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2. Towards an Interpretable Functional Image-Based Classifier: Dimensionality Reduction of High-Density Diffuse Optical Tomography Data

Author

Srinivasan, Sruthi, Butters, Emilia, Mancini, Flavia, Bale, Gemma, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Nicosia, Giuseppe, editor, Ojha, Varun, editor, La Malfa, Emanuele, editor, La Malfa, Gabriele, editor, Pardalos, Panos M., editor, and Umeton, Renato, editor

Published
2024
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3. A cellular screening platform, stably expressing DENV2 NS5, defines a novel anti-DENV mechanism of action of Apigenin based on STAT2 activation

Author

Acchioni, Chiara, Acchioni, Marta, Mancini, Flavia, Amendola, Antonello, Marsili, Giulia, Tirelli, Valentina, Gwee, Chin Piaw, Chan, Kitti Wing-Ki, Sandini, Silvia, Bisbocci, Monica, Mysara, Mohamed, ElHefnawi, Mahmoud, Sanchez, Massimo, Venturi, Giulietta, Barreca, Maria Letizia, Manfroni, Giuseppe, Bresciani, Alberto, Vasudevan, Subhash G., and Sgarbanti, Marco

Published
2023
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15. Confidence of probabilistic predictions modulates the cortical response to pain

Author

UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience, Mulders, Dounia, Seymour, Ben, Mouraux, André, Mancini, Flavia, UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience, Mulders, Dounia, Seymour, Ben, Mouraux, André, and Mancini, Flavia

Abstract

Pain typically evolves over time and the brain needs to learn this temporal evolution to predict how pain is likely to change in the future and orient behavior. This process is termed temporal statistical learning (TSL). Recently, it has been shown that TSL for pain sequences can be achieved using optimal Bayesian inference, which is encoded in somatosensory processing regions. Here, we investigate whether the confidence of these probabilistic predictions modulates the EEG response to noxious stimuli, using a TSL task. Confidence measures the uncertainty about the probabilistic prediction, irrespective of its actual outcome. Bayesian models dictate that the confidence about probabilistic predictions should be integrated with incoming inputs and weight learning, such that it modulates the early components of the EEG responses to noxious stimuli, and this should be captured by a negative correlation: when confidence is higher, the early neural responses are smaller as the brain relies more on expectations/predictions and less on sensory inputs (and vice versa). We show that participants were able to predict the sequence transition probabilities using Bayesian inference, with some forgetting. Then, we find that the confidence of these probabilistic predictions was negatively associated with the amplitude of the N2 and P2 components of the Vertex Potential: the more confident were participants about their predictions, the smaller was the Vertex Potential. These results confirm key predictions of a Bayesian learning model and clarify the functional significance of the early EEG responses to nociceptive stimuli, as being implicated in confidence-weighted statistical learning.

Published
2023

23. Behavioral evidences and EEG correlates of nociceptive learning

Author

UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience, UCL - SST/ICTM/ELEN - Pôle en ingénierie électrique, Mulders, Dounia, Seymour, Ben, Mouraux, André, Mancini, Flavia, UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience, UCL - SST/ICTM/ELEN - Pôle en ingénierie électrique, Mulders, Dounia, Seymour, Ben, Mouraux, André, and Mancini, Flavia

Published
2022

24. Confidence-weighted nociceptive learning: behavioral evidences and EEG correlates

Author

UCL - SST/ICTM/ELEN - Pôle en ingénierie électrique, UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience, Mulders, Dounia, Seymour, Ben, Mouraux, André, Mancini, Flavia, UCL - SST/ICTM/ELEN - Pôle en ingénierie électrique, UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience, Mulders, Dounia, Seymour, Ben, Mouraux, André, and Mancini, Flavia

Published
2022

31. Consonancias: Una experiencia musicoterapéutica en el ámbito público hospitalario durante la pandemia de COVID-19

Author

Cannarozzo, Verónica, Godetti, Erica, Mancini, Flavia, Moscuzza, Cecilia Andrea, Gonnet, Daniel, and Diaz Abrahan, Veronika Mariana

Subjects
TRABAJADORES DE LA SALUD, purl.org/becyt/ford/5 [https], COVID-19, MUSICOTERAPIA, purl.org/becyt/ford/5.1 [https], SALUD PÚBLICA
Abstract

La pandemia causada por el virus SARS-CoV-2, generó mayores exigencias para quienes se desempeñan en el sistema de salud, con el natural desgaste físico, psíquico y emocional que ello trajo aparejado. En este marco, surgió una vinculación a través de un convenio específico entre la Universidad Nacional de La Plata (UNLP) y el Hospital Interzonal General de Agudos Profesor Dr. Rodolfo Rossi de la ciudad de La Plata, posibilitando a la Cátedra Libre Musicoterapia (CLM), llevar adelante el proyecto “Consonancias" el cual propuso compartir música en la tarea cotidiana de las y los trabajadores del hospital. El propósito del presente relato de experiencia profesional es mostrar el recorrido realizado por el equipo de la CLM en respuesta a la demanda específica del Hospital, evidenciando finalmente las intervenciones realizadas en el ámbito público hospitalario durante la pandemia. e pandemic caused by the SARS-CoV-2 virus, generates greater demands for those who perform in the health system, with the natural physical, psychological and emotional stress that the suit is wearing. Within this framework, a link has arisen through a specific agreement between the Universidad Nacional de La Plata (UNLP) and the Hospital Interzonal General de Agudos Dr. Rodolfo Rossi from La Plata, enabling Cátedra Libre Musicoterapia (CLM) leading to the project “Consonances" with the proposal to share music on the daily routine of hospital workers. e aim of this professional experience report is to show the appeal carried out by the CLM team with the objective of responding to the specific demand of the Hospital, finally showing the interventions carried out in the public hospital environment during the pandemic. A pandemia causada pelo vírus SARS-CoV-2 até o presente momento vem gerando exigências extras para os profissionais do âmbito da Saúde, ocasionando maiores desgastes físicos, psíquicos e emocionais. Neste marco, surgiu a vinculação entre a Universidad Nacional de La Plata (UNLP) e o Hospital Rodolfo Interzonal General de Agudos Rossi, da cidade de La Plata, por meio de convênio específico, possibilitando a Cátedra Livre Musicoterapia (CLM) a executar o projeto “Consonâncias" com a proposta de compartilhar música nas tarefas cotidianas dos funcionários do Hospital. O propósito do presente relato de experiência profissional é mostrar o recorrido realizado pela equipe da CLM com o objetivo de responder às demandas específicas do Hospital, evidenciando as intervenções realizadas no âmbito público durante a pandemia. Fil: Cannarozzo, Verónica. Universidad Nacional de La Plata; Argentina Fil: Godetti, Erica. Universidad Nacional de La Plata; Argentina. Universidad de Buenos Aires; Argentina Fil: Mancini, Flavia. Universidad Nacional de La Plata; Argentina. Universidad de Buenos Aires; Argentina Fil: Moscuzza, Cecilia Andrea. Universidad Nacional de La Plata; Argentina. Universidad de Buenos Aires; Argentina Fil: Gonnet, Daniel. Universidad Nacional de La Plata; Argentina. Universidad de Buenos Aires; Argentina Fil: Diaz Abrahan, Veronika Mariana. Universidad Nacional de La Plata; Argentina. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina

Published
2021

32. Consonancias

Author

Cannarozzo, Verónica, primary, Godetti, Erica, additional, Mancini, Flavia, additional, Moscuzza, Cecilia Andrea, additional, Gonnet, Daniel, additional, and Diaz Abrahan, Verónika, additional

Published
2021
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33. A central mechanism of analgesia in mice and humans lacking the sodium channel NaV1.7

Author

MacDonald, Donald Iain, primary, Sikandar, Shafaq, additional, Weiss, Jan, additional, Pyrski, Martina, additional, Luiz, Ana P., additional, Millet, Queensta, additional, Emery, Edward C., additional, Mancini, Flavia, additional, Iannetti, Gian D., additional, Alles, Sascha R.A., additional, Arcangeletti, Manuel, additional, Zhao, Jing, additional, Cox, James J., additional, Brownstone, Robert M., additional, Zufall, Frank, additional, and Wood, John N., additional

Published
2021
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34. Consonancias: una experiencia musicoterapéutica en el ámbito público hospitalario durante la pandemia de COVID-19

Author

Cannarozzo, Verónica Alejandra, Godetti, Erica, Mancini, Flavia Constanza, Moscuzza, Cecilia, Gonnet, Daniel Horacio, and Diaz Abrahan, Verónika

Subjects
Public health, Trabajadores de la salud, Musicoterapia, COVID-19, Salud, Music therapy, Salud Pública, Health workers
Abstract

La pandemia causada por el virus SARS-CoV-2, generó mayores exigencias para quienes se desempeñan en el sistema de salud, con el natural desgaste físico, psíquico y emocional que ello trajo aparejado. En este marco, surgió una vinculación a través de un convenio específico entre la Universidad Nacional de La Plata (UNLP) y el Hospital Interzonal General de Agudos Profesor Dr. Rodolfo Rossi de la ciudad de La Plata, posibilitando a la Cátedra Libre Musicoterapia (CLM), llevar adelante el proyecto “Consonancias" el cual propuso compartir música en la tarea cotidiana de las y los trabajadores del hospital. El propósito del presente relato de experiencia profesional es mostrar el recorrido realizado por el equipo de la CLM en respuesta a la demanda específica del Hospital, evidenciando finalmente las intervenciones realizadas en el ámbito público hospitalario durante la pandemia., The pandemic caused by the SARS-CoV-2 virus, generates greater demands for those who perform in the health system, with the natural physical, psychological and emotional stress that the suit is wearing. Within this framework, a link has arisen through a specific agreement between the Universidad Nacional de La Plata (UNLP) and the Hospital Interzonal General de Agudos Dr. Rodolfo Rossi from La Plata, enabling Cátedra Libre Musicoterapia (CLM) leading to the project “Consonances" with the proposal to share music on the daily routine of hospital workers. The aim of this professional experience report is to show the appeal carried out by the CLM team with the objective of responding to the specific demand of the Hospital, finally showing the interventions carried out in the public hospital environment during the pandemic., A pandemia causada pelo vírus SARS-CoV-2 até o presente momento vem gerando exigências extras para os profissionais do âmbito da Saúde, ocasionando maiores desgastes físicos, psíquicos e emocionais. Neste marco, surgiu a vinculação entre a Universidad Nacional de La Plata (UNLP) e o Hospital Rodolfo Interzonal General de Agudos Rossi, da cidade de La Plata, por meio de convênio específico, possibilitando a Cátedra Livre Musicoterapia (CLM) a executar o projeto “Consonâncias" com a proposta de compartilhar música nas tarefas cotidianas dos funcionários do Hospital. O propósito do presente relato de experiência profissional é mostrar o recorrido realizado pela equipe da CLM com o objetivo de responder às demandas específicas do Hospital, evidenciando as intervenções realizadas no âmbito público durante a pandemia., Cátedra Libre Musicoterapia

Published
2021

36. Investigations of spatial and temporal aspects of visuo-nociceptive interactions

Author

UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience, UCL - SSH/IPSY - Psychological Sciences Research Institute, UCL - Faculté de psychologie et des sciences de l'éducation, Legrain, Valéry, Collignon, Olivier, Mouraux, André, Berquin, Anne, Farnè, Alessandro, Mancini, Flavia, Manfron, Louise, UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience, UCL - SSH/IPSY - Psychological Sciences Research Institute, UCL - Faculté de psychologie et des sciences de l'éducation, Legrain, Valéry, Collignon, Olivier, Mouraux, André, Berquin, Anne, Farnè, Alessandro, Mancini, Flavia, and Manfron, Louise

Abstract

Studying the mechanisms underlying the perception of a nociceptive stimulus allows to understand how individuals detect and react to potential threats present in their surroundings to protect the integrity of their organism. Notably, the perception of a nociceptive stimulus is affected by the presence of information from other sensory modalities. The aim of this thesis is to explore the impact of a visual stimulus on the activity of the nociceptive system, and more particularly, on the detection thresholds of thermo-nociceptive information transmitted through A-delta and C fibers. The results of the experiments highlight the important role of spatial and temporal relationships between the stimuli of different sensory modalities in improving their interactions., Étudier les mécanismes qui participent à la perception d’une stimulation nociceptive permet de comprendre comment les individus détectent de potentielles menaces présentes dans leur environnement extérieur et y réagissent, afin de protéger l’intégrité de leur organisme. La perception d’une stimulation nociceptive dépend notamment de la présence d’informations appartenant à d’autres modalités sensorielles. L’objectif de cette thèse est d’explorer l’impact d’une stimulation visuelle sur l’activité du système nociceptif, et plus particulièrement, sur les seuils de détection des informations transmises par les fibres A-delta et C. Les résultats des expériences réalisées mettent en évidence l’importance des relations spatiales et temporelles entre les stimuli des différentes modalités sensorielles comme facteurs favorisant leurs interactions., (PSYE - Sciences psychologiques et de l'éducation) -- UCL, 2021

Published
2021

39. Musicoterapia en contexto de encierro : Aportes de la disciplina en el marco de una política socioeducativa

Author

Mancini, Flavia Constanza, Brasesco, Juan Francisco, Cannarozzo, Verónica Alejandra, and Gonnet, Daniel Horacio

Subjects
Musicoterapia, Salud, Interdisciplina, Experiencias artísticas, Contextos de encierro
Abstract

El presente trabajo parte de la descripción de una experiencia interdisciplinaria de intervención realizada durante el año 2017 en las Unidades Penitenciarias de Mujeres N° 8 y 33 del Servicio Penitenciario Bonaerense (SPB); y se propone como fin mostrar cómo, a través de las distintas experiencias musicales y artísticas, pudo construirse un espacio para la emergencia de distintas estéticas y discursos subjetivos, rompiendo así con la lógica del encierro punitivo. En el marco del Programa Centro de Actividades Juveniles (CAJ) se realizaron Talleres de Arte con orientación Música dentro de la Escuela de Educación Media N°19, al interior de las instituciones carcelarias. En ella, mujeres de ambas unidades penales asistían a los talleres coordinados por una Licenciada en Musicoterapia. Cátedra Libre Musicoterapia

Published
2020

42. The mechanism of analgesia in NaV1.7 null mutants

Author

MacDonald, Donald Iain, primary, Sikandar, Shafaq, additional, Weiss, Jan, additional, Pyrski, Martina, additional, Luiz, Ana P., additional, Millet, Queensta, additional, Emery, Edward C., additional, Mancini, Flavia, additional, Iannetti, Gian D., additional, Alles, Sascha R.A., additional, Zhao, Jing, additional, Cox, James J, additional, Brownstone, Robert M., additional, Zufall, Frank, additional, and Wood, John N., additional

Published
2020
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46. Dissociable hormonal profiles for psychopathology and stress in anorexia and bulimia nervosa.

Author

Westwater, Margaret L., Mancini, Flavia, Shapleske, Jane, Serfontein, Jaco, Ernst, Monique, Ziauddeen, Hisham, and Fletcher, Paul C.

Subjects
*HORMONES, *PATHOLOGICAL psychology, *BULIMIA, *DESCRIPTIVE statistics, *ANOREXIA nervosa, *HYDROCORTISONE
Abstract

Background: Anorexia nervosa (AN) and bulimia nervosa (BN) are complex psychiatric conditions, in which both psychological and metabolic factors have been implicated. Critically, the experience of stress can precipitate loss-of-control eating in both conditions, suggesting an interplay between mental state and metabolic signaling. However, associations between psychological states, symptoms and metabolic processes in AN and BN have not been examined. Methods: Eighty-five women (n = 22 AN binge/purge subtype, n = 33 BN, n = 30 controls) underwent remote salivary cortisol sampling and a 2-day, inpatient study session to examine the effect of stress on cortisol, gut hormones [acyl-ghrelin, peptide tyrosine tyrosine (PYY) and glucagon-like peptide-1] and food consumption. Participants were randomized to either an acute stress induction or control task on each day, and plasma hormones were serially measured before a naturalistic, ad libitum meal. Results: Cortisol-awakening response was augmented in AN but not in BN relative to controls, with body mass index explaining the most variance in post-awakening cortisol (36%). Acute stress increased acyl-ghrelin and PYY in AN compared to controls; however, stress did not alter gut hormone profiles in BN. Instead, a group-by-stress interaction showed nominally reduced cortisol reactivity in BN, but not in AN, compared to controls. Ad libitum consumption was lower in both patient groups and unaffected by stress. Conclusions: Findings extend previous reports of metabolic dysfunction in binge-eating disorders, identifying unique associations across disorders and under stress. Moreover, we observed disrupted homeostatic signaling in AN following psychological stress, which may explain, in part, the maintenance of dysregulated eating in this serious illness. [ABSTRACT FROM AUTHOR]

Published
2021
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47. Fine-grained mapping of cortical somatotopies in chronic complex regional pain syndrome

Author

Mancini, Flavia, Wang, Audrey, Schira, Mark M, Isherwood, Zoey J, McAuley, James, Iannetti, Giandomenico, Sereno, Martin, Moseley, G, Rae, Caroline, Mancini, Flavia, Wang, Audrey, Schira, Mark M, Isherwood, Zoey J, McAuley, James, Iannetti, Giandomenico, Sereno, Martin, Moseley, G, and Rae, Caroline

Abstract

It has long been thought that severe chronic pain conditions, such as complex regional pain syndrome (CRPS), are not only associated with, but even maintained by a reorganization of the somatotopic representation of the affected limb in primary somatosensory cortex (S1). This notion has driven treatments that aim to restore S1 representations in CRPS patients, such as sensory discrimination training and mirror therapy. However, this notion is based on both indirect and incomplete evidence obtained with imaging methods with low spatial resolution. Here, we used fMRI to characterize the S1 representation of the affected and unaffected hand in humans (of either sex) with unilateral CRPS. The cortical area, location, and geometry of the S1 representation of the CRPS hand were largely comparable with those of both the unaffected hand and healthy controls. We found no differential relation between affected versus unaffected hand map measures and clinical measures (pain severity, upper limb disability, disease duration). Thus, if any map reorganization occurs, it does not appear to be directly related to pain and disease severity. These findings compel us to reconsider the cortical mechanisms underlying CRPS and the rationale for interventions that aim to "restore" somatotopic representations to treat pain.SIGNIFICANCE STATEMENT This study shows that the spatial map of the fingers in somatosensory cortex is largely preserved in chronic complex regional pain syndrome (CRPS). These findings challenge the treatment rationale for restoring somatotopic representations in complex regional pain syndrome patients.

Published
2019

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