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12. Recommandations pour la pratique clinique : grossesses après chirurgie bariatrique – Groupe BARIA-MAT

Author

Canale, C., Castera, V., Ciangura, C., Coupaye, M., Coutant, R., Deruelle, P., Dupré, T., Gascoin, G., Calabrese, D., Cosson, E., Ducarme, G., Gaborit, B., Joly, A.S., Johanet, H., Lelièvre, B., Mandelbrot, L., Petrucciani, N., Pigeyre, M., Quilliot, D., Ritz, P., Robin, G., Rochereau, B., Sallé, A., Taillard, V., Gugenheim, J., and Nizard, J.

Published
2019
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24. OP02.09: Cortical maturation assessed by magnetic resonance imaging in unaffected/mildly affected fetuses with CMV infection

Author

Hawkins‐Villarreal, A.M., primary, Moreno‐Espinosa, A.L., additional, Castillo, K.P., additional, Hahner, N.M., additional, Martinez‐Portilla, R.J., additional, Picone, O., additional, Mandelbrot, L., additional, Simon, I., additional, Gratacós, E., additional, Goncé, A., additional, and Eixarch, E., additional

Published
2022
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31. Safety of protease inhibitors in HIV-infected pregnant women

Author

Chougrani I, Luton D, Matheron S, Mandelbrot L, and Azria E

Subjects
Immunologic diseases. Allergy, RC581-607
Abstract

Imène Chougrani,1 Dominique Luton,1,2 Sophie Matheron,3 Laurent Mandelbrot,2,4 Elie Azria1,2 1Department of Obstetrics and Gynecology, Bichat Claude Bernard Hospital, Paris Diderot University, Paris, 2Departement Hospitalo-Universitaire "Risk and Pregnancy", Paris, 3Department of Infectious and Tropical Diseases, Bichat Claude Bernard Hospital, Paris Diderot University, Paris, 4Department of Obstetrics and Gynecology, Louis Mourier Hospital, Paris Diderot University, Colombes, France Abstract: The dire conditions of the human immunodeficiency virus/acquired immune deficiency syndrome epidemic and the immense benefits of antiretroviral prophylaxis in prevention of mother-to-child transmission far outweigh the potential for adverse effects and undeniably justify the rapid and widespread use of this therapy, despite incomplete safety data. Highly active antiretroviral therapy has now become standard care, and more than half the validated regimens include protease inhibitors. This paper reviews current knowledge of the safety of these drugs during pregnancy, in terms of maternal and fetal outcomes. Transfer of protease inhibitors across the placenta is known to be minimal, and current data about birth defects and fetal malignancies are reassuring. Maternal liver function and glucose metabolism should be monitored in women treated with protease inhibitor-based regimens, but concerns about the development of maternal resistance, should treatment be discontinued, have been shown to be groundless. Neonates should be screened for hematologic abnormalities, although these are rarely severe or permanent and are not usually related to the protease inhibitor component of the antiretroviral combination. Current findings concerning pre-eclampsia and growth restriction are discordant, and further research is needed to address the question of placental vascular complications. The increased risk of preterm birth attributed to protease inhibitors should be interpreted with caution considering the discrepant results and the multitude of confounding factors often overlooked. Although data are thus far reassuring, further research is needed to shed light on unresolved controversies about the safety of protease inhibitors during pregnancy. Keywords: human immunodeficiency virus, pregnancy, protease inhibitors

Published
2013

35. Differential rates of cesarean delivery by maternal geographical origin: a cohort study in France

Author

Linard, M, Deneux-Tharaux, C, Luton, D, Schmitz, T, Mandelbrot, L, Estellat, C, Sauvegrain, P, Azria, E, Blondel, B, Bourgeois-Moine, A, Ceccaldi, P, Crenn-Hebert, C, Ducarme, G, Lecler, C, Oury, J, Ravaud, P, Sibiude, J, Anselem, O, Bonnet, M, Cognet, M, Duquesnois, S, Guedj, R, Ngo, C, Richetin, J, Rousseau, A, Saurel, M, Linard M., Deneux-Tharaux C., Luton D., Schmitz T., Mandelbrot L., Estellat C., Sauvegrain P., Azria E., Blondel B., Bourgeois-Moine A., Ceccaldi P. F., Crenn-Hebert C., Ducarme G., Lecler C., Oury J. -F., Ravaud P., Sibiude J., Anselem O., Bonnet M. -P., Cognet M., Duquesnois S., Guedj R., Ngo C., Richetin J., Rousseau A., Saurel M. -J., Linard, M, Deneux-Tharaux, C, Luton, D, Schmitz, T, Mandelbrot, L, Estellat, C, Sauvegrain, P, Azria, E, Blondel, B, Bourgeois-Moine, A, Ceccaldi, P, Crenn-Hebert, C, Ducarme, G, Lecler, C, Oury, J, Ravaud, P, Sibiude, J, Anselem, O, Bonnet, M, Cognet, M, Duquesnois, S, Guedj, R, Ngo, C, Richetin, J, Rousseau, A, Saurel, M, Linard M., Deneux-Tharaux C., Luton D., Schmitz T., Mandelbrot L., Estellat C., Sauvegrain P., Azria E., Blondel B., Bourgeois-Moine A., Ceccaldi P. F., Crenn-Hebert C., Ducarme G., Lecler C., Oury J. -F., Ravaud P., Sibiude J., Anselem O., Bonnet M. -P., Cognet M., Duquesnois S., Guedj R., Ngo C., Richetin J., Rousseau A., and Saurel M. -J.

Abstract

Background: In many Western countries, higher rates of cesarean have been described among migrant women compared to natives of receiving countries. We aimed to estimate this difference comparing women originating from France and Sub-Saharan Africa (SSA), identify the clinical situations explaining most of this difference and assess whether maternal origin was independently associated with cesarean risk. Methods: The PreCARE prospective multicenter cohort study was conducted in 2010-2012 in the north Paris area. Our sample was restricted to 1500 women originating from Sub-Saharan Africa and 2206 from France. Profiles of cesarean section by maternal origin were described by the Robson classification. Independent associations between maternal origin and 1) cesarean before labor versus trial of labor, then 2) intrapartum cesarean versus vaginal delivery were assessed by logistic regression models to adjust for other maternal and pregnancy characteristics. Results: Rates of cesarean for women originating from France and SSA were 17 and 31%. The Robson 5A category "unique uterine scar, single cephalic ≥37 weeks" was the main contributor to this difference. Within this category, SSA origin was associated with cesarean before labor after adjustment for medical risk factors (adjusted odds ratio [aOR] = 2.30 [1.12-4.71]) but no more significant when adjusting on social deprivation (aOR = 1.45 [0.63-3.31]). SSA origin was associated with cesarean during labor after adjustment for both medical and social factors (aOR = 2.95 [1.35-6.44]). Conclusions: The wide difference in cesarean rates between SSA and French native women is mainly explained by the Robson 5A category. Within this group, medical factors alone do not explain the increased risk of cesarean in SSA women.

Published
2019

40. Differential rates of cesarean delivery by maternal geographical origin: a cohort study in France

Author

Linard M., Deneux-Tharaux C., Luton D., Schmitz T., Mandelbrot L., Estellat C., Sauvegrain P., Azria E., Blondel B., Bourgeois-Moine A., Ceccaldi P. F., Crenn-Hebert C., Ducarme G., Lecler C., Oury J. -F., Ravaud P., Sibiude J., Anselem O., Bonnet M. -P., Cognet M., Duquesnois S., Guedj R., Ngo C., Richetin J., Rousseau A., Saurel M. -J., Linard, M, Deneux-Tharaux, C, Luton, D, Schmitz, T, Mandelbrot, L, Estellat, C, Sauvegrain, P, Azria, E, Blondel, B, Bourgeois-Moine, A, Ceccaldi, P, Crenn-Hebert, C, Ducarme, G, Lecler, C, Oury, J, Ravaud, P, Sibiude, J, Anselem, O, Bonnet, M, Cognet, M, Duquesnois, S, Guedj, R, Ngo, C, Richetin, J, Rousseau, A, Saurel, M, Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique (CRESS - U1153), Université Paris Descartes - Paris 5 (UPD5)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Descartes - Paris 5 (UPD5), CIC - CHU Bichat, Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Diderot - Paris 7 (UPD7), AP-HP Hôpital universitaire Robert-Debré [Paris], Hopital Louis Mourier - AP-HP [Colombes], Epidémiologie Clinique et Evaluation Economique Appliquées aux Populations Vulnérables (ECEVE (U1123 / UMR_S_1123)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AP-HP Hôpital universitaire Robert-Debré [Paris], CHU Pitié-Salpêtrière [APHP], Service de Biostatistique Santé Publique et Information Médicale [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Louis Mourier - AP-HP [Colombes], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Département de Biostatistique, Santé Publique et Information Médicale [CHU Pitié-Salpêtrière] (BIOSPIM ), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Gestionnaire, Hal Sorbonne Université, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)

Subjects
Adult, Logistic Model, [SDV]Life Sciences [q-bio], [SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics, Risk Factors, Pregnancy, Differential care, Odds Ratio, Humans, Prospective Studies, reproductive and urinary physiology, Africa South of the Sahara, Transients and Migrants, Health disparitie, Labor, Obstetric, Sub-Saharan Africa, Cesarean Section, Risk Factor, Parturition, Cesarean delivery, Robson classification, Maternal geographical origin, [SDV] Life Sciences [q-bio], [SDV.MHEP.GEO] Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics, Prospective Studie, Logistic Models, Female, France, Health disparities, Research Article, Human
Abstract

Background In many Western countries, higher rates of cesarean have been described among migrant women compared to natives of receiving countries. We aimed to estimate this difference comparing women originating from France and Sub-Saharan Africa (SSA), identify the clinical situations explaining most of this difference and assess whether maternal origin was independently associated with cesarean risk. Methods The PreCARE prospective multicenter cohort study was conducted in 2010–2012 in the north Paris area. Our sample was restricted to 1500 women originating from Sub-Saharan Africa and 2206 from France. Profiles of cesarean section by maternal origin were described by the Robson classification. Independent associations between maternal origin and 1) cesarean before labor versus trial of labor, then 2) intrapartum cesarean versus vaginal delivery were assessed by logistic regression models to adjust for other maternal and pregnancy characteristics. Results Rates of cesarean for women originating from France and SSA were 17 and 31%. The Robson 5A category “unique uterine scar, single cephalic ≥37 weeks” was the main contributor to this difference. Within this category, SSA origin was associated with cesarean before labor after adjustment for medical risk factors (adjusted odds ratio [aOR] = 2.30 [1.12–4.71]) but no more significant when adjusting on social deprivation (aOR = 1.45 [0.63–3.31]). SSA origin was associated with cesarean during labor after adjustment for both medical and social factors (aOR = 2.95 [1.35–6.44]). Conclusions The wide difference in cesarean rates between SSA and French native women is mainly explained by the Robson 5A category. Within this group, medical factors alone do not explain the increased risk of cesarean in SSA women. Electronic supplementary material The online version of this article (10.1186/s12884-019-2364-x) contains supplementary material, which is available to authorized users.

Published
2019

45. Liste des collaborateurs

Author

Almange, C., primary, Andrès, P., additional, Arcangeli-Belgy, M.-T., additional, Artus, M., additional, Assari, F., additional, Bacq, Y., additional, Bader, G., additional, Balouet, P., additional, Baraille, A., additional, Bardin-Bedu, C., additional, Beillat, T., additional, Benoist, G., additional, Beucher, G., additional, Blanchère, J.-P., additional, Blot, P., additional, Boog, G., additional, Boulogne, A.-I., additional, Brasseur, G., additional, Buzenet, C., additional, Cabrol, D., additional, Carbonne, B., additional, Carbonneaux, S., additional, Carles, G., additional, Carluer, L., additional, Chabrolle, J.-P., additional, Coffin, C., additional, Cournot, M.-P., additional, Cuvelier, A., additional, d'Ercole, C., additional, Dallay, D., additional, Dao, T., additional, Dayan, J., additional, de Guerke, L., additional, Dejean, A., additional, Delcroix, M., additional, Deschamps, A., additional, Desprats, R., additional, Diguet, A., additional, Dompmartin, A., additional, Doyen, C., additional, Dran, C., additional, Dreyfus, M., additional, Dupuis, O., additional, Durier, M., additional, Elefant, E., additional, Evain-Brion, D., additional, Faury, M.-N., additional, Forgeard, C., additional, Fournet, P., additional, Fournier, T., additional, Gabriel, R., additional, Galley-Raulin, F., additional, Galliot, L., additional, Gaucherand, P., additional, Giami, I., additional, Goffinet, F., additional, Golfier, F., additional, Gomez, C., additional, Gondry, J., additional, Gouyon, J.-B., additional, Grossetti, E., additional, Grout, M.-A., additional, Grynberg, M., additional, Guillaume, S., additional, Harvey, T., additional, Hebert, A., additional, Hillion, K., additional, Himily, V., additional, Houet-Zuccalli, T., additional, Houssin, I., additional, Kakol, M., additional, Langer, B., additional, Lansac, J., additional, Lanta, S., additional, Lavaud, M., additional, Le Querrec, A., additional, Lecointe-Jolly, V., additional, Lejeune, V., additional, Lemery, D., additional, Lepercq, J., additional, Leroy, S., additional, Lestang, I., additional, Longépé, J., additional, Lo Presti, J.-P., additional, Mahieu-Caputo, D., additional, Maillet, R., additional, Malassiné, A., additional, Mandelbrot, L., additional, Marpeau, L., additional, Marpeau-Delignière, P., additional, Marret, S., additional, Martin, S., additional, Massardier, J., additional, Mercier, C., additional, Moreau, Y., additional, Morin, C., additional, Muir, J.-F., additional, Nguyen, F., additional, Nivot-Roman, E., additional, Nizard, J., additional, Oury, J.-F., additional, Pajot-Pharose, E., additional, Parant, O., additional, Paris, F., additional, Polzin, K., additional, Provost, D., additional, Radi, S., additional, Renner, J.-P., additional, Reman, O., additional, Revaux, A., additional, Ricbourg, A., additional, Riethmuller, D., additional, Rivière, M., additional, Roman, H., additional, Rotten, D., additional, Rozenberg, P., additional, Schaal, J.-P., additional, Schnitzler, K., additional, Sentilhes, L., additional, Sergent, F., additional, Siegler, L., additional, Simon, A., additional, Simon-Toulza, C., additional, Sutter-Dallay, A.-L., additional, Szymansky, N., additional, Teurnier, F., additional, Trichot, C., additional, Tsatsaris, V., additional, Vallée, M.-M., additional, Vauzelle, C., additional, Venditelli, F., additional, Vercoustre, L., additional, Vérot, C., additional, Verspyck, E., additional, Viader, F., additional, Winer, N., additional, and Zanardi, M., additional

Published
2010
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48. Prenatal description of retinal coloboma

Author

Egloff, C., primary, Tassin, M., additional, Bault, J.P., additional, Barjol, A., additional, Collin, A., additional, Simon, I., additional, Sibiude, J., additional, Mandelbrot, L., additional, and Picone, O., additional

Published
2020
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49. Recommandations pour la pratique clinique : grossesses après chirurgie bariatrique – Groupe BARIA-MAT

Author

Gascoin, G., primary, Ciangura, C., additional, Canale, C., additional, Castera, V., additional, Coupaye, M., additional, Coutant, R., additional, Deruelle, P., additional, Dupré, T., additional, Gascoin, G., additional, Calabrese, D., additional, Cosson, E., additional, Ducarme, G., additional, Gaborit, B., additional, Joly, A.S., additional, Johanet, H., additional, Lelièvre, B., additional, Mandelbrot, L., additional, Petrucciani, N., additional, Pigeyre, M., additional, Quilliot, D., additional, Ritz, P., additional, Robin, G., additional, Rochereau, B., additional, Sallé, A., additional, Taillard, V., additional, Gugenheim, J., additional, and Nizard, J., additional

Published
2019
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