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111 results on '"Manganoni, A. M."'

4. Dermoscopy of scalp tumours: a multi-centre study conducted by the international dermoscopy society

Author

Stanganelli, I., Argenziano, G., Sera, F., Blum, A., Ozdemir, F., Karaarslan, I. K., Piccolo, D., Peris, K., Kirchesch, H., Bono, R., Pizzichetta, M. A., Gasparini, S., Braun, R. P., Correia, O., Thomas, L., Zaballos, P., Puig, S., Malvehy, J., Scalvenzi, M., Rabinovitz, H., Bergamo, A., Pellacani, G., Longo, C., Pavlovic, M., Rosendahl, C., Hofmann-Wellenhof, R., Cabo, H., Marghoob, A. A., Langford, D., Astorino, S., Manganoni, A. M., Gourhant, J.-Y., Keir, J., Grichnik, J. M., Fumo, G., Dong, H., Rachou, Sortino A.M., Ferrara, G., and Zalaudek, I.

Published
2012
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12. Lupus miliaris disseminatus faciei in a young male

Author

Manganoni, Ausilia M., primary, Farisoglio, Camillo, additional, Pavoni, Laura, additional, Chiudinelli, Mariella, additional, Stillitano, Giuseppe, additional, Ungari, Marco, additional, and Calzavara-Pinton, Piergiacomo, additional

Published
2019
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13. Genetic counselling and high-penetrance susceptibility gene analysis reveal the novel CDKN2A p.D84V (c.251A>T) mutation in melanoma-prone families from Italy

Author

Borroni, Riccardo G., primary, Manganoni, Ausilia M., additional, Grassi, Sara, additional, Grasso, Maurizia, additional, Diegoli, Marta, additional, Giorgianni, Carmela, additional, Favalli, Valentina, additional, Pavoni, Laura, additional, Cespa, Maddalena, additional, and Arbustini, Eloisa, additional

Published
2017
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14. Melanoma in the elderly

Author

Manganoni, Ausilia M., primary, Pizzatti, Laura, additional, Pavoni, Laura, additional, Consoli, Francesca, additional, Damiani, Enrico, additional, Manca, Giorgio, additional, Gualdi, Giulio, additional, and Calzavara-Pinton, Piergiacomo, additional

Published
2017
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16. Dermoscopy of scalp tumours: a multi-centre study conducted by the international dermoscopy society

Author

Stanganelli, I, Argenziano, G, Sera, F, Blum, A, Ozdemir, F, Karaarslan, I K, Piccolo, D, Peris, K, Kirchesch, H, Bono, R, Pizzichetta, M A, Gasparini, S, Braun, R P, Correira, O, Thomas, L, Zaballos, P, Puig, S, Malvehy, J, Scalvenzi, M, Rabinovitz, H, Bergamo, A, Pellacani, G, Longo, C, Pavlovic, M, Rosendahl, C, Hofmann-Wellenhof, R, Cabo, H, Marghoob, A A, Langford, D, Astorino, S, Manganoni, A M, Gourhant, J Y, Keir, J, Grichnik, J M, Fumo, G, Dong, H, Sortino Rachou, A M, Ferrara, G, Zalaudek, I, Stanganelli, I, Argenziano, G, Sera, F, Blum, A, Ozdemir, F, Karaarslan, Ik, Piccolo, D, Peris, K, Kirchesch, H, Bono, R, Pizzichetta, Ma, Gasparini, S, Braun, Rp, Correira, O, Thomas, L, Zaballos, P, Puig, S, Malvehy, J, Scalvenzi, Massimiliano, Rabinovitz, H, Bergamo, A, Pellacani, G, Longo, C, Pavlovic, M, Rosendahl, C, Hofmann Wellenhof, R, Cabo, H, Marghoob, Aa, Langford, D, Astorino, S, Manganoni, Am, Gourhant, Jy, Keir, J, Grichnik, Jm, Fumo, G, Dong, H, Sortino Rachou, Am, Ferrara, G, Zalaudek, I., Correia, O, Scalvenzi, M, Hofmann-Wellenhof, R, Zalaudek, I, Argenziano, Giuseppe, Gourhant, J. Y., and University of Zurich

Subjects
Adult, Male, Scalp, Adolescent, 10177 Dermatology Clinic, 610 Medicine & health, Dermoscopy, 2725 Infectious Diseases, Middle Aged, 2708 Dermatology, Young Adult, Infectious Diseases, Aged, Child, Child, Preschool, Female, Humans, Retrospective Studies, Retrospective Studie, Settore MED/35 - MALATTIE CUTANEE E VENEREE, Preschool, Human
Abstract

Little is known about the dermoscopic features of scalp tumours. Objective To determine the dermoscopic features of scalp tumours. METHODS: Retrospective analysis of dermoscopic images of histopathologically diagnosed scalp tumours from International Dermoscopy Society members. RESULTS: A total of 323 tumours of the scalp from 315 patients (mean age: 52 years; range 3-88 years) were analysed. Scalp nevi were significantly associated with young age (65 years and sun damage. Atypical network and regression were predictive for thin (≤1 mm) melanomas, whereas advanced melanomas (tumour thickness > 1 mm) revealed blue white veil, unspecific patterns and irregular black blotches or dots. CONCLUSIONS: The data collected provide a new knowledge regarding the clinical and dermoscopy features of pigmented scalp tumours

Published
2012

24. Dermatofibrosarcoma Protuberans in an Adolescent

Author

Manganoni, Ausilia M., primary, Pavoni, Laura, additional, Gualdi, Giulio, additional, Marocolo, Daniela, additional, Chiudinelli, Mariella, additional, Sereni, Elena, additional, Farisoglio, Camillo, additional, and Calzavara-Pinton, Piergiacomo, additional

Published
2013
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26. Genetic counselling and high-penetrance susceptibility gene analysis reveal the novel CDKN2Ap.D84V (c.251A>T) mutation in melanoma-prone families from Italy

Author

Borroni, Riccardo G., Manganoni, Ausilia M., Grassi, Sara, Grasso, Maurizia, Diegoli, Marta, Giorgianni, Carmela, Favalli, Valentina, Pavoni, Laura, Cespa, Maddalena, and Arbustini, Eloisa

Abstract

Genetic susceptibility to primary cutaneous melanoma (PCM) may account for up to 12% of PCMs, presenting as the familial atypical mole/multiple melanoma syndrome (FAMMM), an autosomal dominant condition with incomplete penetrance and variable expressivity, characterized by PCM in at least two relatives and/or more than one PCMs in the same patient. To identify individuals at high genetic risk of PCM, from 1 January 2012 to 31 December 2015, we offered genetic counselling and molecular analysis of the two high-penetrance FAMMM susceptibility genes, cyclin-dependent kinase inhibitor 2A (CDKN2A) and cyclin-dependent kinase 4 (CDK4), to 92 consecutive, unrelated patients with FAMMM. Age at diagnosis and number of PCMs were obtained from medical records; the number of PCMs and affected relatives were recorded for each family. The diagnostic work-up consisted of genetic counselling and cascade genetic testing in patients and further extension to relatives of those identified as mutation carriers. All exons and exon/intron boundaries of CDKN2Aand CDK4genes were screened by direct bidirectional sequencing. We identified CDKN2Amutations in 19 of the 92 unrelated patients (20.6%) and in 14 additional, clinically healthy relatives. Eleven of these latter subsequently underwent excision of dysplastic nevi, but none developed PCM during a median follow-up of 37.3 months. In three patients from unrelated families, the novel CDKN2Ap.D84V (c.251A>T) mutation was observed, associated with PCM in each pedigree. Genetic screening of FAMMM patients and their relatives can contribute towards specific primary and secondary prevention programmes for individuals at high genetic risk of PCM. The novel CDKN2Ap.D84V (c.251A>T) mutation adds to the known mutations associated with FAMMM.

Published
2017
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28. Desmoplastic Melanoma: Report of 5 Cases

Author

Manganoni, A. M., primary, Farisoglio, C., additional, Bassissi, S., additional, Braga, D., additional, Facchetti, F., additional, Ungari, M., additional, and Calzavara-Pinton, P. G., additional

Published
2009
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31. Diverse expansion potential and heterogeneous avidity in tumor-associated antigen-specific T lymphocytes from primary melanoma patients

Author

Palermo, Belinda, primary, Campanelli, Rita, additional, Mantovani, Stefania, additional, Lantelme, Erica, additional, Manganoni, Ausilia M., additional, Carella, Graziella, additional, Da Prada, GianAntonio, additional, della Cuna, Gioacchino Robustelli, additional, Romagne, François, additional, Gauthier, Laurent, additional, Necker, Antje, additional, and Giachino, Claudia, additional

Published
2001
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34. Follow-up of cutaneous melanoma patients: A proposal for standardization

Author

Moscarella, E., Ricci, C., Borgognoni, L., Bottoni, U., Catricalà, C., Dika, E., Fanti, P. A., Landi, C., Manganoni, A. M., Giovanni Pellacani, Peris, K., Pimpinelli, N., Quaglino, P., Richetta, A., Simonetti, V., Stanganelli, I., Testori, A., Zalaudek, I., Argenziano, G., Moscarella, E, Ricci, C, Borgognoni, L, Bottoni, U, Catricalà, C, Dika, E, Fanti, Pa, Landi, C, Manganoni, Am, Pellacani, G, Peris, K, Pimpinelli, N, Quaglino, P, Richetta, A, Simonetti, V, Stanganelli, I, Testori, A, Zalaudek, I, Argenziano, Giuseppe, Fanti, P A, Manganoni, A M, and Argenziano, G

Subjects
Skin Neoplasms, Follow-Up Studies, Humans, Melanoma, Practice Guidelines as Topic, Reference Standards, melanoma, follow-up, Follow-Up Studie, melanoma, follow-up, Reference Standard, Human
Abstract

not available

36. [Immunohistochemical study of porokeratosis in kidney transplantation]

Author

Manganoni, A. M., Fabio FACCHETTI, Manganoni, A., and Gavazzoni, R.

Subjects
Male, Postoperative Complications, Clone Cells, Dendritic Cells, Disease Susceptibility, Female, Humans, Immunosuppressive Agents, Keratosis, Langerhans Cells, Kidney Transplantation
Abstract

Six cases of disseminated actinic superficial porokeratosis are reported in kidney transplant recipients. Immunohistochemistry study showed an altered state of Langerhans cell surface markers at the level of the cutaneous lesions of porokeratosis. We can hypothesize that the alterate state of epidermal dendritic cells in porokeratosis contributes to the development of abnormal clones of keratinocytes.

Published
1989

44. MC1R variants in childhood and adolescent melanoma: a retrospective pooled analysis of a multicentre cohort

Author

Pellegrini, Cristina, Botta, Francesca, Massi, Daniela, Martorelli, Claudia, Facchetti, Fabio, Gandini, Sara, Maisonneuve, Patrick, Avril, Marie-Françoise, Demenais, Florence, Bressac-de Paillerets, Brigitte, Hoiom, Veronica, Cust, Anne E, Anton-Culver, Hoda, Gruber, Stephen B, Gallagher, Richard P, Marrett, Loraine, Zanetti, Roberto, Dwyer, Terence, Thomas, Nancy E, Begg, Colin B, Berwick, Marianne, Puig, Susana, Potrony, Miriam, Nagore, Eduardo, Ghiorzo, Paola, Menin, Chiara, Manganoni, Ausilia Maria, Rodolfo, Monica, Brugnara, Sonia, Passoni, Emanuela, Sekulovic, Lidija Kandolf, Baldini, Federica, Guida, Gabriella, Stratigos, Alexandros, Ozdemir, Fezal, Ayala, Fabrizio, Fernandez-de-Misa, Ricardo, Quaglino, Pietro, Ribas, Gloria, Romanini, Antonella, Migliano, Emilia, Stanganelli, Ignazio, Kanetsky, Peter A, Pizzichetta, Maria Antonietta, García-Borrón, Jose Carlos, Nan, Hongmei, Landi, Maria Teresa, Little, Julian, Newton-Bishop, Julia, Sera, Francesco, Fargnoli, Maria Concetta, Raimondi, Sara, Alaibac, Mauro, Ferrari, Andrea, Valeri, Barbara, Sicher, Mariacristina, Mangiola, Daniela, Nazzaro, Gianluca, Tosti, Giulio, Mazzarol, Giovanni, Giudice, Giuseppe, Ribero, Simone, Astrua, Chiara, Mazzoni, Laura, Orlow, Irene, Mujumdar, Urvi, Hummer, Amanda, Busam, Klaus, Roy, Pampa, Canchola, Rebecca, Clas, Brian, Cotignola, Javiar, Monroe, Yvette, Armstrong, Bruce, Kricker, Anne, Litchfield, Melisa, Tucker, Paul, Stephens, Nicola, Switzer, Teresa, Theis, Beth, From, Lynn, Chowdhury, Noori, Vanasse, Louise, Purdue, Mark, Northrup, David, Rosso, Stefano, Sacerdote, Carlotta, Leighton, Nancy, Gildea, Maureen, Bonner, Joe, Jeter, Joanne, Klotz, Judith, Wilcox, Homer, Weiss, Helen, Millikan, Robert, Mattingly, Dianne, Player, Jon, Tse, Chiu-Kit, Rebbeck, Timothy, Walker, Amy, Panossian, Saarene, Setlow, Richard, Mohrenweiser, Harvey, Autier, Philippe, Han, Jiali, Caini, Saverio, Hofman, Albert, Kayser, Manfred, Liu, Fan, Nijsten, Tamar, Uitterlinden, Andre G., Kumar, Rajiv, Bishop, Tim, Elliott, Faye, Lazovich, Deann, Polsky, David, Hansson, Johan, Pastorino, Lorenza, Gruis, Nelleke A., Bouwes Bavinck, Jan Nico, Aguilera, Paula, Badenas, Celia, Carrera, Cristina, Gimenez-Xavier, Pol, Malvehy, Josep, Puig-Butille, Joan Anton, Tell-Marti, Gemma, Blizzard, Leigh, Cochrane, Jennifer, Branicki, Wojciech, Debniak, Tadeusz, Morling, Niels, Johansen, Peter, Mayne, Susan, Bale, Allen, Cartmel, Brenda, Ferrucci, Leah, Pfeiffer, Ruth, Palmieri, Giuseppe, Kypreou, Katerina, Bowcock, Anne, Cornelius, Lynn, Council, M. Laurin, Motokawa, Tomonori, Anno, Sumiko, Helsing, Per, Andresen, Per Arne, Guida, Stefania, Wong, Collaborators (98): Alaibac M, Terence H., Ferrari, A, Valeri, B, Et, Al., Pellegrini, C., Botta, F., Massi, D., Martorelli, C., Facchetti, F., Gandini, S., Maisonneuve, P., Avril, M. -F., Demenais, F., Bressac-de Paillerets, B., Hoiom, V., Cust, A. E., Anton-Culver, H., Gruber, S. B., Gallagher, R. P., Marrett, L., Zanetti, R., Dwyer, T., Thomas, N. E., Begg, C. B., Berwick, M., Puig, S., Potrony, M., Nagore, E., Ghiorzo, P., Menin, C., Manganoni, A. M., Rodolfo, M., Brugnara, S., Passoni, E., Sekulovic, L. K., Baldini, F., Guida, G., Stratigos, A., Ozdemir, F., Ayala, F., Fernandez-de-Misa, R., Quaglino, P., Ribas, G., Romanini, A., Migliano, E., Stanganelli, I., Kanetsky, P. A., Pizzichetta, M. A., Garcia-Borron, J. C., Nan, H., Landi, M. T., Little, J., Newton-Bishop, J., Sera, F., Fargnoli, M. C., Raimondi, S., Alaibac, M., Ferrari, A., Valeri, B., Sicher, M., Mangiola, D., Nazzaro, G., Tosti, G., Mazzarol, G., Giudice, G., Ribero, S., Astrua, C., Mazzoni, L., Orlow, I., Mujumdar, U., Hummer, A., Busam, K., Roy, P., Canchola, R., Clas, B., Cotignola, J., Monroe, Y., Armstrong, B., Kricker, A., Litchfield, M., Tucker, P., Stephens, N., Switzer, T., Theis, B., From, L., Chowdhury, N., Vanasse, L., Purdue, M., Northrup, D., Rosso, S., Sacerdote, C., Leighton, N., Gildea, M., Bonner, J., Jeter, J., Klotz, J., Wilcox, H., Weiss, H., Millikan, R., Mattingly, D., Player, J., Tse, C. -K., Rebbeck, T., Walker, A., Panossian, S., Setlow, R., Mohrenweiser, H., Autier, P., Han, J., Caini, S., Hofman, A., Kayser, M., Liu, F., Nijsten, T., Uitterlinden, A. G., Kumar, R., Bishop, T., Elliott, F., Lazovich, D., Polsky, D., Hansson, J., Pastorino, L., Gruis, N. A., Bouwes Bavinck, J. N., Aguilera, P., Badenas, C., Carrera, C., Gimenez-Xavier, P., Malvehy, J., Puig-Butille, J. A., Tell-Marti, G., Blizzard, L., Cochrane, J., Branicki, W., Debniak, T., Morling, N., Johansen, P., Mayne, S., Bale, A., Cartmel, B., Ferrucci, L., Pfeiffer, R., Palmieri, G., Kypreou, K., Bowcock, A., Cornelius, L., Council, M. L., Motokawa, T., Anno, S., Helsing, P., Andresen, P. A., Guida, S., Wong, T. H., Ege Üniversitesi, Epidemiology, Genetic Identification, and Dermatology

Subjects
Male, Skin Neoplasms, Pediatrics, Cohort Studies, 0302 clinical medicine, Odds Ratio, Developmental and Educational Psychology, Pediatrics, Perinatology and Child Health, 030212 general & internal medicine, Child, Cancer, Pediatric, Tumor, childhood disease, Middle Aged, Perinatology and Child Health, cohort analysis, Meta-analysis, Melanocortin, Cohort, Female, MC1R gene, Receptor, Melanocortin, Type 1, Receptor, Type 1, Cohort study, Adult, medicine.medical_specialty, adolescent, melanoma, cohort analysi, Subgroup analysis, Article, 03 medical and health sciences, Genetic, Clinical Research, 030225 pediatrics, Internal medicine, Genetics, Biomarkers, Tumor, medicine, Humans, Genetic Predisposition to Disease, Polymorphism, Germ-Line Mutation, Aged, Retrospective Studies, Polymorphism, Genetic, business.industry, Prevention, Case-control study, Retrospective cohort study, GEM Study Group, Odds ratio, Logistic Models, M-SKIP Study Group, Case-Control Studies, Cutaneous melanoma, IMI Study Group, business, Biomarkers
Abstract

Ferrari, Andrea/0000-0002-4724-0517; Pellegrini, Cristina/0000-0003-2168-8097; Migliano, Emilia/0000-0002-5316-8937; Maisonneuve, Patrick/0000-0002-5309-4704; Guida, Stefania/0000-0002-8221-6694; Pastorino, Lorenza/0000-0002-2575-8331; CARRERA, CRISTINA/0000-0003-1608-8820; Paillerets, Brigitte Bressac-de/0000-0003-0245-8608; Sekulovic, Lidija Kandolf/0000-0002-5221-5068; Caini, Saverio/0000-0002-2262-1102; Potrony, Miriam/0000-0003-2766-0765; Pizzichetta, Maria Antonietta/0000-0002-4201-8490; Little, Julian/0000-0001-5026-5531; Nagore, Eduardo/0000-0003-3433-8707; Polsky, David/0000-0001-9554-5289; Demenais, Florence/0000-0001-8361-0936; Nazzaro, Gianluca/0000-0001-8534-6497; gandini, sara/0000-0002-1348-4548; Cornelius, Lynn A/0000-0002-6329-2819; Palmieri, Giuseppe/0000-0002-4350-2276; Cotignola, Javier/0000-0003-4473-9854; Ghiorzo, Paola/0000-0002-3651-8173; Autier, Philippe/0000-0003-1538-5321; Bishop, Tim/0000-0002-8752-8785; Sera, Francesco/0000-0002-8890-6848; Newton-Bishop, Julia/0000-0001-9147-6802; Litchfield, Melisa/0000-0003-0002-7724, WOS: 000464254100018, PubMed: 30872112, Background Germline variants in the melanocortin 1 receptor gene (MC1R) might increase the risk of childhood and adolescent melanoma, but a clear conclusion is challenging because of the low number of studies and cases. We assessed the association of MC1R variants with childhood and adolescent melanoma in a large study comparing the prevalence of MC1R variants in child or adolescent patients with melanoma to that in adult patients with melanoma and in healthy adult controls. Methods in this retrospective pooled analysis, we used the M-SKIP Project, the Italian Melanoma Intergroup, and other European groups (with participants from Australia, Canada, France, Greece, Italy, the Netherlands, Serbia, Spain, Sweden, Turkey, and the USA) to assemble an international multicentre cohort. We gathered phenotypic and genetic data from children or adolescents diagnosed with sporadic single-primary cutaneous melanoma at age 20 years or younger, adult patients with sporadic single-primary cutaneous melanoma diagnosed at age 35 years or older, and healthy adult individuals as controls. We calculated odds ratios (ORs) for childhood and adolescent melanoma associated with MC1R variants by multivariable logistic regression. Subgroup analysis was done for children aged 18 or younger and 14 years or younger. Findings We analysed data from 233 young patients, 932 adult patients, and 932 healthy adult controls. Children and adolescents had higher odds of carrying MC1R r variants than did adult patients (OR 1.54, 95% CI 1.02-2.33), including when analysis was restricted to patients aged 18 years or younger (1.80, 1.06-3.07). All investigated variants, except Arg160Trp, tended, to varying degrees, to have higher frequencies in young patients than in adult patients, with significantly higher frequencies found for Val60Leu (OR 1.60, 95% CI 1.05-2.44; p=0.04) and Asp294His (2.15, 1.05-4.40; p=0.04). Compared with those of healthy controls, young patients with melanoma had significantly higher frequencies of any MC1R variants. Interpretation Our pooled analysis of MC1R genetic data of young patients with melanoma showed that MC1R r variants were more prevalent in childhood and adolescent melanoma than in adult melanoma, especially in patients aged 18 years or younger. Our findings support the role of MC1R in childhood and adolescent melanoma susceptibility, with a potential clinical relevance for developing early melanoma detection and preventive strategies. Copyright (c) 2019 Elsevier Ltd. All rights reserved., [AIRC-MFAG-11831]; NATIONAL CANCER INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) [P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P01CA206980, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P01CA206980, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P01CA206980, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P01CA206980, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P01CA206980, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086] Funding Source: NIH RePORTER, SPD-Pilot/Project-Award-2015; AIRC-MFAG-11831.

Published
2019

45. Nipple and areola lesions: review of dermoscopy and reflectance confocal microscopy features.

Author

Cinotti E, Galluccio D, Tognetti L, Habougit C, Manganoni AM, Venturini M, Perrot JL, and Rubegni P

Subjects
Carcinoma, Basal Cell diagnostic imaging, Carcinoma, Squamous Cell diagnostic imaging, Diagnosis, Differential, Eczema diagnostic imaging, Humans, Microscopy, Confocal, Breast Neoplasms diagnostic imaging, Dermoscopy, Melanoma diagnostic imaging, Nipples diagnostic imaging, Paget's Disease, Mammary diagnostic imaging, Pigmentation Disorders diagnostic imaging, Skin Neoplasms diagnostic imaging
Abstract

The differential diagnosis of nipple and areola complex (NAC) lesions encompasses a large spectrum of conditions from benign tumours to inflammatory diseases that could be challenging to recognize on clinical ground. While melanoma (MM) of the NAC is exceedingly rare, benign lesions are more frequent but could be difficult to distinguish from MM. Besides MM, other malignant tumours can affect this area and in particular Paget's disease (PD). For clinically doubtful lesions, biopsy is required, with possible functional and aesthetic consequences in this sensitive area. Dermoscopy and reflectance confocal microscopy (RCM) are widely used techniques for the diagnosis of many skin lesions, but their use for NAC lesions is not well established. The objective of this study was to evaluate current literature on these imaging techniques for NAC lesions. We searched in Medline, PubMed and Cochrane database all studies up to November 2018 dealing with dermoscopy, RCM and this special site. We found that the most described malignant tumour was PD and that only two primary MMs of the NAC have been reported with these imaging techniques. Although there are few data on diagnostic accuracy of non-invasive imaging techniques for NAC lesions, it seems that dermoscopy and RCM can add relevant information to be integrated with clinical examination for the diagnosis of NAC lesions and in particular for the differential diagnosis of PD and eczema., (© 2019 European Academy of Dermatology and Venereology.)

Published
2019
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47. Patient perspectives of early detection of melanoma: the experience at the Brescia Melanoma Centre, Italy.

Author

Manganoni AM, Pavoni L, and Calzavara-Pinton P

Subjects
Adult, Aged, Aged, 80 and over, Early Detection of Cancer, Female, Humans, Italy epidemiology, Male, Melanoma epidemiology, Melanoma pathology, Middle Aged, Nevus epidemiology, Nevus pathology, Pilot Projects, Skin Neoplasms epidemiology, Skin Neoplasms pathology, Young Adult, Melanoma diagnosis, Nevus diagnosis, Self-Examination, Skin Neoplasms diagnosis
Abstract

Aim: Skin self-examination is usually recommended for early melanoma diagnosis. Given the current lack of a standardized Skin Self-Examination method, we raised the issue about the suitable approach to explain to patients what can be considered a suspicious lesion. Hereinafter, we report the results of a pilot-study carried out at the Melanoma Centre, University Hospital Spedali Civili Brescia, Italy., Methods: A consecutive sample of 200 melanoma patients entered into the Melanoma Prevention Project. A detailed survey revealed who had the first suspicion of the melanoma lesion. When melanoma was Self- or Relative-detected, we investigated the signs/symptoms that had alerted patients with reference to the ABCDE rule. The study included also socio-demographic variables, family history of melanoma, skin type, number and type of nevi, and melanoma features., Results: Eighty-seven melanoma had been Self-Detected and 44 Relative-Detected. Patients report most commonly signs/symptoms such as dark colour (58%) and changing in size (47%). Seventy-nine percent of these patients have less than ten nevi and 92% have small and regular moles., Conclusion: Sometimes the signs of melanoma seem to be easy to identify. Our patients say that they recognized melanoma on the base of the Colour and the Change in size. Therefore, we propose the short "CC" acronym that could facilitate the melanoma self-diagnosis. The aim is to give a short and effective message that leads patients to have the doubt of a suspicious lesion of melanoma so that they seek medical attention.

Published
2015

48. Differences in clinicopathological features and distribution of risk factors in Italian melanoma patients.

Author

Fava P, Astrua C, Chiarugi A, Crocetti E, Pimpinelli N, Fargnoli MC, Maurichi A, Rubegni P, Manganoni AM, Bottoni U, Catricalà C, Cavicchini S, Santinami M, Alaibac M, Annetta A, Borghi A, Calzavara Pinton P, Capizzi R, Clerico R, Colombo E, Corradin MT, De Simone P, Fantini F, Ferreli C, Filosa G, Girgenti V, Giulioni E, Guarneri C, Lamberti A, Lisi P, Nardini P, Papini M, Peris K, Pizzichetta MA, Salvini C, Savoia P, Strippoli D, Tolomio E, Tomassini MA, Vena GA, Zichichi L, Patrizi A, Argenziano G, Simonacci M, and Quaglino P

Subjects
Humans, Italy epidemiology, Middle Aged, Risk Factors, Melanoma epidemiology, Melanoma pathology, Skin Neoplasms epidemiology, Skin Neoplasms pathology
Abstract

Background: No studies are available in the literature on the distribution of different melanoma features and risk factors in the Italian geographical areas., Objective: To identify the differences in clinical-pathological features of melanoma, the distribution of risk factors and sun exposure in various Italian macro-areas., Methods: Multicentric-observational study involving 1,472 melanoma cases (713 north, 345 centre, 414 south) from 26 referral centres belonging to the Italian Multidisciplinary Group for Melanoma., Results: Melanoma patients in northern regions are younger, with thinner melanoma, multiple primaries, lower-intermediate phototype and higher counts of naevi with respect to southern patients; detection of a primary was mostly connected with a physician examination, while relatives were more involved in the south. Northern patients reported a more frequent use of sunbeds and occurrence of sunburns before melanoma despite sunscreen use and a lower sun exposure during the central hours of the day., Conclusions: The understanding of differences in risk factors distribution could represent the basis for tailored prevention programmes.

Published
2015
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49. Follow-up of cutaneous melanoma patients: a proposal for standardization.

Author

Moscarella E, Ricci C, Borgognoni L, Bottoni U, Catricalà C, Dika E, Fanti PA, Landi C, Manganoni AM, Pellacani G, Peris K, Pimpinelli N, Quaglino P, Richetta A, Simonetti V, Stanganelli I, Testori A, Zalaudek I, and Argenziano G

Subjects
Follow-Up Studies, Humans, Practice Guidelines as Topic, Reference Standards, Melanoma diagnosis, Skin Neoplasms diagnosis
Published
2014

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