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480 results on '"Manolopoulos, Vangelis G"'

4. Exploring Microbial Metabolite Receptors in Inflammatory Bowel Disease: An In Silico Analysis of Their Potential Role in Inflammation and Fibrosis

Author

Spathakis, Michail, primary, Dovrolis, Nikolas, additional, Filidou, Eirini, additional, Kandilogiannakis, Leonidas, additional, Tarapatzi, Gesthimani, additional, Valatas, Vassilis, additional, Drygiannakis, Ioannis, additional, Paspaliaris, Vasilis, additional, Arvanitidis, Konstantinos, additional, Manolopoulos, Vangelis G., additional, Kolios, George, additional, and Vradelis, Stergios, additional

Published
2024
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6. Landscape of Interactions between Stromal and Myeloid Cells in Ileal Crohn's Disease; Indications of an Important Role for Fibroblast-Derived CCL-2.

Author

Dovrolis, Nikolas, Valatas, Vassilis, Drygiannakis, Ioannis, Filidou, Eirini, Spathakis, Michail, Kandilogiannakis, Leonidas, Tarapatzi, Gesthimani, Arvanitidis, Konstantinos, Bamias, Giorgos, Vradelis, Stergios, Manolopoulos, Vangelis G., Paspaliaris, Vasilis, and Kolios, George

Subjects
CROHN'S disease, INFLAMMATORY bowel diseases, MYELOID cells, STROMAL cells, CELL anatomy
Abstract

Background and aims: Monocyte recruitment in the lamina propria and inflammatory phenotype driven by the mucosal microenvironment is critical for the pathogenesis of inflammatory bowel disease. However, the stimuli responsible remain largely unknown. Recent works have focused on stromal cells, the main steady-state cellular component in tissue, as they produce pro-inflammatory chemokines that contribute to the treatment-resistant nature of IBD. Methods: We studied the regulation of these processes by examining the communication patterns between stromal and myeloid cells in ileal Crohn's disease (CD) using a complete single-cell whole tissue sequencing analysis pipeline and in vitro experimentation in mesenchymal cells. Results: We report expansion of S4 stromal cells and monocyte-like inflammatory macrophages in the inflamed mucosa and describe interactions that may establish sustained local inflammation. These include expression of CCL2 by S1 fibroblasts to recruit and retain monocytes and macrophages in the mucosa, where they receive signals for proliferation, survival, and differentiation to inflammatory macrophages from S4 stromal cells through molecules such as MIF, IFNγ, and FN1. The overexpression of CCL2 in ileal CD and its stromal origin was further demonstrated in vitro by cultured mesenchymal cells and intestinal organoids in the context of an inflammatory milieu. Conclusions: Our findings outline an extensive cross-talk between stromal and myeloid cells, which may contribute to the onset and progression of inflammation in ileal Crohn's disease. Understanding the mechanisms underlying monocyte recruitment and polarization, as well as the role of stromal cells in sustaining inflammation, can provide new avenues for developing targeted therapies to treat IBD. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Analysis of the current situation of pharmacogenomics in terms of educational and healthcare needs in Egypt and Lebanon.

Author

El-Gowilly, Sahar M, Metwaly, Heba A, Makhlouf, Dalia, Elmansoury, Nehal, Abuiessa, Salwa A, Sorour, Amani A, Abdelgalil, Mohamed Hussein, Fawaz, Mirna, Abushady, Asmaa M, Gamaleldin, Mariam, Abdelghany, Tarek M, Fakhoury, Rajaa, Abdelhady, Rasha, Ghanim, Amal MH, Shehata, Samah, Kamal, Marwa, Bahy, Rehab, Haroon, Sanaa A, Manolopoulos, Vangelis G, and Cascorbi, Ingolf

Published
2024
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13. Implementing pharmacogenetic testing in fluoropyrimidine-treated cancer patients: DPYD genotyping to guide chemotherapy dosing in Greece

Author

Ragia, Georgia, primary, Maslarinou, Anthi, additional, Atzemian, Natalia, additional, Biziota, Eirini, additional, Koukaki, Triantafyllia, additional, Ioannou, Charalampia, additional, Balgkouranidou, Ioanna, additional, Kolios, George, additional, Kakolyris, Stylianos, additional, Xenidis, Nikolaos, additional, Amarantidis, Kyriakos, additional, and Manolopoulos, Vangelis G., additional

Published
2023
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17. Niclosamide Attenuates Inflammation-Associated Profibrotic Responses in Human Subepithelial Lung Myofibroblasts

Author

Spathakis, Michail, primary, Tarapatzi, Gesthimani, additional, Filidou, Eirini, additional, Kandilogiannakis, Leonidas, additional, Karatzas, Evangelos, additional, Steiropoulos, Paschalis, additional, Mikroulis, Dimitrios, additional, Spyrou, George M., additional, Manolopoulos, Vangelis G., additional, Kolios, George, additional, and Arvanitidis, Konstantinos, additional

Published
2023
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19. Role of Lactiplantibacillus plantarum UBLP-40, Lactobacillus rhamnosus UBLR-58 and Bifidobacterium longum UBBL-64 in the Wound Healing Process of the Excisional Skin

Author

Panagiotou, Dimitrios, primary, Filidou, Eirini, additional, Gaitanidou, Maria, additional, Tarapatzi, Gesthimani, additional, Spathakis, Michail, additional, Kandilogiannakis, Leonidas, additional, Stavrou, George, additional, Arvanitidis, Konstantinos, additional, Tsetis, Joulia K., additional, Gionga, Persefoni, additional, Shrewsbury, Anne D., additional, Manolopoulos, Vangelis G., additional, Kapoukranidou, Dora, additional, Lasithiotakis, Konstantinos, additional, Kolios, George, additional, and Kotzampassi, Katerina, additional

Published
2023
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20. The Sixth European Society of Pharmacogenomics and Personalised Therapy Congress

Author

Van Schaik, Ron H.N., Manolopoulos, Vangelis G., Daly, Ann K., Niemi, Mikko, Zukic, Branka, Patrinos, George P., Primorac, Dragan, Swen, Jesse J., Ingelman-Sundberg, Magnus, Morris, Tiffany, Molden, Espen, Müller, Daniel, Pavlovic, Sonja, Russmann, Stefan, Ansari, Marc, Henricks, Linda M., Van Den Broek, Wout, Florindi, Francesco, Bozina, Nada, Akin, Demet, Christrup, Lona, Llerena, Adrian, Sipeky, Cilla, Stankovic, Sanja, Van Schaik, Ron H.N., Manolopoulos, Vangelis G., Daly, Ann K., Niemi, Mikko, Zukic, Branka, Patrinos, George P., Primorac, Dragan, Swen, Jesse J., Ingelman-Sundberg, Magnus, Morris, Tiffany, Molden, Espen, Müller, Daniel, Pavlovic, Sonja, Russmann, Stefan, Ansari, Marc, Henricks, Linda M., Van Den Broek, Wout, Florindi, Francesco, Bozina, Nada, Akin, Demet, Christrup, Lona, Llerena, Adrian, Sipeky, Cilla, and Stankovic, Sanja

Abstract

On 8-9 November 2022, the European Society of Pharmacogenomics and Personalised Therapy organized its sixth biennial congress, in Belgrade, Serbia (congress website: www.sspt.rs). The congress aimed to address the current status and future perspectives of pharmacogenomics, share latest knowledge in the field of precision medicine and showcase the implementation of clinical applications in pharmacogenomics/pharmacogenetics. The 2 day congress consisted of 17 lectures given by key-opinion leaders and included a poster session plus discussions. The meeting was a great success by generating an informal environment and enabling the exchange of information between 162 participants from 16 different countries.

Published
2023

22. Co-expression of fibrotic genes in inflammatory bowel disease; A localized event?

Author

Dovrolis, Nikolas, primary, Filidou, Eirini, additional, Tarapatzi, Gesthimani, additional, Kokkotis, Georgios, additional, Spathakis, Michail, additional, Kandilogiannakis, Leonidas, additional, Drygiannakis, Ioannis, additional, Valatas, Vassilis, additional, Arvanitidis, Konstantinos, additional, Karakasiliotis, Ioannis, additional, Vradelis, Stergios, additional, Manolopoulos, Vangelis G., additional, Paspaliaris, Vasilis, additional, Bamias, Giorgos, additional, and Kolios, George, additional

Published
2022
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26. The Probiotic Strains Bifidοbacterium lactis, Lactobacillus acidophilus, Lactiplantibacillus plantarum and Saccharomyces boulardii Regulate Wound Healing and Chemokine Responses in Human Intestinal Subepithelial Myofibroblasts

Author

Tarapatzi, Gesthimani, primary, Filidou, Eirini, additional, Kandilogiannakis, Leonidas, additional, Spathakis, Michail, additional, Gaitanidou, Maria, additional, Arvanitidis, Konstantinos, additional, Drygiannakis, Ioannis, additional, Valatas, Vassilis, additional, Kotzampassi, Katerina, additional, Manolopoulos, Vangelis G., additional, Kolios, George, additional, and Vradelis, Stergios, additional

Published
2022
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29. Pharmacogenomics of alcohol addiction: Personalizing pharmacologic treatment of alcohol dependence

Author

Ragia Georgia and Manolopoulos Vangelis G.

Subjects
alcohol, addiction, naltrexone, topiramate, disulfiram, acamprosate, pharmacogenetics, personalized drug treatment, hospital pharmacology, Therapeutics. Pharmacology, RM1-950
Abstract

Alcohol dependence is a serious psychiatric disorder with harmful physical, mental and social consequences, and a high probability of a chronic relapsing course. The field of pharmacologic treatment of alcohol dependence and craving is expanding rapidly; the drugs that have been found to reduce relapse rates or drinking in alcohol-dependent patients and are approved for treatment of alcohol dependence are naltrexone, acamprosate and disulfiram, whereas also topiramate appears as a promising therapy. For many patients, however, these treatments are not effective. Evidence from a number of different studies suggests that genetic variation is a significant contributor to interindividual variation of clinical presentation of alcohol problems and response to a given treatment. The aim of the present review is to summarize and discuss the findings on the association between gene polymorphisms and the response to alcohol dependence treatment medications. It is anticipated that future implementation of pharmacogenomics in clinical practice will help personalize alcohol dependence drug treatment, and development personalized hospital pharmacology.

Published
2014
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31. Endothelial nitric oxide synthase gene polymorphisms -786T >C and 894G >T in coronary artery bypass graft surgery patients

Author

Ragia Georgia, Nikolaidis Eleftherios, Tavridou Anna, Arvanitidis Kostas I, Kanoni Stavroula, Dedoussis George V, Bougioukas George, and Manolopoulos Vangelis G

Subjects
coronary artery disease, coronary artery bypass graft surgery, +C+polymorphism%2C+eNOS+894G+>+T+polymorphism%22">eNOS -786T > C polymorphism, eNOS 894G > T polymorphism, smoking, Medicine, Genetics, QH426-470
Abstract

Abstract Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene (-786T >C and 894G >T) enhance endo-thelial dysfunction and have been studied in relation to coronary artery disease (CAD). In the present study, we examined the association of the above polymorphisms with CAD, as well as with myocardial infarction (MI), hypertension, diabetes and smoking in CAD patients. Study subjects consisted of 154 consecutive coronary artery bypass graft (CABG) patients and 155 non-CAD controls. eNOS -786T >C and 894G >T polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism. The estimated frequencies of the -786C and 894T alleles did not differ between the two groups (p = 0.46 and p = 0.84, respectively). The prevalence of eNOS polymorphisms was not associated with MI, hypertension or diabetes in CABG patients; however, we found that the 894TT genotype and 894T allele were significantly more frequent in current/past smoker CABG patients (16.7 per cent and 39.6 per cent, respectively) compared with never smoker CABG patients (6.1 per cent and 24.4 per cent, respectively) (p = 0.01 and p < 0.01, respectively). We found no association of eNOS -786C and 894T variant alleles with CAD; however, within CABG patients, a gene-environment interaction was found between the eNOS 894T allele and smoking.

Published
2010
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38. The Probiotic Strains Bifid οbacterium lactis, Lactobacillus acidophilus,   Lactiplantibacillus plantarum and Saccharomyces boulardii Regulate Wound Healing and Chemokine Responses in Human Intestinal Subepithelial Myofibroblasts.

Author

Tarapatzi, Gesthimani, Filidou, Eirini, Kandilogiannakis, Leonidas, Spathakis, Michail, Gaitanidou, Maria, Arvanitidis, Konstantinos, Drygiannakis, Ioannis, Valatas, Vassilis, Kotzampassi, Katerina, Manolopoulos, Vangelis G., Kolios, George, and Vradelis, Stergios

Subjects
PROBIOTICS, WOUND healing, MYOFIBROBLASTS, LACTOBACILLUS acidophilus, BIFIDOBACTERIUM, SACCHAROMYCES, MACROPHAGE inflammatory proteins, INTESTINES
Abstract

Bifidobacterium lactis, Lactobacillus acidophilus, Lactiplantibacillus plantarum and Saccharomyces boulardii are common probiotic supplements. Colonic subepithelial myofibroblasts (cSEMFs) are actively involved in mucosal wound healing and inflammation. cSEMFs, isolated from healthy individuals, were stimulated with 102 or 104 cfu/mL of these probiotic strains alone and in combination, and their effect on chemokine and wound healing factor expression was assessed by qRT-PCR, ELISA and Sircol Assay, and on cSEMFs migration, by Wound Healing Assay. These strains remained viable and altered cSEMFs' inflammatory and wound healing behavior, depending on the strain and concentration. cSEMFs treated with a combination of the four probiotics had a moderate, but statistically significant, increase in the mRNA and/or protein expression of chemokines CXCL1, CXCL2, CXCL4, CXCL8, CXCL10, CCL2 and CCL5, and healing factors, collagen type I and III, fibronectin and tissue factor. In contrast, when each strain was administered alone, different effects were observed, with greater increase or decrease in chemokine and healing factor expression, which was balanced by the mixture. Overall, this study highlights that the use of multiple probiotic strains can potentially alert the gut mucosal immune system and promote wound healing, having a better effect on mucosal immunity than the use of single probiotics. [ABSTRACT FROM AUTHOR]

Published
2022
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44. A global view of the OCA2-HERC2 region and pigmentation

Author

Donnelly, Michael P., Paschou, Peristera, Grigorenko, Elena, Gurwitz, David, Barta, Csaba, Lu, Ru-Band, Zhukova, Olga V., Kim, Jong-Jin, Siniscalco, Marcello, New, Maria, Li, Hui, Kajuna, Sylvester L. B., Manolopoulos, Vangelis G., Speed, William C., Pakstis, Andrew J., Kidd, Judith R., and Kidd, Kenneth K.

Published
2012
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46. The distribution and most recent common ancestor of the 17q21 inversion in humans

Author

Donnelly, Michael P., Grigorenko, Elena, Gurwitz, David, Mehdi, Syed Qasim, Paschou, Peristera, Kajuna, Sylvester L.B., Barta, Csaba, Kungulilo, Selemani, Karoma, N.J., Ru-Band Lu, Zhukova, Olga V., Jong-Jin Kim, Comas, David, Siniscalco, Marcello, New, Maria, Peining Li, Manolopoulos, Vangelis G., Hui Li, Speed, William C., Rajeevan, Haseena, Pakstis, Andrew J., Kidd, Judith R., and Kidd, Kenneth K.

Subjects
Proteins -- Research, Human genetics -- Research, Genetic polymorphisms -- Research, Inversion (Genetics) -- Research, Biological sciences
Abstract

Studies offer insights into the geographical and racial distribution of the polymorphic inversion on 17q21, also called the microtubular associated protein tau (MAPT) inversion) in humans. Data analysis also suggests that the most recent common ancestor for the H2 haplotype inversion could be dated at about 13,600 to 108, 400 years earlier, much more recent than the 3 million year date previously suggested.

Published
2010

49. Association of rs11780592 Polymorphism in the Human Soluble Epoxide Hydrolase Gene (EPHX2) with Oxidized LDL and Mortality in Patients with Diabetic Chronic Kidney Disease

Author

Roumeliotis, Stefanos, primary, Roumeliotis, Athanasios, additional, Stamou, Aikaterini, additional, Panagoutsos, Stylianos, additional, Manolopoulos, Vangelis G., additional, Tsetsos, Fotis, additional, Georgitsi, Marianthi, additional, and Liakopoulos, Vassilios, additional

Published
2021
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