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2. Major hepatectomy for perihilar cholangiocarcinoma in elderly patients: is it reasonable?

Author

Ripamonti, L, De Carlis, R, Lauterio, A, Mangoni, I, Frassoni, S, Bagnardi, V, Centonze, L, Poli, C, Buscemi, V, Ferla, F, De Carlis, L, Ripamonti L., De Carlis R., Lauterio A., Mangoni I., Frassoni S., Bagnardi V., Centonze L., Poli C., Buscemi V., Ferla F., De Carlis L., Ripamonti, L, De Carlis, R, Lauterio, A, Mangoni, I, Frassoni, S, Bagnardi, V, Centonze, L, Poli, C, Buscemi, V, Ferla, F, De Carlis, L, Ripamonti L., De Carlis R., Lauterio A., Mangoni I., Frassoni S., Bagnardi V., Centonze L., Poli C., Buscemi V., Ferla F., and De Carlis L.

Abstract

Introduction: We sought to evaluate the effect of age on postoperative outcomes among patients undergoing major liver surgery for perihilar cholangiocarcinoma (PHCC). Methods: 77 patients were included. Patients were categorized into two groups: the “< 70-year-olds” group (n = 54) and the “≥ 70-year-olds” group (n = 23). Results: Median LOS was 19 both for < 70-year-old group and ≥ 70-year-old group (P = 0.72). No differences in terms of severe complication were detected (44.4% Clavien–Dindo 3–4–5 in < 70-year-old group vs 47.8% in ≥ 70-year-old group, P = 0.60). Within 90 postoperative days, 11 patients died, 6 in < 70-year-old group (11.3%) and 5 in ≥ 70-year-old group (21.7%), P = 0.29. The median follow‐up was 20 months. The death rate was 72.2% and 78.3% among patients < 70 years old and ≥ 70 years old. The OS at 2 and 5 years was significantly higher among the < 70 years old (57.0% and 27.7%) compared to the ≥ 70 years old (27.1% and 13.6%), P = 0.043. Adjusting for hypertension and Charlson comorbidity index in a multivariate analysis, the HR for age was 1.93 (95% CI 0.84–4.44), P = 0.12. Relapse occurred in 43 (81.1%) patients in the < 70-year-old group and in 19 (82.6%) patients in the ≥ 70-year-old group. DFS at 12, 24, and 36 months was, respectively, 59.6, 34.2, and 23.2 for the < 70 -year-old group and 32.5, 20.3, and 13.5 for the ≥ 70-year-old group (P = 0.26). Adjusting for hypertension and Charlson comorbidity index in a Cox model, the HR for age was 1.52 (95% CI 0.67–3.46), with P = 0.32. Conclusions: ≥ 70-year-old patients with PHCC can still be eligible for major liver resection with acceptable complication rates and should not be precluded a priori from a radical treatment.

Published
2022

5. Very Early Introduction of Everolimus in De Novo Liver Transplantation: Results of a Multicenter, Prospective, Randomized Trial

Author

Cillo, U, Saracino, L, Vitale, A, Bertacco, A, Salizzoni, M, Lupo, F, Colledan, M, Corno, V, Rossi, G, Reggiani, P, Baccarani, U, Bresadola, V, De Carlis, L, Mangoni, I, Ramirez Morales, R, Agnes, S, Nure, E, Cillo U., Saracino L., Vitale A., Bertacco A., Salizzoni M., Lupo F., Colledan M., Corno V., Rossi G., Reggiani P., Baccarani U., Bresadola V., De Carlis L., Mangoni I., Ramirez Morales R., Agnes S., Nure E., Cillo, U, Saracino, L, Vitale, A, Bertacco, A, Salizzoni, M, Lupo, F, Colledan, M, Corno, V, Rossi, G, Reggiani, P, Baccarani, U, Bresadola, V, De Carlis, L, Mangoni, I, Ramirez Morales, R, Agnes, S, Nure, E, Cillo U., Saracino L., Vitale A., Bertacco A., Salizzoni M., Lupo F., Colledan M., Corno V., Rossi G., Reggiani P., Baccarani U., Bresadola V., De Carlis L., Mangoni I., Ramirez Morales R., Agnes S., and Nure E.

Abstract

Early everolimus (EVR) introduction and tacrolimus (TAC) minimization after liver transplantation may represent a novel immunosuppressant approach. This phase 2, multicenter, randomized, open-label trial evaluated the safety and efficacy of early EVR initiation. Patients treated with corticosteroids, TAC, and basiliximab were randomized (2:1) to receive EVR (1.5 mg twice daily) on day 8 and to gradually minimize or withdraw TAC when EVR was stable at >5 ng/mL or to continue TAC at 6-12 ng/mL. The primary endpoint was the proportion of treated biopsy-proven acute rejection (tBPAR)–free patients at 3 months after transplant. As secondary endpoints, composite tBPAR plus graft/patient loss rate, renal function, TAC discontinuation rate, and adverse events were assessed. A total of 93 patients were treated with EVR, and 47 were controls. After 3 months from transplantation, 87.1% of patients with EVR and 95.7% of controls were tBPAR-free (P = 0.09); composite endpoint-free patients with EVR were 85% (versus 94%; P = 0.15). Also at 3 months, 37.6% patients were in monotherapy with EVR, and the tBPAR rate was 11.4%. Estimated glomerular filtration rate was significantly higher with EVR, as early as 2 weeks after randomization. In the study group, higher rates of dyslipidemia (15% versus 6.4%), wound complication (18.32% versus 0%), and incisional hernia (25.8% versus 6.4%) were observed, whereas neurological disorders were more frequent in the control group (13.9% versus 31.9%; P < 0.05). In conclusion, an early EVR introduction and TAC minimization may represent a suitable approach when immediate preservation of renal function is crucial.

Published
2019

11. Successful Pre- and Posttransplant Sofosbuvir-Based Anti-Hepatitis C Virus Treatment in Persons Living With Human Immunodeficiency Virus Infection

Author

Guaraldi G, Rossotti R, Verucchi G, Tavio M, Pasulo L, Beghetto B, Dolci G, Nardini G, Badia L, Magliano A, Moioli MC, Puoti M, Travi G, Pazzi A, De Carlis L, Giacomoni A, Lauterio A, Mangoni I, Di Sandro S, Ferla F, Fagiuoli S, Colledan M, Cologni G, Di Benedetto F, Tarantino G, Serra V, Dolci G., Guaraldi G, Rossotti R, Verucchi G, Tavio M, Pasulo L, Beghetto B, Dolci G, Nardini G, Badia L, Magliano A, Moioli MC, Puoti M, Travi G, Pazzi A, De Carlis L, Giacomoni A, Lauterio A, Mangoni I, Di Sandro S, Ferla F, Fagiuoli S, Colledan M, Cologni G, Di Benedetto F, Tarantino G, Serra V, Dolci G., Guaraldi, G, Rossotti, R, Verucchi, G, Tavio, M, Pasulo, L, Beghetto, B, Dolci, G, Nardini, G, Badia, L, Magliano, A, Moioli, M, Puoti, M, Travi, G, Pazzi, A, De Carlis, L, Giacomoni, A, Lauterio, A, Mangoni, I, Di Sandro, S, Ferla, F, Fagiuoli, S, Colledan, M, Cologni, G, Di Benedetto, F, Tarantino, G, and Serra, V

Subjects
Sofosbuvir, medicine.medical_treatment, Hepatitis C virus, Human immunodeficiency virus (HIV), sofosbuvir, Anti hepatitis c virus, 030230 surgery, Liver transplantation, medicine.disease_cause, THERAPY, DISEASE, Virus, 03 medical and health sciences, 0302 clinical medicine, medicine, Hepatitis, NS5A inhibitor, HCV, HIV, NS5A inhibitors, liver transplantation, business.industry, Brief Report, Retrospective cohort study, sofosbuvir KeyWords Plus:COINFECTED LIVER-TRANSPLANT, medicine.disease, Author Keywords:HCV, Virology, RECIPIENTS, Infectious Diseases, Oncology, 030211 gastroenterology & hepatology, Neurology (clinical), RIBAVIRIN, business, medicine.drug
Abstract

This retrospective study reports the data of sofosbuvir-based anti-hepatitis C virus treatment in 24 candidates and 24 recipients of liver transplantation coinfected with human immunodeficiency virus. Sustained virologic response was cumulatively 85% (90% and 100% in those treated with optimal schedules pre- and posttransplant, respectively).

Published
2017

13. The UN-SUSTAINABLE Match in HCV Recipients. Evidences from the Italian D-MELD Study on Balancing Donor-Recipient Risk Factors.: Abstract# O-162

Author

Avolio, A. W., Agnes, S., Lirosi, M., Salizzoni, M., Pinna, A., Gridelli, B., De Carlis, L., Colledan, M., Gerunda, G., Rossi, G., Ettorre, G., Risaliti, A., Mazzaferro, V., Rossi, M., Tisone, G., Zamboni, F., Lupo, L., Cuomo, O., Calise, F., Donataccio, M., Nicolotti, N., Romagnoli, R., Vitale, A., Cucchetti, A., Gruttadauria, S., Baccarani, U., Caccamo, L., Mangoni, I., Pinelli, D., Montalti, R., Morelli, N., Vennarecci, G., Nicolini, D., Regalia, E., Lai, Q., Anselmo, A., Tondolo, E., Perrella, A., Burra, P., and Cillo, U.

Published
2012

14. Behind D-MELD: The Role of Primary Indication (HCV or HBV) as Significant Covariate in the Outcome Prediction after Liver Transplants.: Abstract# 1672: Poster Board #-Session: P234-IV

Author

Avolio, A. W., Agnes, S., Lirosi, M. C., Salizzoni, M., Pinna, A., Gridelli, B., De Carlis, L., Colledan, M., Gerunda, G., Valente, U., Rossi, G., Ettorre, G., Risaliti, A., Mazzaferro, V., Rossi, M., Tisone, G., Zamboni, F., Lupo, L., Cuomo, O., Calise, F., Nicolotti, N., Vitale, A., Romagnoli, R., Cucchetti, A., Gruttadauria, S., Mangoni, I., Pinelli, D., Montalti, R., Gelli, M., Caccamo, L., Vennarecci, G., Nicolini, D., Regalia, E., Baccarani, U., Lai, Q., Manzia, T., Tondolo, E., Rendina, M., Perrella, A., Scuderi, E., Burra, P., Gasbarrini, A., and Cillo, U.

Published
2012

15. www.D-MELD.com. THE ONLINE PROGNOSTIC CALCULATOR TO OPTIMIZE DONOR-RECIPIENT MATCH: O-123

Author

Avolio, A. W., Agnes, S., Lirosi, M. C., Salizzoni, M., Pinna, A. D., Gridelli, B., De Carlis, L., Colledan, M., Gerunda, G. E., Valente, U., Rossi, G., Ettorre, G. M., Risaliti, A., Mazzaferro, V., Bresadola, F., Rossi, M., Tisone, G., Zamboni, F., Lupo, L., Cuomo, O., Calise, F., Donataccio, M., Nicolotti, N., Vitale, A., Romagnoli, R, Lupo, F., Cucchetti, A., Gruttadauria, S., Mangoni, I., Pinelli, D., Montalti, R, Gelli, M., Caccamo, L., Vennarecci, G., Nicolini, D., Regalia, E., Baccarani, U., Lai, Q., Manzia, T, Tondolo, E., Rendina, M., Perrella, A., Scuderi, E., Antonelli, B., de Waure, C., De Feo, T, Burra, P., Gasbarrini, A., and Cillo, U.

Published
2011

20. Dual Kidney Transplantation: Evaluation of Recipient Selection Criteria at Niguarda Hospital

Author

Mariani, A, Ferla, F, De Carlis, R, Rossetti, O, Covucci, E, Tripepi, M, Concone, G, Lauterio, A, Mangoni, I, De Carlis, L, Mariani, A., Ferla, F., De Carlis, R., Rossetti, O., Covucci, E., Tripepi, M., Concone, G., Lauterio, A., Mangoni, I., De Carlis, L., Mariani, A, Ferla, F, De Carlis, R, Rossetti, O, Covucci, E, Tripepi, M, Concone, G, Lauterio, A, Mangoni, I, De Carlis, L, Mariani, A., Ferla, F., De Carlis, R., Rossetti, O., Covucci, E., Tripepi, M., Concone, G., Lauterio, A., Mangoni, I., and De Carlis, L.

Abstract

Background Dual kidney transplantation (DKT) is a largely accepted strategy to enlarge the donor pool. Niguarda Hospital started this program in December 2010, and 38 DKT have been performed. In our series, we included recipients older than those in the other series published in literature. The aim of this study was to know if our recipient selection criteria for DKT are safe. Methods We reviewed our data base of DKT and analyzed recipients' medical history, surgical technique, post-operative complications, graft survival, morbidity, and mortality. We then compared our results with the literature. Results From December 2010 to April 2015, 38 DKT were performed in Niguarda Hospital. Delayed graft function was present in 21 recipients. Explantation of both kidneys was performed in 1 patient and explantation of 1 kidney in 6 patients. Post-operative complications were present in 8 patients. Five patients returned to hemodialysis after DKT. One recipient died of medical post-operative sepsis. The mean follow-up was 24 months. Graft survival and patient survival were 86.84% and 97.93%, respectively. Compared with the literature, our series had similar mortality and morbidity rates, even if recipients' age was higher than in other series. Conclusions The strategy of DKT allocation in elderly recipients is safe. Further studies have to be performed to optimized selection of the recipients for DKT not to disadvantage younger patients in the transplant waiting list and to improve the technique of organ evaluation and preservation to refine graft allocation.

Published
2016

21. LIVER TRANSPLANTATION IN HIV-POSITIVE PATIENTS: THE INITIAL EXPERIENCE

Author

Di Benedetto, C, Iegri, C, Pasulo, L, Travi, G, Moioli, C, Colledan, M, De Carlis, L, Mazzarelli, C, Cologni, G, Corti, A, Mazza, E, Marchesi, M, De Gasperi, A, Mangoni, I, Mangiola, F, Belli, L, Fagiuoli, S, Puoti, M, Di Benedetto C, Iegri C, Pasulo L, Travi G, Moioli C, Colledan M, De Carlis L, Mazzarelli C, Cologni G, Corti A, Mazza E, Marchesi M, De Gasperi A, Mangoni I, Mangiola F, Belli L, Fagiuoli S, Puoti M, Di Benedetto, C, Iegri, C, Pasulo, L, Travi, G, Moioli, C, Colledan, M, De Carlis, L, Mazzarelli, C, Cologni, G, Corti, A, Mazza, E, Marchesi, M, De Gasperi, A, Mangoni, I, Mangiola, F, Belli, L, Fagiuoli, S, Puoti, M, Di Benedetto C, Iegri C, Pasulo L, Travi G, Moioli C, Colledan M, De Carlis L, Mazzarelli C, Cologni G, Corti A, Mazza E, Marchesi M, De Gasperi A, Mangoni I, Mangiola F, Belli L, Fagiuoli S, and Puoti M

Published
2016

22. Prevalent use of Combined Prophylaxis of Hepatitis B after liver transplantation in Italy: Results of a national survey in a large cohort

Author

Marzano, A, Andreone, P, Boccagni, P, Burra, P, Caneschi, F, Conoscitore, P, Coppola, C, De Carlis, L, Fagiuoli, S, Forte, P, Gaeta, G, Iemmolo, R, Suffredini, A, Mazzola, M, Merli, M, Parrilli, G, Piai, G, Piras, M, Salizzoni, M, Tamè, M, Tisone, G, Toniutto, P, Vennarecci, G, Volpes, R, Zamboni, F, Caccamo, L, Bertuzzo, V, Bongiovanni, A, Brin-Dicci, G, Cocchis, D, Ettorre, G, Gianni, E, Giusto, M, Lenisa, I, Lucà, M, Mameli, L, Mangoni, I, Manini, M, Paoli, S, Russo, F, Staiano, L, Stornaiuolo, G, Toti, L, Valente, G, Vukotic, R, Marzano, Alfredo, Andreone, Pietro, Boccagni, Patrizia, Burra, Patrizia, Caneschi, Francesco, Conoscitore, Pasquale F., Coppola, Carmine, De Carlis, Luciano, Fagiuoli, Stefano, Forte, Paolo, Gaeta, Giovanni B., Iemmolo, Rosa M., Suffredini, Anna Lotti, Mazzola, Michele, Merli, Manuela, Parrilli, Gianpaolo, Piai, Guido, Piras, Maria R., Salizzoni, Mauro, Tamè, Mariarosa, Tisone, Giuseppe, Toniutto, Pierluigi, Vennarecci, Giovanni, Volpes, Riccardo, Zamboni, Fausto, Caccamo, Lucio, Bertuzzo, Valentina R., Bongiovanni, Assunta S., Brin-Dicci, Gaetano, Cocchis, Donatella, Ettorre, Giuseppe M., Gianni, Elena, Giusto, Michela, Lenisa, Ilaria, Lucà, Maria G., Mameli, Laura, Mangoni, Iacopo, Manini, Matteo A., Paoli, Serena, Russo, Francesco P., Staiano, Laura, Stornaiuolo, Gianfranca, Toti, Luca, Valente, Giovanna, Vukotic, Ranka, Marzano, A, Andreone, P, Boccagni, P, Burra, P, Caneschi, F, Conoscitore, P, Coppola, C, De Carlis, L, Fagiuoli, S, Forte, P, Gaeta, G, Iemmolo, R, Suffredini, A, Mazzola, M, Merli, M, Parrilli, G, Piai, G, Piras, M, Salizzoni, M, Tamè, M, Tisone, G, Toniutto, P, Vennarecci, G, Volpes, R, Zamboni, F, Caccamo, L, Bertuzzo, V, Bongiovanni, A, Brin-Dicci, G, Cocchis, D, Ettorre, G, Gianni, E, Giusto, M, Lenisa, I, Lucà, M, Mameli, L, Mangoni, I, Manini, M, Paoli, S, Russo, F, Staiano, L, Stornaiuolo, G, Toti, L, Valente, G, Vukotic, R, Marzano, Alfredo, Andreone, Pietro, Boccagni, Patrizia, Burra, Patrizia, Caneschi, Francesco, Conoscitore, Pasquale F., Coppola, Carmine, De Carlis, Luciano, Fagiuoli, Stefano, Forte, Paolo, Gaeta, Giovanni B., Iemmolo, Rosa M., Suffredini, Anna Lotti, Mazzola, Michele, Merli, Manuela, Parrilli, Gianpaolo, Piai, Guido, Piras, Maria R., Salizzoni, Mauro, Tamè, Mariarosa, Tisone, Giuseppe, Toniutto, Pierluigi, Vennarecci, Giovanni, Volpes, Riccardo, Zamboni, Fausto, Caccamo, Lucio, Bertuzzo, Valentina R., Bongiovanni, Assunta S., Brin-Dicci, Gaetano, Cocchis, Donatella, Ettorre, Giuseppe M., Gianni, Elena, Giusto, Michela, Lenisa, Ilaria, Lucà, Maria G., Mameli, Laura, Mangoni, Iacopo, Manini, Matteo A., Paoli, Serena, Russo, Francesco P., Staiano, Laura, Stornaiuolo, Gianfranca, Toti, Luca, Valente, Giovanna, and Vukotic, Ranka

Abstract

BACKGROUND: Prophylaxis of hepatitis B after liver transplantation with antiviral(s) and immunoglobulins effciently protect the majority of recipients; however recent experiences suggest a decline of HBsag-positive candidates and the use of hepatitis B immunoglobulin-free schedules. MetHoDs: this national survey evaluated the epidemiology and clinical results of hepatitis B prophylaxis among 10,365 liver transplants performed in 25 years in 13 italian centers. RESULTS: With a percentage of 22, 2260 procedures were performed in HBsAg-positive recipients and 714 out of 1080 anti-HBc-positive grafts were used in HBsag-negative recipients; a total of 2974 patients (29%) were considered at risk of hepatitis B after liver transplantation. similar rates (18% of HBsag-positive candidates and 15% of anti-HBc-positive grafts) were registered in the last collected year. combined prophylaxis with Hepatitis B immunoglobulins remained prevalent among centers and was effective in 96% of HBsag-positive recipients and in 94% of HBsag-negative recipients of anti-HBc-positive grafts. CONCLUSIONS: Data from this survey confrm: the excellent results of combined prophylaxis; the past and persistent use of Hepatitis B immunoglobulin-on and only rare-off prophylactic regimens, in contrast with the newest reports; the increasing use of anti-HBc-positive grafts; the past and present high prevalence of HBsag-positive recipients, due to an increase in candidates with either hepatocellular carcinoma and Hepatitis Delta Virus coinfection in the last years

Published
2018

23. Split-liver full-left full-right: Proposal for an operative protocol (Transplantation Proceedings (2014) 46:7 (2279-2282)) Erratum

Author

Ferla, F, Lauterio, A, Di Sandro, S, Mangoni, I, Poli, C, Concone, G, Cusumano, C, Giacomoni, A, Andorno, E, De Carlis, L, Ferla, F., Lauterio, A., Di Sandro, S., Mangoni, I., Poli, C., Concone, G., Cusumano, C., Giacomoni, A., Andorno, E., De Carlis, L., Ferla, F, Lauterio, A, Di Sandro, S, Mangoni, I, Poli, C, Concone, G, Cusumano, C, Giacomoni, A, Andorno, E, De Carlis, L, Ferla, F., Lauterio, A., Di Sandro, S., Mangoni, I., Poli, C., Concone, G., Cusumano, C., Giacomoni, A., Andorno, E., and De Carlis, L.

Published
2014

24. Split-liver full-left full-right: Proposal for an operative protocol (Transplantation Proceedings (2014) 46:7 (2279-2282)) Erratum

Author

Ferla, F., Ferla, F, Lauterio, A, Di Sandro, S, Mangoni, I, Poli, C, Concone, G, Cusumano, C, Giacomoni, A, Andorno, E, De Carlis, L, Ferla, F., Lauterio, A., Di Sandro, S., Mangoni, I., Poli, C., Concone, G., Cusumano, C., Giacomoni, A., Andorno, E., De Carlis, L., Ferla, F., Ferla, F, Lauterio, A, Di Sandro, S, Mangoni, I, Poli, C, Concone, G, Cusumano, C, Giacomoni, A, Andorno, E, De Carlis, L, Ferla, F., Lauterio, A., Di Sandro, S., Mangoni, I., Poli, C., Concone, G., Cusumano, C., Giacomoni, A., Andorno, E., and De Carlis, L.

Published
2014

25. Balancing donor and recipient risk factors in liver transplantation: the value of D-MELD with particular reference to HCV recipients

Author

Avolio, A, Cillo, U, Salizzoni, M, DE CARLIS, LUCIANO GREGORIO, Colledan, M, Gerunda, G, Mazzaferro, V, Tisone, G, Romagnoli, R, Caccamo, L, Rossi, M, Vitale, A, Cucchetti, A, Lupo, L, Gruttadauria, S, Nicolotti, N, Burra, P, Gasbarrini, A, Agnes, S, Lirosi, M, Miele, L, Pompili, M, Siciliano, M, Perilli, V, Gaspari, R, Castagneto, M, Lupo, F, Tandoi, F, De Carlis, L, Mangoni, I, Belli, L, Pinna, A, Cescon, M, Gridelli, B, Li Petri, S, Volpes, R, Pinelli, D, Fagiuoli, S, Montalti, R, Regalia, E, Rossi, G, Antonelli, B, Berloco, P, Lai, Q, Risaliti, A, Nicolini, D, Valente, U, Gelli, M, Morelli, N, Zamboni, F, Tondolo, V, Ettorre, G, Vennarecci, G, Bresadola, F, Baccarani, U, Toniutto, P, Manzia, T, Anselmo, A, Angelico, M, Calise, F, Scuderi, V, Romano, M, Rendina, M, Barone, M, Cuomo, O, Perrella, A, Santaniello, W, Donataccio, M, Dalle Ore, G, De Ville De Goyet, J, Monti, L, De Waure, C., Avolio A.W., Cillo U., Salizzoni M., De Carlis L., Colledan M., Gerunda G.E., Mazzaferro V., Tisone G., Romagnoli R., Caccamo L., Rossi M., Vitale A., Cucchetti A., Lupo L., Gruttadauria S., Nicolotti N., Burra P., Gasbarrini A., Agnes S., Lirosi M.C., Miele L., Pompili M., Siciliano M., Perilli V., Gaspari R., Castagneto M., Tandoi F., Mangoni I., Belli L., Pinna A.D., Cescon M., Gridelli B., Li Petri S., Volpes R., Pinelli D., Fagiuoli S., Montalti R., Regalia E., Rossi G., Antonelli B., Berloco P., Lai Q., Risaliti A., Nicolini D., Valente U., Gelli M., Morelli N., Zamboni F., Tondolo V., Brotzu G., Ettorre G.M., Vennarecci G., Bresadola F., Baccarani U., Toniutto P.L., Manzia T., Anselmo A., Angelico M., Calise F., Scuderi V., Romano M., Rendina M., Barone M., Cuomo O., Perrella A., Santaniello W., Donataccio M., Dalle Ore G., de Ville de J., Monti L., Avolio, A W, Cillo, U, Salizzoni, M, De Carlis, L, Colledan, M, Gerunda, G E, Mazzaferro, Mariapia, Tisone, G, Romagnoli, R, Caccamo, L, Rossi, M, Vitale, A, Cucchetti, A, Lupo, L, Gruttadauria, S, Nicolotti, N, Burra, P, Gasbarrini, A, Agnes, S, Montalti, Roberto, Avolio, A, DE CARLIS, L, Gerunda, G, Mazzaferro, V, Lirosi, M, Miele, L, Pompili, M, Siciliano, M, Perilli, V, Gaspari, R, Castagneto, M, Lupo, F, Tandoi, F, Mangoni, I, Belli, L, Pinna, A, Cescon, M, Gridelli, B, Li Petri, S, Volpes, R, Pinelli, D, Fagiuoli, S, Montalti, R, Regalia, E, Rossi, G, Antonelli, B, Berloco, P, Lai, Q, Risaliti, A, Nicolini, D, Valente, U, Gelli, M, Morelli, N, Zamboni, F, Tondolo, V, Ettorre, G, Vennarecci, G, Bresadola, F, Baccarani, U, Toniutto, P, Manzia, T, Anselmo, A, Angelico, M, Calise, F, Scuderi, V, Romano, M, Rendina, M, Barone, M, Cuomo, O, Perrella, A, Santaniello, W, Donataccio, M, Dalle Ore, G, De Ville De Goyet, J, Monti, L, and De Waure, C

Subjects
Graft Rejection, Male, medicine.medical_treatment, Settore MED/18 - CHIRURGIA GENERALE, Hepacivirus, Liver transplantation, Gastroenterology, Liver disease, Postoperative Complications, Retrospective Studie, UNSUSTAINABLE MATCH, Models, Risk Factors, Immunology and Allergy, Health Status Indicators, Age Factor, PROGNOSTIC INDICES, Pharmacology (medical), Health Status Indicator, D-MELD, Liver Transplantation, liver transplantation, Hazard ratio, Graft Survival, donor-recipient match, outcome, prognosis, risk factors, Age Factors, Trapianto epatico, Hepatitis C, Hepatitis B, Statistical, Middle Aged, Prognosis, Tissue Donors, Survival Rate, Italy, HCV, Female, Human, Adult, medicine.medical_specialty, Prognosi, Donor Selection, End Stage Liver Disease, Young Adult, Internal medicine, medicine, Humans, fattori di rischio, Aged, Retrospective Studies, Transplantation, Hepaciviru, Models, Statistical, business.industry, Donor selection, Risk Factor, Settore MED/09 - MEDICINA INTERNA, Odds ratio, medicine.disease, Settore MED/18, Surgery, body regions, Postoperative Complication, business
Abstract

Donor-recipient match is a matter of debate in liver transplantation. D-MELD (donor age × recipient biochemical model for end-stage liver disease [MELD]) and other factors were analyzed on a national Italian database recording 5946 liver transplants. Primary endpoint was to determine factors predictive of 3-year patient survival. D-MELD cutoff predictive of 5-year patient survival 1628). At 3 years, the odds ratio (OR) for death was 2.03 (95% confidence interval [CI], 1.44-2.85) in D-MELD class C versus B. The OR was 0.40 (95% CI, 0.24-0.66) in class A versus class B. Other predictors were hepatitis C virus (HCV; OR = 1.42; 95% CI, 1.11-1.81), hepatitis B virus (HBV; OR = 0.69; 95% CI, 0.51-0.93), retransplant (OR = 1.82; 95% CI, 1.16-2.87) and low-volume center (OR = 1.48; 95% CI, 1.11-1.99). Cox regressions up to 90 months confirmed results. The hazard ratio was 1.97 (95% CI, 1.59-2.43) for D-MELD class C versus class B and 0.42 (95% CI, 0.29-0.60) for D-MELD class A versus class B. Recipient age, HCV, HBV and retransplant were also significant. The 5yrsPS

Published
2011

26. Successful pre- and posttransplant sofosbuvir-based anti-hepatitis C virus treatment in persons living with human immunodeficiency virus infection

Author

Guaraldi, G, Rossotti, R, Verucchi, G, Tavio, M, Pasulo, L, Beghetto, B, Dolci, G, Nardini, G, Badia, L, Magliano, A, Moioli, M, Puoti, M, Travi, G, Pazzi, A, De Carlis, L, Giacomoni, A, Lauterio, A, Mangoni, I, Di Sandro, S, Ferla, F, Fagiuoli, S, Colledan, M, Cologni, G, Di Benedetto, F, Tarantino, G, Serra, V, Moioli, MC, Guaraldi, G, Rossotti, R, Verucchi, G, Tavio, M, Pasulo, L, Beghetto, B, Dolci, G, Nardini, G, Badia, L, Magliano, A, Moioli, M, Puoti, M, Travi, G, Pazzi, A, De Carlis, L, Giacomoni, A, Lauterio, A, Mangoni, I, Di Sandro, S, Ferla, F, Fagiuoli, S, Colledan, M, Cologni, G, Di Benedetto, F, Tarantino, G, Serra, V, and Moioli, MC

Abstract

This retrospective study reports the data of sofosbuvir-based anti-hepatitis C virus treatment in 24 candidates and 24 recipients of liver transplantation coinfected with human immunodeficiency virus. Sustained virologic response was cumulatively 85% (90% and 100% in those treated with optimal schedules pre- and posttransplant, respectively).

Published
2017

27. The European Policy for Liver Allocation in Patients Affected by Hepatocellular Carcinoma

Author

Di Sandro, S, Ferla, F, Lauterio, A, Mangoni, I, De Carlis, R, Buscemi, V, De Carlis, L, Di Sandro, S, Ferla, F, Lauterio, A, Mangoni, I, De Carlis, R, Buscemi, V, and De Carlis, L

Abstract

The main goal of allocation system is to guarantee an equal access to the limited resource of liver grafts for every class of patients on the waiting list, balancing between the ethical principles of equity, utility, benefit, need, and fairness. The aim of this review was to analyze liver allocation policies among these organizations, focusing on HCC. The European area considered for this analysis included 6 macro-areas or countries, which are congregated from the same policy of liver sharing and allocation. By this definition, the 6 areas identified are: Centro Nazionale Trapianti (CNT) in Italy; Eurotransplant (Germany, the Netherlands, Belgium, Luxembourg, Austria, Hungary, Slovenia, and Croatia); Organizacion Nacional de Transplantes (ONT) in Spain; Etablissement francais des Greffes (EfG) in France; NHS Blood Transplant (NHSBT) in the United Kingdom and Ireland; Scandiatransplant (Sweden, Norway, Finland, Denmark, and Iceland); Romanian National Policy. Each identified area, as network for organ sharing in Europe, adopts a basic allocation system that consider a policy center oriented or patient oriented. Priorization of patients affected by HCC in the waiting list for deceased donors liver transplant worldwide is dominated by 2 main principles: urgency and utility. The main message of this review is the absence of a common organs allocation policy over the Eurpean countries. Despite that, long-term survival of the community of patients listed for transplant due to HCC results, however, highly acceptable in Europe and comparable to the long-term survial reported in the UNOS register

Published
2017

28. Evolution of robotic nephrectomy for living donation: From hand-assisted to totally robotic technique

Author

Giacomoni, A, Di Sandro, S, Lauterio, A, Concone, G, Mangoni, I, Mihaylov, P, Tripepi, M, De Carlis, L., Giacomoni, A, Di Sandro, S, Lauterio, A, Concone, G, Mangoni, I, Mihaylov, P, Tripepi, M, and DE CARLIS, L

Subjects
Adult, Male, Living Donor, Robotic Surgical Procedure, Intraoperative Complication, Operative Time, Nephrectomy, Robotic-assisted nephrectomy, Kidney transplantation, Robotic Surgical Procedures, Ischemia, Living Donors, Living donation, Humans, Postoperative Period, Intraoperative Complications, Aged, Medicine (all), Computer Science Applications1707 Computer Vision and Pattern Recognition, Middle Aged, Kidney Transplantation, Biophysic, Tissue and Organ Harvesting, Female, Laparoscopy, Surgery, Human
Abstract

Background: The application of robotic-assisted surgery offers EndoWrist instruments and 3-D visualization of the operative field, which are improvements over traditional laparoscopy. The results of the few studies published so far have shown that living donor nephrectomy using the robot-assisted technique is safe, feasible, and offers advantages to patients. Materials and methods: Since November 2009, 16 patients have undergone robotic-assisted living donor nephrectomy at our Institute. Patients were divided into two groups according to the surgical technique adopted for the procedure: Group A, hand-assisted robotic nephrectomy (eight patients); Group B, totally robotic nephrectomy (eight patients). Results: Intra-operative bleeding was similar in the two groups (90 vs 100mL for Group A and B, respectively). Median warm ischemia time was significantly shorter in Group A (2.3 vs 5.1min for Group A and B, respectively, P-value=0.05). Switching to the open procedure was never required. Median operative time was not significantly longer in Group A than Group B (275min vs 250min, respectively). Conclusion: Robotic assisted living kidney recovery is a safe and effective procedure. Considering the overall technical, clinical, and feasibility aspects of living kidney donation, we believe that the robotic assisted technique is the method of choice for surgeon's comfort and donors' safety

Published
2014

29. D-MELD, a Powerful Instrument To Optimize Donor-2-Recipient Match. Differences between US and Italy

Author

Avolio, A, Halldorson, J, Lirosi, M, Agnes, S, Salizzoni, M, Pinna, A, Spada, M, De Carlis, L, Colledan, M, Gerunda, G, Andorno, E, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Rossi, M, Tisone, G, Zamboni, F, Vivarelli, M, Lupo, L, Cuomo, O, Calise, F, Nicolotti, N, Vitale, A, Romagnoli, R, Cucchetti, A, Bonsignore, P, Mangoni, I, Pinelli, D, Montalti, R, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Santaniello, W, Bottino, G, Spagnoletti, G, Mariano, G, Gasbarrini, A, Burra, P, Cillo, U, Avolio A, Halldorson J, Lirosi M, Agnes S, Salizzoni M, Pinna A, Spada M, De Carlis L, Colledan M, Gerunda G, Andorno E, Rossi G, Ettorre G, Risaliti A, Mazzaferro V, Rossi M, Tisone G, Zamboni F, Vivarelli M, Lupo L, Cuomo O, Calise F, Nicolotti N, Vitale A, Romagnoli R, Cucchetti A, Bonsignore P, Mangoni I, Pinelli D, Montalti R, Caccamo L, Vennarecci G, Nicolini D, Regalia E, Baccarani U, Lai Q, Manzia T, Tondolo E, Rendina M, Perrella A, Santaniello W, Bottino G, Spagnoletti G, Mariano G, Gasbarrini A, Burra P, Cillo U, Avolio, A, Halldorson, J, Lirosi, M, Agnes, S, Salizzoni, M, Pinna, A, Spada, M, De Carlis, L, Colledan, M, Gerunda, G, Andorno, E, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Rossi, M, Tisone, G, Zamboni, F, Vivarelli, M, Lupo, L, Cuomo, O, Calise, F, Nicolotti, N, Vitale, A, Romagnoli, R, Cucchetti, A, Bonsignore, P, Mangoni, I, Pinelli, D, Montalti, R, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Santaniello, W, Bottino, G, Spagnoletti, G, Mariano, G, Gasbarrini, A, Burra, P, Cillo, U, Avolio A, Halldorson J, Lirosi M, Agnes S, Salizzoni M, Pinna A, Spada M, De Carlis L, Colledan M, Gerunda G, Andorno E, Rossi G, Ettorre G, Risaliti A, Mazzaferro V, Rossi M, Tisone G, Zamboni F, Vivarelli M, Lupo L, Cuomo O, Calise F, Nicolotti N, Vitale A, Romagnoli R, Cucchetti A, Bonsignore P, Mangoni I, Pinelli D, Montalti R, Caccamo L, Vennarecci G, Nicolini D, Regalia E, Baccarani U, Lai Q, Manzia T, Tondolo E, Rendina M, Perrella A, Santaniello W, Bottino G, Spagnoletti G, Mariano G, Gasbarrini A, Burra P, and Cillo U

Published
2013

30. THE UN-SUSTAINABLE MATCH IN HCV LIVER TRANSPLANT PATIENTS

Author

Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Bresadola, F, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Vitale, A, Nicolotti, N, Romagnoli, R, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Scuderi, E, Antonelli, B, de Waure, C, Angelico, M, Burra, P, Gasbarrini, A, Cillo, U, Avolio AW, Agnes S, Lirosi MC, Salizzoni M, Pinna A, Gridelli B, De Carlis L, Colledan M, Gerunda G, Valente U, Rossi G, Ettorre G, Risaliti A, Mazzaferro V, Bresadola F, Rossi M, Tisone G, Zamboni F, Lupo L, Cuomo O, Calise F, Vitale A, Nicolotti N, Romagnoli R, Cucchetti A, Gruttadauria S, Mangoni I, Pinelli D, Montalti R, Gelli M, Caccamo L, Vennarecci G, Nicolini D, Regalia E, Baccarani U, Lai Q, Manzia T, Tondolo E, Rendina M, Perrella A, Scuderi E, Antonelli B, de Waure C, Angelico M, Burra P, Gasbarrini A, Cillo U, Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Bresadola, F, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Vitale, A, Nicolotti, N, Romagnoli, R, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Scuderi, E, Antonelli, B, de Waure, C, Angelico, M, Burra, P, Gasbarrini, A, Cillo, U, Avolio AW, Agnes S, Lirosi MC, Salizzoni M, Pinna A, Gridelli B, De Carlis L, Colledan M, Gerunda G, Valente U, Rossi G, Ettorre G, Risaliti A, Mazzaferro V, Bresadola F, Rossi M, Tisone G, Zamboni F, Lupo L, Cuomo O, Calise F, Vitale A, Nicolotti N, Romagnoli R, Cucchetti A, Gruttadauria S, Mangoni I, Pinelli D, Montalti R, Gelli M, Caccamo L, Vennarecci G, Nicolini D, Regalia E, Baccarani U, Lai Q, Manzia T, Tondolo E, Rendina M, Perrella A, Scuderi E, Antonelli B, de Waure C, Angelico M, Burra P, Gasbarrini A, and Cillo U

Published
2012

31. The UN-SUSTAINABLE Match in HCV Recipients. Evidences from the Italian D-MELD Study on Balancing Donor-Recipient Risk Factors

Author

Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Donataccio, M, Nicolotti, N, Romagnoli, R, Vitale, A, Cucchetti, A, Gruttadauria, S, Baccarani, U, Caccamo, L, Mangoni, I, Pinelli, D, Montalti, R, Morelli, N, Vennarecci, G, Nicolini, D, Regalia, E, Lai, Q, Anselmo, A, Tondolo, E, Perrella, A, Burra, P, Cillo, U, Avolio AW, Agnes S, Lirosi M, Salizzoni M, Pinna A, Gridelli B, De Carlis L, Colledan M, Gerunda G, Rossi G, Ettorre G, Risaliti A, Mazzaferro V, Rossi M, Tisone G, Zamboni F, Lupo L, Cuomo O, Calise F, Donataccio M, Nicolotti N, Romagnoli R, Vitale A, Cucchetti A, Gruttadauria S, Baccarani U, Caccamo L, Mangoni I, Pinelli D, Montalti R, Morelli N, Vennarecci G, Nicolini D, Regalia E, Lai Q, Anselmo A, Tondolo E, Perrella A, Burra P, Cillo U, Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Donataccio, M, Nicolotti, N, Romagnoli, R, Vitale, A, Cucchetti, A, Gruttadauria, S, Baccarani, U, Caccamo, L, Mangoni, I, Pinelli, D, Montalti, R, Morelli, N, Vennarecci, G, Nicolini, D, Regalia, E, Lai, Q, Anselmo, A, Tondolo, E, Perrella, A, Burra, P, Cillo, U, Avolio AW, Agnes S, Lirosi M, Salizzoni M, Pinna A, Gridelli B, De Carlis L, Colledan M, Gerunda G, Rossi G, Ettorre G, Risaliti A, Mazzaferro V, Rossi M, Tisone G, Zamboni F, Lupo L, Cuomo O, Calise F, Donataccio M, Nicolotti N, Romagnoli R, Vitale A, Cucchetti A, Gruttadauria S, Baccarani U, Caccamo L, Mangoni I, Pinelli D, Montalti R, Morelli N, Vennarecci G, Nicolini D, Regalia E, Lai Q, Anselmo A, Tondolo E, Perrella A, Burra P, and Cillo U

Published
2012

32. Behind D-MELD: The Role of Primary Indication (HCV or HBV) as Significant Covariate in the Outcome Prediction after Liver Transplants

Author

Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Nicolotti, N, Vitale, A, Romagnoli, R, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Scuderi, E, Burra, P, Gasbarrini, A, Cillo, U, Avolio AW, Agnes S, Lirosi MC, Salizzoni M, Pinna A, Gridelli B, De Carlis L, Colledan M, Gerunda G, Valente U, Rossi G, Ettorre G, Risaliti A, Mazzaferro V, Rossi M, Tisone G, Zamboni F, Lupo L, Cuomo O, Calise F, Nicolotti N, Vitale A, Romagnoli R, Cucchetti A, Gruttadauria S, Mangoni I, Pinelli D, Montalti R, Gelli M, Caccamo L, Vennarecci G, Nicolini D, Regalia E, Baccarani U, Lai Q, Manzia T, Tondolo E, Rendina M, Perrella A, Scuderi E, Burra P, Gasbarrini A, Cillo U, Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Nicolotti, N, Vitale, A, Romagnoli, R, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Scuderi, E, Burra, P, Gasbarrini, A, Cillo, U, Avolio AW, Agnes S, Lirosi MC, Salizzoni M, Pinna A, Gridelli B, De Carlis L, Colledan M, Gerunda G, Valente U, Rossi G, Ettorre G, Risaliti A, Mazzaferro V, Rossi M, Tisone G, Zamboni F, Lupo L, Cuomo O, Calise F, Nicolotti N, Vitale A, Romagnoli R, Cucchetti A, Gruttadauria S, Mangoni I, Pinelli D, Montalti R, Gelli M, Caccamo L, Vennarecci G, Nicolini D, Regalia E, Baccarani U, Lai Q, Manzia T, Tondolo E, Rendina M, Perrella A, Scuderi E, Burra P, Gasbarrini A, and Cillo U

Published
2012

33. D-MELD, a Powerful Instrument To Optimize Donor-2-Recipient Match. Differences between US and Italy

Author

Avolio A, Halldorson J, Lirosi M, Agnes S, Salizzoni M, Pinna A, Spada M, De Carlis L, Colledan M, Gerunda G, Andorno E, Rossi G, Ettorre G, Risaliti A, Mazzaferro V, Rossi M, Tisone G, Zamboni F, Vivarelli M, Lupo L, Cuomo O, Calise F, Nicolotti N, Vitale A, Romagnoli R, Cucchetti A, Bonsignore P, Mangoni I, Pinelli D, Montalti R, Caccamo L, Vennarecci G, Nicolini D, Regalia E, Baccarani U, Lai Q, Manzia T, Tondolo E, Rendina M, Perrella A, Santaniello W, Bottino G, Spagnoletti G, Mariano G, Gasbarrini A, Burra P, Cillo U, Avolio, A, Halldorson, J, Lirosi, M, Agnes, S, Salizzoni, M, Pinna, A, Spada, M, De Carlis, L, Colledan, M, Gerunda, G, Andorno, E, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Rossi, M, Tisone, G, Zamboni, F, Vivarelli, M, Lupo, L, Cuomo, O, Calise, F, Nicolotti, N, Vitale, A, Romagnoli, R, Cucchetti, A, Bonsignore, P, Mangoni, I, Pinelli, D, Montalti, R, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Santaniello, W, Bottino, G, Spagnoletti, G, Mariano, G, Gasbarrini, A, Burra, P, and Cillo, U

Subjects
Transplantation, Surgery
Published
2013

34. Use of HBcAb Positive Liver Grafts. Medium Term Results According to Donor-Recipient Risk Factors

Author

Avolio, A, Agnes, S, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Bresadola, F, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Lirosi, M, Vitale, A, Nicolotti, N, Romagnoli, R, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Scudieri, E, Antonelli, B, de Waure, C, De Feo, T, Burra, P, Gasbarrini, A, Cillo, U, Avolio A, Agnes S, Salizzoni M, Pinna A, Gridelli B, De Carlis L, Colledan M, Gerunda G, Valente U, Rossi G, Ettorre G, Risaliti A, Mazzaferro V, Bresadola F, Rossi M, Tisone G, Zamboni F, Lupo L, Cuomo O, Calise F, Lirosi M, Vitale A, Nicolotti N, Romagnoli R, Cucchetti A, Gruttadauria S, Mangoni I, Pinelli D, Montalti R, Gelli M, Caccamo L, Vennarecci G, Nicolini D, Regalia E, Baccarani U, Lai Q, Manzia T, Tondolo E, Rendina M, Perrella A, Scudieri E, Antonelli B, de Waure C, De Feo T, Burra P, Gasbarrini A, Cillo U, Avolio, A, Agnes, S, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Bresadola, F, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Lirosi, M, Vitale, A, Nicolotti, N, Romagnoli, R, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Scudieri, E, Antonelli, B, de Waure, C, De Feo, T, Burra, P, Gasbarrini, A, Cillo, U, Avolio A, Agnes S, Salizzoni M, Pinna A, Gridelli B, De Carlis L, Colledan M, Gerunda G, Valente U, Rossi G, Ettorre G, Risaliti A, Mazzaferro V, Bresadola F, Rossi M, Tisone G, Zamboni F, Lupo L, Cuomo O, Calise F, Lirosi M, Vitale A, Nicolotti N, Romagnoli R, Cucchetti A, Gruttadauria S, Mangoni I, Pinelli D, Montalti R, Gelli M, Caccamo L, Vennarecci G, Nicolini D, Regalia E, Baccarani U, Lai Q, Manzia T, Tondolo E, Rendina M, Perrella A, Scudieri E, Antonelli B, de Waure C, De Feo T, Burra P, Gasbarrini A, and Cillo U

Published
2011

35. www.D-MELD.com. The online prognostic calculator to optimize donor-recipient match

Author

Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Bresadola, F, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Donataccio, M, Nicolotti, N, Vitale, A, Romagnoli, R, Lupo, F, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Scuderi, E, Antonelli, B, de Waure, C, De Feo, T, Burra, P, Gasbarrini, A, Cillo, U, Avolio AW, Agnes S, Lirosi MC, Salizzoni M, Pinna AD, Gridelli B, De Carlis L, Colledan M, Gerunda GE, Valente U, Rossi G, Ettorre GM, Risaliti A, Mazzaferro V, Bresadola F, Rossi M, Tisone G, Zamboni F, Lupo L, Cuomo O, Calise F, Donataccio M, Nicolotti N, Vitale A, Romagnoli R, Lupo F, Cucchetti A, Gruttadauria S, Mangoni I, Pinelli D, Montalti R, Gelli M, Caccamo L, Vennarecci G, Nicolini D, Regalia E, Baccarani U, Lai Q, Manzia T, Tondolo E, Rendina M, Perrella A, Scuderi E, Antonelli B, de Waure C, De Feo T, Burra P, Gasbarrini A, Cillo U, Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Bresadola, F, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Donataccio, M, Nicolotti, N, Vitale, A, Romagnoli, R, Lupo, F, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Scuderi, E, Antonelli, B, de Waure, C, De Feo, T, Burra, P, Gasbarrini, A, Cillo, U, Avolio AW, Agnes S, Lirosi MC, Salizzoni M, Pinna AD, Gridelli B, De Carlis L, Colledan M, Gerunda GE, Valente U, Rossi G, Ettorre GM, Risaliti A, Mazzaferro V, Bresadola F, Rossi M, Tisone G, Zamboni F, Lupo L, Cuomo O, Calise F, Donataccio M, Nicolotti N, Vitale A, Romagnoli R, Lupo F, Cucchetti A, Gruttadauria S, Mangoni I, Pinelli D, Montalti R, Gelli M, Caccamo L, Vennarecci G, Nicolini D, Regalia E, Baccarani U, Lai Q, Manzia T, Tondolo E, Rendina M, Perrella A, Scuderi E, Antonelli B, de Waure C, De Feo T, Burra P, Gasbarrini A, and Cillo U

Published
2011

36. OPTIMIZATION OF DONOR-RECIPIENT MATCH AND IDENTIFICATION OF THE FUTILE MATCH CUTOFF. A NATIONAL ITALIAN STUDY ON LIVER TRANSPLANTATION

Author

Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Bresadola, F, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Donataccio, M, Nicolotti, N, Vitale, A, Romagnoli, R, Lupo, F, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Barone, M, Perrella, A, Romano, M, de Waure, C, Burra, P, Gasbarrini, A, Cillo, U, Avolio AW, Agnes S, Lirosi MC, Salizzoni M, Pinna AD, Gridelli B, De Carlis L, Colledan M, Gerunda GE, Valente U, Rossi G, Ettorre GM, Risaliti A, Mazzaferro V, Bresadola F, Rossi M, Tisone G, Zamboni F, Lupo L, Cuomo O, Calise F, Donataccio M, Nicolotti N, Vitale A, Romagnoli R, Lupo F, Cucchetti A, Gruttadauria S, Mangoni I, Pinelli D, Montalti R, Gelli M, Caccamo L, Vennarecci G, Nicolini D, Regalia E, Baccarani U, Lai Q, Manzia T, Tondolo E, Rendina M, Barone M, Perrella A, Romano M, de Waure C, Burra P, Gasbarrini A, Cillo U, Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Bresadola, F, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Donataccio, M, Nicolotti, N, Vitale, A, Romagnoli, R, Lupo, F, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Barone, M, Perrella, A, Romano, M, de Waure, C, Burra, P, Gasbarrini, A, Cillo, U, Avolio AW, Agnes S, Lirosi MC, Salizzoni M, Pinna AD, Gridelli B, De Carlis L, Colledan M, Gerunda GE, Valente U, Rossi G, Ettorre GM, Risaliti A, Mazzaferro V, Bresadola F, Rossi M, Tisone G, Zamboni F, Lupo L, Cuomo O, Calise F, Donataccio M, Nicolotti N, Vitale A, Romagnoli R, Lupo F, Cucchetti A, Gruttadauria S, Mangoni I, Pinelli D, Montalti R, Gelli M, Caccamo L, Vennarecci G, Nicolini D, Regalia E, Baccarani U, Lai Q, Manzia T, Tondolo E, Rendina M, Barone M, Perrella A, Romano M, de Waure C, Burra P, Gasbarrini A, and Cillo U

Published
2011

38. Hepatocellular Carcinoma in Unrelated Viral Cirrhosis: Long-Term Results After Liver Transplantation

Author

Lauterio, A, Di Sandro, S, Slim, A, Giacomoni, A, Mangoni, I, Mihaylov, P, Pirotta, V, Aseni, P, De Carlis, L, Lauterio, A., Di Sandro, S., Slim, A., Giacomoni, A., Mangoni, I., Mihaylov, P., Pirotta, V., Aseni, P., De Carlis, L., Lauterio, A, Di Sandro, S, Slim, A, Giacomoni, A, Mangoni, I, Mihaylov, P, Pirotta, V, Aseni, P, De Carlis, L, Lauterio, A., Di Sandro, S., Slim, A., Giacomoni, A., Mangoni, I., Mihaylov, P., Pirotta, V., Aseni, P., and De Carlis, L.

Abstract

Introduction: Chronic viral hepatitis is considered to be the most significant risk factor for development of hepatocellular carcinoma (HCC). Nevertheless, about 5%-15% of HCC occur in noncirrhotic or virus-unrelated cirrhotic patients. The natural history of HCC in terms of incidence, clinical features, and tumor progression differs according to the underlying cancerogenic factors and differences in hepatocarcinogenetic pathways. Little is know about the relationship between HCC outcomes after liver transplantation (OLT) and the primary liver disease. We retrospectively analyzed the outcomes of patients transplanted due to HCC in settings of either virus-related or virus-unrelated cirrhosis. Patients and Methods: From January 2000 to December 2007, 179 patients underwent OLT due to HCC: 157 (87.8%) affected by virus-related (group A) and 22 (12.2%) virus-unrelated cirrhosis (group B). We analyzed patient characteristics including demographics, tumor features, downstaging treatments, and recurrences. Results: At a mean follow-up of 41.2 months, the 3- and 5-year overall long-term survivals between group A versus group B were 81% versus 75% and 85% versus 78.4% respectively (P = NS). The 3- and 5-year disease-free survivals between group A versus group B were 90.8% versus 89.6% and 85.6% versus 85.6%, respectively (P = NS). After OLT, HCC recurrences occurred in 14 group A (14/157, 8.9%) and 4 patients (4/22, 18.1%) group B subjects. Discussion: Our data demonstrated that after OLT, HCC outcomes were not different between patients with virus-related or -unrelated cirrhosis. The direct oncogenetic role played by hepatitis B and C appear to not be associated with a greater risk to develop HCC recurrence. © 2010 Elsevier Inc. All rights reserved

Published
2010

39. Living Donor Liver Transplantation for Hepatocellular Carcinoma: Long-Term Results Compared With Deceased Donor Liver Transplantation

Author

Di Sandro, S, Slim, A, Giacomoni, A, Lauterio, A, Mangoni, I, Aseni, P, Pirotta, V, Aldumour, A, Mihaylov, P, De Carlis, L, Di Sandro, S., Slim, A. O., Giacomoni, A., Lauterio, A., Mangoni, I., Aseni, P., Pirotta, V., Aldumour, A., Mihaylov, P., De Carlis, L., Di Sandro, S, Slim, A, Giacomoni, A, Lauterio, A, Mangoni, I, Aseni, P, Pirotta, V, Aldumour, A, Mihaylov, P, De Carlis, L, Di Sandro, S., Slim, A. O., Giacomoni, A., Lauterio, A., Mangoni, I., Aseni, P., Pirotta, V., Aldumour, A., Mihaylov, P., and De Carlis, L.

Abstract

Objective: Living donor liver transplantation (LDLT) may represent a valid therapeutic option allowing several advantages for patients affected by hepatocellular carcinoma (HCC) awaiting orthotopic liver transplantation (OLT). However, some reports in the literature have demonstrated worse long-term and disease-free survivals among patients treated by LDLT than deceased donor liver transplantation (DDLT) for HCC. Herein we have reported our long-term results comparing LDLT with DDLT for HCC. Patients and Methods: Among 179 patients who underwent OLT from January 2000 to December 2007, 25 (13.9%) received LDLT with HCC 154 (86.1%) received DDLT. Patients were selected based on the Milan criteria. Transarterial chemoembolization, radiofrequency ablation, percutaneous alcoholization, or liver resection was applied as a downstaging procedure while on the waiting list. Patients with stage II HCC were proposed for LDLT. Results: The overall 3- and 5-year survival rates were 77.3% and 68.7% versus 82.8% and 76.7% for LDLT and DDLT recipients, respectively, with no significant difference by the log-rank test. Moreover, the 3- and 5-year recurrence-free survival rates were 95.5% and 95.5% (LDLT) versus 90.5% and 89.4% (DDLT; P = NS). Conclusions: LDLT guarantees the same long-term results as DDLT where there are analogous selection criteria for candidates. The Milan criteria remain a valid tool to select candidates for LDLT to achieve optimal long-term results. © 2009 Elsevier Inc. All rights reserved

Published
2009

40. Liver Adenomatosis: A Rare Indication for Living Donor Liver Transplantation

Author

Di Sandro, S, Slim, A, Lauterio, A, Giacomoni, A, Mangoni, I, Aseni, P, Pirotta, V, Aldumour, A, Mihaylov, P, De Carlis, L, Di Sandro, S., Slim, A. O., Lauterio, A., Giacomoni, A., Mangoni, I., Aseni, P., Pirotta, V., Aldumour, A., Mihaylov, P., De Carlis, L., Di Sandro, S, Slim, A, Lauterio, A, Giacomoni, A, Mangoni, I, Aseni, P, Pirotta, V, Aldumour, A, Mihaylov, P, De Carlis, L, Di Sandro, S., Slim, A. O., Lauterio, A., Giacomoni, A., Mangoni, I., Aseni, P., Pirotta, V., Aldumour, A., Mihaylov, P., and De Carlis, L.

Abstract

Liver adenomatosis (LA) is a rare benign disease of the liver with unclear pathogenesis, which is characterized by multiple hepatic adenomas. The management of LA remains controversial. Herein we have reported a case of LA treated by living donor liver transplantation (LDLT). A 48-year-old woman developed multiple liver adenomas. In view of the sizes and localizations of the lesions, the patient underwent right hepatic resection and segment II nodulectomy. Thirty-four months later, she developed recurrence of multiple hepatic adenomas and 2 nodules were highly suspect for hepatocellular carcinoma. Re-resection was not indicated due to the whole liver being involved with adenomas. The patient underwent LDLT. At 45 months thereafter she is alive and disease-free. In conclusion, LDLT is indicated in cases of nonresectability; it may offer optimal results in view of the absence of portal hypertension and the elimination of waiting list time. © 2009 Elsevier Inc. All rights reserved

Published
2009

41. The Un-sustainable Match In Hcv Liver Transplant Patients

Author

Avolio, Aw, Agnes, S, Lirosi, Mc, Salizzoni, Mauro, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Bresadola, F, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Vitale, A, Nicolotti, N, Romagnoli, Renato, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Scuderi, E, Antonelli, B, de Waure, C, Angelico, M, Burra, P, Gasbarrini, A, Cillo, U., Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Bresadola, F, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Vitale, A, Nicolotti, N, Romagnoli, R, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Scuderi, E, Antonelli, B, de Waure, C, Angelico, M, Burra, P, Gasbarrini, A, and Cillo, U

Subjects
Liver transplantation, donor-recipient match, liver transplantation
Published
2012

42. Behind D-MELD: The Role of Primary Indication (HCV or HBV) as Significant Covariate in the Outcome Prediction after Liver Transplants

Author

Avolio AW, Agnes S, Lirosi MC, Salizzoni M, Pinna A, Gridelli B, De Carlis L, Colledan M, Gerunda G, Valente U, Rossi G, Ettorre G, Risaliti A, Mazzaferro V, Rossi M, Tisone G, Zamboni F, Lupo L, Cuomo O, Calise F, Nicolotti N, Vitale A, Romagnoli R, Cucchetti A, Gruttadauria S, Mangoni I, Pinelli D, Montalti R, Gelli M, Caccamo L, Vennarecci G, Nicolini D, Regalia E, Baccarani U, Lai Q, Manzia T, Tondolo E, Rendina M, Perrella A, Scuderi E, Burra P, Gasbarrini A, Cillo U, Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Nicolotti, N, Vitale, A, Romagnoli, R, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Scuderi, E, Burra, P, Gasbarrini, A, and Cillo, U

Subjects
liver transplantation, D-MELD
Published
2012

43. Use of HBcAb Positive Liver Grafts. Medium Term Results According to Donor-Recipient Risk Factors

Author

Avolio, A., Agnes, S., Salizzoni, M., Pinna, A., Gridelli, B., De Carlis, L., Colledan, M., Gerunda, G., Valente, U., Rossi, G., Ettorre, G., Risaliti, A., Mazzaferro, V., Bresadola, F., Rossi, Massimo, Tisone, G., Zamboni, F., Lupo, L., Cuomo, O., Calise, F., Lirosi, M., Vitale, A., Nicolotti, N., Romagnoli, R., Cucchetti, A., Gruttadauria, S., Mangoni, I., Pinelli, D., Montalti, R., Gelli, M., Caccamo, L., Vennarecci, G., Nicolini, D., Regalia, E., Baccarani, U., Lai, Q., Manzia, T., Tondolo, E., Rendina, M., Perrella, A., Scudieri, E., Antonelli, B., de Waure, C., De Feo, T., Burra, P., Gasbarrini, A., Cillo, U., Avolio, A, Agnes, S, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Bresadola, F, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Lirosi, M, Vitale, A, Nicolotti, N, Romagnoli, R, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Scudieri, E, Antonelli, B, de Waure, C, De Feo, T, Burra, P, Gasbarrini, A, and Cillo, U

Subjects
liver transplantation, HBcAb positive donor
Published
2011

44. www.D-MELD.com. THE ONLINE PROGNOSTIC CALCULATOR TO OPTIMIZE DONOR-RECIPIENT MATCH

Author

Avolio, A. W., Agnes, S., Lirosi, M. C., Salizzoni, M., Pinna, A. D., Gridelli, B., Carlis, L. D., Colledan, M., Gerunda, G. E., Valente, U., Rossi, G., Ettorre, G. M., Risaliti, A., Mazzaferro, V., Bresadola, F., Rossi, M., Tisone, G., Zamboni, F., Lupo, L., Cuomo, O., Calise, F., Donataccio, M., Nicolotti, N., Vitale, A., Romagnoli, R., Lupo, F., Cucchetti, A., Gruttadauria, S., Mangoni, I., Pinelli, D., Montalti, R., Gelli, M., Caccamo, L., Vennarecci, G., Nicolini, D., Regalia, E., Baccarani, U., Lai, Q., Manzia, T., Tondolo, E., Rendina, M., Perrella, A., Scuderi, E., Antonelli, B., Waure, C. d., Feo, T. D., Burra, Patrizia, Gasbarrini, A., Cillo, Umberto, Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Bresadola, F, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Donataccio, M, Nicolotti, N, Vitale, A, Romagnoli, R, Lupo, F, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Scuderi, E, Antonelli, B, de Waure, C, De Feo, T, Burra, P, Gasbarrini, A, and Cillo, U

Subjects
Transplantation, liver transplantation, Surgery, D-MELD
Published
2011

45. Technical factors affecting late biliary complications after adult living donor liver transplantation

Author

Lauterio, A, Giacomoni, A, Slim, A, Dorobantu, B, Pulitano, C, Mangoni, I, Mihaylov, P, Pirotta, V, De Gasperi, A, De Carlis, L, Lauterio A, Giacomoni A, Slim A, Dorobantu B, Pulitano C, Mangoni I, Mihaylov P, Pirotta V, De Gasperi A, De Carlis L, Lauterio, A, Giacomoni, A, Slim, A, Dorobantu, B, Pulitano, C, Mangoni, I, Mihaylov, P, Pirotta, V, De Gasperi, A, De Carlis, L, Lauterio A, Giacomoni A, Slim A, Dorobantu B, Pulitano C, Mangoni I, Mihaylov P, Pirotta V, De Gasperi A, and De Carlis L

Published
2007

46. Right hemiliver transplant: Results from living and cadaveric donors

Author

Giacomoni, A, De Carlis, L, Lauterio, A, Slim, A, Aseni, P, Sammartino, C, Mangoni, I, Belli, L, De Gasperi, A, Giacomoni, A., De Carlis, L., Lauterio, A., Slim, A. O., Aseni, P., Sammartino, C., Mangoni, I., Belli, L. S., De Gasperi, A., Giacomoni, A, De Carlis, L, Lauterio, A, Slim, A, Aseni, P, Sammartino, C, Mangoni, I, Belli, L, De Gasperi, A, Giacomoni, A., De Carlis, L., Lauterio, A., Slim, A. O., Aseni, P., Sammartino, C., Mangoni, I., Belli, L. S., and De Gasperi, A.

Abstract

Although right hemiliver transplant from living donors (LD) is gaining acceptance as a way to overcome the critical organ shortage, splitting a liver for two adults from cadaveric donor (CD) is still controversial. Methods. From May 1999 to August 2004 we performed nine right hemiliver transplants using segments 5-6-7-8 from CD and 18 from LD. Results. We compared the two procedures to evaluate both the technical aspects and the patients' outcomes. In the CD group, three recipients died (33%), two of whom were UNOS Status 2A. Patient and graft survivals were 67% (median follow-up: 23 months). Among the LD group, three recipients died (17%) and two were retransplanted; one because of arterial thrombosis and the other as a consequence of small-for-size syndrome. Patient and graft survivals were 83% and 72%, respectively (median follow-up: 8 months). There were five early complications in the CD group (55%) and five (27%) in the LD group. Two patients in the LD group experienced a late stenosis of the biliary anastomosis. Discussion. Data from our early experience show that better results are achieved by right hemiliver transplants from LD; the morbidity and mortality are higher among the CD group. We believe that this finding is probably a consequence of better preoperative donor evaluation, shorter ischemia time, better logistics, and learning curve. Recipient selection is crucial; this kind of graft is at high risk of poor function, technical complications, and infections. Further experience will help to clarify the reliability of right hemiliver transplants from CD. © 2005 by Elsevier Inc. All rights reserved

Published
2005

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