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6. Tuberculosis: Integrated Studies for a Complex Disease 2050

Author

Rezaei, Nima, Hosseini, Nastaran-Sadat, Saghazadeh, Amene, Fateh, Abolfazl, Duse, Adriano, Ahmad, Aijaz, Braley, Alexander E., Tahta, Alican, Kamboj, Alisha, Khan, Amer Hayat, Coelho, Ana Cláudia, Fuso, Andrea, Varón, Andrés, Trajman, Anete, Saxena, Anil Kumar, Ganeshpurkar, Ankit, Casapao, Anthony M., Tkachenko, Anton, Devnikar, Anushka V., Moshiri, Arfa, Muñoz-Barrutia, Arrate, Dasgupta, Arunava, Natarajan, Arvind, Gupta, Ashish, Coyne, Ashlan J. Kunz, Jordan, Ashly E., Kumar, Ashok, Ergeshov, Atadzhan, Pourakbari, Babak, Joshi, Basant, Chavarro-Portillo, Bibiana, Soto, Carlos Y., Kanipe, Carly, Schmidt, Christiane Mello, Cox, Christophe, Gómez-Cruz, Clara, Cardoso, Claudete Aparecida Araújo, Sant´Anna, Clemax Couto, Johnson, Courtney, Rodríguez-Silva, Cristhian N., Rosales, Cristian, Licona-Cassani, Cuauhtémoc, Fast, Cynthia D., Pérez-Martínez, Damián, Pizzol, Damiano, Perlman, David C., Philips, Dennis, Viveros, Diana, Fisher, Dina A., Butov, Dmytro, Egelund, Eric F., de Igartua, Everest, Bhatt, Garima, Mgode, Georgies, Quaglio, Gianluca, Putoto, Giovanni, Mini, G. K., Thomas-Richardson, Govind, Wylie, Greg, dos Santos Fernandes, Guilherme Felipe, Bermúdez, Gustavo, Quintas, Hélder, Verma, Himanshu, Eoh, Hyungjin, Putera, Ikhwanuliman, Sivokozov, Ilya, Pires, Isabel, Lee, Jae Jin, Lombard, Jason E., dos Santos, Jean Leandro, Zellweger, Jean-Pierre, Thomas-Richardson, Jenu, Lordson, Jinbert, Prates, João Lucas, Cervantes, Jorge, Porcel, José M., Vaquero, Juan José, Prada, Justina, Kamboj, Kamal, Tabbara, Khalid F., Mussie, Kirubel Manyazewal, Patel, Krupesh, Porcel, Laura, Fiebig, Lena, Mohan, Malu, Yadav, Mange Ram, López-R, Marcela, Correia-Neves, Margarida, da Conceição Fontes, Maria, de Fátima Pombo Bazhuni Sant´Anna, Maria, Cañadas-Ortega, Marina, Singh, Meenakshi, Lause, Michael, Maya-Hoyos, Milena, Omrani, Mir Davood, Palmer, Mitchell V., Ahmad, Mohammad Naiyaz, Seid, Mohammed Assen, Chauhan, Monica, Saxena, Mridula, Marimani, Musa, Srinivas, Nanduri, Beyene, Negussie, Arenas, Nelson E., Cardoso, Nicole, Oliveira, Olena, Silakari, Om, Inlamea, Osvaldo, Tanrıverdi, Özgür, Boggiatto, Paola M., Santos, Paola, Mejía-Ponce, Paulina, Soares, Pedro, Sell, Philip, Murumkar, Prashant R., Devanandan, Praveen, Zheng, Qi, Lim, Rachel K., Aurílio, Rafaela Baroni, Ghuge, Rahul B., Barot, Rahul R., Rahul, Puvvada, Ranadheer Chowdary, Duarte, Raquel, Singh, Ravi, Sinha, Richa, La Distia Nora, Rina, Burny, Robert, Zenteno-Cuevas, Roberto, Mali, Sagar, Shoughy, Samir S., Tarashi, Samira, Mishra, Sapna, Malasala, Satyaveni, Mamishi, Setareh, Siadat, Seyed Davar, Choudhary, Shalki, Mahmoudi, Shima, Chopra, Sidharth, Nandi, Sisir, Faisal, Sobia, Goel, Sonu, Huszár, Stanislav, Field, Stephen K., Singh, Sushil Kumar, Rito, Teresa, Butova, Tetiana, Manning, Thomas, van der Werf, Tjip S., Myasoedov, Valeriy, Vásquez, Vanessa, Muthukumar, Vijey Aanandhi, Singh, Vinayak, Hall, Walter A., Hikmahwati, Wandya, Turgut, Yaşar Barış, Thaker, Yatri, Kawabata, Yoshinori, de Reus, Yvette A., and Rezaei, Nima, Editor-in-Chief

Published
2023
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19. Post-discharge follow-up of pediatric COVID-19 patients: insights into serological dynamics.

Author

Mahmoudi, Shima, Pourakbari, Babak, Shahbabaie, Mohammad Ali, Sotoudeh, Maryam, Jafari, Erfaneh, Sadeghi, Reihaneh Hosseinpour, and Mamishi, Setareh

Subjects
MULTISYSTEM inflammatory syndrome in children, COVID-19, CHILD patients, COVID-19 pandemic, ENZYME-linked immunosorbent assay, LYMPHOCYTE count
Abstract

Introduction: Limited data are available regarding SARS-CoV-2 serological response dynamics in pediatric patients with COVID-19, contributing to gaps in our understanding of the immune response in this population. This study aimed to investigate SARS-CoV-2 IgG seropositivity in patients diagnosed with COVID-19 during hospitalization and 2-4 weeks after discharge. Methods: A cohort of patients, consisting of 31 individuals with confirmed acute COVID-19 infection and 27 diagnosed with Multisystem Inflammatory Syndrome in Children (MIS-C), was enrolled in the study. Follow-up clinic appointments were scheduled for 2-4 weeks post-discharge. During admission and follow-up, blood samples were collected from each patient for laboratory analysis. Anti-nucleoprotein SARS-CoV-2 IgG levels were determined using the Enzyme-Linked Immunosorbent Assay (ELISA) method. Results: In this study, a cohort of 58 patients was examined. At admission, 52% (n = 14) of MIS-C patients and 10% (n = 3) of acute COVID-19 patients had positive SARS-CoV-2 IgG test. Only 48 cases were referred to the hospital, and follow-up data was available for 20 cases with MIS-C and 28 cases with acute COVID-19. All patients (n = 15) who initially tested positive for SARS-CoV-2 IgG at admission remained positive serology during follow-up (100%). Among the 33 patients who initially tested negative, 12 (37.5%) showed a positive serology result during follow-up, while 21 (62.5%) remained negative. Within this subgroup, 11 cases (44%) were diagnosed with acute COVID-19, and one patient (12.5%) presented with MIS-C. Fourteen cases with acute COVID-19 infection (56%) and seven cases with MIS-C (87.5%) consistently showed negative serology results throughout the study. During follow-up, the median lymphocyte count demonstrated a significant difference, with 0.96 x 109 cells per L (IQR: 0.75-3.0 x 109 cells per L) in the SARS-CoV-2 IgG-negative group and 2.9 x 109 cells per L (IQR = 1.33-7.22 x 109 cells per L) in the SARS-CoV-2 IgG-positive group (p-value = 0.03). Patients who demonstrated seropositivity during the follow-up were associated with a notably severe disease (p-value = 0.028). Conclusion: Our study highlights the dynamic nature of SARS-CoV-2 IgG antibody responses in pediatric patients with COVID-19 infection. We observed a notable increase in seropositivity rates during follow-up. Furthermore, patients who were seropositive at follow-up demonstrated a severe disease course and lower lymphocyte counts compared to those with persistently negative serology. Our findings underscore the importance of longitudinal serological monitoring in understanding disease progression and immune response dynamics in pediatric COVID-19 cases. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Comparison of Common Monogenic Defects in a Large Predominantly Antibody Deficiency Cohort

Author

Yazdani, Reza, Abolhassani, Hassan, Kiaee, Fatemeh, Habibi, Sima, Azizi, Gholamreza, Tavakol, Marzieh, Chavoshzadeh, Zahra, Mahdaviani, Seyed Alireza, Momen, Tooba, Gharagozlou, Mohammad, Movahedi, Masoud, Hamidieh, Amir Ali, Behniafard, Nasrin, Nabavi, Mohammamd, Bemanian, Mohammad Hassan, Arshi, Saba, Molatefi, Rasol, Sherkat, Roya, Shirkani, Afshin, Amin, Reza, Aleyasin, Soheila, Faridhosseini, Reza, Jabbari-Azad, Farahzad, Mohammadzadeh, Iraj, Ghaffari, Javad, Shafiei, Alireza, Kalantari, Arash, Mansouri, Mahboubeh, Mesdaghi, Mehrnaz, Babaie, Delara, Ahanchian, Hamid, Khoshkhui, Maryam, Soheili, Habib, Eslamian, Mohammad Hossein, Cheraghi, Taher, Dabbaghzadeh, Abbas, Tavassoli, Mahmoud, Kalmarzi, Rasoul Nasiri, Mortazavi, Seyed Hamidreza, Kashef, Sara, Esmaeilzadeh, Hossein, Tafaroji, Javad, Khalili, Abbas, Zandieh, Fariborz, Sadeghi-Shabestari, Mahnaz, Darougar, Sepideh, Behmanesh, Fatemeh, Akbari, Hedayat, Zandkarimi, Mohammadreza, Abolnezhadian, Farhad, Fayezi, Abbas, Moghtaderi, Mojgan, Ahmadiafshar, Akefeh, Shakerian, Behzad, Sajedi, Vahid, Taghvaei, Behrang, Safari, Mojgan, Heidarzadeh, Marzieh, Ghalebaghi, Babak, Fathi, Seyed Mohammad, Darabi, Behzad, Bazregari, Saeed, Bazargan, Nasrin, Fallahpour, Morteza, Khayatzadeh, Alireza, Javahertrash, Naser, Bashardoust, Bahram, Zamani, Mohammadali, Mohsenzadeh, Azam, Ebrahimi, Sarehsadat, Sharafian, Samin, Vosughimotlagh, Ahmad, Tafakoridelbari, Mitra, Rahim, Maziar, Ashournia, Parisa, Razaghian, Anahita, Rezaei, Arezou, Samavat, Ashraf, Mamishi, Setareh, Khazaei, Hossein Ali, Mohammadi, Javad, Negahdari, Babak, Parvaneh, Nima, Rezaei, Nima, Lougaris, Vassilios, Giliani, Silvia, Plebani, Alessandro, Ochs, Hans D., Hammarström, Lennart, and Aghamohammadi, Asghar

Published
2019
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39. High prevalence of carbapenem resistance and clonal expansion of blaNDM gene in Klebsiella pneumoniae isolates in an Iranian referral pediatric hospital.

Author

Pourakbari, Babak, Mamishi, Setareh, Poormohammadi, Shiva, Hosseinpour Sadeghi, Reihaneh, and Mahmoudi, Shima

Subjects
*KLEBSIELLA pneumoniae, *CHILDREN'S hospitals, *CARBAPENEM-resistant bacteria, *PULSED-field gel electrophoresis, *MICROBIAL sensitivity tests, *HERBICIDE resistance
Abstract

Background: The increasing global concern regarding antibiotic resistance necessitates in-depth studies to comprehend the phenotypic and genotypic characteristics of resistant bacterial strains. This study aimed to investigate the prevalence, antibiotic resistance profiles, and molecular characteristics of carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates in an Iranian referral pediatrics hospital. Methods: In this study, we examined CRKP isolates collected from hospitalized pediatric patients across various wards. The isolates underwent antimicrobial susceptibility testing, the polymerase chain reaction (PCR) analysis for carbapenemase genes (blaNDM, blaVIM and blaIMP), and genetic relatedness assessment using pulsed-field gel electrophoresis (PFGE). Results: Among 166 K. pneumoniae isolates, 54 (32.5%) exhibited resistance to carbapenems. Notably, all these resistant isolates were resistant to imipenem, with 35 (65%) displaying resistance to both imipenem and meropenem. Of the 54 CRKP isolates, 24 (44%) were metallo-β-lactamases (MBL)-producing. The prevalence of the blaNDM gene among CKCP and MBL-producing isolates was 20% (n = 11) and 44% (n = 24), respectively. The blaVIM and blaIMP genes were not detected in any of the isolates. Twenty-six CRKP isolates (48%) were recovered from ICUs. PFGE analysis of CRKP isolates revealed 20 clusters, with cluster S being the most prevalent, comprising 24% of the total (n = 13). Conclusion: Our study reveals a concerning prevalence of carbapenem resistance in K. pneumoniae isolates. Specifically, the detection of the blaNDM gene in 20% of CRKP isolates, with a significant proportion (82%) observed in isolated CRKP from the ICUs and emergency departments, underscores the potential clonal expansion of these resistant strains within these critical hospital wards. [ABSTRACT FROM AUTHOR]

Published
2024
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40. Fourth Update on the Iranian National Registry of Primary Immunodeficiencies: Integration of Molecular Diagnosis

Author

Abolhassani, Hassan, Kiaee, Fatemeh, Tavakol, Marzieh, Chavoshzadeh, Zahra, Mahdaviani, Seyed Alireza, Momen, Tooba, Yazdani, Reza, Azizi, Gholamreza, Habibi, Sima, Gharagozlou, Mohammad, Movahedi, Masoud, Hamidieh, Amir Ali, Behniafard, Nasrin, Nabavi, Mohammamd, Bemanian, Mohammad Hassan, Arshi, Saba, Molatefi, Rasol, Sherkat, Roya, Shirkani, Afshin, Amin, Reza, Aleyasin, Soheila, Faridhosseini, Reza, Jabbari-Azad, Farahzad, Mohammadzadeh, Iraj, Ghaffari, Javad, Shafiei, Alireza, Kalantari, Arash, Mansouri, Mahboubeh, Mesdaghi, Mehrnaz, Babaie, Delara, Ahanchian, Hamid, Khoshkhui, Maryam, Soheili, Habib, Eslamian, Mohammad Hossein, Cheraghi, Taher, Dabbaghzadeh, Abbas, Tavassoli, Mahmoud, Kalmarzi, Rasoul Nasiri, Mortazavi, Seyed Hamidreza, Kashef, Sara, Esmaeilzadeh, Hossein, Tafaroji, Javad, Khalili, Abbas, Zandieh, Fariborz, Sadeghi-Shabestari, Mahnaz, Darougar, Sepideh, Behmanesh, Fatemeh, Akbari, Hedayat, Zandkarimi, Mohammadreza, Abolnezhadian, Farhad, Fayezi, Abbas, Moghtaderi, Mojgan, Ahmadiafshar, Akefeh, Shakerian, Behzad, Sajedi, Vahid, Taghvaei, Behrang, Safari, Mojgan, Heidarzadeh, Marzieh, Ghalebaghi, Babak, Fathi, Seyed Mohammad, Darabi, Behzad, Bazregari, Saeed, Bazargan, Nasrin, Fallahpour, Morteza, Khayatzadeh, Alireza, Javahertrash, Naser, Bashardoust, Bahram, Zamani, Mohammadali, Mohsenzadeh, Azam, Ebrahimi, Sarehsadat, Sharafian, Samin, Vosughimotlagh, Ahmad, Tafakoridelbari, Mitra, Rahimi, Maziar, Ashournia, Parisa, Razaghian, Anahita, Rezaei, Arezou, Mamishi, Setareh, Parvaneh, Nima, Rezaei, Nima, Hammarström, Lennart, and Aghamohammadi, Asghar

Published
2018
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44. Neurologic Manifestations of Coronavirus Disease 2019 in Children: An Iranian Hospital-Based Study

Author

Haji Esmaeil Memar, Elmira, primary, Heidari, Morteza, additional, Ghabeli, Homa, additional, Pourbakhtyaran, Elham, additional, Haghighi, Roya, additional, Hosseiny, Seyyed Mohammad Mahdi, additional, Mamishi, Setareh, additional, Mahmoudi, Shima, additional, Eshaghi, Hamid, additional, Tavasoli, Ali Reza, additional, Mohammadi, Mahmoud, additional, Shervin Badv, Reza, additional, Zamani, Gholamreza, additional, Ghahvehchi Akbari, Masood, additional, Yarali, Bahram, additional, Shirzadi, Rohola, additional, Mohammadpour, Masoud, additional, Yaghmaei, Bahareh, additional, Sharifzadeh Ekbatani, Meisam, additional, Najafi, Zeynab, additional, and Ashrafi, Mahmoud Reza, additional

Published
2023
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49. Childhood Guillain–Barre syndrome in the SARS‐CoV ‐2 era: Is there any causative relation?

Author

Pourbakhtyaran, Elham, primary, Heidari, Morteza, additional, Akbari, Masood Ghahvechi, additional, Mohammadi, Mahmoud, additional, Badv, Reza Shervin, additional, Zamani, Gholamreza, additional, Tavasoli, Ali Reza, additional, Rezaei, Zahra, additional, Mamishi, Setareh, additional, Haji Esmaeil Memar, Elmira, additional, Hosseiny, Seyyed Mohammad Mahdi, additional, Ghabeli, Homa, additional, Haghighi, Roya, additional, and Ashrafi, Mahmoud Reza, additional

Published
2022
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50. COVID-19 Pandemic Experiences in Pediatric Intensive Care Unit: An Iranian Referral Hospital-Based Study

Author

Mohammadpour, Masoud, primary, Hassani, Seyed Abbas, additional, Sharifzadeh, Meisam, additional, Tahernia, Leila, additional, Mamishi, Setareh, additional, Yaghmaie, Bahareh, additional, Najafi, Zeinab, additional, Beirami, Farzaneh, additional, Afsharipour, Mehrnoush, additional, Minuyeefar, Maryam, additional, Dolatzadeh, Mina, additional, Pak, Neda, additional, Majmaa, Anahita, additional, Zamani, Zahra, additional, and Mahmoudi, Shima, additional

Published
2022
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