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18 results on '"Manchio, Jeffrey V."'

1. Galunisertib plus neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer: a single-arm, phase 2 trial

Author

Yamazaki, Tomoko, Gunderson, Andrew J, Gilchrist, Miranda, Whiteford, Mark, Kiely, Maria X, Hayman, Amanda, O'Brien, David, Ahmad, Rehan, Manchio, Jeffrey V, Fox, Nathaniel, McCarty, Kayla, Phillips, Michaela, Brosnan, Evelyn, Vaccaro, Gina, Li, Rui, Simon, Miklos, Bernstein, Eric, McCormick, Mary, Yamasaki, Lena, Wu, Yaping, Drokin, Ashley, Carnahan, Trevor, To, Yy, Redmond, William L, Lee, Brian, Louie, Jeannie, Hansen, Eric, Solhjem, Matthew C, Cramer, Julie, Urba, Walter J, Gough, Michael J, Crittenden, Marka R, and Young, Kristina H

Published
2022
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2. A phase II trial of TGFβ type I receptor inhibitor, galunisertib, plus neoadjuvant chemoradiation in patients with locally advanced rectal cancer.

Author

Young, Kristina Hoot, primary, Gunderson, Andrew J, additional, Gilchrist, Miranda, additional, Whiteford, Mark, additional, Kiely, Maria X, additional, Hayman, Amanda, additional, O'Brien, David P, additional, Ahmad, Rehan, additional, Manchio, Jeffrey V, additional, Brosnan, Evelyn, additional, Vaccaro, Gina M., additional, Li, Rui, additional, Simon, Miklos, additional, McCormick, Mary, additional, Drokin, Ashley, additional, Cramer, Julie, additional, Urba, Walter John, additional, Gough, Michael, additional, Crittenden, Marka R., additional, and Yamazaki, Tomoko, additional

Published
2022
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4. The Fetal Wound

Author

Weinzweig, Jeffrey, primary, Manchio, Jeffrey V., additional, Khorsandi, Christopher, additional, Stelnicki, Eric J., additional, and Longaker, Michael T., additional

Published
2010
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5. Contributors

Author

Afifi, Ghada Y., primary, Akelman, Edward, additional, Argenta, Louis C., additional, Arnaud, Eric, additional, Ashmead, Duffield, additional, Aston, Sherrell J., additional, Azari, Kodi K., additional, Azurin, Daniel J., additional, Babbitt, Russell, additional, Baker, Stephen B., additional, Barakat, Nabil A., additional, Barnhill, Raymond L., additional, Barrall, David T., additional, Bartlett, Scott P., additional, Bauer, Bruce S., additional, Bauer, Erik M., additional, Beals, Stephen P., additional, Bentz, Michael L., additional, Beran, Samuel J., additional, Berger, Richard A., additional, Berry, Nada, additional, Biffl, Walter L., additional, Bland, Kirby I., additional, Borud, Loren J., additional, Boyd, Vincent, additional, Breglio, Lynn, additional, Bryan, David J., additional, Buchman, Steven R., additional, Buncke, Harry J., additional, Buntic, Rudolf, additional, Burke, Renee, additional, Burton, Richard I., additional, Caldamone, Anthony A., additional, Calfee, Ryan P., additional, Campbell, Chris A., additional, Carlson, Lois, additional, Caterson, Stephanie A., additional, Cavaliere, Christi M., additional, Chang, Eric I-Yun, additional, Chen, Joyce C., additional, Childers, Ben J., additional, Chin, Gloria A., additional, Chin, Simon H., additional, Christopoulos, Niki A., additional, Cioffi, William G., additional, Coan, Brian S., additional, Cohen, Marilyn A., additional, Cohen, Mimis, additional, Daane, Stephen, additional, David, David J., additional, de la Torre, Jorge I., additional, DeFranzo, Anthony J., additional, Dellon, A. Lee, additional, DeRosa, Jaimie, additional, DiEdwardo, Christine A., additional, Disa, Joseph J., additional, Doherty, Sean T., additional, Dolezal, Rudolph F., additional, Dufresne, Raymond G., additional, Dumontier, Christian, additional, Dunn, Raymond M., additional, Edstrom, Lee E., additional, Eshbaugh, W.G., additional, Evans, Gregory R.D., additional, Fearon, Jeffrey A., additional, Figueroa, Alvaro A., additional, Fisher, Jack, additional, Fix, R. Jobe, additional, Fletcher, James W., additional, Flowers, Robert S., additional, Forrest, Christopher R., additional, Freeman, M. Brandon, additional, Friedland, Jack A., additional, Frye, Karen E., additional, Gastman, Brian R., additional, Gilula, Louis A., additional, Gonzales, Mark H., additional, Goodrich, James T., additional, Gorantla, Vijay S., additional, Gorney, Mark, additional, Granick, Mark S., additional, Greene, Arin K., additional, Greenwald, Joshua A., additional, Gruss, Joseph S., additional, Gupta, Punita, additional, Gurtner, Geoffrey C., additional, Halikis, Mark N., additional, Hallock, Geoffrey G., additional, Halvorson, Eric G., additional, Hammond, Dennis C., additional, Hammond, Rebecca J.B., additional, Harris, Albert R., additional, Harshbarger, Raymond J., additional, Havlik, Robert J., additional, Heinz, Tad R., additional, Hentz, Vincent R., additional, Hickey, Rosemary, additional, Hollier, Larry, additional, Hong, Roy W., additional, Hoy, Erik A., additional, Hsu, Andrew, additional, Hunter-Yates, Jennifer, additional, Jackson, Ian T., additional, Jacob, Lisa M., additional, Jain, Sonu A., additional, Janevicius, Raymond V., additional, Jiang, Shao, additional, Jupiter, Jesse B., additional, Kang, Lana, additional, Kapur, Girish B., additional, Karamikian, Joseph, additional, Kawamoto, Henry K., additional, Kerrigan, Carolyn L., additional, Khorsandi, Christopher, additional, Khuthaila, Dana K., additional, Kim, David C., additional, Kline, Jon, additional, Koudela, Cynthia L., additional, Krizek, Thomas J., additional, Kwan, Matthew D., additional, Lam, Albert, additional, Langstein, Howard N., additional, LaRossa, Don, additional, Laub, Donald R., additional, Le, Jonathan L., additional, Lee, Raphael C., additional, Lee, W.P. Andrew, additional, Lenhart, Dennis E., additional, Levin, L. Scott, additional, Lichtman, David M., additional, Lilley, James, additional, Lin, Kant Y., additional, Little, John William, additional, Longaker, Michael T., additional, Loos, Matthew S., additional, Losee, Joseph E., additional, Luterman, Arnold, additional, Lynch, Sheilah A., additional, Mackinnon, Susan E., additional, Maffi, Terry R., additional, Mahoney, Eric J., additional, Makki, Ahmed Seif, additional, Manchio, Jeffrey V., additional, Manders, Ernest K., additional, Mankani, Mahesh H., additional, Manson, Paul N., additional, Marchac, Daniel, additional, Marks, Malcolm W., additional, Martin, William J., additional, Martineau, Paul A., additional, Mathes, Stephen J., additional, Maxwell, G. Patrick, additional, McCarthy, Joseph G., additional, McClellan, William T., additional, McConnell, Michael P., additional, McFarlane, Robert M., additional, McGrath, Mary H., additional, McQuiston, Leslie T., additional, Mehan, Vineet, additional, Mehta, Anjali R., additional, Melchior, Julie A., additional, Menard, Robert M., additional, Menick, Frederick, additional, Mihm, Martin C., additional, Millard, D. Ralph, additional, Molina, Fernando, additional, Monasterio, Fernando Ortiz, additional, Morales, Louis, additional, Morin, Robert J., additional, Mudgal, Chaitanya S., additional, Mulliken, John B., additional, Mustoe, Thomas A., additional, Myers, Jeffrey N., additional, Nahabedian, Maurice Y., additional, Neumeister, Michael W., additional, Newport, Mary Lynn, additional, Niazi, Zahid, additional, Obaid, Sacha, additional, Olbricht, Suzanne, additional, Omulepu, Osak, additional, Pandya, Sonal, additional, Pantaloni, Marcello, additional, Papay, Frank A., additional, Paresi, Robert J., additional, Patel, Amar, additional, Patel, Jagruti C., additional, Peh, Wilfred C.G., additional, Petro, Jane A., additional, Polley, John W., additional, Poore, Samuel O., additional, Pribaz, Julian J., additional, Ramamurthy, Somayaji, additional, Ramasastry, Sai S., additional, Ramirez, David L., additional, Ramirez, Oscar M., additional, Randall, Peter, additional, Ray, Peter D., additional, Rockwell, W. Bradford, additional, Rodner, Craig M., additional, Rosen, Alan, additional, Rosen, Harvey, additional, Ross, Douglas C., additional, Rozen, Shai, additional, Ruby, Leonard K., additional, Ryu, Jaiyoung, additional, Sacks, Justin M., additional, Salomon, Jhonny, additional, Salyer, Kenneth E., additional, Sandeen, Sven N., additional, Sati, Shawkat, additional, Schneeberger, Stefan, additional, Schnur, David P., additional, Schnur, Paul L., additional, Schultz, Richard C., additional, Schwartzenfeld, David M., additional, Schwarz, Karl A., additional, Seckel, Brooke R., additional, Seki, John T., additional, Senchenkov, Alex, additional, Shashikant, Mark, additional, Shell, Dan H., additional, Shenaq, Saleh M., additional, Shermak, Michele A., additional, Shivapuja, Prasanna-Kumar, additional, Siemionow, Maria, additional, Singh, Davinder J., additional, Slavin, Sumner A., additional, Smith, Eugene M., additional, Sonmez, Erhan, additional, Speziale, Nicholas J., additional, Spira, Melvin, additional, Spolyar, John L., additional, Staffenberg, David A., additional, Stal, Samuel, additional, Stelnicki, Eric J., additional, Stotland, Mitchell A., additional, Strickland, James W., additional, Stromberg, Brent V., additional, Sullivan, Patrick K., additional, Swelstad, Matthew R., additional, Taleisnik, Julio, additional, Taub, Peter J., additional, Tepper, Oren M., additional, Terzis, Julia K., additional, Toriumi, Dean M., additional, Toth, Bryant A., additional, Trumble, Thomas, additional, Tse, Raymond, additional, Tubiana, Raoul, additional, Upton, Joseph, additional, Vásconez, Luis O., additional, Vedder, Nicholas B., additional, Vernadakis, Adam J., additional, Versaci, Armand D., additional, Wagner, William F., additional, Walden, Jennifer L., additional, Wan, Derrick C., additional, Warren, Stephen M., additional, Watson, H. Kirk, additional, Weber, Renata V., additional, Weiland, Andrew J., additional, Weinfeld, Adam B., additional, Weinzweig, Jeffrey, additional, Weinzweig, Norman, additional, Weiss, Arnold-Peter C., additional, Whitaker, Linton A., additional, White, Deborah J., additional, Whitty, Lisa Ann, additional, Wolfe, S. Anthony, additional, Wollstein, Ronit, additional, Woo, Albert S., additional, Wray, R. Christie, additional, Yaremchuk, Michael J., additional, Younai, Soheil S., additional, Yu, Jack C., additional, Yuksel, Eser, additional, Yung, Alarick, additional, Zeikus, Priya S., additional, and Zienowicz, Richard J., additional

Published
2010
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8. Spatiotemporal expression profiling of proteins in rat sciatic nerve regeneration using reverse phase protein arrays

Author

Bryan David J, Litchfield C, Manchio Jeffrey V, Logvinenko Tanya, Holway Antonia H, Austin John, Summerhayes Ian C, and Rieger-Christ Kimberly M

Subjects
Peripheral nerve regeneration, Reverse phase protein array, Extracellular matrix, Proteomics, Growth factors, Cytology, QH573-671
Abstract

Abstract Background Protein expression profiles throughout 28 days of peripheral nerve regeneration were characterized using an established rat sciatic nerve transection injury model. Reverse phase protein microarrays were used to identify the spatial and temporal expression profile of multiple proteins implicated in peripheral nerve regeneration including growth factors, extracellular matrix proteins, and proteins involved in adhesion and migration. This high-throughput approach enabled the simultaneous analysis of 3,360 samples on a nitrocellulose-coated slide. Results The extracellular matrix proteins collagen I and III, laminin gamma-1, fibronectin, nidogen and versican displayed an early increase in protein levels in the guide and proximal sections of the regenerating nerve with levels at or above the baseline expression of intact nerve by the end of the 28 day experimental course. The 28 day protein levels were also at or above baseline in the distal segment however an early increase was only noted for laminin, nidogen, and fibronectin. While the level of epidermal growth factor, ciliary neurotrophic factor and fibroblast growth factor-1 and -2 increased throughout the experimental course in the proximal and distal segments, nerve growth factor only increased in the distal segment and fibroblast growth factor-1 and -2 and nerve growth factor were the only proteins in that group to show an early increase in the guide contents. As expected, several proteins involved in cell adhesion and motility; namely focal adhesion kinase, N-cadherin and β-catenin increased earlier in the proximal and distal segments than in the guide contents reflecting the relatively acellular matrix of the early regenerate. Conclusions In this study we identified changes in expression of multiple proteins over time linked to regeneration of the rat sciatic nerve both demonstrating the utility of reverse phase protein arrays in nerve regeneration research and revealing a detailed, composite spatiotemporal expression profile of peripheral nerve regeneration.

Published
2012
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10. Construct domain analysis of patient health-related quality of life: physical and mental trajectory profiles following open versus endovascular repair of abdominal aortic aneurysm

Author

Mouawad,Nicolas J, Leichtle,Stefan W, Manchio,Jeffrey V, Lampman,Richard M, Halloran,Brian G, Whitehouse Jr,Walter M, Mouawad,Nicolas J, Leichtle,Stefan W, Manchio,Jeffrey V, Lampman,Richard M, Halloran,Brian G, and Whitehouse Jr,Walter M

Abstract

Nicolas J Mouawad, Stefan W Leichtle, Jeffrey V Manchio, Richard M Lampman, Brian G Halloran, Walter M Whitehouse JrMichigan Heart and Vascular Institute, Saint Joseph Mercy Health System, Ann Arbor, MI, USAPurpose: Many clinical trials comparing the outcomes of open surgical repair (OSR) versus endovascular aneurysm repair (EVAR) for abdominal aortic aneurysms (AAAs) have been conducted, with varying results. Surprisingly, few outcomes studies have closely examined perceived physical and mental health-related quality of life (HRQOL) factors through a validated survey tool. The purpose of this prospective observational study was to describe the trajectory of HRQOL measures, from baseline to 1 year after surgery, in patients undergoing OSR or EVAR for AAA, and to explore for differences in physical and mental composite scores and their construct domains (subscales) using the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36®) tool.Patients and methods: Over an 18-month period, a small sample of patients undergoing elective AAA repair in a community hospital setting were prospectively enrolled. Fifteen patients undergoing OSR and twenty patients undergoing EVAR were studied. Physical and mental HRQOL parameters were assessed using the SF-36.Results: No significant differences in demographic and clinical variables were found between the OSR and EVAR groups. In the multivariable linear models with repeated measures, both groups showed a significant decline in physical health composite scores 30 days after the surgical procedure (P < 0.01). However, although the OSR group showed a statistically significant decline in three of the four physical health domains, the EVAR group declined in only one physical health domain. Only the OSR group showed a significant decline in three of the four mental health domains at 30 days; however, the decline of these domains was not reflected in the group’s mental health composite scores. By 90 days af

Published
2012

17. Contributors

Author

Afifi, Ghada Y., Akelman, Edward, Argenta, Louis C., Arnaud, Eric, Ashmead, Duffield, IV, Aston, Sherrell J., Azari, Kodi K., Azurin, Daniel J., Babbitt, Russell, III, Baker, Stephen B., Barakat, Nabil A., Barnhill, Raymond L., Barrall, David T., Bartlett, Scott P., Bauer, Bruce S., Bauer, Erik M., Beals, Stephen P., Bentz, Michael L., Beran, Samuel J., Berger, Richard A., Berry, Nada, Biffl, Walter L., Bland, Kirby I., Borud, Loren J., Boyd, Vincent, Breglio, Lynn, Bryan, David J., Buchman, Steven R., Buncke, Harry J., Buntic, Rudolf, Burke, Renee, Burton, Richard I., Caldamone, Anthony A., Calfee, Ryan P., Campbell, Chris A., Carlson, Lois, Caterson, Stephanie A., Cavaliere, Christi M., Chang, Eric I-Yun, Chen, Joyce C., Childers, Ben J., Chin, Gloria A., Chin, Simon H., Christopoulos, Niki A., Cioffi, William G., Coan, Brian S., Cohen, Marilyn A., Cohen, Mimis, Daane, Stephen, David, David J., de la Torre, Jorge I., DeFranzo, Anthony J., Dellon, A. Lee, DeRosa, Jaimie, DiEdwardo, Christine A., Disa, Joseph J., Doherty, Sean T., Dolezal, Rudolph F., Dufresne, Raymond G., Jr., Dumontier, Christian, Dunn, Raymond M., Edstrom, Lee E., Eshbaugh, W.G., Jr., Evans, Gregory R.D., Fearon, Jeffrey A., Figueroa, Alvaro A., Fisher, Jack, Fix, R. Jobe, Fletcher, James W., Flowers, Robert S., Forrest, Christopher R., Freeman, M. Brandon, Friedland, Jack A., Frye, Karen E., Gastman, Brian R., Gilula, Louis A., Gonzales, Mark H., Goodrich, James T., Gorantla, Vijay S., Gorney, Mark, Granick, Mark S., Greene, Arin K., Greenwald, Joshua A., Gruss, Joseph S., Gupta, Punita, Gurtner, Geoffrey C., Halikis, Mark N., Hallock, Geoffrey G., Halvorson, Eric G., Hammond, Dennis C., Hammond, Rebecca J.B., Harris, Albert R., Harshbarger, Raymond J., III, Havlik, Robert J., Heinz, Tad R., Hentz, Vincent R., Hickey, Rosemary, Hollier, Larry, Jr., Hong, Roy W., Hoy, Erik A., Hsu, Andrew, Hunter-Yates, Jennifer, Jackson, Ian T., Jacob, Lisa M., Jain, Sonu A., Janevicius, Raymond V., Jiang, Shao, Jupiter, Jesse B., Kang, Lana, Kapur, Girish B., Karamikian, Joseph, Kawamoto, Henry K., Jr., Kerrigan, Carolyn L., Khorsandi, Christopher, Khuthaila, Dana K., Kim, David C., Kline, Jon, Koudela, Cynthia L., Krizek, Thomas J., Kwan, Matthew D., Lam, Albert, Langstein, Howard N., LaRossa, Don, Laub, Donald R., Jr., Le, Jonathan L., Lee, Raphael C., Lee, W.P. Andrew, Lenhart, Dennis E., Levin, L. Scott, Lichtman, David M., Lilley, James, Lin, Kant Y., Little, John William, Longaker, Michael T., Loos, Matthew S., Losee, Joseph E., Luterman, Arnold, Lynch, Sheilah A., Mackinnon, Susan E., Maffi, Terry R., Mahoney, Eric J., Makki, Ahmed Seif, Manchio, Jeffrey V., Manders, Ernest K., Mankani, Mahesh H., Manson, Paul N., Marchac, Daniel, Marks, Malcolm W., Martin, William J., Martineau, Paul A., Mathes, Stephen J., Maxwell, G. Patrick, McCarthy, Joseph G., McClellan, William T., McConnell, Michael P., McFarlane, Robert M., McGrath, Mary H., McQuiston, Leslie T., Mehan, Vineet, Mehta, Anjali R., Melchior, Julie A., Menard, Robert M., Menick, Frederick, Mihm, Martin C., Jr., Millard, D. Ralph, Jr., Molina, Fernando, Monasterio, Fernando Ortiz, Morales, Louis, Jr., Morin, Robert J., Mudgal, Chaitanya S., Mulliken, John B., Mustoe, Thomas A., Myers, Jeffrey N., Nahabedian, Maurice Y., Neumeister, Michael W., Newport, Mary Lynn, Niazi, Zahid, Obaid, Sacha, Olbricht, Suzanne, Omulepu, Osak, Pandya, Sonal, Pantaloni, Marcello, Papay, Frank A., Paresi, Robert J., Jr., Patel, Amar, Patel, Jagruti C., Peh, Wilfred C.G., Petro, Jane A., Polley, John W., Poore, Samuel O., Pribaz, Julian J., Ramamurthy, Somayaji, Ramasastry, Sai S., Ramirez, David L., Ramirez, Oscar M., Randall, Peter, Ray, Peter D., Rockwell, W. Bradford, Rodner, Craig M., Rosen, Alan, Rosen, Harvey, Ross, Douglas C., Rozen, Shai, Ruby, Leonard K., Ryu, Jaiyoung, Sacks, Justin M., Salomon, Jhonny, Salyer, Kenneth E., Sandeen, Sven N., Sati, Shawkat, Schneeberger, Stefan, Schnur, David P., Schnur, Paul L., Schultz, Richard C., Schwartzenfeld, David M., Schwarz, Karl A., Seckel, Brooke R., Seki, John T., Senchenkov, Alex, Shashikant, Mark, Shell, Dan H., IV, Shenaq, Saleh M., Shermak, Michele A., Shivapuja, Prasanna-Kumar, Siemionow, Maria, Singh, Davinder J., Slavin, Sumner A., Smith, Eugene M., Jr., Sonmez, Erhan, Speziale, Nicholas J., Spira, Melvin, Spolyar, John L., Staffenberg, David A., Stal, Samuel, Stelnicki, Eric J., Stotland, Mitchell A., Strickland, James W., Stromberg, Brent V., Sullivan, Patrick K., Swelstad, Matthew R., Taleisnik, Julio, Taub, Peter J., Tepper, Oren M., Terzis, Julia K., Toriumi, Dean M., Toth, Bryant A., Trumble, Thomas, Tse, Raymond, Tubiana, Raoul, Upton, Joseph, III, Vásconez, Luis O., Vedder, Nicholas B., Vernadakis, Adam J., Versaci, Armand D., Wagner, William F., Walden, Jennifer L., Wan, Derrick C., Warren, Stephen M., Watson, H. Kirk, Weber, Renata V., Weiland, Andrew J., Weinfeld, Adam B., Weinzweig, Jeffrey, Weinzweig, Norman, Weiss, Arnold-Peter C., Whitaker, Linton A., White, Deborah J., Whitty, Lisa Ann, Wolfe, S. Anthony, Wollstein, Ronit, Woo, Albert S., Wray, R. Christie, Jr., Yaremchuk, Michael J., Younai, Soheil S., Yu, Jack C., Yuksel, Eser, Yung, Alarick, Zeikus, Priya S., and Zienowicz, Richard J.

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18. Construct domain analysis of patient health-related quality of life: physical and mental trajectory profiles following open versus endovascular repair of abdominal aortic aneurysm.

Author

Mouawad NJ, Leichtle SW, Manchio JV, Lampman RM, Halloran BG, and Whitehouse WM Jr

Abstract

Purpose: Many clinical trials comparing the outcomes of open surgical repair (OSR) versus endovascular aneurysm repair (EVAR) for abdominal aortic aneurysms (AAAs) have been conducted, with varying results. Surprisingly, few outcomes studies have closely examined perceived physical and mental health-related quality of life (HRQOL) factors through a validated survey tool. The purpose of this prospective observational study was to describe the trajectory of HRQOL measures, from baseline to 1 year after surgery, in patients undergoing OSR or EVAR for AAA, and to explore for differences in physical and mental composite scores and their construct domains (subscales) using the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36(®)) tool., Patients and Methods: Over an 18-month period, a small sample of patients undergoing elective AAA repair in a community hospital setting were prospectively enrolled. Fifteen patients undergoing OSR and twenty patients undergoing EVAR were studied. Physical and mental HRQOL parameters were assessed using the SF-36., Results: No significant differences in demographic and clinical variables were found between the OSR and EVAR groups. In the multivariable linear models with repeated measures, both groups showed a significant decline in physical health composite scores 30 days after the surgical procedure (P < 0.01). However, although the OSR group showed a statistically significant decline in three of the four physical health domains, the EVAR group declined in only one physical health domain. Only the OSR group showed a significant decline in three of the four mental health domains at 30 days; however, the decline of these domains was not reflected in the group's mental health composite scores. By 90 days after surgery, both groups were not significantly different from their baseline in physical or mental health composite scores, or in any of their respective physical health domains., Conclusion: In this small sample of patients undergoing AAA repair, EVAR resulted in less physical and emotional decline than OSR in the early postoperative period. However, patients in both groups may return to near baseline status at 90 days.

Published
2013
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