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19. Fabrication of binary to quaternary PVDF based flexible composite films and ultrathin sandwich structured quaternary PVDF/CB/g-C3N4/BaFe11.5Al0.5O19 composite films for efficient EMI shielding performance

Author

Anand, S., primary, Muniyappan, S., additional, Racik, K. Mohamed, additional, Manikandan, A., additional, Mani, Dineshkumar, additional, Nandhini, S., additional, Karuppasamy, P., additional, Pandian, Muthu Senthil, additional, Ramasamy, P., additional, and Chandar, N. Krishna, additional

Published
2022
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21. Insitu Opthalmic Drug Delivery Systems

Author

Vyshnavi Tallapaneni, Mani Dineshkumar, and Veera Venkata Satyanarayana Reddy Karri

Subjects
Drug, genetic structures, Contact time, business.industry, media_common.quotation_subject, BIO-AVAILABILITY, Bio compatibility, eye diseases, Drug activity, Drug delivery, Gel preparation, Medicine, sense organs, General Pharmacology, Toxicology and Pharmaceutics, business, Site of action, Biomedical engineering, media_common
Abstract

Eyes are considered as one of the most important organs of the body. The main hurdle for achieving effective ocular treatment is the maintenance of adequate quantity of drug at the site of action within the eye. Maintaining the concentration of drug in the eye is a difficult task as the anatomy and physiology of the eye leads to the draining of the drug from the eye. This leads to poor ocular bio availability and there by poor ocular therapy. The ocular bio availability can be improved by increasing the ocular retention time of the formulation. Insitu gel formation technology is a promising technique to prevent the lacrimal drainage of the drug rapidly from the eyes. Insitu gel preparation will be in liquid from when prepared, they are administered into the Cul-de-sac of the eye. Due to the environmental characteristics of the eye such as temperature, pH, Ionic concentration etc. the liquid formulation changes to gel form. This will increase the residence time and contact time of the drug with the mucosa of the eye. Insitu gels can increase the ocular bioavailability of the drug .The primary requirement of a successful control release product focuses on increasing patient compliance, good stability and bio compatibility. Insitu gels are used now a days as vehicles for both local and systemic drug therapies. This review deals with the study of a novel insitu gel approaches as a means to localize and prolong drug activity at its site of action.

Published
2020
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