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Your search keyword '"Manderveld, Ann"' showing total 7 results
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7 results on '"Manderveld, Ann"'

1. The Cancer Cell Oxygen Sensor PHD2 Promotes Metastasis via Activation of Cancer-Associated Fibroblasts

Author

Kuchnio, Anna, Moens, Stijn, Bruning, Ulrike, Kuchnio, Karol, Cruys, Bert, Thienpont, Bernard, Broux, Michaël, Ungureanu, Andreea Alexandra, Leite de Oliveira, Rodrigo, Bruyère, Françoise, Cuervo, Henar, Manderveld, Ann, Carton, An, Hernandez-Fernaud, Juan Ramon, Zanivan, Sara, Bartic, Carmen, Foidart, Jean-Michel, Noel, Agnes, Vinckier, Stefan, Lambrechts, Diether, Dewerchin, Mieke, Mazzone, Massimiliano, and Carmeliet, Peter

Published
2015
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2. Generation of vessel co-option lung metastases mouse models for single-cell isolation of metastases-derived cells and endothelial cells

Author

Cuypers, Anne, primary, Teuwen, Laure-Anne, additional, Bridgeman, Victoria L., additional, de Rooij, Laura P.M.H., additional, Eelen, Guy, additional, Dewerchin, Mieke, additional, Cantelmo, Anna Rita, additional, Kalucka, Joanna, additional, Bouché, Ann, additional, Vinckier, Stefan, additional, Carton, An, additional, Manderveld, Ann, additional, Vermeulen, Peter B., additional, Reynolds, Andrew R., additional, and Carmeliet, Peter, additional

Published
2022
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3. PARP1 inhibition and hypoxia enhance the endothelial phenotype in melanoma cells during vasculogenic mimicry

Author

Fernández-Cortés, Mónica, Bermúdez-Jiménez, Eloísa, García-Díaz, Ángel, Manderveld, Ann, Vinckier, Stefan, Carmeliet, Peter, and Oliver, Francisco Javier

Abstract

Vasculogenic mimicry (VM) describes the potential of highly aggressive tumor cells to develop vascular-like structures in the absence of endothelial cells (ECs). For this purpose, it is essential that tumor cells acquire certain molecular traits specific to ECs, such as expression of VE-cadherin (1). Oxygen deprivation, also known as hypoxia, has been repeatedly associated with VM, but the role of poly-(ADP-ribose) polymerase 1 (PARP1) in modulating VM remains largely unexplored. However, we have previously reported that there can be interplay between PARP1 and hypoxia response (2), and that PARP inhibition can affect VM (3). AIM: In this study, we aimed to define the role of hypoxia (1% O2) and PARP1 in modulating VM in highly aggressive melanoma cells. We have paid special attention to the expression of vascular markers, as well as the ability of tumor cells to engage tube formation in vitro. Moreover, we developed models of human uveal melanoma xenografts in nude mice, in order to evaluate tumor progression and tumor vasculature in vivo in response to olaparib treatment.

Published
2020

4. Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors

Author

Li, Xuri, Tjwa, Marc, Moons, Lieve, Fons, Pierre, Noel, Agnes, Ny, Annelii, Zhou, Jian Min, Lennartsson, Johan, Li, Hong, Luttun, Aernout, Pontén, Annica, Devy, Laetitia, Bouché, Ann, Oh, Hideyasu, Manderveld, Ann, Blacher, Silvia, Communi, David, Savi, Pierre, Bono, Françoise, Dewerchin, Mieke, Foidart, Jean-Michel, Autiero, Monica, Herbert, Jean-Marc, Collen, Désiré, Heldin, Carl-Henrik, Eriksson, Ulf, and Carmeliet, Peter

Published
2005

5. Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors

Author

Li, Xuri, primary, Tjwa, Marc, additional, Moons, Lieve, additional, Fons, Pierre, additional, Noel, Agnes, additional, Ny, Annelii, additional, Zhou, Jian Min, additional, Lennartsson, Johan, additional, Li, Hong, additional, Luttun, Aernout, additional, Pontén, Annica, additional, Devy, Laetitia, additional, Bouché, Ann, additional, Oh, Hideyasu, additional, Manderveld, Ann, additional, Blacher, Silvia, additional, Communi, David, additional, Savi, Pierre, additional, Bono, Françoise, additional, Dewerchin, Mieke, additional, Foidart, Jean-Michel, additional, Autiero, Monica, additional, Herbert, Jean-Marc, additional, Collen, Désiré, additional, Heldin, Carl-Henrik, additional, Eriksson, Ulf, additional, and Carmeliet, Peter, additional

Published
2004
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7. Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors.

Author

Xuri Li, Tjwa, Marc, Moons, Lieve, Fons, Pierre, Noel, Agnes, Ny, Annelii, Jian Mm Zhou, Lennartsson, Johan, Hong Li, Luttun, Aernout, Pontén, Annica, Devy, Laetitia, Bouché, Ann, Hideyasu Oh, Manderveld, Ann, Blacher, Silvia, Communi, David, Savi, Pierre, Bono, Françoise, and Dewerchin, Mieke

Subjects
*ISCHEMIA, *VASCULAR endothelial growth factors, *BONE marrow cells, *SMOOTH muscle, *IMMUNE system, *HEMATOPOIETIC system
Abstract

The angiogenic mechanism and therapeutic potential of PDGF-CC, a recently discovered member of the VEGF/ PDGF superfamily, remain incompletely characterized. Here we report that PDGF-CC mobilized endothelial progenitor cells in ischemic conditions; induced differentiation of bone marrow cells into ECs; and stimulated migration of ECs. Furthermore, PDGF-CC induced the differentiation of bone marrow cells into smooth muscle cells and stimulated their growth during vessel sprouting. Moreover, delivery of PDGF-CC enhanced postischemic revascularization of the heart and limb. Modulating the activity of PDGF-CC may provide novel opportunities for treating ischemic diseases. [ABSTRACT FROM AUTHOR]

Published
2005
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