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770 results on '"Manger, Bernhard"'

1. Befragung zu den Arbeits-, Weiterbildungs- und Forschungsbedingungen von Assistenzärztinnen und -ärzten in der internistisch-rheumatologischen Weiterbildung – BEWUSST

Author

Proft, Fabian, Vossen, Diana, Baraliakos, Xenofon, Berliner, Michael N., Fleck, Martin, Keyßer, Gernot, Krause, Andreas, Lorenz, Hanns-Martin, Manger, Bernhard, Schuch, Florian, Specker, Christof, Wollenhaupt, Jürgen, Voormann, Anna, Raspe, Matthias, Krusche, Martin, and Pfeil, Alexander

Published
2024
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3. Rheumatologische Weiterbildungsstellen in Deutschland

Author

Pfeil, Alexander, Krusche, Martin, Proft, Fabian, Vossen, Diana, Braun, Jürgen, Baraliakos, Xenofon, Berliner, Michael N., Keyßer, Gernot, Krause, Andreas, Lorenz, Hanns-Martin, Manger, Bernhard, Schuch, Florian, Specker, Christof, Wollenhaupt, Jürgen, Voormann, Anna, and Fleck, Martin

Published
2023
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21. Abatacept inhibits inflammation and onset of rheumatoid arthritis in individuals at high risk (ARIAA): a randomised, international, multicentre, double-blind, placebo-controlled trial

Author

Rech, Juergen, Tascilar, Koray, Hagen, Melanie, Kleyer, Arnd, Manger, Bernhard, Schoenau, Verena, Hueber, Axel J, Kleinert, Stefan, Baraliakos, Xenofon, Braun, Jürgen, Kiltz, Uta, Fleck, Martin, Rubbert-Roth, Andrea, Kofler, David M, Behrens, Frank, Feuchtenberger, Martin, Zaenker, Michael, Voll, Reinhard, Venhoff, Nils, Thiel, Jens, Glaser, Cornelia, Feist, Eugen, Burmester, Gerd R, Karberg, Kirsten, Strunk, Johannes, Cañete, Juan D, Senolt, Ladislav, Filkova, Maria, Naredo, Esperanza, Largo, Raquel, Krönke, Gerhard, D'Agostino, Maria-Antonietta, Østergaard, Mikkel, and Schett, Georg

Published
2024
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24. Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) consensus statement regarding labels and definitions of disease states of gout

Author

Bursill, David, Taylor, William J, Terkeltaub, Robert, Abhishek, Abhishek, So, Alexander K, Vargas-Santos, Ana Beatriz, Gaffo, Angelo Lino, Rosenthal, Ann, Tausche, Anne-Kathrin, Reginato, Anthony, Manger, Bernhard, Sciré, Carlo, Pineda, Carlos, van Durme, Caroline, Lin, Ching-Tsai, Yin, Congcong, Albert, Daniel Arthur, Biernat-Kaluza, Edyta, Roddy, Edward, Pascual, Eliseo, Becce, Fabio, Perez-Ruiz, Fernando, Sivera, Francisca, Lioté, Frédéric, Schett, Georg, Nuki, George, Filippou, Georgios, McCarthy, Geraldine, da Rocha Castelar Pinheiro, Geraldo, Ea, Hang-Korng, De Almeida Tupinambá, Helena, Yamanaka, Hisashi, Choi, Hyon K, Mackay, James, ODell, James R, Mellado, Janitzia Vázquez, Singh, Jasvinder A, Fitzgerald, John D, Jacobsson, Lennart TH, Joosten, Leo, Harrold, Leslie R, Stamp, Lisa, Andrés, Mariano, Gutierrez, Marwin, Kuwabara, Masanari, Dehlin, Mats, Janssen, Matthijs, Doherty, Michael, Hershfield, Michael S, Pillinger, Michael, Edwards, N Lawrence, Schlesinger, Naomi, Kumar, Nitin, Slot, Ole, Ottaviani, Sebastien, Richette, Pascal, MacMullan, Paul A, Chapman, Peter T, Lipsky, Peter E, Robinson, Philip, Khanna, Puja P, Gancheva, Rada N, Grainger, Rebecca, Johnson, Richard J, Kampe, Ritch Te, Keenan, Robert T, Tedeschi, Sara K, Kim, Seoyoung, Choi, Sung Jae, Fields, Theodore R, Bardin, Thomas, Uhlig, Till, Jansen, Tim, Merriman, Tony, Pascart, Tristan, Neogi, Tuhina, Klück, Viola, Louthrenoo, Worawit, and Dalbeth, Nicola

Subjects
Arthritis, Inflammatory and immune system, Consensus, Gout, Humans, Hyperuricemia, Terminology as Topic, gout, hyperuricemia, language, monosodium urate crystals, nomenclature, terminology, urate, Clinical Sciences, Immunology, Public Health and Health Services, Arthritis & Rheumatology
Abstract

ObjectiveThere is a lack of standardisation in the terminology used to describe gout. The aim of this project was to develop a consensus statement describing the recommended nomenclature for disease states of gout.MethodsA content analysis of gout-related articles from rheumatology and general internal medicine journals published over a 5-year period identified potential disease states and the labels commonly assigned to them. Based on these findings, experts in gout were invited to participate in a Delphi exercise and face-to-face consensus meeting to reach agreement on disease state labels and definitions.ResultsThe content analysis identified 13 unique disease states and a total of 63 unique labels. The Delphi exercise (n=76 respondents) and face-to-face meeting (n=35 attendees) established consensus agreement for eight disease state labels and definitions. The agreed labels were as follows: 'asymptomatic hyperuricaemia', 'asymptomatic monosodium urate crystal deposition', 'asymptomatic hyperuricaemia with monosodium urate crystal deposition', 'gout', 'tophaceous gout', 'erosive gout', 'first gout flare' and 'recurrent gout flares'. There was consensus agreement that the label 'gout' should be restricted to current or prior clinically evident disease caused by monosodium urate crystal deposition (gout flare, chronic gouty arthritis or subcutaneous tophus).ConclusionConsensus agreement has been established for the labels and definitions of eight gout disease states, including 'gout' itself. The Gout, Hyperuricaemia and Crystal-Associated Disease Network recommends the use of these labels when describing disease states of gout in research and clinical practice.

Published
2019

25. Intensity and longevity of SARS-CoV-2 vaccination response in patients with immune-mediated inflammatory disease: a prospective cohort study

Author

Simon, David, Tascilar, Koray, Fagni, Filippo, Kleyer, Arnd, Krönke, Gerhard, Meder, Christine, Dietrich, Peter, Orlemann, Till, Mößner, Johanna, Taubmann, Jule, Mutlu, Melek Yalcin, Knitza, Johannes, Kemenes, Stephan, Liphardt, Anna-Maria, Schönau, Verena, Bohr, Daniela, Schuster, Louis, Hartmann, Fabian, Minopoulou, Ioanna, Leppkes, Moritz, Ramming, Andreas, Pachowsky, Milena, Schuch, Florian, Ronneberger, Monika, Kleinert, Stefan, Hueber, Axel J, Manger, Karin, Manger, Bernhard, Atreya, Raja, Berking, Carola, Sticherling, Michael, Neurath, Markus F, and Schett, Georg

Published
2022
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29. Treatment tapering and stopping in patients with rheumatoid arthritis in stable remission (RETRO): a multicentre, randomised, controlled, open-label, phase 3 trial

Author

Tascilar, Koray, Hagen, Melanie, Kleyer, Arnd, Simon, David, Reiser, Michaela, Hueber, Axel J, Manger, Bernhard, Englbrecht, Matthias, Finzel, Stephanie, Tony, Hans-Peter, Schuch, Florian, Kleinert, Stefan, Wendler, Joerg, Ronneberger, Monika, Figueiredo, Camille P, Cobra, Jayme F, Feuchtenberger, Martin, Fleck, Martin, Manger, Karin, Ochs, Wolfgang, Schmitt-Haendle, Matthias, Lorenz, Hanns-Martin, Nuesslein, Hubert, Alten, Rieke, Kruger, Klaus, Henes, Joerg, Schett, Georg, and Rech, Juergen

Published
2021
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36. Tixagevimab/cilgavimab for the prevention of COVID-19 in vaccine-refractory patients with autoimmune diseases: a prospective cohort study.

Author

Minopoulou, Ioanna, Tascilar, Koray, Corte, Giulia, Mutlu, Melek Yalcin, Schmidt, Katja, Bohr, Daniela, Hartmann, Fabian, Manger, Karin, Manger, Bernhard, Korn, Klaus, Kleyer, Arnd, Simon, David, Harrer, Thomas, Schett, Georg, and Fagni, Filippo

Subjects
SALIVA analysis, THERAPEUTIC use of monoclonal antibodies, IMMUNOGLOBULIN analysis, RISK assessment, IMMUNIZATION, RESEARCH funding, DRUG resistance in microorganisms, IMMUNOGLOBULINS, DESCRIPTIVE statistics, LONGITUDINAL method, ODDS ratio, MONOCLONAL antibodies, AUTOIMMUNE diseases, CONFIDENCE intervals, COVID-19, IMMUNOLOGIC diseases, DISEASE incidence, DISEASE risk factors
Abstract

Objectives To investigate the effects of passive immunization with the anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) monoclonal antibodies tixagevimab/cilgavimab on humoral responses and on coronavirus disease 2019 (COVID-19) outcomes in vaccine-refractory patients with immune-mediated inflammatory diseases (IMIDs) at high risk of severe COVID-19. Methods A prospective cohort study was performed on a cohort of high-risk vaccine-refractory IMID patients treated with a single dose of tixagevimab/cilgavimab (150 mg/150 mg). COVID-19 outcomes as well as serum and salivary anti-SARS-CoV-2 IgG were assessed at baseline and for at least 6 months. Results were compared with an untreated high-risk vaccine-refractory IMID population. Standardized incidence ratios (SIRs) of COVID-19 compared with the general population were calculated for both groups. Results A total of 38 high-risk IMID patients received tixagevimab/cilgavimab and were compared with 114 untreated high-risk IMID controls. Serum anti-spike IgG increased to 6.6 OD (s. d. 0.8) at day 1 and remained positive up to month 6 [6.3 OD (s. d. 1.4)]. Salivary anti-spike IgG peaked at month 2 [1.6 OD (s. d. 1.1)] and decreased from month 3 [0.8 OD (s. d. 0.3)]. No severe or extended infection was observed in the tixagevimab/cilgavimab group. Compared with the general population, the SIR of COVID-19 in treated patients was 0.76 (95% CI 0.24, 1.58) despite the increased risk profile. The SIR of the control group was 1.51 (95% CI 1.07, 2.02), corresponding to a significantly increased incidence. Conclusions Passive immunization with tixagevimab/cilgavimab is safe and effective in inducing anti-SARS-CoV-2 immunity and potentially in preventing COVID-19 in high-risk vaccine-refractory IMID patients. These data provide a proof of concept for the use of monoclonal antibodies as a preventative strategy against SARS-CoV-2 in vulnerable populations. [ABSTRACT FROM AUTHOR]

Published
2024
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38. Tixagevimab/cilgavimab for the prevention of COVID-19 in vaccine-refractory patients with autoimmune diseases: a prospective cohort study

Author

Minopoulou, Ioanna, primary, Tascilar, Koray, additional, Corte, Giulia, additional, Mutlu, Melek Yalcin, additional, Schmidt, Katja, additional, Bohr, Daniela, additional, Hartmann, Fabian, additional, Manger, Karin, additional, Manger, Bernhard, additional, Korn, Klaus, additional, Kleyer, Arnd, additional, Simon, David, additional, Harrer, Thomas, additional, Schett, Georg, additional, and Fagni, Filippo, additional

Published
2023
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39. Patients with immune-mediated inflammatory diseases receiving cytokine inhibitors have low prevalence of SARS-CoV-2 seroconversion

Author

Simon, David, Tascilar, Koray, Krönke, Gerhard, Kleyer, Arnd, Zaiss, Mario M., Heppt, Franz, Meder, Christine, Atreya, Raja, Klenske, Entcho, Dietrich, Peter, Abdullah, Abdullah, Kliem, Thorsten, Corte, Giulia, Morf, Harriet, Leppkes, Moritz, Kremer, Andreas E., Ramming, Andreas, Pachowsky, Milena, Schuch, Florian, Ronneberger, Monika, Kleinert, Stefan, Maier, Clara, Hueber, Axel J., Manger, Karin, Manger, Bernhard, Berking, Carola, Tenbusch, Matthias, Überla, Klaus, Sticherling, Michael, Neurath, Markus F., and Schett, Georg

Published
2020
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40. Physical Function of RA patients Tapering Treatment—A Post Hoc Analysis of the Randomized Controlled RETRO Trial

Author

Stephan, Marlene, primary, Tascilar, Koray, additional, Yalcin-Mutlu, Melek, additional, Hagen, Melanie, additional, Haschka, Judith, additional, Reiser, Michaela, additional, Hartmann, Fabian, additional, Kleyer, Arnd, additional, Hueber, Axel J., additional, Manger, Bernhard, additional, Figueiredo, Camille, additional, Cobra, Jayme Fogagnolo, additional, Tony, Hans-Peter, additional, Finzel, Stephanie, additional, Kleinert, Stefan, additional, Wendler, Jörg, additional, Schuch, Florian, additional, Ronneberger, Monika, additional, Feuchtenberger, Martin, additional, Fleck, Martin, additional, Manger, Karin, additional, Ochs, Wolfgang, additional, Schmitt-Haendle, Matthias, additional, Lorenz, Hannes Martin, additional, Nüsslein, Hubert, additional, Alten, Rieke, additional, Henes, Joerg, additional, Krüger, Klaus, additional, Schett, Georg, additional, and Rech, Jürgen, additional

Published
2023
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41. CD19-targeted CAR T cells in refractory antisynthetase syndrome

Author

Müller, Fabian, primary, Boeltz, Sebastian, additional, Knitza, Johannes, additional, Aigner, Michael, additional, Völkl, Simon, additional, Kharboutli, Soraya, additional, Reimann, Hannah, additional, Taubmann, Jule, additional, Kretschmann, Sascha, additional, Rösler, Wolf, additional, Manger, Bernhard, additional, Wacker, Jochen, additional, Mougiakakos, Dimitrios, additional, Jabari, Samir, additional, Schröder, Rolf, additional, Uder, Michael, additional, Roemer, Frank, additional, Krönke, Gerhard, additional, Mackensen, Andreas, additional, and Schett, Georg, additional

Published
2023
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46. Rheumatologische Weiterbildungsstellen in Deutschland

Author

Pfeil, Alexander, primary, Krusche, Martin, additional, Proft, Fabian, additional, Vossen, Diana, additional, Braun, Jürgen, additional, Baraliakos, Xenofon, additional, Berliner, Michael N., additional, Keyßer, Gernot, additional, Krause, Andreas, additional, Lorenz, Hanns-Martin, additional, Manger, Bernhard, additional, Schuch, Florian, additional, Specker, Christof, additional, Wollenhaupt, Jürgen, additional, Voormann, Anna, additional, and Fleck, Martin, additional

Published
2022
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