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642 results on '"Manne, Upender"'

1. Combination of dual JAK/HDAC inhibitor with regorafenib synergistically reduces tumor growth, metastasis, and regorafenib-induced toxicity in colorectal cancer

Author

Bajpai, Prachi, Agarwal, Sumit, Afaq, Farrukh, Al Diffalha, Sameer, Chandrashekar, Darshan S., Kim, Hyung-Gyoon, Shelton, Abigail, Miller, C. Ryan, Singh, Santosh K., Singh, Rajesh, Varambally, Sooryanarayana, Nagaraju, Ganji Purnachandra, Manne, Ashish, Paluri, Ravi, Khushman, Moh’d, and Manne, Upender

Published
2024
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4. PBRM1 mutations might render a subtype of biliary tract cancers sensitive to drugs targeting the DNA damage repair system

Author

Zimmer, Kai, Kocher, Florian, Untergasser, Gerold, Kircher, Brigitte, Amann, Arno, Baca, Yasmine, Xiu, Joanne, Korn, W. Micheal, Berger, Martin D., Lenz, Heinz-Josef, Puccini, Alberto, Fontana, Elisa, Shields, Anthony F., Marshall, John L., Hall, Michael, El-Deiry, Wafik S., Hsiehchen, David, Macarulla, Teresa, Tabernero, Josep, Pichler, Renate, Khushman, Moh’d, Manne, Upender, Lou, Emil, Wolf, Dominik, Sokolova, Viktorija, Schnaiter, Simon, Zeimet, Alain G., Gulhati, Pat, Widmann, Gerlig, and Seeber, Andreas

Published
2023
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7. Microbiome diversity in African American, European American, and Egyptian colorectal cancer patients

Author

Elkholy, Amr, Avuthu, Nagavardhini, Abdalla, Mohammed, Behring, Michael, Bajpai, Prachi, Kim, Hyung-Gyoon, Header, Doaa, Abo Elwafa, Reham AH., Saed, Hesham, Embaby, Amira, El-Nikhely, Nefertiti, Obuya, Sarah, Mohamed, Mostafa, Badawy, Ahmed Ashour, Nawar, Ahmed, Afaq, Farrukh, Rogers, Laura Q., Bae, Sejong, Shikany, James M., Bateman, Lori Brand, Fouad, Mona, Saleh, Mansoor, Samuel, Temesgen, Varambally, Sooryanarayana, Guda, Chittibabu, Arafat, Waleed, and Manne, Upender

Published
2023
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9. A potent and selective pan-RAS inhibitor, ADT-1004, targeting complex KRAS mutations for pancreatic cancer.

Author

Piazza, Gary A., primary, Bandi, Reddy D. S., additional, Ganji, Pumachandra N., additional, Foote, Jeremy B., additional, Keeton, Adam B., additional, Mattox, Tyler Ernest, additional, Chen, Xi, additional, Hardy, Cherlene, additional, Berry, Kristy, additional, Maxuitenko, Yulia, additional, Manne, Upender, additional, Boyd, Michael R., additional, Buchsbaum, Donald J., additional, and El-Rayes, Bassel F., additional

Published
2024
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10. Evaluation of a novel Pan-RAS/β-Catenin inhibitor, ADT-030, for treatment of pancreatic cancer.

Author

Piazza, Gary A, primary, Bandi, Reddy DS, additional, Ganji, Pumachandra N, additional, Foote, Jeremy B, additional, Keeton, Adam B, additional, Mattox, Tyler Ernest, additional, Chen, Xi, additional, Hardy, Cherlene, additional, Berry, Kristy, additional, Maxuitenko, Yulia, additional, Manne, Upender, additional, Buchsbaum, Donald J, additional, El-Rayes, Bassel F., additional, and Boyd, Michael R, additional

Published
2024
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13. Mature MUC5AC Expression in Resected Pancreatic Ductal Adenocarcinoma Predicts Treatment Response and Outcomes.

Author

Manne, Ashish, Esnakula, Ashwini, Sheel, Ankur, Sara, Amir, Manne, Upender, Paluri, Ravi Kumar, He, Kai, Yang, Wancai, Sohal, Davendra, Kasi, Anup, Noonan, Anne M., Mittra, Arjun, Hays, John, Roychowdhury, Sameek, Malalur, Pannaga, Rahman, Shafia, Jin, Ning, Cloyd, Jordan M., Tsai, Susan, and Ejaz, Aslam

Subjects
PANCREATIC duct, NEOADJUVANT chemotherapy, OVERALL survival, PROGRESSION-free survival, PANCREATIC cancer
Abstract

Neoadjuvant therapy (NAT) for early-stage pancreatic ductal adenocarcinoma (PDA) has recently gained prominence. We investigated the clinical significance of mucin 5 AC (MUC5AC), which exists in two major glycoforms, a less-glycosylated immature isoform (IM) and a heavily glycosylated mature isoform (MM), as a biomarker in resected PDA. Immunohistochemistry was performed on 100 resected PDAs to evaluate the expression of the IM and MM of MUC5AC using their respective monoclonal antibodies, CLH2 (NBP2-44455) and 45M1 (ab3649). MUC5AC localization (cytoplasmic, apical, and extra-cellular (EC)) was determined, and the H-scores were calculated. Univariate and multivariate (MVA) Cox regression models were used to estimate progression-free survival (PFS) and overall survival (OS). Of 100 resected PDA patients, 43 received NAT, and 57 were treatment-naïve with upfront surgery (UpS). In the study population (n = 100), IM expression (H-scores for objective response vs. no response vs. UpS = 104 vs. 152 vs. 163, p = 0.01) and MM-MUC5AC detection rates (56% vs. 63% vs. 82%, p = 0.02) were significantly different. In the NAT group, MM-MUC5AC-negative patients had significantly better PFS according to the MVA (Hazard Ratio: 0.2, 95% CI: 0.059–0.766, p = 0.01). Similar results were noted in a FOLFIRINOX sub-group (n = 36). We established an association of MUC5AC expression with treatment response and outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Molecular characterization of visible low-grade dysplastic lesions in patients with inflammatory bowel disease

Author

Dhall, Deepti, primary, Makhoul, Elias, additional, Taguibao, Roberto, additional, Waters, Kevin, additional, Zhang, Wenjuan, additional, Vail, Eric, additional, Lee, Goo, additional, Diffalha, Sameer Al., additional, Patel, Chirag, additional, Manne, Upender, additional, Behring, Michael, additional, Chopra, Shefali, additional, and Harada, Shuko, additional

Published
2023
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22. Supplementary Figure 6 from BZW2 Inhibition Reduces Colorectal Cancer Growth and Metastasis

Author

Agarwal, Sumit, primary, Afaq, Farrukh, primary, Bajpai, Prachi, primary, Behring, Michael, primary, Kim, Hyung-Gyoon, primary, Varambally, Amith, primary, Chandrashekar, Darshan S., primary, Peter, Shajan, primary, Diffalha, Sameer Al, primary, Khushman, Moh'd, primary, Seeber, Andreas, primary, Varambally, Sooryanarayana, primary, and Manne, Upender, primary

Published
2023
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23. Supplementary Figure 7 from BZW2 Inhibition Reduces Colorectal Cancer Growth and Metastasis

Author

Agarwal, Sumit, primary, Afaq, Farrukh, primary, Bajpai, Prachi, primary, Behring, Michael, primary, Kim, Hyung-Gyoon, primary, Varambally, Amith, primary, Chandrashekar, Darshan S., primary, Peter, Shajan, primary, Diffalha, Sameer Al, primary, Khushman, Moh'd, primary, Seeber, Andreas, primary, Varambally, Sooryanarayana, primary, and Manne, Upender, primary

Published
2023
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24. Supplementary Figure 1 from BZW2 Inhibition Reduces Colorectal Cancer Growth and Metastasis

Author

Agarwal, Sumit, primary, Afaq, Farrukh, primary, Bajpai, Prachi, primary, Behring, Michael, primary, Kim, Hyung-Gyoon, primary, Varambally, Amith, primary, Chandrashekar, Darshan S., primary, Peter, Shajan, primary, Diffalha, Sameer Al, primary, Khushman, Moh'd, primary, Seeber, Andreas, primary, Varambally, Sooryanarayana, primary, and Manne, Upender, primary

Published
2023
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25. Supplementary Figure 5 from BZW2 Inhibition Reduces Colorectal Cancer Growth and Metastasis

Author

Agarwal, Sumit, primary, Afaq, Farrukh, primary, Bajpai, Prachi, primary, Behring, Michael, primary, Kim, Hyung-Gyoon, primary, Varambally, Amith, primary, Chandrashekar, Darshan S., primary, Peter, Shajan, primary, Diffalha, Sameer Al, primary, Khushman, Moh'd, primary, Seeber, Andreas, primary, Varambally, Sooryanarayana, primary, and Manne, Upender, primary

Published
2023
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26. Supplementary Figure 4 from BZW2 Inhibition Reduces Colorectal Cancer Growth and Metastasis

Author

Agarwal, Sumit, primary, Afaq, Farrukh, primary, Bajpai, Prachi, primary, Behring, Michael, primary, Kim, Hyung-Gyoon, primary, Varambally, Amith, primary, Chandrashekar, Darshan S., primary, Peter, Shajan, primary, Diffalha, Sameer Al, primary, Khushman, Moh'd, primary, Seeber, Andreas, primary, Varambally, Sooryanarayana, primary, and Manne, Upender, primary

Published
2023
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27. Supplementary Figure 8 from BZW2 Inhibition Reduces Colorectal Cancer Growth and Metastasis

Author

Agarwal, Sumit, primary, Afaq, Farrukh, primary, Bajpai, Prachi, primary, Behring, Michael, primary, Kim, Hyung-Gyoon, primary, Varambally, Amith, primary, Chandrashekar, Darshan S., primary, Peter, Shajan, primary, Diffalha, Sameer Al, primary, Khushman, Moh'd, primary, Seeber, Andreas, primary, Varambally, Sooryanarayana, primary, and Manne, Upender, primary

Published
2023
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28. Supplementary Data from BZW2 Inhibition Reduces Colorectal Cancer Growth and Metastasis

Author

Agarwal, Sumit, primary, Afaq, Farrukh, primary, Bajpai, Prachi, primary, Behring, Michael, primary, Kim, Hyung-Gyoon, primary, Varambally, Amith, primary, Chandrashekar, Darshan S., primary, Peter, Shajan, primary, Diffalha, Sameer Al, primary, Khushman, Moh'd, primary, Seeber, Andreas, primary, Varambally, Sooryanarayana, primary, and Manne, Upender, primary

Published
2023
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29. Supplementary Figure 3 from BZW2 Inhibition Reduces Colorectal Cancer Growth and Metastasis

Author

Agarwal, Sumit, primary, Afaq, Farrukh, primary, Bajpai, Prachi, primary, Behring, Michael, primary, Kim, Hyung-Gyoon, primary, Varambally, Amith, primary, Chandrashekar, Darshan S., primary, Peter, Shajan, primary, Diffalha, Sameer Al, primary, Khushman, Moh'd, primary, Seeber, Andreas, primary, Varambally, Sooryanarayana, primary, and Manne, Upender, primary

Published
2023
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30. Supplementary Figure 2 from BZW2 Inhibition Reduces Colorectal Cancer Growth and Metastasis

Author

Agarwal, Sumit, primary, Afaq, Farrukh, primary, Bajpai, Prachi, primary, Behring, Michael, primary, Kim, Hyung-Gyoon, primary, Varambally, Amith, primary, Chandrashekar, Darshan S., primary, Peter, Shajan, primary, Diffalha, Sameer Al, primary, Khushman, Moh'd, primary, Seeber, Andreas, primary, Varambally, Sooryanarayana, primary, and Manne, Upender, primary

Published
2023
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31. BZW2 Inhibition Reduces Colorectal Cancer Growth and Metastasis

Author

Agarwal, Sumit, primary, Afaq, Farrukh, additional, Bajpai, Prachi, additional, Behring, Michael, additional, Kim, Hyung-Gyoon, additional, Varambally, Amith, additional, Chandrashekar, Darshan S., additional, Peter, Shajan, additional, Diffalha, Sameer Al, additional, Khushman, Moh'd, additional, Seeber, Andreas, additional, Varambally, Sooryanarayana, additional, and Manne, Upender, additional

Published
2023
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32. Data from BZW2 Inhibition Reduces Colorectal Cancer Growth and Metastasis

Author

Agarwal, Sumit, primary, Afaq, Farrukh, primary, Bajpai, Prachi, primary, Behring, Michael, primary, Kim, Hyung-Gyoon, primary, Varambally, Amith, primary, Chandrashekar, Darshan S., primary, Peter, Shajan, primary, Diffalha, Sameer Al, primary, Khushman, Moh'd, primary, Seeber, Andreas, primary, Varambally, Sooryanarayana, primary, and Manne, Upender, primary

Published
2023
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33. Data from African Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent

Author

Martini, Rachel, primary, Delpe, Princesca, primary, Chu, Timothy R., primary, Arora, Kanika, primary, Lord, Brittany, primary, Verma, Akanksha, primary, Bedi, Deepa, primary, Karanam, Balasubramanyam, primary, Elhussin, Isra, primary, Chen, Yalei, primary, Gebregzabher, Endale, primary, Oppong, Joseph K., primary, Adjei, Ernest K., primary, Jibril Suleiman, Aisha, primary, Awuah, Baffour, primary, Muleta, Mahteme Bekele, primary, Abebe, Engida, primary, Kyei, Ishmael, primary, Aitpillah, Frances S., primary, Adinku, Michael O., primary, Ankomah, Kwasi, primary, Osei-Bonsu, Ernest Baawuah, primary, Chitale, Dhananjay A., primary, Bensenhaver, Jessica M., primary, Nathanson, David S., primary, Jackson, LaToya, primary, Petersen, Lindsay F., primary, Proctor, Erica, primary, Stonaker, Brian, primary, Gyan, Kofi K., primary, Gibbs, Lee D., primary, Monojlovic, Zarko, primary, Kittles, Rick A., primary, White, Jason, primary, Yates, Clayton C., primary, Manne, Upender, primary, Gardner, Kevin, primary, Mongan, Nigel, primary, Cheng, Esther, primary, Ginter, Paula, primary, Hoda, Syed, primary, Elemento, Olivier, primary, Robine, Nicolas, primary, Sboner, Andrea, primary, Carpten, John D., primary, Newman, Lisa, primary, and Davis, Melissa B., primary

Published
2023
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35. Supplementary Table from African Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent

Author

Martini, Rachel, primary, Delpe, Princesca, primary, Chu, Timothy R., primary, Arora, Kanika, primary, Lord, Brittany, primary, Verma, Akanksha, primary, Bedi, Deepa, primary, Karanam, Balasubramanyam, primary, Elhussin, Isra, primary, Chen, Yalei, primary, Gebregzabher, Endale, primary, Oppong, Joseph K., primary, Adjei, Ernest K., primary, Jibril Suleiman, Aisha, primary, Awuah, Baffour, primary, Muleta, Mahteme Bekele, primary, Abebe, Engida, primary, Kyei, Ishmael, primary, Aitpillah, Frances S., primary, Adinku, Michael O., primary, Ankomah, Kwasi, primary, Osei-Bonsu, Ernest Baawuah, primary, Chitale, Dhananjay A., primary, Bensenhaver, Jessica M., primary, Nathanson, David S., primary, Jackson, LaToya, primary, Petersen, Lindsay F., primary, Proctor, Erica, primary, Stonaker, Brian, primary, Gyan, Kofi K., primary, Gibbs, Lee D., primary, Monojlovic, Zarko, primary, Kittles, Rick A., primary, White, Jason, primary, Yates, Clayton C., primary, Manne, Upender, primary, Gardner, Kevin, primary, Mongan, Nigel, primary, Cheng, Esther, primary, Ginter, Paula, primary, Hoda, Syed, primary, Elemento, Olivier, primary, Robine, Nicolas, primary, Sboner, Andrea, primary, Carpten, John D., primary, Newman, Lisa, primary, and Davis, Melissa B., primary

Published
2023
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36. Supplementary Data from African Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent

Author

Martini, Rachel, primary, Delpe, Princesca, primary, Chu, Timothy R., primary, Arora, Kanika, primary, Lord, Brittany, primary, Verma, Akanksha, primary, Bedi, Deepa, primary, Karanam, Balasubramanyam, primary, Elhussin, Isra, primary, Chen, Yalei, primary, Gebregzabher, Endale, primary, Oppong, Joseph K., primary, Adjei, Ernest K., primary, Jibril Suleiman, Aisha, primary, Awuah, Baffour, primary, Muleta, Mahteme Bekele, primary, Abebe, Engida, primary, Kyei, Ishmael, primary, Aitpillah, Frances S., primary, Adinku, Michael O., primary, Ankomah, Kwasi, primary, Osei-Bonsu, Ernest Baawuah, primary, Chitale, Dhananjay A., primary, Bensenhaver, Jessica M., primary, Nathanson, David S., primary, Jackson, LaToya, primary, Petersen, Lindsay F., primary, Proctor, Erica, primary, Stonaker, Brian, primary, Gyan, Kofi K., primary, Gibbs, Lee D., primary, Monojlovic, Zarko, primary, Kittles, Rick A., primary, White, Jason, primary, Yates, Clayton C., primary, Manne, Upender, primary, Gardner, Kevin, primary, Mongan, Nigel, primary, Cheng, Esther, primary, Ginter, Paula, primary, Hoda, Syed, primary, Elemento, Olivier, primary, Robine, Nicolas, primary, Sboner, Andrea, primary, Carpten, John D., primary, Newman, Lisa, primary, and Davis, Melissa B., primary

Published
2023
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37. Abstract 1003: The prognostic significance of prolyl 4-hydroxylase subunit alpha 1 and the therapeutic efficacy of diethyl-pythiDC, its small molecule inhibitor, in pancreatic ductal adenocarcinoma

Author

Khushman, Moh'd, primary, Afaq, Farrukh, additional, Bajpai, Prachi, additional, Diffalha, Sameer Al, additional, Outlaw, Darryl, additional, Williams, Grant R., additional, Jacob, Rojymon, additional, Kabir, Kondal Rao Kyanam, additional, Ahmed, Ali, additional, Shajan, Peter, additional, Varambally, Sooryanarayana, additional, and Manne, Upender, additional

Published
2023
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38. Supplementary Figure from African Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent

Author

Martini, Rachel, primary, Delpe, Princesca, primary, Chu, Timothy R., primary, Arora, Kanika, primary, Lord, Brittany, primary, Verma, Akanksha, primary, Bedi, Deepa, primary, Karanam, Balasubramanyam, primary, Elhussin, Isra, primary, Chen, Yalei, primary, Gebregzabher, Endale, primary, Oppong, Joseph K., primary, Adjei, Ernest K., primary, Jibril Suleiman, Aisha, primary, Awuah, Baffour, primary, Muleta, Mahteme Bekele, primary, Abebe, Engida, primary, Kyei, Ishmael, primary, Aitpillah, Frances S., primary, Adinku, Michael O., primary, Ankomah, Kwasi, primary, Osei-Bonsu, Ernest Baawuah, primary, Chitale, Dhananjay A., primary, Bensenhaver, Jessica M., primary, Nathanson, David S., primary, Jackson, LaToya, primary, Petersen, Lindsay F., primary, Proctor, Erica, primary, Stonaker, Brian, primary, Gyan, Kofi K., primary, Gibbs, Lee D., primary, Monojlovic, Zarko, primary, Kittles, Rick A., primary, White, Jason, primary, Yates, Clayton C., primary, Manne, Upender, primary, Gardner, Kevin, primary, Mongan, Nigel, primary, Cheng, Esther, primary, Ginter, Paula, primary, Hoda, Syed, primary, Elemento, Olivier, primary, Robine, Nicolas, primary, Sboner, Andrea, primary, Carpten, John D., primary, Newman, Lisa, primary, and Davis, Melissa B., primary

Published
2023
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39. Abstract 6586: Updates to UALCAN, a comprehensive cancer proteogenomic data analysis platform for discovery research

Author

Chandrashekar, Darshan Shimoga, primary, Varambally, Sooryanarayana, additional, Karthikeyan, Santhosh Kumar, additional, Korla, Praveen Kumar, additional, Patel, Henalben, additional, Athar, Mohammad, additional, Manne, Upender, additional, Netto, George J., additional, Shovon, Ahmedur Rahman, additional, Kumar, Sidharth, additional, Qin, Zhaohui S., additional, and Crieghton, Chad J., additional

Published
2023
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40. Abstract 1297: BZW2 a potential target to inhibit colorectal cancer growth and metastasis

Author

Bajpai, Prachi, primary, Agarwal, Sumit, additional, Afaq, Farrukh, additional, Behring, Michael, additional, Kim, Hyung-Gyoon, additional, Chandrashekar, Darshan Shimoga, additional, Peter, Shajan, additional, Diffalha, Sameer Al, additional, Khushman, Moh’d, additional, Seeber, Andreas, additional, Varambally, Sooryanarayana, additional, and Manne, Upender, additional

Published
2023
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