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2. Digital biomarkers and artificial intelligence for mass diagnosis of atrial fibrillation in a population sample at risk of sleep disordered breathing

Author

Chocron, Armand, Efraim, Roi, Mandel, Franck, Rueschman, Michael, Palmius, Niclas, Penzel, Thomas, Elbaz, Meyer, and Behar, Joachim A.

Subjects
Electrical Engineering and Systems Science - Signal Processing
Abstract

Atrial fibrillation (AF) is the most prevalent arrhythmia and is associated with a five-fold increase in stroke risk. Many individuals with AF go undetected. These individuals are often asymptomatic. There are ongoing debates on whether mass screening for AF is to be recommended. However, there is incentive in performing screening for specific at risk groups such as individuals suspected of sleep-disordered breathing where an important association between AF and obstructive sleep apnea (OSA) has been demonstrated. We introduce a new methodology leveraging digital biomarkers and recent advances in artificial intelligence (AI) for the purpose of mass AF diagnosis. We demonstrate the value of such methodology in a large population sample at risk of sleep disordered breathing. Four databases, totaling n=3,088 patients and p=26,913 hours of ECG raw data were used. Three of the databases (n=125, p=2,513) were used for training a machine learning model in recognizing AF events from beat-to-beat interval time series. The visit 1 of the sleep heart health study database (SHHS1, n=2,963, p=24,400) consists of overnight polysomnographic (PSG) recordings, and was considered as the test set. In SHHS1, expert inspection identified a total of 70 patients with a prominent AF rhythm. Model prediction on the SHHS1 showed an overall Se=0.97,Sp=0.99,NPV=0.99,PPV=0.67 in classifying individuals with or without prominent AF. PPV was non-inferior (p=0.03) for individuals with an apnea-hypopnea index (AHI) > 15 versus AHI < 15. Over 22% of correctly identified prominent AF rhythm cases were not documented as AF in the SHHS1. Individuals with prominent AF can be automatically diagnosed from an overnight single channel ECG recording, with an accuracy unaffected by the presence of OSA. AF detection from overnight ECG recording revealed a large proportion of undiagnosed AF and may enhance the phenotyping of OSA.

Published
2020
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4. Sex Differences in Outcomes of Tetralogy of Fallot Patients With Implantable Cardioverter-Defibrillators

Author

Akret, Chrystelle, Albenque, Jean-Paul, Algalarrondo, Vincent, Alonso, Christine, Amet, Denis, Ansselme, Frédéric, Asselin, Anouk, Audinet, Caroline, Badenco, Nicolas, Bader, Hugues, Badoz, Marc, Baudinaud, Pierre, Behar, Nathalie, Ben Kilani, Mouna, Bernard, Yvette, Bertaux, Géraldine, Bertrand, Cathy, Bessiere, Francis, Blangy, Hughes, Bonnet, Damien, Bordchar, Pierre, Bouzeman, Abdeslam, Boveda, Serge, Bru, Paul, Bun, Sok Sithikun, Carabelli, Adrien, Cardin, Christèle, Cauchemez, Bruno, Chalbia, Tej, Champ-Rigot, Laure, Chastre, Thomas, Chevallier, Philippe, Clementy, Nicolas, Clerici, Gaël, Combes, Nicolas, Combes, Stéphane, Da Costa, Antoine, De Chillou, Christian, De Guillebon, Maxime, Defaye, Pascal, Degand, Bruno, Deharo, Jean-Claude, Derval, Nicolas, Di Filippo, Sylvie, Domain, Guillaume, Dompnier, Antoine, Dulac, Arnaud, Duparc, Alexandre, Duplantier, D Cécile, Duthoit, Guillaume, El Bouazzaoui, Rim, Elbaz, Nathalie, Enache, Bogdan, Eschalier, Romain, Extramiana, Fabrice, Fauchier, Laurent, Fiorello, Pierre, Frey, Pierre, Freysz, Luc, Galand, Vincent, Gandjbakhch, Estelle, Garcia, Rodrigue, Gardey, Kevin, Geoffroy, Olivier, Godin, Bénédicte, Gourraud, Jean-Baptiste, Goussot, Samuel, Grimard, Caroline, Guenancia, Charles, Guichard, Jean-Baptiste, Guy-Moyat, Benoit, Haissaguerre, Michel, Halimi, Franck, Hamon, David, Hascoet, Sébastien, Hasni, Karim, Hermida, Alexis, Hermida, Jean-Sylvain, Hidden-Lucet, Françoise, Hocini, Mélèze, Hourdain, Jérome, Irles, Didier, Iserin, Laurence, Jacon, Peggy, Jauvert, Gaël, Jean, Frédéric, Johnson, Nicolas, Jourda, François, Khattar, Pierre, Khoueiry, Ziad, Koutbi, Rita, Labombarda, Fabien, Laborie, Guillaume, Lactu, Gabriel, Ladouceur, Magalie, Lagrange, Philippe, Lallemand, Pierre-Marc, Laredo, Mikael, Laurent, Gabriel, Lavergne, Thomas, Lazarus, Arnaud, Le Gloan, Laurianne, Leclercq, Christophe, Leenhardt, Antoine, Lellouche, Nicolas, Loose, Christophe, Mabo, Philippe, Maltret, Alice, Mandel, Franck, Mansourati, Jacques, Marijon, Eloi, Marquie, Christelle, Martins, Raphaël, Mathiron, Amel, Maupain, Carole, Maury, Philippe, Messali, Anne, Milhelm, Antoine, Milliez, Paul, Mirolo, Adrian, Mondoly, Pierre, Moubarak, Ghassan, Mourot, Stéphane, Nguyen, Cédric, Ollitrault, Jacky, Ollitrault, Pierre, Otmani, Akli, Pasquie, Jean-Luc, Pavin, Dominique, Perier, Marie-Cécile, Philibert, Séverinne, Poindron, Damien, Potelle, Charlotte, Probst, Vincent, Puie, Paul, Pujadas, Penelope, Rollin, Anne, Romeyer-Bouchard, Cécile, Sacher, Frédéric, Sadoul, Nicolas, Sagnard, Audrey, Sagnol, Pascal, Savoure, Arnaud, Scarlatti, Didier, Sellal, Jean Marc, Sharifzadehgan, Ardalan, Squara, Fabien, Tanese, Nikita, Thambo, Jean Benoit, Thomas, Olivier, Varlet, Emie, Venier, Sandrine, Stephanopoli, Quentin Voglimacci, Waintraub, Xavier, Waldmann, Victor, Walton, Camille, Wiart, Françoise, Winum, Pierre, Zakine, Cyril, Zhao, Alexandre, Zouaghi, Amir, Koutbi, Linda, Bessière, Francis, Marquié, Christelle, Bordachar, Pierre, Al Arnaout, Alain, Anselme, Frédéric, Chassignolle, Morgane, de Guillebon, Maxime, Massoulié, Grégoire, Narayanan, Kumar, Ninni, Sandro, Pierre, Bertrand, Pasquié, Jean-Luc, Thambo, Jean-Benoit, and Jouven, Xavier

Published
2022
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9. A worldwide survey on incidence, management and prognosis of oesophageal fistula formation following atrial fibrillation catheter ablation: The POTTER-AF study

Author

Tilz, Roland Richard, Schmidt, Vanessa, Pürerfellner, Helmut, Maury, Philippe, Chun, Kr Julian, Martinek, Martin, Sohns, Christian, Schmidt, Boris, Mandel, Franck, Gandjbakhch, Estelle, Laredo, Mikael, Gunawardene, Melanie Anuscha, Willems, Stephan, Beiert, Thomas, Borlich, Martin, Iden, Leon, Füting, Anna, Spittler, Raphael, Gaspar, Thomas, Richter, Sergio, Schade, Anja, Kuniss, Malte, Neumann, Thomas, Francke, Alexander, Wunderlich, Carsten, Shin, Dong-In, Grosse Meininghaus, Dirk, Foresti, Mike, Bonsels, Marc, Reek, David, Wiegand, Uwe, Bauer, Alexander, Metzner, Andreas, Eckardt, Lars, Popescu, Sorin Ștefan, Krahnefeld, Olaf, Sticherling, Christian, Kühne, Michael, Nguyen, Dinh Quang, Roten, Laurent, Saguner, Ardan M, Linz, Dominik, van der Voort, Pepijn, Mulder, Bart A, Vijgen, Johan, Almorad, Alexandre, Guenancia, Charles, Fauchier, Laurent, Boveda, Serge, De Greef, Y, Da Costa, Antoine, Jais, Pierre, Derval, Nicolas, Milhem, Antoine, Jesel, Laurence, Garcia, Rodrigue, Poty, Hervé, Khoueiry, Ziad, Seitz, Julien, Laborderie, Julien, Mechulan, Alexis, Brigadeau, Francois, Zhao, Alexandre, Saludas, Yannick, Piot, Olivier, Ahluwalia, Nikhil, Martin, Claire, Chen, Jian, Antolic, Bor, Leventopoulos, Georgios, Özcan, Emin Evren, Yorgun, Hikmet, Cay, Serkan, Yalin, Kivanc, Botros, Maichel Sobhy, Mahmoud, Ahmed Taher, Jędrzejczyk-Patej, Ewa, Inaba, Osamu, Okumura, Ken, Ejima, Koichiro, Khakpour, Houman, Boyle, Noel, Catanzaro, J N, Reddy, Vivek, Mohanty, Sanghamitra, Natale, Andrea, Blessberger, Hermann, Yang, Bing, Stevens, Irene, Sommer, Philipp, Veltmann, Christian, Steven, Daniel, Vogler, Julia, Kuck, Karl-Heinz, Merino, José Luis, Keelani, Ahmad, and Heeger, Christian-H

Subjects
610 Medicine & health, ddc:610, Cardiology and Cardiovascular Medicine
Abstract

Aims Oesophageal fistula represents a rare but dreadful complication of atrial fibrillation catheter ablation. Data on its incidence, management, and outcome are sparse. Methods and results This international multicentre registry investigates the characteristics of oesophageal fistulae after treatment of atrial fibrillation by catheter ablation. A total of 553 729 catheter ablation procedures (radiofrequency: 62.9%, cryoballoon: 36.2%, other modalities: 0.9%) were performed, at 214 centres in 35 countries. In 78 centres 138 patients [0.025%, radiofrequency: 0.038%, cryoballoon: 0.0015% (P < 0.0001)] were diagnosed with an oesophageal fistula. Peri-procedural data were available for 118 patients (85.5%). Following catheter ablation, the median time to symptoms and the median time to diagnosis were 18 (7.75, 25; range: 0–60) days and 21 (15, 29.5; range: 2–63) days, respectively. The median time from symptom onset to oesophageal fistula diagnosis was 3 (1, 9; range: 0–42) days. The most common initial symptom was fever (59.3%). The diagnosis was established by chest computed tomography in 80.2% of patients. Oesophageal surgery was performed in 47.4% and direct endoscopic treatment in 19.8% and conservative treatment in 32.8% of patients. The overall mortality was 65.8%. Mortality following surgical (51.9%) or endoscopic treatment (56.5%) was significantly lower as compared to conservative management (89.5%) [odds ratio 7.463 (2.414, 23.072) P < 0.001]. Conclusion Oesophageal fistula after catheter ablation of atrial fibrillation is rare and occurs mostly with the use of radiofrequency energy rather than cryoenergy. Mortality without surgical or endoscopic intervention is exceedingly high.

Published
2023

10. Hemodynamical consequences and tolerance of sustained ventricular tachycardia

Author

Delasnerie, Hubert, primary, Biendel, Caroline, additional, Elbaz, Meyer, additional, Mandel, Franck, additional, Beneyto, Maxime, additional, Domain, Guillaume, additional, Voglimacci-Stephanopoli, Quentin, additional, Mondoly, Pierre, additional, Delmas, Clement, additional, Bongard, Vanina, additional, Rollin, Anne, additional, and Maury, Philippe, additional

Published
2023
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11. A worldwide survey on incidence, management, and prognosis of oesophageal fistula formation following atrial fibrillation catheter ablation: the POTTER-AF study

Author

Tilz, Roland Richard, primary, Schmidt, Vanessa, additional, Pürerfellner, Helmut, additional, Maury, Philippe, additional, Chun, K R J ulian, additional, Martinek, Martin, additional, Sohns, Christian, additional, Schmidt, Boris, additional, Mandel, Franck, additional, Gandjbakhch, Estelle, additional, Laredo, Mikael, additional, Gunawardene, Melanie Anuscha, additional, Willems, Stephan, additional, Beiert, Thomas, additional, Borlich, Martin, additional, Iden, Leon, additional, Füting, Anna, additional, Spittler, Raphael, additional, Gaspar, Thomas, additional, Richter, Sergio, additional, Schade, Anja, additional, Kuniss, Malte, additional, Neumann, Thomas, additional, Francke, Alexander, additional, Wunderlich, Carsten, additional, Shin, Dong-In, additional, Meininghaus, Dirk Grosse, additional, Foresti, Mike, additional, Bonsels, Marc, additional, Reek, David, additional, Wiegand, Uwe, additional, Bauer, Alexander, additional, Metzner, Andreas, additional, Eckardt, Lars, additional, Popescu, Sorin Ștefan, additional, Krahnefeld, Olaf, additional, Sticherling, Christian, additional, Kühne, Michael, additional, Nguyen, Dinh Quang, additional, Roten, Laurent, additional, Saguner, Ardan M, additional, Linz, Dominik, additional, van der Voort, Pepijn, additional, Mulder, Bart A, additional, Vijgen, Johan, additional, Almorad, Alexandre, additional, Guenancia, Charles, additional, Fauchier, Laurent, additional, Boveda, Serge, additional, Greef, Y De, additional, Da Costa, Antoine, additional, Jais, Pierre, additional, Derval, Nicolas, additional, Milhem, Antoine, additional, Jesel, Laurence, additional, Garcia, Rodrigue, additional, Poty, Hervé, additional, Khoueiry, Ziad, additional, Seitz, Julien, additional, Laborderie, Julien, additional, Mechulan, Alexis, additional, Brigadeau, Francois, additional, Zhao, Alexandre, additional, Saludas, Yannick, additional, Piot, Olivier, additional, Ahluwalia, Nikhil, additional, Martin, Claire, additional, Chen, Jian, additional, Antolic, Bor, additional, Leventopoulos, Georgios, additional, Özcan, Emin Evren, additional, Yorgun, Hikmet, additional, Cay, Serkan, additional, Yalin, Kivanc, additional, Botros, Maichel Sobhy, additional, Mahmoud, Ahmed Taher, additional, Jędrzejczyk-Patej, Ewa, additional, Inaba, Osamu, additional, Okumura, Ken, additional, Ejima, Koichiro, additional, Khakpour, Houman, additional, Boyle, Noel, additional, Catanzaro, John N, additional, Reddy, Vivek, additional, Mohanty, Sanghamitra, additional, Natale, Andrea, additional, Blessberger, Hermann, additional, Yang, Bing, additional, Stevens, Irene, additional, Sommer, Philipp, additional, Veltmann, Christian, additional, Steven, Daniel, additional, Vogler, Julia, additional, Kuck, Karl-Heinz, additional, Merino, José Luis, additional, Keelani, Ahmad, additional, and Heeger, Christian-H, additional

Published
2023
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14. Correlations Between Endocardial Voltage Mapping, Diagnosis, and Genetics in Patients With Arrhythmogenic Right Ventricular Cardiomyopathy

Author

Delasnerie, Hubert, primary, Gandjbakhch, Estelle, additional, Sauve, Romain, additional, Beneyto, Maxime, additional, Domain, Guillaume, additional, Voglimacci-Stephanopoli, Quentin, additional, Mandel, Franck, additional, Badenco, Nicolas, additional, Waintraub, Xavier, additional, Mondoly, Pierre, additional, Fressart, Véronique, additional, Rollin, Anne, additional, and Maury, Philippe, additional

Published
2023
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15. A worldwide survey on incidence, management, and prognosis of oesophageal fistula formation following atrial fibrillation catheter ablation: the POTTER-AF study

Author

Tilz, Roland Richard; https://orcid.org/0000-0002-0122-7130, Schmidt, Vanessa, Pürerfellner, Helmut, Maury, Philippe; https://orcid.org/0000-0002-4800-1841, Chun, K R Julian, Martinek, Martin; https://orcid.org/0000-0002-8895-8488, Sohns, Christian; https://orcid.org/0000-0003-0490-5862, Schmidt, Boris; https://orcid.org/0000-0001-5347-9906, Mandel, Franck, Gandjbakhch, Estelle; https://orcid.org/0000-0002-4846-5021, Laredo, Mikael; https://orcid.org/0000-0002-7326-2656, Gunawardene, Melanie Anuscha, Willems, Stephan; https://orcid.org/0000-0002-8890-5749, Beiert, Thomas, Borlich, Martin, Iden, Leon, Füting, Anna, Spittler, Raphael, Gaspar, Thomas, Richter, Sergio, Schade, Anja, Kuniss, Malte; https://orcid.org/0000-0002-1593-9657, Neumann, Thomas, Francke, Alexander, Wunderlich, Carsten, Shin, Dong-In, Meininghaus, Dirk Grosse; https://orcid.org/0000-0003-1532-1934, Foresti, Mike, Bonsels, Marc, Reek, David, et al, Saguner, Ardan M; https://orcid.org/0000-0003-1896-0803, Tilz, Roland Richard; https://orcid.org/0000-0002-0122-7130, Schmidt, Vanessa, Pürerfellner, Helmut, Maury, Philippe; https://orcid.org/0000-0002-4800-1841, Chun, K R Julian, Martinek, Martin; https://orcid.org/0000-0002-8895-8488, Sohns, Christian; https://orcid.org/0000-0003-0490-5862, Schmidt, Boris; https://orcid.org/0000-0001-5347-9906, Mandel, Franck, Gandjbakhch, Estelle; https://orcid.org/0000-0002-4846-5021, Laredo, Mikael; https://orcid.org/0000-0002-7326-2656, Gunawardene, Melanie Anuscha, Willems, Stephan; https://orcid.org/0000-0002-8890-5749, Beiert, Thomas, Borlich, Martin, Iden, Leon, Füting, Anna, Spittler, Raphael, Gaspar, Thomas, Richter, Sergio, Schade, Anja, Kuniss, Malte; https://orcid.org/0000-0002-1593-9657, Neumann, Thomas, Francke, Alexander, Wunderlich, Carsten, Shin, Dong-In, Meininghaus, Dirk Grosse; https://orcid.org/0000-0003-1532-1934, Foresti, Mike, Bonsels, Marc, Reek, David, et al, and Saguner, Ardan M; https://orcid.org/0000-0003-1896-0803

Abstract

AIMS Oesophageal fistula represents a rare but dreadful complication of atrial fibrillation catheter ablation. Data on its incidence, management, and outcome are sparse. METHODS AND RESULTS This international multicentre registry investigates the characteristics of oesophageal fistulae after treatment of atrial fibrillation by catheter ablation. A total of 553 729 catheter ablation procedures (radiofrequency: 62.9%, cryoballoon: 36.2%, other modalities: 0.9%) were performed, at 214 centres in 35 countries. In 78 centres 138 patients [0.025%, radiofrequency: 0.038%, cryoballoon: 0.0015% (P < 0.0001)] were diagnosed with an oesophageal fistula. Peri-procedural data were available for 118 patients (85.5%). Following catheter ablation, the median time to symptoms and the median time to diagnosis were 18 (7.75, 25; range: 0-60) days and 21 (15, 29.5; range: 2-63) days, respectively. The median time from symptom onset to oesophageal fistula diagnosis was 3 (1, 9; range: 0-42) days. The most common initial symptom was fever (59.3%). The diagnosis was established by chest computed tomography in 80.2% of patients. Oesophageal surgery was performed in 47.4% and direct endoscopic treatment in 19.8% and conservative treatment in 32.8% of patients. The overall mortality was 65.8%. Mortality following surgical (51.9%) or endoscopic treatment (56.5%) was significantly lower as compared to conservative management (89.5%) [odds ratio 7.463 (2.414, 23.072) P < 0.001]. CONCLUSION Oesophageal fistula after catheter ablation of atrial fibrillation is rare and occurs mostly with the use of radiofrequency energy rather than cryoenergy. Mortality without surgical or endoscopic intervention is exceedingly high.

Published
2023

17. Sex Differences in Outcomes of Tetralogy of Fallot Patients With Implantable Cardioverter-Defibrillators

Author

Waldmann, Victor, primary, Bouzeman, Abdeslam, additional, Duthoit, Guillaume, additional, Koutbi, Linda, additional, Bessière, Francis, additional, Labombarda, Fabien, additional, Marquié, Christelle, additional, Gourraud, Jean-Baptiste, additional, Mondoly, Pierre, additional, Sellal, Jean Marc, additional, Bordachar, Pierre, additional, Hermida, Alexis, additional, Al Arnaout, Alain, additional, Anselme, Frédéric, additional, Audinet, Caroline, additional, Bernard, Yvette, additional, Boveda, Serge, additional, Bun, Sok Sithikun, additional, Chassignolle, Morgane, additional, Clerici, Gaël, additional, Da Costa, Antoine, additional, de Guillebon, Maxime, additional, Defaye, Pascal, additional, Elbaz, Nathalie, additional, Eschalier, Romain, additional, Garcia, Rodrigue, additional, Guenancia, Charles, additional, Guy-Moyat, Benoit, additional, Halimi, Franck, additional, Irles, Didier, additional, Iserin, Laurence, additional, Jourda, François, additional, Ladouceur, Magalie, additional, Lagrange, Philippe, additional, Laredo, Mikael, additional, Mansourati, Jacques, additional, Massoulié, Grégoire, additional, Mathiron, Amel, additional, Maury, Philippe, additional, Messali, Anne, additional, Narayanan, Kumar, additional, Nguyen, Cédric, additional, Ninni, Sandro, additional, Perier, Marie-Cécile, additional, Pierre, Bertrand, additional, Pujadas, Penelope, additional, Sacher, Frédéric, additional, Sagnol, Pascal, additional, Sharifzadehgan, Ardalan, additional, Walton, Camille, additional, Winum, Pierre, additional, Zakine, Cyril, additional, Fauchier, Laurent, additional, Martins, Raphaël, additional, Pasquié, Jean-Luc, additional, Thambo, Jean-Benoit, additional, Jouven, Xavier, additional, Combes, Nicolas, additional, Marijon, Eloi, additional, Akret, Chrystelle, additional, Albenque, Jean-Paul, additional, Algalarrondo, Vincent, additional, Alonso, Christine, additional, Amet, Denis, additional, Ansselme, Frédéric, additional, Asselin, Anouk, additional, Badenco, Nicolas, additional, Bader, Hugues, additional, Badoz, Marc, additional, Baudinaud, Pierre, additional, Behar, Nathalie, additional, Ben Kilani, Mouna, additional, Bertaux, Géraldine, additional, Bertrand, Cathy, additional, Bessiere, Francis, additional, Blangy, Hughes, additional, Bonnet, Damien, additional, Bordchar, Pierre, additional, Bru, Paul, additional, Carabelli, Adrien, additional, Cardin, Christèle, additional, Cauchemez, Bruno, additional, Chalbia, Tej, additional, Champ-Rigot, Laure, additional, Chastre, Thomas, additional, Chevallier, Philippe, additional, Clementy, Nicolas, additional, Combes, Stéphane, additional, De Chillou, Christian, additional, De Guillebon, Maxime, additional, Degand, Bruno, additional, Deharo, Jean-Claude, additional, Derval, Nicolas, additional, Di Filippo, Sylvie, additional, Domain, Guillaume, additional, Dompnier, Antoine, additional, Dulac, Arnaud, additional, Duparc, Alexandre, additional, Duplantier, D Cécile, additional, El Bouazzaoui, Rim, additional, Enache, Bogdan, additional, Extramiana, Fabrice, additional, Fiorello, Pierre, additional, Frey, Pierre, additional, Freysz, Luc, additional, Galand, Vincent, additional, Gandjbakhch, Estelle, additional, Gardey, Kevin, additional, Geoffroy, Olivier, additional, Godin, Bénédicte, additional, Goussot, Samuel, additional, Grimard, Caroline, additional, Guichard, Jean-Baptiste, additional, Haissaguerre, Michel, additional, Hamon, David, additional, Hascoet, Sébastien, additional, Hasni, Karim, additional, Hermida, Jean-Sylvain, additional, Hidden-Lucet, Françoise, additional, Hocini, Mélèze, additional, Hourdain, Jérome, additional, Jacon, Peggy, additional, Jauvert, Gaël, additional, Jean, Frédéric, additional, Johnson, Nicolas, additional, Khattar, Pierre, additional, Khoueiry, Ziad, additional, Koutbi, Rita, additional, Laborie, Guillaume, additional, Lactu, Gabriel, additional, Lallemand, Pierre-Marc, additional, Laurent, Gabriel, additional, Lavergne, Thomas, additional, Lazarus, Arnaud, additional, Le Gloan, Laurianne, additional, Leclercq, Christophe, additional, Leenhardt, Antoine, additional, Lellouche, Nicolas, additional, Loose, Christophe, additional, Mabo, Philippe, additional, Maltret, Alice, additional, Mandel, Franck, additional, Marquie, Christelle, additional, Maupain, Carole, additional, Milhelm, Antoine, additional, Milliez, Paul, additional, Mirolo, Adrian, additional, Moubarak, Ghassan, additional, Mourot, Stéphane, additional, Ollitrault, Jacky, additional, Ollitrault, Pierre, additional, Otmani, Akli, additional, Pasquie, Jean-Luc, additional, Pavin, Dominique, additional, Philibert, Séverinne, additional, Poindron, Damien, additional, Potelle, Charlotte, additional, Probst, Vincent, additional, Puie, Paul, additional, Rollin, Anne, additional, Romeyer-Bouchard, Cécile, additional, Sadoul, Nicolas, additional, Sagnard, Audrey, additional, Savoure, Arnaud, additional, Scarlatti, Didier, additional, Squara, Fabien, additional, Tanese, Nikita, additional, Thambo, Jean Benoit, additional, Thomas, Olivier, additional, Varlet, Emie, additional, Venier, Sandrine, additional, Stephanopoli, Quentin Voglimacci, additional, Waintraub, Xavier, additional, Waldmann, Victor, additional, Wiart, Françoise, additional, Zhao, Alexandre, additional, and Zouaghi, Amir, additional

Published
2022
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19. Radiation dose during catheter ablation in children using a low fluoroscopy frame rate

Author

Riche, Maya, primary, Monfraix, Sylvie, additional, Balduyck, Sebastien, additional, Voglimacci-Stephanopoli, Quentin, additional, Rollin, Anne, additional, Mondoly, Pierre, additional, Mandel, Franck, additional, Beneyto, Maxime, additional, Delasnerie, Hubert, additional, Derval, Nicolas, additional, Thambo, Jean Benoit, additional, Karsenty, Clement, additional, Dulac, Yves, additional, Acar, Philippe, additional, Mora, Stéphanie, additional, Gautier, Romain, additional, Sacher, Frederic, additional, and Maury, Philippe, additional

Published
2022
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22. Successful Reversal of Severe Tachycardia-Induced Cardiomyopathy with Cardiogenic Shock by Urgent Rhythm or Rate Control: Only Rhythm and Rate Matter

Author

Volle, Kim, primary, Delmas, Clément, additional, Rollin, Anne, additional, Voglimacci-Stephanopoli, Quentin, additional, Mondoly, Pierre, additional, Cariou, Eve, additional, Mandel, Franck, additional, Delasnerie, Hubert, additional, Beneyto, Maxime, additional, Galinier, Michel, additional, Lavie-Badie, Yoan, additional, Carrié, Didier, additional, Roncalli, Jerôme, additional, Lairez, Olivier, additional, Fournier, Pauline, additional, Biendel, Caroline, additional, and Maury, Philippe, additional

Published
2021
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26. Relation of outcomes to ABC (Atrial Fibrillation Better Care) pathway adherent care in European patients with atrial fibrillation:an analysis from the ESC-EHRA EORP Atrial Fibrillation General Long-Term (AFGen LT) Registry

Author

Cuisset, Thomas, Fauchier, Laurent, Deharo, Pierre, Cohen, Ariel, Waldmann, Victor, Bouzeman, Abdeslam, Duthoit, Guillaume, Koutbi, Linda, Bessiere, Francis, Labombarda, Fabien, Marquié, Christelle, Gourraud, Jean Baptiste, Mondoly, Pierre, Sellal, Jean Marc, Bordachar, Pierre, Hermida, Alexis, Anselme, Frédéric, Asselin, Anouk, Audinet, Caroline, Bernard, Yvette, Boveda, Serge, Bru, Paul, Bun, Sok Sithikun, Clerici, Gael, da Costa, Antoine, de Guillebon, Maxime, Defaye, Pascal, Elbaz, Nathalie, Eschalier, Romain, Garcia, Rodrigue, Guenancia, Charles, Guy-Moyat, Benoit, Halimi, Franck, Irles, Didier, Iserin, Laurence, Jourda, François, Ladouceur, Magalie, Lagrange, Philippe, Laredo, Mikael, Mansourati, Jacques, Massoulié, Grégoire, Mathiron, Amel, Maury, Philippe, Messali, Anne, Narayanan, Kumar, Nguyen, Cédric, Ninni, Sandro, Perier, Marie-Cécile, Pierre, Bertrand, Pujadas, Penelope, Sacher, Frédéric, Sagnol, Pascal, Sharifzadehgan, Ardalan, Walton, Camille, Winum, Pierre, Zakine, Cyril, Martins, Raphael, Pasquié, Jean Luc, Thambo, Jean Benoit, Jouven, Xavier, Combes, Nicolas, Marijon, Eloi, Squara, Fabien, Theodore, Guillaume, Scarlatti, Didier, Hourdain, Jérome, Deharo, Jean-Claude, Ollitrault, Pierre, Milliez, Paul, Champ-Rigot, Laure, Bader, Hugues, Duplantier, Cécile, Milhem, Antoine, Sagnard, Audrey, Bertaux, Géraldine, Laurent, Gabriel, Badoz, Marc, Bortone, Agustin, Laborie, Guillaume, Rollin, Anne, Stephanopoli, Quentin Voglimacci, Mandel, Franck, Duparc, Alexandre, Domain, Guillaume, Albenque, Jean-Paul, Cardin, Christèle, Combes, Stéphane, Tanese, Nikita, Hasni, Karim, Leclercq, Christophe, Galand, Vincent, Pavin, Dominique, Mabo, Philippe, Behar, Nathalie, Clementy, Nicolas, Loose, Christophe, Otmani, Akli, Venier, Sandrine, Carabelli, Adrien, Jacon, Peggy, Kilani, Mouna Ben, Guichard, Jean Bapstist, Romeyer-Bouchard, Cécile, Le Gloan, Laurianne, Probst, Vincent, Freysz, Luc, Blangy, Hugues, Chillou, Christian De, Sadoul, Nicolas, Khattar, Pierre, Potelle, Charlotte, Jean, Frederic, Puie, Paul, Khoueiry, Ziad, Chevallier, Philippe, Dulac, Arnaud, Filippo, Sylvie Di, Gardey, Kevin, Frey, Pierre, Akret, Chrystelle, Dompnier, Antoine, Maupain, Carole, Waintraub, Xavier, Hidden-Lucet, Françoise, Chastre, Thomas, Gandjbakhch, Estelle, Badenco, Nicolas, Extramiana, Fabrice, Leenhardt, Antoine, Zouaghi, Amir, Algalarrondo, Vincent, Amet, Denis, Varlet, Emilie, Chalbia, Tej, Philibert, Séverine, Ollitrault, Jacky, Lavergne, Thomas, Baudinaud, Pierre, Mirolo, Adrian, Savouré, Arnaud, Godin, Bénédicte, Bertrand, Cathy, Fiorello, Pierre, Johnson, Nicolas, Lallemand, Pierre-Marc, Herminda, Alexis, Hermida, Jean-Sylvain, Degand, Bruno, Bouazzaou, Rim El, Mourot, Stéphane, Goussot, Samuel, Jauvert, Gaël, Lazarus, Arnaud, Grimard, Caroline, Alonso, Christine, Zhao, Alexandre, Thomas, Olivier, Cauchemez, Bruno, Moubarak, Ghassan, Lellouche, Nicolas, Hamon, David, Enache, Bogdan, Lactu, Gabriel, Wiart, Françoise, Geoffroy, Olivier, Poindron, Damien, Maltret, Alice, Raimondo, Cristine, Bonnet, Damien, Hascoët, Sébastien, Derval, Nicolas, Haïssaguerre, Michel, Hocini, Mélèze, Proietti, Marco, Lip, Gregory, Laroche, Cécile, Marin, Francisco, Nabauer, Michael, Potpara, Tatjana, Dan, Gheorghe-Andrei, Kalarus, Zbigniew, Tavazzi, Luigi, Maggioni, Aldo Pietro, Boriani, Giuseppe, Hôpital de la Timone [CHU - APHM] (TIMONE), Nutrition, obésité et risque thrombotique (NORT), Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Trousseau [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Éducation Éthique Santé EA 7505 (EES), Université de Tours (UT), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université Paris Cité (UPCité), Paris-Centre de Recherche Cardiovasculaire (PARCC (UMR_S 970/ U970)), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Centre Hospitalier de Versailles André Mignot (CHV), CHU Pitié-Salpêtrière [AP-HP], Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Département de Cardiologie [Hôpital de la Timone - APHM], Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Hôpital Louis Pradel [CHU - HCL], Hospices Civils de Lyon (HCL), Signalisation, électrophysiologie et imagerie des lésions d’ischémie-reperfusion myocardique (SEILIRM), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre hospitalier universitaire de Nantes (CHU Nantes), Service Cardiologie [CHU Toulouse], Pôle Cardiovasculaire et Métabolique [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), IHU-LIRYC, Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux], Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] (CRCTB), Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Amiens-Picardie, Service de cardiologie [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Groupe Hospitalier Bretagne Sud (GHBS), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Clinique Pasteur, Clinique Pasteur [Toulouse], Service de cardiologie, Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Hôpital Pasteur [Nice] (CHU), CHU Saint-Pierre, Università degli Studi di Milano = University of Milan (UNIMI), Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, University of Liverpool, Aalborg University [Denmark] (AAU), EURObservational Research Programme, European Society of Cardiology, Universidad de Murcia, University of Belgrade [Belgrade], Colentina University Hospital, University of Medicine and Pharmacy 'Carol Davila' Bucharest (UMPCD), Silesian Medical University, Katowice, Poland, University Hospital of Ferrara and Maria Cecilia Hospital, Associazione Nazionale Medici Cardiologi Ospedalieri [Firenze] (ANMCO), Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), UCL - SSS/IREC/MONT - Pôle Mont Godinne, and UCL - (MGD) Service de cardiologie

Subjects
medicine.medical_specialty, Acute coronary syndrome, 030204 cardiovascular system & hematology, Lower risk, [SHS]Humanities and Social Sciences, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Physiology (medical), Internal medicine, Thromboembolism, Atrial Fibrillation, Care pathway, Medicine, Humans, 030212 general & internal medicine, Registries, Outcomes • Registry, business.industry, Hazard ratio, Anticoagulants, Integrated care, Atrial fibrillation, medicine.disease, Confidence interval, 3. Good health, Stroke, Cohort, Cardiology and Cardiovascular Medicine, business
Abstract

Aims There has been an increasing focus on integrated, multidisciplinary, and holistic care in the treatment of atrial fibrillation (AF). The ‘Atrial Fibrillation Better Care’ (ABC) pathway has been proposed to streamline integrated care in AF. We evaluated the impact on outcomes of an ABC adherent management in a contemporary real-life European-wide AF cohort. Methods and results Patients enrolled in the ESC-EHRA EURObservational Research Programme in AF General Long-Term Registry with baseline data to evaluate ABC criteria and available follow-up data were considered for this analysis. Among the original 11 096 AF patients enrolled, 6646 (59.9%) were included in this analysis, of which 1996 (30.0%) managed as ABC adherent. Patients adherent to ABC care had lower CHA2DS2-VASc and HAS-BLED scores (mean ± SD, 2.68 ± 1.57 vs. 3.07 ± 1.90 and 1.26 ± 0.93 vs. 1.58 ± 1.12, respectively; P Conclusion In a large contemporary cohort of European AF patients, a clinical management adherent to ABC pathway for integrated care is associated with a significant lower risk for cardiovascular events, CV death, and all-cause death.

Published
2021

27. Relationships between left ventricular mass and QRS duration in diverse types of left ventricular hypertrophy

Author

Domain, Guillaume, primary, Chouquet, Cecile, additional, Réant, Patricia, additional, Bongard, Vanina, additional, Vedis, Theo, additional, Rollin, Anne, additional, Mandel, Franck, additional, Delasnerie, Hubert, additional, Voglimacci-Stephanopoli, Quentin, additional, Mondoly, Pierre, additional, Beneyto, Maxime, additional, Cariou, Eve, additional, Fournier, Pauline, additional, Delmas, Clément, additional, Galinier, Michel, additional, Carrié, Didier, additional, Lafitte, Stéphane, additional, Lairez, Olivier, additional, Ferrières, Jean, additional, Cochet, Hubert, additional, and Maury, Philippe, additional

Published
2021
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28. Tout ce que vous avez toujours voulu savoir sur l'ECG : sans jamais oser le demander

Author

Mandel, Franck, Mandel, Franck, Mandel, Franck, and Mandel, Franck

Abstract

L’ECG…trois lettres qui ont déjà effrayé plus d’un externe ! Ce livre reprend les connaissances essentielles nécessaires à une meilleure appréhension de l’ECG pour les ECNi.Chaque chapitre est organisé en une partie "cours" suivie d’une partie "interprétation d’ECG" sous forme de QCM, afin de mieux assimiler les différentes notions présentées.Ainsi, vous ne raterez aucun des nombreux diagnostics qui vous seront demandés le jour J.Car aux ECNi comme dans la vraie vie vous serez forcément confrontés à différents tracés plus ou moins délicats… sauf que dans le premier cas vous n’aurez pas d’avis cardio à disposition !Alors approfondissez bien l’ECG, cela peut faire la différence.

Published
2018

29. Relationships between left ventricular mass and QRS duration in diverse types of left ventricular hypertrophy.

Author

Domain, Guillaume, Chouquet, Cecile, Réant, Patricia, Bongard, Vanina, Vedis, Theo, Rollin, Anne, Mandel, Franck, Delasnerie, Hubert, Voglimacci-Stephanopoli, Quentin, Mondoly, Pierre, Beneyto, Maxime, Cariou, Eve, Fournier, Pauline, Delmas, Clément, Galinier, Michel, Carrié, Didier, Lafitte, Stéphane, Lairez, Olivier, Ferrières, Jean, and Cochet, Hubert

Subjects
LEFT heart ventricle, STATISTICS, LEFT ventricular hypertrophy, MULTIVARIATE analysis, MAGNETIC resonance imaging, RETROSPECTIVE studies, ELECTROCARDIOGRAPHY
Abstract

Aims Hypertrophic cardiomyopathy (HCM) may be associated with very narrow QRS, while left ventricular hypertrophy (LVH) may increase QRS duration. We investigated the relationships between QRS duration and LV mass (LVM) in subtypes of abnormal LV wall thickness. Methods and results Automated measurement of LVM on MRI was correlated to automated measurement of QRS duration on ECG in HCM, left ventricular non compaction (LVNC), left ventricular hypertrophy (LVH), and controls with healthy hearts. Uni and multivariate analyses were performed between groups including explanatory variables expected to influence LVM and QRS duration. The relationships between QRS duration and LVM were further studied within each group. Two hundred and twenty-one HCM, 28 LVNC, 16 LVH, and 40 controls were retrospectively included. Mean QRS duration was 92 ms for HCM, 104 for LVNC, 110 for LVH, and 92 for controls (P  < 0.01). Mean LVM was 100, 90, 108, and 68 g/m2 (P  < 0.01). QRS duration, LVM, hypertension, maximal wall thickness, and late gadolinium enhancement were significantly linked to HCM in multivariate analysis (w/wo bundle branch block). An independent negative correlation was found between LVM and QRS duration in the HCM group, while the relationship was reverse in LVNC, LVH, and controls. Conclusion QRS duration increases with LVM in LVNC, LVH, or in healthy hearts, while reverse relationship is present in HCM. These relationships were independent from other parameters. These results warrant additional investigations for refining diagnosis criteria for HCM in the future. [ABSTRACT FROM AUTHOR]

Published
2022
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31. Long-Term Follow-Up of Patients With Tetralogy of Fallot and Implantable Cardioverter Defibrillator

Author

Waldmann, Victor, primary, Bouzeman, Abdeslam, additional, Duthoit, Guillaume, additional, Koutbi, Linda, additional, Bessiere, Francis, additional, Labombarda, Fabien, additional, Marquié, Christelle, additional, Gourraud, Jean Baptiste, additional, Mondoly, Pierre, additional, Sellal, Jean Marc, additional, Bordachar, Pierre, additional, Hermida, Alexis, additional, Anselme, Frédéric, additional, Asselin, Anouk, additional, Audinet, Caroline, additional, Bernard, Yvette, additional, Boveda, Serge, additional, Bru, Paul, additional, Bun, Sok Sithikun, additional, Clerici, Gael, additional, Da Costa, Antoine, additional, de Guillebon, Maxime, additional, Defaye, Pascal, additional, Elbaz, Nathalie, additional, Eschalier, Romain, additional, Garcia, Rodrigue, additional, Guenancia, Charles, additional, Guy-Moyat, Benoit, additional, Halimi, Franck, additional, Irles, Didier, additional, Iserin, Laurence, additional, Jourda, François, additional, Ladouceur, Magalie, additional, Lagrange, Philippe, additional, Laredo, Mikael, additional, Mansourati, Jacques, additional, Massoulié, Grégoire, additional, Mathiron, Amel, additional, Maury, Philippe, additional, Messali, Anne, additional, Narayanan, Kumar, additional, Nguyen, Cédric, additional, Ninni, Sandro, additional, Perier, Marie-Cécile, additional, Pierre, Bertrand, additional, Pujadas, Penelope, additional, Sacher, Frédéric, additional, Sagnol, Pascal, additional, Sharifzadehgan, Ardalan, additional, Walton, Camille, additional, Winum, Pierre, additional, Zakine, Cyril, additional, Fauchier, Laurent, additional, Martins, Raphael, additional, Pasquié, Jean Luc, additional, Thambo, Jean Benoit, additional, Jouven, Xavier, additional, Combes, Nicolas, additional, Marijon, Eloi, additional, Squara, Fabien, additional, Theodore, Guillaume, additional, Scarlatti, Didier, additional, Hourdain, Jérome, additional, Deharo, Jean-Claude, additional, Ollitrault, Pierre, additional, Milliez, Paul, additional, Champ-Rigot, Laure, additional, Bader, Hugues, additional, Duplantier, Cécile, additional, Milhem, Antoine, additional, Sagnard, Audrey, additional, Bertaux, Géraldine, additional, Laurent, Gabriel, additional, Badoz, Marc, additional, Bortone, Agustin, additional, Laborie, Guillaume, additional, Rollin, Anne, additional, Stephanopoli, Quentin Voglimacci, additional, Mandel, Franck, additional, Duparc, Alexandre, additional, Domain, Guillaume, additional, Albenque, Jean-Paul, additional, Cardin, Christèle, additional, Combes, Stéphane, additional, Tanese, Nikita, additional, Hasni, Karim, additional, Leclercq, Christophe, additional, Galand, Vincent, additional, Pavin, Dominique, additional, Mabo, Philippe, additional, Behar, Nathalie, additional, Clementy, Nicolas, additional, Loose, Christophe, additional, Otmani, Akli, additional, Venier, Sandrine, additional, Carabelli, Adrien, additional, Jacon, Peggy, additional, Kilani, Mouna Ben, additional, Guichard, Jean Bapstist, additional, Romeyer-Bouchard, Cécile, additional, Le Gloan, Laurianne, additional, Probst, Vincent, additional, Freysz, Luc, additional, Blangy, Hugues, additional, Chillou, Christian De, additional, Sadoul, Nicolas, additional, Khattar, Pierre, additional, Potelle, Charlotte, additional, Jean, Frederic, additional, Puie, Paul, additional, Khoueiry, Ziad, additional, Chevallier, Philippe, additional, Dulac, Arnaud, additional, Filippo, Sylvie Di, additional, Gardey, Kevin, additional, Frey, Pierre, additional, Akret, Chrystelle, additional, Dompnier, Antoine, additional, Maupain, Carole, additional, Waintraub, Xavier, additional, Hidden-Lucet, Françoise, additional, Chastre, Thomas, additional, Gandjbakhch, Estelle, additional, Badenco, Nicolas, additional, Extramiana, Fabrice, additional, Leenhardt, Antoine, additional, Zouaghi, Amir, additional, Algalarrondo, Vincent, additional, Amet, Denis, additional, Varlet, Emilie, additional, Chalbia, Tej, additional, Philibert, Séverine, additional, Ollitrault, Jacky, additional, Lavergne, Thomas, additional, Baudinaud, Pierre, additional, Mirolo, Adrian, additional, Savouré, Arnaud, additional, Godin, Bénédicte, additional, Bertrand, Cathy, additional, Fiorello, Pierre, additional, Johnson, Nicolas, additional, Lallemand, Pierre-Marc, additional, Herminda, Alexis, additional, Hermida, Jean-Sylvain, additional, Degand, Bruno, additional, Bouazzaou, Rim El, additional, Mourot, Stéphane, additional, Goussot, Samuel, additional, Jauvert, Gaël, additional, Lazarus, Arnaud, additional, Grimard, Caroline, additional, Alonso, Christine, additional, Zhao, Alexandre, additional, Thomas, Olivier, additional, Cauchemez, Bruno, additional, Moubarak, Ghassan, additional, Lellouche, Nicolas, additional, Hamon, David, additional, Enache, Bogdan, additional, Lactu, Gabriel, additional, Wiart, Françoise, additional, Geoffroy, Olivier, additional, Poindron, Damien, additional, Maltret, Alice, additional, Raimondo, Cristine, additional, Bonnet, Damien, additional, Hascoët, Sébastien, additional, Derval, Nicolas, additional, Haïssaguerre, Michel, additional, and Hocini, Mélèze, additional

Published
2020
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34. Creation of sinus rhythm and paced maps using a single acquisition step: the “one acquisition-two maps” technique—a feasibility study

Author

Voglimacci-Stephanopoli, Quentin, primary, Sacher, Frederic, additional, Martin, Claire, additional, Meyer, Christian, additional, Martin, Ruairidh, additional, Rollin, Anne, additional, Capellino, Stefano, additional, Mondoly, Pierre, additional, Mandel, Franck, additional, Jaïs, Pierre, additional, Tabuteau, Maud, additional, and Maury, Philippe, additional

Published
2020
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35. Coagulation and heparin requirements during ablation in patients under oral anticoagulant drugs

Author

Maury, Philippe, primary, Belaid, Slimane, additional, Ribes, Agnès, additional, Voglimacci‐Stephanopoli, Quentin, additional, Mondoly, Pierre, additional, Blaye, Marie, additional, Mandel, Franck, additional, Monteil, Benjamin, additional, Carrié, Didier, additional, Galinier, Michel, additional, Bongard, Vanina, additional, Rollin, Anne, additional, and Voisin, Sophie, additional

Published
2020
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36. Chest pain in Brugada syndrome: Prevalence, correlations, and prognosis role

Author

Sebai, Fatiha, primary, Rollin, Anne, additional, Mondoly, Pierre, additional, Voglimacci‐Stephanopoli, Quentin, additional, Dupin‐Deguine, Delphine, additional, Bieth, Eric, additional, Hocini, Meleze, additional, Monteil, Benjamin, additional, Mandel, Franck, additional, Galinier, Michel, additional, Carrié, Didier, additional, Haïssaguerre, Michel, additional, Sacher, Frederic, additional, and Maury, Philippe, additional

Published
2020
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38. Incidence, epidemiology, diagnosis and prognosis of atrio-oesophageal fistula following percutaneous catheter ablation: a French nationwide survey.

Author

Gandjbakhch, Estelle, Mandel, Franck, Dagher, Yann, Hidden-Lucet, Francoise, Rollin, Anne, and Maury, Philippe

Subjects
ATRIAL fibrillation diagnosis, ESOPHAGEAL fistula, ATRIAL fibrillation, CATHETER ablation, PROGNOSIS, DISEASE incidence, TREATMENT effectiveness
Abstract

Aims: Rate, incidence, risk factors, and optimal management of atrio-oesophageal fistula (AOF) after catheter ablation for atrial fibrillation (AF) remain obscure.Methods and Results: All French centres performing AF ablation were identified and surveys were sent concerning the number of procedures, eventual cases of AOF, and characteristics of such cases. Eighty-two of the 103 centres (80%) performing AF ablation in France were included, with a total of 129 286 AF ablations since 2006 (93% of the whole procedures in France). Thirty-three AOF were reported (reported rate 0.026% per procedure) with a stable reported annual incidence despite the increasing number of procedures. Sensitivity of computed tomography (CT) scan for AOF was 81%. Mortality was 60%, significantly lower in case of surgical corrective therapy (31 vs. 93%, P = 0.001).Conclusion: The reported rate of AOF after AF ablation in this nationwide survey was 0.026%, with a stable reported annual incidence over time. A normal CT scan does not rule out the diagnosis and should be repeated in case of suspicion. Prognosis remains poor with a mortality of 60% and crucially dependant of immediate surgical correction. No clear protective strategy has been proven effective. [ABSTRACT FROM AUTHOR]

Published
2021
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39. Structural evidence for a new elaborate 3D-organization of the cardiomyocyte lateral membrane in adult mammalian cardiac tissues

Author

Guilbeau-Frugier, Céline, primary, Cauquil, Marie, additional, Karsenty, Clément, additional, Lairez, Olivier, additional, Dambrin, Camille, additional, Payré, Bruno, additional, Cassard, Hervé, additional, Josse, Claudie, additional, Seguelas, Marie-Hélène, additional, Allart, Sophie, additional, Branchereau, Maxime, additional, Heymes, Christophe, additional, Mandel, Franck, additional, Delisle, Marie-Bernadette, additional, Pathak, Atul, additional, Dague, Etienne, additional, Sénard, Jean-Michel, additional, and Galés, Céline, additional

Published
2018
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40. Structural evidence for a new elaborate 3D-organization of the cardiomyocyte lateral membrane in adult mammalian cardiac tissues.

Author

Guilbeau-Frugier, Céline, Cauquil, Marie, Karsenty, Clément, Lairez, Olivier, Dambrin, Camille, Payré, Bruno, Cassard, Hervé, Josse, Claudie, Seguelas, Marie-Hélène, Allart, Sophie, Branchereau, Maxime, Heymes, Christophe, Mandel, Franck, Delisle, Marie-Bernadette, Pathak, Atul, Dague, Etienne, Sénard, Jean-Michel, and Galés, Céline

Subjects
HEART cells, ATOMIC force microscopy, BASAL lamina, TISSUES
Abstract

Aims This study explored the lateral crest structures of adult cardiomyocytes (CMs) within healthy and diseased cardiac tissue. Methods and results Using high-resolution electron and atomic force microscopy, we performed an exhaustive quantitative analysis of the three-dimensional (3D) structure of the CM lateral surface in different cardiac compartments from various mammalian species (mouse, rat, cow, and human) and determined the technical pitfalls that limit its observation. Although crests were observed in nearly all CMs from all heart compartments in all species, we showed that their heights, dictated by the subsarcolemmal mitochondria number, substantially differ between compartments from one species to another and tightly correlate with the sarcomere length. Differences in crest heights also exist between species; for example, the similar cardiac compartments in cows and humans exhibit higher crests than rodents. Unexpectedly, we found that lateral surface crests establish tight junctional contacts with crests from neighbouring CMs. Consistently, super-resolution SIM or STED-based immunofluorescence imaging of the cardiac tissue revealed intermittent claudin-5-claudin-5 interactions in trans via their extracellular part and crossing the basement membrane. Finally, we found a loss of crest structures and crest–crest contacts in diseased human CMs and in an experimental mouse model of left ventricle barometric overload. Conclusion Overall, these results provide the first evidence for the existence of differential CM surface crests in the cardiac tissue as well as the existence of CM–CM direct physical contacts at their lateral face through crest–crest interactions. We propose a model in which this specific 3D organization of the CM lateral membrane ensures the myofibril/myofiber alignment and the overall cardiac tissue cohesion. A potential role in the control of sarcomere relaxation and of diastolic ventricular dysfunction is also discussed. Whether the loss of CM surface crests constitutes an initial and common event leading to the CM degeneration and the setting of heart failure will need further investigation. [ABSTRACT FROM AUTHOR]

Published
2019
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41. Premature Ventricular Contractions and Ultra-High-Definition Mapping. Contribution and Limits.

Author

Maury, Philippe, Voglimacci-Stephanopoli, Quentin, Monteil, Benjamin, Beneyto, Maxime, Mondoly, Pierre, Mandel, Franck, and Rollin, Anne

Subjects
*ARRHYTHMIA, *FLUOROSCOPY
Abstract

Background: The utility of ultra-high definition mapping (UHDM) for ablation of premature ventricular contractions (PVC) remains undetermined. The aim of this study was to investigate UHDM for PVC ablation, and additionally to compare to conventional technique. Methods: Twenty patients investigated using UHDM were prospectively included and analyzed. Electrophysiological caracteristics and results were compared to 40 patients ablated using fluoroscopy only. Results: 2541±2033 EGMs and 331±240 PVC beats were recorded for each patient. Surfaces of isochronal activations were 2.3±1.7 and 6.9±6.1 cm2 (first 10 and 20 ms). Local scar was present in 40% and local block in 65%. Areas of pace-mapping > 95, 90 and 85% concordance were 1.5±3.4, 2.1±3.9 and 3.3±5 cm2. Mean distance between the ablation site and the site of best pace-mapping or of earliest activation was 8±8 mm and 5±7 mm. Pre-potential was noted in 17% vs 26% controls (ns). QS pattern was present in 83% vs 83% controls (ns), and earliest activation was - 31±50 vs - 25±14 ms in controls (ns). Procedure (100±36 vs 190±51 min, p< 0.0001) and fluoroscopy duration (15±9 vs 24±9 min, p=0.005) were shorter in controls. Acute success was achieved in 65% patients with UHDM and in 72% controls (p=ns) with lower residual PVC burden in the control group. Over a follow-up of 19±12 months, long-term success was similar between groups (65 vs 68%). Conclusion: UHDM may reveal poorly recognized activation features and PVC mechanism. In this series, conventional mapping was quicker and did clinically as well as UHDM. [ABSTRACT FROM AUTHOR]

Published
2021

45. Relationships between left ventricular mass and QRS duration in diverse types of left ventricular hypertrophy.

Author

Domain G, Chouquet C, Réant P, Bongard V, Vedis T, Rollin A, Mandel F, Delasnerie H, Voglimacci-Stephanopoli Q, Mondoly P, Beneyto M, Cariou E, Fournier P, Delmas C, Galinier M, Carrié D, Lafitte S, Lairez O, Ferrières J, Cochet H, and Maury P

Subjects
Contrast Media, Electrocardiography methods, Gadolinium, Humans, Hypertrophy, Left Ventricular complications, Hypertrophy, Left Ventricular diagnostic imaging, Retrospective Studies, Cardiomyopathy, Hypertrophic complications, Cardiomyopathy, Hypertrophic diagnostic imaging, Hypertension diagnosis
Abstract

Aims: Hypertrophic cardiomyopathy (HCM) may be associated with very narrow QRS, while left ventricular hypertrophy (LVH) may increase QRS duration. We investigated the relationships between QRS duration and LV mass (LVM) in subtypes of abnormal LV wall thickness., Methods and Results: Automated measurement of LVM on MRI was correlated to automated measurement of QRS duration on ECG in HCM, left ventricular non compaction (LVNC), left ventricular hypertrophy (LVH), and controls with healthy hearts. Uni and multivariate analyses were performed between groups including explanatory variables expected to influence LVM and QRS duration. The relationships between QRS duration and LVM were further studied within each group. Two hundred and twenty-one HCM, 28 LVNC, 16 LVH, and 40 controls were retrospectively included. Mean QRS duration was 92 ms for HCM, 104 for LVNC, 110 for LVH, and 92 for controls (P < 0.01). Mean LVM was 100, 90, 108, and 68 g/m2 (P < 0.01). QRS duration, LVM, hypertension, maximal wall thickness, and late gadolinium enhancement were significantly linked to HCM in multivariate analysis (w/wo bundle branch block). An independent negative correlation was found between LVM and QRS duration in the HCM group, while the relationship was reverse in LVNC, LVH, and controls., Conclusion: QRS duration increases with LVM in LVNC, LVH, or in healthy hearts, while reverse relationship is present in HCM. These relationships were independent from other parameters. These results warrant additional investigations for refining diagnosis criteria for HCM in the future., (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2021. For permissions, please email: journals.permissions@oup.com.)

Published
2022
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47. Premature Ventricular Contractions and Ultra-High-Definition Mapping. Contribution and Limits.

Author

Maury P, Voglimacci-Stephanopoli Q, Monteil B, Beneyto M, Mondoly P, Mandel F, and Rollin A

Abstract

Background: The utility of ultra-high definition mapping (UHDM) for ablation of premature ventricular contractions (PVC) remains undetermined. The aim of this study was to investigate UHDM for PVC ablation, and additionally to compare to conventional technique., Methods: Twenty patients investigated using UHDM were prospectively included and analyzed. Electrophysiological caracteristics and results were compared to 40 patients ablated using fluoroscopy only., Results: 2541±2033 EGMs and 331±240 PVC beats were recorded for each patient. Surfaces of isochronal activations were 2.3±1.7 and 6.9±6.1 cm 2 (first 10 and 20 ms). Local scar was present in 40% and local block in 65%. Areas of pace-mapping > 95, 90 and 85% concordance were 1.5±3.4, 2.1±3.9 and 3.3±5 cm 2 . Mean distance between the ablation site and the site of best pace-mapping or of earliest activation was 8±8 mm and 5±7 mm. Pre-potential was noted in 17% vs 26% controls (ns). QS pattern was present in 83% vs 83% controls (ns), and earliest activation was - 31±50 vs - 25±14 ms in controls (ns). Procedure (100±36 vs 190±51 min, p< 0.0001) and fluoroscopy duration (15±9 vs 24±9 min, p=0.005) were shorter in controls. Acute success was achieved in 65% patients with UHDM and in 72% controls (p=ns) with lower residual PVC burden in the control group. Over a follow-up of 19±12 months, long-term success was similar between groups (65 vs 68%)., Conclusions: UHDM may reveal poorly recognized activation features and PVC mechanism. In this series, conventional mapping was quicker and did clinically as well as UHDM.

Published
2021
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48. Incidence, epidemiology, diagnosis and prognosis of atrio-oesophageal fistula following percutaneous catheter ablation: a French nationwide survey.

Author

Gandjbakhch E, Mandel F, Dagher Y, Hidden-Lucet F, Rollin A, and Maury P

Subjects
Humans, Incidence, Prognosis, Treatment Outcome, Atrial Fibrillation diagnosis, Atrial Fibrillation epidemiology, Atrial Fibrillation surgery, Catheter Ablation adverse effects, Esophageal Fistula diagnostic imaging, Esophageal Fistula epidemiology
Abstract

Aims: Rate, incidence, risk factors, and optimal management of atrio-oesophageal fistula (AOF) after catheter ablation for atrial fibrillation (AF) remain obscure., Methods and Results: All French centres performing AF ablation were identified and surveys were sent concerning the number of procedures, eventual cases of AOF, and characteristics of such cases. Eighty-two of the 103 centres (80%) performing AF ablation in France were included, with a total of 129 286 AF ablations since 2006 (93% of the whole procedures in France). Thirty-three AOF were reported (reported rate 0.026% per procedure) with a stable reported annual incidence despite the increasing number of procedures. Sensitivity of computed tomography (CT) scan for AOF was 81%. Mortality was 60%, significantly lower in case of surgical corrective therapy (31 vs. 93%, P = 0.001)., Conclusion: The reported rate of AOF after AF ablation in this nationwide survey was 0.026%, with a stable reported annual incidence over time. A normal CT scan does not rule out the diagnosis and should be repeated in case of suspicion. Prognosis remains poor with a mortality of 60% and crucially dependant of immediate surgical correction. No clear protective strategy has been proven effective., (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2020. For permissions, please email: journals.permissions@oup.com.)

Published
2021
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