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21 results on '"Manoharan-Basil, Sheeba S."'

6. The Discovery of Oropharyngeal Microbiota with Inhibitory Activity against Pathogenic Neisseria gonorrhoeae and Neisseria meningitidis: An In Vitro Study of Clinical Isolates

Author

Akomoneh, Elvis Achondou, primary, Laumen, Jolein Gyonne Elise, additional, Abdellati, Saïd, additional, Van Dijck, Christophe, additional, Vanbaelen, Thibau, additional, Britto, Xavier Basil, additional, Manoharan-Basil, Sheeba S., additional, and Kenyon, Chris, additional

Published
2022
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9. Sub-Inhibitory Concentrations of Chlorhexidine Induce Resistance to Chlorhexidine and Decrease Antibiotic Susceptibility in Neisseria gonorrhoeae

Author

Laumen, Jolein G. E., primary, Van Dijck, Christophe, additional, Manoharan-Basil, Sheeba S., additional, Abdellati, Saïd, additional, De Baetselier, Irith, additional, Cuylaerts, Vicky, additional, De Block, Tessa, additional, Van den Bossche, Dorien, additional, Xavier, Basil B., additional, Malhotra-Kumar, Surbhi, additional, and Kenyon, Chris, additional

Published
2021
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17. Surprisal analysis of genome-wide transcript profiling identifies differentially expressed genes and pathways associated with four growth conditions in the microalga Chlamydomonas

Author

Bogaert, Kenny A., Manoharan-Basil, Sheeba S., Perez, Emilie, Levine, Raphael D., Remacle, Francoise, and Remacle, Claire

Subjects
Algae, lcsh:Medicine, Gene Expression, Plant Science, Biosynthesis, Research and Analysis Methods, Biochemistry, Phosphates, Model Organisms, Plant and Algal Models, Gene Expression Regulation, Plant, Genetics, Microalgae, Photosynthesis, lcsh:Science, Chlamydomonas Reinhardtii, Plant Biochemistry, Gene Expression Profiling, lcsh:R, Chlamydomonas, Organisms, Chemical Compounds, Biology and Life Sciences, Eukaryota, Computational Biology, Gene Expression Regulation, Developmental, Genomics, Plants, Genome Analysis, Phenotypes, Chemistry, Metabolism, Experimental Organism Systems, RNA, Plant, Physical Sciences, lcsh:Q, Metabolic Pathways, Transcriptome, Transcriptome Analysis, Genome, Plant, Research Article, Signal Transduction
Abstract

The usual cultivation mode of the green microalga Chlamydomonas is liquid medium and light. However, the microalga can also be grown on agar plates and in darkness. Our aim is to analyze and compare gene expression of cells cultivated in these different conditions. For that purpose, RNA-seq data are obtained from Chlamydomonas samples of two different labs grown in four environmental conditions (agar@light, agar@dark, liquid@light, liquid@dark). The RNA seq data are analyzed by surprisal analysis, which allows the simultaneous meta-analysis of all the samples. First we identify a balance state, which defines a state where the expression levels are similar in all the samples irrespectively of their growth conditions, or lab origin. In addition our analysis identifies additional constraints needed to quantify the deviation with respect to the balance state. The first constraint differentiates the agar samples versus the liquid ones; the second constraint the dark samples versus the light ones. The two constraints are almost of equal importance. Pathways involved in stress responses are found in the agar phenotype while the liquid phenotype comprises ATP and NADH production pathways. Remodeling of membrane is suggested in the dark phenotype while photosynthetic pathways characterize the light phenotype. The same trends are also present when performing purely statistical analysis such as K-means clustering and differentially expressed genes.

Published
2018

18. Gonorrhoea treatment combined with population-level general cephalosporin and quinolone consumption may select for Neisseria gonorrhoeaeantimicrobial resistance at the levels of NG-MAST genogroup: An ecological study in Europe

Author

Kenyon, Chris, Laumen, Jolein, Van Dijck, Christophe, De Baetselier, Irith, Abdelatti, Saïd, Manoharan-Basil, Sheeba S., and Unemo, Magnus

Abstract

•N. gonorrhoeaegenogroup G1407 is strongly associated with decreased susceptibility to cephalosporins and fluoroquinolones.•Prevalence of G1407 has declined overall in Europe but switched from being associated with MSM to heterosexuals.•Change in national prevalence of G1407 in Europe was positively associated with population-level general cephalosporin and quinolone consumption.•Results suggest that changes in gonorrhoea therapy to more efficacious ceftriaxone resulted in reduced prevalence of the resistance-associated G1407 overall but in MSM in particular.•High population-level consumption of quinolones and cephalosporins in certain countries contributed to the selection of G1407 predominantly in heterosexuals.

Published
2020
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20. Peltigera islandica, a new cyanolichen species in section Peltigera (‘P. canina group’).

Author

MANOHARAN-BASIL, Sheeba S., MIADLIKOWSKA, Jolanta, GOWARD, Trevor, ANDRÉSSON, Ólafur S., and MIAO, Vivian P. W.

Subjects
*PELTIGERA, *LICHENS, *NOSTOC, *LICHENOLOGY
Abstract

A new cyanolichen, Peltigera islandica sp. nov. in the section Peltigera (‘P. canina group’) is described from Iceland. This species is similar in general appearance to P. rufescens and P. membranacea, but may be recognized by its downturned lobe tips and narrow lobes, respectively. Most thalli are bright emerald green in colour when moist, although a dark khaki green colourmorph is also documented. Monophyly of P. islandica s. lat. (i.e. including P. sp. A sensu O’Brien et al., from Canada) is significantly supported based on ITS sequences and corroborated by molecular synapomorphy (absence of the ITS1 hypervariable region). Analysis of the rbcLX locus indicates the cyanobiont of P. islandica (Nostoc sp.) comprises strains belonging to a pool of Icelandic genotypes, some of which are present in other Peltigera species, including P. “neorufescens”, another taxon new to Iceland collected during this study. Association with photobionts that are shared by other local species suggests P. islandica may be well established in Iceland, but a review of herbarium collections as well as broader field surveys are needed to better characterize its geographical distribution. [ABSTRACT FROM PUBLISHER]

Published
2016
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21. Markedly Reduced Azithromycin and Ceftriaxone Susceptibility in Commensal Neisseria Species in Clinical Samples From Belgian Men Who Have Sex With Men.

Author

Laumen, Jolein G E, Dijck, Christophe Van, Abdellati, Said, Manoharan-Basil, Sheeba S, Baetselier, Irith De, Martiny, Delphine, Crucitti, Tania, and Kenyon, Chris

Subjects
ANTIBIOTICS, CEPHALOSPORINS, CIPROFLOXACIN, DRUG resistance, GONORRHEA, NEISSERIA infections, MEN who have sex with men, CEFTRIAXONE
Published
2021
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