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Background:During the planning of 3D conformal radiotherapy for head and neck tumors, it is crucial to prioritize the dosage that reaches sensitive organs such as the thyroid gland. This is because there is a significant likelihood of developing thyroid dysfunction after radiotherapy, which can greatly impact the patient's quality of life. So, we aimed to evaluate thyroid gland function in H&N cancer patients after head and neck radiotherapy to correlate the relation between the RT dose and thyroid gland dysfunctions. Methods: This prospective study was conducted in Clinical Oncology and Nuclear Medicine Department in Zagazig University Hospitals on 30 patients with head and neck carcinoma who presented to Clinical Oncology department to receive either definitive or adjuvant conformal three dimensional radiotherapy with or without concurrent chemotherapy. Results: At 6 months of follow up, 73.3% had normal thyroid function while 26.7% had subclinical hypothyroidism and none had overt clinical hypothyroidism. However, at 12 months the rates of normal thyroid function dropped to 50% while subclinical hypothyroidism remained stable at 23.3% and now 26.7% demonstrated progression to clinical hypothyroidism. Conclusions: There is a high risk of radiation-induced thyroid dysfunction, particularly clinical hypothyroidism, in head and neck cancer patients receiving radiotherapy. [ABSTRACT FROM AUTHOR]

Background: When it comes to women with malignant gynecological tumor diagnosis, ovarian cancer (OC) is the most prevalent cause of death. Generally, it ranks as the fifth most common cause of mortality for females. Objectives: The present study aimed to study the epidemiological characteristics and treatment outcomes of OC cases in the Clinical Oncology and Nuclear Medicine Department at Zagazig University Hospitals. Methods: This retrospective cohort study targeted seven years from January 2015 to December 2021 and was conducted on 160 medical files of patients with OC from the Clinical Oncology and Nuclear Medicine Department, Zagazig University hospitals. The data of pathological and epidemiological characters and their outcomes were studied. Results: 66.9% of the studied patients had surgery upfront. The most frequent surgery types were TAH + BSO + Surgical staging (38.3%), TAH+BSO (29.4%), and Fertility-sparing surgery was reported in 7.9% of the cases. Regarding primary chemotherapy (95.6%) of patients had Primary chemotherapy as follows (2.5%) Neoadjuvant treatment only, (45%) Adjuvant only, (23.7%) had neoadjuvant and adjuvant, (4.4%) Definitive, and (20%) Palliative treatment. Regarding Hormonal treatment; (6.9%) of patients had Hormonal treatment as follows (1.9%) Adjuvant, (1.3%) Definitive, and (3.7%) salvage for Recurrence. There was a highly significant decrease in all Survival parameters (Local recurrence Free Survival, Regional recurrence Free Survival, Distant metastasis Free Survival, Disease-Free Survival, Progression Free Survival, and Overall survival) as regards an increase in age, Advanced disease & stage and ECOG PS 3, increase in Stage, and Epithelial tumors (p < 0.01 respectively). The mean survival time (MST) was significantly reduced in the advanced disease group compared to other clinical presentation groups. MST was significantly reduced in the ECOG-3 group compared to other ECOG PS groups. MST was significantly reduced in the distant metastasis group compared to other extension of disease groups. MST was significantly reduced in the stage IV group compared to other histopathology stage groups. MST was significantly reduced in the serious adverse effects group compared to the no serious adverse effects group. Conclusion: This study demonstrates that age as an important epidemiological factor, histopathological finding assessment, surgical status, radiological, location, grading, tumor morphology, treatment, outcome, recurrence of tumor, disease-free survival, and overall survival that was collected from patient archives in Clinical Oncology and nuclear medicine department in Zagazig University Hospitals. Therefore, this data can provide preliminary information for upcoming research. [ABSTRACT FROM AUTHOR]