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1. Upper endoscopy in elderly patients: a multicentre, cross-sectional study

Author

Zullo, Angelo, De Francesco, Vincenzo, Amato, Arnaldo, Bergna, Irene, Bendia, Emanuele, Giorgini, Giorgia, Buscarini, Elisabetta, Manfredi, Guido, Cadoni, Sergio, Cannizzaro, Renato, Realdon, Stefano, Ciuffi, Mario, Ignomirelli, Orazio, Da Massa Carrara, Paola, Finucci, Giovanni, Di Somma, Antonietta, Frandina, Chiara, Loria, Mariafrancesca, Galeazzi, Francesca, Ferrara, Francesco, Gemme, Carlo, Bertetti, Noemi Sara, Gentili, Federica, Lotito, Antonio, Germanà, Bastianello, Russo, Nunzia, Grande, Giuseppe, Conigliaro, Rita, Cravero, Federico, Venezia, Giovanna, Marmo, Riccardo, Senneca, Piera, Milano, Angelo, Efthymakis, Konstantinos, Monica, Fabio, Montalto, Paolo, Lombardi, Mario, Morelli, Olivia, Castellani, Danilo, Nigro, Daniela, Festa, Roberto, Peralta, Sergio, Grasso, Maria, Privitera, Antonello, Di Stefano, Maria Emanuela, Scaccianoce, Giuseppe, Loiacono, Mariangela, Segato, Sergio, Balzarini, Marco, Satta, Paolo Usai, Lai, Mariantonia, Fortunato, Francesca, and Manta, Raffaele

Published
2024
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2. Monitoring Unmanned Aircraft: Specification, Integration, and Lessons-learned

Author

Baumeister, Jan, Finkbeiner, Bernd, Kohn, Florian, Löhr, Florian, Manfredi, Guido, Schirmer, Sebastian, and Torens, Christoph

Subjects
Computer Science - Software Engineering, Computer Science - Logic in Computer Science, F.3.1, J.2
Abstract

This paper reports on the integration of runtime monitoring into fully-electric aircraft designed by Volocopter, a German aircraft manufacturer of electric multi-rotor helicopters. The runtime monitor recognizes hazardous situations and system faults. Since the correct operation of the monitor is critical for the safety of the aircraft, the development of the monitor must follow strict aeronautical standards. This includes the integration of the monitor into different development environments, such as log-file analysis, hardware/software-in-the-loop testing, and test flights. We have used the stream-based monitoring framework RTLola to generate monitors for a range of requirements. In this paper, we present representative monitoring specifications and our lessons learned from integrating the generated monitors. Our main finding is that the specification and the integration need to be decoupled, because the specification remains stable throughout the development process, whereas the different development stages require a separate integration of the monitor into each environment. We achieve this decoupling with a novel abstraction layer in the monitoring framework that adapts the monitor to each environment without affecting the core component generated from the specification. The decoupling of the integration has also allowed us to react quickly to the frequent changes in the hardware and software environment of the monitor due to the fast-paced development of the aircraft in a startup company.

Published
2024

3. Correction to: Upper endoscopy in elderly patients: A multicentre, cross‑sectional study

Author

Zullo, Angelo, De Francesco, Vincenzo, Amato, Arnaldo, Bergna, Irene, Bendia, Emanuele, Giorgini, Giorgia, Buscarini, Elisabetta, Manfredi, Guido, Cadoni, Sergio, Cannizzaro, Renato, Realdon, Stefano, Ciuffi, Mario, Ignomirelli, Orazio, Da Massa Carrara, Paola, Finucci, Giovanni, Di Somma, Antonietta, Frandina, Chiara, Loria, Mariafrancesca, Galeazzi, Francesca, Ferrara, Francesco, Gemme, Carlo, Bertetti, Noemi Sara, Gentili, Federica, Lotito, Antonio, Germanà, Bastianello, Russo, Nunzia, Grande, Giuseppe, Conigliaro, Rita, Cravero, Federico, Venezia, Giovanna, Marmo, Riccardo, Senneca, Piera, Milano, Angelo, Efthymakis, Konstantinos, Monica, Fabio, Montalto, Paolo, Lombardi, Mario, Morelli, Olivia, Castellani, Danilo, Nigro, Daniela, Festa, Roberto, Peralta, Sergio, Grasso, Maria, Privitera, Antonello, Di Stefano, Maria Emanuela, Scaccianoce, Giuseppe, Loiacono, Mariangela, Segato, Sergio, Balzarini, Marco, Satta, Paolo Usai, Lai, Mariantonia, Fortunato, Francesca, and Manta, Raffaele

Published
2024
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6. Real-time determination of gastric juice pH with EndoFaster® for atrophic gastritis assessment

Author

Zullo, Angelo, Germanà, Bastianello, Galliani, Ermenegildo, Iori, Andrea, de Pretis, Giovanni, Manfredi, Guido, Buscarini, Elisabetta, Ciuffi, Mario, Ignomirelli, Orazio, Farinati, Fabio, Savarino, Edoardo, Pallini, Paolo, Milan, Luisa, Conigliaro, Rita, Grande, Giuseppe, Cannizzaro, Renato, Maiero, Stefania, Pisani, Antonio, Marangi, Stefania, Manta, Raffaele, Morelli, Olivia, Peralta, Sergio, La Mantia, Alessia, Buonocore, Matteo Rossano, Khalaf, Kareem, Hassan, Cesare, and Monica, Fabio

Published
2022
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8. European Reference Network for Rare Vascular Diseases (VASCERN): When and how to use intravenous bevacizumab in Hereditary Haemorrhagic Telangiectasia (HHT)?

Author

Crocione, Claudia, Blom, Ria, Botella, Luisa Maria, Brocca, Fernando, Coxall, Caroline, Druckman, Karen T., Erasme, Didier, Federici, Paolo, Grabowski, Christina, Lundgren, Mildred, Søderman, Tone, Woods, Dara, Dupuis-Girod, Sophie, Shovlin, Claire L., Kjeldsen, Anette D., Mager, Hans-Jurgen, Sabba, Carlo, Droege, Freya, Fargeton, Anne-Emmanuelle, Fialla, Annette D., Gandolfi, Silvia, Hermann, Ruben, Lenato, Gennaro M., Manfredi, Guido, Post, Marco C., Rennie, Catherine, Suppressa, Patrizia, Sure, Ulrich, and Buscarini, Elisabetta

Published
2022
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9. Hereditary Hemorrhagic Telangiectasia: On the Brink of a New Treatment Era?

Author

Cerrone, Antonio, Buscarini, Elisabetta, Berté, Roberto, Alicante, Saverio, Bertolazzi, Stefania, Moreschi, Olivia, Griffanti, Paola, and Manfredi, Guido

Subjects
HEREDITARY hemorrhagic telangiectasia, ARTERIOVENOUS malformation, TELANGIECTASIA, BLOOD vessels, CELLULAR signal transduction
Abstract

Hereditary hemorrhagic telangiectasia (HHT) is an inherited vascular disorder with highly variable penetrance, affecting up to 1 in 5,000 individuals. It is characterized by the presence of abnormal blood vessels that can lead to excessive bleeding—most frequently recurrent nosebleeds (epistaxis), skin and mucosal telangiectasias (small, dilated blood vessels), as well as arteriovenous malformations (AVMs) that can form in various organs, particularly the lungs, liver, and brain. HHT is caused by loss-of-function mutations in the BMP9–10/ENG/ALK1/SMAD4 signaling pathway, an important mediator of vascular quiescence. HHT possesses significant challenges for affected individuals, as the complications can range from mild to life-threatening events, depending on the severity and location of the vascular abnormalities. Despite this bleeding disorder being not uncommon, nowadays no specific treatment is as yet available for HHT and most current therapies include repurposed drugs. The aim of this review was to show therapeutic advances on the basis of recent promising clinical trials for HHT. [ABSTRACT FROM AUTHOR]

Published
2025
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14. Endoscopic Findings in Patients Infected With 2019 Novel Coronavirus in Lombardy, Italy

Author

Massironi, Sara, Viganò, Chiara, Dioscoridi, Lorenzo, Filippi, Elisabetta, Pagliarulo, Michela, Manfredi, Guido, Conti, Clara Benedetta, Signorelli, Clementina, Redaelli, Alessandro Ettore, Bonato, Giulia, Iiritano, Elena, Frego, Roberto, Zucchini, Nicola, Ungari, Marco, Pedaci, Marianna, Bono, Francesca, Di Bella, Camillo, Buscarini, Elisabetta, Mutignani, Massimiliano, Penagini, Roberto, Dinelli, Marco Emilio, and Invernizzi, Pietro

Published
2020
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15. Linked-color imaging versus white-light colonoscopy in an organized colorectal cancer screening program

Author

Paggi, Silvia, Radaelli, Franco, Senore, Carlo, Maselli, Roberta, Amato, Arnaldo, Andrisani, Gianluca, Di Matteo, Francesco, Cecinato, Paolo, Grillo, Simone, Sereni, Giuliana, Sassatelli, Romano, Manfredi, Guido, Alicante, Saverio, Buscarini, Elisabetta, Canova, Daniele, Milan, Luisa, Pallini, Paolo, Iwatate, Mineo, Rondonotti, Emanuele, Repici, Alessandro, and Hassan, Cesare

Published
2020
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16. Complications and early mortality in percutaneous endoscopic gastrostomy placement in lombardy: A multicenter prospective cohort study

Author

Anderloni, Andrea, Di Leo, Milena, Barzaghi, Franco, Semeraro, Rossella, Meucci, Gianmichele, Marino, Roberta, Amato, Loretta, Frigerio, Mauro, Saladino, Valeria, Toldi, Anna, Manfredi, Guido, Redaelli, Alessandro, Feliziani, Marcella, De Roberto, Giuseppe, Boni, Francesca, Scacchi, Gianlorenzo, Mosca, Davide, Devani, Massimo, Arena, Monica, Massidda, Marco, Zanoni, Paolo, Ciscato, Camilla, Casini, Valentina, Beretta, Paolo, Forti, Edoardo, Salerno, Raffaele, Caramia, Vitantonio, Bianchetti, Mario, Tomba, Carolina, Evangelista, Andrea, Repici, Alessandro, Soncini, Marco, Maconi, Giovanni, Manes, Gianpiero, and Gullotta, Renzo

Published
2019
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17. Prospective evaluation of ERCP performance in an Italian regional database study

Author

Mariani, Alberto, Segato, Simone, Anderloni, Andrea, Cengia, Gianpaolo, Parravicini, Marco, Staiano, Teresa, Tontini, Gian Eugenio, Lochis, Davide, Cantù, Paolo, Manfredi, Guido, Amato, Arnaldo, Bargiggia, Stefano, Bernasconi, Giordano, Lella, Fausto, Berni Canani, Marcella, Beretta, Paolo, Ferraris, Luca, Signorelli, Sergio, Pantaleo, Giuseppe, Manes, Gianpiero, Testoni, Pier Alberto, Prada, Alberto, Iiritano, Elena, Lesinigo, Enrico, Mezzi, Gianni Santo, and de Nucci, Germana

Published
2019
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18. Diagnosis of chronic anaemia in gastrointestinal disorders: A guideline by the Italian Association of Hospital Gastroenterologists and Endoscopists (AIGO) and the Italian Society of Paediatric Gastroenterology Hepatology and Nutrition (SIGENP)

Author

Elli, Luca, Norsa, Lorenzo, Zullo, Angelo, Carroccio, Antonio, Girelli, Carlo, Oliva, Salvatore, Romano, Claudio, Leandro, Gioacchino, Bellini, Massimo, Marmo, Riccardo, Soncini, Marco, Monica, Fabio, De Francesco, Vincenzo, Paulon, Emma, Cappellini, Maria Domenica, Motta, Irene, Ferretti, Francesca, Orlando, Stefania, Mansueto, Pasquale, Buscarini, Elisabetta, Manfredi, Guido, Agostoni, Carlo, Tomba, Carolina, and Cannizzaro, Renato

Published
2019
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19. Upper Gastrointestinal Endoscopy Quality in Italy: A Nationwide Study

Author

Zullo, Angelo, primary, De Francesco, Vincenzo, primary, Amato, Arnaldo, primary, Bergna, Irene, primary, Bendia, Emanuele, primary, Giorgini, Giorgia, primary, Buscarini, Elisabetta, primary, Manfredi, Guido, primary, Cadoni, Sergio, primary, Cannizzaro, Renato, primary, Realdon, Stefano, primary, Ciuffi, Mario, primary, Ignomirelli, Orazio, primary, Da Massa Carrara, Paola, primary, Finucci, Giovanni, primary, Di Somma, Antonietta, primary, Frandina, Chiara, primary, Loria, Mariafrancesca, primary, Galeazzi, Francesca, primary, Ferrara, Francesco, primary, Gemme, Carlo, primary, Bertetti, Noemi Sara, primary, Gentili, Federica, primary, Lotito, Antonio, primary, Germanà, Bastianello, primary, Russo, Nunzia, primary, Grande, Giuseppe, primary, Conigliaro, Rita, primary, Cravero, Federico, primary, Venezia, Giovanna, primary, Marmo, Riccardo, primary, Senneca, Piera, primary, Milano, Angelo, primary, Efthymakis, Konstantinos, primary, Monica, Fabio, primary, Montalto, Paolo, primary, Lombardi, Mario, primary, Morelli, Olivia, primary, Castellani, Danilo, primary, Nigro, Daniela, primary, Festa, Roberto, primary, Peralta, Sergio, primary, Grasso, Maria, primary, Privitera, Antonello, primary, Distefano, Maria Emanuela, primary, Scaccianoce, Giuseppe, primary, Loiacono, Mariangela, primary, Segato, Sergio, primary, Balzarini, Marco, primary, Usai Satta, Paolo, primary, Lai, Mariantonia, primary, and Manta, Raffaele, primary

Published
2023
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27. European Reference Network for Rare Vascular Diseases (VASCERN) position statement on cerebral screening in adults and children with hereditary haemorrhagic telangiectasia (HHT)

Author

Eker, Omer F., Boccardi, Edoardo, Sure, Ulrich, Patel, Maneesh C., Alicante, Saverio, Alsafi, Ali, Coote, Nicola, Droege, Freya, Dupuis, Olivier, Fialla, Annette Dam, Jones, Bryony, Kariholu, Ujwal, Kjeldsen, Anette D., Lefroy, David, Lenato, Gennaro M., Mager, Hans Jurgen, Manfredi, Guido, Nielsen, Troels H., Pagella, Fabio, Post, Marco C., Rennie, Catherine, Sabbà, Carlo, Suppressa, Patrizia, Toerring, Pernille M., Ugolini, Sara, Buscarini, Elisabetta, Dupuis-Girod, Sophie, and Shovlin, Claire L.

Published
2020
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29. Visual Localisation from Structureless Rigid Models

Author

Manfredi, Guido, Devy, Michel, Sidobre, Daniel, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Battiato, Sebastiano, editor, Blanc-Talon, Jacques, editor, Gallo, Giovanni, editor, Philips, Wilfried, editor, Popescu, Dan, editor, and Scheunders, Paul, editor

Published
2015
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30. Textured Object Recognition: Balancing Model Robustness and Complexity

Author

Manfredi, Guido, Devy, Michel, Sidobre, Daniel, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Azzopardi, George, editor, and Petkov, Nicolai, editor

Published
2015
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33. Content Makes the Difference in Compression Standard Quality Assessment

Author

Manfredi, Guido, Ziou, Djemel, Auclair-Fortier, Marie-Flavie, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Blanc-Talon, Jacques, editor, Kleihorst, Richard, editor, Philips, Wilfried, editor, Popescu, Dan, editor, and Scheunders, Paul, editor

Published
2011
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34. Impact of improved upper endoscopy quality on detection of gastric precancerous lesions

Author

Manfredi, Guido, primary, Pedaci, Marianna, additional, Iiritano, Elena, additional, Alicante, Saverio, additional, Romeo, Samanta, additional, Bertè, Roberto, additional, Londoni, Claudio, additional, Menozzi, Fernanda, additional, Brambilla, Gianfranco, additional, Pezzilli, Raffaele, additional, Zullo, Angelo, additional, and Buscarini, Elisabetta, additional

Published
2023
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35. Italian consensus guidelines for the diagnostic work-up and follow-up of cystic pancreatic neoplasms

Author

Albarello, Luca, Camellini, Lorenzo, Cantù, Paolo, Conigliaro, Rita, Costamagna, Guido, Del Favero, Giuseppe, Del Vecchio Blanco, Giovanna, Di Sebastiano, Pierluigi, Fabbri, Carlo, Federici, Paolo, Funel, Niccola, Galli, Andrea, Gabbrielli, Armando, Graziani, Rossella, Guadagnini, Tiziana, Laghi, Andrea, Macarri, Giampiero, Magnolfi, Fabrizio, Marzioni, Marco, Monica, Fabio, Muscatiello, Nicola, Mutignani, Massimiliano, Pisani, Antonio, Scarano, Enrico, Serra, Carla, Spada, Marco, Visconti, Marco, Zambelli, Alessandro, Buscarini, Elisabetta, Pezzilli, Raffaele, Cannizzaro, Renato, Angelis, Claudio De, Gion, Massimo, Morana, Giovanni, Zamboni, Giuseppe, Arcidiacono, Paolo, Balzano, Gianpaolo, Barresi, Luca, Basso, Daniela, Bocus, Paolo, Calculli, Lucia, Capurso, Gabriele, Canzonieri, Vincenzo, Casadei, Riccardo, Crippa, Stefano, D’Onofrio, Mirko, Frulloni, Luca, Fusaroli, Pietro, Manfredi, Guido, Pacchioni, Donatella, Pasquali, Claudio, Rocca, Rodolfo, Ventrucci, Maurizio, Venturini, Silvia, Villanacci, Vincenzo, Zerbi, Alessandro, and Falconi, Massimo

Published
2014
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36. Prevalence of Endoscopic and Histological Lesions at Upper Endoscopy: A Cross-Sectional, Multicentre Study in Clinical Practice

Author

De Francesco, Vincenzo, Zullo, Angelo, Amato, Arnaldo, Bergna, Irene, Bendia, Emanuele, Giorgini, Giorgia, Buscarini, Elisabetta, Manfredi, Guido, Cadoni, Sergio, Cannizzaro, Renato, Realdon, Stefano, Ciuffi, Mario, Ignomirelli, Orazio, Da Massa Carrara, Paola, Finucci, Giovanni, Di Somma, Antonietta, Frandina, Chiara, Loria, Mariafrancesca, Galeazzi, Francesca, Ferrara, Francesco, Gemme, Carlo, Bertetti, Noemi Sara, Gentili, Federica, Lotito, Antonio, Germanà, Bastianello, Russo, Nunzia, Grande, Giuseppe, Conigliaro, Rita, Cravero, Federico, Venezia, Giovanna, Marmo, Riccardo, Senneca, Piera, Milano, Angelo, Efthymakis, Konstantinos, Monica, Fabio, Montalto, Paolo, Lombardi, Mario, Morelli, Olivia, Castellani, Danilo, Nigro, Daniela, Festa, Roberto, Peralta, Sergio, Grasso, Maria, Privitera, Antonino Carlo, Di Stefano, Maria Emanuela, Scaccianoce, Giuseppe, Loiacono, Mariangela, Segato, Sergio, Balzarini, Marco, Usai Satta, Paolo, Lai, Mariantonia, and Manta, Raffaele

Abstract

Background/Aim:Prevalence of gastroduodenal endoscopic and histological lesions may modify over time due to different factors. We assessed both macroscopic and histological lesions currently detected at upper endoscopy performed in routine practice. Patients and Methods:Clinical, endoscopic, and histological data of consecutive adult patients referred for upper endoscopy in the 28 participating centres were analysed. Only patients who underwent the first endoscopic examination were considered. Prevalence of erosive/ulcerative lesions, cancers and extensive precancerous lesions in the stomach, and Helicobacter pyloriinfection was computed. Results:A total of 1,431 patients underwent endoscopy for gastro-oesophageal reflux symptoms (31.5%), dyspepsia (29.4%), or alarm symptoms (18.5%). Erosive oesophagitis or Barrett’s oesophagus was detected in 210 (14.7%) cases, peptic ulcer in 49 (3.4%), and a neoplastic lesion in 17 (1.2%). H. pyloriwas present in 201 (22.6%) cases, and extensive precancerous lesions on gastric mucosa in 46 (5.6%) patients. Gastric lesions were more prevalent in patients aged ≥50 years (26% vs. 18%; p= 0.001), and peptic ulcers were more frequently detected in patients with H. pylori(9.4% vs. 2.3%; p= 0.001) and in males (5.8% vs. 1.6%; p= 0.001), while neoplastic lesions in patients with alarm symptoms (3.8% vs. 0.6%; p= 0.001). Conclusions:The overall endoscopic lesions were more prevalent in patients aged ≥50 years, peptic ulcer and erosions were more frequent in H. pylori-infected patients, and extensive gastric precancerous lesions were present in less than 6% of cases.

Published
2024
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37. European Reference Network for Rare Vascular Diseases (VASCERN): When and how to use intravenous bevacizumab in Hereditary Haemorrhagic Telangiectasia (HHT)?

Author

Dupuis-Girod, Sophie, primary, Shovlin, Claire L., additional, Kjeldsen, Anette D., additional, Mager, Hans-Jurgen, additional, Sabba, Carlo, additional, Droege, Freya, additional, Fargeton, Anne-Emmanuelle, additional, Fialla, Annette D., additional, Gandolfi, Silvia, additional, Hermann, Ruben, additional, Lenato, Gennaro M., additional, Manfredi, Guido, additional, Post, Marco C., additional, Rennie, Catherine, additional, Suppressa, Patrizia, additional, Sure, Ulrich, additional, Buscarini, Elisabetta, additional, Crocione, Claudia, additional, Blom, Ria, additional, Botella, Luisa Maria, additional, Brocca, Fernando, additional, Coxall, Caroline, additional, Druckman, Karen T., additional, Erasme, Didier, additional, Federici, Paolo, additional, Grabowski, Christina, additional, Lundgren, Mildred, additional, Søderman, Tone, additional, and Woods, Dara, additional

Published
2022
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38. Real-time gastric juice analysis with EndoFaster for H. pylori diagnosis: a large, multicentre study

Author

Zullo, Angelo, primary, Germanà, Bastianello, additional, Galliani, Ermenegildo, additional, Iori, Andrea, additional, de Pretis, Giovanni, additional, Manfredi, Guido, additional, Buscarini, Elisabetta, additional, Ciuffi, Mario, additional, Ignomirelli, Orazio, additional, Farinati, Fabio, additional, Savarino, Edoardo, additional, Pallini, Paolo, additional, Milan, Luisa, additional, Conigliaro, Rita, additional, Grande, Giuseppe, additional, Cannizzaro, Renato, additional, Maiero, Stefania, additional, Pisani, Antonio, additional, Marangi, Stefania, additional, Manta, Raffaele, additional, Morelli, Olivia, additional, Peralta, Sergio, additional, Alessia, La Mantia, additional, Rossano Buonocore, Matteo, additional, and Monica, Fabio, additional

Published
2022
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42. Wet-suction versus slow-pull technique for endoscopic ultrasound-guided fine-needle biopsy: a multicenter, randomized, crossover trial

Author

Crinò, Stefano Francesco, additional, Conti Bellocchi, Maria Cristina, additional, Di Mitri, Roberto, additional, Inzani, Frediano, additional, Rimbaș, Mihai, additional, Lisotti, Andrea, additional, Manfredi, Guido, additional, Teoh, Anthony Y. B., additional, Mangiavillano, Benedetto, additional, Sendino, Oriol, additional, Bernardoni, Laura, additional, Manfrin, Erminia, additional, Scimeca, Daniela, additional, Unti, Elettra, additional, Carlino, Angela, additional, Voiosu, Theodor, additional, Mateescu, R. Bogdan, additional, Fusaroli, Pietro, additional, Lega, Stefania, additional, Buscarini, Elisabetta, additional, Pergola, Lorena, additional, Chan, Shannon M., additional, Lamonaca, Laura, additional, Ginès, Àngels, additional, Fernández-Esparrach, Gloria, additional, Facciorusso, Antonio, additional, and Larghi, Alberto, additional

Published
2022
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43. EUS-FNB WITH WET-SUCTION VERSUS SLOW-PULL FOR DIAGNOSIS OF SOLID LESIONS: INTERIM ANALYSIS OF AN INTERNATIONAL RANDOMIZED, CROSS-OVER TRIAL

Author

Crinò, Stefano Francesco, primary, Conti Bellocchi, Maria Cristina, additional, Di Mitri, Roberto, additional, Inzani, Frediano, additional, Rimbas, Mihai, additional, Lisotti, Andrea, additional, Manfredi, Guido, additional, Teoh, Anthony Y., additional, Mangiavillano, Benedetto, additional, Sendino, Oriol, additional, Bernardoni, Laura, additional, Manfrin, Erminia, additional, Scimeca, Daniela, additional, Unti, Elettra, additional, Carlino, Angela, additional, Voiosu, Theodor, additional, Popp, Cristiana, additional, Fusaroli, Pietro, additional, Lega, Stefania, additional, Buscarini, Elisabetta, additional, Pergola, Lorena, additional, Chan, Shannon M., additional, Lamonaca, Laura, additional, Ginès, Angel, additional, Fernández-Esparrach, Gloria, additional, Facciorusso, Antonio, additional, and Larghi, Alberto, additional

Published
2022
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45. Hereditary hemorrhagic telangiectasia: First demonstration of a founder effect in Italy; the ACVRL1 c.289_294del variant originated in the country of Bergamo 200 years ago

Author

Sbalchiero, Anna, primary, Abu Hweij, Yasmin, additional, Mazza, Tommaso, additional, Buscarini, Elisabetta, additional, Scotti, Claudia, additional, Pagella, Fabio, additional, Manfredi, Guido, additional, Matti, Elina, additional, Spinozzi, Giuseppe, additional, and Olivieri, Carla, additional

Published
2022
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46. Wet-suction versus slow-pull technique for endoscopic ultrasound-guided fine-needle biopsy: a multicenter, randomized, crossover trial.

Author

Crinò, Stefano Francesco, Conti Bellocchi, Maria Cristina, Di Mitri, Roberto, Inzani, Frediano, Rimbaș, Mihai, Lisotti, Andrea, Manfredi, Guido, Teoh, Anthony Y. B., Mangiavillano, Benedetto, Sendino, Oriol, Bernardoni, Laura, Manfrin, Erminia, Scimeca, Daniela, Unti, Elettra, Carlino, Angela, Voiosu, Theodor, Mateescu, R. Bogdan, Fusaroli, Pietro, Lega, Stefania, and Buscarini, Elisabetta

Subjects
ENDOSCOPIC ultrasonography, CROSSOVER trials, BIOPSY, BLOOD sampling
Abstract

Background It is unknown whether there is an advantage to using the wet-suction or slow-pull technique during endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) with new-generation needles. We aimed to compare the performance of each technique in EUS-FNB. Methods This was a multicenter, randomized, single-blind, crossover trial including patients with solid lesions of ≥ 1 cm. Four needle passes with 22 G fork-tip or Franseen-type needles were performed, alternating the wet-suction and slow-pull techniques in a randomized order. The primary outcome was the histological yield (samples containing an intact piece of tissue of at least 550 μm). Secondary end points were sample quality (tissue integrity and blood contamination), diagnostic accuracy, and adequate tumor fraction. Results Overall, 210 patients with 146 pancreatic and 64 nonpancreatic lesions were analyzed. A tissue core was retrieved in 150 (71.4 %) and 129 (61.4 %) cases using the wet-suction and the slow-pull techniques, respectively (P = 0.03). The mean tissue integrity score was higher using wet suction (P = 0.02), as was the blood contamination of samples (P < 0.001). In the two subgroups of pancreatic and nonpancreatic lesions, tissue core rate and tissue integrity score were not statistically different using the two techniques, but blood contamination was higher with wet suction. Diagnostic accuracy and tumor fraction did not differ between the two techniques. Conclusion Overall, the wet-suction technique in EUS-FNB resulted in a higher tissue core procurement rate compared with the slow-pull method. Diagnostic accuracy and the rate of samples with adequate tumor fraction were similar between the two techniques. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Natural History and Outcome of Hepatic Vascular Malformations in a Large Cohort of Patients with Hereditary Hemorrhagic Teleangiectasia

Author

Buscarini, Elisabetta, Leandro, Gioacchino, Conte, Dario, Danesino, Cesare, Daina, Erica, Manfredi, Guido, Lupinacci, Guido, Brambilla, Gianfranco, Menozzi, Fernanda, De Grazia, Federico, Gazzaniga, Pietro, Inama, Giuseppe, Bonardi, Roberto, Blotta, Pasquale, Forner, PierAngelo, Olivieri, Carla, Perna, Annalisa, Grosso, Maurizio, Pongiglione, Giacomo, Boccardi, Edoardo, Pagella, Fabio, Rossi, Giorgio, and Zambelli, Alessandro

Published
2011
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