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1. Effect of physical exercise on the hippocampus and global grey matter volume in breast cancer patients: A randomized controlled trial (PAM study)

Author

Haringhuizen, Annebeth W., van der Steeg, Wim A., Terheggen, Frederiek, Blanken-Peeters, Charlotte, Fliervoet, Harold, Schlooz-Vries, Margrethe S., Frakking, Tanja G., van Tilburg, Marc W.A., Oldenhuis, Corina, Sier, Maartje F., van der Pol, Carmen C., Tick, Lidwine W., van Holsteijn, Nel A., Koevoets, E.W., Geerlings, M.I., Monninkhof, E.M., Mandl, R., Witlox, L., van der Wall, E., Stuiver, M.M., Sonke, G.S., Velthuis, M.J., Jobsen, J.J., van der Palen, J., Bos, M.E.M.M., Göker, E., Menke-Pluijmers, M.B.E., Sommeijer, D.W., May, A.M., de Ruiter, M.B., and Schagen, S.B.

Published
2023
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3. Effect of physical exercise on the hippocampus and global grey matter volume in breast cancer patients: A randomized controlled trial (PAM study).

Author

Koevoets, E.W., Geerlings, M.I., Monninkhof, E.M., Mandl, R., Witlox, L., Wall, E. van der, Stuiver, M.M., Sonke, G.S., Velthuis, M.J., Jobsen, J.J., Palen, J. van der, Bos, Merijn, Göker, E., Menke-Pluijmers, M.B., Sommeijer, D.W., May, A.M., Schlooz-Vries, M.S., Ruiter, M.B de, Schagen, S.B., Koevoets, E.W., Geerlings, M.I., Monninkhof, E.M., Mandl, R., Witlox, L., Wall, E. van der, Stuiver, M.M., Sonke, G.S., Velthuis, M.J., Jobsen, J.J., Palen, J. van der, Bos, Merijn, Göker, E., Menke-Pluijmers, M.B., Sommeijer, D.W., May, A.M., Schlooz-Vries, M.S., Ruiter, M.B de, and Schagen, S.B.

Abstract

Item does not contain fulltext, BACKGROUND: Physical exercise in cancer patients is a promising intervention to improve cognition and increase brain volume, including hippocampal volume. We investigated whether a 6-month exercise intervention primarily impacts total hippocampal volume and additionally hippocampal subfield volumes, cortical thickness and grey matter volume in previously physically inactive breast cancer patients. Furthermore, we evaluated associations with verbal memory. METHODS: Chemotherapy-exposed breast cancer patients (stage I-III, 2-4 years post diagnosis) with cognitive problems were included and randomized in an exercise intervention (n = 70, age = 52.5 ± 9.0 years) or control group (n = 72, age = 53.2 ± 8.6 years). The intervention consisted of 2x1 hours/week of supervised aerobic and strength training and 2x1 hours/week Nordic or power walking. At baseline and at 6-month follow-up, volumetric brain measures were derived from 3D T1-weighted 3T magnetic resonance imaging scans, including hippocampal (subfield) volume (FreeSurfer), cortical thickness (CAT12), and grey matter volume (voxel-based morphometry CAT12). Physical fitness was measured with a cardiopulmonary exercise test. Memory functioning was measured with the Hopkins Verbal Learning Test-Revised (HVLT-R total recall) and Wordlist Learning of an online cognitive test battery, the Amsterdam Cognition Scan (ACS Wordlist Learning). An explorative analysis was conducted in highly fatigued patients (score of ≥ 39 on the symptom scale 'fatigue' of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire), as previous research in this dataset has shown that the intervention improved cognition only in these patients. RESULTS: Multiple regression analyses and voxel-based morphometry revealed no significant intervention effects on brain volume, although at baseline increased physical fitness was significantly related to larger brain volume (e.g., total hippocampal volume: R = 0.32, B = 21

Published
2023

4. Effect of physical exercise on the hippocampus and global grey matter volume in breast cancer patients:A randomized controlled trial (PAM study)

Author

Koevoets, E. W., Geerlings, M. I., Monninkhof, E. M., Mandl, R., Witlox, L., van der Wall, E., Stuiver, M. M., Sonke, G. S., Velthuis, M. J., Jobsen, J. J., van der Palen, J., Bos, M. E.M.M., Göker, E., Menke-Pluijmers, M. B.E., Sommeijer, D. W., May, A. M., Haringhuizen, Annebeth W., van der Steeg, Wim A., Terheggen, Frederiek, Blanken-Peeters, Charlotte, Fliervoet, Harold, Schlooz-Vries, Margrethe S., Frakking, Tanja G., van Tilburg, Marc W.A., Oldenhuis, Corina, Sier, Maartje F., van der Pol, Carmen C., Tick, Lidwine W., van Holsteijn, Nel A., de Ruiter, M. B., Schagen, S. B., Koevoets, E. W., Geerlings, M. I., Monninkhof, E. M., Mandl, R., Witlox, L., van der Wall, E., Stuiver, M. M., Sonke, G. S., Velthuis, M. J., Jobsen, J. J., van der Palen, J., Bos, M. E.M.M., Göker, E., Menke-Pluijmers, M. B.E., Sommeijer, D. W., May, A. M., Haringhuizen, Annebeth W., van der Steeg, Wim A., Terheggen, Frederiek, Blanken-Peeters, Charlotte, Fliervoet, Harold, Schlooz-Vries, Margrethe S., Frakking, Tanja G., van Tilburg, Marc W.A., Oldenhuis, Corina, Sier, Maartje F., van der Pol, Carmen C., Tick, Lidwine W., van Holsteijn, Nel A., de Ruiter, M. B., and Schagen, S. B.

Abstract

Background: Physical exercise in cancer patients is a promising intervention to improve cognition and increase brain volume, including hippocampal volume. We investigated whether a 6-month exercise intervention primarily impacts total hippocampal volume and additionally hippocampal subfield volumes, cortical thickness and grey matter volume in previously physically inactive breast cancer patients. Furthermore, we evaluated associations with verbal memory. Methods: Chemotherapy-exposed breast cancer patients (stage I-III, 2–4 years post diagnosis) with cognitive problems were included and randomized in an exercise intervention (n = 70, age = 52.5 ± 9.0 years) or control group (n = 72, age = 53.2 ± 8.6 years). The intervention consisted of 2x1 hours/week of supervised aerobic and strength training and 2x1 hours/week Nordic or power walking. At baseline and at 6-month follow-up, volumetric brain measures were derived from 3D T1-weighted 3T magnetic resonance imaging scans, including hippocampal (subfield) volume (FreeSurfer), cortical thickness (CAT12), and grey matter volume (voxel-based morphometry CAT12). Physical fitness was measured with a cardiopulmonary exercise test. Memory functioning was measured with the Hopkins Verbal Learning Test-Revised (HVLT-R total recall) and Wordlist Learning of an online cognitive test battery, the Amsterdam Cognition Scan (ACS Wordlist Learning). An explorative analysis was conducted in highly fatigued patients (score of ≥ 39 on the symptom scale ‘fatigue’ of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire), as previous research in this dataset has shown that the intervention improved cognition only in these patients. Results: Multiple regression analyses and voxel-based morphometry revealed no significant intervention effects on brain volume, although at baseline increased physical fitness was significantly related to larger brain volume (e.g., total hippocampal volume: R = 0.32, B =

Published
2023

6. Effect of physical exercise on the hippocampus and global grey matter volume in breast cancer patients: A randomized controlled trial (PAM study)

Author

Koevoets, E.W., primary, Geerlings, M.I., additional, Monninkhof, E.M., additional, Mandl, R., additional, Witlox, L., additional, van der Wall, E., additional, Stuiver, M.M., additional, Sonke, G.S., additional, Velthuis, M.J., additional, Jobsen, J.J., additional, van der Palen, J., additional, Bos, M.E.M.M., additional, Göker, E., additional, Menke-Pluijmers, M.B.E., additional, Sommeijer, D.W., additional, May, A.M., additional, de Ruiter, M.B., additional, Schagen, S.B., additional, Haringhuizen, Annebeth W., additional, van der Steeg, Wim A., additional, Terheggen, Frederiek, additional, Blanken-Peeters, Charlotte, additional, Fliervoet, Harold, additional, Schlooz-Vries, Margrethe S., additional, Frakking, Tanja G., additional, van Tilburg, Marc W.A., additional, Oldenhuis, Corina, additional, Sier, Maartje F., additional, van der Pol, Carmen C., additional, Tick, Lidwine W., additional, and van Holsteijn, Nel A., additional

Published
2023
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14. Functional connectome differences in individuals with hallucinations across the psychosis continuum

Author

Schutte, M.J.L. (Maya J. L.), Bohlken, M.M. (Marc M.), Collin, G. (Guusje), Abramovic, L. (Lucija), Boks, M.P.M. (Marco), Cahn, W. (Wiepke), Dauwan, M. (Meenakshi), van Dellen, E. (Edwin), van Haren, N.E.M. (Neeltje E. M.), Hugdahl, K. (Kenneth), Koops, S. (Sanne), Mandl, R. (René), Sommer, I.E.C. (Iris E. C.), Schutte, M.J.L. (Maya J. L.), Bohlken, M.M. (Marc M.), Collin, G. (Guusje), Abramovic, L. (Lucija), Boks, M.P.M. (Marco), Cahn, W. (Wiepke), Dauwan, M. (Meenakshi), van Dellen, E. (Edwin), van Haren, N.E.M. (Neeltje E. M.), Hugdahl, K. (Kenneth), Koops, S. (Sanne), Mandl, R. (René), and Sommer, I.E.C. (Iris E. C.)

Abstract

Hallucinations may arise from an imbalance between sensory and higher cognitive brain regions, reflected by alterations in functional connectivity. It is unknown whether hallucinations across the psychosis continuum exhibit similar alterations in functional connectivity, suggesting a common neural mechanism, or whether different mechanisms link to hallucinations across phenotypes. We acquired resting-state functional MRI scans of 483 participants, including 40 non-clinical individuals with hallucinations, 99 schizophrenia patients with hallucinations, 74 bipolar-I disorder patients with hallucinations, 42 bipolar-I disorder patients without hallucinations, and 228 healthy controls. The weighted connectivity matrices were compared using network-based statistics. Non-clinical individuals with hallucinations and schizophrenia patients with hallucinations exhibited increased connectivity, mainly among fronto-temporal and fronto-insula/cingulate areas compared to controls (P < 0.001 adjusted). Differential effects were observed for bipolar-I disorder patients with hallucinations versus controls, mainly characterized by decreased connectivity between fronto-temporal and fronto-striatal areas (P = 0.012 adjusted). No connectivity alterations were found between bipolar-I disorder patients without hallucinations and controls. Our results support the notion that hallucinations in non-clinical individuals and schizophrenia patients are related to altered interactions between sensory and higher-order cognitive brain regions. However, a different dysconnectivity pattern was observed for bipolar-I disorder patients with hallucinations, which implies a different neural mechanism across the psychosis continuum.

Published
2021
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15. Dissecting the phenotypic heterogeneity in sensory features in autism spectrum disorder: a factor mixture modelling approach

Author

Tillmann, J., Uljarevic, M., Crawley, D., Dumas, G., Loth, E., Murphy, D., Buitelaar, J., Charman, T., Ahmad, J., Ambrosino, S., Auyeung, B., Baumeister, S., Beckmann, C., Bourgeron, T., Bours, C., Brammer, M., Brandeis, D., Brogna, C., De Bruijn, Y., Chakrabarti, B., Cornelissen, I., Acqua, F. D., Ecker, C., Faulkner, J., Frouin, V., Garces, P., Goyard, D., Hayward, H., Hipp, J., Johnson, M. H., Jones, E. J. H., Kundu, P., Lai, M. -C., D'Ardhuy, X. L., Lombardo, M., Lythgoe, D. J., Mandl, R., Mason, L., Meyer-Lindenberg, A., Moessnang, C., Mueller, N., O'Dwyer, L., Oldehinkel, M., Oranje, B., Pandina, G., Persico, A. M., Ruggeri, B., Ruigrok, A., Sabet, J., Sacco, R., Toro, R., Tost, H., Waldman, J., Williams, S. C. R., Wooldridge, C., Zwiers, M. P., Tillmann, J [0000-0001-9574-9855], Apollo - University of Cambridge Repository, and University of Zurich

Subjects
Male, Neurology, medicine.medical_treatment, Audiology, Anxiety, lcsh:RC346-429, 1309 Developmental Biology, 2738 Psychiatry and Mental Health, 0302 clinical medicine, Autism spectrum disorder, Child, Uncategorized, 0303 health sciences, Confounding, Neuropsychology, 10058 Department of Child and Adolescent Psychiatry, communication symptoms, Psychiatry and Mental health, Phenotype, Regression Analysis, Female, medicine.symptom, Psychology, Adult, medicine.medical_specialty, Sensory processing, Adolescent, Sensation, 610 Medicine & health, Sensory system, Models, Biological, Sensory features, 2806 Developmental Neuroscience, 03 medical and health sciences, Young Adult, Social, Developmental Neuroscience, Heterogeneity, Social-communication symptoms, 1312 Molecular Biology, medicine, Humans, Molecular Biology, lcsh:Neurology. Diseases of the nervous system, 030304 developmental biology, Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], Genetic heterogeneity, Research, medicine.disease, Multivariate Analysis, 030217 neurology & neurosurgery, Developmental Biology
Abstract

Background Heterogeneity in the phenotypic presentation of autism spectrum disorder (ASD) is apparent in the profile and the severity of sensory features. Here, we applied factor mixture modelling (FMM) to test a multidimensional factor model of sensory processing in ASD. We aimed to identify homogeneous sensory subgroups in ASD that differ intrinsically in their severity along continuous factor scores. We also investigated sensory subgroups in relation to clinical variables: sex, age, IQ, social-communication symptoms, restricted and repetitive behaviours, adaptive functioning and symptoms of anxiety and attention-deficit/hyperactivity disorder. Methods Three hundred thirty-two children and adults with ASD between the ages of 6 and 30 years with IQs varying between 40 and 148 were included. First, three different confirmatory factor models were fit to the 38 items of the Short Sensory Profile (SSP). Then, latent class models (with two-to-six subgroups) were evaluated. The best performing factor model, the 7-factor structure, was subsequently used in two FMMs that varied in the number of subgroups: a two-subgroup, seven-factor model and a three-subgroup and seven-factor model. Results The ‘three-subgroup/seven-factor’ FMM was superior to all other models based on different fit criteria. Identified subgroups differed in sensory severity from severe, moderate to low. Accounting for the potential confounding effects of age and IQ, participants in these sensory subgroups had different levels of social-communicative symptoms, restricted and repetitive behaviours, adaptive functioning skills and symptoms of inattention and anxiety. Limitations Results were derived using a single parent-report measure of sensory features, the SSP, which limits the generalisability of findings. Conclusion Sensory features can be best described by three homogeneous sensory subgroups that differ in sensory severity gradients along seven continuous factor scores. Identified sensory subgroups were further differentiated by the severity of core and co-occurring symptoms, and level of adaptive functioning, providing novel evidence on the associated clinical correlates of sensory subgroups. These sensory subgroups provide a platform to further interrogate the neurobiological and genetic correlates of altered sensory processing in ASD.

Published
2020

16. Functional brain networks in the schizophrenia spectrum and bipolar disorder with psychosis

Author

van Dellen, E. (Edwin), Börner, C. (Corinna), Schutte, M. (Maya), van Montfort, S. (Simone), Abramovic, L. (Lucija), Boks, M.P.M. (Marco), Cahn, W. (Wiepke), van Haren, N. (Neeltje), Mandl, R. (René), Stam, C.J., Sommer, I. (Iris), van Dellen, E. (Edwin), Börner, C. (Corinna), Schutte, M. (Maya), van Montfort, S. (Simone), Abramovic, L. (Lucija), Boks, M.P.M. (Marco), Cahn, W. (Wiepke), van Haren, N. (Neeltje), Mandl, R. (René), Stam, C.J., and Sommer, I. (Iris)

Abstract

Psychotic experiences have been proposed to lie on a spectrum, ranging from subclinical experiences to treatment-resistant schizophrenia. We aimed to characterize functional connectivity and brain network characteristics in relation to the schizophrenia spectrum and bipolar disorder with psychosis to disentangle neural correlates to psychosis. Additionally, we studied antipsychotic medication and lithium effects on network characteristics. We analyzed functional connectivity strength and network topology in 487 resting-state functional MRI scans of individuals with schizophrenia spectrum disorder (SCZ), bipolar disorder with a history of psychotic experiences (BD), treatment-naïve subclinical psychosis (SCP), and healthy controls (HC). Since differences in connect

Published
2020
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17. Language in schizophrenia: relation with diagnosis, symptomatology and white matter tracts

Author

LS Immunologie, Leerstoel Postma, LS Psycholinguistiek, UiL OTS LAPD, de Boer, J N, van Hoogdalem, M, Mandl, R C W, Brummelman, J, Voppel, A E, Begemann, M J H, van Dellen, E, Wijnen, F N K, Sommer, I E C, LS Immunologie, Leerstoel Postma, LS Psycholinguistiek, UiL OTS LAPD, de Boer, J N, van Hoogdalem, M, Mandl, R C W, Brummelman, J, Voppel, A E, Begemann, M J H, van Dellen, E, Wijnen, F N K, and Sommer, I E C

Published
2020

19. Language in schizophrenia: relation with diagnosis, symptomatology and white matter tracts

Author

AIOS Psychiatrie, Onderzoeksgroep 8, Brain, Onderzoek Bob Oranje, Affectieve & Psychotische Med., Psychiatrie_Medisch, de Boer, J N, van Hoogdalem, M, Mandl, R C W, Brummelman, J, Voppel, A E, Begemann, M J H, van Dellen, E, Wijnen, F N K, Sommer, I E C, AIOS Psychiatrie, Onderzoeksgroep 8, Brain, Onderzoek Bob Oranje, Affectieve & Psychotische Med., Psychiatrie_Medisch, de Boer, J N, van Hoogdalem, M, Mandl, R C W, Brummelman, J, Voppel, A E, Begemann, M J H, van Dellen, E, Wijnen, F N K, and Sommer, I E C

Published
2020

20. T18. EFFECTS OF COGNITIVE REMEDIATION ON WHITE MATTER IN INDIVIDUALS AT ULTRA-HIGH RISK FOR PSYCHOSIS – A RANDOMIZED, CONTROLLED CLINICAL TRIAL

Author

Kristensen, Tina, Ebdrup, B, Hjorthøj, C, Mandl, R, Mitta, Raghava J, Møllegaard, Jepsen J, Fagerlund, Birgitte, Glenthøj, L, Wenneberg, C, Krakauer, K, Pantelis, C, Nordentoft, M, Kristensen, Tina, Ebdrup, B, Hjorthøj, C, Mandl, R, Mitta, Raghava J, Møllegaard, Jepsen J, Fagerlund, Birgitte, Glenthøj, L, Wenneberg, C, Krakauer, K, Pantelis, C, and Nordentoft, M

Abstract

Background Individuals at ultra-high risk for psychosis (UHR) present with subtle white matter alterations, which have been associated with clinical and functional outcome. The effect of cognitive remediation on white matter (WM) in UHR-individuals has not been investigated. Methods In a randomized, clinical intervention-trial (FOCUS), UHR-individuals aged 18–40 years were assigned to treatment as usual (TAU) or TAU plus cognitive remediation (CR) for 20 weeks. CR comprised 20 x 2-hour sessions of neurocognitive and social-cognitive training (SCIT). Primary outcome was whole brain fractional anisotropy (FA) derived from diffusion weighted imaging. Secondary outcomes pertained to regions of interest analyses. Planned post-hoc analyses explored dose-response effects of CR on WM. Main analyses of treatment effect of CR on primary and secondary outcomes were conducted using linear mixed models, assessing the interaction of timepoint by group (CR and TAU). Analyses were conducted according to the intention-to-treat principle. Results 111 UHR-individuals and 59 healthy controls were included. Attrition-rate was 30% at 6 months post-treatment follow-up. The CR group completed a mean of 12 hours of neurocognitive training. We found no effect of CR on whole-brain or regional FA. Planned post-hoc analyses revealed significant time*group (high- and low-attendance to CR) interactions in left superior corona radiata (p<0.01), left cingulum cingulate gyrus (P=0.03), and right superior longitudinal fasciculus (P<0,01), corrected. Specifically, when compared to UHR-individuals with high attendance (UHR-high >12 hours), those with low attendance (UHR-low <12 hours) had more co-morbid diagnoses, larger recreational smoking (nicotine and cannabis), more depressive and negative symptoms, and had significantly lower global FA at baseline, and showed a significant increase in FA after treatment. Furthermore, UHR-low displayed large effec

Published
2020

26. Widespread white matter microstructural differences in schizophrenia across 4322 individuals : Results from the ENIGMA Schizophrenia DTI Working Group

Author

Kelly, S., Jahanshad, N., Zalesky, A., Kochunov, P., Agartz, I., Alloza, C., Andreassen, O. A., Arango, C., Banaj, N., Bouix, S., Bousman, C. A., Brouwer, R. M., Bruggemann, J., Bustillo, J., Cahn, W., Calhoun, V., Cannon, D., Carr, V., Catts, S., Chen, J., Chen, J. X., Chen, X., Chiapponi, C., Cho, Kl K., Ciullo, V., Corvin, A. S., Crespo-Facorro, B., Cropley, V., De Rossi, P., Diaz-Caneja, C. M., Dickie, E. W., Ehrlich, S., Fan, F. M., Faskowitz, J., Fatouros-Bergman, H., Flyckt, L., Ford, J. M., Fouche, J. P., Fukunaga, M., Gill, M., Glahn, D. C., Gollub, R., Goudzwaard, E. D., Guo, H., Gur, R. E., Gur, R. C., Gurholt, T. P., Hashimoto, R., Hatton, S. N., Henskens, F. A., Hibar, D. P., Hickie, I. B., Hong, L. E., Horacek, J., Howells, F. M., Hulshoff Pol, H. E., Hyde, C. L., Isaev, D., Jablensky, A., Jansen, P. R., Janssen, J., Jönsson, E. G., Jung, L. A., Kahn, R. S., Kikinis, Z., Liu, K., Klauser, P., Knöchel, C., Kubicki, M., Lagopoulos, J., Langen, C., Lawrie, S., Lenroot, R. K., Lim, K. O., Lopez-Jaramillo, C., Lyall, A., Magnotta, V., Mandl, R. C.W., Mathalon, D. H., McCarley, R. W., McCarthy-Jones, S., McDonald, C., McEwen, S., McIntosh, A., Melicher, T., Mesholam-Gately, R. I., Michie, P. T., Mowry, B., Mueller, B. A., Newell, D. T., O'Donnell, P., Oertel-Knöchel, V., Oestreich, L., Paciga, S. A., Pantelis, C., Pasternak, O., Pearlson, G., Pellicano, G. R., Pereira, A., Pineda Zapata, J., Piras, F., Potkin, S. G., Preda, A., Rasser, P. E., Roalf, D. R., Roiz, R., Roos, A., Rotenberg, D., Satterthwaite, T. D., Savadjiev, P., Schall, U., Scott, R. J., Seal, M. L., Seidman, L. J., Shannon Weickert, C., Whelan, C. D., Shenton, M. E., Kwon, J. S., Spalletta, G., Spaniel, F., Sprooten, E., Stäblein, M., Stein, D. J., Sundram, S., Tan, Y., Tan, S., Tang, S., Temmingh, H. S., Westlye, L. T., Tønnesen, S., Tordesillas-Gutierrez, D., Doan, N. T., Vaidya, J., Van Haren, N. E.M., Vargas, C. D., Vecchio, D., Velakoulis, D., Voineskos, A., Voyvodic, J. Q., Wang, Z., Wan, P., Wei, D., Weickert, T. W., Whalley, H., White, T., Whitford, T. J., Wojcik, J. D., Xiang, H., Xie, Z., Yamamori, H., Yang, F., Yao, N., Zhang, G., Zhao, J., Van Erp, T. G.M., Turner, J., Thompson, P. M., Donohoe, G., Kelly, S., Jahanshad, N., Zalesky, A., Kochunov, P., Agartz, I., Alloza, C., Andreassen, O. A., Arango, C., Banaj, N., Bouix, S., Bousman, C. A., Brouwer, R. M., Bruggemann, J., Bustillo, J., Cahn, W., Calhoun, V., Cannon, D., Carr, V., Catts, S., Chen, J., Chen, J. X., Chen, X., Chiapponi, C., Cho, Kl K., Ciullo, V., Corvin, A. S., Crespo-Facorro, B., Cropley, V., De Rossi, P., Diaz-Caneja, C. M., Dickie, E. W., Ehrlich, S., Fan, F. M., Faskowitz, J., Fatouros-Bergman, H., Flyckt, L., Ford, J. M., Fouche, J. P., Fukunaga, M., Gill, M., Glahn, D. C., Gollub, R., Goudzwaard, E. D., Guo, H., Gur, R. E., Gur, R. C., Gurholt, T. P., Hashimoto, R., Hatton, S. N., Henskens, F. A., Hibar, D. P., Hickie, I. B., Hong, L. E., Horacek, J., Howells, F. M., Hulshoff Pol, H. E., Hyde, C. L., Isaev, D., Jablensky, A., Jansen, P. R., Janssen, J., Jönsson, E. G., Jung, L. A., Kahn, R. S., Kikinis, Z., Liu, K., Klauser, P., Knöchel, C., Kubicki, M., Lagopoulos, J., Langen, C., Lawrie, S., Lenroot, R. K., Lim, K. O., Lopez-Jaramillo, C., Lyall, A., Magnotta, V., Mandl, R. C.W., Mathalon, D. H., McCarley, R. W., McCarthy-Jones, S., McDonald, C., McEwen, S., McIntosh, A., Melicher, T., Mesholam-Gately, R. I., Michie, P. T., Mowry, B., Mueller, B. A., Newell, D. T., O'Donnell, P., Oertel-Knöchel, V., Oestreich, L., Paciga, S. A., Pantelis, C., Pasternak, O., Pearlson, G., Pellicano, G. R., Pereira, A., Pineda Zapata, J., Piras, F., Potkin, S. G., Preda, A., Rasser, P. E., Roalf, D. R., Roiz, R., Roos, A., Rotenberg, D., Satterthwaite, T. D., Savadjiev, P., Schall, U., Scott, R. J., Seal, M. L., Seidman, L. J., Shannon Weickert, C., Whelan, C. D., Shenton, M. E., Kwon, J. S., Spalletta, G., Spaniel, F., Sprooten, E., Stäblein, M., Stein, D. J., Sundram, S., Tan, Y., Tan, S., Tang, S., Temmingh, H. S., Westlye, L. T., Tønnesen, S., Tordesillas-Gutierrez, D., Doan, N. T., Vaidya, J., Van Haren, N. E.M., Vargas, C. D., Vecchio, D., Velakoulis, D., Voineskos, A., Voyvodic, J. Q., Wang, Z., Wan, P., Wei, D., Weickert, T. W., Whalley, H., White, T., Whitford, T. J., Wojcik, J. D., Xiang, H., Xie, Z., Yamamori, H., Yang, F., Yao, N., Zhang, G., Zhao, J., Van Erp, T. G.M., Turner, J., Thompson, P. M., and Donohoe, G.

Published
2018

27. Widespread white matter microstructural differences in schizophrenia across 4322 individuals: Results from the ENIGMA Schizophrenia DTI Working Group

Author

Kelly, S. (S.), Jahanshad, N. (Neda), Zalesky, A. (A.), Kochunov, P. (P.), Agartz, I. (Ingrid), Alloza, C. (C.), Andreassen, O.A. (O. A.), Arango, C. (C.), Banaj, N. (N.), Bouix, S. (S.), Bousman, C.A. (C. A.), Brouwer, R.M. (Rachel), Bruggemann, J. (J.), Bustillo, J., Cahn, W. (Wiepke), Calhoun, V.D. (Vince), Cannon, D. (D.), Carr, V.J. (Vaughan), Catts, S.V. (Stanley), Chen, J. (J.), Chen, J.-X. (J. X.), Chen, X. (X.), Chiapponi, C. (C.), Cho, K.K. (Kl K), Ciullo, V. (V.), Corvin, A. (Aiden), Crespo-Facorro, B. (Benedicto), Cropley, V. (V.), De Rossi, P. (P.), Diaz-Caneja, C.M. (C. M.), Dickie, E.W. (E. W.), Ehrlich, S.M. (Stefan), Fan, F.-M. (F. M.), Faskowitz, J. (J.), Fatouros-Bergman, H. (H.), Flyckt, L. (L.), Ford, J.M. (J. M.), Fouche, J.-P. (J. P.), Fukunaga, M. (Masaki), Gill, M. (M.), Glahn, D.C. (David), Gollub, R.L. (Randy), Goudzwaard, E.D. (E. D.), Guo, H. (H.), Gur, R.E. (Raquel), Gur, R.C. (R. C.), Gurholt, T.P. (T. P.), Hashimoto, R. (Ryota), Hatton, W., Henskens, F.A. (Frans), Hibar, D.P. (D. P.), Hickie, I.B. (Ian), Hong, L.E. (L. E.), Horacek, J. (J.), Howells, F.M. (F. M.), Hulshoff Pol, H.E. (Hilleke), Hyde, C.L. (C. L.), Isaev, D. (D.), Jablensky, A. (A.), Jansen, P.R. (P. R.), Janssen, J. (J.), Jönsson, E.G. (Erik), Jung, L.A. (L. A.), Kahn, R.S. (R. S.), Kikinis, Z. (Z.), Liu, K. (K.), Klauser, P. (P.), Knöchel, C. (C.), Kubicki, M. (M.), Lagopoulos, J. (Jim), Langen, C.D. (Carolyn), Lawrie, S. (Stephen), Lenroot, R.K. (Rhoshel), Lim, K.O. (Kelvin), Lopez-Jaramillo, C. (C.), Lyall, A. (A.), Magnotta, V., Mandl, R. (René), Mathalon, D.H. (D. H.), McCarley, R.W. (Robert), McCarthy-Jones, S. (S.), McDonald, C. (Colm), McEwen, S. (S.), McIntosh, A.M. (Andrew), Melicher, T. (T.), Mesholam-Gately, R.I. (Raquelle), Michie, P.T. (Patricia), Mowry, B.J. (Bryan J), Mueller, B.A. (Bryon ), Newell, D.T. (D. T.), O'Donnell, P. (P.), Oertel-Knöchel, V. (V.), Oestreich, L. (L.), Paciga, S.A. (S. A.), Pantelis, C. (Christos), Pasternak, O. (O.), Pearlson, G. (G.), Pellicano, G.R. (G. R.), Pereira, A. (A.), Pineda Zapata, J. (J.), Piras, F. (F.), Potkin, S.G. (Steven), Preda, A. (A.), Rasser, P.E. (P. E.), Roalf, D.R. (D. R.), Roiz, R. (R.), Roos, A. (A.), Rotenberg, D. (D.), Satterthwaite, T.D. (Theodore), Savadjiev, P. (P.), Schall, J.D. (Jeffrey), Scott, R.J. (R. J.), Seal, M.L. (M. L.), Seidman, L.J. (Larry), Shannon Weickert, C. (C.), Whelan, C.D. (Christopher), Shenton, M.E. (M. E.), Kwon, J.S. (J. S.), Spalletta, G. (Gianfranco), Spaniel, F. (F.), Sprooten, R. (Roy), Stäblein, M. (M.), Stein, D.J. (Dan), Sundram, S. (S.), Tan, Y. (Y.), Tan, S. (S.), Tang, S. (S.), Temmingh, H.S. (H. S.), Westlye, L.T. (Lars), Tønnesen, S. (S.), Tordesillas-Gutierrez, D. (Diana), Doan, N.T. (N. T.), Vaidya, J. (J.), Van Haren, N.E.M. (N. E.M.), Vargas, C.D. (C. D.), Vecchio, D. (D.), Velakoulis, D. (D.), Voineskos, A. (A.), Voyvodic, J.Q. (J. Q.), Wang, Z. (Z.), Wan, P. (P.), Wei, D. (D.), Weickert, T.W. (T. W.), Whalley, H. (H.), White, T.J.H. (Tonya), Whitford, T.J. (T. J.), Wojcik, J.D. (J. D.), Xiang, H. (H.), Xie, Z. (Z.), Yamamori, H. (H.), Yang, F. (F.), Yao, N. (N.), Zhang, G. (G.), Zhao, J. (J.), Erp, T.G.M. (Theo G.) van, Turner, J. (Jessica), Thompson, P.M. (P. M.), Donohoe, D.J. (Dennis), Kelly, S. (S.), Jahanshad, N. (Neda), Zalesky, A. (A.), Kochunov, P. (P.), Agartz, I. (Ingrid), Alloza, C. (C.), Andreassen, O.A. (O. A.), Arango, C. (C.), Banaj, N. (N.), Bouix, S. (S.), Bousman, C.A. (C. A.), Brouwer, R.M. (Rachel), Bruggemann, J. (J.), Bustillo, J., Cahn, W. (Wiepke), Calhoun, V.D. (Vince), Cannon, D. (D.), Carr, V.J. (Vaughan), Catts, S.V. (Stanley), Chen, J. (J.), Chen, J.-X. (J. X.), Chen, X. (X.), Chiapponi, C. (C.), Cho, K.K. (Kl K), Ciullo, V. (V.), Corvin, A. (Aiden), Crespo-Facorro, B. (Benedicto), Cropley, V. (V.), De Rossi, P. (P.), Diaz-Caneja, C.M. (C. M.), Dickie, E.W. (E. W.), Ehrlich, S.M. (Stefan), Fan, F.-M. (F. M.), Faskowitz, J. (J.), Fatouros-Bergman, H. (H.), Flyckt, L. (L.), Ford, J.M. (J. M.), Fouche, J.-P. (J. P.), Fukunaga, M. (Masaki), Gill, M. (M.), Glahn, D.C. (David), Gollub, R.L. (Randy), Goudzwaard, E.D. (E. D.), Guo, H. (H.), Gur, R.E. (Raquel), Gur, R.C. (R. C.), Gurholt, T.P. (T. P.), Hashimoto, R. (Ryota), Hatton, W., Henskens, F.A. (Frans), Hibar, D.P. (D. P.), Hickie, I.B. (Ian), Hong, L.E. (L. E.), Horacek, J. (J.), Howells, F.M. (F. M.), Hulshoff Pol, H.E. (Hilleke), Hyde, C.L. (C. L.), Isaev, D. (D.), Jablensky, A. (A.), Jansen, P.R. (P. R.), Janssen, J. (J.), Jönsson, E.G. (Erik), Jung, L.A. (L. A.), Kahn, R.S. (R. S.), Kikinis, Z. (Z.), Liu, K. (K.), Klauser, P. (P.), Knöchel, C. (C.), Kubicki, M. (M.), Lagopoulos, J. (Jim), Langen, C.D. (Carolyn), Lawrie, S. (Stephen), Lenroot, R.K. (Rhoshel), Lim, K.O. (Kelvin), Lopez-Jaramillo, C. (C.), Lyall, A. (A.), Magnotta, V., Mandl, R. (René), Mathalon, D.H. (D. H.), McCarley, R.W. (Robert), McCarthy-Jones, S. (S.), McDonald, C. (Colm), McEwen, S. (S.), McIntosh, A.M. (Andrew), Melicher, T. (T.), Mesholam-Gately, R.I. (Raquelle), Michie, P.T. (Patricia), Mowry, B.J. (Bryan J), Mueller, B.A. (Bryon ), Newell, D.T. (D. T.), O'Donnell, P. (P.), Oertel-Knöchel, V. (V.), Oestreich, L. (L.), Paciga, S.A. (S. A.), Pantelis, C. (Christos), Pasternak, O. (O.), Pearlson, G. (G.), Pellicano, G.R. (G. R.), Pereira, A. (A.), Pineda Zapata, J. (J.), Piras, F. (F.), Potkin, S.G. (Steven), Preda, A. (A.), Rasser, P.E. (P. E.), Roalf, D.R. (D. R.), Roiz, R. (R.), Roos, A. (A.), Rotenberg, D. (D.), Satterthwaite, T.D. (Theodore), Savadjiev, P. (P.), Schall, J.D. (Jeffrey), Scott, R.J. (R. J.), Seal, M.L. (M. L.), Seidman, L.J. (Larry), Shannon Weickert, C. (C.), Whelan, C.D. (Christopher), Shenton, M.E. (M. E.), Kwon, J.S. (J. S.), Spalletta, G. (Gianfranco), Spaniel, F. (F.), Sprooten, R. (Roy), Stäblein, M. (M.), Stein, D.J. (Dan), Sundram, S. (S.), Tan, Y. (Y.), Tan, S. (S.), Tang, S. (S.), Temmingh, H.S. (H. S.), Westlye, L.T. (Lars), Tønnesen, S. (S.), Tordesillas-Gutierrez, D. (Diana), Doan, N.T. (N. T.), Vaidya, J. (J.), Van Haren, N.E.M. (N. E.M.), Vargas, C.D. (C. D.), Vecchio, D. (D.), Velakoulis, D. (D.), Voineskos, A. (A.), Voyvodic, J.Q. (J. Q.), Wang, Z. (Z.), Wan, P. (P.), Wei, D. (D.), Weickert, T.W. (T. W.), Whalley, H. (H.), White, T.J.H. (Tonya), Whitford, T.J. (T. J.), Wojcik, J.D. (J. D.), Xiang, H. (H.), Xie, Z. (Z.), Yamamori, H. (H.), Yang, F. (F.), Yao, N. (N.), Zhang, G. (G.), Zhao, J. (J.), Erp, T.G.M. (Theo G.) van, Turner, J. (Jessica), Thompson, P.M. (P. M.), and Donohoe, D.J. (Dennis)

Abstract

The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly understood, and reported disease effects on the brain vary widely between studies. In an effort to identify commonalities across studies, we perform what we believe is the first ever large-scale coordinated study of WM microstructural differences in schizophrenia. Our analysis consisted of 2359 healthy controls and 1963 schizophrenia patients from 29 independent international studies; we harmonized the processing and statistical analyses of diffusion tensor imaging (DTI) data across sites and meta-analyzed effects across studies. Significant reductions in fractional anisotropy (FA) in schizophrenia patients were widespread, and detected in 20 of 25 regions of interest within a WM skeleton representing all major WM fasciculi. Effect sizes varied by region, peaking at (d=0.42) for the entire WM skeleton, driven more by peripheral areas as opposed to the core WM where regions of interest were defined. The anterior corona radiata (d=0.40) and corpus callosum (d=0.39), specifically its body (d=0.39) and genu (d=0.37), showed greatest effects. Significant decreases, to lesser degrees, were observed in almost all regions analyzed. Larger effect sizes were observed for FA than diffusivity measures; significantly higher mean and radial diffusivity was observed for schizophrenia patients compared with controls. No significant effects of age at onset of schizophrenia or medication dosage were detected. As the largest coordinated analysis of WM differences in a psychiatric disorder to date, the present study provides a robust profile of widespread WM abnormalities in schizophrenia patients worldwide. Interactive three-dimensional visualization of the results is available at www.enigma-viewer.org.

Published
2018
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28. Widespread white matter microstructural differences in schizophrenia across 4322 individuals: Results from the ENIGMA Schizophrenia DTI Working Group

Author

Onderzoeksgroep 1, Brain, Affectieve & Psychotische Med., Research Office, Onderzoek Bob Oranje, Onderzoeksgroep 11, Onderzoeksgroep 8, Onderzoeksgroep 4, Kelly, S., Jahanshad, N., Zalesky, A., Kochunov, P., Agartz, I., Alloza, C., Andreassen, O. A., Arango, C., Banaj, N., Bouix, S., Bousman, C. A., Brouwer, R. M., Bruggemann, J., Bustillo, J., Cahn, W., Calhoun, V., Cannon, D., Carr, V., Catts, S., Chen, J., Chen, J. X., Chen, X., Chiapponi, C., Cho, Kl K., Ciullo, V., Corvin, A. S., Crespo-Facorro, B., Cropley, V., De Rossi, P., Diaz-Caneja, C. M., Dickie, E. W., Ehrlich, S., Fan, F. M., Faskowitz, J., Fatouros-Bergman, H., Flyckt, L., Ford, J. M., Fouche, J. P., Fukunaga, M., Gill, M., Glahn, D. C., Gollub, R., Goudzwaard, E. D., Guo, H., Gur, R. E., Gur, R. C., Gurholt, T. P., Hashimoto, R., Hatton, S. N., Henskens, F. A., Hibar, D. P., Hickie, I. B., Hong, L. E., Horacek, J., Howells, F. M., Hulshoff Pol, H. E., Hyde, C. L., Isaev, D., Jablensky, A., Jansen, P. R., Janssen, J., Jönsson, E. G., Jung, L. A., Kahn, R. S., Kikinis, Z., Liu, K., Klauser, P., Knöchel, C., Kubicki, M., Lagopoulos, J., Langen, C., Lawrie, S., Lenroot, R. K., Lim, K. O., Lopez-Jaramillo, C., Lyall, A., Magnotta, V., Mandl, R. C.W., Mathalon, D. H., McCarley, R. W., McCarthy-Jones, S., McDonald, C., McEwen, S., McIntosh, A., Melicher, T., Mesholam-Gately, R. I., Michie, P. T., Mowry, B., Mueller, B. A., Newell, D. T., O'Donnell, P., Oertel-Knöchel, V., Oestreich, L., Paciga, S. A., Pantelis, C., Pasternak, O., Pearlson, G., Pellicano, G. R., Pereira, A., Pineda Zapata, J., Piras, F., Potkin, S. G., Preda, A., Rasser, P. E., Roalf, D. R., Roiz, R., Roos, A., Rotenberg, D., Satterthwaite, T. D., Savadjiev, P., Schall, U., Scott, R. J., Seal, M. L., Seidman, L. J., Shannon Weickert, C., Whelan, C. D., Shenton, M. E., Kwon, J. S., Spalletta, G., Spaniel, F., Sprooten, E., Stäblein, M., Stein, D. J., Sundram, S., Tan, Y., Tan, S., Tang, S., Temmingh, H. S., Westlye, L. T., Tønnesen, S., Tordesillas-Gutierrez, D., Doan, N. T., Vaidya, J., Van Haren, N. E.M., Vargas, C. D., Vecchio, D., Velakoulis, D., Voineskos, A., Voyvodic, J. Q., Wang, Z., Wan, P., Wei, D., Weickert, T. W., Whalley, H., White, T., Whitford, T. J., Wojcik, J. D., Xiang, H., Xie, Z., Yamamori, H., Yang, F., Yao, N., Zhang, G., Zhao, J., Van Erp, T. G.M., Turner, J., Thompson, P. M., Donohoe, G., Onderzoeksgroep 1, Brain, Affectieve & Psychotische Med., Research Office, Onderzoek Bob Oranje, Onderzoeksgroep 11, Onderzoeksgroep 8, Onderzoeksgroep 4, Kelly, S., Jahanshad, N., Zalesky, A., Kochunov, P., Agartz, I., Alloza, C., Andreassen, O. A., Arango, C., Banaj, N., Bouix, S., Bousman, C. A., Brouwer, R. M., Bruggemann, J., Bustillo, J., Cahn, W., Calhoun, V., Cannon, D., Carr, V., Catts, S., Chen, J., Chen, J. X., Chen, X., Chiapponi, C., Cho, Kl K., Ciullo, V., Corvin, A. S., Crespo-Facorro, B., Cropley, V., De Rossi, P., Diaz-Caneja, C. M., Dickie, E. W., Ehrlich, S., Fan, F. M., Faskowitz, J., Fatouros-Bergman, H., Flyckt, L., Ford, J. M., Fouche, J. P., Fukunaga, M., Gill, M., Glahn, D. C., Gollub, R., Goudzwaard, E. D., Guo, H., Gur, R. E., Gur, R. C., Gurholt, T. P., Hashimoto, R., Hatton, S. N., Henskens, F. A., Hibar, D. P., Hickie, I. B., Hong, L. E., Horacek, J., Howells, F. M., Hulshoff Pol, H. E., Hyde, C. L., Isaev, D., Jablensky, A., Jansen, P. R., Janssen, J., Jönsson, E. G., Jung, L. A., Kahn, R. S., Kikinis, Z., Liu, K., Klauser, P., Knöchel, C., Kubicki, M., Lagopoulos, J., Langen, C., Lawrie, S., Lenroot, R. K., Lim, K. O., Lopez-Jaramillo, C., Lyall, A., Magnotta, V., Mandl, R. C.W., Mathalon, D. H., McCarley, R. W., McCarthy-Jones, S., McDonald, C., McEwen, S., McIntosh, A., Melicher, T., Mesholam-Gately, R. I., Michie, P. T., Mowry, B., Mueller, B. A., Newell, D. T., O'Donnell, P., Oertel-Knöchel, V., Oestreich, L., Paciga, S. A., Pantelis, C., Pasternak, O., Pearlson, G., Pellicano, G. R., Pereira, A., Pineda Zapata, J., Piras, F., Potkin, S. G., Preda, A., Rasser, P. E., Roalf, D. R., Roiz, R., Roos, A., Rotenberg, D., Satterthwaite, T. D., Savadjiev, P., Schall, U., Scott, R. J., Seal, M. L., Seidman, L. J., Shannon Weickert, C., Whelan, C. D., Shenton, M. E., Kwon, J. S., Spalletta, G., Spaniel, F., Sprooten, E., Stäblein, M., Stein, D. J., Sundram, S., Tan, Y., Tan, S., Tang, S., Temmingh, H. S., Westlye, L. T., Tønnesen, S., Tordesillas-Gutierrez, D., Doan, N. T., Vaidya, J., Van Haren, N. E.M., Vargas, C. D., Vecchio, D., Velakoulis, D., Voineskos, A., Voyvodic, J. Q., Wang, Z., Wan, P., Wei, D., Weickert, T. W., Whalley, H., White, T., Whitford, T. J., Wojcik, J. D., Xiang, H., Xie, Z., Yamamori, H., Yang, F., Yao, N., Zhang, G., Zhao, J., Van Erp, T. G.M., Turner, J., Thompson, P. M., and Donohoe, G.

Published
2018

29. The EU-AIMS Longitudinal European Autism Project (LEAP): clinical characterisation

Author

Charman, T., Loth, E., Tillmann, J., Crawley, D., Wooldridge, C., Goyard, D., Ahmad, J., Auyeung, B., Ambrosino, S., Banaschewski, T., Baron-Cohen, S., Baumeister, S., Beckmann, C.F., Bolte, S., Bourgeron, T., Bours, C.C.A.H., Brammer, M., Brandeis, D., Brogna, C., Bruijn, Y. de, Chakrabarti, B., Cornelissen, I.M.M., Acqua, F.D., Dumas, G., Durston, S., Ecker, C., Faulkner, J., Frouin, V., Garces, P., Ham, L., Hayward, H., Hipp, J., Holt, R.J., Isaksson, J., Johnson, M.H., Jones, E.J.H., Kundu, P., Lai, M.C., D'Ardhuy, X.L., Lombardo, M.V., Lythgoe, D.J., Mandl, R., Mason, L., Meyer-Lindenberg, A., Moessnang, C., Mueller, N., O'Dwyer, L.G., Oldehinkel, M., Oranje, B., Pandina, G., Persico, A.M., Ruggeri, B., Ruigrok, A.N., Sabet, J., Sacco, R., San José Cáceres, A., Simonoff, E., Toro, R., Tost, H., Waldman, J., Williams, S.C.R., Zwiers, M.P., Spooren, W., Murphy, D.G.M., Buitelaar, J.K., Charman, T., Loth, E., Tillmann, J., Crawley, D., Wooldridge, C., Goyard, D., Ahmad, J., Auyeung, B., Ambrosino, S., Banaschewski, T., Baron-Cohen, S., Baumeister, S., Beckmann, C.F., Bolte, S., Bourgeron, T., Bours, C.C.A.H., Brammer, M., Brandeis, D., Brogna, C., Bruijn, Y. de, Chakrabarti, B., Cornelissen, I.M.M., Acqua, F.D., Dumas, G., Durston, S., Ecker, C., Faulkner, J., Frouin, V., Garces, P., Ham, L., Hayward, H., Hipp, J., Holt, R.J., Isaksson, J., Johnson, M.H., Jones, E.J.H., Kundu, P., Lai, M.C., D'Ardhuy, X.L., Lombardo, M.V., Lythgoe, D.J., Mandl, R., Mason, L., Meyer-Lindenberg, A., Moessnang, C., Mueller, N., O'Dwyer, L.G., Oldehinkel, M., Oranje, B., Pandina, G., Persico, A.M., Ruggeri, B., Ruigrok, A.N., Sabet, J., Sacco, R., San José Cáceres, A., Simonoff, E., Toro, R., Tost, H., Waldman, J., Williams, S.C.R., Zwiers, M.P., Spooren, W., Murphy, D.G.M., and Buitelaar, J.K.

Abstract

Contains fulltext : 177207.pdf (publisher's version ) (Open Access), BACKGROUND: The EU-AIMS Longitudinal European Autism Project (LEAP) is to date the largest multi-centre, multi-disciplinary observational study on biomarkers for autism spectrum disorder (ASD). The current paper describes the clinical characteristics of the LEAP cohort and examines age, sex and IQ differences in ASD core symptoms and common co-occurring psychiatric symptoms. A companion paper describes the overall design and experimental protocol and outlines the strategy to identify stratification biomarkers. METHODS: From six research centres in four European countries, we recruited 437 children and adults with ASD and 300 controls between the ages of 6 and 30 years with IQs varying between 50 and 148. We conducted in-depth clinical characterisation including a wide range of observational, interview and questionnaire measures of the ASD phenotype, as well as co-occurring psychiatric symptoms. RESULTS: The cohort showed heterogeneity in ASD symptom presentation, with only minimal to moderate site differences on core clinical and cognitive measures. On both parent-report interview and questionnaire measures, ASD symptom severity was lower in adults compared to children and adolescents. The precise pattern of differences varied across measures, but there was some evidence of both lower social symptoms and lower repetitive behaviour severity in adults. Males had higher ASD symptom scores than females on clinician-rated and parent interview diagnostic measures but not on parent-reported dimensional measures of ASD symptoms. In contrast, self-reported ASD symptom severity was higher in adults compared to adolescents, and in adult females compared to males. Higher scores on ASD symptom measures were moderately associated with lower IQ. Both inattentive and hyperactive/impulsive ADHD symptoms were lower in adults than in children and adolescents, and males with ASD had higher levels of inattentive and hyperactive/impulsive ADHD symptoms than females. CONCLUSIONS: The esta

Published
2017

30. The EU-AIMS Longitudinal European Autism Project (LEAP): design and methodologies to identify and validate stratification biomarkers for autism spectrum disorders

Author

Loth, E., Charman, T., Mason, L., Tillmann, J., Jones, E.J.H., Wooldridge, C., Ahmad, J., Auyeung, B., Brogna, C., Ambrosino, S., Banaschewski, T., Baron-Cohen, S., Baumeister, S., Beckmann, C.F., Brammer, M., Brandeis, D., Bolte, S., Bourgeron, T., Bours, C.C.A.H., Bruijn, Y.G.E. de, Chakrabarti, B., Crawley, D., Cornelissen, I.M.M., Acqua, F.D., Dumas, G., Durston, S., Ecker, C., Faulkner, J., Frouin, V., Garces, P., Goyard, D., Hayward, H., Ham, L.M., Hipp, J., Holt, R.J., Johnson, M.H., Isaksson, J., Kundu, P., Lai, M.C., X, L. D'Ardhuy, Lombardo, M.V., Lythgoe, D.J., Mandl, R., Meyer-Lindenberg, A., Moessnang, C., Mueller, N., O'Dwyer, L.G., Oldehinkel, M., Oranje, B., Pandina, G., Persico, A.M., Ruigrok, A.N., Ruggeri, B., Sabet, J., Sacco, R., San José Cáceres, A., Simonoff, E., Toro, R., Tost, H., Waldman, J., Williams, S.C.R., Zwiers, M.P., Spooren, W., Murphy, D.G.M., Buitelaar, J.K., Loth, E., Charman, T., Mason, L., Tillmann, J., Jones, E.J.H., Wooldridge, C., Ahmad, J., Auyeung, B., Brogna, C., Ambrosino, S., Banaschewski, T., Baron-Cohen, S., Baumeister, S., Beckmann, C.F., Brammer, M., Brandeis, D., Bolte, S., Bourgeron, T., Bours, C.C.A.H., Bruijn, Y.G.E. de, Chakrabarti, B., Crawley, D., Cornelissen, I.M.M., Acqua, F.D., Dumas, G., Durston, S., Ecker, C., Faulkner, J., Frouin, V., Garces, P., Goyard, D., Hayward, H., Ham, L.M., Hipp, J., Holt, R.J., Johnson, M.H., Isaksson, J., Kundu, P., Lai, M.C., X, L. D'Ardhuy, Lombardo, M.V., Lythgoe, D.J., Mandl, R., Meyer-Lindenberg, A., Moessnang, C., Mueller, N., O'Dwyer, L.G., Oldehinkel, M., Oranje, B., Pandina, G., Persico, A.M., Ruigrok, A.N., Ruggeri, B., Sabet, J., Sacco, R., San José Cáceres, A., Simonoff, E., Toro, R., Tost, H., Waldman, J., Williams, S.C.R., Zwiers, M.P., Spooren, W., Murphy, D.G.M., and Buitelaar, J.K.

Abstract

Contains fulltext : 177208.pdf (publisher's version ) (Open Access), BACKGROUND: The tremendous clinical and aetiological diversity among individuals with autism spectrum disorder (ASD) has been a major obstacle to the development of new treatments, as many may only be effective in particular subgroups. Precision medicine approaches aim to overcome this challenge by combining pathophysiologically based treatments with stratification biomarkers that predict which treatment may be most beneficial for particular individuals. However, so far, we have no single validated stratification biomarker for ASD. This may be due to the fact that most research studies primarily have focused on the identification of mean case-control differences, rather than within-group variability, and included small samples that were underpowered for stratification approaches. The EU-AIMS Longitudinal European Autism Project (LEAP) is to date the largest multi-centre, multi-disciplinary observational study worldwide that aims to identify and validate stratification biomarkers for ASD. METHODS: LEAP includes 437 children and adults with ASD and 300 individuals with typical development or mild intellectual disability. Using an accelerated longitudinal design, each participant is comprehensively characterised in terms of clinical symptoms, comorbidities, functional outcomes, neurocognitive profile, brain structure and function, biochemical markers and genomics. In addition, 51 twin-pairs (of which 36 had one sibling with ASD) are included to identify genetic and environmental factors in phenotypic variability. RESULTS: Here, we describe the demographic characteristics of the cohort, planned analytic stratification approaches, criteria and steps to validate candidate stratification markers, pre-registration procedures to increase transparency, standardisation and data robustness across all analyses, and share some 'lessons learnt'. A clinical characterisation of the cohort is given in the companion paper (Charman et al., accepted). CONCLUSION: We expect that LEAP wil

Published
2017

31. Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group

Author

Kelly, S, primary, Jahanshad, N, additional, Zalesky, A, additional, Kochunov, P, additional, Agartz, I, additional, Alloza, C, additional, Andreassen, O A, additional, Arango, C, additional, Banaj, N, additional, Bouix, S, additional, Bousman, C A, additional, Brouwer, R M, additional, Bruggemann, J, additional, Bustillo, J, additional, Cahn, W, additional, Calhoun, V, additional, Cannon, D, additional, Carr, V, additional, Catts, S, additional, Chen, J, additional, Chen, J-x, additional, Chen, X, additional, Chiapponi, C, additional, Cho, Kl K, additional, Ciullo, V, additional, Corvin, A S, additional, Crespo-Facorro, B, additional, Cropley, V, additional, De Rossi, P, additional, Diaz-Caneja, C M, additional, Dickie, E W, additional, Ehrlich, S, additional, Fan, F-m, additional, Faskowitz, J, additional, Fatouros-Bergman, H, additional, Flyckt, L, additional, Ford, J M, additional, Fouche, J-P, additional, Fukunaga, M, additional, Gill, M, additional, Glahn, D C, additional, Gollub, R, additional, Goudzwaard, E D, additional, Guo, H, additional, Gur, R E, additional, Gur, R C, additional, Gurholt, T P, additional, Hashimoto, R, additional, Hatton, S N, additional, Henskens, F A, additional, Hibar, D P, additional, Hickie, I B, additional, Hong, L E, additional, Horacek, J, additional, Howells, F M, additional, Hulshoff Pol, H E, additional, Hyde, C L, additional, Isaev, D, additional, Jablensky, A, additional, Jansen, P R, additional, Janssen, J, additional, Jönsson, E G, additional, Jung, L A, additional, Kahn, R S, additional, Kikinis, Z, additional, Liu, K, additional, Klauser, P, additional, Knöchel, C, additional, Kubicki, M, additional, Lagopoulos, J, additional, Langen, C, additional, Lawrie, S, additional, Lenroot, R K, additional, Lim, K O, additional, Lopez-Jaramillo, C, additional, Lyall, A, additional, Magnotta, V, additional, Mandl, R C W, additional, Mathalon, D H, additional, McCarley, R W, additional, McCarthy-Jones, S, additional, McDonald, C, additional, McEwen, S, additional, McIntosh, A, additional, Melicher, T, additional, Mesholam-Gately, R I, additional, Michie, P T, additional, Mowry, B, additional, Mueller, B A, additional, Newell, D T, additional, O'Donnell, P, additional, Oertel-Knöchel, V, additional, Oestreich, L, additional, Paciga, S A, additional, Pantelis, C, additional, Pasternak, O, additional, Pearlson, G, additional, Pellicano, G R, additional, Pereira, A, additional, Pineda Zapata, J, additional, Piras, F, additional, Potkin, S G, additional, Preda, A, additional, Rasser, P E, additional, Roalf, D R, additional, Roiz, R, additional, Roos, A, additional, Rotenberg, D, additional, Satterthwaite, T D, additional, Savadjiev, P, additional, Schall, U, additional, Scott, R J, additional, Seal, M L, additional, Seidman, L J, additional, Shannon Weickert, C, additional, Whelan, C D, additional, Shenton, M E, additional, Kwon, J S, additional, Spalletta, G, additional, Spaniel, F, additional, Sprooten, E, additional, Stäblein, M, additional, Stein, D J, additional, Sundram, S, additional, Tan, Y, additional, Tan, S, additional, Tang, S, additional, Temmingh, H S, additional, Westlye, L T, additional, Tønnesen, S, additional, Tordesillas-Gutierrez, D, additional, Doan, N T, additional, Vaidya, J, additional, van Haren, N E M, additional, Vargas, C D, additional, Vecchio, D, additional, Velakoulis, D, additional, Voineskos, A, additional, Voyvodic, J Q, additional, Wang, Z, additional, Wan, P, additional, Wei, D, additional, Weickert, T W, additional, Whalley, H, additional, White, T, additional, Whitford, T J, additional, Wojcik, J D, additional, Xiang, H, additional, Xie, Z, additional, Yamamori, H, additional, Yang, F, additional, Yao, N, additional, Zhang, G, additional, Zhao, J, additional, van Erp, T G M, additional, Turner, J, additional, Thompson, P M, additional, and Donohoe, G, additional

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2017
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33. The ENIGMA Consortium: Large-scale collaborative analyses of neuroimaging and genetic data

Author

Thompson, P.M. (Paul), Stein, J.L., Medland, S.E. (Sarah), Hibar, D.P. (Derrek), Vásquez, A.A. (Arias), Rentería, M.E. (Miguel), Toro, R. (Roberto), Jahanshad, N. (Neda), Schumann, G. (Gunter), Franke, B. (Barbara), Wright, M.J. (Margaret), Martin, N.G. (Nicholas), Agartz, I. (Ingrid), Alda, M. (Martin), Alhusaini, S. (Saud), Almasy, L. (Laura), Alpert, K. (Kathryn), Andreasen, N.C., Andreassen, O.A. (Ole), Apostolova, L.G. (Liana), Appel, K. (Katja), Armstrong, N.J. (Nicola), Aribisala, B. (Benjamin), Bastin, M.E. (Mark), Bauer, M. (Michael), Bearden, C.E. (Carrie), Bergmann, Ø. (Ørjan), Binder, E.B. (Elisabeth), Blangero, J. (John), Bockholt, H.J., Bøen, E. (Erlend), Bois, M. (Monique), Boomsma, D.I. (Dorret), Booth, T. (Tom), Bowman, I.J. (Ian), Bralten, L.B.C. (Linda), Brouwer, R.M. (Rachel), Brunner, H.G., Brohawn, D.G. (David), Buckner, M., Buitelaar, J.K. (Jan), Bulayeva, K. (Kazima), Bustillo, J., Calhoun, V.D. (Vince), Cannon, D.M. (Dara), Cantor, R.M., Carless, M.A. (Melanie), Caseras, X. (Xavier), Cavalleri, G. (Gianpiero), Chakravarty, M.M. (M. Mallar), Chang, K.D. (Kiki), Ching, C.R.K. (Christopher), Christoforou, A. (Andrea), Cichon, S. (Sven), Clark, V.P., Conrod, P. (Patricia), Coppola, D. (Domenico), Crespo-Facorro, B. (Benedicto), Curran, J.E. (Joanne), Czisch, M. (Michael), Deary, I.J. (Ian), Geus, E.J.C. (Eco) de, Braber, A. (Anouk) den, Delvecchio, G. (Giuseppe), Depondt, C. (Chantal), Haan, L. (Lieuwe) de, Zubicaray, G.I. (Greig) de, Dima, D. (Danai), Dimitrova, R. (Rali), Djurovic, S. (Srdjan), Dong, H. (Hongwei), Donohoe, D.J. (Dennis), Duggirala, A. (Aparna), Dyer, M.D. (Matthew), Ehrlich, S.M. (Stefan), Ekman, C.J. (Carl Johan), Elvsåshagen, T. (Torbjørn), Emsell, L. (Louise), Erk, S., Espeseth, T. (Thomas), Fagerness, J. (Jesen), Fears, S. (Scott), Fedko, I. (Iryna), Fernandez, G. (Guillén), Fisher, S.E. (Simon), Foroud, T. (Tatiana), Fox, P.T. (Peter), Francks, C. (Clyde), Frangou, S. (Sophia), Frey, E.M. (Eva Maria), Frodl, T. (Thomas), Frouin, V. (Vincent), Garavan, H. (Hugh), Giddaluru, S. (Sudheer), Glahn, D.C. (David), Godlewska, B. (Beata), Goldstein, R.Z. (Rita), Gollub, R.L. (Randy), Grabe, H.J. (Hans Jörgen), Grimm, O. (Oliver), Gruber, O. (Oliver), Guadalupe, T. (Tulio), Gur, R.E. (Raquel), Gur, R.C. (Ruben), Göring, H.H.H. (Harald), Hagenaars, S. (Saskia), Hajek, T. (Tomas), Hall, G.B. (Garry), Hall, J. (Jeremy), Hardy, J. (John), Hartman, C.A. (Catharina), Hass, J. (Johanna), Hatton, W., Haukvik, U.K. (Unn), Hegenscheid, K. (Katrin), Heinz, J. (Judith), Hickie, I.B. (Ian), Ho, B.C. (Beng ), Hoehn, D. (David), Hoekstra, P.J. (Pieter), Hollinshead, M. (Marisa), Holmes, A.J. (Avram), Homuth, G. (Georg), Hoogman, M. (Martine), Hong, L.E. (L.Elliot), Hosten, N. (Norbert), Hottenga, J.J. (Jouke Jan), Hulshoff Pol, H.E. (Hilleke), Hwang, K.S. (Kristy), Jack Jr., C.R. (Clifford), Jenkinson, S. (Sarah), Johnston, C., Jönsson, E.G. (Erik), Kahn, R.S. (René), Kasperaviciute, D. (Dalia), Kelly, S. (Steve), Kim, S. (Shinseog), Kochunov, P. (Peter), Koenders, L. (Laura), Krämer, B. (Bernd), Kwok, J.B.J. (John), Lagopoulos, J. (Jim), Laje, G. (Gonzalo), Landén, M. (Mikael), Landman, B.A. (Bennett), Lauriello, J., Lawrie, S. (Stephen), Lee, P.H. (Phil), Le Hellard, S. (Stephanie), Lemaître, H. (Herve), Leonardo, C.D. (Cassandra), Li, C.-S. (Chiang-shan), Liberg, B. (Benny), Liewald, D.C.M. (David), Liu, X. (Xinmin), Lopez, L.M. (Lorna), Loth, E. (Eva), Lourdusamy, A. (Anbarasu), Luciano, M. (Michelle), MacCiardi, F. (Fabio), Machielsen, M.W.J. (Marise), MacQueen, G.M. (Glenda), Malt, U.F. (Ulrik), Mandl, R. (René), Manoach, D.S. (Dara), Martinot, J.-L. (Jean-Luc), Matarin, M. (Mar), Mather, R., Mattheisen, M. (Manuel), Mattingsdal, M. (Morten), Meyer-Lindenberg, A., McDonald, C. (Colm), McIntosh, A.M. (Andrew), Mcmahon, F.J. (Francis J), Mcmahon, K.L. (Katie), Meisenzahl, E. (Eva), Melle, I. (Ingrid), Milaneschi, Y. (Yuri), Mohnke, S. (Sebastian), Montgomery, G.W. (Grant), Morris, D.W. (Derek W), Moses, E.K. (Eric), Mueller, B.A. (Bryon ), Muñoz Maniega, S. (Susana), Mühleisen, T.W. (Thomas), Müller-Myhsok, B. (Bertram), Mwangi, B. (Benson), Nauck, M. (Matthias), Nho, K. (Kwangsik), Nichols, T.E. (Thomas), Nilsson, L.G., Nugent, A.C. (Allison), Nyberg, L. (Lisa), Olvera, R.L. (Rene), Oosterlaan, J. (Jaap), Ophoff, R.A. (Roel), Pandolfo, M. (Massimo), Papalampropoulou-Tsiridou, M. (Melina), Papmeyer, M. (Martina), Paus, T. (Tomas), Pausova, Z. (Zdenka), Pearlson, G. (Godfrey), Penninx, B.W.J.H. (Brenda), Peterson, C.P. (Charles), Pfennig, A. (Andrea), Phillips, M. (Mary), Pike, G.B. (G Bruce), Poline, J.B. (Jean Baptiste), Potkin, S.G. (Steven), Pütz, B. (Benno), Ramasamy, A. (Adaikalavan), Rasmussen, J. (Jerod), Rietschel, M. (Marcella), Rijpkema, M. (Mark), Risacher, S.L. (Shannon), Roffman, J.L. (Joshua), Roiz-Santiañez, R. (Roberto), Romanczuk-Seiferth, N. (Nina), Rose, E.J. (Emma), Royle, N.A. (Natalie), Rujescu, D. (Dan), Ryten, M. (Mina), Sachdev, P.S. (Perminder), Salami, A. (Alireza), Satterthwaite, T.D. (Theodore), Savitz, J. (Jonathan), Saykin, A.J. (Andrew), Scanlon, C. (Cathy), Schmaal, L. (Lianne), Schnack, H. (Hugo), Schork, N.J. (Nicholas), Schulz, S.C. (S.Charles), Schür, R. (Remmelt), Seidman, L.J. (Larry), Shen, L. (Li), Shoemaker, L. (Lawrence), Simmons, A. (Andrew), Sisodiya, S.M. (Sanjay), Smith, C. (Colin), Smoller, J.W., Soares, J.C. (Jair), Sponheim, S.R. (Scott), Sprooten, R. (Roy), Starr, J.M. (John), Steen, V.M. (Vidar), Strakowski, S. (Stephen), Strike, L.T. (Lachlan), Sussmann, J. (Jessika), Sämann, P.G. (Philipp), Teumer, A. (Alexander), Toga, A.W. (Arthur), Tordesillas-Gutierrez, D. (Diana), Trabzuni, D. (Danyah), Trost, S. (Sarah), Turner, J. (Jessica), Heuvel, M. (Martijn) van den, Wee, N.J. (Nic) van der, Eijk, K.R. (Kristel) van, Erp, T.G.M. (Theo G.) van, Haren, N.E.M. (Neeltje E.) van, Ent, D. (Dennis) van 't, Tol, M.J.D. (Marie-José) van, Valdés Hernández, M.C. (Maria), Veltman, D.J. (Dick), Versace, A. (Amelia), Völzke, H. (Henry), Walker, R. (Robert), Walter, H.J. (Henrik), Wang, L. (Lei), Wardlaw, J.M. (J.), Weale, M.E. (Michael), Weiner, M.W. (Michael), Wen, W. (Wei), Westlye, L.T. (Lars), Whalley, H.C. (Heather), Whelan, C.D. (Christopher), White, T.J.H. (Tonya), Winkler, A.M. (Anderson), Wittfeld, K. (Katharina), Woldehawariat, G. (Girma), Björnsson, A. (Asgeir), Zilles, D. (David), Zwiers, M.P. (Marcel), Thalamuthu, A. (Anbupalam), Almeida, J.R. (Jorge), Schofield, C.J. (Christopher), Freimer, N.B. (Nelson), Lawrence, N.S. (Natalia), Drevets, D.A. (Douglas), Thompson, P.M. (Paul), Stein, J.L., Medland, S.E. (Sarah), Hibar, D.P. (Derrek), Vásquez, A.A. (Arias), Rentería, M.E. (Miguel), Toro, R. (Roberto), Jahanshad, N. (Neda), Schumann, G. (Gunter), Franke, B. (Barbara), Wright, M.J. (Margaret), Martin, N.G. (Nicholas), Agartz, I. (Ingrid), Alda, M. (Martin), Alhusaini, S. (Saud), Almasy, L. (Laura), Alpert, K. (Kathryn), Andreasen, N.C., Andreassen, O.A. (Ole), Apostolova, L.G. (Liana), Appel, K. (Katja), Armstrong, N.J. (Nicola), Aribisala, B. (Benjamin), Bastin, M.E. (Mark), Bauer, M. (Michael), Bearden, C.E. (Carrie), Bergmann, Ø. (Ørjan), Binder, E.B. (Elisabeth), Blangero, J. (John), Bockholt, H.J., Bøen, E. (Erlend), Bois, M. (Monique), Boomsma, D.I. (Dorret), Booth, T. (Tom), Bowman, I.J. (Ian), Bralten, L.B.C. (Linda), Brouwer, R.M. (Rachel), Brunner, H.G., Brohawn, D.G. (David), Buckner, M., Buitelaar, J.K. (Jan), Bulayeva, K. (Kazima), Bustillo, J., Calhoun, V.D. (Vince), Cannon, D.M. (Dara), Cantor, R.M., Carless, M.A. (Melanie), Caseras, X. (Xavier), Cavalleri, G. (Gianpiero), Chakravarty, M.M. (M. Mallar), Chang, K.D. (Kiki), Ching, C.R.K. (Christopher), Christoforou, A. (Andrea), Cichon, S. (Sven), Clark, V.P., Conrod, P. (Patricia), Coppola, D. (Domenico), Crespo-Facorro, B. (Benedicto), Curran, J.E. (Joanne), Czisch, M. (Michael), Deary, I.J. (Ian), Geus, E.J.C. (Eco) de, Braber, A. (Anouk) den, Delvecchio, G. (Giuseppe), Depondt, C. (Chantal), Haan, L. (Lieuwe) de, Zubicaray, G.I. (Greig) de, Dima, D. (Danai), Dimitrova, R. (Rali), Djurovic, S. (Srdjan), Dong, H. (Hongwei), Donohoe, D.J. (Dennis), Duggirala, A. (Aparna), Dyer, M.D. (Matthew), Ehrlich, S.M. (Stefan), Ekman, C.J. (Carl Johan), Elvsåshagen, T. (Torbjørn), Emsell, L. (Louise), Erk, S., Espeseth, T. (Thomas), Fagerness, J. (Jesen), Fears, S. (Scott), Fedko, I. (Iryna), Fernandez, G. (Guillén), Fisher, S.E. (Simon), Foroud, T. (Tatiana), Fox, P.T. (Peter), Francks, C. (Clyde), Frangou, S. (Sophia), Frey, E.M. (Eva Maria), Frodl, T. (Thomas), Frouin, V. (Vincent), Garavan, H. (Hugh), Giddaluru, S. (Sudheer), Glahn, D.C. (David), Godlewska, B. (Beata), Goldstein, R.Z. (Rita), Gollub, R.L. (Randy), Grabe, H.J. (Hans Jörgen), Grimm, O. (Oliver), Gruber, O. (Oliver), Guadalupe, T. (Tulio), Gur, R.E. (Raquel), Gur, R.C. (Ruben), Göring, H.H.H. (Harald), Hagenaars, S. (Saskia), Hajek, T. (Tomas), Hall, G.B. (Garry), Hall, J. (Jeremy), Hardy, J. (John), Hartman, C.A. (Catharina), Hass, J. (Johanna), Hatton, W., Haukvik, U.K. (Unn), Hegenscheid, K. (Katrin), Heinz, J. (Judith), Hickie, I.B. (Ian), Ho, B.C. (Beng ), Hoehn, D. (David), Hoekstra, P.J. (Pieter), Hollinshead, M. (Marisa), Holmes, A.J. (Avram), Homuth, G. (Georg), Hoogman, M. (Martine), Hong, L.E. (L.Elliot), Hosten, N. (Norbert), Hottenga, J.J. (Jouke Jan), Hulshoff Pol, H.E. (Hilleke), Hwang, K.S. (Kristy), Jack Jr., C.R. (Clifford), Jenkinson, S. (Sarah), Johnston, C., Jönsson, E.G. (Erik), Kahn, R.S. (René), Kasperaviciute, D. (Dalia), Kelly, S. (Steve), Kim, S. (Shinseog), Kochunov, P. (Peter), Koenders, L. (Laura), Krämer, B. (Bernd), Kwok, J.B.J. (John), Lagopoulos, J. (Jim), Laje, G. (Gonzalo), Landén, M. (Mikael), Landman, B.A. (Bennett), Lauriello, J., Lawrie, S. (Stephen), Lee, P.H. (Phil), Le Hellard, S. (Stephanie), Lemaître, H. (Herve), Leonardo, C.D. (Cassandra), Li, C.-S. (Chiang-shan), Liberg, B. (Benny), Liewald, D.C.M. (David), Liu, X. (Xinmin), Lopez, L.M. (Lorna), Loth, E. (Eva), Lourdusamy, A. (Anbarasu), Luciano, M. (Michelle), MacCiardi, F. (Fabio), Machielsen, M.W.J. (Marise), MacQueen, G.M. (Glenda), Malt, U.F. (Ulrik), Mandl, R. (René), Manoach, D.S. (Dara), Martinot, J.-L. (Jean-Luc), Matarin, M. (Mar), Mather, R., Mattheisen, M. (Manuel), Mattingsdal, M. (Morten), Meyer-Lindenberg, A., McDonald, C. (Colm), McIntosh, A.M. (Andrew), Mcmahon, F.J. (Francis J), Mcmahon, K.L. (Katie), Meisenzahl, E. (Eva), Melle, I. (Ingrid), Milaneschi, Y. (Yuri), Mohnke, S. (Sebastian), Montgomery, G.W. (Grant), Morris, D.W. (Derek W), Moses, E.K. (Eric), Mueller, B.A. (Bryon ), Muñoz Maniega, S. (Susana), Mühleisen, T.W. (Thomas), Müller-Myhsok, B. (Bertram), Mwangi, B. (Benson), Nauck, M. (Matthias), Nho, K. (Kwangsik), Nichols, T.E. (Thomas), Nilsson, L.G., Nugent, A.C. (Allison), Nyberg, L. (Lisa), Olvera, R.L. (Rene), Oosterlaan, J. (Jaap), Ophoff, R.A. (Roel), Pandolfo, M. (Massimo), Papalampropoulou-Tsiridou, M. (Melina), Papmeyer, M. (Martina), Paus, T. (Tomas), Pausova, Z. (Zdenka), Pearlson, G. (Godfrey), Penninx, B.W.J.H. (Brenda), Peterson, C.P. (Charles), Pfennig, A. (Andrea), Phillips, M. (Mary), Pike, G.B. (G Bruce), Poline, J.B. (Jean Baptiste), Potkin, S.G. (Steven), Pütz, B. (Benno), Ramasamy, A. (Adaikalavan), Rasmussen, J. (Jerod), Rietschel, M. (Marcella), Rijpkema, M. (Mark), Risacher, S.L. (Shannon), Roffman, J.L. (Joshua), Roiz-Santiañez, R. (Roberto), Romanczuk-Seiferth, N. (Nina), Rose, E.J. (Emma), Royle, N.A. (Natalie), Rujescu, D. (Dan), Ryten, M. (Mina), Sachdev, P.S. (Perminder), Salami, A. (Alireza), Satterthwaite, T.D. (Theodore), Savitz, J. (Jonathan), Saykin, A.J. (Andrew), Scanlon, C. (Cathy), Schmaal, L. (Lianne), Schnack, H. (Hugo), Schork, N.J. (Nicholas), Schulz, S.C. (S.Charles), Schür, R. (Remmelt), Seidman, L.J. (Larry), Shen, L. (Li), Shoemaker, L. (Lawrence), Simmons, A. (Andrew), Sisodiya, S.M. (Sanjay), Smith, C. (Colin), Smoller, J.W., Soares, J.C. (Jair), Sponheim, S.R. (Scott), Sprooten, R. (Roy), Starr, J.M. (John), Steen, V.M. (Vidar), Strakowski, S. (Stephen), Strike, L.T. (Lachlan), Sussmann, J. (Jessika), Sämann, P.G. (Philipp), Teumer, A. (Alexander), Toga, A.W. (Arthur), Tordesillas-Gutierrez, D. (Diana), Trabzuni, D. (Danyah), Trost, S. (Sarah), Turner, J. (Jessica), Heuvel, M. (Martijn) van den, Wee, N.J. (Nic) van der, Eijk, K.R. (Kristel) van, Erp, T.G.M. (Theo G.) van, Haren, N.E.M. (Neeltje E.) van, Ent, D. (Dennis) van 't, Tol, M.J.D. (Marie-José) van, Valdés Hernández, M.C. (Maria), Veltman, D.J. (Dick), Versace, A. (Amelia), Völzke, H. (Henry), Walker, R. (Robert), Walter, H.J. (Henrik), Wang, L. (Lei), Wardlaw, J.M. (J.), Weale, M.E. (Michael), Weiner, M.W. (Michael), Wen, W. (Wei), Westlye, L.T. (Lars), Whalley, H.C. (Heather), Whelan, C.D. (Christopher), White, T.J.H. (Tonya), Winkler, A.M. (Anderson), Wittfeld, K. (Katharina), Woldehawariat, G. (Girma), Björnsson, A. (Asgeir), Zilles, D. (David), Zwiers, M.P. (Marcel), Thalamuthu, A. (Anbupalam), Almeida, J.R. (Jorge), Schofield, C.J. (Christopher), Freimer, N.B. (Nelson), Lawrence, N.S. (Natalia), and Drevets, D.A. (Douglas)

Abstract

The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way.

Published
2014
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34. The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data

Author

Thompson, P.M., Stein, J.L., Medland, S.E., Hibar, D.P., Vasquez, A.A., Renteria, M.E., Toro, R., Jahanshad, N., Schumann, G., Franke, B., Wright, M.J., Martin, N.G., Agartz, I., Alda, M., Alhusaini, S., Almasy, L., Almeida, J., Alpert, K., Andreasen, N.C., Andreassen, O.A., Apostolova, L.G., Appel, K., Armstrong, N.J., Aribisala, B., Bastin, M.E., Bauer, M., Bearden, C.E., Bergmann, O., Binder, E.B., Blangero, J., Bockholt, H.J., Boen, E., Bois, C., Boomsma, D.I., Booth, T., Bowman, I.J., Bralten, J., Brouwer, R.M., Brunner, H.G., Brohawn, D.G., Buckner, R.L., Buitelaar, J., Bulayeva, K., Bustillo, J.R., Calhoun, V.D., Cannon, D.M., Cantor, R.M., Carless, M.A., Caseras, X., Cavalleri, G.L., Chakravarty, M.M., Chang, K.D., Ching, C.R., Christoforou, A., Cichon, S., Clark, V.P., Conrod, P., Coppola, G., Crespo-Facorro, B., Curran, J.E., Czisch, M., Deary, I.J., de Geus, E.J., den Braber, A., Delvecchio, G., Depondt, C., de Haan, L., de Zubicaray, G.I., Dima, D., Dimitrova, R., Djurovic, S., Dong, H., Donohoe, G., Duggirala, R., Dyer, T.D., Ehrlich, S., Ekman, C.J., Elvsashagen, T., Emsell, L., Erk, S., Espeseth, T., Fagerness, J., Fears, S., Fedko, I., Fernandez, G., Fisher, S.E., Foroud, T., Fox, P.T., Francks, C., Frangou, S., Frey, E.M., Frodl, T., Frouin, V., Garavan, H., Giddaluru, S., Glahn, D.C., Godlewska, B., Goldstein, R.Z., Gollub, R.L., Grabe, H.J., Grimm, O., Gruber, O., Guadalupe, T., Gur, R.E., Gur, R.C., Goring, H.H., Hagenaars, S., Hajek, T., Hall, G.B., Hall, J., Hardy, J., Hartman, C.A., Hass, J., Hatton, S.N., Haukvik, U.K., Hegenscheid, K., Heinz, A., Hickie, I.B., Ho, B.C., Hoehn, D., Hoekstra, P.J., Hollinshead, M., Holmes, A.J., Homuth, G., Hoogman, M., Hong, L.E., Hosten, N., Hottenga, J.J., Hulshoff Pol, H.E., Hwang, K.S., Jack, C.R., Jenkinson, M., Johnston, C., Jonsson, E.G., Kahn, R.S., Kasperaviciute, D., Kelly, S., Kim, S., Kochunov, P., Koenders, L., Kramer, B., Kwok, J.B., Lagopoulos, J., Laje, G., Landen, M., Landman, B.A., Lauriello, J., Lawrie, S.M., Lee, P.H., Le Hellard, S., Lemaitre, H., Leonardo, C.D., Li, C.S., Liberg, B., Liewald, D.C., Liu, X., Lopez, L.M., Loth, E., Lourdusamy, A., Luciano, M., Macciardi, F., Machielsen, M.W., Macqueen, G.M., Malt, U.F., Mandl, R., Manoach, D.S., Martinot, J.L., Matarin, M., Mather, K.A., Mattheisen, M., Mattingsdal, M., Meyer-Lindenberg, A., McDonald, C., McIntosh, A.M., McMahon, F.J., McMahon, K.L., Meisenzahl, E., Melle, I., Milaneschi, Y., Mohnke, S., Montgomery, G.W., Morris, D.W., Moses, E.K., Mueller, B.A., Munoz Maniega, S., Muhleisen, T.W., Muller-Myhsok, B., Mwangi, B., Nauck, M., Nho, K., Nichols, T.E., Nilsson, L.G., Nugent, A.C., Nyberg, L., Olvera, R.L., Oosterlaan, J., Ophoff, R.A., Pandolfo, M., Papalampropoulou-Tsiridou, M., Papmeyer, M., Paus, T., Pausova, Z., Pearlson, G.D., Penninx, B.W., Peterson, C.P., Pfennig, A., Phillips, M., Pike, G.B., Poline, J.B., Potkin, S.G., Putz, B., Ramasamy, A., Rasmussen, J., Rietschel, M., Rijpkema, M., Risacher, S.L., Roffman, J.L., Roiz-Santianez, R., Romanczuk-Seiferth, N., Rose, E.J., Royle, N.A., Rujescu, D., Ryten, M., Sachdev, P.S., Salami, A., Satterthwaite, T.D., Savitz, J., Saykin, A.J., Scanlon, C., Schmaal, L., Schnack, H.G., Schork, A.J., Schulz, S.C., Schur, R., Seidman, L., Shen, L., Shoemaker, J.M., Simmons, A., Sisodiya, S.M., Smith, C., Smoller, J.W., Soares, J.C., Sponheim, S.R., Sprooten, E., Starr, J.M., Steen, V.M., Strakowski, S., Strike, L., Sussmann, J., Samann, P.G., Teumer, A., Toga, A.W., Tordesillas-Gutierrez, D., Trabzuni, D., Trost, S., Turner, J., Van den Heuvel, M., van der Wee, N.J., van Eijk, K., van Erp, T.G., van Haren, N.E., van 't Ent, D., van Tol, M.J., Valdes Hernandez, M.C., Veltman, D.J., Versace, A., Volzke, H., Walker, R., Walter, H., Wang, L., Wardlaw, J.M., Weale, M.E., Weiner, M.W., Wen, W., Westlye, L.T., Whalley, H.C., Whelan, C.D., White, T., Winkler, A.M., Wittfeld, K., Woldehawariat, G., Wolf, C., Zilles, D., Zwiers, M.P., Thalamuthu, A., Schofield, P.R., Freimer, N.B., Lawrence, N.S., Drevets, W., Thompson, P.M., Stein, J.L., Medland, S.E., Hibar, D.P., Vasquez, A.A., Renteria, M.E., Toro, R., Jahanshad, N., Schumann, G., Franke, B., Wright, M.J., Martin, N.G., Agartz, I., Alda, M., Alhusaini, S., Almasy, L., Almeida, J., Alpert, K., Andreasen, N.C., Andreassen, O.A., Apostolova, L.G., Appel, K., Armstrong, N.J., Aribisala, B., Bastin, M.E., Bauer, M., Bearden, C.E., Bergmann, O., Binder, E.B., Blangero, J., Bockholt, H.J., Boen, E., Bois, C., Boomsma, D.I., Booth, T., Bowman, I.J., Bralten, J., Brouwer, R.M., Brunner, H.G., Brohawn, D.G., Buckner, R.L., Buitelaar, J., Bulayeva, K., Bustillo, J.R., Calhoun, V.D., Cannon, D.M., Cantor, R.M., Carless, M.A., Caseras, X., Cavalleri, G.L., Chakravarty, M.M., Chang, K.D., Ching, C.R., Christoforou, A., Cichon, S., Clark, V.P., Conrod, P., Coppola, G., Crespo-Facorro, B., Curran, J.E., Czisch, M., Deary, I.J., de Geus, E.J., den Braber, A., Delvecchio, G., Depondt, C., de Haan, L., de Zubicaray, G.I., Dima, D., Dimitrova, R., Djurovic, S., Dong, H., Donohoe, G., Duggirala, R., Dyer, T.D., Ehrlich, S., Ekman, C.J., Elvsashagen, T., Emsell, L., Erk, S., Espeseth, T., Fagerness, J., Fears, S., Fedko, I., Fernandez, G., Fisher, S.E., Foroud, T., Fox, P.T., Francks, C., Frangou, S., Frey, E.M., Frodl, T., Frouin, V., Garavan, H., Giddaluru, S., Glahn, D.C., Godlewska, B., Goldstein, R.Z., Gollub, R.L., Grabe, H.J., Grimm, O., Gruber, O., Guadalupe, T., Gur, R.E., Gur, R.C., Goring, H.H., Hagenaars, S., Hajek, T., Hall, G.B., Hall, J., Hardy, J., Hartman, C.A., Hass, J., Hatton, S.N., Haukvik, U.K., Hegenscheid, K., Heinz, A., Hickie, I.B., Ho, B.C., Hoehn, D., Hoekstra, P.J., Hollinshead, M., Holmes, A.J., Homuth, G., Hoogman, M., Hong, L.E., Hosten, N., Hottenga, J.J., Hulshoff Pol, H.E., Hwang, K.S., Jack, C.R., Jenkinson, M., Johnston, C., Jonsson, E.G., Kahn, R.S., Kasperaviciute, D., Kelly, S., Kim, S., Kochunov, P., Koenders, L., Kramer, B., Kwok, J.B., Lagopoulos, J., Laje, G., Landen, M., Landman, B.A., Lauriello, J., Lawrie, S.M., Lee, P.H., Le Hellard, S., Lemaitre, H., Leonardo, C.D., Li, C.S., Liberg, B., Liewald, D.C., Liu, X., Lopez, L.M., Loth, E., Lourdusamy, A., Luciano, M., Macciardi, F., Machielsen, M.W., Macqueen, G.M., Malt, U.F., Mandl, R., Manoach, D.S., Martinot, J.L., Matarin, M., Mather, K.A., Mattheisen, M., Mattingsdal, M., Meyer-Lindenberg, A., McDonald, C., McIntosh, A.M., McMahon, F.J., McMahon, K.L., Meisenzahl, E., Melle, I., Milaneschi, Y., Mohnke, S., Montgomery, G.W., Morris, D.W., Moses, E.K., Mueller, B.A., Munoz Maniega, S., Muhleisen, T.W., Muller-Myhsok, B., Mwangi, B., Nauck, M., Nho, K., Nichols, T.E., Nilsson, L.G., Nugent, A.C., Nyberg, L., Olvera, R.L., Oosterlaan, J., Ophoff, R.A., Pandolfo, M., Papalampropoulou-Tsiridou, M., Papmeyer, M., Paus, T., Pausova, Z., Pearlson, G.D., Penninx, B.W., Peterson, C.P., Pfennig, A., Phillips, M., Pike, G.B., Poline, J.B., Potkin, S.G., Putz, B., Ramasamy, A., Rasmussen, J., Rietschel, M., Rijpkema, M., Risacher, S.L., Roffman, J.L., Roiz-Santianez, R., Romanczuk-Seiferth, N., Rose, E.J., Royle, N.A., Rujescu, D., Ryten, M., Sachdev, P.S., Salami, A., Satterthwaite, T.D., Savitz, J., Saykin, A.J., Scanlon, C., Schmaal, L., Schnack, H.G., Schork, A.J., Schulz, S.C., Schur, R., Seidman, L., Shen, L., Shoemaker, J.M., Simmons, A., Sisodiya, S.M., Smith, C., Smoller, J.W., Soares, J.C., Sponheim, S.R., Sprooten, E., Starr, J.M., Steen, V.M., Strakowski, S., Strike, L., Sussmann, J., Samann, P.G., Teumer, A., Toga, A.W., Tordesillas-Gutierrez, D., Trabzuni, D., Trost, S., Turner, J., Van den Heuvel, M., van der Wee, N.J., van Eijk, K., van Erp, T.G., van Haren, N.E., van 't Ent, D., van Tol, M.J., Valdes Hernandez, M.C., Veltman, D.J., Versace, A., Volzke, H., Walker, R., Walter, H., Wang, L., Wardlaw, J.M., Weale, M.E., Weiner, M.W., Wen, W., Westlye, L.T., Whalley, H.C., Whelan, C.D., White, T., Winkler, A.M., Wittfeld, K., Woldehawariat, G., Wolf, C., Zilles, D., Zwiers, M.P., Thalamuthu, A., Schofield, P.R., Freimer, N.B., Lawrence, N.S., and Drevets, W.

Abstract

The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way.

Published
2014

35. The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data

Author

Thompson, PM, Stein, JL, Medland, SE, Hibar, DP, Vasquez, AA, Renteria, ME, Toro, R, Jahanshad, N, Schumann, G, Franke, B, Wright, MJ, Martin, NG, Agartz, I, Alda, M, Alhusaini, S, Almasy, L, Almeida, J, Alpert, K, Andreasen, NC, Andreassen, OA, Apostolova, LG, Appel, K, Armstrong, NJ, Aribisala, B, Bastin, ME, Bauer, M, Bearden, CE, Bergmann, O, Binder, EB, Blangero, J, Bockholt, HJ, Boen, E, Bois, C, Boomsma, DI, Booth, T, Bowman, IJ, Bralten, J, Brouwer, RM, Brunner, HG, Brohawn, DG, Buckner, RL, Buitelaar, J, Bulayeva, K, Bustillo, JR, Calhoun, VD, Cannon, DM, Cantor, RM, Carless, MA, Caseras, X, Cavalleri, GL, Chakravarty, MM, Chang, KD, Ching, CRK, Christoforou, A, Cichon, S, Clark, VP, Conrod, P, Coppola, G, Crespo-Facorro, B, Curran, JE, Czisch, M, Deary, IJ, de Geus, EJC, den Braber, A, Delvecchio, G, Depondt, C, de Haan, L, de Zubicaray, GI, Dima, D, Dimitrova, R, Djurovic, S, Dong, H, Donohoe, G, Duggirala, R, Dyer, TD, Ehrlich, S, Ekman, CJ, Elvsashagen, T, Emsell, L, Erk, S, Espeseth, T, Fagerness, J, Fears, S, Fedko, I, Fernandez, G, Fisher, SE, Foroud, T, Fox, PT, Francks, C, Frangou, S, Frey, EM, Frodl, T, Frouin, V, Garavan, H, Giddaluru, S, Glahn, DC, Godlewska, B, Goldstein, RZ, Gollub, RL, Grabe, HJ, Grimm, O, Gruber, O, Guadalupe, T, Gur, RE, Gur, RC, Goering, HHH, Hagenaars, S, Hajek, T, Hall, GB, Hall, J, Hardy, J, Hartman, CA, Hass, J, Hatton, SN, Haukvik, UK, Hegenscheid, K, Heinz, A, Hickie, IB, Ho, B-C, Hoehn, D, Hoekstra, PJ, Hollinshead, M, Holmes, AJ, Homuth, G, Hoogman, M, Hong, LE, Hosten, N, Hottenga, J-J, Pol, HEH, Hwang, KS, Jack, CR, Jenkinson, M, Johnston, C, Joensson, EG, Kahn, RS, Kasperaviciute, D, Kelly, S, Kim, S, Kochunov, P, Koenders, L, Kraemer, B, Kwok, JBJ, Lagopoulos, J, Laje, G, Landen, M, Landman, BA, Lauriello, J, Lawrie, SM, Lee, PH, Le Hellard, S, Lemaitre, H, Leonardo, CD, Li, C-S, Liberg, B, Liewald, DC, Liu, X, Lopez, LM, Loth, E, Lourdusamy, A, Luciano, M, Macciardi, F, Machielsen, MWJ, MacQueen, GM, Malt, UF, Mandl, R, Manoach, DS, Martinot, J-L, Matarin, M, Mather, KA, Mattheisen, M, Mattingsdal, M, Meyer-Lindenberg, A, McDonald, C, McIntosh, AM, McMahon, FJ, McMahon, KL, Meisenzahl, E, Melle, I, Milaneschi, Y, Mohnke, S, Montgomery, GW, Morris, DW, Moses, EK, Mueller, BA, Munoz Maniega, S, Muehleisen, TW, Mueller-Myhsok, B, Mwangi, B, Nauck, M, Nho, K, Nichols, TE, Nilsson, L-G, Nugent, AC, Nyberg, L, Olvera, RL, Oosterlaan, J, Ophoff, RA, Pandolfo, M, Papalampropoulou-Tsiridou, M, Papmeyer, M, Paus, T, Pausova, Z, Pearlson, GD, Penninx, BW, Peterson, CP, Pfennig, A, Phillips, M, Pike, GB, Poline, J-B, Potkin, SG, Puetz, B, Ramasamy, A, Rasmussen, J, Rietschel, M, Rijpkema, M, Risacher, SL, Roffman, JL, Roiz-Santianez, R, Romanczuk-Seiferth, N, Rose, EJ, Royle, NA, Rujescu, D, Ryten, M, Sachdev, PS, Salami, A, Satterthwaite, TD, Savitz, J, Saykin, AJ, Scanlon, C, Schmaal, L, Schnack, HG, Schork, AJ, Schulz, SC, Schuer, R, Seidman, L, Shen, L, Shoemaker, JM, Simmons, A, Sisodiya, SM, Smith, C, Smoller, JW, Soares, JC, Sponheim, SR, Sprooten, E, Starr, JM, Steen, VM, Strakowski, S, Strike, L, Sussmann, J, Saemann, PG, Teumer, A, Toga, AW, Tordesillas-Gutierrez, D, Trabzuni, D, Trost, S, Turner, J, Van den Heuvel, M, van der Wee, NJ, van Eijk, K, van Erp, TGM, van Haren, NEM, van 't Ent, D, van Tol, M-J, Hernandez, MCV, Veltman, DJ, Versace, A, Voelzke, H, Walker, R, Walter, H, Wang, L, Wardlaw, JM, Weale, ME, Weiner, MW, Wen, W, Westlye, LT, Whalley, HC, Whelan, CD, White, T, Winkler, AM, Wittfeld, K, Woldehawariat, G, Wolf, C, Zilles, D, Zwiers, MP, Thalamuthu, A, Schofield, PR, Freimer, NB, Lawrence, NS, Drevets, W, Thompson, PM, Stein, JL, Medland, SE, Hibar, DP, Vasquez, AA, Renteria, ME, Toro, R, Jahanshad, N, Schumann, G, Franke, B, Wright, MJ, Martin, NG, Agartz, I, Alda, M, Alhusaini, S, Almasy, L, Almeida, J, Alpert, K, Andreasen, NC, Andreassen, OA, Apostolova, LG, Appel, K, Armstrong, NJ, Aribisala, B, Bastin, ME, Bauer, M, Bearden, CE, Bergmann, O, Binder, EB, Blangero, J, Bockholt, HJ, Boen, E, Bois, C, Boomsma, DI, Booth, T, Bowman, IJ, Bralten, J, Brouwer, RM, Brunner, HG, Brohawn, DG, Buckner, RL, Buitelaar, J, Bulayeva, K, Bustillo, JR, Calhoun, VD, Cannon, DM, Cantor, RM, Carless, MA, Caseras, X, Cavalleri, GL, Chakravarty, MM, Chang, KD, Ching, CRK, Christoforou, A, Cichon, S, Clark, VP, Conrod, P, Coppola, G, Crespo-Facorro, B, Curran, JE, Czisch, M, Deary, IJ, de Geus, EJC, den Braber, A, Delvecchio, G, Depondt, C, de Haan, L, de Zubicaray, GI, Dima, D, Dimitrova, R, Djurovic, S, Dong, H, Donohoe, G, Duggirala, R, Dyer, TD, Ehrlich, S, Ekman, CJ, Elvsashagen, T, Emsell, L, Erk, S, Espeseth, T, Fagerness, J, Fears, S, Fedko, I, Fernandez, G, Fisher, SE, Foroud, T, Fox, PT, Francks, C, Frangou, S, Frey, EM, Frodl, T, Frouin, V, Garavan, H, Giddaluru, S, Glahn, DC, Godlewska, B, Goldstein, RZ, Gollub, RL, Grabe, HJ, Grimm, O, Gruber, O, Guadalupe, T, Gur, RE, Gur, RC, Goering, HHH, Hagenaars, S, Hajek, T, Hall, GB, Hall, J, Hardy, J, Hartman, CA, Hass, J, Hatton, SN, Haukvik, UK, Hegenscheid, K, Heinz, A, Hickie, IB, Ho, B-C, Hoehn, D, Hoekstra, PJ, Hollinshead, M, Holmes, AJ, Homuth, G, Hoogman, M, Hong, LE, Hosten, N, Hottenga, J-J, Pol, HEH, Hwang, KS, Jack, CR, Jenkinson, M, Johnston, C, Joensson, EG, Kahn, RS, Kasperaviciute, D, Kelly, S, Kim, S, Kochunov, P, Koenders, L, Kraemer, B, Kwok, JBJ, Lagopoulos, J, Laje, G, Landen, M, Landman, BA, Lauriello, J, Lawrie, SM, Lee, PH, Le Hellard, S, Lemaitre, H, Leonardo, CD, Li, C-S, Liberg, B, Liewald, DC, Liu, X, Lopez, LM, Loth, E, Lourdusamy, A, Luciano, M, Macciardi, F, Machielsen, MWJ, MacQueen, GM, Malt, UF, Mandl, R, Manoach, DS, Martinot, J-L, Matarin, M, Mather, KA, Mattheisen, M, Mattingsdal, M, Meyer-Lindenberg, A, McDonald, C, McIntosh, AM, McMahon, FJ, McMahon, KL, Meisenzahl, E, Melle, I, Milaneschi, Y, Mohnke, S, Montgomery, GW, Morris, DW, Moses, EK, Mueller, BA, Munoz Maniega, S, Muehleisen, TW, Mueller-Myhsok, B, Mwangi, B, Nauck, M, Nho, K, Nichols, TE, Nilsson, L-G, Nugent, AC, Nyberg, L, Olvera, RL, Oosterlaan, J, Ophoff, RA, Pandolfo, M, Papalampropoulou-Tsiridou, M, Papmeyer, M, Paus, T, Pausova, Z, Pearlson, GD, Penninx, BW, Peterson, CP, Pfennig, A, Phillips, M, Pike, GB, Poline, J-B, Potkin, SG, Puetz, B, Ramasamy, A, Rasmussen, J, Rietschel, M, Rijpkema, M, Risacher, SL, Roffman, JL, Roiz-Santianez, R, Romanczuk-Seiferth, N, Rose, EJ, Royle, NA, Rujescu, D, Ryten, M, Sachdev, PS, Salami, A, Satterthwaite, TD, Savitz, J, Saykin, AJ, Scanlon, C, Schmaal, L, Schnack, HG, Schork, AJ, Schulz, SC, Schuer, R, Seidman, L, Shen, L, Shoemaker, JM, Simmons, A, Sisodiya, SM, Smith, C, Smoller, JW, Soares, JC, Sponheim, SR, Sprooten, E, Starr, JM, Steen, VM, Strakowski, S, Strike, L, Sussmann, J, Saemann, PG, Teumer, A, Toga, AW, Tordesillas-Gutierrez, D, Trabzuni, D, Trost, S, Turner, J, Van den Heuvel, M, van der Wee, NJ, van Eijk, K, van Erp, TGM, van Haren, NEM, van 't Ent, D, van Tol, M-J, Hernandez, MCV, Veltman, DJ, Versace, A, Voelzke, H, Walker, R, Walter, H, Wang, L, Wardlaw, JM, Weale, ME, Weiner, MW, Wen, W, Westlye, LT, Whalley, HC, Whelan, CD, White, T, Winkler, AM, Wittfeld, K, Woldehawariat, G, Wolf, C, Zilles, D, Zwiers, MP, Thalamuthu, A, Schofield, PR, Freimer, NB, Lawrence, NS, and Drevets, W

Abstract

The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way.

Published
2014

36. The ENIGMA Consortium: Large-scale collaborative analyses of neuroimaging and genetic data

Author

Thompson, P., Stein, J., Medland, S., Hibar, D., Vasquez, A., Renteria, M., Toro, R., Jahanshad, N., Schumann, G., Franke, B., Wright, M., Martin, N., Agartz, I., Alda, M., Alhusaini, S., Almasy, L., Almeida, J., Alpert, K., Andreasen, N., Andreassen, O., Apostolova, L., Appel, K., Armstrong, N., Aribisala, B., Bastin, M., Bauer, M., Bearden, C., Bergmann, O., Binder, E., Blangero, J., Bockholt, H., Boen, E., Bois, C., Boomsma, D., Booth, T., Bowman, I., Bralten, J., Brouwer, R., Brunner, H., Brohawn, D., Buckner, R., Buitelaar, J., Bulayeva, K., Bustillo, J., Calhoun, V., Cannon, D., Cantor, R., Carless, M., Caseras, X., Cavalleri, G., Chakravarty, M., Chang, K., Ching, C., Christoforou, A., Cichon, S., Clark, V., Conrod, P., Coppola, G., Crespo-Facorro, B., Curran, J., Czisch, M., Deary, I., de Geus, E., den Braber, A., Delvecchio, G., Depondt, C., de Haan, L., de Zubicaray, G., Dima, D., Dimitrova, R., Djurovic, S., Dong, H., Donohoe, G., Duggirala, R., Dyer, T., Ehrlich, S., Ekman, C., Elvsashagen, T., Emsell, L., Erk, S., Espeseth, T., Fagerness, J., Fears, S., Fedko, I., Fernandez, G., Fisher, S., Foroud, T., Fox, P., Francks, C., Frangou, S., Frey, E., Frodl, T., Frouin, V., Garavan, H., Giddaluru, S., Glahn, D., Godlewska, B., Goldstein, R., Gollub, R., Grabe, H., Grimm, O., Gruber, O., Guadalupe, T., Gur, R., Goering, H., Hagenaars, S., Hajek, T., Hall, G., Hall, J., Hardy, J., Hartman, C., Hass, J., Hatton, S., Haukvik, U., Hegenscheid, K., Heinz, A., Hickie, I., Ho, B., Hoehn, D., Hoekstra, P., Hollinshead, M., Holmes, A., Homuth, G., Hoogman, M., Hong, L., Hosten, N., Hottenga, J., Pol, H., Hwang, K., Jack, C., Jenkinson, M., Johnston, C., Joensson, E., Kahn, R., Kasperaviciute, D., Kelly, S., Kim, S., Kochunov, P., Koenders, L., Kraemer, B., Kwok, J., Lagopoulos, J., Laje, G., Landen, M., Landman, B., Lauriello, J., Lawrie, S., Lee, P., Le Hellard, S., Lemaitre, H., Leonardo, C., Li, C., Liberg, B., Liewald, D., Liu, X., Lopez, L., Loth, E., Lourdusamy, A., Luciano, M., Macciardi, F., Machielsen, M., MacQueen, G., Malt, U., Mandl, R., Manoach, D., Martinot, J., Matarin, M., Mather, K., Mattheisen, M., Mattingsdal, M., Meyer-Lindenberg, A., McDonald, C., McIntosh, A., McMahon, F., McMahon, K., Meisenzahl, E., Melle, I., Milaneschi, Y., Mohnke, S., Montgomery, G., Morris, D., Moses, Eric, Mueller, B., Munoz Maniega, S., Muehleisen, T., Mueller-Myhsok, B., Mwangi, B., Nauck, M., Nho, K., Nichols, T., Nilsson, L., Nugent, A., Nyberg, L., Olvera, R., Oosterlaan, J., Ophoff, R., Pandolfo, M., Papalampropoulou-Tsiridou, M., Papmeyer, M., Paus, T., Pausova, Z., Pearlson, G., Penninx, B., Peterson, C., Pfennig, A., Phillips, M., Pike, G., Poline, J., Potkin, S., Puetz, B., Ramasamy, A., Rasmussen, J., Rietschel, M., Rijpkema, M., Risacher, S., Roffman, J., Roiz-Santianez, R., Romanczuk-Seiferth, N., Rose, E., Royle, N., Rujescu, D., Ryten, M., Sachdev, P., Salami, A., Satterthwaite, T., Savitz, J., Saykin, A., Scanlon, C., Schmaal, L., Schnack, H., Schork, A., Schulz, S., Schuer, R., Seidman, L., Shen, L., Shoemaker, J., Simmons, A., Sisodiya, S., Smith, C., Smoller, J., Soares, J., Sponheim, S., Sprooten, E., Starr, J., Steen, V., Strakowski, S., Strike, L., Sussmann, J., Saemann, P., Teumer, A., Toga, A., Tordesillas-Gutierrez, D., Trabzuni, D., Trost, S., Turner, J., Van den Heuvel, M., van der Wee, N., van Eijk, K., van Erp, T., van Haren, N., van 't Ent, D., van Tol, M., Hernandez, M., Veltman, D., Versace, A., Voelzke, H., Walker, R., Walter, H., Wang, L., Wardlaw, J., Weale, M., Weiner, M., Wen, W., Westlye, L., Whalley, H., Whelan, C., White, T., Winkler, A., Wittfeld, K., Woldehawariat, G., Wolf, C., Zilles, D., Zwiers, M., Thalamuthu, A., Schofield, P., Freimer, N., Lawrence, N., Drevets, W., Thompson, P., Stein, J., Medland, S., Hibar, D., Vasquez, A., Renteria, M., Toro, R., Jahanshad, N., Schumann, G., Franke, B., Wright, M., Martin, N., Agartz, I., Alda, M., Alhusaini, S., Almasy, L., Almeida, J., Alpert, K., Andreasen, N., Andreassen, O., Apostolova, L., Appel, K., Armstrong, N., Aribisala, B., Bastin, M., Bauer, M., Bearden, C., Bergmann, O., Binder, E., Blangero, J., Bockholt, H., Boen, E., Bois, C., Boomsma, D., Booth, T., Bowman, I., Bralten, J., Brouwer, R., Brunner, H., Brohawn, D., Buckner, R., Buitelaar, J., Bulayeva, K., Bustillo, J., Calhoun, V., Cannon, D., Cantor, R., Carless, M., Caseras, X., Cavalleri, G., Chakravarty, M., Chang, K., Ching, C., Christoforou, A., Cichon, S., Clark, V., Conrod, P., Coppola, G., Crespo-Facorro, B., Curran, J., Czisch, M., Deary, I., de Geus, E., den Braber, A., Delvecchio, G., Depondt, C., de Haan, L., de Zubicaray, G., Dima, D., Dimitrova, R., Djurovic, S., Dong, H., Donohoe, G., Duggirala, R., Dyer, T., Ehrlich, S., Ekman, C., Elvsashagen, T., Emsell, L., Erk, S., Espeseth, T., Fagerness, J., Fears, S., Fedko, I., Fernandez, G., Fisher, S., Foroud, T., Fox, P., Francks, C., Frangou, S., Frey, E., Frodl, T., Frouin, V., Garavan, H., Giddaluru, S., Glahn, D., Godlewska, B., Goldstein, R., Gollub, R., Grabe, H., Grimm, O., Gruber, O., Guadalupe, T., Gur, R., Goering, H., Hagenaars, S., Hajek, T., Hall, G., Hall, J., Hardy, J., Hartman, C., Hass, J., Hatton, S., Haukvik, U., Hegenscheid, K., Heinz, A., Hickie, I., Ho, B., Hoehn, D., Hoekstra, P., Hollinshead, M., Holmes, A., Homuth, G., Hoogman, M., Hong, L., Hosten, N., Hottenga, J., Pol, H., Hwang, K., Jack, C., Jenkinson, M., Johnston, C., Joensson, E., Kahn, R., Kasperaviciute, D., Kelly, S., Kim, S., Kochunov, P., Koenders, L., Kraemer, B., Kwok, J., Lagopoulos, J., Laje, G., Landen, M., Landman, B., Lauriello, J., Lawrie, S., Lee, P., Le Hellard, S., Lemaitre, H., Leonardo, C., Li, C., Liberg, B., Liewald, D., Liu, X., Lopez, L., Loth, E., Lourdusamy, A., Luciano, M., Macciardi, F., Machielsen, M., MacQueen, G., Malt, U., Mandl, R., Manoach, D., Martinot, J., Matarin, M., Mather, K., Mattheisen, M., Mattingsdal, M., Meyer-Lindenberg, A., McDonald, C., McIntosh, A., McMahon, F., McMahon, K., Meisenzahl, E., Melle, I., Milaneschi, Y., Mohnke, S., Montgomery, G., Morris, D., Moses, Eric, Mueller, B., Munoz Maniega, S., Muehleisen, T., Mueller-Myhsok, B., Mwangi, B., Nauck, M., Nho, K., Nichols, T., Nilsson, L., Nugent, A., Nyberg, L., Olvera, R., Oosterlaan, J., Ophoff, R., Pandolfo, M., Papalampropoulou-Tsiridou, M., Papmeyer, M., Paus, T., Pausova, Z., Pearlson, G., Penninx, B., Peterson, C., Pfennig, A., Phillips, M., Pike, G., Poline, J., Potkin, S., Puetz, B., Ramasamy, A., Rasmussen, J., Rietschel, M., Rijpkema, M., Risacher, S., Roffman, J., Roiz-Santianez, R., Romanczuk-Seiferth, N., Rose, E., Royle, N., Rujescu, D., Ryten, M., Sachdev, P., Salami, A., Satterthwaite, T., Savitz, J., Saykin, A., Scanlon, C., Schmaal, L., Schnack, H., Schork, A., Schulz, S., Schuer, R., Seidman, L., Shen, L., Shoemaker, J., Simmons, A., Sisodiya, S., Smith, C., Smoller, J., Soares, J., Sponheim, S., Sprooten, E., Starr, J., Steen, V., Strakowski, S., Strike, L., Sussmann, J., Saemann, P., Teumer, A., Toga, A., Tordesillas-Gutierrez, D., Trabzuni, D., Trost, S., Turner, J., Van den Heuvel, M., van der Wee, N., van Eijk, K., van Erp, T., van Haren, N., van 't Ent, D., van Tol, M., Hernandez, M., Veltman, D., Versace, A., Voelzke, H., Walker, R., Walter, H., Wang, L., Wardlaw, J., Weale, M., Weiner, M., Wen, W., Westlye, L., Whalley, H., Whelan, C., White, T., Winkler, A., Wittfeld, K., Woldehawariat, G., Wolf, C., Zilles, D., Zwiers, M., Thalamuthu, A., Schofield, P., Freimer, N., Lawrence, N., and Drevets, W.

Abstract

The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way. © 2014 The Author(s).

Published
2014

37. Payload development and launch of a stratosphere balloon mission

Author

Altmann, A., primary, Birkner, W., additional, Hackl, F. X., additional, Hanner, C., additional, Liebhart, P., additional, Metschl, S., additional, Weck, F., additional, Farmbauer, M., additional, Heiss, M., additional, Cuno, H-H, additional, Fuhrmann, T., additional, Mandl, R., additional, Mottok, J., additional, and Niemetz, M., additional

Published
2014
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38. Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group

Author

Kelly, S, Jahanshad, N, Zalesky, A, Kochunov, P, Agartz, I, Alloza, C, Andreassen, O A, Arango, C, Banaj, N, Bouix, S, Bousman, C A, Brouwer, R M, Bruggemann, J, Bustillo, J, Cahn, W, Calhoun, V, Cannon, D, Carr, V, Catts, S, Chen, J, Chen, J-x, Chen, X, Chiapponi, C, Cho, Kl K, Ciullo, V, Corvin, A S, Crespo-Facorro, B, Cropley, V, De Rossi, P, Diaz-Caneja, C M, Dickie, E W, Ehrlich, S, Fan, F-m, Faskowitz, J, Fatouros-Bergman, H, Flyckt, L, Ford, J M, Fouche, J-P, Fukunaga, M, Gill, M, Glahn, D C, Gollub, R, Goudzwaard, E D, Guo, H, Gur, R E, Gur, R C, Gurholt, T P, Hashimoto, R, Hatton, S N, Henskens, F A, Hibar, D P, Hickie, I B, Hong, L E, Horacek, J, Howells, F M, Hulshoff Pol, H E, Hyde, C L, Isaev, D, Jablensky, A, Jansen, P R, Janssen, J, Jönsson, E G, Jung, L A, Kahn, R S, Kikinis, Z, Liu, K, Klauser, P, Knöchel, C, Kubicki, M, Lagopoulos, J, Langen, C, Lawrie, S, Lenroot, R K, Lim, K O, Lopez-Jaramillo, C, Lyall, A, Magnotta, V, Mandl, R C W, Mathalon, D H, McCarley, R W, McCarthy-Jones, S, McDonald, C, McEwen, S, McIntosh, A, Melicher, T, Mesholam-Gately, R I, Michie, P T, Mowry, B, Mueller, B A, Newell, D T, O'Donnell, P, Oertel-Knöchel, V, Oestreich, L, Paciga, S A, Pantelis, C, Pasternak, O, Pearlson, G, Pellicano, G R, Pereira, A, Pineda Zapata, J, Piras, F, Potkin, S G, Preda, A, Rasser, P E, Roalf, D R, Roiz, R, Roos, A, Rotenberg, D, Satterthwaite, T D, Savadjiev, P, Schall, U, Scott, R J, Seal, M L, Seidman, L J, Shannon Weickert, C, Whelan, C D, Shenton, M E, Kwon, J S, Spalletta, G, Spaniel, F, Sprooten, E, Stäblein, M, Stein, D J, Sundram, S, Tan, Y, Tan, S, Tang, S, Temmingh, H S, Westlye, L T, Tønnesen, S, Tordesillas-Gutierrez, D, Doan, N T, Vaidya, J, van Haren, N E M, Vargas, C D, Vecchio, D, Velakoulis, D, Voineskos, A, Voyvodic, J Q, Wang, Z, Wan, P, Wei, D, Weickert, T W, Whalley, H, White, T, Whitford, T J, Wojcik, J D, Xiang, H, Xie, Z, Yamamori, H, Yang, F, Yao, N, Zhang, G, Zhao, J, van Erp, T G M, Turner, J, Thompson, P M, and Donohoe, G

Abstract

The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly understood, and reported disease effects on the brain vary widely between studies. In an effort to identify commonalities across studies, we perform what we believe is the first ever large-scale coordinated study of WM microstructural differences in schizophrenia. Our analysis consisted of 2359 healthy controls and 1963 schizophrenia patients from 29 independent international studies; we harmonized the processing and statistical analyses of diffusion tensor imaging (DTI) data across sites and meta-analyzed effects across studies. Significant reductions in fractional anisotropy (FA) in schizophrenia patients were widespread, and detected in 20 of 25 regions of interest within a WM skeleton representing all major WM fasciculi. Effect sizes varied by region, peaking at (d=0.42) for the entire WM skeleton, driven more by peripheral areas as opposed to the core WM where regions of interest were defined. The anterior corona radiata (d=0.40) and corpus callosum (d=0.39), specifically its body (d=0.39) and genu (d=0.37), showed greatest effects. Significant decreases, to lesser degrees, were observed in almost all regions analyzed. Larger effect sizes were observed for FA than diffusivity measures; significantly higher mean and radial diffusivity was observed for schizophrenia patients compared with controls. No significant effects of age at onset of schizophrenia or medication dosage were detected. As the largest coordinated analysis of WM differences in a psychiatric disorder to date, the present study provides a robust profile of widespread WM abnormalities in schizophrenia patients worldwide. Interactive three-dimensional visualization of the results is available at www.enigma-viewer.org.

Published
2018
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39. Identification of common variants associated with human hippocampal and intracranial volumes

Author

Stein, J., Medland, S., Vasquez, A., Hibar, D., Senstad, R., Winkler, A., Toro, R., Appel, K., Bartecek, R., Bergmann, O., Bernard, M., Brown, A., Cannon, D., Chakravarty, M., Christoforou, A., Domin, M., Grimm, O., Hollinshead, M., Holmes, A., Homuth, G., Hottenga, J., Langan, C., Lopez, L., Hansell, N., Hwang, K., Kim, S., Laje, G., Lee, P., Liu, X., Loth, E., Lourdusamy, A., Mattingsdal, M., Mohnke, S., Maniega, S., Nho, K., Nugent, A., O'Brien, C., Papmeyer, M., Putz, B., Ramasamy, A., Rasmussen, J., Rijpkema, M., Risacher, S., Roddey, J., Rose, E., Ryten, M., Shen, L., Sprooten, E., Strengman, E., Teumer, A., Trabzuni, D., Turner, J., van Eijk, K., van Erp, T., van Tol, M., Wittfeld, K., Wolf, C., Woudstra, S., Aleman, A., Alhusaini, S., Almasy, L., Binder, E., Brohawn, D., Cantor, R., Carless, M., Corvin, A., Czisch, M., Curran, J., Davies, G., de Almeida, M., Delanty, N., Depondt, C., Duggirala, R., Dyer, T., Erk, S., Fagerness, J., Fox, P., Freimer, N., Gill, M., Goering, H., Hagler, D., Hoehn, D., Holsboer, F., Hoogman, M., Hosten, N., Jahanshad, N., Johnson, M., Kasperaviciute, D., Kent, J., Kochunov, P., Lancaster, J., Lawrie, S., Liewald, D., Mandl, R., Matarin, M., Mattheisen, M., Meisenzahl, E., Melle, I., Moses, Eric, Muehleisen, T., Nauck, M., Noethen, M., Olvera, R., Pandolfo, M., Pike, G., Puls, R., Reinvang, I., Renteria, M., Rietschel, M., Roffman, J., Royle, N., Rujescu, D., Savitz, J., Schnack, H., Schnell, K., Seiferth, N., Smith, C., Steen, V., Hernandez, M., Van den Heuvel, M., van der Wee, N., Van Haren, N., Veltman, J., Voelzke, H., Walker, R., Westlye, L., Whelan, C., Agartz, I., Boomsma, D., Cavalleri, G., Dale, A., Djurovic, S., Drevets, W., Hagoort, P., Hall, J., Heinz, A., Jack, C., Foroud, T., Le Hellard, S., Macciardi, F., Montgomery, G., Poline, J., Porteous, D., Sisodiya, S., Starr, J., Sussmann, J., Toga, A., Veltman, D., Walter, H., Weiner, M., Bis, J., Ikram, M., Smith, A., Gudnason, V., Tzourio, C., Vernooij, M., Launer, L., DeCarli, C., Seshadri, S., Andreassen, O., Apostolova, L., Bastin, M., Blangero, J., Brunner, H., Buckner, R., Cichon, S., Coppola, G., de Zubicaray, G., Deary, I., Donohoe, G., de Geus, E., Espeseth, T., Fernandez, G., Glahn, D., Grabe, H., Hardy, J., Pol, H., Jenkinson, M., Kahn, R., McDonald, C., McIntosh, A., McMahon, F., McMahon, K., Meyer-Lindenberg, A., Morris, D., Mueller-Myhsok, B., Nichols, T., Ophoff, R., Paus, T., Pausova, Z., Penninx, B., Potkin, S., Saemann, P., Saykin, A., Schumann, G., Smoller, J., Wardlaw, J., Weale, M., Martin, N., Franke, B., Wright, M., Thompson, P., Stein, J., Medland, S., Vasquez, A., Hibar, D., Senstad, R., Winkler, A., Toro, R., Appel, K., Bartecek, R., Bergmann, O., Bernard, M., Brown, A., Cannon, D., Chakravarty, M., Christoforou, A., Domin, M., Grimm, O., Hollinshead, M., Holmes, A., Homuth, G., Hottenga, J., Langan, C., Lopez, L., Hansell, N., Hwang, K., Kim, S., Laje, G., Lee, P., Liu, X., Loth, E., Lourdusamy, A., Mattingsdal, M., Mohnke, S., Maniega, S., Nho, K., Nugent, A., O'Brien, C., Papmeyer, M., Putz, B., Ramasamy, A., Rasmussen, J., Rijpkema, M., Risacher, S., Roddey, J., Rose, E., Ryten, M., Shen, L., Sprooten, E., Strengman, E., Teumer, A., Trabzuni, D., Turner, J., van Eijk, K., van Erp, T., van Tol, M., Wittfeld, K., Wolf, C., Woudstra, S., Aleman, A., Alhusaini, S., Almasy, L., Binder, E., Brohawn, D., Cantor, R., Carless, M., Corvin, A., Czisch, M., Curran, J., Davies, G., de Almeida, M., Delanty, N., Depondt, C., Duggirala, R., Dyer, T., Erk, S., Fagerness, J., Fox, P., Freimer, N., Gill, M., Goering, H., Hagler, D., Hoehn, D., Holsboer, F., Hoogman, M., Hosten, N., Jahanshad, N., Johnson, M., Kasperaviciute, D., Kent, J., Kochunov, P., Lancaster, J., Lawrie, S., Liewald, D., Mandl, R., Matarin, M., Mattheisen, M., Meisenzahl, E., Melle, I., Moses, Eric, Muehleisen, T., Nauck, M., Noethen, M., Olvera, R., Pandolfo, M., Pike, G., Puls, R., Reinvang, I., Renteria, M., Rietschel, M., Roffman, J., Royle, N., Rujescu, D., Savitz, J., Schnack, H., Schnell, K., Seiferth, N., Smith, C., Steen, V., Hernandez, M., Van den Heuvel, M., van der Wee, N., Van Haren, N., Veltman, J., Voelzke, H., Walker, R., Westlye, L., Whelan, C., Agartz, I., Boomsma, D., Cavalleri, G., Dale, A., Djurovic, S., Drevets, W., Hagoort, P., Hall, J., Heinz, A., Jack, C., Foroud, T., Le Hellard, S., Macciardi, F., Montgomery, G., Poline, J., Porteous, D., Sisodiya, S., Starr, J., Sussmann, J., Toga, A., Veltman, D., Walter, H., Weiner, M., Bis, J., Ikram, M., Smith, A., Gudnason, V., Tzourio, C., Vernooij, M., Launer, L., DeCarli, C., Seshadri, S., Andreassen, O., Apostolova, L., Bastin, M., Blangero, J., Brunner, H., Buckner, R., Cichon, S., Coppola, G., de Zubicaray, G., Deary, I., Donohoe, G., de Geus, E., Espeseth, T., Fernandez, G., Glahn, D., Grabe, H., Hardy, J., Pol, H., Jenkinson, M., Kahn, R., McDonald, C., McIntosh, A., McMahon, F., McMahon, K., Meyer-Lindenberg, A., Morris, D., Mueller-Myhsok, B., Nichols, T., Ophoff, R., Paus, T., Pausova, Z., Penninx, B., Potkin, S., Saemann, P., Saykin, A., Schumann, G., Smoller, J., Wardlaw, J., Weale, M., Martin, N., Franke, B., Wright, M., and Thompson, P.

Abstract

Identifying genetic variants influencing human brain structures may reveal new biological mechanisms underlying cognition and neuropsychiatric illness. The volume of the hippocampus is a biomarker of incipient Alzheimer's disease and is reduced in schizophrenia, major depression and mesial temporal lobe epilepsy. Whereas many brain imaging phenotypes are highly heritable, identifying and replicating genetic influences has been difficult, as small effects and the high costs of magnetic resonance imaging (MRI) have led to underpowered studies. Here we report genome-wide association meta-analyses and replication for mean bilateral hippocampal, total brain and intracranial volumes from a large multinational consortium. The intergenic variant rs7294919 was associated with hippocampal volume (12q24.22; N = 21,151; P = 6.70 × 10 -16) and the expression levels of the positional candidate gene TESC in brain tissue. Additionally, rs10784502, located within HMGA2, was associated with intracranial volume (12q14.3; N = 15,782; P = 1.12 × 10 -12). We also identified a suggestive association with total brain volume at rs10494373 within DDR2 (1q23.3; N = 6,500; P = 5.81 × 10 -7). © 2012 Nature America, Inc. All rights reserved.

Published
2012

49. Saccade dysmetria indicates attenuated visual exploration in autism spectrum disorder

Author

Bast, N., Mason, L., Freitag, C. M., Smith, T., Portugal, A. M., Poustka, L., Banaschewski, T., Johnson, M., Ahmad, J., Ambrosino, S., Auyeung, B., Baron-Cohen, S., Baumeister, S., Beckmann, C. F., Bolte, S., Bourgeron, T., Bours, C., Brammer, M., Brandeis, D., Brogna, C., Bruijn, Y. d., Buitelaar, J. K., Chakrabarti, B., Charman, T., Cornelissen, I., Crawley, D., Dell'Acqua, F., Dumas, G., Durston, S., Ecker, C., Faulkner, J., Frouin, V., Garces, P., Goyard, D., Ham, L., Hayward, H., Hipp, J., Holt, R., Jones, E. J. H., Kundu, P., Lai, M. -C., D'Ardhuy, X. L., Lombardo, M. V., Loth, E., Lythgoe, D. J., Mandl, R., Marquand, A., Mennes, M., Meyer-Lindenberg, A., Moessnang, C., Murphy, D. G. M., Oakley, B., O'Dwyer, L., Oldehinkel, M., Oranje, B., Pandina, G., Persico, A., Ruggeri, B., Ruigrok, A., Sabet, J., Sacco, R., San Jose Caceres, A., Simonoff, E., Spooren, W., Tillmann, J., Toro, R., Tost, H., Waldman, J., Williams, S. C. R., Wooldridge, C., Zwiers, M. P., and The EU-AIMS LEAP Group

Subjects
Male, medicine.medical_specialty, cerebellum, Cerebellar Ataxia, Eye Movements, genetic structures, Autism Spectrum Disorder, Audiology, eye tracking, brainstem, 03 medical and health sciences, 0302 clinical medicine, ddc:150, Dysmetria, biomarker, Eye tracking, locus coeruleus, pupillometry, visual attention, Saccades, Developmental and Educational Psychology, medicine, Humans, Attention, 0501 psychology and cognitive sciences, ddc:610, 05 social sciences, Infant, Newborn, Cognition, Fixation (psychology), medicine.disease, Motor coordination, Psychiatry and Mental health, Autism spectrum disorder, Pediatrics, Perinatology and Child Health, Saccade, Female, Psychology, 030217 neurology & neurosurgery, Pupillometry, Neurotypical, 050104 developmental & child psychology
Abstract

Background: Visual exploration in autism spectrum disorder (ASD) is characterized by attenuated social attention. The underlying oculomotor function during visual exploration is understudied, whereas oculomotor function during restricted viewing suggested saccade dysmetria in ASD by altered pontocerebellar motor modulation. Methods: Oculomotor function was recorded using remote eye tracking in 142 ASD participants and 142 matched neurotypical controls during free viewing of naturalistic videos with and without human content. The sample was heterogenous concerning age (6–30 years), cognitive ability (60–140 IQ), and male/female ratio (3:1). Oculomotor function was defined as saccade, fixation, and pupil‐dilation features that were compared between groups in linear mixed models. Oculomotor function was investigated as ASD classifier and features were correlated with clinical measures. Results: We observed decreased saccade duration (∆M = −0.50, CI [−0.21, −0.78]) and amplitude (∆M = −0.42, CI [−0.12, −0.72]), which was independent of human video content. We observed null findings concerning fixation and pupil‐dilation features (POWER = .81). Oculomotor function is a valid ASD classifier comparable to social attention concerning discriminative power. Within ASD, saccade features correlated with measures of restricted and repetitive behavior. Conclusions: We conclude saccade dysmetria as ASD oculomotor phenotype relevant to visual exploration. Decreased saccade amplitude and duration indicate spatially clustered fixations that attenuate visual exploration and emphasize endogenous over exogenous attention. We propose altered pontocerebellar motor modulation as underlying mechanism that contributes to atypical (oculo‐)motor coordination and attention function in ASD.

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50. A Cylindrical, Open‐Top Chamber for the Exposure of Plants to Air Pollutants in the Field

Author

Mandl, R. H., Weinstein, L. H., McCune, D. C., and Keveny, Monica

Abstract

Much of the information on the effects of air pollutants on plant life has been derived from studies with controlled‐environment, greenhouse, and field fumigation equipment. Each of these is important for the gaining of conditional information on the response of plants to air pollutants, but none of them can simulate ambient environmental conditions. Portable and fixed field fumigation chambers have perhaps come the closest to providing the ambient milieu, but the usual closed design alters normal conditions of light intensity and quality, temperature and humidity fluctuations, precipitation, and free access of insects and plant pathogens. A simple, relatively inexpensive, and light‐weight open‐top chamber of modular design has been built and tested. Each module is 1.22 m (4 feet) high and 2.74 m (9 feet) in diameter, and can be stacked vertically in combinations of 1, 2, or 3 modules. The modules are fabricated from corrugated fiberglass panels attached to aluminum hoops and the air‐delivery plenum from lay‐flat polyethylene tubing. A mobile air filter and blower assembly provides air that has passed through a dust filter and an activated‐charcoal filter. An open plastic mesh placed across the top of the chamber reduces the influence of wind on the air distribution system, but it does not impede the entrance of precipitation or of insects. The chamber was tested in several ways: (i) efficiency of the chamber and filter‐blower assembly for exclusion of ambient oxidants was tested by monitoring the atmosphere and by growing susceptible plants in chambers with or without charcoal filters and in outside plots; (ii) distribution and concentration of an introduced pollutant within the chamber were measured by a dynamic air monitoring method; and (iii) accumulation of an introduced pollutant was studied with both plants and a static monitoring method.

Published
1973
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