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Objective: This research aims to develop a lifestyle intervention system, called MoveSense, that forecasts a patient's activity behavior to allow for early and personalized interventions in real-world clinical environments. Methods: We conducted two clinical studies involving 58 prediabetic veterans and 60 patients with obstructive sleep apnea to gather multimodal behavioral data using wearable devices. We develop multimodal long short-term memory (LSTM) network models, which are capable of forecasting the number of step counts of a patient up to 24 hours in advance by examining data from activity and engagement modalities. Furthermore, we design goal-based forecasting models to predict whether a person's next-day steps will be over a certain threshold. Results: Multimodal LSTM with early fusion achieves 33% and 37% lower mean absolute errors than linear regression and ARIMA respectively on the prediabetes dataset. LSTM also outperforms linear regression and ARIMA with a margin of 13% and 32% on the sleep dataset. Multimodal forecasting models also perform with 72% and 79% accuracy on the prediabetes dataset and sleep dataset respectively on goal-based forecasting. Conclusion: Our experiments conclude that multimodal LSTM models with early fusion are better than multimodal LSTM with late fusion and unimodal LSTM models and also than ARIMA and linear regression models. Significance: We address an important and challenging task of time-series forecasting in uncontrolled environments. Effective forecasting of a person's physical activity can aid in designing adaptive behavioral interventions to keep the user engaged and adherent to a prescribed routine., Comment: 9 pages, 5 figures

Early detection of intrapartum risk enables interventions to potentially prevent or mitigate adverse labor outcomes such as cerebral palsy. Currently, there is no accurate automated system to predict such events to assist with clinical decision-making. To fill this gap, we propose "Artificial Intelligence (AI) for Modeling and Explaining Neonatal Health" (AIMEN), a deep learning framework that not only predicts adverse labor outcomes from maternal, fetal, obstetrical, and intrapartum risk factors but also provides the model's reasoning behind the predictions made. The latter can provide insights into what modifications in the input variables of the model could have changed the predicted outcome. We address the challenges of imbalance and small datasets by synthesizing additional training data using Adaptive Synthetic Sampling (ADASYN) and Conditional Tabular Generative Adversarial Networks (CTGAN). AIMEN uses an ensemble of fully-connected neural networks as the backbone for its classification with the data augmentation supported by either ADASYN or CTGAN. AIMEN, supported by CTGAN, outperforms AIMEN supported by ADASYN in classification. AIMEN can predict a high risk for adverse labor outcomes with an average F1 score of 0.784. It also provides counterfactual explanations that can be achieved by changing 2 to 3 attributes on average. Resources available: https://github.com/ab9mamun/AIMEN., Comment: 17 pages, 8 figures

Particle-producing targets in high-energy research facilities are often made from refractory metals, and they typically require dedicated cooling systems due to the challenging thermomechanical conditions they experience. However, direct contact of water with target blocks can induce erosion, corrosion, and embrittlement, especially of tungsten (W). One approach to overcoming this problem is cladding the blocks with tantalum (Ta). Unfortunately, Ta generates high decay heat when irradiated, raising safety concerns in the event of a loss-of-cooling accident. This study explored the capacity of niobium (Nb) and its alloys to form diffusion bonds with W and TZM (a molybdenum alloy with titanium and zirconium). This is because the Beam Dump Facility (BDF), a planned new fixed-target installation in CERN's North Area, uses these target materials. The bonding quality of pure Nb, Nb1Zr, and C103 (a Nb alloy with 10% hafnium and 1% titanium) with TZM and W obtained using hot isostatic pressing (HIP) was evaluated. The effects of different HIP temperatures and the introduction of a Ta interlayer were examined. Optical microscopy indicated promising bonding interfaces, which were further characterized using tensile tests and thermal-diffusivity measurements. Their performance under high-energy beam impact was validated using thermomechanical simulations. C103 exhibited higher interface strengths and safety factors than Ta2.5W, positioning it as a potential alternative cladding material for the BDF production target. The findings highlight the viability of Nb-based materials, particularly C103, for improving operational safety and efficiency in fixed-target physics experiments; however, considerations regarding the long half-life of 94Nb require further attention.

This study investigates thermal transport across nanocrystalline diamond/AlGaN interfaces, crucial for enhancing thermal management in AlGaN/AlGaN-based devices. Chemical vapor deposition growth of diamond directly on AlGaN resulted in a disordered interface with a high thermal boundary resistance (TBR) of 20.6 m^2-K/GW. We employed sputtered carbide interlayers (e.g., $B_4C$, $SiC$, $B_4C/SiC$) to reduce thermal boundary resistance in diamond/AlGaN interfaces. The carbide interlayers resulted in record-low thermal boundary resistance values of 3.4 and 3.7 m^2-K/GW for Al$_{0.65}$Ga$_{0.35}$N samples with $B_4C$ and $SiC$ interlayers, respectively. STEM imaging of the interface reveals interlayer thicknesses between 1.7-2.5 nm, with an amorphous structure. Additionally, Fast-Fourier Transform (FFT) characterization of sections of the STEM images displayed sharp crystalline fringes in the AlGaN layer, confirming it was properly protected from damage from hydrogen plasma during the diamond growth. In order to accurately measure the thermal boundary resistance we develop a hybrid technique, combining time-domain thermoreflectance and steady-state thermoreflectance fitting, offering superior sensitivity to buried thermal resistances. Our findings underscore the efficacy of interlayer engineering in enhancing thermal transport and demonstrate the importance of innovative measurement techniques in accurately characterizing complex thermal interfaces. This study provides a foundation for future research in improving thermal properties of semiconductor devices through interface engineering and advanced measurement methodologies.

A recent research trend involves treating database index structures as Machine Learning (ML) models. In this domain, single or multiple ML models are trained to learn the mapping from keys to positions inside a data set. This class of indexes is known as "Learned Indexes." Learned indexes have demonstrated improved search performance and reduced space requirements for one-dimensional data. The concept of one-dimensional learned indexes has naturally been extended to multi-dimensional (e.g., spatial) data, leading to the development of "Learned Multi-dimensional Indexes". This survey focuses on learned multi-dimensional index structures. Specifically, it reviews the current state of this research area, explains the core concepts behind each proposed method, and classifies these methods based on several well-defined criteria. We present a taxonomy that classifies and categorizes each learned multi-dimensional index, and survey the existing literature on learned multi-dimensional indexes according to this taxonomy. Additionally, we present a timeline to illustrate the evolution of research on learned indexes. Finally, we highlight several open challenges and future research directions in this emerging and highly active field.

The Center for Disease Control estimates that over 37 million US adults suffer from chronic kidney disease (CKD), yet 9 out of 10 of these individuals are unaware of their condition due to the absence of symptoms in the early stages. It has a significant impact on patients' quality of life, particularly when it progresses to the need for dialysis. Early prediction of dialysis is crucial as it can significantly improve patient outcomes and assist healthcare providers in making timely and informed decisions. However, developing an effective machine learning (ML)-based Clinical Decision Support System (CDSS) for early dialysis prediction poses a key challenge due to the imbalanced nature of data. To address this challenge, this study evaluates various data augmentation techniques to understand their effectiveness on real-world datasets. We propose a new approach named Binary Gaussian Copula Synthesis (BGCS). BGCS is tailored for binary medical datasets and excels in generating synthetic minority data that mirrors the distribution of the original data. BGCS enhances early dialysis prediction by outperforming traditional methods in detecting dialysis patients. For the best ML model, Random Forest, BCGS achieved a 72% improvement, surpassing the state-of-the-art augmentation approaches. Also, we present a ML-based CDSS, designed to aid clinicians in making informed decisions. CDSS, which utilizes decision tree models, is developed to improve patient outcomes, identify critical variables, and thereby enable clinicians to make proactive decisions, and strategize treatment plans effectively for CKD patients who are more likely to require dialysis in the near future. Through comprehensive feature analysis and meticulous data preparation, we ensure that the CDSS's dialysis predictions are not only accurate but also actionable, providing a valuable tool in the management and treatment of CKD.

This study developed a generative adversarial network (GAN)-based defense method for traffic sign classification in an autonomous vehicle (AV), referred to as the attack-resilient GAN (AR-GAN). The novelty of the AR-GAN lies in (i) assuming zero knowledge of adversarial attack models and samples and (ii) providing consistently high traffic sign classification performance under various adversarial attack types. The AR-GAN classification system consists of a generator that denoises an image by reconstruction, and a classifier that classifies the reconstructed image. The authors have tested the AR-GAN under no-attack and under various adversarial attacks, such as Fast Gradient Sign Method (FGSM), DeepFool, Carlini and Wagner (C&W), and Projected Gradient Descent (PGD). The authors considered two forms of these attacks, i.e., (i) black-box attacks (assuming the attackers possess no prior knowledge of the classifier), and (ii) white-box attacks (assuming the attackers possess full knowledge of the classifier). The classification performance of the AR-GAN was compared with several benchmark adversarial defense methods. The results showed that both the AR-GAN and the benchmark defense methods are resilient against black-box attacks and could achieve similar classification performance to that of the unperturbed images. However, for all the white-box attacks considered in this study, the AR-GAN method outperformed the benchmark defense methods. In addition, the AR-GAN was able to maintain its high classification performance under varied white-box adversarial perturbation magnitudes, whereas the performance of the other defense methods dropped abruptly at increased perturbation magnitudes.

We are concerned with a novel Bayesian statistical framework for the characterization of natural subsurface formations, a very challenging task. Because of the large dimension of the stochastic space of the prior distribution in the framework, typically a dimensional reduction method, such as a Karhunen-Leove expansion (KLE), needs to be applied to the prior distribution to make the characterization computationally tractable. Due to the large variability of properties of subsurface formations (such as permeability and porosity) it may be of value to localize the sampling strategy so that it can better adapt to large local variability of rock properties. In this paper, we introduce the concept of multiscale sampling to localize the search in the stochastic space. We combine the simplicity of a preconditioned Markov Chain Monte Carlo method with a new algorithm to decompose the stochastic space into orthogonal subspaces, through a one-to-one mapping of the subspaces to subdomains of a non-overlapping domain decomposition of the region of interest. The localization of the search is performed by a multiscale blocking strategy within Gibbs sampling: we apply a KL expansion locally, at the subdomain level. Within each subdomain, blocking is applied again, for the sampling of the KLE random coefficients. The effectiveness of the proposed framework is tested in the solution of inverse problems related to elliptic partial differential equations arising in porous media flows. We use multi-chain studies in a multi-GPU cluster to show that the new algorithm clearly improves the convergence rate of the preconditioned MCMC method. Moreover, we illustrate the importance of a few conditioning points to further improve the convergence of the proposed method.

This paper presents an effective few-shot point cloud semantic segmentation approach for real-world applications. Existing few-shot segmentation methods on point cloud heavily rely on the fully-supervised pretrain with large annotated datasets, which causes the learned feature extraction bias to those pretrained classes. However, as the purpose of few-shot learning is to handle unknown/unseen classes, such class-specific feature extraction in pretrain is not ideal to generalize into new classes for few-shot learning. Moreover, point cloud datasets hardly have a large number of classes due to the annotation difficulty. To address these issues, we propose a contrastive self-supervision framework for few-shot learning pretrain, which aims to eliminate the feature extraction bias through class-agnostic contrastive supervision. Specifically, we implement a novel contrastive learning approach with a learnable augmentor for a 3D point cloud to achieve point-wise differentiation, so that to enhance the pretrain with managed overfitting through the self-supervision. Furthermore, we develop a multi-resolution attention module using both the nearest and farthest points to extract the local and global point information more effectively, and a center-concentrated multi-prototype is adopted to mitigate the intra-class sparsity. Comprehensive experiments are conducted to evaluate the proposed approach, which shows our approach achieves state-of-the-art performance. Moreover, a case study on practical CAM/CAD segmentation is presented to demonstrate the effectiveness of our approach for real-world applications., Comment: ICRA 2023

Prescription medications often impose temporal constraints on regular health behaviors (RHBs) of patients, e.g., eating before taking medication. Violations of such medical temporal constraints (MTCs) can result in adverse effects. Detecting and predicting such violations before they occur can help alert the patient. We formulate the problem of modeling MTCs and develop a proof-of-concept solution, ActSafe, to predict violations of MTCs well ahead of time. ActSafe utilizes a context-free grammar based approach for extracting and mapping MTCs from patient education materials. It also addresses the challenges of accurately predicting RHBs central to MTCs (e.g., medication intake). Our novel behavior prediction model, HERBERT , utilizes a basis vectorization of time series that is generalizable across temporal scale and duration of behaviors, explicitly capturing the dependency between temporally collocated behaviors. Based on evaluation using a real-world RHB dataset collected from 28 patients in uncontrolled environments, HERBERT outperforms baseline models with an average of 51% reduction in root mean square error. Based on an evaluation involving patients with chronic conditions, ActSafe can predict MTC violations a day ahead of time with an average F1 score of 0.86.