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This case report presents the surgical management of a fibroadenoma in the left breast of a Nineteen-year-old female. The patient was exposed with the complaint of a palpable lump in her left breast, prompting further investigations. Ultrasonography revealed the presence of a lesion consistent with fibroadenoma. Subsequently, the patient underwent surgical excision of the lesion to alleviate discomfort and address diagnostic concerns. The procedure involved a Circumareolar incision followed by meticulous dissection and excision of the fibroadenoma lump. Postoperative evaluation confirmed successful removal of the lesion with resolution of associated symptoms. This case uplifts the importance of prompt diagnosis and appropriate management of benign breast masses in young patients to alleviate anxiety and ensure optimal positive outcomes. [ABSTRACT FROM AUTHOR]

Background and Objectives: Doxorubicin hydrochloride (DOX-HCl), a potent and extensively utilized anticancer medication, faces limitations in skin penetration, resulting in confined effectiveness. Frequent administration leads to resistance at the site of application. This study aims to strike a balance between precision and selectivity to enhance DOX-HCl's permeation. The goal is to achieve non-invasive drug delivery that avoids issues linked with conventional therapies. This will be achieved through the utilization of patches loaded with transfersomes for drug delivery. Materials and Methods: Transferosomes were prepared through the rotary evaporation technique and optimized by Box-Behnken experimental design. The impact of phospholipid, cholesterol, and tween-80 on drug entrapment efficiency and particle size was assessed using analysis of variance. The resulting formulations underwent characterization involving particle size, zeta potential, transmission electron microscopy, and Fourier-transform infrared spectroscopy. In addition, drug entrapment efficiency, in vitro drug release patterns, ex vivo drug permeation profiles, and histopathological evaluations of the optimized formulations were conducted. Results: The particle size ranged from 53 to 168 nm, with drug entrapment efficiency ranging from 30.8 ± 0.06 to 87.90 ± 0.02%. The optimum formulation exhibited a zeta potential of -24.9 mV and achieved an approximately fourfold increase in permeation rate compared to a pure drug suspension. Histopathological studies of rat abdominal skin samples post-treatment with transferosomes patch indicate a moderate epidermal inflammation versus normal morphology for untreated skin. Conclusion: Utilizing transferosomes in transdermal drug delivery systems (TDDS) presents a promising strategy to address challenges associated with conventional therapies. By incorporating transferosomes into patches, this approach offers a multi-faceted solution to enhance non-invasive drug delivery. [ABSTRACT FROM AUTHOR]