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The work purpose is the complex estimation of endogenous intoxication (change of optical density of plasma and erythrocytes), depressions of tissue hypoxia and functions of protective system, clinical and laboratory stratification of the risks-factors promoting progressing of disease and complication of pneumonia. There was carried cross-section study. The study included 36 patients from 1 to 7 years with an acute respiratory infection. The control group was made up of 19 healthy children. The comparative analysis of results of the specified factors and laboratory research set as the purpose to reveal the predictable negative risk factors. Evaluation of the quantitative findings of risks-factors was carried out in 95 % taking into account the confidence interval (CI). For the acute respiratory infection complicated with pneumonia, was determined strongly marked toxemia, and also high activity of antioxidant systems (SOD and catalase) and lysosomal enzymes (catepsin, RNA) was noted. The prognosis of the authentic risks-factors of acute respiratory disease was defined with following indicators: age of the child - before three years; hereditary background with a respiratory system pathology; the tobacco use in a family; low level of knowledge of parents; incomplete treatment; change of optical density of plasma and erythrocytes; fall (reduction) of redox-potential of the system of energy maintenance. We developed predictable model on probability of expected complications of respiratory system and groups of low, average and high risk were allocated.

Two groups of school children (7-16 years old) were studied. One child was from Lukhuni gorge, where arsenic was mined and processed for many years; 11 children were living far (>50 km) from the territory of arsenic mining. Pediatric monitoring revealed significant increase of general morbidity, particularly acute respiratory diseases. Cytogenetic, immunological and hematological investigations were conducted in 43 children (21 from group 1 and 22 from group 11). Simultaneously, the level of arsenic in blood and urine was defined. At all points the differences were revealed, that affirmed the impact of ecological factors on the organism and adaptative processes in children.

Purpose of the work was to investigate clinical-allergic peculiarities of allergic rhinitis, together with bronchial asthma in school-age children. There were studied random representative group of children, in total 3000 subjects from 6 to 17. According to the results of epidemiological research in school-age children's population, prevalence of allergic rhinitis was 13,2%. In 19,1% of cases, allergic rhinitis was accompanied with bronchial asthma and in 8% of the patients there was indicated bronchial spasm of physical load (verified as clinically, also through the test with physical load), coughing version of asthma was observed in 4,5% of children. Thus, in children with allergic rhinitis, within the structure of clinical versions (by the criteria of severity) of rare bronchial asthma prevailed (69,8%, among which 65% - intermitting form and 4,8% - persisting form), without statistically significant difference between the boys and girls. Combination of inherited predisposition to allergy with the atopic dermatitis, in the in the anamnesis of children with the increased level of general IgE in the blood serum may be considered as early diagnostic predictor of atopic phenotype as for the allergic rhinitis, also for its combination with the bronchial asthma.

The purpose of the work was to establish correlation between detected with the help of micronuclei in exfoliation cells infringements in the genetic disorder of Acute Respiratory Infection (ARI) at children living in Lukhuni gorge. Heavy metals having mutagenous trait can cause variety of diseases and first of all influence on the genetic apparatus, which damage often reflects chromosome change. The study of micronuclei in exfoliation cells is comparatively new, easily reachable and believable informative method. From Lukhuni gorge it is indicated true lifting amount of micronuclei. In a distance this indications where far less. It is investigated 150 children: 50 from Lukhuni gorge (I group) where the maintenance of arsenic is sharply raised in environment and 100 from the regions remote from Lukhuni gorge. Amount average quantity micronuclei in 1000 cells in I group was very high 22,38+/-1,26 in. In the second was 4,36+/-0,50 (t=12,82; p<0,0001). All children, under the anamnesis and the clinical data, have been divided on frequently were ill of Acute Respiratory Infection(in one year > 4-5 times) and seldom were ill of Acute Respiratory Infection (< 4-5 times). ARI most frequently were marked in this region. It is revealed correlation between amount of micronuclei in exfoliation cells and parameters of illness respiratory diseases at children living in territories, polluted with arsenic and his derivatives (R=0,789; p<0,000001).

It was established using the methods of genetic-mathematical analysis that the multifactorial model of heredity with uninterrupted distribution of liability is more adequate to the genetic system defining hereditary predisposition to allergoses.