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23 results on '"Mancheño-Corvo, Pablo"'

4. Molecular Biology of Malignant Melanoma

Author

Pons, Mar, Mancheño-Corvo, Pablo, Martín-Duque, Pilar, Quintanilla, Miguel, Back, Nathan, editor, Cohen, Irun R., editor, Lajtha, Abel, editor, Lambris, John D., editor, Paoletti, Rodolfo, editor, and Reichrath, Jörg, editor

Published
2008
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7. Dissecting Allo-Sensitization After Local Administration of Human Allogeneic Adipose Mesenchymal Stem Cells in Perianal Fistulas of Crohn's Disease Patients

Author

Avivar-Valderas, Alvaro, primary, Martín-Martín, Cristina, additional, Ramírez, Cristina, additional, Del Río, Borja, additional, Menta, Ramón, additional, Mancheño-Corvo, Pablo, additional, Ortiz-Virumbrales, Maitane, additional, Herrero-Méndez, Ángel, additional, Panés, Julián, additional, García-Olmo, Damián, additional, Castañer, José Luís, additional, Palacios, Itziar, additional, Lombardo, Eleuterio, additional, Dalemans, Wilfried, additional, and DelaRosa, Olga, additional

Published
2019
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8. Additional file 2: of Endoscopic submucosal injection of adipose-derived mesenchymal stem cells ameliorates TNBS-induced colitis in rats and prevents stenosis

Author

Arranz, Eduardo Martín, Arranz, María Martín, Robredo, Tomás, Mancheño-Corvo, Pablo, Menta, Ramón, Alves, Francisco, Parga, Jose Suárez De, Sanz, Pedro Mora, Rosa, Olga De La, Büscher, Dirk, Lombardo, Eleuterio, and Miguel, Fernando De

Subjects
sense organs, skin and connective tissue diseases
Abstract

Figure S2. The macroscopic damage score correlates with weight change (A) and with endoscopic score (B). (PPTX 2254 kb)

Published
2018
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9. Additional file 3: of Endoscopic submucosal injection of adipose-derived mesenchymal stem cells ameliorates TNBS-induced colitis in rats and prevents stenosis

Author

Arranz, Eduardo Martín, Arranz, María Martín, Robredo, Tomás, Mancheño-Corvo, Pablo, Menta, Ramón, Alves, Francisco, Parga, Jose Suárez De, Sanz, Pedro Mora, Rosa, Olga De La, Büscher, Dirk, Lombardo, Eleuterio, and Miguel, Fernando De

Subjects
digestive system diseases
Abstract

Figure S3. The endoscopic score correlation with the colon length 2. (PPTX 37 kb)

Published
2018
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10. Additional file 1: of Endoscopic submucosal injection of adipose-derived mesenchymal stem cells ameliorates TNBS-induced colitis in rats and prevents stenosis

Author

Arranz, Eduardo Martín, Arranz, María Martín, Robredo, Tomás, Mancheño-Corvo, Pablo, Menta, Ramón, Alves, Francisco, Parga, Jose Suárez De, Sanz, Pedro Mora, Rosa, Olga De La, Büscher, Dirk, Lombardo, Eleuterio, and Miguel, Fernando De

Subjects
sense organs, skin and connective tissue diseases
Abstract

Figure S1. Endoscopic score correlation with weight change at day 1 (A) and 11 (B). (PPTX 2289 kb)

Published
2018
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11. Comparative Analysis between the In Vivo Biodistribution and Therapeutic Efficacy of Adipose-Derived Mesenchymal Stromal Cells Administered Intraperitoneally in Experimental Colitis

Author

Lopez-Santalla, Mercedes, primary, Mancheño-Corvo, Pablo, additional, Escolano, Amelia, additional, Menta, Ramon, additional, Delarosa, Olga, additional, Redondo, Juan, additional, Bueren, Juan, additional, Dalemans, Wilfried, additional, Lombardo, Eleuterio, additional, and Garin, Marina, additional

Published
2018
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12. Biodistribution and Efficacy of Human Adipose-Derived Mesenchymal Stem Cells Following Intranodal Administration in Experimental Colitis

Author

Lopez-Santalla, Mercedes, primary, Mancheño-Corvo, Pablo, additional, Escolano, Amelia, additional, Menta, Ramon, additional, DelaRosa, Olga, additional, Abad, Jose Luis, additional, Büscher, Dirk, additional, Redondo, Juan M., additional, Bueren, Juan A., additional, Dalemans, Wilfried, additional, Lombardo, Eleuterio, additional, and Garin, Marina I., additional

Published
2017
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13. Intralymphatic Administration of Adipose Mesenchymal Stem Cells Reduces the Severity of Collagen-Induced Experimental Arthritis

Author

Mancheño-Corvo, Pablo, primary, Lopez-Santalla, Mercedes, additional, Menta, Ramon, additional, DelaRosa, Olga, additional, Mulero, Francisca, additional, del Rio, Borja, additional, Ramirez, Cristina, additional, Büscher, Dirk, additional, Bueren, Juan A., additional, Lopez-Belmonte, Juan, additional, Dalemans, Wilfried, additional, Garin, Marina I., additional, and Lombardo, Eleuterio, additional

Published
2017
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15. T Lymphocyte Prestimulation Impairs in a Time-Dependent Manner the Capacity of Adipose Mesenchymal Stem Cells to Inhibit Proliferation: Role of Interferon γ, Poly I:C, and Tryptophan Metabolism in Restoring Adipose Mesenchymal Stem Cell Inhibitory Effect

Author

Mancheño-Corvo, Pablo, primary, Menta, Ramón, additional, del Río, Borja, additional, Franquesa, Marcella, additional, Ramírez, Cristina, additional, Hoogduijn, Martin J., additional, DelaRosa, Olga, additional, Dalemans, Wilfried, additional, and Lombardo, Eleuterio, additional

Published
2015
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18. Uveal vs. cutaneous melanoma. Origins and causes of the differences

Author

Belmar-Lopez, Carolina, Mancheño-Corvo, Pablo, Quintanilla, Miguel, Martín-Duque, Pilar, Belmar-Lopez, Carolina, Mancheño-Corvo, Pablo, Quintanilla, Miguel, and Martín-Duque, Pilar

Abstract

Melanoma is a malignant tumour derived from melanocytes (dendritic cells originated from the neural crest and capable to produce melanin synthesis) that could be established on the skin or less frequently on the uvea. The cellular origin from both kind of melanoma seems to be the same but the melanocytes migrates to the epithelia for cutaneous melanoma, while for uveal melanoma, they migrate to mesodermic tissues. Despite the common origin, both melanomas show extreme differences in their metastatic potential, clinical response to treatments, immune response and genetic alterations. We will describe some of those differences in this review. © Feseo 2008.

Published
2008

19. Adipose Mesenchymal Stromal Cell Function Is Not Affected by Methotrexate and Azathioprine

Author

Mancheño-Corvo, Pablo, primary, Franquesa, Marcella, additional, de la Rosa, Olga, additional, Ramírez, Cristina, additional, García-Benzaquén, Leyre, additional, Fernández, Vanessa, additional, Menta, Ramón, additional, Beraza, Aitor, additional, Dalemans, Wilfried, additional, Hoogduijn, Martin J., additional, and Lombardo, Eleuterio, additional

Published
2013
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21. Requirement of IFN-γ–Mediated Indoleamine 2,3-Dioxygenase Expression in the Modulation of Lymphocyte Proliferation by Human Adipose–Derived Stem Cells

Author

DelaRosa, Olga, primary, Lombardo, Eleuterio, additional, Beraza, Aitor, additional, Mancheño-Corvo, Pablo, additional, Ramirez, Cristina, additional, Menta, Ramón, additional, Rico, Laura, additional, Camarillo, Eva, additional, García, Laura, additional, Abad, José Luis, additional, Trigueros, Cesar, additional, Delgado, Mario, additional, and Büscher, Dirk, additional

Published
2009
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23. Requirement of IFN-gamma-mediated indoleamine 2,3-dioxygenase expression in the modulation of lymphocyte proliferation by human adipose-derived stem cells.

Author

DelaRosa O, Lombardo E, Beraza A, Mancheño-Corvo P, Ramirez C, Menta R, Rico L, Camarillo E, García L, Abad JL, Trigueros C, Delgado M, and Büscher D

Subjects
CD4-Positive T-Lymphocytes cytology, CD8-Positive T-Lymphocytes cytology, Cell Proliferation, Dinoprostone metabolism, Flow Cytometry, Hepatocyte Growth Factor metabolism, Humans, Interleukin-10 metabolism, Leukocytes, Mononuclear cytology, Lymphocytes immunology, Nitric Oxide metabolism, Reverse Transcriptase Polymerase Chain Reaction, Tissue Engineering, Transforming Growth Factor beta1 metabolism, Adipocytes cytology, Indoleamine-Pyrrole 2,3,-Dioxygenase metabolism, Interferon-gamma metabolism, Lymphocytes cytology, Mesenchymal Stem Cells cytology
Abstract

Human adipose-derived mesenchymal stem cells (hASCs) are mesenchymal stem cells (MSCs) with reduced immunogenicity and capability to modulate immune responses. Whereas the immunosuppressive activity of bone marrow-MSCs has received considerable attention during the last few years, the specific mechanisms underlying hASC-mediated immunosuppression have been poorly studied. Recent studies comparing both cell types have reported differences at transcriptional and proteomic levels, suggesting that hASCs and bone marrow-MSCs, while having similarities, are quite different. This suggests that different mechanisms of immunosuppression may apply. Here, we report that hASCs inhibit peripheral blood mononuclear cells (PBMCs), and CD4(+) and CD8(+) T cell proliferation in both cell-cell contact and transwell conditions, which is accompanied by a reduction of proinflammatory cytokines. We demonstrate that hASCs do not constitutively express immunomodulatory factors. Conditioned supernatants from hASCs stimulated by IFN-gamma, PBMCs, or activated PBMCs highly inhibited PBMC proliferation, indicating that inhibitory factors are released upon hASC activation. Many factors have been involved in MSC-mediated immunosuppression, including IFN-gamma, IL-10, hepatocyte growth factor, prostaglandin E2, transforming growth factor-beta1, indoleamine 2,3-dioxygenase (IDO), nitric oxide, and IL-10. Using pharmacological inhibitors, neutralizing antibodies, and genetically modified hASCs that constitutively express or silence IDO enzyme, we demonstrate that, in the case of hASCs, the IFN-gamma/IDO axis is essential. Taken together, our data support the key role of IDO in the therapeutic use of hASC on immunomediated diseases.

Published
2009
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