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39 results on '"Mano, Yoshinori"'

1. Burden of Mild (

Author

Hashimoto, Kenji, Kimura, Takehiro, Ikemura, Nobuhiro, Katsumata, Yoshinori, Fujisawa, Taishi, Miyama, Hiroshi, Yamashita, Terumasa, Nakamura, Iwao, Mano, Yoshinori, Oki, Takahiro, Fukuda, Keiichi, Kohsaka, Shun, and Takatsuki, Seiji

Published
2021
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7. Burden of Mild (<13 g/dl) Anemia in Patients With Atrial Fibrillation (A Report from a Multicenter Registry With Patient-Reported Outcomes)

Author

Hashimoto, Kenji, primary, Kimura, Takehiro, additional, Ikemura, Nobuhiro, additional, Katsumata, Yoshinori, additional, Fujisawa, Taishi, additional, Miyama, Hiroshi, additional, Yamashita, Terumasa, additional, Nakamura, Iwao, additional, Mano, Yoshinori, additional, Oki, Takahiro, additional, Fukuda, Keiichi, additional, Kohsaka, Shun, additional, and Takatsuki, Seiji, additional

Published
2021
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8. Increased C-reactive protein expression exacerbates left ventricular dysfunction and remodeling after myocardial infarction

Author

Takahashi, Toshiyuki, Anzai, Toshihisa, Kaneko, Hidehiro, Mano, Yoshinori, Anzai, Atsushi, Nagai, Toshiyuki, Kohno, Takashi, Maekawa, Yuichiro, Yoshikawa, Tsutomu, Fukuda, Keiichi, and Ogawa, Satoshi

Subjects
Heart attack -- Genetic aspects, C-reactive protein -- Properties, Gene expression -- Physiological aspects, Heart ventricle, Left -- Genetic aspects, Biological sciences
Abstract

We previously reported serum C-reactive protein (CRP) elevation after acute myocardial infarction (MI) to be associated with adverse outcomes including cardiac rupture, left ventricular (LV) remodeling, and cardiac death. Experimental studies have indicated that CRP per se has various biological actions including proinflammatory and proapoptotic effects, suggesting a pathogenic role of CRP in the post-MI remodeling process. We tested the hypothesis that increased CRP expression would exacerbate adverse LV remodeling after MI via deleterious effects of CRP. Transgenic mice with human CRP expression (CRP-Tg) and their transgene-negative littermates (control) underwent left coronary artery ligation. There was no apparent difference in phenotypic features between CRP-Tg and control mice before MI. Although mortality and infarct size were similar in the two groups, CRP-Tg mice showed more LV dilation and worse LV function with more prominent cardiomyocyte hypertrophy and fibrosis in the noninfarcted regions after MI than controls. Histological evaluation conducted 1 wk post-MI revealed a higher rate of apoptosis and more macrophage infiltration in the border zones of infarcted hearts from CRP-Tg mice in relation to increased monocyte chemotactic protein (MCP)-1 expression and matrix metalloproteinase (MMP)-9 activity. Increased CRP expression exacerbates LV dysfunction and promotes adverse LV remodeling after MI in mice. The deleterious effect of CRP on post-MI LV remodeling may be associated with increased apoptotic rates, macrophage infiltration, MCP-1 expression, and MMP-9 activity in the border zone. macrophage; apoptosis doi: 10.1152/ajpheart.00001.2010.

Published
2010

13. Prevalence, Clinical Profile, and In-Hospital Outcomes of Sleep-Disordered Breathing in Patients Undergoing Transcatheter Aortic Valve Implantation in Japan

Author

Mano, Yoshinori, primary, Kohno, Takashi, additional, Hayashida, Kentaro, additional, Fukuoka, Ryoma, additional, Yanagisawa, Ryo, additional, Tanaka, Makoto, additional, Yashima, Fumiaki, additional, Tsuruta, Hikaru, additional, Itabashi, Yuji, additional, Murata, Mitsushige, additional, and Fukuda, Keiichi, additional

Published
2019
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14. Disruption of the interaction between retinoblastoma protein and 70 kD heat shock protein leads to growth acceleration of tumor cells

Author

Hatamoto, Keisuke, Torigoe, Toshihiko, Mano, Yoshinori, Asai, Yasufumi, and Sato, Noriyuki

Subjects
Heat shock, Retinoblastoma protein, TAT, biological phenomena, cell phenomena, and immunity, HSP70, Cell proliferation
Abstract

Retinoblastoma protein (pRb) is a phosphoprotein regulating cell growth. During G1 phase in the cell cycle, pRb is dephosphorylated and inhibits the progression to S phase. Previously we demonstrated that 70 kDa heat shock protein (HSP70) was associated with dephosphorylated pRb in vivo and in vitro, and mapped the HSP70 binding region of pRb. In this report we analyzed the consequences of disruption of the HSP70-pRb interaction in cells. Recombinant fusion proteins containing the 11 amino acid HIV TAT transduction domain and HSP70 binding domain (residues 301-372, RbHBD) or N-terminal non-binding region of pRb (RbNTR) were produced. The TAT fusion proteins were introduced into cells by addition into culture medium. TAT-RbHBD protein, but not TAT-RbNTR protein, was capable of binding to HSP 70 in the cells. Transduction of TAT-RbHBD protein inhibited the association of HSP70 to pRb in cells; however, TAT-RbNTR fusion protein failed to do so. Strikingly, transduction of TAT-RbHBD fusion protein promoted proliferation of HOS cells, Jurkat cells and U-937 cells expressing functional pRb, but not of SAOS cells lacking pRb. In addition, HOS cells treated with heat shock became more resistant to the effect of TAT-RbHBD protein. These data indicate that disruption of the HSP70-pRb interaction leads to growth acceleration of cells. Our study revealed an important in vivo role of HSP700-pRb interaction in cell cycle control.

Published
2006

22. EICOSAPENTAENOIC ACID SUPPRESSES THE ADVERSE EFFECTS OF C-REACTIVE PROTEIN OVEREXPRESSION ON PRESSURE OVERLOAD-INDUCED CARDIAC REMODELING VIA ATTENUATING INFLAMMATORY RESPONSE AND OXIDATIVE STRESS

Author

Nagai, Toshiyuki, primary, Anzai, Toshihisa, additional, Kaneko, Hidehiro, additional, Mano, Yoshinori, additional, Anzai, Atsushi, additional, Maekawa, Yuichiro, additional, Takahashi, Toshiyuki, additional, Yoshikawa, Tsutomu, additional, and Fukuda, Keiichi, additional

Published
2011
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26. Systemic Acidosis Predicts Malignant Ventricular Arrhythmias after Reperfusion Therapy for ST-Elevation Myocardial Infarction

Author

Nagai, Toshiyuki, primary, Anzai, Toshihisa, additional, Kaneko, Hidehiro, additional, Anzai, Atsushi, additional, Mano, Yoshinori, additional, Nagatomo, Yuji, additional, Kohsaka, Shun, additional, Maekawa, Yuichiro, additional, Yoshikawa, Tsutomu, additional, Ogawa, Satoshi, additional, and Fukuda, Keiichi, additional

Published
2010
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27. Impact of Systemic Acidosis on the Development of Malignant Ventricular Arrhythmias After Reperfusion Therapy for ST-Elevation Myocardial Infarction

Author

Nagai, Toshiyuki, primary, Anzai, Toshihisa, additional, Kaneko, Hidehiro, additional, Anzai, Atsushi, additional, Mano, Yoshinori, additional, Nagatomo, Yuji, additional, Kohsaka, Shun, additional, Maekawa, Yuichiro, additional, Kawamura, Akio, additional, Yoshikawa, Tsutomu, additional, and Ogawa, Satoshi, additional

Published
2010
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32. Aberrant Expression and Potency as a Cancer Immunotherapy Target of Inhibitor of Apoptosis Protein Family, Livin/ML-IAP in Lung Cancer

Author

Hariu, Hiroyuki, primary, Hirohashi, Yoshihiko, additional, Torigoe, Toshihiko, additional, Asanuma, Hiroko, additional, Hariu, Midori, additional, Tamura, Yasuaki, additional, Aketa, Katsuyuki, additional, Nabeta, Chika, additional, Nakanishi, Katsuya, additional, Kamiguchi, Kenjiro, additional, Mano, Yoshinori, additional, Kitamura, Hiroshi, additional, Kobayashi, Junichi, additional, Tsukahara, Tomohide, additional, Shijubo, Noriharu, additional, and Sato, Noriyuki, additional

Published
2005
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33. 989: Livin, an Inhibitor of Apoptosis Family Member is a Novel Target for Cancer Immunotherapy

Author

Kitamura, Hiroshi, primary, Torigoe, Toshihiko, additional, Hariu, Hiroyuki, additional, Aketa, Katsuyuki, additional, Tamura, Yasuaki, additional, Mano, Yoshinori, additional, Nabeta, Chika, additional, Nakanishi, Katsuya, additional, Asanuma, Hiroko, additional, Takahashi, Atsushi, additional, Itoh, Naoki, additional, Sato, Masaaki, additional, Sato, Noriyuki, additional, and Tsukamoto, Taiji, additional

Published
2004
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39. [Acute myeloid leukemia presenting with obstructive jaundice and granulocytic sarcoma of the common bile duct].

Author

Mano Y, Yokoyama K, Chen CK, Tsukada Y, Ikeda Y, and Okamoto S

Subjects
Humans, Male, Middle Aged, Common Bile Duct Neoplasms etiology, Jaundice, Obstructive etiology, Leukemia, Myeloid, Acute complications, Sarcoma, Myeloid etiology
Abstract

A 55-year-old man presented with jaundice and edema of the right leg. Tests of the peripheral blood and bone marrow showed leukocytopenia with 6% blasts and 38.3% of myeloperoxidase-positive blasts, respectively. Computed tomography (CT) scanning disclosed thickening of the common bile duct wall. Granulocytic sarcomas were also found at the left chest wall and the pelvic floor. Endoscopic retrograde cholangiopancreatography confirmed the narrowing of the common bile duct. Biopsy specimens of the common bile duct and pelvic masses revealed myeloblastic infiltration. After placement of a naso-biliary drainage tube, chemotherapy consisting of cytarabine (100 mg/m2/ day for 7 days) and idarubicin (12 mg/m2/ day for 3 days) was commenced. The dose of idarubicin was not modified. No serious complications, including delayed hematopoietic recovery, were observed after chemotherapy, and a complete remission was obtained 35 days later. Jaundice and liver dysfunction also gradually improved. The patient continues to receive consolidation therapy and remains in remission 8 months after the onset of his illness.

Published
2004

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