [ABSTRACT FROM AUTHOR]

Published
2023
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