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13. Polytraumaversorgung auf der Intensivstation

Author

Mann, V., Mann, S., Szalay, G., Hirschburger, M., Röhrig, R., Dictus, C., Wurmb, T., Weigand, M.A., and Bernhard, M.

Abstract

Zusammenfassung: Die intensivmedizinische Behandlung polytraumatisierter Patienten gehört zu den größten Herausforderungen der Medizin. Bereits im frühen Verlauf muss engmaschig eine suffiziente Reevaluation der klinischen und apparativen Befunde in einem geschulten interdisziplinären Team erfolgen („tertiary trauma survey“), um die teils deletären Folgen von in der Erstdiagnostik im Schockraum übersehenen Verletzungen („missed injuries“) zu verhindern. Während des im Mittel 11-tägigen Aufenthalts der Patienten auf der Intensivstation muss dann eine Therapiestrategie gewählt werden, die neben einer qualitativ hochwertigen allgemeinen Intensivmedizin insbesondere die Spezifika des individuell vorliegenden Verletzungsmusters berücksichtigt. Da sich bei schwer verletzten Patienten zunehmend das Konzept der „damage control surgery“ durchsetzt, ist die Intensivstation häufig Dreh- und Angelpunkt in der kritischen Zeit zwischen der operativen Erstversorgung und frühelektiven Eingriffen. Daher ist eine enge Abstimmung zwischen dem Intensivmediziner und den beteiligten operativen Disziplinen zum Erreichen des gemeinsamen Ziels aller therapeutischen Bemühungen unabdingbar: Der polytraumatisierte Patient soll nach Überleben der Akutphase rasch rehabilitiert und wieder ins Berufs- sowie Sozialleben eingegliedert werden können.

Published
2024
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14. ETS transcription factor ELF3 (ESE-1) is a cell cycle regulator in benign and malignant prostate

Author

Archer, L K, Frame, F M, Walker, H F, Droop, A P, McDonald, G L K, Kucko, S, Berney, D M, Mann, V M, Simms, M S, and Maitland, N J

Abstract

This study aimed to elucidate the role of ELF3, an ETS family member in normal prostate growth and prostate cancer. Silencing ELF3 in both benign prostate (BPH-1) and prostate cancer (PC3) cell lines resulted in decreased colony forming ability, inhibition of cell migration and reduced cell viability due to cell cycle arrest, establishing ELF3 as a cell cycle regulator. Increased ELF3 expression in more advanced prostate tumours was shown by immunostaining of tissue microarrays and from analysis of gene expression and genetic alteration studies. This study indicates that ELF3 functions as part of normal prostate epithelial growth but also as a potential oncogene in advanced prostate cancers.

Published
2022

43. Ein Kind mit Trisomie 18 und Stridor -- erwartet schwieriger Atemweg mit unerwartetem Befund.

Author

Zajonz, T. S., Rosenbaum, E., Langer, C., Hultsch, R., Sander, M., and Mann, V.

Abstract

Copyright of Anaesthesiologie & Intensivmedizin is the property of DGAI e.V. - Deutsche Gesellschaft fur Anasthesiologie und Intensivmedizin e.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2021
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47. Prähospitale Behandlung des akuten Koronarsyndroms unter DOAK-Dauertherapie

Author

Schneck, E., primary, Schneck, F. K., additional, Wolter, J. S., additional, Hamm, C. W., additional, Mann, V., additional, Hauch, H., additional, Kemkes-Matthes, B., additional, Gräsner, J. T., additional, Groesdonk, H. V., additional, Dirkmann, D., additional, Sander, M., additional, Koch, C., additional, and Brenck, F., additional

Published
2019
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48. Low-temperature plasma treatment induces DNA damage leading to necrotic cell death in primary prostate epithelial cells

Author

Hirst, A M, Simms, M S, Mann, V M, Maitland, N J, O'Connell, D, and Frame, F M

Subjects
Male, Plasma Gases, Blotting, Western, Prostate, Prostatic Neoplasms, Apoptosis, Epithelial Cells, Hydrogen Peroxide, prostate cancer, necrosis, Cold Temperature, Autophagy, Humans, low-temperature plasma, primary epithelial cells, reactive species, Molecular Diagnostics, Cells, Cultured, DNA Damage
Abstract

Background: In recent years, the rapidly advancing field of low-temperature atmospheric pressure plasmas has shown considerable promise for future translational biomedical applications, including cancer therapy, through the generation of reactive oxygen and nitrogen species. Method: The cytopathic effect of low-temperature plasma was first verified in two commonly used prostate cell lines: BPH-1 and PC-3 cells. The study was then extended to analyse the effects in paired normal and tumour (Gleason grade 7) prostate epithelial cells cultured directly from patient tissue. Hydrogen peroxide (H2O2) and staurosporine were used as controls throughout. Results: Low-temperature plasma (LTP) exposure resulted in high levels of DNA damage, a reduction in cell viability, and colony-forming ability. H2O2 formed in the culture medium was a likely facilitator of these effects. Necrosis and autophagy were recorded in primary cells, whereas cell lines exhibited apoptosis and necrosis. Conclusions: This study demonstrates that LTP treatment causes cytotoxic insult in primary prostate cells, leading to rapid necrotic cell death. It also highlights the need to study primary cultures in order to gain more realistic insight into patient response.

Published
2015

50. Development of Voice Recognition: Parallels with Face Recognition.

Author

Mann, V. A.

Abstract

Describes the development of the capacity of encoding unfamiliar voices and compares this development with the development of the capacity for encoding faces. Subjects were 20 students from Massachusetts Institute of Technology, and 20 children aged 6 to 16. (MP)

Published
1979

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