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2,721 results on '"Man, S."'

1. Aging and putative frailty biomarkers are altered by spaceflight

Author

Camera, Andrea, Tabetah, Marshall, Castañeda, Veronica, Kim, JangKeun, Galsinh, Aman Singh, Haro-Vinueza, Alissen, Salinas, Ivonne, Seylani, Allen, Arif, Shehbeel, Das, Saswati, Mori, Marcelo A., Carano, Anthony, de Oliveira, Lorraine Christine, Muratani, Masafumi, Barker, Richard, Zaksas, Victoria, Goel, Chirag, Dimokidis, Eleni, Taylor, Deanne M., Jeong, Jisu, Overbey, Eliah, Meydan, Cem, Porterfield, D. Marshall, Díaz, Juan Esteban, Caicedo, Andrés, Schisler, Jonathan C., Laiakis, Evagelia C., Mason, Christopher E., Kim, Man S., Karouia, Fathi, Szewczyk, Nathaniel J., and Beheshti, Afshin

Published
2024
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3. Aging and putative frailty biomarkers are altered by spaceflight

Author

Andrea Camera, Marshall Tabetah, Veronica Castañeda, JangKeun Kim, Aman Singh Galsinh, Alissen Haro-Vinueza, Ivonne Salinas, Allen Seylani, Shehbeel Arif, Saswati Das, Marcelo A. Mori, Anthony Carano, Lorraine Christine de Oliveira, Masafumi Muratani, Richard Barker, Victoria Zaksas, Chirag Goel, Eleni Dimokidis, Deanne M. Taylor, Jisu Jeong, Eliah Overbey, Cem Meydan, D. Marshall Porterfield, Juan Esteban Díaz, Andrés Caicedo, Jonathan C. Schisler, Evagelia C. Laiakis, Christopher E. Mason, Man S. Kim, Fathi Karouia, Nathaniel J. Szewczyk, and Afshin Beheshti

Subjects
Medicine, Science
Abstract

Abstract Human space exploration poses inherent risks to astronauts’ health, leading to molecular changes that can significantly impact their well-being. These alterations encompass genomic instability, mitochondrial dysfunction, increased inflammation, homeostatic dysregulation, and various epigenomic changes. Remarkably, these changes bear similarities to those observed during the aging process on Earth. However, our understanding of the connection between these molecular shifts and disease development in space remains limited. Frailty syndrome, a clinical syndrome associated with biological aging, has not been comprehensively investigated during spaceflight. To bridge this knowledge gap, we leveraged murine data obtained from NASA’s GeneLab, along with astronaut data gathered from the JAXA and Inspiration4 missions. Our objective was to assess the presence of biological markers and pathways related to frailty, aging, and sarcopenia within the spaceflight context. Through our analysis, we identified notable changes in gene expression patterns that may be indicative of the development of a frailty-like condition during space missions. These findings suggest that the parallels between spaceflight and the aging process may extend to encompass frailty as well. Consequently, further investigations exploring the utility of a frailty index in monitoring astronaut health appear to be warranted.

Published
2024
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6. Aiouea padiformis extract exhibits anti-inflammatory effects by inhibiting the ATPase activity of NLRP3

Author

Sumin Lee, Qianying Ye, Hyeyun Yang, Sojung Lee, YeJi Kim, Nahyun Lee, Darwin Gonzalez-Cox, Dong-Keun Yi, Soo-Yong Kim, Sangho Choi, Taesoo Choi, Man S. Kim, Seong Su Hong, Chun Whan Choi, Yoonsung Lee, and Yong Hwan Park

Subjects
NLRP3 inflammasome, Anti-inflammation, Plant extracts, Aiouea padiformis, Lauraceae, Medicine, Science
Abstract

Abstract Inflammation is implicated as a cause in many diseases. Most of the anti-inflammatory agents in use are synthetic and there is an unmet need for natural substance-derived anti-inflammatory agents with minimal side effects. Aiouea padiformis belongs to the Lauraceae family and is primarily found in tropical regions. While some members of the Aiouea genus are known to possess anti-inflammatory properties, the anti-inflammatory properties of Aiouea padiformis extract (AP) have not been investigated. In this study, we aimed to examine the anti-inflammatory function of AP through the NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome and elucidate the underlying mechanisms. Treatment with AP inhibited the secretion of interleukin-1 beta (IL-1β) mediated by NLRP3 inflammasome in J774A.1 and THP-1 cells without affecting the viability. In addition, AP treatment did not influence NF-κB signaling, potassium efflux, or intracellular reactive oxygen species (ROS) production—all of which are associated with NLRP3 inflammasome activation. However, intriguingly, AP treatment significantly reduced the ATPase activity of NLRP3, leading to the inhibition of ASC oligomerization and speck formation. Consistent with cellular experiments, the anti-inflammatory property of AP in vivo was also evaluated using an LPS-induced inflammation model in zebrafish, demonstrating that AP hinders NLRP3 inflammasome activation.

Published
2024
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7. Bounds for Kloosterman sums on GL(n)

Author

Blomer, V. and Man, S. H.

Subjects
Mathematics - Number Theory
Abstract

This paper establishes power-saving bounds for Kloosterman sums associated with the long Weyl element for GL(n), as well as for another type of Weyl element of order 2. These bounds are obtained by establishing an explicit representation as exponential sums. As an application we go beyond Sarnak's density conjecture for the principal congruence subgroup of prime level. We also bound all Kloosterman sums for GL(4)., Comment: some updates; to appear in Math. Ann

Published
2022

8. Postoperative risk assessment of post-inflammatory hyperpigmentation and the efficacy of delayed prevention following 532 nm Q-switched Nd:YAG laser treatment of solar lentigines: a randomized controlled study

Author

Da-Hyun Kang, Sang-min Choi, Yoonsung Lee, Man S. Kim, Bark-Lynn Lew, and Soon-Hyo Kwon

Subjects
Post-inflammatory hyperpigmentation, prevention, Q-switched Nd:YAG, risk assessment, solar lentigo, triple combination cream, Dermatology, RL1-803
Abstract

Background Although post-inflammatory hyperpigmentation (PIH) is a common adverse event following laser procedures, studies evaluating its risk remain limited.Objective To analyze PIH risk after 532 nm Q-switched Nd:YAG laser (QSNYL) treatment for solar lentigines and examine the efficacy of triple combination cream (TCC) for its prevention.Methods In this single center, investigator-blinded, randomized controlled study, participants with solar lentigo either received TCC or emollient from 2 weeks post-QSNYL treatment. The occurrence of PIH was determined by three independent and blinded dermatologists. In vivo skin measurements and sun exposure questionnaires were examined to evaluate the risk of PIH.Results A total of 28 patients with 67 solar lentigines were included in the analysis. In the control group, PIH occurred in 55.3% of the lesions. Risk factors for the occurrence of PIH were the increased erythema at weeks 2 (OR, 1.32; p = 0.035) and outdoor activity during 1–5 pm (OR, 8.10; p = 0.038). Treatment with TCC from 2 weeks post-QSNYL treatment significantly decreased the incidence of PIH (31.0% vs. 55.3%, p = 0.048).Conclusion Post-laser erythema and outdoor activity at the daytime are prognostic factors for the occurrence of PIH. Administering TCC could be considered for the prevention of PIH in high-risk patients.

Published
2024
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9. Clinical Performance of a Dedicated Urine-Based Assay for the Detection of Human Papillomavirus and Cervical Intraepithelial Neoplasia

Author

Zhao Y, Zhao L, Wang Z, Cui S, Ren C, Yang L, Bai Y, Zhu Y, Xie J, Li Y, Wu X, Feng J, Man S, Huang L, Li X, Yu X, and Wang J

Subjects
hpv testing, cervical intraepithelial neoplasia, diagnostic test accuracy, human papillomavirus, urine, Gynecology and obstetrics, RG1-991
Abstract

Yun Zhao,1,* Lijun Zhao,1,* Zhaohuang Wang,1 Shuhui Cui,1 Chenchen Ren,2 Li Yang,2 Yang Bai,2 Yuanhang Zhu,2 Jingyan Xie,3 Yujuan Li,3 Xiaoqing Wu,3 Jing Feng,3 Shanqing Man,4 Longmei Huang,4 Xiaoqi Li,4 Xiaotian Yu,4 Jianliu Wang1 1Department of Obstetrics and Gynecology, Peking University People’s Hospital, Beijing, People’s Republic of China; 2Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, National Clinical Research Center for Obstetrics and Gynecology, Zhengzhou Key Laboratory of Cervical Disease, Zhengzhou Key Laboratory of Endometrial Disease Prevention and Treatment, Zhengzhou, Henan, People’s Republic of China; 3Department of Obstetrics and Gynecology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China; 4Hangzhou New Horizon Health Technology Co. Ltd, Hangzhou, Zhejiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jianliu Wang, Department of Obstetrics and Gynecology, Peking University People’s Hospital, 11 Xizhimen South Street, Xicheng District, Beijing, 100044, People’s Republic of China, Tel +8618901086568, Email wangjianliu1203@163.comObjective: The objective of this study is to assess the clinical performance of a urine-based high-risk human papillomavirus (hrHPV) test for the detection of cervical intraepithelial neoplasia grade 2 or higher (CIN2+).Methods: Between September and December 2021, women aged 20 to 65 years referred to colposcopy clinic were prospectively recruited at three clinical centers in China. Paired urine and cervical specimens from all enrolled women were obtained for hrHPV DNA fluorescence quantitative PCR test. The results of liquid-based cytology (LBC), colposcopy and diagnostic biopsies were collected. We evaluated the sensitivity and specificity for CIN and assessed the agreement/kappa value.Results: A total of 732 women (median age, 40 years) with valid results were included in the study, and 130 (17.8%) women were histologically confirmed as CIN2+. The sensitivity of urine and cervical test for CIN2+ and CIN3+ were 87.69% and 85.45%, respectively. The specificity of urine test performed better than cervical test in women with

Published
2023

11. Microbial dysbiosis and the host airway epithelial response: insights into HIV-associated COPD using multi’omics profiling

Author

Jude, Marcia Smiti, Yang, Chen Xi, Filho, Fernando Studart Leitao, Hernandez Cordero, Ana I., Yang, Julia, Shaipanich, Tawimas, Li, Xuan, Lin, David, MacIsaac, Julie, Kobor, Michael S., Sinha, Sunita, Nislow, Corey, Singh, Amrit, Lam, Wan, Lam, Stephen, Guillemi, Silvia, Harris, Marianne, Montaner, Julio, Ng, Raymond T., Carlsten, Christopher, Paul Man, S. F., Sin, Don D., and Leung, Janice M.

Published
2023
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15. Estimated prevalence and trends in smoking among adolescents in South Korea, 2005–2021: a nationwide serial study

Author

Shin, Hyoin, Park, Sangil, Yon, Hyunju, Ban, Chae Yeon, Turner, Stephen, Cho, Seong Ho, Shin, Youn Ho, Shin, Jung U., Koyanagi, Ai, Jacob, Louis, Smith, Lee, Min, Chanyang, Lee, Young Joo, Kim, So Young, Lee, Jinseok, Kwon, Rosie, Koo, Min Ji, Fond, Guillaume, Boyer, Laurent, Hahn, Jong Woo, Kim, Namwoo, Rhee, Sang Youl, Shin, Jae Il, Woo, Ho Geol, Park, Hyeowon, Kim, Hyeon Jin, Lee, Yoonsung, Kim, Man S., Lefkir, Eléa, Hadalin, Vlasta, Choi, Jungwoo, Lee, Seung Won, Yon, Dong Keon, and Kim, Sunyoung

Published
2023
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16. Geographic Variations and the Associated Factors in Adherence to and Persistence with Adjuvant Hormonal Therapy for the Privately Insured women Aged 18–64 with Breast Cancer in Texas

Author

Junghyun Kim, Man S. Kim, Suja S. Rajan, Xianglin L. Du, Luisa Franzini, Tae Gi Kim, Sharon H. Giordano, and Robert O. Morgan

Subjects
geographic variation, adjuvant hormonal therapy, breast cancer, adherence, persistence, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

The purpose of this study is to examine the geographical patterns of adjuvant hormonal therapy adherence and persistence and the associated factors in insured Texan women aged 18–64 with early breast cancer. A retrospective cohort study was conducted using 5-year claims data for the population insured by the Blue Cross Blue Shield of Texas (BCBSTX). Women diagnosed with early breast cancer who were taking tamoxifen or aromatase inhibitors (AIs) for adjuvant hormonal therapy with at least one prescription claim were identified. Adherence to adjuvant hormonal therapy and persistence with adjuvant hormonal therapy were calculated as outcome measures. Women without a gap between two consecutively dispensed prescriptions of at least 90 days were considered to be persistently taking the medications. Patient-level multivariate logistic regression models with repeated regional-level adjustments and a Cox proportional hazards model with mixed effects were used to determine the geographical variations and patient-, provider-, and area-level factors that were associated with adjuvant hormonal therapy adherence and persistence. Of the 938 women in the cohort, 627 (66.8%) initiated adjuvant hormonal therapy. Most of the smaller HRRs have significantly higher or lower rates of treatment adherence and persistence rates relative to the median regions. The use of AHT varies substantially from one geographical area to another, especially for adherence, with an approximately two-fold difference between the lowest and highest areas, and area-level factors were found to be significantly associated with the compliance of AHT. There are geographical variations in AHT adherence and persistence in Texas. Patient-level and area-level factors have significant associations explaining these patterns.

Published
2023
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17. RNA-Seq of an LPS-Induced Inflammation Model Reveals Transcriptional Profile Patterns of Inflammatory Processes

Author

Kisung Sheen, Seokho Myung, Dong-Min Lee, Sanghyeon Yu, Yueun Choi, Taeyoon Kim, Jihan Kim, Sang-Gu Ji, Myung-Seo Kim, Wonnam Kim, Yoonsung Lee, Man S. Kim, and Yeon-Cheol Park

Subjects
LPS-induced inflammation model, whole-blood bulk RNA-seq, core gene list, Science
Abstract

The LPS-induced inflammation model is widely used for studying inflammatory processes due to its cost-effectiveness, reproducibility, and faithful representation of key hallmarks. While researchers often validate this model using clinical cytokine markers, a comprehensive understanding of gene regulatory mechanisms requires extending investigation beyond these hallmarks. Our study leveraged multiple whole-blood bulk RNA-seq datasets to rigorously compare the transcriptional profiles of the well-established LPS-induced inflammation model with those of several human diseases characterized by systemic inflammation. Beyond conventional inflammation-associated systems, we explored additional systems indirectly associated with inflammatory responses (i.e., ISR, RAAS, and UPR) using a customized core inflammatory gene list. Our cross-condition-validation approach spanned four distinct conditions: systemic lupus erythematosus (SLE) patients, dengue infection, candidemia infection, and staphylococcus aureus exposure. This analysis approach, utilizing the core gene list aimed to assess the model’s suitability for understanding the gene regulatory mechanisms underlying inflammatory processes triggered by diverse factors. Our analysis resulted in elevated expressions of innate immune-associated genes, coinciding with suppressed expressions of adaptive immune-associated genes. Also, upregulation of genes associated with cellular stresses and mitochondrial innate immune responses underscored oxidative stress as a central driver of the corresponding inflammatory processes in both the LPS-induced and other inflammatory contexts.

Published
2024
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18. Multi-System-Level Analysis with RNA-Seq on Pterygium Inflammation Discovers Association between Inflammatory Responses, Oxidative Stress, and Oxidative Phosphorylation

Author

Ye-Ah Kim, Yueun Choi, Tae Gi Kim, Jisu Jeong, Sanghyeon Yu, Taeyoon Kim, Kisung Sheen, Yoonsung Lee, Taesoo Choi, Yong Hwan Park, Min Seok Kang, and Man S. Kim

Subjects
pterygium, inflammation, race, RNA sequencing, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

A pterygium is a common conjunctival degeneration and inflammatory condition. It grows onto the corneal surface or limbus, causing blurred vision and cosmetic issues. Ultraviolet is a well-known risk factor for the development of a pterygium, although its pathogenesis remains unclear, with only limited understanding of its hereditary basis. In this study, we collected RNA-seq from both pterygial tissues and conjunctival tissues (as controls) from six patients (a total of twelve biological samples) and retrieved publicly available data, including eight pterygium samples and eight controls. We investigated the intrinsic gene regulatory mechanisms closely linked to the inflammatory reactions of pterygiums and compared Asian (Korea) and the European (Germany) pterygiums using multiple analysis approaches from different perspectives. The increased expression of antioxidant genes in response to oxidative stress and DNA damage implies an association between these factors and pterygium development. Also, our comparative analysis revealed both similarities and differences between Asian and European pterygiums. The decrease in gene expressions involved in the three primary inflammatory signaling pathways—JAK/STAT, MAPK, and NF-kappa B signaling—suggests a connection between pathway dysfunction and pterygium development. We also observed relatively higher activity of autophagy and antioxidants in the Asian group, while the European group exhibited more pronounced stress responses against oxidative stress. These differences could potentially be necessitated by energy-associated pathways, specifically oxidative phosphorylation.

Published
2024
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19. Multi-System-Level Analysis Reveals Differential Expression of Stress Response-Associated Genes in Inflammatory Solar Lentigo

Author

Jisu Jeong, Wonmin Lee, Ye-Ah Kim, Yun-Ji Lee, Sohyun Kim, Jaeyeon Shin, Yueun Choi, Jihan Kim, Yoonsung Lee, Man S. Kim, and Soon-Hyo Kwon

Subjects
solar lentigo, RNA-seq data, inflammation, oxidative stress, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

Although the pathogenesis of solar lentigo (SL) involves chronic ultraviolet (UV) exposure, cellular senescence, and upregulated melanogenesis, underlying molecular-level mechanisms associated with SL remain unclear. The aim of this study was to investigate the gene regulatory mechanisms intimately linked to inflammation in SL. Skin samples from patients with SL with or without histological inflammatory features were obtained. RNA-seq data from the samples were analyzed via multiple analysis approaches, including exploration of core inflammatory gene alterations, identifying functional pathways at both transcription and protein levels, comparison of inflammatory module (gene clusters) activation levels, and analyzing correlations between modules. These analyses disclosed specific core genes implicated in oxidative stress, especially the upregulation of nuclear factor kappa B in the inflammatory SLs, while genes associated with protective mechanisms, such as SLC6A9, were highly expressed in the non-inflammatory SLs. For inflammatory modules, Extracellular Immunity and Mitochondrial Innate Immunity were exclusively upregulated in the inflammatory SL. Analysis of protein–protein interactions revealed the significance of CXCR3 upregulation in the pathogenesis of inflammatory SL. In conclusion, the upregulation of stress response-associated genes and inflammatory pathways in response to UV-induced oxidative stress implies their involvement in the pathogenesis of inflammatory SL.

Published
2024
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20. Expression of AKT1 Related with Clinicopathological Parameters in Clear Cell Renal Cell Carcinoma

Author

Taesoo Choi, Koo Han Yoo, and Man S. Kim

Subjects
carcinoma, renal cell, AKT1 protein, survival analysis, Biology (General), QH301-705.5
Abstract

Pathways such as VEGF, EGF and mTOR are known to be one of the major mechanisms of tumorigenesis including kidney cancer. To identify potential signaling pathway proteins, we performed differential/correlation analyses of mTOR-associated genes from three public datasets. AKT1 protein, one of the PI3K/AKT/mTOR pathways, turned out to be the potential by showing a consistent discrepancy between ccRCC-associated conditions as well as strong correlation with other mTOR-associated genes across the datasets. Then, we analyzed how AKT1 alteration affects clear cell renal cell carcinoma. The pathology of 58 kidney cancer patients was constructed to analyze the relationship between the expression level of AKT1 through immunohistochemical staining and their clinicopathological data. Gender, age and TNM stage did not show significant results. AKT1 is a known oncogene. However, in this study, high expression of AKT1 showed a slight correlation with lower WHO/ISUP grade, longer recurrence-free and progression-free survival rates.

Published
2022
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24. RNA-Seq of an LPS-Induced Inflammation Model Reveals Transcriptional Profile Patterns of Inflammatory Processes

Author

Sheen, Kisung, primary, Myung, Seokho, additional, Lee, Dong-Min, additional, Yu, Sanghyeon, additional, Choi, Yueun, additional, Kim, Taeyoon, additional, Kim, Jihan, additional, Ji, Sang-Gu, additional, Kim, Myung-Seo, additional, Kim, Wonnam, additional, Lee, Yoonsung, additional, Kim, Man S., additional, and Park, Yeon-Cheol, additional

Published
2024
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25. A scoping review of digital fabrication techniques applied to prosthetics and orthotics: Part 1 of 2—Prosthetics

Author

Oldfrey, Ben M., primary, Morgado Ramirez, Dafne Z., additional, Miodownik, Mark, additional, Wassall, Matthew, additional, Ramstrand, Nerrolyn, additional, Wong, Man S., additional, Danemayer, Jamie, additional, Dickinson, Alex, additional, Kenney, Laurence, additional, Nester, Christopher, additional, Lemaire, Edward, additional, Gholizadeth, Hossein, additional, Diment, Laura E., additional, Donovan-Hall, Margaret K., additional, and Holloway, Catherine, additional

Published
2024
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27. Optomechanics with a polarization non-degenerate cavity

Author

Buters, F. M., Weaver, M. J., Eerkens, H. J., Heeck, K., de Man, S., and Bouwmeester, D.

Subjects
Quantum Physics
Abstract

Experiments in the field of optomechanics do not yet fully exploit the photon polarization degree of freedom. Here experimental results for an optomechanical interaction in a polarization nondegenerate system are presented and schemes are proposed for how to use this interaction to perform accurate side-band thermometry and to create novel forms of photon-phonon entanglement. The experimental system utilizes the compressive force in the mirror attached to a mechanical resonator to create a micro-mirror with two radii of curvature which leads, when combined with a second mirror, to a significant polarization splitting of the cavity modes., Comment: 5 pages, 4 figures

Published
2016
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29. Spatial structure and influencing factors of an emerging wine tourism network: A case study of the Ningxia wine region

Author

Gu, Qiushi, Ye, Ben H., Huang, Songshan, Wong, Man S., Wang, Lei, Gu, Qiushi, Ye, Ben H., Huang, Songshan, Wong, Man S., and Wang, Lei

Abstract

Purpose: Networks linking tourist attractions or organizations are a major focus of tourism research. Despite extensive research on tourism networks, academic research on the spatial structure and formation of wine tourism networks is limited. This study aims to investigate the spatial structure and factors influencing the development of a network among Ningxia wineries, an emerging wine tourism destination in China. Design/methodology/approach: This study uses social network analysis to uncover “what” the spatial structure of wine tourism networks looks like. Sixteen in-depth interviews were conducted among key stakeholders to explain the “why” of such structural characteristics. Findings: The results show that in an emerging wine tourism destination, popular tourist attractions enjoy high centrality and hold key positions in the wine tourism network. Small wineries exhibit high closeness centrality, and only one winery serves as a network broker. According to the stakeholders, the importance of network actors will increase as their economic and political importance increase, while small wineries that lack differentiation in the network may perish. Practical implications: Local governments can implement the suggested measures for improving network connections, and wineries are advised to find suitable positions to improve the experiences of tourists. Originality/value: This study pioneers the identification of the distinct structure and factors influencing the network of an emerging wine tourism destination, thus enriching the understanding of the interplay and roles of different actors.

Published
2024

30. A scoping review of digital fabrication techniques applied to prosthetics and orthotics : Part 1 of 2-Prosthetics

Author

Oldfrey, Ben M., Morgado Ramirez, Dafne Z., Miodownik, Mark, Wassall, Matthew, Ramstrand, Nerrolyn, Wong, Man S., Danemayer, Jamie, Dickinson, Alex, Kenney, Laurence, Nester, Christopher, Lemaire, Edward, Gholizadeth, Hossein, Diment, Laura E., Donovan-Hall, Margaret K., Holloway, Catherine, Oldfrey, Ben M., Morgado Ramirez, Dafne Z., Miodownik, Mark, Wassall, Matthew, Ramstrand, Nerrolyn, Wong, Man S., Danemayer, Jamie, Dickinson, Alex, Kenney, Laurence, Nester, Christopher, Lemaire, Edward, Gholizadeth, Hossein, Diment, Laura E., Donovan-Hall, Margaret K., and Holloway, Catherine

Abstract

BACKGROUND: Traditionally, the manufacture of prostheses is time-consuming and labor-intensive. One possible route to improving access and quality of these devices is the digitalizing of the fabrication process, which may reduce the burden of manual labor and bring the potential for automation that could help unblock access to assistive technologies globally. OBJECTIVES: To identify where there are gaps in the literature that are creating barriers to decision-making on either appropriate uptake by clinical teams or on the needed next steps in research that mean these technologies can continue on a pathway to maturity. STUDY DESIGN: Scoping literature review. METHODS: A comprehensive search was completed in the following databases: Allied and Complementary Medicine Database, MEDLINE, Embase, Global Health Archive, CINAHL Plus, Cochrane Library, Web of Science, Association for Computing Machinery, Institute of Electrical and Electronics Engineers, and Engineering Village, resulting in 3487 articles to be screened. RESULTS: After screening, 130 lower limb prosthetic articles and 117 upper limb prosthetic articles were included in this review. Multiple limitations in the literature were identified, particularly a lack of long-term, larger-scale studies; research into the training requirements for these technologies and the necessary rectification processes; and a high range of variance of production workflows and materials which makes drawing conclusions difficult. CONCLUSIONS: These limitations create a barrier to adequate evidence-based decision-making for clinicians, technology developers, and wider policymakers. Increased collaboration between academia, industry, and clinical teams across more of the pathway to market for new technologies could be a route to addressing these gaps.

Published
2024
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35. Aquatic flight inspired propulsion for autonomous underwater vehicles

Author

Man, S. and Boyd, Stephen

Subjects
623.82, VM Naval architecture. Shipbuilding. Marine engineering
Abstract

Modern Autonomous Underwater Vehicle (AUV) technology has a number of limitations and one of these is vehicle manoeuvrability. Conventional flight style AUVs generally have turning circle diameters of five or more vehicle lengths, but most marine animals can turn in under one body length. This shows there is merit in looking at marine animals for inspiration to improve the manoeuvrability of AUVs. Aquatic flight propulsion is one marine animal propulsion strategy that was identified early in the research as having the potential to full fill this role. Aquatic flight propulsion has been studied experimentally in the past, but most of the past research focused in one or two axis aquatic flight (foil pitch and dorsoventral roll). However, marine animal literatures show animal aquatic flight is a three axis problem and there is an additional motion component in anteroposterior yaw. The effect of this yaw motion is not well understood and this will be the focus of this thesis’s research. The effect of aquatic flight yaw motion is investigated using a combination of computation modelling and experimental studies. It found two-axis aquatic flight is better for producing propulsive thrust for most scenarios, but three-axis aquatic flight is useful for producing additional off axis force. In particular, the three axis slanted foil actuation path can produce a sizeable vertical force with very little change to the horizontal thrust coefficient, which would be very useful for a positively buoyant AUV to control its depth. The experiment verified the model’s results and many of the experiment data points were within 30% of the model prediction. The experiment has a relatively large uncertainty due to turbulences in the recirculating water channel, so 30% is a reasonably good fit. Whilst there is room for improvement for both the model and the experiment, the current model is sufficient to produce provisional estimates for actuator and control system design as well as identification of various cases of interest for further in depth analysis.

Published
2015

40. Penumbral imaging and functional outcome in patients with anterior circulation ischaemic stroke treated with endovascular thrombectomy versus medical therapy: a meta-analysis of individual patient-level data

Author

Berkhemer, Olvert A, Fransen, Puck SS, Beumer, Debbie, van den Berg, Lucie A, Lingsma, Hester F, Yoo, Albert J, Schonewille, Wouter J, Vos, Jan Albert, Nederkoorn, Paul J, Wermer, Marieke JH, van Walderveen, Marianne AA, Staals, Julie, Hofmeijer, Jeannette, van Oostayen, Jacques A., Lycklama à Nijeholt, Geert J., Boiten, Jelis, Brouwer, Patrick A., Emmer, Bart J., de Bruijn, Sebastiaan F., van Dijk, Lukas C., Kappelle, Jaap, Lo, Rob H, van Dijk, Ewoud J., de Vries, Joost, de Kort, Paul L.M., van Rooij, Willem Jan J., van den Berg, Jan S.P., van Hasselt, Boudewijn A.A.M., Aerden, Leo A.M., Dallinga, René J., Visser, Marieke C., Bot, Joseph C.J., Vroomen, Patrick C., Eshghi, Omid, Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Keizer, Koos, Tielbeek, Alexander V., den Hertog, Heleen M., Gerrits, Dick G., van den Berg-Vos, Renske M., Karas, Giorgos B., Steyerberg, Ewout W., Flach, Zwenneke, Marquering, Henk A., Sprengers, Marieke E.S., Jenniskens, Sjoerd F.M., Beenen, Ludo F.M., van den Berg, René, Koudstaal, Peter J., van Zwam, Wim H., Roos, Yvo B.W.E.M., van der Lugt, Aad, van Oostenbrugge, Robert J., Majoie, Charles B.L.M., Dippel, Diederik W.J., Brown, Martin M., Liebig, Thomas, Stijnen, Theo, Andersson, Tommy, Mattle, Heinrich, Wahlgren, Nils, van der Heijden, Esther, Ghannouti, Naziha, Fleitour, Nadine, Hooijenga, Imke, Puppels, Corina, Pellikaan, Wilma, Geerling, Annet, Lindl-Velema, Annemieke, van Vemde, Gina, de Ridder, Ans, Greebe, Paut, de Bont-Stikkelbroeck, José, de Meris, Joke, Janssen, Kirsten, Struijk, Willy, Licher, Silvan, Boodt, Nikki, Ros, Adriaan, Venema, Esmee, Slokkers, Ilse, Ganpat, Raymie-Jayce, Mulder, Maxim, Saiedie, Nawid, Heshmatollah, Alis, Schipperen, Stefanie, Vinken, Stefan, van Boxtel, Tiemen, Koets, Jeroen, Boers, Merel, Santos, Emilie, Borst, Jordi, Jansen, Ivo, Kappelhof, Manon, Lucas, Marit, Geuskens, Ralph, Barros, Renan Sales, Dobbe, Roeland, Csizmadia, Marloes, Hill, MD, Goyal, M, Demchuk, AM, Menon, BK, Eesa, M, Ryckborst, KJ, 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Published
2019
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41. Measurement of the Casimir force with a ferrule-top sensor

Author

Zuurbier, P., de Man, S., Gruca, G., Heeck, K., and Iannuzzi, D.

Subjects
Quantum Physics, Physics - Instrumentation and Detectors
Abstract

We present a Casimir force setup based on an all-optical ferrule-top sensor. We demonstrate that the instrument can be used to measure the gradient of the Casimir force between a gold coated sphere and a gold coated plate with results that are comparable to those achieved by similar atomic force microscope experiments. Thanks to the monolithic design of the force sensor (which does not require any optical triangulation readout) and to the absence of electronics on the sensing head, the instrument represents a significant step ahead for future studies of the Casimir effect under engineered conditions, where the intervening medium or the environmental conditions might be unsuitable for the use of more standard setups.

Published
2011
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42. Halving the Casimir force with conductive oxides

Author

de Man, S., Heeck, K., Wijngaarden, R. J., and Iannuzzi, D.

Subjects
Quantum Physics
Abstract

The possibility to modify the strength of the Casimir effect by tailoring the dielectric functions of the interacting surfaces is regarded as a unique opportunity in the development of Micro- and NanoElectroMechanical Systems. In air, however, one expects that, unless noble metals are used, the electrostatic force arising from trapped charges overcomes the Casimir attraction, leaving no room for exploitation of Casimir force engineering at ambient conditions. Here we show that, in the presence of a conductive oxide, the Casimir force can be the dominant interaction even in air, and that the use of conductive oxides allows one to reduce the Casimir force up to a factor of 2 when compared to noble metals., Comment: modified version, accepted for publication in Phys Rev Lett

Published
2009
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44. Multi-System-Level Analysis with RNA-Seq on Pterygium Inflammation Discovers Association between Inflammatory Responses, Oxidative Stress, and Oxidative Phosphorylation.

Author

Kim, Ye-Ah, Choi, Yueun, Kim, Tae Gi, Jeong, Jisu, Yu, Sanghyeon, Kim, Taeyoon, Sheen, Kisung, Lee, Yoonsung, Choi, Taesoo, Park, Yong Hwan, Kang, Min Seok, and Kim, Man S.

Subjects
OXIDATIVE phosphorylation, PTERYGIUM, INFLAMMATION, RNA sequencing, NF-kappa B, DNA damage, OXIDATIVE stress
Abstract

A pterygium is a common conjunctival degeneration and inflammatory condition. It grows onto the corneal surface or limbus, causing blurred vision and cosmetic issues. Ultraviolet is a well-known risk factor for the development of a pterygium, although its pathogenesis remains unclear, with only limited understanding of its hereditary basis. In this study, we collected RNA-seq from both pterygial tissues and conjunctival tissues (as controls) from six patients (a total of twelve biological samples) and retrieved publicly available data, including eight pterygium samples and eight controls. We investigated the intrinsic gene regulatory mechanisms closely linked to the inflammatory reactions of pterygiums and compared Asian (Korea) and the European (Germany) pterygiums using multiple analysis approaches from different perspectives. The increased expression of antioxidant genes in response to oxidative stress and DNA damage implies an association between these factors and pterygium development. Also, our comparative analysis revealed both similarities and differences between Asian and European pterygiums. The decrease in gene expressions involved in the three primary inflammatory signaling pathways—JAK/STAT, MAPK, and NF-kappa B signaling—suggests a connection between pathway dysfunction and pterygium development. We also observed relatively higher activity of autophagy and antioxidants in the Asian group, while the European group exhibited more pronounced stress responses against oxidative stress. These differences could potentially be necessitated by energy-associated pathways, specifically oxidative phosphorylation. [ABSTRACT FROM AUTHOR]

Published
2024
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46. Anti-inflammatory effect of Aiouea padiformis extract via inhibition of the ATPase activity of NLRP3

Author

Lee, Sumin, primary, Ye, Qianying, additional, Yang, Hyeyun, additional, Lee, Sojung, additional, Kim, YeJi, additional, Lee, Nahyun, additional, Cox, Darwin, additional, Yi, Dong-Keun, additional, Kim, Soo-Yong, additional, Choi, Sangho, additional, Choi, Taesoo, additional, Kim, Man S, additional, Lee, Yoonsung, additional, and Park, Yong Hwan, additional

Published
2023
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49. Isolation and Characterization of Dominant Fungi from Rhizospheric Soil of Saussurea obvallata (DC.) Edgew. (Brahma Kamal) of the Indian Himalayan Region

Author

Debasis Mitra, Anju Rani, Lok Man S. Palni, Komal Sharma, Navendra Uniyal, Akansha Chauhan, Prabhakar Semwal, and Poonam Arya

Subjects
saussurea obvallata, aspergillus fumigatus, phanerochaete chrysosporium, trichoderma longibrachiatum, rhizospheric soil, rdna-its sequencing, Microbiology, QR1-502
Abstract

The Himalayan region is conferred by diverse wealth in term of flora and fauna. Among Himalayan plant biodiversity, Saussurea obvallata (common name Brahma Kamal) has an immense spiritual and medicinal significance. Owing to high demand, this herb is on the verge of extinction. Numerous studies have been carried out for preservation and in vitro regeneration of Saussurea obvallata. In view of above, this is the first study which aims to isolate and identify rhizospheric fungi associated with this plant. Soil samples were collected from three locations in Kedarnath valley and total 34 fungal isolates were isolated. Out of 34, three fungal isolates i.e. MaHaD1, MaHaD2 and MaHaD3 were selected for morphological and molecular characterization. The 16S rDNA sequencing identified MaHaD1, MaHaD2 and MaHaD3 as Phanerochaete chrysosporium, Trichoderma longibrachiatum and Aspergillus fumigatus respectively. The presence of these three dominant fungi in rhizospheric region seems to be results of climatic conditions and plant physiology. Results indicate that the presence of fungal microflora may play a vital role in survival and proliferation of Saussurea obvallata plant by providing tolerance and resistance to abiotic stress and fungal/nematode pathogens respectively.

Published
2019
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50. No anomalous scaling in electrostatic calibrations for Casimir force measurements

Author

de Man, S., Heeck, K., and Iannuzzi, D.

Subjects
Quantum Physics
Abstract

In a recent paper (Phys.Rev.A78, 020101(R) (2008)), Kim at al. have reported a large anomaly in the scaling law of the electrostatic interaction between a sphere and a plate, which was observed during the calibration of their Casimir force set-up. Here we experimentally demonstrate that in proper electrostatic calibrations the scaling law follows the behavior expected from elementary electrostatic arguments, even when the electrostatic voltage that one must apply to minimize the force (typically ascribed to contact potentials) depends on the separation between the surfaces., Comment: Final version

Published
2008
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