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1. Human Campylobacter spp. infections in Italy

Author

Zerbato, Verena, Di Bella, Stefano, Pol, Riccardo, Luzzati, Roberto, Sanson, Gianfranco, Ambretti, Simone, Andreoni, Stefano, Aschbacher, Richard, Bernardo, Mariano, Bielli, Alessandra, Brigante, Gioconda, Busetti, Marina, Camarlinghi, Giulio, Carcione, Davide, Carducci, Antonella, Clementi, Nicola, Carretto, Edoardo, Chilleri, Chiara, Codda, Giulia, Consonni, Alessandra, Costantino, Venera, Cortazzo, Venere, Di Santolo, Manuela, Dodaro, Saveria, Fiori, Barbara, García-Fernández, Aurora, Foschi, Claudio, Gobbato, Elisa, Greco, Francesca, La Ragione, Roberto Marcello, Mancini, Nicasio, Maraolo, Alberto Enrico, Marchese, Anna, Marcuccio, Daniela, Marrollo, Roberta, Mauri, Carola, Mazzariol, Annarita, Morroni, Gianluca, Mosca, Adriana, Nigrisoli, Giacomo, Pagani, Elisabetta, Parisio, Eva Maria, Pollini, Simona, Sarti, Mario, Sorrentino, Annarita, Trotta, Domenico, Villa, Laura, Vismara, Chiara, and Principe, Luigi

Published
2024
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2. Epidemiological impact of human adenovirus as causative agent of respiratory infections: An Italian multicentre retrospective study, 2022–2023

Author

Giardina, Federica A.M., Pellegrinelli, Laura, Novazzi, Federica, Vian, Elisa, Biscaro, Valeria, Russo, Cristina, Ranno, Stefania, Pagani, Elisabetta, Masi, Elisa, Tiberio, Claudia, Esposito, Martina, Uceda Renteria, Sara, Callegaro, Annapaola, Piccirilli, Giulia, Lazzarotto, Tiziana, Rovida, Francesca, Galli, Cristina, Lalle, Eleonora, Maggi, Fabrizio, Mancini, Nicasio, Acciarri, Carla, Menzo, Stefano, Colacicco, Anna Maria, Scarasciulli, Maria, Piralla, Antonio, Baldanti, Fausto, and Pariani, Elena

Published
2024
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3. ACOD1 deficiency offers protection in a mouse model of diet-induced obesity by maintaining a healthy gut microbiota

Author

Eberhart, Tanja, Stanley, Federico Uchenna, Ricci, Luisa, Chirico, Tiziana, Ferrarese, Roberto, Sisti, Sofia, Scagliola, Alessandra, Baj, Andreina, Badurek, Sylvia, Sommer, Andreas, Culp-Hill, Rachel, Dzieciatkowska, Monika, Shokry, Engy, Sumpton, David, D’Alessandro, Angelo, Clementi, Nicola, Mancini, Nicasio, and Cardaci, Simone

Published
2024
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5. Levofloxacin prophylaxis vs no prophylaxis in patients with neutropenia within an endemic country for carbapenem-resistant GNB

Author

Clerici, Daniela, Galli, Laura, Greco, Raffaella, Lugli, Anna P., Erbella, Federico, Ripa, Marco, Tassan Din, Chiara, Nitti, Rosamaria, Giglio, Fabio, Mastaglio, Sara, Lorentino, Francesca, Xue, Elisabetta, Farina, Francesca, Liberatore, Carmine, Poli, Andrea, Carletti, Silvia, Lupo Stanghellini, Maria T., Carrabba, Matteo G., Assanelli, Andrea A., Ruggeri, Annalisa, Bernardi, Massimo, Corti, Consuelo, Peccatori, Jacopo, Mancini, Nicasio, Scarpellini, Paolo, Ciceri, Fabio, Castagna, Antonella, and Oltolini, Chiara

Published
2023
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6. Alterations of the intestinal mucus layer correlate with dysbiosis and immune dysregulation in human Type 1 Diabetes

Author

Lo Conte, Marta, Cosorich, Ilaria, Ferrarese, Roberto, Antonini Cencicchio, Martina, Nobili, Angelica, Palmieri, Vittoria, Massimino, Luca, Lamparelli, Luigi Antonio, Liang, Wenjie, Riba, Michela, Devecchi, Elisabetta, Bolla, Andrea Mario, Pedone, Erika, Scavini, Marina, Bosi, Emanuele, Fasano, Alessio, Ungaro, Federica, Diana, Julien, Mancini, Nicasio, and Falcone, Marika

Published
2023
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7. Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

Author

Patsopoulos, Nikolaos A, Baranzini, Sergio E, Santaniello, Adam, Shoostari, Parisa, Cotsapas, Chris, Wong, Garrett, Beecham, Ashley H, James, Tojo, Replogle, Joseph, Vlachos, Ioannis S, McCabe, Cristin, Pers, Tune H, Brandes, Aaron, White, Charles, Keenan, Brendan, Cimpean, Maria, Winn, Phoebe, Panteliadis, Ioannis-Pavlos, Robbins, Allison, Andlauer, Till FM, Zarzycki, Onigiusz, Dubois, Bénédicte, Goris, An, Søndergaard, Helle Bach, Sellebjerg, Finn, Sorensen, Per Soelberg, Ullum, Henrik, Thørner, Lise Wegner, Saarela, Janna, Cournu-Rebeix, Isabelle, Damotte, Vincent, Fontaine, Bertrand, Guillot-Noel, Lena, Lathrop, Mark, Vukusic, Sandra, Berthele, Achim, Pongratz, Viola, Buck, Dorothea, Gasperi, Christiane, Graetz, Christiane, Grummel, Verena, Hemmer, Bernhard, Hoshi, Muni, Knier, Benjamin, Korn, Thomas, Lill, Christina M, Luessi, Felix, Mühlau, Mark, Zipp, Frauke, Dardiotis, Efthimios, Agliardi, Cristina, Amoroso, Antonio, Barizzone, Nadia, Benedetti, Maria D, Bernardinelli, Luisa, Cavalla, Paola, Clarelli, Ferdinando, Comi, Giancarlo, Cusi, Daniele, Esposito, Federica, Ferrè, Laura, Galimberti, Daniela, Guaschino, Clara, Leone, Maurizio A, Martinelli, Vittorio, Moiola, Lucia, Salvetti, Marco, Sorosina, Melissa, Vecchio, Domizia, Zauli, Andrea, Santoro, Silvia, Mancini, Nicasio, Zuccalà, Miriam, Mescheriakova, Julia, van Duijn, Cornelia, Bos, Steffan D, Celius, Elisabeth G, Spurkland, Anne, Comabella, Manuel, Montalban, Xavier, Alfredsson, Lars, Bomfim, Izaura L, Gomez-Cabrero, David, Hillert, Jan, Jagodic, Maja, Lindén, Magdalena, Piehl, Fredrik, Jelčić, Ilijas, Martin, Roland, Sospedra, Mirela, Baker, Amie, Ban, Maria, Hawkins, Clive, Hysi, Pirro, Kalra, Seema, Karpe, Fredrik, Khadake, Jyoti, Lachance, Genevieve, Molyneux, Paul, and Neville, Matthew

Subjects
Neurosciences, Brain Disorders, Multiple Sclerosis, Human Genome, Autoimmune Disease, Clinical Research, Genetics, Neurodegenerative, Aetiology, 2.1 Biological and endogenous factors, Inflammatory and immune system, Neurological, Case-Control Studies, Cell Cycle Proteins, Chromosome Mapping, Chromosomes, Human, X, GTPase-Activating Proteins, Gene Frequency, Genetic Loci, Genome-Wide Association Study, Genomics, Humans, Inheritance Patterns, Major Histocompatibility Complex, Microglia, Polymorphism, Single Nucleotide, Quantitative Trait Loci, RNA-Seq, Transcriptome, International Multiple Sclerosis Genetics Consortium, General Science & Technology
Abstract

We analyzed genetic data of 47,429 multiple sclerosis (MS) and 68,374 control subjects and established a reference map of the genetic architecture of MS that includes 200 autosomal susceptibility variants outside the major histocompatibility complex (MHC), one chromosome X variant, and 32 variants within the extended MHC. We used an ensemble of methods to prioritize 551 putative susceptibility genes that implicate multiple innate and adaptive pathways distributed across the cellular components of the immune system. Using expression profiles from purified human microglia, we observed enrichment for MS genes in these brain-resident immune cells, suggesting that these may have a role in targeting an autoimmune process to the central nervous system, although MS is most likely initially triggered by perturbation of peripheral immune responses.

Published
2019

8. Reply to: Hultström et al., Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19. Mannose-binding lectin genetics in COVID-19

Author

Asselta, Rosanna, Paraboschi, Elvezia Maria, Stravalaci, Matteo, Invernizzi, Pietro, Bonfanti, Paolo, Biondi, Andrea, Pagani, Isabel, Pedotti, Mattia, Doni, Andrea, Scavello, Francesco, Mapelli, Sarah N., Sironi, Marina, Perucchini, Chiara, Varani, Luca, Matkovic, Milos, Cavalli, Andrea, Cesana, Daniela, Gallina, Pierangela, Pedemonte, Nicoletta, Capurro, Valeria, Clementi, Nicola, Mancini, Nicasio, Bayarri-Olmos, Rafael, Garred, Peter, Rappuoli, Rino, Duga, Stefano, Bottazzi, Barbara, Uguccioni, Mariagrazia, Vicenzi, Elisa, Mantovani, Alberto, and Garlanda, Cecilia

Published
2022
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10. Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules

Author

Stravalaci, Matteo, Pagani, Isabel, Paraboschi, Elvezia Maria, Pedotti, Mattia, Doni, Andrea, Scavello, Francesco, Mapelli, Sarah N., Sironi, Marina, Perucchini, Chiara, Varani, Luca, Matkovic, Milos, Cavalli, Andrea, Cesana, Daniela, Gallina, Pierangela, Pedemonte, Nicoletta, Capurro, Valeria, Clementi, Nicola, Mancini, Nicasio, Invernizzi, Pietro, Bayarri-Olmos, Rafael, Garred, Peter, Rappuoli, Rino, Duga, Stefano, Bottazzi, Barbara, Uguccioni, Mariagrazia, Asselta, Rosanna, Vicenzi, Elisa, Mantovani, Alberto, and Garlanda, Cecilia

Published
2022
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11. Molecular characterization of emerging Echovirus 11 (E11) shed light on the recombinant origin of a variant associated with severe hepatitis in neonates

Author

Piralla, Antonio, primary, Giardina, Federica, additional, Ferrari, Guglielmo, additional, Gaiarsa, Stefano, additional, Romano, Greta, additional, Pellegrinelli, Laura, additional, Galli, Cristina, additional, Seiti, Arlinda, additional, Binda, Sandro, additional, Pitrolo, Antonino Maria Guglielmo, additional, Genoni, Angelo, additional, Ferrante, Francesca Drago, additional, Novazzi, Federica, additional, Mancini, Nicasio, additional, Rovida, Francesca, additional, Pariani, Elena, additional, and Baldanti, Fausto, additional

Published
2024
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13. A spatial multi-scale fluorescence microscopy toolbox discloses entry checkpoints of SARS-CoV-2 variants in Vero E6 cells

Author

Storti, Barbara, Quaranta, Paola, Di Primio, Cristina, Clementi, Nicola, Mancini, Nicasio, Criscuolo, Elena, Spezia, Pietro Giorgio, Carnicelli, Vittoria, Lottini, Giulia, Paolini, Emanuele, Freer, Giulia, Lai, Michele, Costa, Mario, Beltram, Fabio, Diaspro, Alberto, Pistello, Mauro, Zucchi, Riccardo, Bianchini, Paolo, Signore, Giovanni, and Bizzarri, Ranieri

Published
2021
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14. COVID-eVax, a vaccine candidate encoding the SARS-CoV-2 receptor binding domain, elicits immune responses in animal models of COVID-19

Author

Conforti, Antonella, Marra, Emanuele, Palombo, Fabio, Roscilli, Giuseppe, Ravà, Micol, Fumagalli, Valeria, Muzi, Alessia, Maffei, Mariano, Luberto, Laura, Lione, Lucia, Salvatori, Erika, Compagnone, Mirco, Pinto, Eleonora, Pavoni, Emiliano, Bucci, Federica, Vitagliano, Grazia, Stoppoloni, Daniela, Pacello, Maria Lucrezia, Cappelletti, Manuela, Ferrara, Fabiana Fosca, D’Acunto, Emanuela, Chiarini, Valerio, Arriga, Roberto, Nyska, Abraham, Di Lucia, Pietro, Marotta, Davide, Bono, Elisa, Giustini, Leonardo, Sala, Eleonora, Perucchini, Chiara, Paterson, Jemma, Ryan, Kathryn Ann, Challis, Amy-Rose, Matusali, Giulia, Colavita, Francesca, Caselli, Gianfranco, Criscuolo, Elena, Clementi, Nicola, Mancini, Nicasio, Groß, Rüdiger, Seidel, Alina, Wettstein, Lukas, Münch, Jan, Donnici, Lorena, Conti, Matteo, De Francesco, Raffaele, Kuka, Mirela, Ciliberto, Gennaro, Castilletti, Concetta, Capobianchi, Maria Rosaria, Ippolito, Giuseppe, Guidotti, Luca G., Rovati, Lucio, Iannacone, Matteo, and Aurisicchio, Luigi

Published
2021
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15. Combined Use of Phenotypic Screening and of a Novel Commercial Assay (REALQUALITY Carba-Screen) for the Rapid Molecular Detection of Carbapenemases: A Single-Center Experience.

Author

Novazzi, Federica, Arcari, Gabriele, Drago Ferrante, Francesca, Boutahar, Sara, Genoni, Angelo Paolo, Carcione, Davide, Cassani, Gianluca, Gigante, Paolo, Carbotti, Mattia, Capuano, Riccardo, Pasciuta, Renée, and Mancini, Nicasio

Subjects
MEDICAL screening, DRUG resistance in microorganisms, PHENOTYPES, PUBLIC health
Abstract

Carbapenem resistance is a serious public health threat, causing numerous deaths annually primarily due to healthcare-associated infections. To face this menace, surveillance programs in high-risk patients are becoming a widespread practice. Here we report the performance of the combined use of a recently approved commercial multiplex real-time PCR assay (REALQUALITY Carba-Screen kit) with conventional phenotypic screening. In this three-month study, 479 rectal swabs from 309 patients across high-risk units were evaluated by combining the two approaches. Although the molecular assay showed a higher positivity rate than phenotypic screening (7.1% vs. 5%), it should be noted that the molecular method alone would have missed eight carbapenem-resistant isolates, while using only phenotypic screening would not have detected sixteen isolates. This demonstrates the complementary strengths of each method. Our study confirms the need for a combined approach to maximize the possible clinical impact of this kind of screening, ensuring a more comprehensive detection of resistant strains. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Torquetenovirus Viremia Quantification Using Real-Time PCR Developed on a Fully Automated, Random-Access Platform.

Author

Spezia, Pietro Giorgio, Carletti, Fabrizio, Novazzi, Federica, Specchiarello, Eliana, Genoni, Angelo, Drago Ferrante, Francesca, Minosse, Claudia, Matusali, Giulia, Mancini, Nicasio, Focosi, Daniele, Antonelli, Guido, Girardi, Enrico, and Maggi, Fabrizio

Subjects
VIREMIA, TURNAROUND time, CLINICAL pathology, TRANSPLANTATION of organs, tissues, etc., IMMUNITY, TACROLIMUS
Abstract

Quantification of Torquetenovirus (TTV) viremia is becoming important for evaluating the status of the immune system in solid organ transplant recipients, monitoring the appearance of post-transplant complications, and controlling the efficacy of maintenance immunosuppressive therapy. Thus, diagnostic approaches able to scale up TTV quantification are needed. Here, we report on the development and validation of a real-time PCR assay for TTV quantification on the Hologic Panther Fusion® System by utilizing its open-access channel. The manual real-time PCR previously developed in our laboratories was optimized to detect TTV DNA on the Hologic Panther Fusion® System. The assay was validated using clinical samples. The automated TTV assay has a limit of detection of 1.6 log copies per ml of serum. Using 112 samples previously tested via manual real-time PCR, the concordance in TTV detection was 93% between the assays. When the TTV levels were compared, the overall agreement between the methods, as assessed using Passing–Bablok linear regression and Bland–Altman analyses, was excellent. In summary, we validated a highly sensitive and accurate method for the diagnostic use of TTV quantification on a fully automated Hologic Panther Fusion® System. This will greatly improve the turnaround time for TTV testing and better support the laboratory diagnosis of this new viral biomarker. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Beauveria bassiana Keratitis: A Case Series and Review of Literature

Author

Knutsson, Karl Anders, primary, Rama, Paolo, additional, Tombolini, Beatrice, additional, Di Biase, Carlo, additional, Senni, Carlotta, additional, Buffoli, Fabio, additional, Clementi, Nicola, additional, Tonelli, Marco, additional, Carletti, Silvia, additional, Mancini, Nicasio, additional, Ferrari, Giulio, additional, Paganoni, Giorgio, additional, and Bandello, Francesco, additional

Published
2023
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19. Genetic characterization of Klebsiella pneumoniae carbapenemase -producing Klebsiella pneumoniae isolates with different susceptibility to ceftazidime/avibactam in patients with blood-stream infections

Author

Badalucco Ciotta, Flavia, primary, Saluzzo, Francesca, additional, Pescò, Alessandra, additional, Di Marco, Federico, additional, Carletti, Silvia, additional, Ripa, Marco, additional, Mancini, Nicasio, additional, Cirillo, Daniela M., additional, Castagna, Antonella, additional, and Oltolini, Chiara, additional

Published
2023
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20. New Antimicrobials for Gram-Positive Sustained Infections: A Comprehensive Guide for Clinicians

Author

Carcione, Davide, primary, Intra, Jari, additional, Andriani, Lilia, additional, Campanile, Floriana, additional, Gona, Floriana, additional, Carletti, Silvia, additional, Mancini, Nicasio, additional, Brigante, Gioconda, additional, Cattaneo, Dario, additional, Baldelli, Sara, additional, Chisari, Mattia, additional, Piccirilli, Alessandra, additional, Di Bella, Stefano, additional, and Principe, Luigi, additional

Published
2023
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21. OA-01 Exploiting microbiota commensals to potentiate immunotherapy and delay multiple myeloma evolution

Author

Cogrossi, Laura Lucia, primary, Ferrarese, Roberto, additional, Grioni, Matteo, additional, Zordan, Paola, additional, Mattorre, Benedetta, additional, Lorenzoni, Marco, additional, Meregalli, Greta, additional, Policastro, Anna, additional, Sisti, Sofia, additional, Brevi, Arianna, additional, Chesi, Marta, additional, Bergsagel, Leif, additional, Clementi, Nicola, additional, Mancini, Nicasio, additional, and Matteo, Bellone, additional

Published
2023
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23. Nanosphere’s Verigene® Blood Culture Assay to Detect Multidrug-Resistant Gram-Negative Bacterial Outbreak: A Prospective Study on 79 Hematological Patients in a Country with High Prevalence of Antimicrobial Resistance

Author

Greco, Raffaella, Barbanti, Maria Chiara, Mancini, Nicasio, Infurnari, Laura, Pasciuta, Renée, Forcina, Alessandra, Oltolini, Chiara, Casirati, Gabriele, Mannina, Daniele, Giglio, Fabio, Messina, Carlo, Morelli, Mara, Lorentino, Francesca, Mastaglio, Sara, Perini, Tommaso, Vago, Luca, Scarpellini, Paolo, Carrabba, Matteo Giovanni, Stanghellini, Maria Teresa Lupo, Marktel, Sarah, Assanelli, Andrea, Bernardi, Massimo, Corti, Consuelo, Peccatori, Jacopo, Clementi, Massimo, and Ciceri, Fabio

Published
2019
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26. Adjuvant role of SeptiFast to improve the diagnosis of sepsis in a large cohort of hematological patients

Author

Greco, Raffaella, Barbanti, Maria Chiara, Mancini, Nicasio, Crucitti, Lara, Oltolini, Chiara, Forcina, Alessandra, Lorentino, Francesca, Vago, Luca, Messina, Carlo, Clerici, Daniela, Morelli, Mara, Giglio, Fabio, Lupo Stanghellini, Maria Teresa, Infurnari, Laura, Carrabba, Matteo G., Marktel, Sarah, Assanelli, Andrea, Scarpellini, Paolo, Bernardi, Massimo, Peccatori, Jacopo, Corti, Consuelo, Clementi, Massimo, and Ciceri, Fabio

Published
2018
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30. High Risk of Secondary Infections Following Thrombotic Complications in Patients With COVID-19

Author

Ripa, Marco, Galli, Laura, D’Angelo, Armando, Apruzzi, Luca, Palumbo, Diego, Campochiaro, Corrado, Tassan Din, Chiara, Danise, Anna, Da Prat, Valentina, Vitali, Giordano, Brugliera, Luigia, Poli, Andrea, Monardo, Roberta, Monti, Giacomo, Baccellieri, Domenico, De Cobelli, Francesco, Clementi, Massimo, Iannaccone, Sandro, Dagna, Lorenzo, Rovere-Querini, Patrizia, Ciceri, Fabio, Tresoldi, Moreno, Zangrillo, Alberto, Scarpellini, Paolo, Castagna, Antonella, Andolina, Andrea, Bigoloni, Alba, Bossolasco, Simona, Bruzzesi, Elena, Canetti, Diana, Castiglioni, Barbara, Cernuschi, Massimo, Chiurlo, Matteo, Cinque, Paola, Dell’Acqua, Raffaele, Della Torre, Liviana, Gianotti, Nicola, Guffanti, Monica, Hasson, Hamid, Messina, Emanuela, Morsica, Giulia, Nozza, Silvia, Ranzenigo, Martina, Uberti-Foppa, Caterina, Vinci, Concetta, Badalucco Ciotta, Flavia, Bottanelli, Martina, Clemente, Tommaso, Mainardi, Ilaria, Mori, Giovanni, Papaioannu Borjesson, Rebecka, Ponta, Giacomo, Muccini, Camilla, Mastrangelo, Andrea, Oltolini, Chiara, Spagnuolo, Vincenzo, Benassi, Luca, Bigai, Giorgia, Bozzolo, Enrica, Borio, Giorgia, Bussolari, Cecilia, Calvisi, Stefania, Canti, Valentina, Castellani, Jacopo, Cavallo, Ludovica, Cilla, Marta, Cinel, Elena, Compagnone, Nicola, D’Aliberti, Teresa, Damanti, Sarah, De Lorenzo, Rebecca, Di Lucca, Giuseppe, Di Terlizzi, Gaetano, Dumea, Iulia, Farolfi, Federica, Ferrante, Marica, Frangi, Claudia, Gallina, Gabriele, Germinario Bruno, Nicolò, Lanzillotta, Marco, Li Voti, Raffaele, Marinosci, Alessandro, Martinenghi, Sabina, Memoli, Massimo, Montagna, Marco, Pascali, Maria, Patrizi, Alessandro, Pomaranzi, Chiara, Scotti, Raffaella, Strada, Silvia, Boffini, Nicola, Cavalli, Giulio, Della Torre, Emanuel, De Luca, Giacomo, Farina, Nicola, Moroni, Luca, Ramirez Giuseppe, Alvise, Tomelleri, Alessandro, Azzolini Maria, Luisa, Baiardo Redaelli, Martina, Calabrò Maria, Grazia, Casiraghi Giuseppina, Maria, Dell’Acqua, Antonio, Fresilli, Stefano, Guzzo, Francesca, Landoni, Giovanni, Lombardi, Gaetano, Maimeri, Nicolò, Moizo, Elena, Nisi Francesco, Giuseppe, Oriani, Alessandro, Ortalda, Alessandro, Pasculli, Nicola, Pieri, Marina, Turi, Stefano, Bertoglio, Luca, Bilman, Victor, Carletti, Silvia, Gona, Floriana, Mancini, Nicasio, Della Valle, Patrizia, Molinari, Chiara, Poloniato, Antonella, Lalla, Francesca, Prestifilippo, Dario, Sapienza, Jacopo, Seghi, Federico, Ripa, Marco, Galli, Laura, D’Angelo, Armando, Apruzzi, Luca, Palumbo, Diego, Campochiaro, Corrado, Tassan Din, Chiara, Danise, Anna, Da Prat, Valentina, Vitali, Giordano, Brugliera, Luigia, Poli, Andrea, Monardo, Roberta, Monti, Giacomo, Baccellieri, Domenico, De Cobelli, Francesco, Clementi, Massimo, Iannaccone, Sandro, Dagna, Lorenzo, Rovere-Querini, Patrizia, Ciceri, Fabio, Tresoldi, Moreno, Zangrillo, Alberto, Scarpellini, Paolo, Castagna, Antonella, Andolina, Andrea, Bigoloni, Alba, Bossolasco, Simona, Bruzzesi, Elena, Canetti, Diana, Castiglioni, Barbara, Cernuschi, Massimo, Chiurlo, Matteo, Cinque, Paola, Dell’Acqua, Raffaele, Della Torre, Liviana, Gianotti, Nicola, Guffanti, Monica, Hasson, Hamid, Messina, Emanuela, Morsica, Giulia, Nozza, Silvia, Ranzenigo, Martina, Uberti-Foppa, Caterina, Vinci, Concetta, Badalucco Ciotta, Flavia, Bottanelli, Martina, Clemente, Tommaso, Mainardi, Ilaria, Mori, Giovanni, Papaioannu Borjesson, Rebecka, Ponta, Giacomo, Muccini, Camilla, Mastrangelo, Andrea, Oltolini, Chiara, Spagnuolo, Vincenzo, Benassi, Luca, Bigai, Giorgia, Bozzolo, Enrica, Borio, Giorgia, Bussolari, Cecilia, Calvisi, Stefania, Canti, Valentina, Castellani, Jacopo, Cavallo, Ludovica, Cilla, Marta, Cinel, Elena, Compagnone, Nicola, D’Aliberti, Teresa, Damanti, Sarah, De Lorenzo, Rebecca, Di Lucca, Giuseppe, Di Terlizzi, Gaetano, Dumea, Iulia, Farolfi, Federica, Ferrante, Marica, Frangi, Claudia, Gallina, Gabriele, Germinario Bruno, Nicolò, Lanzillotta, Marco, Li Voti, Raffaele, Marinosci, Alessandro, Martinenghi, Sabina, Memoli, Massimo, Montagna, Marco, Pascali, Maria, Patrizi, Alessandro, Pomaranzi, Chiara, Scotti, Raffaella, Strada, Silvia, Boffini, Nicola, Cavalli, Giulio, Della Torre, Emanuel, De Luca, Giacomo, Farina, Nicola, Moroni, Luca, Ramirez Giuseppe, Alvise, Tomelleri, Alessandro, Azzolini Maria, Luisa, Baiardo Redaelli, Martina, Calabrò Maria, Grazia, Casiraghi Giuseppina, Maria, Dell’Acqua, Antonio, Fresilli, Stefano, Guzzo, Francesca, Landoni, Giovanni, Lombardi, Gaetano, Maimeri, Nicolò, Moizo, Elena, Nisi Francesco, Giuseppe, Oriani, Alessandro, Ortalda, Alessandro, Pasculli, Nicola, Pieri, Marina, Turi, Stefano, Bertoglio, Luca, Bilman, Victor, Carletti, Silvia, Gona, Floriana, Mancini, Nicasio, Della Valle, Patrizia, Molinari, Chiara, Poloniato, Antonella, Lalla, Francesca, Prestifilippo, Dario, Sapienza, Jacopo, and Seghi, Federico

Subjects
pulmonary embolism, Infectious Diseases, Oncology, bacteria, coronavirus, infections, thrombosis
Abstract

BackgroundThis study’s primary aim was to evaluate the impact of thrombotic complications on the development of secondary infections. The secondary aim was to compare the etiology of secondary infections in patients with and without thrombotic complications.MethodsThis was a cohort study (NCT04318366) of coronavirus disease 2019 (COVID-19) patients hospitalized at IRCCS San Raffaele Hospital between February 25 and June 30, 2020. Incidence rates (IRs) were calculated by univariable Poisson regression as the number of cases per 1000 person-days of follow-up (PDFU) with 95% confidence intervals. The cumulative incidence functions of secondary infections according to thrombotic complications were compared with Gray's method accounting for competing risk of death. A multivariable Fine-Gray model was applied to assess factors associated with risk of secondary infections.ResultsOverall, 109/904 patients had 176 secondary infections (IR, 10.0; 95% CI, 8.8–11.5; per 1000-PDFU). The IRs of secondary infections among patients with or without thrombotic complications were 15.0 (95% CI, 10.7–21.0) and 9.3 (95% CI, 7.9–11.0) per 1000-PDFU, respectively (P = .017). At multivariable analysis, thrombotic complications were associated with the development of secondary infections (subdistribution hazard ratio, 1.788; 95% CI, 1.018–3.140; P = .043). The etiology of secondary infections was similar in patients with and without thrombotic complications.ConclusionsIn patients with COVID-19, thrombotic complications were associated with a high risk of secondary infections.

Published
2022

33. Cardiac implantable electronic device infections: impact of initiation of antimicrobial treatment before or after device removal on microbiological yield

Author

Ponta, Giacomo, primary, Ranzenigo, Martina, additional, Marzi, Alessandra, additional, Oltolini, Chiara, additional, Tassan Din, Chiara, additional, Spagnuolo, Vincenzo, additional, Mazzone, Patrizio, additional, Carletti, Silvia, additional, Mancini, Nicasio, additional, Uberti-Foppa, Caterina, additional, Della Bella, Paolo, additional, Scarpellini, Paolo, additional, Castagna, Antonella, additional, and Ripa, Marco, additional

Published
2023
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34. Natural Flavonoid Derivatives Have Pan-Coronavirus Antiviral Activity

Author

Mori, Mattia, primary, Quaglio, Deborah, additional, Calcaterra, Andrea, additional, Ghirga, Francesca, additional, Sorrentino, Leonardo, additional, Cammarone, Silvia, additional, Fracella, Matteo, additional, D'Auria, Alessandra, additional, Frasca, Federica, additional, Criscuolo, Elena, additional, Clementi, Nicola, additional, Mancini, Nicasio, additional, Botta, Bruno, additional, Antonelli, Guido, additional, Pierangeli, Alessandra, additional, and Scagnolari, Carolina, additional

Published
2023
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35. Antibiotic appropriateness for Gram-negative bloodstream infections: impact of infectious disease consultation

Author

Da Prat, Valentina, primary, Galli, Laura, additional, Cichero, Paola, additional, Castiglioni, Barbara, additional, Oltolini, Chiara, additional, Tassan Din, Chiara, additional, Andolina, Andrea, additional, Bruzzesi, Elena, additional, Poli, Andrea, additional, Moro, Matteo, additional, Mancini, Nicasio, additional, Clementi, Massimo, additional, Tresoldi, Moreno, additional, Castagna, Antonella, additional, Scarpellini, Paolo, additional, and Ripa, Marco, additional

Published
2023
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36. A diet enriched in omega-3 PUFA and inulin prevents type 1 diabetes by restoring gut barrier integrity and immune homeostasis in NOD mice

Author

Lo Conte, Marta, primary, Antonini Cencicchio, Martina, additional, Ulaszewska, Marynka, additional, Nobili, Angelica, additional, Cosorich, Ilaria, additional, Ferrarese, Roberto, additional, Massimino, Luca, additional, Andolfo, Annapaola, additional, Ungaro, Federica, additional, Mancini, Nicasio, additional, and Falcone, Marika, additional

Published
2023
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38. Enteric Microbiome Markers as Early Predictors of Clinical Outcome in Allogeneic Hematopoietic Stem Cell Transplant: Results of a Prospective Study in Adult Patients

Author

Mancini, Nicasio, Greco, Raffaella, Pasciuta, Renée, Barbanti, Maria Chiara, Pini, Giacomo, Morrow, Olivia Beatrice, Morelli, Mara, Vago, Luca, Clementi, Nicola, Giglio, Fabio, Lupo Stanghellini, Maria Teresa, Forcina, Alessandra, Infurnari, Laura, Marktel, Sarah, Assanelli, Andrea, Carrabba, Matteo, Bernardi, Massimo, Corti, Consuelo, Burioni, Roberto, Peccatori, Jacopo, Sormani, Maria Pia, Banfi, Giuseppe, Ciceri, Fabio, and Clementi, Massimo

Published
2017
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42. Levofloxacin prophylaxis vs no prophylaxis in neutropenic patients within an endemic country for carbapenem-resistant GNB

Author

Clerici, Daniela, primary, Galli, Laura, additional, Greco, Raffaella, additional, Lugli, Anna Paola, additional, Erbella, Federico, additional, Ripa, Marco, additional, Tassan Din, Chiara, additional, Nitti, Rosamaria, additional, Giglio, Fabio, additional, Mastaglio, Sara, additional, Lorentino, Francesca, additional, Xue, Elisabetta, additional, Farina, Francesca, additional, Liberatore, Carmine, additional, POLI, ANDREA, additional, Carletti, Silvia, additional, Lupo Stanghellini, Maria Teresa, additional, Carrabba, Matteo Giovanni Giovanni, additional, Assanelli, Andrea Angelo, additional, Ruggeri, Annalisa, additional, Bernardi, Massimo, additional, Corti, Consuelo, additional, Peccatori, Jacopo, additional, Mancini, Nicasio, additional, Scarpellini, Paolo, additional, Ciceri, Fabio, additional, Castagna, Antonella, additional, and Oltolini, Chiara, additional

Published
2022
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46. A Human Stem Cell-Derived Neurosensory–Epithelial Circuitry on a Chip to Model Herpes Simplex Virus Reactivation

Author

Mazzara, Pietro Giuseppe, primary, Criscuolo, Elena, additional, Rasponi, Marco, additional, Massimino, Luca, additional, Muggeo, Sharon, additional, Palma, Cecilia, additional, Castelli, Matteo, additional, Clementi, Massimo, additional, Burioni, Roberto, additional, Mancini, Nicasio, additional, Broccoli, Vania, additional, and Clementi, Nicola, additional

Published
2022
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47. Discovering host protein interactions specific for SARS-CoV-2 RNA genome

Author

Giambruno, Roberto, primary, Zacco, Elsa, additional, Ugolini, Camilla, additional, Vandelli, Andrea, additional, Mulroney, Logan, additional, D’Onghia, Manfredi, additional, Criscuolo, Elena, additional, Castelli, Matteo, additional, Clementi, Nicola, additional, Clementi, Massimo, additional, Mancini, Nicasio, additional, Bonaldi, Tiziana, additional, Gustincich, Stefano, additional, Leonardi, Tommaso, additional, Tartaglia, Gian Gaetano, additional, and Nicassio, Francesco, additional

Published
2022
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