Search

Your search keyword '"Mameli, Maria Grazia"' showing total 12 results
Start Over Author "Mameli, Maria Grazia"
12 results on '"Mameli, Maria Grazia"'

1. Immune correlates of protection by vaccine against SARS‐CoV ‐2 in patients with chronic lymphocytic leukaemia

Author

Sorcini, Daniele, primary, De Falco, Filomena, additional, Gargaro, Marco, additional, Bozza, Silvia, additional, Guarente, Valerio, additional, Cardinali, Valeria, additional, Stella, Arianna, additional, Adamo, Francesco Maria, additional, Silva Barcelos, Estevao Carlos, additional, Rompietti, Chiara, additional, Dorillo, Erica, additional, Geraci, Clelia, additional, Esposito, Angela, additional, Arcaleni, Roberta, additional, Capoccia, Silvia, additional, Mameli, Maria Grazia, additional, Graziani, Alessandro, additional, Moretti, Lorenzo, additional, Cipiciani, Alessandra, additional, Riccardi, Carlo, additional, Mencacci, Antonella, additional, Fallarino, Francesca, additional, Rosati, Emanuela, additional, and Sportoletti, Paolo, additional

Published
2022
Full Text
View/download PDF

3. Phosphoinositide-3-Kinase Catalytic Alpha and KRAS Mutations are Important Predictors of Resistance to Therapy with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Patients with Advanced Non-small Cell Lung Cancer

Author

Ludovini, Vienna, Bianconi, Fortunato, Pistola, Lorenza, Chiari, Rita, Minotti, Vincenzo, Colella, Renato, Giuffrida, Dario, Tofanetti, Francesca Romana, Siggillino, Annamaria, Flacco, Antonella, Baldelli, Elisa, Iacono, Daniela, Mameli, Maria Grazia, Cavaliere, Antonio, and Crinò, Lucio

Published
2011
Full Text
View/download PDF

4. Immune correlates of protection by vaccine against SARS‐CoV‐2 in patients with chronic lymphocytic leukaemia.

Author

Sorcini, Daniele, De Falco, Filomena, Gargaro, Marco, Bozza, Silvia, Guarente, Valerio, Cardinali, Valeria, Stella, Arianna, Adamo, Francesco Maria, Silva Barcelos, Estevao Carlos, Rompietti, Chiara, Dorillo, Erica, Geraci, Clelia, Esposito, Angela, Arcaleni, Roberta, Capoccia, Silvia, Mameli, Maria Grazia, Graziani, Alessandro, Moretti, Lorenzo, Cipiciani, Alessandra, and Riccardi, Carlo

Subjects
LYMPHOCYTIC leukemia, CHRONIC leukemia, COVID-19 vaccines, BRUTON tyrosine kinase, INTERFERON gamma
Abstract

Summary: In chronic lymphocytic leukaemia (CLL) the efficacy of SARS‐CoV‐2 vaccination remains unclear as most studies have focused on humoral responses. Here we comprehensively examined humoral and cellular responses to vaccine in CLL patients. Seroconversion was observed in 55.2% of CLL with lower rate and antibody titres in treated patients. T‐cell responses were detected in a significant fraction of patients. CD4+ and CD8+ frequencies were significantly increased independent of serology with higher levels of CD4+ cells in patients under a Bruton tyrosine kinase (BTK) or a B‐cell lymphoma 2 (BCL‐2) inhibitor. Vaccination skewed CD8+ cells towards a highly cytotoxic phenotype, more pronounced in seroconverted patients. A high proportion of patients showed spike‐specific CD4+ and CD8+ cells producing interferon gamma (IFNγ) and tumour necrosis factor alpha (TNFα). Patients under a BTK inhibitor showed increased production of IFNγ and TNFα by CD4+ cells. Vaccination induced a Th1 polarization reverting the Th2 CLL T‐cell profile in the majority of patients with lower IL‐4 production in untreated and BTK‐inhibitor‐treated patients. Such robust T‐cell responses may have contributed to remarkable protection against hospitalization and death in a cohort of 540 patients. Combining T‐cell metrics with seroprevalence may yield a more accurate measure of population immunity in CLL, providing consequential insights for public health. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

5. Indoleamine 2,3-Dioxygenase 1 (IDO1) Is Up-Regulated in Thyroid Carcinoma and Drives the Development of an Immunosuppressant Tumor Microenvironment

Author

Moretti, Sonia, Menicali, Elisa, Voce, Pasquale, Morelli, Silvia, Cantarelli, Sara, Sponziello, Marialuisa, Colella, Renato, Fallarino, Francesca, Orabona, Ciriana, Alunno, Alessia, de Biase, Dario, Bini, Vittorio, Mameli, Maria Grazia, Filetti, Sebastiano, Gerli, Roberto, Macchiarulo, Antonio, Melillo, Rosa Marina, Tallini, Giovanni, Santoro, Massimo, Puccetti, Paolo, Avenia, Nicola, and Puxeddu, Efisio

Published
2014

6. A Curious Novel Combination of Nucleophosmin (NPM1) Gene Mutations Leading to Aberrant Cytoplasmic Dislocation of NPM1 in Acute Myeloid Leukemia (AML)

Author

Venanzi, Alessandra, primary, Rossi, Roberta, additional, Martino, Giovanni, additional, Annibali, Ombretta, additional, Avvisati, Giuseppe, additional, Mameli, Maria Grazia, additional, Sportoletti, Paolo, additional, Tiacci, Enrico, additional, Falini, Brunangelo, additional, and Martelli, Maria Paola, additional

Published
2021
Full Text
View/download PDF

7. NOTCH1 Activation Negatively Impacts on Chronic Lymphocytic Leukemia Outcome and Is Not Correlated to the NOTCH1 and IGHV Mutational Status

Author

Baldoni, Stefano, primary, Del Papa, Beatrice, additional, De Falco, Filomena, additional, Dorillo, Erica, additional, Sorrentino, Carlo, additional, Rompietti, Chiara, additional, Adamo, Francesco Maria, additional, Nogarotto, Manuel, additional, Cecchini, Debora, additional, Mondani, Elena, additional, Silva Barcelos, Estevao Carlos, additional, Moretti, Lorenzo, additional, Mameli, Maria Grazia, additional, Fabi, Bianca, additional, Sorcini, Daniele, additional, Stella, Arianna, additional, Giancola, Raffaella, additional, Guardalupi, Francesco, additional, Ulbar, Francesca, additional, Plebani, Sara, additional, Guarente, Valerio, additional, Rosati, Emanuela, additional, Di Nicola, Marta, additional, Marchioni, Michele, additional, Di Ianni, Mauro, additional, and Sportoletti, Paolo, additional

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results