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3. The Evolving Role of Genomic Testing in Early Breast Cancer: Implications for Diagnosis, Prognosis, and Therapy

Author

Venetis, Konstantinos, primary, Pescia, Carlo, additional, Cursano, Giulia, additional, Frascarelli, Chiara, additional, Mane, Eltjona, additional, De Camilli, Elisa, additional, Munzone, Elisabetta, additional, Dellapasqua, Silvia, additional, Criscitiello, Carmen, additional, Curigliano, Giuseppe, additional, Guerini Rocco, Elena, additional, and Fusco, Nicola, additional

Published
2024
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4. Early Breast Cancer Risk Assessment: Integrating Histopathology with Artificial Intelligence

Author

Ivanova, Mariia, primary, Pescia, Carlo, additional, Trapani, Dario, additional, Venetis, Konstantinos, additional, Frascarelli, Chiara, additional, Mane, Eltjona, additional, Cursano, Giulia, additional, Sajjadi, Elham, additional, Scatena, Cristian, additional, Cerbelli, Bruna, additional, d’Amati, Giulia, additional, Porta, Francesca Maria, additional, Guerini-Rocco, Elena, additional, Criscitiello, Carmen, additional, Curigliano, Giuseppe, additional, and Fusco, Nicola, additional

Published
2024
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5. PIK3CA testing in hormone receptor-positive/HER2-negative metastatic breast cancer: real-world data from Italian molecular pathology laboratories

Author

Pepe, Francesco, primary, Venetis, Konstantinos, additional, Cursano, Giulia, additional, Frascarelli, Chiara, additional, Pisapia, Pasquale, additional, Vacirca, Davide, additional, Scimone, Claudia, additional, Rappa, Alessandra, additional, Russo, Gianluca, additional, Mane, Eltjona, additional, Pagni, Fabio, additional, Castellano, Isabella, additional, Troncone, Giancarlo, additional, Angelis, Carmine De, additional, Curigliano, Giuseppe, additional, Guerini-Rocco, Elena, additional, Malapelle, Umberto, additional, and Fusco, Nicola, additional

Published
2024
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6. Multimodal histopathologic models stratify hormone receptor-positive early breast cancer

Author

Boehm, Kevin Michael, primary, El Nahhas, Omar S. M., additional, Marra, Antonio, additional, Selenica, Pier, additional, Wen, Hannah Y, additional, Weigelt, Britta, additional, Paul, Evan D, additional, Cekan, Pavol, additional, Erber, Ramona, additional, Loeffler, Chiara M. L., additional, Guerini-Rocco, Elena, additional, Fusco, Nicola, additional, Frascarelli, Chiara, additional, Mane, Eltjona, additional, Munzone, Elisabetta, additional, Dellapasqua, Silvia, additional, Zagami, Paola, additional, Curigliano, Giuseppe, additional, Razavi, Pedram, additional, Reis-Filho, Jorge S., additional, Pareja, Fresia, additional, Chandarlapaty, Sarat, additional, Shah, Sohrab P, additional, and Kather, Jakob Nikolas, additional

Published
2024
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7. A novel, RAS-independent role for NF1 in microtubular dynamics and damage repair dictates sensitivity to T-DM1 in HER2-positive breast cancer

Author

Achutti Duso, Bruno, primary, Messuti, Eleonora, additional, Tini, Giulia, additional, Bonetti, Emanuele, additional, Castiglioni, Alessia, additional, Frige, Gianmaria, additional, Ciossani, Giuseppe, additional, Monzani, Silvia, additional, Soriani, Chiara, additional, Khuntsariya, Daria, additional, Roda, Nicolo, additional, Polazzi, Andrea, additional, Ippolito, Marica Rosaria, additional, Gavilan Dorronzoro, Elena, additional, Mane, Eltjona, additional, Farfalla, Alessia, additional, Jemos, Costantino, additional, Guerini Rocco, Elena, additional, Rodighero, Simona, additional, Tosoni, Daniela, additional, Santaguida, Stefano, additional, Braun, Marcus, additional, Lansky, Zdenek, additional, Scietti, Luigi Angelo, additional, Pelicci, Pier Giuseppe, additional, and Mazzarella, Luca, additional

Published
2023
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8. Revolutionizing Cancer Research: The Impact of Artificial Intelligence in Digital Biobanking

Author

Frascarelli, Chiara, primary, Bonizzi, Giuseppina, additional, Musico, Camilla Rosella, additional, Mane, Eltjona, additional, Cassi, Cristina, additional, Guerini Rocco, Elena, additional, Farina, Annarosa, additional, Scarpa, Aldo, additional, Lawlor, Rita, additional, Reggiani Bonetti, Luca, additional, Caramaschi, Stefania, additional, Eccher, Albino, additional, Marletta, Stefano, additional, and Fusco, Nicola, additional

Published
2023
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9. PIK3CAtesting in hormone receptor-positive/HER2-negative metastatic breast cancer: real-world data from Italian molecular pathology laboratories

Author

Pepe, Francesco, Venetis, Konstantinos, Cursano, Giulia, Frascarelli, Chiara, Pisapia, Pasquale, Vacirca, Davide, Scimone, Claudia, Rappa, Alessandra, Russo, Gianluca, Mane, Eltjona, Pagni, Fabio, Castellano, Isabella, Troncone, Giancarlo, Angelis, Carmine De, Curigliano, Giuseppe, Guerini-Rocco, Elena, Malapelle, Umberto, and Fusco, Nicola

Abstract

Introduction:PIK3CAgene mutations occur in approximately 40% of hormone receptor-positive/HER2-negative (HR+/HER2−) metastatic breast cancers (MBCs), electing them to targeted therapy. Testing PIK3CAstatus is complex due to selection of biological specimen and testing method. Materials & methods:This work investigates real-life experience on PIK3CAtesting in HR+/HER2−MBC. Clinical, technical and molecular data on PIK3CAtesting were collected from two referral laboratories. Additionally, the results of a nationwide PIK3CAsurvey involving 116 institutions were assessed. Results:Overall, n = 35 MBCs were PIK3CA-mutated, with mutations mostly occurring in exons 9 (n = 19; 51.4%) and 20 (n = 15; 40.5%). The nationwide survey revealed significant variability across laboratories in terms of sampling methodology, technical assessment and clinical report signing healthcare figures for PIK3CAmolecular testing in diagnostic routine practice. Conclusion:This study provides insights into the real-world routine of PIK3CAtesting in HR+/HER2−MBC and highlights the need for standardization and networking in predictive pathology.

Published
2024
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10. An Indeterminate for Malignancy FNA Report Does Not Increase the Surgical Risk of Incidental Thyroid Carcinoma

Author

Seminati, Davide, primary, Mane, Eltjona, additional, Ceola, Stefano, additional, Casati, Gabriele, additional, Putignano, Pietro, additional, Garancini, Mattia, additional, Gatti, Andrea, additional, Leni, Davide, additional, Pincelli, Angela Ida, additional, Fusco, Nicola, additional, L’Imperio, Vincenzo, additional, and Pagni, Fabio, additional

Published
2022
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