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The design of graded and multifunctional lattice cores is driven by the increasing demand for high-performance components in lightweight engineering. This trend benefits from significant achievements in additive manufacturing, where the lattice core and the face sheets are fabricated simultaneously in a single print job. This work systematically compares the mechanical performance of sandwich panels comprising various graded lattice cores subjected to concentrated loads. In addition to graded lattice cores, uniform lattices and conventional honeycomb cores are analyzed. To obtain an optimized graded lattice core, a fully stressed design method is applied. Stresses and displacements are determined using a linear elastic analytical model that allows grading the core properties in a layerwise manner through the core thickness. The analysis indicates the superior performance of graded lattice cores compared to homogeneous lattice cores. However, conventional honeycombs outperform graded lattice cores in terms of load-to-weight ratio and stiffness-to-weight ratio. This study provides valuable insights for the design of lattice core sandwich panels and the advantages of several design approaches.