7,861 results on '"Mandibular Diseases"'
Search Results
2. Predictive factors of osteoradionecrosis necessitating segmental mandibulectomy: A descriptive study
- Author
-
Tso, Theodore V, Blackwell, Keith E, and Sung, Eric C
- Subjects
Cancer ,Patient Safety ,Dental/Oral and Craniofacial Disease ,Clinical Research ,Prevention ,Humans ,Mandible ,Mandibular Diseases ,Mandibular Osteotomy ,Osteoradionecrosis ,Plastic Surgery Procedures ,Retrospective Studies ,Dentistry - Abstract
ObjectiveThe objective of this study was to assess characteristics of patients with mandibular osteoradionecrosis (ORN) of severity necessitating segmental mandibulectomy and osteocutaneous free flap reconstruction.Study designThis study is a retrospective review of patients who underwent free flap reconstruction of the mandible at the UCLA Medical Center between January 2016 and February 2020 secondary to ORN.ResultsTwenty-nine charts with detailed dental and medical records were identified. Hypertension was reported in 14 of 29 patients, diabetes in 2 of 29, osteoporosis in 2 of 29, antiresorptive use in 3 of 29, tobacco use in 15 of 29, and alcohol use in 19 of 29. Twenty-three patients initially had stage III-IV cancer. The median radiation dose was 68 Gy and median time to ORN was 5.2 years. Chemotherapy was given in 21 patients and 4 had previous mandibular surgery. Twelve of 29 patients had surgical procedures identified as the causative factor and 17 of 29 occurred spontaneously. Median decayed, missing, and filled teeth score was 17 and 17 of 29 patients had grade II-IV periodontitis. Periodontitis was present in 8 of 17 of spontaneous and 1 of 12 of surgery cases. Twenty-five of 29 cases occurred in the same oral sextant as the tumor.ConclusionSevere ORN occurred at doses >60 Gy in most cases. Location of the primary tumor was predictive of site of ORN and only molars were involved when precipitated by tooth extraction. Risk of ORN persists indefinitely.
- Published
- 2022
3. Relationship between stomatognathic alterations and idiopathic scoliosis: a systematic review with meta-analysis of observational studies
- Author
-
Francisca Gámiz-Bermúdez, Alfonso Javier Ibáñez-Vera, Esteban Obrero-Gaitán, Irene Cortés-Pérez, Noelia Zagalaz-Anula, and Rafael Lomas-Vega
- Subjects
scoliosis ,adolescent idiopathic scoliosis ,temporomandibular joint disorders ,stomatognathic diseases ,occlusal dysfunction ,malocclusion ,mandibular diseases ,Orthopedic surgery ,RD701-811 - Abstract
Purpose: The objective of this systematic review was to assess a possible relationship between stomatognathic alterations and idiopathic scoliosis (IS). Design: This study is a systematic review with meta-analysis of observational studies. Methods: The protocol of this systematic review with meta-analysis was registered in PROSPERO (CRD42022370593). A bibliographic search was carried out in the Pubmed (MEDLINE), Scopus, Web of Science and CINAHL databases using the MeSH terms ‘Scoliosis’ and ‘Stomatognathic Disease’. The odds ratio (OR) of prevalence and standardized mean difference (SMD) were used to synthesize the results. Results: Of 1592 studies located, 14 studies were selected with 3018 subjects (age: 13.9 years). IS was related to Angle’s class II (OR = 2.052, 95% CI = 1.236–3.406) and crossbite (OR = 2.234, 95% CI = 1.639–3.045). Patients with malocclusion showed a higher prevalence of IS than controls (OR = 4.633, 95% CI = 1.467–14.628), and subjects with IS showed high overjet (SMD = 0.405, 95% CI = 0.149–0.661) and greater dysfunction due to temporomandibular disorders (SMD = 1.153, 95% CI = 0.780–1.527). Conclusion: Compared with healthy controls, subjects with IS have twice the risk of suffering from occlusion disorders, present greater temporomandibular dysfunction and have a greater overjet in the incisors. Moreover, subjects with malocclusion have an IS prevalence up to four times higher. The systematic orofacial examination of patients with IS should be recommended.
- Published
- 2023
- Full Text
- View/download PDF
4. Evaluation of an Intra Auricular Device as a Treatment for Painful Temporo-Mandibular Disorders (IAD)
- Author
-
Valeria Donnarumma, Principal Investigator
- Published
- 2022
5. Assessment of Nociceptive Processing Among Patients With Temporo-mandibular Disorders
- Published
- 2022
6. Effect Of Sleep Apnea Treatment On Temporo-Mandibular Disorders
- Author
-
Anna Alessandri Bonetti, Principal Investigator
- Published
- 2021
7. Virtual Anatomical Reconstruction of Mandibular Bone Defects Using a Statistical Shape Model
- Published
- 2021
8. Pseudotumor of the Maxillary Sinus in a Child with Von Willebrand Disease
- Author
-
Martha Gutierrez Perez, Juan Lugo Machado, Natalia Barreto Nino, Luis Paredes Bastos, and David Acevedo Contreras
- Subjects
child ,hemophilic pseudotumor ,mandibular diseases ,pediatrics ,von willebrand diseases ,Otorhinolaryngology ,RF1-547 - Abstract
Introduction:Mandibular pseudotumors, also known as blood cysts, are rare complications which occur more frequently in patients with an associated bleeding disorder such as hemophilia.Case Report: We present a case of a 2-year and 6-month-old patient with a hemophilic pseudotumor associated with Von Willebrand's disease, who consulted the emergency room due to spontaneous increase in volume of the left maxillary region, with no previous relevant medical history.Conclusions:Different imaging studies were carried out to characterize the lesion, providing the necessary information for the correct approach. Due to the low prevalence of this complication, we believe it is of vital importance to understand the adequate management in this patient population.
- Published
- 2022
- Full Text
- View/download PDF
9. A Retrospective Clinical Trial Regarding Oral Rehabilitation Diagnosis Strategies Based on Stomatognathic System Pathology.
- Author
-
Lupu, Iulian Costin, Checherita, Laura Elisabeta, Antohe, Magda Ecaterina, Stamatin, Ovidiu, Teslaru, Silvia, Hamburda, Tudor, Tarevici, Eugenia Larisa, Bulancea, Bogdan Petru, Trandafirescu, Mioara, Gena Dascalu, Cristina, Cuciureanu, Magdalena, Gradinaru, Irina, Burlea, Lucian Stefan, and Jehac, Alina Elena
- Subjects
STOMATOGNATHIC system ,PATHOLOGY ,DIAGNOSIS ,FACIAL pain ,TEMPOROMANDIBULAR disorders ,OROFACIAL pain ,OLDER patients - Abstract
Introduction: Orofacial pain is a common occurrence in daily dental practice; it is frequently attributed to temporomandibular dysfunction, one of its major causes, followed by pathology of the salivary glands, without avoiding interference at the level of the pain pathways caused by complications of periodontal pathology. The main objective of this study is to identify an important cause of pain in the oral–maxillofacial territory by quantifying the changes at the salivary glandular level using stereological methods. The secondary objective of the present research is to identify the implications of periodontal changes as a consequence of salivary quantitative and qualitative changes, quantified using periodontal indices, on the balance of the temporomandibular joint, dysfunction of it being an important cause of facial pain and having a profound impact on the complex oral rehabilitation algorithm of each clinical case, a condition evaluated with the analysis of the results of the Souleroy questionnaire. Material and methods: In a retrospective study, we evaluated the clinical results obtained after applying complex rehabilitation treatment to 35 subjects, 20 women and 15 men with salivary and TMJ dysfunctions, selected between 2020 and 2021 from the Clinic of Maxillofacial Surgery, Iasi. Results and discussion: The most common symptoms of temporomandibular disorders (TMDs) that were identified through the Souleroy questionnaire were pain and different types of damage to the masticatory muscles. The most significant changes in elders are reported in the case of serous cells, which reduced their percentage volume from 46.7% to 37.4%. Conclusion: As regards stereological analysis in conjunction with histological images, there were significant changes in diameters, perimeters, and longitudinal axes in the adult patients as opposed to the elderly patients, which were also influenced by the type of pathology at this level. The scores recorded on the diagnostic Souleroy scale indicated a large number of patients with low efficiency and maximum stress levels: 20.0% in level 1, 25.7% in level 2, and 25.7% in level 3. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
10. Pseudotumor of the Maxillary Sinus in a Child with Von Willebrand Disease.
- Author
-
Gutiérrez Pérez, Martha Lucía, Lugo Machado, Juan Antonio, Barreto Niño, Natalia, Paredes Bastos, Luis Alfonso, and Acevedo Contreras, David Fernando
- Subjects
- *
MAXILLARY sinus , *VON Willebrand disease , *HOSPITAL emergency services - Abstract
Introduction: Mandibular pseudotumors, also known as blood cysts, are rare complications which occur more frequently in patients with an associated bleeding disorder such as hemophilia. Case Report: We present a case of a 2-year and 6-month-old patient with a hemophilic pseudotumor associated with Von Willebrand's disease, who consulted the emergency room due to spontaneous increase in volume of the left maxillary region, with no previous relevant medical history. Conclusions: Different imaging studies were carried out to characterize the lesion, providing the necessary information for the correct approach. Due to the low prevalence of this complication, we believe it is of vital importance to understand the adequate management in this patient population. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
11. Jaw Reconstruction With Printed Titanium and Free Tissue Transfer (JaW PrinT)
- Published
- 2019
12. Idiopathic condylar resorption in adolescents: A scoping review.
- Author
-
Nobrega MTC, Almeida FT, Friesen R, Davis C, and Major PW
- Subjects
- Humans, Adolescent, Prevalence, Temporomandibular Joint Disorders physiopathology, Temporomandibular Joint Disorders therapy, Temporomandibular Joint Disorders etiology, Mandibular Diseases, Mandibular Condyle pathology, Mandibular Condyle physiopathology, Bone Resorption physiopathology
- Abstract
Objective: Idiopathic condylar resorption (ICR), also known as progressive condylar resorption, is poorly understood, particularly in adolescent patients. Therefore, this scoping review aims to summarize the available literature on the prevalence, aetiology, pathogenesis, diagnostic process, treatment and/or any outcome regarding ICR in adolescent individuals., Methods: This scoping review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and its extension for scoping reviews (PRISMA-ScR), as well as Joanna Briggs Institute studies. The search strategy was defined adopting a core search structure for each source, and the search was performed on MEDLINE, EMBASE, Cochrane Library, Web of Science, Scopus and Google Scholar. After duplicate removal, two independent reviewers screened abstracts, followed by complete articles, to achieve the definition of included studies. Data collection was performed, and the extracted data were organized in tabular form, along with a narrative summary of main findings that aligns with the objective of this review., Results: Six observational studies were included in this review. Three studies focused on signs and symptoms, one on prevalence and signs and symptoms, one on treatment and one on disease pathogenesis., Conclusion: This scoping review revealed inadequate published research regarding prevalence, aetiology, early diagnosis, pathogenesis and treatment of ICR in adolescents., (© 2024 The Authors. Journal of Oral Rehabilitation published by John Wiley & Sons Ltd.)
- Published
- 2024
- Full Text
- View/download PDF
13. Osteonecrosis mandibular inducida por bifosfonatos en un anciano.
- Author
-
Chi Rivas, Julio César, Gutiérrez Galano, Islay Efraín, and Fuentes Texidor, Roennis
- Subjects
- *
MAXILLOFACIAL surgery , *CANCER hospitals , *INFLAMMATION , *OSTEONECROSIS , *OLDER people - Abstract
The case report of a 67 years elderly is described. He was assisted in the Maxillofacial Surgery Service of Mártires del Moncada Teaching Provincial Stomatological Clinic in Santiago de Cuba, referred from Conrado Benítez Teaching Provincial Cancer Hospital due to necrotic tissue in the inferior sector of the jaw. After the clinical and complementary exams, and also establish the presumed diagnosis of mandibular osteonecrosis induced by biphosfonates, it was decided to practice the exeresis of the necrotic bone portion, to which a histopathologic study was carried out that confirmed the existence of the disease. The postoperative evolution was satisfactory; there were not excessive inflammatory process neither dehiscence of the surgical wound. [ABSTRACT FROM AUTHOR]
- Published
- 2022
14. Collagen Sponge Functionalized with Chimeric Anti-BMP-2 Monoclonal Antibody Mediates Repair of Critical-Size Mandibular Continuity Defects in a Nonhuman Primate Model
- Author
-
Xie, Yilin, Su, Yingying, Min, Seiko, Tang, Jianxia, Goh, Bee Tin, Saigo, Leonardo, Ansari, Sahar, Moshaverinia, Alireza, Zhang, Chunmei, Wang, Jinsong, Liu, Yi, Khojasteh, Arash, Zadeh, Homayoun H, and Wang, Songlin
- Subjects
Engineering ,Biomedical Engineering ,Dental/Oral and Craniofacial Disease ,Biotechnology ,Development of treatments and therapeutic interventions ,5.2 Cellular and gene therapies ,Animals ,Antibodies ,Monoclonal ,Bone Morphogenetic Protein 2 ,Bone Regeneration ,Collagen ,Disease Models ,Animal ,Humans ,Macaca fascicularis ,Mandible ,Mandibular Diseases ,Osteogenesis ,Tissue Engineering ,Tissue Scaffolds ,Wound Healing ,Biological Sciences ,Information and Computing Sciences ,Technology - Abstract
Antibody-mediated osseous regeneration (AMOR) has been introduced by our research group as a tissue engineering approach to capture of endogenous growth factors through the application of specific monoclonal antibodies (mAbs) immobilized on a scaffold. Specifically, anti-Bone Morphogenetic Protein- (BMP-) 2 mAbs have been demonstrated to be efficacious in mediating bone repair in a number of bone defects. The present study sought to investigate the application of AMOR for repair of mandibular continuity defect in nonhuman primates. Critical-sized mandibular continuity defects were created in Macaca fascicularis locally implanted with absorbable collagen sponges (ACS) functionalized with chimeric anti-BMP-2 mAb or isotype control mAb. 2D and 3D analysis of cone beam computed tomography (CBCT) imaging demonstrated increased bone density and volume observed within mandibular continuity defects implanted with collagen scaffolds functionalized with anti-BMP-2 mAb, compared with isotype-matched control mAb. Both CBCT imaging and histologic examination demonstrated de novo bone formation that was in direct apposition to the margins of the resected bone. It is hypothesized that bone injury may be necessary for AMOR. This is evidenced by de novo bone formation adjacent to resected bone margins, which may be the source of endogenous BMPs captured by anti-BMP-2 mAb, in turn mediating bone repair.
- Published
- 2017
15. A Retrospective Clinical Trial Regarding Oral Rehabilitation Diagnosis Strategies Based on Stomatognathic System Pathology
- Author
-
Iulian Costin Lupu, Laura Elisabeta Checherita, Magda Ecaterina Antohe, Ovidiu Stamatin, Silvia Teslaru, Tudor Hamburda, Eugenia Larisa Tarevici, Bogdan Petru Bulancea, Mioara Trandafirescu, Cristina Gena Dascalu, Magdalena Cuciureanu, Irina Gradinaru, Lucian Stefan Burlea, and Alina Elena Jehac
- Subjects
stomatognathic system ,diagnoses and examinations ,rehabilitation outcome ,periodontal diseases ,mandibular diseases ,Biology (General) ,QH301-705.5 - Abstract
Introduction: Orofacial pain is a common occurrence in daily dental practice; it is frequently attributed to temporomandibular dysfunction, one of its major causes, followed by pathology of the salivary glands, without avoiding interference at the level of the pain pathways caused by complications of periodontal pathology. The main objective of this study is to identify an important cause of pain in the oral–maxillofacial territory by quantifying the changes at the salivary glandular level using stereological methods. The secondary objective of the present research is to identify the implications of periodontal changes as a consequence of salivary quantitative and qualitative changes, quantified using periodontal indices, on the balance of the temporomandibular joint, dysfunction of it being an important cause of facial pain and having a profound impact on the complex oral rehabilitation algorithm of each clinical case, a condition evaluated with the analysis of the results of the Souleroy questionnaire. Material and methods: In a retrospective study, we evaluated the clinical results obtained after applying complex rehabilitation treatment to 35 subjects, 20 women and 15 men with salivary and TMJ dysfunctions, selected between 2020 and 2021 from the Clinic of Maxillofacial Surgery, Iasi. Results and discussion: The most common symptoms of temporomandibular disorders (TMDs) that were identified through the Souleroy questionnaire were pain and different types of damage to the masticatory muscles. The most significant changes in elders are reported in the case of serous cells, which reduced their percentage volume from 46.7% to 37.4%. Conclusion: As regards stereological analysis in conjunction with histological images, there were significant changes in diameters, perimeters, and longitudinal axes in the adult patients as opposed to the elderly patients, which were also influenced by the type of pathology at this level. The scores recorded on the diagnostic Souleroy scale indicated a large number of patients with low efficiency and maximum stress levels: 20.0% in level 1, 25.7% in level 2, and 25.7% in level 3.
- Published
- 2023
- Full Text
- View/download PDF
16. Regenerating Mandibular Bone Using rhBMP‐2: Part 1—Immediate Reconstruction of Segmental Mandibulectomies
- Author
-
Arzi, Boaz, Verstraete, Frank JM, Huey, Daniel J, Cissell, Derek D, and Athanasiou, Kyriacos A
- Subjects
Veterinary Sciences ,Agricultural ,Veterinary and Food Sciences ,Dental/Oral and Craniofacial Disease ,Musculoskeletal ,Animals ,Bone Morphogenetic Protein 2 ,Bone Plates ,Bone Regeneration ,Bone Substitutes ,Dog Diseases ,Dogs ,Humans ,Mandible ,Mandibular Diseases ,Mandibular Osteotomy ,Mandibular Reconstruction ,Prospective Studies ,Recombinant Proteins ,Plastic Surgery Procedures ,Transforming Growth Factor beta ,Veterinary sciences - Abstract
ObjectiveTo describe a surgical technique using a regenerative approach and internal fixation for immediate reconstruction of critical size bone defects after segmental mandibulectomy in dogs.Study designProspective case series.AnimalsDogs (n = 4) that had reconstruction after segmental mandibulectomy for treatment of malignant or benign tumors.MethodsUsing a combination of extraoral and intraoral approaches, a locking titanium plate was contoured to match the native mandible. After segmental mandibulectomy, the plate was secured and a compression resistant matrix (CRM) infused with rhBMP-2, implanted in the defect. The implant was then covered with a soft tissue envelope followed by intraoral and extraoral closure.ResultsAll dogs that had mandibular reconstruction healed with intact gingival covering over the mandibular defect and had immediate return to normal function and occlusion. Mineralized tissue formation was observed clinically within 2 weeks and solid cortical bone formation within 3 months. CT findings at 3 months showed that the newly regenerated mandibular bone had ∼50% of the bone density and porosity compared to the contralateral side. No significant complications occurred.ConclusionMandibular reconstruction using internal fixation and CRM infused with rhBMP-2 is an excellent solution for immediate reconstruction of segmental mandibulectomy defects in dogs.
- Published
- 2015
17. Immediately loaded implants in a patient with involuntary mandibular movements: a clinical report.
- Author
-
Shek, Justin W, Plesh, Octavia, and Curtis, Donald A
- Subjects
Humans ,Mandibular Diseases ,Tongue Diseases ,Bruxism ,Dyskinesias ,Dental Implants ,Follow-Up Studies ,Dental Restoration Failure ,Dental Prosthesis ,Implant-Supported ,Denture ,Complete ,Lower ,Denture Design ,Denture ,Overlay ,Denture ,Partial ,Fixed ,Aged ,Patient Care Planning ,Female ,Immediate Dental Implant Loading ,Dental/Oral and Craniofacial Disease ,Bioengineering ,Rehabilitation ,Clinical Research ,Assistive Technology ,Dentistry ,Biomedical Engineering - Abstract
Immediately loaded implant prostheses have been used to successfully rehabilitate completely edentulous arches. Risk factors for successful treatment have not included involuntary mandibular movements. The treatment was completed on a patient with a history of neuroleptic medications who had remaining mandibular teeth extracted and then developed involuntary mandibular movements. The patient was dissatisfied with a mandibular removable prosthesis and wanted a fixed prosthesis. The immediate implant loading of a complete arch fixed prosthesis was delivered, and the patient lost 3 of the 6 implants. The patient continued to have problems with her definitive prostheses as the symptoms of her involuntary mandibular movements worsened.
- Published
- 2014
18. Stage 0 Osteonecrosis of the Jaw in a Patient on Denosumab
- Author
-
Aghaloo, Tara L, Dry, Sarah M, Mallya, Sanjay, and Tetradis, Sotirios
- Subjects
Dental/Oral and Craniofacial Disease ,2.1 Biological and endogenous factors ,Aetiology ,Adult ,Antibodies ,Monoclonal ,Humanized ,Bisphosphonate-Associated Osteonecrosis of the Jaw ,Cone-Beam Computed Tomography ,Denosumab ,Diagnosis ,Differential ,Giant Cell Tumors ,Humans ,Male ,Mandibular Diseases ,Osteonecrosis ,RANK Ligand ,Sacrum ,Spinal Neoplasms - Abstract
Osteonecrosis of the jaws (ONJ) is a complex disease involving multiple tissue and cell-type responses to wound healing or infection. AAOMS defines bisphosphonate related ONJ (BRONJ) as exposed, necrotic bone in the maxillofacial region that has persisted for more than 8 weeks in a patient with current or previous antiresorptive treatment, without a history of radiation therapy to the jaws. Since the first reported ONJ cases in 2003 and 2004, there has been little advancement in understanding the etiology and pathophysiology of ONJ. Many hypotheses have been proposed, including bisphosphonate (BP) toxicity to oral epithelium, altered wound healing after tooth extraction, high turnover of the mandible and maxilla, oral biofilm formation, infection and inflammation, and suppression of angiogenesis and bone turnover. The current classification system of ONJ involves stages 0 to 3 and is based on patient clinical presentation. This report describes a case of stage 0 ONJ in a patient on denosumab and indicates the full-spectrum similarities between BP- and denosumab-associated ONJ clinically, radiographically, and histologically.
- Published
- 2014
19. Therapeutic management of patients with class III skeletal malocclusion. Mandibular prognathism, maxillary retrognathism – a case report
- Author
-
Justyna Szpyt and Magdalena Gębska
- Subjects
prognathism ,mandibular diseases ,craniofacial abnormalities ,malocclusion ,angle class iii. ,Education ,Sports ,GV557-1198.995 ,Medicine - Abstract
Mandibular prognathism (progenism, underbite) is a type of malocclusion characterised by an abnormally anterior position of the mandible or the underdevelopment of the maxilla. The profile of an individual with the pathology is significantly prolonged in the sagittal plane, which distorts facial aesthetics. Underbite also negatively affects the entire masticatory function and may cause numerous ailments. Patients with prognathism struggle not only with aesthetic problems, but with functional issues as well. What is more, it can lead to difficulties in the psychosocial area of life by causing lower self-esteem and distorted self-image. Mandibular prognathism is treated with the use of orthodontic camouflage or combined orthodontic-surgical treatment, the latter method, despite its invasiveness, being the more popular one. An important element in the process of patient rehabilitation during treatment is the physiotherapist, who selects the right rehabilitation procedures aiming at the stomatognathic system. Even before the surgery itself, proper therapy begins whose task is preparing the craniofacial area for surgical invasion. After surgery, on the other hand, the physiotherapeutic procedures aim at the reduction of swelling, activating temporomandibular joints (TMJ), myofascial therapy, and special exercises (myokinesthetic therapy) which are aimed at supporting the adaptation of the body to a new morphological structure. This dissertation presents the case of a 19-year-old female patient with mandibular prognathism who underwent combined orhodontic-surgical treatment. The treatment consisted of Le Fort I osteotomy and bilateral sagittal split osteotomy (BSSO). The overall results of treatment were evaluated as very good.
- Published
- 2019
- Full Text
- View/download PDF
20. [Bilateral hyperplasia of the coronoid process in an adolescent patient. case report].
- Author
-
Fernández G, Hernández-Andara A, Manresa C, and Ortega-Pertuz AI
- Abstract
Hyperplasia of the coronoid process is a rare alteration that is characterized by the exaggerated and progressive development of said process over periods of months or years, both in height and volume, which finally causes mandibular hypomobility. It is important to highlight the importance of imaging for the correct diagnosis and treatment of said entity, taking into consideration the great variety of differential diagnoses that can occur. In this sense, conventional radiographs constitute a basic and indispensable tool for approaching the diagnosis. However, it is actually the CT scan that offers the greatest precision. The case of a 14-year-old male patient is presented, with no contributing medical history, who was referred for presenting progressive opening limitation since childhood, for which, after clinical and imaging evaluation, he was treated with total bilateral coronoidectomy, postoperative follow-up was performed. for a year in which recurrence of said entity could be observed. This case demonstrates the importance of correct diagnosis, as well as postoperative control and the rehabilitation scheme carried out by the patient., Competing Interests: Conflicto de intereses: Los autores declaran no tener conflictos de intereses
- Published
- 2024
- Full Text
- View/download PDF
21. Diagnostic Challenge and Clinical Management of Juvenile Mandibular Chronic Osteomyelitis.
- Author
-
Zimmermann, Caroline, Stuepp, Rúbia Teodoro, Rath, Inês Beatriz da Silva, Grando, Liliane Janete, Daniel, Filipe Ivan, and Meurer, Maria Inês
- Abstract
Juvenile mandibular chronic osteomyelitis (JMCO) is a rare, idiopathic disease of chronic bone inflammation without suppuration, sinus tract formation, or sequestration. As the name suggests, this condition predominately affects children. The few cases of JMCO reported in the literature describe different treatments, and thus a standard therapy protocol has not yet been established. The aim of this paper is to report a clinical case in a 9-year-old girl that was misdiagnosed and unsuccessfully treated for 1 year. After experiencing persistent symptoms, a correct diagnosis was subsequently rendered based on the physical and radiographic examination as well as successful treatment with non-steroidal anti-inflammatory drugs (NSAIDs). The patient received drug therapy followed by periods of remission over a 4 year follow-up period. Diagnosis and treatment of JMCO is a challenge given the rarity and nonspecific signs and symptoms of this condition. Treatment with NSAIDs and regular follow-up is a conservative option for these patients. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
22. Is Dose Volume a Better Predictor of Osteoradionecrosis Risk Than Total Dose for Patients Who Have Received Head and Neck Radiation?
- Author
-
Dean DeLuke, Caroline Carrico, Christopher Ray, Spiro Stilianoudakis, Sarah Holler, Laura Padilla, and Shiyu Song
- Subjects
Male ,Osteoradionecrosis ,Otorhinolaryngology ,Head and Neck Neoplasms ,Humans ,Female ,Mandibular Diseases ,Radiotherapy Dosage ,Surgery ,Radiotherapy, Intensity-Modulated ,Oral Surgery ,Retrospective Studies - Abstract
Oral and maxillofacial surgeons frequently encounter patients who require extractions following exposure to head and neck radiation, and they must assess the risk of extraction and consider alternatives such as deliberate root retention. The purpose of this study was to determine whether dose volume would be a better predictor for osteoradionecrosis (ORN) than total dose.This is a retrospective cohort study of patients diagnosed with ORN following head and neck radiation (administered between January 2006 and December 2018) and a comparison group selected based on site and dosage who did not develop ORN. The predictor variables were total radiation dose and mandibular dose volume, and the outcome variable was ORN occurrence. Covariates included age, sex, cancer stage and site, radiation therapy type, smoking status, alcohol use, adjuvant chemotherapy use, medical comorbidities, and concomitant tumor surgery. Logistic regression models were employed and area under receiver operating characteristic curve (AUROC) and model accuracy (Acc) were used to determine the better predictor.A total of 56 patients were included in the study: 27 ORN positive (ORN+) and 29 matched controls who did not develop ORN (ORN-). Most patients were male (76.8%), considered smokers (78.6%), used alcohol (80.4%), were in stage IV (66.1%), received chemotherapy (75.0%), and received intensity modulated radiation therapy radiation (55.4%). The statistical models with V50 Gy (cc) and V65 Gy (cc) dosage variables exhibited greater predictability of ORN occurrence than total dose (AUROC: 0.90 vs 0.76 and model accuracy: 0.82 vs 0.75, respectively).The results suggest that following head and neck radiation, dose volume may be a better predictor of ORN risk than total dose. This finding is significant, both for the oral and maxillofacial surgeon who is preoperatively assessing ORN risk following radiation exposure, and for the radiation oncologist striving to minimize the risk associated with their treatment.
- Published
- 2022
23. Central giant cell granuloma of the head & neck: A case report and systematic review
- Author
-
Jordan Richardson, Elizabeth Philipone, Kevin C. Lee, Dani Stanbouly, and Eric Litman
- Subjects
Male ,medicine.medical_specialty ,business.industry ,Head and neck cancer ,Retrospective cohort study ,medicine.disease ,Brown tumor ,Otorhinolaryngology ,Adrenal Cortex Hormones ,Granuloma, Giant Cell ,Median follow-up ,Temporal bone ,medicine ,Humans ,Mandibular Diseases ,Surgery ,Radiology ,Giant Cell Tumors ,Oral Surgery ,Differential diagnosis ,Child ,business ,Neck ,Central giant-cell granuloma ,Retrospective Studies - Abstract
Purpose: The purpose of this paper is to describe a recent case of central giant cell granuloma (CGCG) that rapidly progressed post corticosteroid treatment while also providing a review of the existing literature on CGCG of the head and neck (HNCGCG), with particular emphasis on extra-mandibular and maxillary cases. Materials and Methods: The investigators designed and implemented a 32-year review of literature, using the online databases: PubMed, Google Scholar, Medline, and Proquest. The total number of cases analyzed was 55 (42 case reports; 3 case series; 8 comparative studies; 1 retrospective cohort). Case Presentation: We present a case of a CGCG in a 10-year old male. The lesion originated in the right anterior mandibular body and progressed after corticosteroid treatment. Diagnosis was made using a combination of imaging and histology. A timely debulking procedure of the hemi-mandible was performed and there was no recurrence of the lesion at follow up. Results: The average age at the time of diagnosis of CGCG was 27.5 years. HNCGCG was most commonly detected in the jaw (43.1%), but was also found in the temporal bone (33.3%). The most frequently employed treatment modality was complete surgical excision (76.9%). 93.2% of patients were alive with no evidence of disease at follow-up, while 6.8% of patients exhibited recurrence at follow-up. The median follow up was 13 months. Conclusion: It is important for clinicians to recognize that CGCGs are capable of manifesting outside of the jaw. CGCG should be considered in the differential diagnosis of non-odontogenic radiolucent lesions, especially in young patients. CGCGs also need to be distinguished from brown tumor of hyperparathyroidism (BTH) and giant cell tumors, which are histologically similar.
- Published
- 2022
24. Predictive factors of osteoradionecrosis necessitating segmental mandibulectomy: A descriptive study
- Author
-
Eric C. Sung, Keith E. Blackwell, and Theodore V. Tso
- Subjects
medicine.medical_specialty ,Osteoradionecrosis ,Osteoporosis ,Mandibular Osteotomy ,Mandible ,Pathology and Forensic Medicine ,medicine ,Humans ,Mandibular Diseases ,Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Stage (cooking) ,Retrospective Studies ,Periodontitis ,business.industry ,Medical record ,Cancer ,Plastic Surgery Procedures ,medicine.disease ,Primary tumor ,Segmental Mandibulectomy ,Surgery ,Oral Surgery ,business - Abstract
Objective The objective of this study was to assess characteristics of patients with mandibular osteoradionecrosis (ORN) of severity necessitating segmental mandibulectomy and osteocutaneous free flap reconstruction. Study Design This study is a retrospective review of patients who underwent free flap reconstruction of the mandible at the UCLA Medical Center between January 2016 and February 2020 secondary to ORN. Results Twenty-nine charts with detailed dental and medical records were identified. Hypertension was reported in 14 of 29 patients, diabetes in 2 of 29, osteoporosis in 2 of 29, antiresorptive use in 3 of 29, tobacco use in 15 of 29, and alcohol use in 19 of 29. Twenty-three patients initially had stage III-IV cancer. The median radiation dose was 68 Gy and median time to ORN was 5.2 years. Chemotherapy was given in 21 patients and 4 had previous mandibular surgery. Twelve of 29 patients had surgical procedures identified as the causative factor and 17 of 29 occurred spontaneously. Median decayed, missing, and filled teeth score was 17 and 17 of 29 patients had grade II-IV periodontitis. Periodontitis was present in 8 of 17 of spontaneous and 1 of 12 of surgery cases. Twenty-five of 29 cases occurred in the same oral sextant as the tumor. Conclusion Severe ORN occurred at doses >60 Gy in most cases. Location of the primary tumor was predictive of site of ORN and only molars were involved when precipitated by tooth extraction. Risk of ORN persists indefinitely.
- Published
- 2022
25. Clinical and radiologic spectrum of glandular odontogenic cysts: A multicenter study of 92 cases
- Author
-
Liam Robinson, Ana Luiza Oliveira Corrêa Roza, Jason G. Ker-Fox, Alan Roger dos Santos Silva, Nathália Rodrigues Gomes, Mário José Romañach, Willie F. P. van Heerden, Pablo Agustin Vargas, and Chané Nel
- Subjects
Adult ,Male ,Nasal cavity ,medicine.medical_specialty ,Adolescent ,Maxillary sinus ,Mandible ,Pathology and Forensic Medicine ,Lesion ,Young Adult ,Oral and maxillofacial pathology ,Maxilla ,Humans ,Medicine ,Mandibular Diseases ,Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Aged ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Retrospective cohort study ,Middle Aged ,medicine.disease ,medicine.anatomical_structure ,Radiological weapon ,Odontogenic Cysts ,Female ,Surgery ,Radiology ,Oral Surgery ,medicine.symptom ,business ,Brazil - Abstract
Objective : The purpose of this multicenter retrospective study was to report the clinical and radiological features of 92 glandular odontogenic cysts (GOCs) diagnosed over a 20-year period. Study Design : Histologically confirmed cases of GOC were retrospectively reviewed from four Oral Pathology laboratories in South Africa and Brazil to categorize the clinical and radiological spectrum of GOCs. Results : The mean age of patients was 46 years (range 17-87) with a male-to-female ratio of 1.2:1. GOCs had a mandibular predilection (68%), with 42% of all cases located anteriorly. Additionally, 42% of cases crossed the midline. Radiologically, most lesions were unilocular (53%) and uniformly radiolucent (97%), with well-demarcated borders (93%). Cortical expansion (62%), loss of cortical integrity (71%), and maxillary sinus (67%) and nasal cavity encroachment (72%) were common findings. Significant differences in lesions between the two countries were discovered in sex predilection, clinical signs and symptoms, and lesion locations within the mandible and maxilla. Conclusion : GOCs present with a wide spectrum of clinical and radiological features, ranging from cysts with typical GOC-like presentations to more aggressive lesions. The need for advanced imaging in the surgical planning of GOCs exhibiting radiological signs of aggression is justified based on the high recurrence rate.
- Published
- 2022
26. Relationship between stomatognathic alterations and idiopathic scoliosis: a systematic review with meta-analysis of observational studies.
- Author
-
Gámiz-Bermúdez F, Ibáñez-Vera AJ, Obrero-Gaitán E, Cortés-Pérez I, Zagalaz-Anula N, and Lomas-Vega R
- Abstract
Purpose: The objective of this systematic review was to assess a possible relationship between stomatognathic alterations and idiopathic scoliosis (IS)., Design: This study is a systematic review with meta-analysis of observational studies., Methods: The protocol of this systematic review with meta-analysis was registered in PROSPERO (CRD42022370593). A bibliographic search was carried out in the Pubmed (MEDLINE), Scopus, Web of Science and CINAHL databases using the MeSH terms 'Scoliosis' and 'Stomatognathic Disease'. The odds ratio (OR) of prevalence and standardized mean difference (SMD) were used to synthesize the results., Results: Of 1592 studies located, 14 studies were selected with 3018 subjects (age: 13.9 years). IS was related to Angle's class II (OR = 2.052, 95% CI = 1.236-3.406) and crossbite (OR = 2.234, 95% CI = 1.639-3.045). Patients with malocclusion showed a higher prevalence of IS than controls (OR = 4.633, 95% CI = 1.467-14.628), and subjects with IS showed high overjet (SMD = 0.405, 95% CI = 0.149-0.661) and greater dysfunction due to temporomandibular disorders (SMD = 1.153, 95% CI = 0.780-1.527)., Conclusion: Compared with healthy controls, subjects with IS have twice the risk of suffering from occlusion disorders, present greater temporomandibular dysfunction and have a greater overjet in the incisors. Moreover, subjects with malocclusion have an IS prevalence up to four times higher. The systematic orofacial examination of patients with IS should be recommended.
- Published
- 2023
- Full Text
- View/download PDF
27. Unique case of glandular odontogenic cyst showing mucoepidermoid carcinoma-like islands in cystic wall
- Author
-
Rahul Yadav, Harpreet Kaur, and Deepika Mishra
- Subjects
0301 basic medicine ,Male ,Pathology ,medicine.medical_specialty ,Intraosseous mucoepidermoid carcinoma ,Case Report ,Diagnosis, Differential ,03 medical and health sciences ,0302 clinical medicine ,Mucoepidermoid carcinoma ,Glandular odontogenic cyst ,medicine ,Humans ,Mandibular Diseases ,Cellular atypia ,business.industry ,Mandible ,General Medicine ,Jaw cyst ,Middle Aged ,medicine.disease ,Odontogenic ,030104 developmental biology ,030220 oncology & carcinogenesis ,Odontogenic Cysts ,business ,Male predominance - Abstract
Glandular odontogenic cyst (GOC) is a very rare jaw cyst accounting for 0.2% of all odontogenic cysts. It presents usually in adults with a slight male predominance. It shows radiological, histopathological and even immunohistochemical overlap with low grade intraosseous mucoepidermoid carcinoma (MEC) but their distinction is crucial. A 57-year-old woman with bilocular radiolucency in the anterior mandible crossing the midline is described here. Microscopy features were consistent with glandular odontogenic cyst but multiple MEC-like islands were seen in the capsule, creating a diagnostic head trip with low grade intraosseous MEC. However, the absence of cellular atypia and epidermoid and intermediate cells led to a final diagnosis of GOC, with close follow-up of the patient recommended. This rare finding shows the relation between GOC and MEC or the origin of MEC from GOC.
- Published
- 2023
28. Dilemma in the Treatment of a Central Giant Cell Granuloma
- Author
-
Alfred Beham, Wolfgang Zemann, Astrid Toferer, Lisa Merl, Bernadette Liegl-Atzwanger, and Astrid Truschnegg
- Subjects
Male ,medicine.medical_specialty ,Surgical approach ,Functional impairment ,business.industry ,Mandible ,General Medicine ,medicine.disease ,Combined Modality Therapy ,Anterior region ,Surgery ,Lesion ,Combined treatment ,Adrenal Cortex Hormones ,Granuloma, Giant Cell ,medicine ,Humans ,Mandibular Diseases ,medicine.symptom ,Child ,business ,Central giant-cell granuloma ,High recurrence rate - Abstract
Management of central giant cell granuloma (CGCG) presents a clinical challenge. While eradicating a lesion known for its high recurrence rate calls for radical surgical approaches, these cause significant esthetic and functional impairment. We present an eight-year-old boy suffering from an extraordinarily large CGCG expanding into the mandible and base of the mouth in the whole anterior region. Combined treatment with surgical intervention and corticosteroid application was successfully applied, and all six attached dental germs could be preserved. Different approaches for clinical management in pediatric cases are discussed.
- Published
- 2021
29. Normal Tissue Complication Probability (NTCP) Prediction Model for Osteoradionecrosis of the Mandible in Patients With Head and Neck Cancer After Radiation Therapy
- Author
-
Mohamed A. Naser, Jillian M. Rigert, Stephen Y. Lai, Clifton D. Fuller, Lisanne V. van Dijk, Katherine A. Hutcheson, Abdallah S.R. Mohamed, and Abdelrahman A Abusaif
- Subjects
Male ,Cancer Research ,medicine.medical_specialty ,PROGNOSIS ,Osteoradionecrosis ,medicine.medical_treatment ,030218 nuclear medicine & medical imaging ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Clinical endpoint ,Humans ,Mandibular Diseases ,Radiology, Nuclear Medicine and imaging ,IMRT ,OPTIMIZATION ,Aged ,Probability ,Radiation ,business.industry ,Head and neck cancer ,HUMAN-PAPILLOMAVIRUS ,Area under the curve ,Radiotherapy Dosage ,Middle Aged ,medicine.disease ,Radiation therapy ,Oncology ,Dental extraction ,JAW ,Head and Neck Neoplasms ,030220 oncology & carcinogenesis ,Cohort ,RISK-FACTORS ,Female ,Radiology ,business ,Complication ,RADIOTHERAPY - Abstract
Purpose: Osteoradionecrosis (ORN) of the mandible represents a severe, debilitating complication of radiation therapy (RT) for head and neck cancer (HNC). At present, no normal tissue complication probability (NTCP) models for risk of ORN exist. The aim of this study was to develop a multivariable clinical/dose-based NTCP model for the prediction of ORN any grade (ORNI-IV) and grade IV (ORNIV) after RT (+/- chemotherapy) in patients with HNC.Methods and Materials: Included patients with HNC were treated with (chemo-)RT between 2005 and 2015. Mandible bone radiation dose-volume parameters and clinical variables (ie, age, sex, tumor site, pre-RT dental extractions, chemotherapy history, postoperative RT, and smoking status) were considered as potential predictors. The patient cohort was randomly divided into a training (70%) and independent test (30%) cohort. Bootstrapped forward variable selection was performed in the training cohort to select the predictors for the NTCP models. Final NTCP model(s) were validated on the holdback test subset.Results: Of 1259 included patients with HNC, 13.7% (n = 173 patients) developed any grade ORN (ORNI-IV primary endpoint) and 5% (n = 65) ORNIV (secondary endpoint). All dose and volume parameters of the mandible bone were significantly associated with the development of ORN in univariable models. Multivariable analyses identified D30% and pre-RT dental extraction as independent predictors for both ORNI-IV and ORNIV best-performing NTCP models with an area under the curve (AUC) of 0.78 (AUCvalidation = 0.75 [0.69-0.82]) and 0.81 (AUCvalidation = 0.82 [0.74-0.89]), respectively.Conclusions: This study presented NTCP models based on mandible bone D30% and pre-RT dental extraction that predict ORNI-IV and ORNIV (ie, needing invasive surgical intervention) after HNC RT. Our results suggest that less than 30% of the mandible should receive a dose of 35 Gy or more for an ORNI-IV risk lower than 5%. These NTCP models can improve ORN prevention and management by identifying patients at risk of ORN. (C) 2021 The Author(s). Published by Elsevier Inc.
- Published
- 2021
30. Non-surgical treatment as an alternative for the management of central giant cell granuloma: a systematic review
- Author
-
Elen de Souza Tolentino and Camila Camarini
- Subjects
medicine.medical_specialty ,Triamcinolone acetonide ,Bone Density Conservation Agents ,Ossification ,business.industry ,Plastic Surgery Procedures ,medicine.disease ,Bone remodeling ,Surgery ,Lesion ,Denosumab ,Granuloma, Giant Cell ,Calcitonin ,medicine ,Humans ,Mandibular Diseases ,medicine.symptom ,business ,General Dentistry ,Contraindication ,Central giant-cell granuloma ,medicine.drug - Abstract
To evaluate the effectiveness of non-surgical treatment as an alternative in the management of central giant cell granuloma (CGCG). A literature search was carried out in accordance with the PRISMA statement in order to answer the question “Are non-surgical treatments effective as an alternative in the treatment of CGCG?”. Two examiners independently assessed eligibility, risk of bias, and extracted data, which included therapeutic protocol, side effects, and need for surgical supplementation. Among 1712 studies, 15 were included, totaling 145 patients. Calcitonin, intralesional corticosteroids, and denosumab were the medications used. For calcitonin (n = 61), complete remission was found in 30 cases. For intralesional triamcinolone (n = 68), reduction in size was observed in most cases (n = 39). Four cases received subcutaneous denosumab and showed absence of active bone metabolism in the region, of which three presented ossification. Combination of drug therapies (n = 29) was reported in one study and included subcutaneous interferon and oral imatinib. More and less side effects were found for interferon and corticosteroids, respectively. Forty percent of patients required additional surgical treatment. Despite the side effects presented and the need for additional surgery in some patients, in general, all non-surgical treatments could provide positive results as an alternative for the management of CGCG, especially with regard to reducing the size of the lesion. CGCG is a benign bone lesion that mainly affects young individuals. Although the most common therapy is surgery, its contraindication in some patients, the large extension, and high recurrence rate of the aggressive variant have led the search for non-surgical therapies.
- Published
- 2021
31. Radiographic extent of maxillofacial Gorham's disease and its impact on recurrence: A systematic review
- Author
-
Kaustubh Sansare, V Sreenivasan, Mohd Saalim, Freny R Karjodkar, and Madhuri Jogdand
- Subjects
Adult ,Bone disease ,Radiography ,Dentistry ,Mandible ,Pathology and Forensic Medicine ,Lesion ,03 medical and health sciences ,0302 clinical medicine ,stomatognathic system ,Age groups ,Recurrence ,Humans ,Medicine ,Mandibular Diseases ,Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,business.industry ,Syndrome ,030206 dentistry ,Middle Aged ,medicine.disease ,Young age ,030220 oncology & carcinogenesis ,Maxilla ,Osteolysis, Essential ,Surgery ,Gorham's disease ,Oral Surgery ,medicine.symptom ,business - Abstract
Objective This systematic review assessed the radiographic extent of maxillofacial Gorham's disease and its impact on recurrence. Study Design PubMed and Cochrane databases were searched. The key words were (Gorham Disease OR Vanishing Bone Disease OR Gorham Stout Syndrome) AND (Jaw OR Maxilla OR Mandible OR Maxillofacial). Results Forty-one cases from 39 articles were included. Based on radiographic extent, the lesions were classified as large or small. Most cases occurred in the mandible (24), followed by a combination of maxilla and/or mandible and other bones (12), both mandible and maxilla (3), and maxilla only (2). Only mandibular cases were analyzed for radiographic extent. Of the 24 mandibular lesions, 16 were large and 8 were small. Nine of the large lesions occurred in the young age group with 2 recurrences, followed by 5 in the middle-aged group with 1 recurrence. Small lesions were nearly equally distributed over the age groups, with 2 recurrences in the middle-aged group and 1 recurrence in the adult age group. Age, sex, and lesion size had no significant effect on recurrence. Conclusions Radiographic extent of the lesion does not impact recurrence, suggesting a possible existence of aggressive and nonaggressive variants of maxillofacial Gorham's disease.
- Published
- 2021
32. THE ROLE OF OCCLUSAL FACTORS IN TEMPORO MANDIBULAR DISEASES – A SYSTEMATIC REVIEW
- Author
-
Chakradhar, Pallavi C, Sruthi Yss Sruthi Yss, Parvathi Pshl Parvathi Pshl, and Rao Bl
- Subjects
Orthodontics ,business.industry ,Mandibular Diseases ,Medicine ,business - Published
- 2021
33. Osteoradionecrosis and Proton Therapy.
- Author
-
Chiu KW and Kao YS
- Subjects
- Humans, Radiotherapy Dosage, Proton Therapy adverse effects, Osteoradionecrosis etiology, Osteoradionecrosis therapy, Mandibular Diseases
- Published
- 2023
- Full Text
- View/download PDF
34. Osteoradionecrosis and Proton Therapy-Reply.
- Author
-
Singh A, Lee NY, and Estilo CL
- Subjects
- Humans, Radiotherapy Dosage, Proton Therapy adverse effects, Osteoradionecrosis etiology, Mandibular Diseases
- Published
- 2023
- Full Text
- View/download PDF
35. Expansile mandibular radiolucency in a young adult female.
- Author
-
Alshagroud R, Alhadlaq M, Alswaidan M, Alomar A, and Tapia JL
- Subjects
- Humans, Female, Young Adult, Mandible, Mandibular Diseases, Mandibular Neoplasms diagnostic imaging, Mandibular Neoplasms surgery
- Abstract
Competing Interests: Disclosure None.
- Published
- 2023
- Full Text
- View/download PDF
36. [Radiolucency at both lower third molars: the paradental cyst]
- Author
-
G.J.C. van Baar, J.N. Lodders, and J.G.A.M. de Visscher
- Subjects
Adult ,Male ,Young Adult ,Face ,Humans ,Mandibular Diseases ,Molar, Third ,General Medicine ,Mandible ,Periodontal Cyst - Abstract
A 23-year-old man presented with an irritating sensation at the third molar on the left side of the mandible and a bad taste in his mouth. Radiographic and histopathological examination revealed the abnormality was caused by a paradental cyst. The paradental cyst is located distal to a lower third molar and, together with the mandibular buccal bifurcation cyst, belongs to the inflammatory collateral cysts. Treatment consists of enucleation of the cyst and removal of the lower third molar. Recurrences do not occur.Een 23-jarige man presenteerde zich met een irriterende sensatie ter plaatse van gebitselement 38 en een vieze smaak. Na röntgenologisch en histopathologisch onderzoek bleek de afwijking te berusten op een paradentaire cyste. De paradentaire cyste is distaal van een derde ondermolaar gelegen en behoort samen met de mandibulaire buccale bifurcatie cyste tot de inflammatoire collaterale cysten. Behandeling bestaat uit enucleatie van de cyste en verwijdering van de derde ondermolaar. Recidieven komen niet voor.
- Published
- 2022
37. Mandibular Buccal Bifurcation Cyst: Report of Two Cases
- Author
-
Liu, Yao-Ran, Chen, Ji-Rong, Wang, Lei, Ouyang, Ke-Xiong, and Huang, Luo
- Subjects
Leukocyte Count ,Odontogenic Cysts ,Humans ,Mandibular Diseases ,Periodontal Cyst ,Molar - Abstract
Mandibular buccal bifurcation cyst is a rare inflammatory odontogenic cyst. We reported two cases who complained of painful swelling of extraoral soft tissue. Intraoral examination revealed the partially erupted mandibular first molar. Cone beam computed tomography showed a well-defined cystic lesion surrounding the first molar. Histopathologic images showed the cyst wall was infiltrated by a large number of plasma cells, neutrophils and eosinophils, and lined with a thin layer of non-keratinized stratified squamous epithelium. Finally, the two patients were diagnosed as mandibular buccal bifurcation cyst and treated with cyst enucleation and curettage.
- Published
- 2022
38. [Aneurysmal bone cyst of mandible: report of a case]
- Author
-
J W, Ao and Q R, Chen
- Subjects
Bone Cysts, Aneurysmal ,Humans ,Mandibular Diseases ,Mandible - Abstract
动脉瘤样骨囊肿(aneurysmal bone cysts,ABC)好发于儿童和青少年的长骨,原发于颅面骨的ABC相对罕见。本文报道1例发生于6岁儿童下颌骨的囊肿性病变,描述其影像学、病理形态学特征以及分子检测发现USP6基因重排,最后确诊为下颌骨ABC。第5版WHO骨和软组织肿瘤分类把ABC归属于富于破骨巨细胞的病变,多伴有USP6基因重排,是一种良性肿瘤。发生于手足小骨的巨细胞病变也具有USP6基因重排,第5版WHO将其也归于ABC。本文关注颌骨富于巨细胞的几种病变的诊断与鉴别诊断,强调组织形态学、分子检测和影像学相结合正确诊断ABC的重要性。.
- Published
- 2022
39. Factors Associated with Treatment Outcomes and Pathological Features in Patients with Osteoradionecrosis: A Retrospective Study
- Author
-
Yoshiaki Tadokoro, Takumi Hasegawa, Daisuke Takeda, Aki Murakami, Nanae Yatagai, Eiji Iwata, Izumi Saito, Junya Kusumoto, and Masaya Akashi
- Subjects
Fistula ,Health, Toxicology and Mutagenesis ,Public Health, Environmental and Occupational Health ,extensive resection ,sequestration ,osteoradionecrosis ,radiation dose ,orocutaneous fistula ,Treatment Outcome ,Osteoradionecrosis ,Head and Neck Neoplasms ,Humans ,Mandibular Diseases ,Retrospective Studies - Abstract
A standard treatment for osteoradionecrosis (ORN) has not yet been established because of the diversity. Therefore, identifying the risk factors for a poor prognosis is essential. This study retrospectively investigated the factors associated with the prognosis of ORN in 68 patients. Relevant clinical data of all patients were obtained. Of the patients, 16 who underwent extensive surgery underwent histopathological analysis. The necrotic changes of the anterior and posterior margins in the cortical and cancellous bones were investigated. Multivariate analyses showed statistically significant associations between poor prognosis in patients with ORN and high radiation dose (hazard ratio [HR] 1.15), orocutaneous fistula (HR 2.93), and absence of sequestration (HR 2.49). Histopathological analysis showed a viable anterior margin of the middle portion of the cortical bone for all recovered cases; in contrast, most cases (75%) with a poor prognosis showed necrotic changes. The anterior margin of the cancellous bone was viable and resilient to high irradiation, regardless of the prognosis. These results suggest that patients with orocutaneous fistula should receive early surgical intervention, even if the affected area is limited or asymptomatic. In extensive surgery, a sufficient safety margin of necrotic bone, particularly in the anterior region, is required to improve the prognosis.
- Published
- 2022
40. Huge Facial Desmoid Tumors with Neck Extension: A Case Report
- Author
-
Ali Ghazipour, Shervin Ghavami Lahiji, Bassel Bradd, and Fariborz Saleheh
- Subjects
Fibromatosis ,Fibrous Tissue ,Mandibular Diseases ,Neoplasms ,Otorhinolaryngology ,RF1-547 - Abstract
Introduction: Desmoid tumors are very rare, benign fibrous neoplasms arise from the musculoaponeurotic structures throughout the body. Case Report: The patient was a seven-year old boy with a large mandibular mass growing over a period of six months. His CT-scan showed a large mass, 13 cm in diameter in the cheek area extending to the neck and trachea. Biopsy was compatible with desmoid fibromatosis. He was given neoadjovant treatment with vinblastin and methotrexate. The patient underwent a tracheostomy. Then a complete hemimandibulectomy and submandibular gland excision was performed. Finally reconstruction with latisimus dorsi free flap was performed. Conclusion: Despite rarity desmoid tumors should be kept in mind of an otorhinolaryngologist as a differential diagnosis in children with head and neck mass.
- Published
- 2014
41. Mandibular radiolucency with snowflakelike calcifications
- Author
-
Galal Omami
- Subjects
Diagnosis, Differential ,Orthodontics ,Mandibular Neoplasms ,business.industry ,Mandibular Diseases ,Radiodensity ,Tooth, Impacted ,Humans ,Medicine ,Mandible ,business ,General Dentistry - Published
- 2021
42. Is Adjunctive Hyperbaric Oxygen Treatment Alone or with Surgery the Proper Management for Active and Persistent Osteoradionecrosis?
- Author
-
Ajanee Mahakkanukrauh, Patravoot Vatanasapt, Suthin Jinaporntham, Kamonwan Jenwitheesuk, Wiyada Punjaruk, Palakorn Surakunprapha, Kriangsak Jenwitheesuk, Krittinant Uraiwan, and Phasuk Limrattanapimpa
- Subjects
Adult ,Male ,medicine.medical_specialty ,Osteoradionecrosis ,MEDLINE ,Dermatology ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Hyperbaric oxygen ,Primary outcome ,medicine ,Humans ,Mandibular Diseases ,Multiple logistic regression analysis ,Stage (cooking) ,Aged ,Retrospective Studies ,Advanced and Specialized Nursing ,Hyperbaric Oxygenation ,Wound Healing ,Radiotherapy ,business.industry ,030208 emergency & critical care medicine ,Middle Aged ,Plastic Surgery Procedures ,Thailand ,medicine.disease ,Combined Modality Therapy ,Anti-Bacterial Agents ,Osteotomy ,Surgery ,Treatment Outcome ,Head and Neck Neoplasms ,Treatment modality ,Female ,business ,Wound healing - Abstract
This study enrolled patients with stage 3 osteoradionecrosis. There were three treatment modalities: antibiotics, hyperbaric oxygen therapy (HBOT), and surgery. Complete healing was the primary outcome. Multiple logistic regression analysis demonstrated that surgery with HBOT improved wound healing better than HBOT alone.
- Published
- 2021
43. Nutritional status in patients of mandibular osteoradionecrosis: A single‐institution experience
- Author
-
Caibing Xiong, Jingjing Ye, Qiuyu Huang, Zhumei Lin, Xingfang He, Wei-fa Yang, and Yujie Liang
- Subjects
medicine.medical_specialty ,Liquid diet ,Osteoradionecrosis ,Nutritional Status ,Mandible ,Logistic regression ,03 medical and health sciences ,0302 clinical medicine ,Quality of life ,Internal medicine ,Humans ,Medicine ,Mandibular Diseases ,General Dentistry ,Retrospective Studies ,business.industry ,Head and neck cancer ,Nutritional status ,030206 dentistry ,medicine.disease ,Malnutrition ,Cross-Sectional Studies ,Otorhinolaryngology ,Head and Neck Neoplasms ,030220 oncology & carcinogenesis ,Quality of Life ,business ,Complication - Abstract
BACKGROUND Mandibular osteoradionecrosis (ORN) is a devastating complication secondary to the radiotherapy of head and neck cancer. The nutritional status of ORN patients is compromised, but remains rarely studied. We aimed to evaluate the overall nutritional status of patients with ORN and explore the risk factors behind poor nutrition. METHODS This is a single-institution cross-sectional study. Patients diagnosed with ORN were consecutively recruited in a tertiary teaching hospital from July 2017 to August 2019. Multiple laboratory markers and physical indicators were examined to profile their nutritional status. The potential risk factors of poor nutrition were explored by logistic regression. RESULTS A total of 107 patients with ORN were recruited. Among them, almost all patients (95.3%) had at least one laboratory marker lower than the normal physiological range. A total of 40 (37.5%) patients were categorized as undernutrition, who had lower serum albumin (mean difference: 1.8 ± 0.8 g/L; p = .02), prealbumin (mean difference: 26.8 ± 10.8 mg/L; p = .02), and BMI (3.8 ± 0.4 kg/m2 ; p
- Published
- 2021
44. Does the administration of meloxicam before head and neck radiotherapy reduce the risk of mandibular osteoradionecrosis? An animal model study
- Author
-
Matheus Lima Oliveira, Lourenço Correr-Sobrinho, Leonardo Vieira Peroni, Eduarda Helena Leandro Nascimento, Mayra Cristina Yamasaki, Deborah Queiroz Freitas, Benjamin Salmon, and Gina Delia Roque-Torres
- Subjects
Male ,Molar ,medicine.medical_specialty ,Osteoradionecrosis ,medicine.medical_treatment ,Mandible ,Meloxicam ,03 medical and health sciences ,0302 clinical medicine ,Animal model ,Head and neck radiotherapy ,Animals ,Medicine ,Mandibular Diseases ,Rats, Wistar ,General Dentistry ,business.industry ,Radiation-protective agents ,X-Ray Microtomography ,030206 dentistry ,medicine.disease ,Pathophysiology ,Rats ,Surgery ,Radiation therapy ,Head and Neck Neoplasms ,030220 oncology & carcinogenesis ,business ,medicine.drug - Abstract
To assess whether the administration of meloxicam before head and neck radiotherapy reduces the risk of mandibular osteoradionecrosis in rats. Sixty male Wistar rats were randomly divided into 6 groups (n = 10) according to the meloxicam administration and radiation therapy: control (C), irradiated (I), single dose of meloxicam (M1), single dose of meloxicam and irradiated (M1I), triple dose of meloxicam (M3), triple dose of meloxicam and irradiated (M3I). Meloxicam was administrated (20 mg/kg per dose) 1 h before the radiation therapy (single dose of 20 Gy) and 24 h and 48 h after the radiation therapy for groups with two additional doses. Ten days after the radiation therapy, the three right mandibular molars were extracted from all rats, who were euthanatized after 21 or 35 days (n = 5 per group). The mandibles were assessed by macroscopic evaluation and micro-CT analysis. The right hemimandibles of the irradiated groups revealed macroscopic signs of osteoradionecrosis, and those of the non-irradiated groups revealed complete gingival healing. A significant delay in alveolar socket healing in all irradiated groups was observed in the micro-CT assessment regardless meloxicam treatment. The administration of meloxicam before head and neck radiotherapy does not reduce the risk of mandibular osteoradionecrosis when associated to dental extractions. Since meloxicam has been shown to be a potential radiation-protective agent, and osteoradionecrosis physiopathology is believed to be related to an inflammatory process, possible interactions are relevant to be investigated.
- Published
- 2021
45. Outcome of Mandibular Dentigerous Cysts 1 to 10 Years After Decompression Using a Custom-Made Appliance
- Author
-
Faysal Ugurlu, Serap Akyüz, and Ali Menteş
- Subjects
Decompression ,Dentigerous Cyst ,Culture ,Dentistry ,Mandible ,Dehiscence ,Inferior alveolar nerve ,03 medical and health sciences ,0302 clinical medicine ,stomatognathic system ,Premolar ,medicine ,Humans ,Mandibular Diseases ,Cyst ,Medical history ,Child ,Retrospective Studies ,business.industry ,Soft tissue ,Retrospective cohort study ,030206 dentistry ,medicine.disease ,medicine.anatomical_structure ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Surgery ,Oral Surgery ,business - Abstract
Purpose The aim of this study was to examine the long-term results of mandibular dentigerous cysts treated with decompression using a custom-made appliance. Patients and Methods This retrospective study included 34 patients with dentigerous cysts who were treated as outpatients at the Faculty of Dentistry, Marmara University. Medical history, complaints, intraoral and extraoral clinical findings, treatment time, and complications of these patients were collected. Results The average age of the patients was 7.94 years. Three tooth buds (canine, first permanent premolar [P1], and second permanent premolar) in 2 cases, two tooth buds in 7 cases (P1 and second permanent premolar in 6 cases and P1 and canine in 1 case), and one tooth bud in 25 cases were related to the cyst. The mean decompression time was 5.97 months (range, 3 to 9 months). No major complications occurred during or after decompression. No evidence of infection, breakdown and/or dehiscence of the soft tissue, or inferior alveolar nerve paresthesia was observed. The complications and complaints were minor and straightforward to resolve. Conclusions Decompression is a very effective and successful method for the treatment of mandibular dentigerous cysts.
- Published
- 2021
46. Quantitative Dynamic Contrast-Enhanced MRI Identifies Radiation-Induced Vascular Damage in Patients With Advanced Osteoradionecrosis: Results of a Prospective Study
- Author
-
Hoda Ahmed, Hesham Elhalawani, Baher Elgohari, Abdallah S.R. Mohamed, Renjie He, Andrew D. Kim, Mark S. Chambers, Yao Ding, Joint Head, Stephen Y. Lai, Clifton D. Fuller, Joly Fahim, Jihong Wang, Jose A Garcia, Jason M. Johnson, Vlad C. Sandulache, R. Jason Stafford, and James A. Bankson
- Subjects
Adult ,Male ,Cancer Research ,Time Factors ,Osteoradionecrosis ,medicine.medical_treatment ,Contrast Media ,Mandible ,Article ,Statistics, Nonparametric ,030218 nuclear medicine & medical imaging ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Mandibular Diseases ,Radiology, Nuclear Medicine and imaging ,Prospective Studies ,Radiation Injuries ,Prospective cohort study ,Aged ,Radiation ,medicine.diagnostic_test ,Squamous Cell Carcinoma of Head and Neck ,business.industry ,Head and neck cancer ,Dose fractionation ,Magnetic resonance imaging ,Middle Aged ,Institutional review board ,medicine.disease ,Magnetic Resonance Imaging ,Radiation therapy ,Oncology ,Head and Neck Neoplasms ,030220 oncology & carcinogenesis ,Dynamic contrast-enhanced MRI ,Blood Vessels ,Female ,Dose Fractionation, Radiation ,Radiotherapy, Intensity-Modulated ,Nuclear medicine ,business - Abstract
PURPOSE: We aim to characterize the quantitative dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) parameters associated with advanced mandibular osteoradionecrosis (ORN) compared with the contralateral normal mandible. METHODS AND MATERIALS: Patients with a diagnosis of advanced ORN after curative-intent radiation treatment of head and neck cancer were prospectively enrolled after institutional review board approval and study-specific informed consent were obtained. Quantitative maps generated with the Tofts and extended Tofts pharmacokinetic models were used for analysis. Manual segmentation of advanced ORN 3-dimensional volume was done using anatomic sequences to create ORN volumes of interest (VOIs). Subsequently, normal mandibular VOIs were segmented on the contralateral healthy mandible of similar volume and anatomic location to create control VOIs. Finally, anatomic sequences were coregistered to DCE sequences, and contours were propagated to the respective parameter maps. RESULTS: Thirty patients were included. The median time to ORN diagnosis after completion of IMRT was 38 months (range, 6–184 months), whereas median time to ORN progression to advanced grade after initial diagnosis was 5.6 months (range, 0–128 months). There were statistically significant higher K(trans) and V(e) in ORN-VOIs compared with controls (0.23 vs 0.07 min(−)(1), and 0.34 vs 0.15; P
- Published
- 2020
47. Effects of the Association of Periodontitis and Type 1 Diabetes Mellitus Induced on Periodontal Tissues and the Duodenal Mucosa of Wistar Rats
- Author
-
Rose Meire Costa Brancalhão, Sabrina Grassioli, Ediana Amanda Piana, Patricia Oehlmeyer Nassar, Franciane Wachter, Bianca Caroline Custodio dos Santos, Jossinelma Camargo Gomes, Carlos Augusto Nassar, and Iohana Ferreira Choptian Fiorese
- Subjects
0301 basic medicine ,medicine.medical_specialty ,endocrine system diseases ,Duodenum ,Immunology ,Alveolar Bone Loss ,Inflammation ,Permeability ,Diabetes Mellitus, Experimental ,Random Allocation ,03 medical and health sciences ,0302 clinical medicine ,immune system diseases ,Diabetes mellitus ,Internal medicine ,medicine ,Animals ,Immunology and Allergy ,Mandibular Diseases ,Intestinal Mucosa ,Rats, Wistar ,Periodontitis ,Dental alveolus ,Type 1 diabetes ,business.industry ,nutritional and metabolic diseases ,Inflammatory Bowel Diseases ,medicine.disease ,Streptozotocin ,Rheumatology ,Rats ,Radiography ,Diabetes Mellitus, Type 1 ,030104 developmental biology ,Endocrinology ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,medicine.symptom ,business ,human activities ,Biomarkers ,medicine.drug - Abstract
Forty Wistar rats were used: (1) control group (CG); (2) group of periodontal disease (PD); (3) type 1 diabetes mellitus group (T1DM); (4) type 1 diabetes mellitus + periodontal disease group (T1DM + PD). In groups T1DM and T1DM + PD, T1DM induction was performed with the administration of streptozotocin (STZ) 80 mg/kg intraperitoneal body weight. The PD and T1DM + PD groups were submitted to PD induction with ligation. After the experimental phase and euthanasia, histological, radiographic, and morphological analyses were performed. For data analysis, was used the one-way ANOVA and post-test Tukey. The T1DM + PD group had a significantly higher level of fasting blood glucose compared to the other groups. In radiographic and histomorphometric analyses, the T1DM + PD group showed greater alveolar bone loss compared to the control group. The T1DM + PD group showed greater osteoclastic activity compared to the control, T1DM, and PD groups and exhibited an intense inflammatory infiltrate, most of which were PMN, being that the amount of this group of cells (PMN) was significantly greater than the PD group. The heights of the intestinal villi were statistically higher in the PD, T1DM, T1DM + PD groups, compared to the control. Regarding the height of the crypt, only the T1DM and T1DM + PD groups were significantly higher compared to the other groups. Association of diabetes and periodontal inflammation increased the deleterious effects on bone tissue and adverse effect on the permeability of the duodenal mucosa.
- Published
- 2020
48. Three-Dimensional Biomodels: Use of Different Materials for the Surgical Planning in Relation to Two Mandibular Cysts Cases
- Author
-
Astigueta José Mariano, Mendoza Cuello Norbin José, Benitez Javier Alejandro, Attaguile Alberto, and Giannunzio Graciela Ana
- Subjects
Surgical results ,Surgical time ,Osteosynthesis ,Three dimensional imaging ,Relation (database) ,business.industry ,Mandibular Diseases ,Dentistry ,Medicine ,Pathological fractures ,business ,Surgical planning - Abstract
Introduction: The use of three-dimensional models in the diagnosis, planification and treatment of the maxillofacial area pathology has been included in publications since 1980, and has enabled to minimize surgical time, reducing peri and postoperative morbidity, and optimizing surgical results. Currently, the market offers a huge range of 3D printers and materials which allows biomodels to be printed for medical purposes. The purpose of the following paper is to describe the use of two types of three-dimensional models in the therapeutic planning of two cases of mandibular cysts. Case Report: Two cases of mandibular dentigerous cysts are described, in which osteosynthesis plates were used to prevent pathological fractures, pre-modeled together with acrylic positioners on three-dimensional models and printed in different ways. Postoperative clinical and tomographic controls were performed. Conclusion: The knowledge of the properties of the different materials available for the construction of three-dimensional models allows selecting the one that best suits the case needs required, minimizing surgical times and optimizing the results.
- Published
- 2020
49. Osteoradionecrosis after postoperative radiotherapy for oral cavity cancer: A retrospective cohort study
- Author
-
Michelle M. Möring, Hetty Mast, Eppo B. Wolvius, Gerda M. Verduijn, Steven F. Petit, Nienke D. Sijtsema, Brend P. Jonker, Remi A. Nout, Wilma D. Heemsbergen, Radiotherapy, Oral and Maxillofacial Surgery, and Radiology & Nuclear Medicine
- Subjects
Cohort Studies ,Cancer Research ,Oncology ,SDG 3 - Good Health and Well-being ,Osteoradionecrosis ,Head and Neck Neoplasms ,Humans ,Mandibular Diseases ,Mouth Neoplasms ,Radiotherapy Dosage ,Oral Surgery ,Retrospective Studies - Abstract
Objective: Osteoradionecrosis (ORN) is a severe late complication after radiotherapy but current knowledge on ORN risks in the setting of postoperative radiotherapy (PORT) is limited. We studied the incidence and risk factors of ORN in patients with oral cavity cancers (OCC, treated with PORT.Patients and Methods: A retrospective cohort study was conducted including OCC patients (mainly squamous cell) treated with postoperative intensity modulated radiotherapy between 2010 and 2018 with > 1 year disease-free survival. Cumulative incidences of ORN were computed using the Kaplan Meier method. Clinical and dosimetric risk factors for mandibular ORN were evaluated using Cox regression models.Results: Within our cohort (N = 227, median follow-up 49 months) we observed 46 cases of ORN, mainly in the mandible (n = 41). The cumulative incidence of mandibular ORN was 15.9 % (SE 2.5 %) at three years and 19.8 % (SE 3.0 %) at five years. At univariable analysis, smoking, mandibular mandibulotomy or segment resection, mean dose to the mandible, and mandible volume (%) >= 60 Gy (V60) were significantly associated with increased ORN risks. At multivariable analysis, smoking (HR 2.13, 95 %CI 1.12-4.06) and V60 (HR 1.02 per 1 % increase, 95 %CI 1.01-1.04) remained predictive factors. For active smokers with a high V60 >= 40 % we observed rapid ORN development with a 1-year incidence of 29 % vs 6 % for others (p < 0.01).Conclusion: OCC Patients treated with PORT are at high risk for mandibular ORN. We identified the mandibular volume receiving >= 60 Gy as the dominant risk factor, especially in active smokers. Limiting high-dose volumes at treatment planning may decrease ORN risks.
- Published
- 2022
50. Multilocular lesion of the mandibular body and Bilateral clusters of radiopacities
- Author
-
Galal, Omami
- Subjects
Mandibular Neoplasms ,Humans ,Mandibular Diseases ,Mandible - Published
- 2022
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.