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Objectives: The present study was aimed to observe the antibiotic microbial sensitivity patterns in type II Diabetes Mellitus patients with Urinary tract infections. Methods: A retrospective study was conducted in the Department of Endocrinology and Metabolism at Sri Venkateswara Institute of Medical Sciences, Tirupati during a period of 6 months (July to December 2019). 120 culture urine samples were taken for the study as per inclusion and exclusion criteria. All the data were collected, recorded, tabulated and analysed using Microsoft Excel worksheet (Microsoft Corp, Redmond, WA). Continuous and categorical data were expressed in terms of mean ± Standard deviation (SD) and percentage respectively. Antibiotic microbial sensitivity was expressed in terms of percentage. Results: Out of the total of 120 subjects, the most commonly affected age group was 51- 60 years (33.33%). Here females (55%) dominated males (45%) in number. Most commonly isolated Gram-negative organisms were Escherichia coli (35%) and Enterococcus faecalis (15.8%) whereas Gram-positive organisms were Enterococcus faecalis (17.6%) and Staphylococcus aureus (9.16%). Most of the gram-negative bacteria were having a good sensitivity to amikacin (56.75%) and gram-positive bacteria were mostly sensitive to nitrofurantoin (46%). Conclusion: Escherichia coli was the major isolated micro-organism followed by Enterococcus and Klebsiella. Amikacin showed more sensitivity towards gram-negative organisms, whereas Nitrofurantoin showed more sensitivity towards gram-positive organisms. Most uropathogens isolated in Type II Diabetes mellitus were sensitive to Amikacin. This study enlists certain antibiotics which can be used as firstline agents by the physician while awaiting for urine microscopic culture sensitivity results. Key words: Diabetes Mellitus, Retrospective Study, Urinary Tract Infection, Antibiotic Sensitivity, Gram-Positive Organisms, Gram-Negative Organisms.