25 results on '"Maman, Laminou Ibrahim"'
Search Results
2. Plasmodium falciparum kelch13 polymorphisms identified after treatment failure with artemisinin-based combination therapy in Niger
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Arzika, Ibrahima Issa, Lobo, Neil F., Lamine, Mahaman Moustapha, Tidjani, Ilagouma Amadou, Sandrine, Houzé, Sarrasin-Hubert, Véronique, Mahamadou, Aboubacar, Adehossi, Eric, Sarr, Demba, Mahmud, Ousman, and Maman Laminou, Ibrahim
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- 2023
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3. Evidence that seasonal malaria chemoprevention with SPAQ influences blood and pre-erythrocytic stage antibody responses of Plasmodium falciparum infections in Niger
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Lamine Mahaman Moustapha, Rafiou Adamou, Maman Laminou Ibrahim, Mariama Abdoulaye Louis Padounou, Abdoulaye Diallo, David Courtin, Jean Testa, and Jean Louis Abdourahim Ndiaye
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Seasonal malaria chemoprevention ,Immunity ,Antibody ,CSP ,GLURP-R2 ,P. falciparum ,Arctic medicine. Tropical medicine ,RC955-962 ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background In endemic areas, children develop slowly and naturally anti-Plasmodium antibodies and become semi-immune. Seasonal Malaria Chemoprevention (SMC) with sulfadoxine-pyrimethamine + amodiaquine (SPAQ) is a new strategy to reduce malaria morbidity in West African young children. However, SMC may impact on the natural acquisition of anti-Plasmodium immunity. This paper evaluates the effect of SMC with SPAQ on antibody concentration in young children from Niger. Methods This research was conducted in areas benefitting from SMC since 2014 (Zinder district), without SMC (Dosso district), and with 1 year of SMC since 2016 (Gaya district). To assess the relationship between SMC and Plasmodium falciparum IgG antibody responses, the total antibody concentrations against two P. falciparum asexual stage vaccine candidate antigens, circumsporozoite protein (CSP) and glutamate-rich protein R2 (GLURP-R2), in children aged 3 to 59 months across the three areas were compared. Antibody concentrations are quantified using an enzyme-linked immunosorbent assay on the elution extracted from positive and negative malaria Rapid Diagnostic Test cassettes. Results The analysis concerns two hundred and twenty-nine children aged from 3 to 59 months: 71 in Zinder, 77 in Dosso, and 81 in Gaya. In Zinder (CSP = 17.5 µg/ml and GLURP-R2 = 14.3 µg/ml) median antibody concentration observed are higher than in Gaya (CSP = 7.7 µg/ml and GLURP-R2 = 6.5 µg/ml) and Dosso (CSP = 4.5 µg/ml and GLURP-R2 = 3.6 µg/ml) (p
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- 2021
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4. Teaching One Health: Animal husbandry in a post-graduate interdisciplinary curriculum
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Djibo Idrissa Sidikou, Yannick Caron, Catherine Delguste, Abdoulkarim Issa Ibrahim, Maman Laminou Ibrahim, Hassane Adakal, Jean-Luc Hornick, and Nicolas Antoine-Moussiaux
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animal husbandry ,curriculum ,interdisciplinarity ,one health ,Medicine ,Medicine (General) ,R5-920 - Abstract
Background and Aim: This work presents the implementation of a course on animal husbandry in an interdisciplinary curriculum based on the One Health concept. The study describes learners' viewpoints about the course and its insertion in the curriculum. The study aimed at identifying avenues for improvement. Materials and Methods: Fourteen learners (health professionals) participated to individual semi-structured interviews lasting for 25-35 min each. Learners' opinions were extracted from the transcribed interviews and analysis themes were identified from recurrent narratives. Results: The learners perceived animal husbandry as relevant for One Health and potentially useful for their future practice. More precisely, learners were considering a future use of the newly acquired knowledge and skills in the advising of communities facing malnutrition and for the strategic planning at wider levels. Teaching methods were appreciated thanks to the active learning style. Unmet expectations concerned the coverage of impacts and relationships to other disciplines, the inclusion of viewpoints from other disciplines into the teaching, and the degree of contextualization of contents, e.g. through case studies. Accordingly, the main avenues for improvement, as identified by learners, were to give a prior focus on impacts (especially on human health) for all contents and to increase the number of case studies, but also to better address the questions of the usefulness of animal products in the management of malnutrition. Conclusion: The analysis of learners' expectations (met and unmet) and their recommendations regarding the future of the course helped identifying both successes and important challenges for teachers. Two main challenges are highlighted. First, increased interdisciplinarity is needed within the course to better cover the notion of impact of animal husbandry on health, society and environment. Second, the complexity of the domain under consideration will call for important efforts of clarification of the course structure and objectives in terms of skills acquisition.
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- 2020
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5. A Fatal Case of COVID-19 in an Infant with Severe Acute Malnutrition Admitted to a Paediatric Ward in Niger
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Alido Soumana, Aboubacar Samaila, Lamine Mahaman Moustapha, Moumouni Kamaye, Balkissa Daouda, Ibrahim Alkassoum Salifou, Adamou Lagare, Eric Omar Adehossi, and Maman Laminou Ibrahim
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Pediatrics ,RJ1-570 - Abstract
While there have been very few fatal cases, SARS-CoV-2 has been reported in paediatric patients. This study aims to describe a fatal case of COVID-19 in a child with severe acute malnutrition. The eight-month-old child presented with fever, diarrhoea, and difficulty in breathing. The mother of the child had fever and shortness of breath four weeks before she died. Physical examination revealed lethargy, dehydration, and severe weight loss with a weight of 5 kg at a height of 78 cm tall. The weight-for-height index was less than three Z-scores, which corresponds to severe acute malnutrition. The pulmonary examination revealed moderate respiratory distress, and the chest X-ray presented features suggestive of pneumonia in the right lung area. In the context of the COVID-19 outbreak in Niger and the circumstances of the mother’s death, a nasal swab was taken for laboratory confirmation. Treatment provided to the child included intranasal oxygen, antibiotics, and a dietary program with therapeutic milk. The child died 48 hours after his admission. The history of contact with a SARS-CoV-2 suspect or positive patient should lead to screening for infection by using RT-PCR. It is important to investigate malnutrition as a potential risk factor for severe SARS-CoV-2 infection and resultant mortality.
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- 2020
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- View/download PDF
6. Teaching One Health: Animal husbandry in a post-graduate interdisciplinary curriculum
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Nicolas Antoine-Moussiaux, Hassane Adakal, D. I. Sidikou, Catherine Delguste, Abdoulkarim Issa Ibrahim, Maman Laminou Ibrahim, Yannick Caron, and Jean-Luc Hornick
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Medical education ,animal husbandry ,lcsh:R5-920 ,General Veterinary ,040301 veterinary sciences ,Health Policy ,030231 tropical medicine ,lcsh:R ,Public Health, Environmental and Occupational Health ,curriculum ,lcsh:Medicine ,04 agricultural and veterinary sciences ,Animal husbandry ,0403 veterinary science ,03 medical and health sciences ,Interdisciplinary curriculum ,one health ,0302 clinical medicine ,Infectious Diseases ,One Health ,interdisciplinarity ,ComputingMilieux_COMPUTERSANDEDUCATION ,Post graduate ,Sociology ,lcsh:Medicine (General) - Abstract
Background and Aim: This work presents the implementation of a course on animal husbandry in an interdisciplinary curriculum based on the One Health concept. The study describes learners' viewpoints about the course and its insertion in the curriculum. The study aimed at identifying avenues for improvement. Materials and Methods: Fourteen learners (health professionals) participated to individual semi-structured interviews lasting for 25-35 min each. Learners' opinions were extracted from the transcribed interviews and analysis themes were identified from recurrent narratives. Results: The learners perceived animal husbandry as relevant for One Health and potentially useful for their future practice. More precisely, learners were considering a future use of the newly acquired knowledge and skills in the advising of communities facing malnutrition and for the strategic planning at wider levels. Teaching methods were appreciated thanks to the active learning style. Unmet expectations concerned the coverage of impacts and relationships to other disciplines, the inclusion of viewpoints from other disciplines into the teaching, and the degree of contextualization of contents, e.g. through case studies. Accordingly, the main avenues for improvement, as identified by learners, were to give a prior focus on impacts (especially on human health) for all contents and to increase the number of case studies, but also to better address the questions of the usefulness of animal products in the management of malnutrition. Conclusion: The analysis of learners' expectations (met and unmet) and their recommendations regarding the future of the course helped identifying both successes and important challenges for teachers. Two main challenges are highlighted. First, increased interdisciplinarity is needed within the course to better cover the notion of impact of animal husbandry on health, society and environment. Second, the complexity of the domain under consideration will call for important efforts of clarification of the course structure and objectives in terms of skills acquisition.
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- 2020
7. Evidence that seasonal malaria chemoprevention with SPAQ influences blood and pre-erythrocytic stage antibody responses of Plasmodium falciparum infections in Niger
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Maman Laminou Ibrahim, Jean Louis Ndiaye, Jean Testa, Rafiou Adamou, A. Diallo, David Courtin, Mariama Abdoulaye Louis Padounou, and Lamine Mahaman Moustapha
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lcsh:Arctic medicine. Tropical medicine ,lcsh:RC955-962 ,Plasmodium falciparum ,Antibodies, Protozoan ,P. falciparum ,Biology ,Chemoprevention ,lcsh:Infectious and parasitic diseases ,Antimalarials ,CSP ,Antigen ,Immunity ,Sulfadoxine ,parasitic diseases ,medicine ,Humans ,lcsh:RC109-216 ,Niger ,Malaria, Falciparum ,Antibody ,Rapid diagnostic test ,Research ,Amodiaquine ,Infant ,medicine.disease ,biology.organism_classification ,Circumsporozoite protein ,Drug Combinations ,Pyrimethamine ,Infectious Diseases ,Parasitology ,Child, Preschool ,Antibody Formation ,Immunology ,Seasonal malaria chemoprevention ,biology.protein ,Seasons ,GLURP-R2 ,Malaria - Abstract
Background In endemic areas, children develop slowly and naturally anti-Plasmodium antibodies and become semi-immune. Seasonal Malaria Chemoprevention (SMC) with sulfadoxine-pyrimethamine + amodiaquine (SPAQ) is a new strategy to reduce malaria morbidity in West African young children. However, SMC may impact on the natural acquisition of anti-Plasmodium immunity. This paper evaluates the effect of SMC with SPAQ on antibody concentration in young children from Niger. Methods This research was conducted in areas benefitting from SMC since 2014 (Zinder district), without SMC (Dosso district), and with 1 year of SMC since 2016 (Gaya district). To assess the relationship between SMC and Plasmodium falciparum IgG antibody responses, the total antibody concentrations against two P. falciparum asexual stage vaccine candidate antigens, circumsporozoite protein (CSP) and glutamate-rich protein R2 (GLURP-R2), in children aged 3 to 59 months across the three areas were compared. Antibody concentrations are quantified using an enzyme-linked immunosorbent assay on the elution extracted from positive and negative malaria Rapid Diagnostic Test cassettes. Results The analysis concerns two hundred and twenty-nine children aged from 3 to 59 months: 71 in Zinder, 77 in Dosso, and 81 in Gaya. In Zinder (CSP = 17.5 µg/ml and GLURP-R2 = 14.3 µg/ml) median antibody concentration observed are higher than in Gaya (CSP = 7.7 µg/ml and GLURP-R2 = 6.5 µg/ml) and Dosso (CSP = 4.5 µg/ml and GLURP-R2 = 3.6 µg/ml) (p Conclusion The research reveals some evidences which show that seasonal malaria chemoprevention with SPAQ has an effect on blood stage antibody responses and pre-erythrocytic stage of P. falciparum infections in Niger. Increased antibody titres with increased SMC/SPAQ implementation. This contradicts hypothesis that SMC/SPAQ could reduce immunity to erythrocyte and liver-stage antigens. Further studies are necessary to provide better understanding of the SMC effect on malaria immunity.
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- 2021
8. Some evidence that seasonal malaria chemoprevention with SPAQ has an effect on blood stage antibody responses and pre-erythrocytic stage of Plasmodium falciparum infections in Niger
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Lamine Mahaman Moustapha, Rafiou Adamou, Maman Laminou Ibrahim, Mariama Abdoulaye Louis Padounou, Abdoulaye Diallo, David Courtin, Jean Testa, and Jean Louis NDiaye
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parasitic diseases - Abstract
Background: In endemic areas, children develop slowly and naturally develop anti-Plasmodium antibodies and become semi-immune. Seasonal Malaria Chemoprevention (SMC) with sulfadoxine-pyrimethamine + amodiaquine (SPAQ) is a new strategy to reduce malaria morbidity in young children in West Africa. However, SMC may impact on the natural acquisition of anti-Plasmodium immunity. We evaluated the effect of SMC with SPAQ on malaria antibody concentration in Niger.Methods: This survey was conducted in areas targeted with SMC since 2014 (Zinder district), without SMC (Dosso district), and with one year SMC 2016 (Gaya district). To assess the relationship between SMC and P. falciparum IgG antibody responses, we compared total antibody concentrations against two P. falciparum asexual stage vaccine candidate antigens, circumsporozoite protein (CSP) and glutamate-rich protein R2 (GLURP-R2), in children aged 3-59 months across the three sites. Antibody concentrations were quantified using an enzyme-linked immunosorbent assay (ELISA) on the elution extracted from positive and negative RDT cassettes.Results: A total of 229 children aged 3-59 months were included in the analysis: 71 in Zinder, 77 in Dosso, and 81 in Gaya. In Zinder (CSP=17.5µg/ml and GLURP-R2=14.3µg/ml) median antibody concentration observed were higher than in Gaya (CSP=7.7 µg/ml and GLURP-R2=6.5 µg/ml) and Dosso (CSP=4.5 µg/ml and GLURP-R2=3.6 µg/ml) (pConclusion: We have some evidence that seasonal malaria chemoprevention with SPAQ has an effect on blood stage antibody responses and pre-erythrocytic stage of Plasmodium falciparum infections in Niger. Future studies are necessary to provide better understanding of the effect of on malaria immunity.
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- 2020
9. A Fatal Case of COVID-19 in an Infant with Severe Acute Malnutrition Admitted to a Paediatric Ward in Niger
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Adamou Lagare, Balkissa Daouda, Maman Laminou Ibrahim, M. Kamaye, Aboubacar Samaila, Lamine Mahaman Moustapha, A. Soumana, Eric Adehossi, and Ibrahim Alkassoum Salifou
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Pediatrics ,medicine.medical_specialty ,Lung ,Respiratory distress ,medicine.diagnostic_test ,business.industry ,Severe Acute Malnutrition ,Context (language use) ,Physical examination ,General Medicine ,medicine.disease ,RJ1-570 ,03 medical and health sciences ,Pneumonia ,Malnutrition ,Lethargy ,0302 clinical medicine ,medicine.anatomical_structure ,030225 pediatrics ,medicine ,030212 general & internal medicine ,business - Abstract
While there have been very few fatal cases, SARS-CoV-2 has been reported in paediatric patients. This study aims to describe a fatal case of COVID-19 in a child with severe acute malnutrition. The eight-month-old child presented with fever, diarrhoea, and difficulty in breathing. The mother of the child had fever and shortness of breath four weeks before she died. Physical examination revealed lethargy, dehydration, and severe weight loss with a weight of 5 kg at a height of 78 cm tall. The weight-for-height index was less than three Z-scores, which corresponds to severe acute malnutrition. The pulmonary examination revealed moderate respiratory distress, and the chest X-ray presented features suggestive of pneumonia in the right lung area. In the context of the COVID-19 outbreak in Niger and the circumstances of the mother’s death, a nasal swab was taken for laboratory confirmation. Treatment provided to the child included intranasal oxygen, antibiotics, and a dietary program with therapeutic milk. The child died 48 hours after his admission. The history of contact with a SARS-CoV-2 suspect or positive patient should lead to screening for infection by using RT-PCR. It is important to investigate malnutrition as a potential risk factor for severe SARS-CoV-2 infection and resultant mortality.
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- 2020
10. Some evidence that seasonal malaria chemoprevention with SPAQ did not have effect on antibodies response against pre-erythrocyte stage but on the blood-stage in Niger
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Lamine Mahaman Moustapha, Rafiou Adamou, Maman Laminou Ibrahim, Mariama Abdoulaye Louis Padounou, Abdoulaye Diallo, David Courtin, Jean Testa, and Jean Louis NDiaye
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parasitic diseases - Abstract
Background: In endemic areas, children develop slowly and naturally anti-Plasmodium antibodies and become semi-immune. Seasonal Malaria Chemoprevention (SMC) with sulfadoxine-pyrimethamine + amodiaquine (SPAQ) is a new strategy to reduce malaria morbidity in young children in West Africa. However, SMC may impact on the natural acquisition of anti-Plasmodium immunity. We evaluated the effect of SMC with SPAQ on malaria antibodies levels in Niger. Methods: This survey was conducted in areas with SMC since 2014 (Zinder district), without SMC (Dosso district) and with one year SMC 2016 (Gaya district). To assess the relationship between SMC and total Ig G Ab against P. falciparum antigens, we measured antibodies levels of two P.falciparum asexual stage vaccine candidate antigens (Circum Sporozoid Protein and Glutamate-rich Protein R2) in children aged 3–59 months and compared these levels in Zinder, Dosso and Gaya by enzyme-linked immune-sorbent assay (ELISA) on the elution extracted from the RDTs positive and negative cassette. Results: A total of 229 children aged 3-59 months were included in the analysis: 71 in Zinder, 77 in Dosso, and 81 in Gaya. In Zinder (CSP=17.5 and GLURP-R2=14.3) median antibodies levels observed were higher than in Gaya (CSP=7.7 and GLURP-R2=6.5) and Dosso (CSP=4.5 and GLURP-R2=3.6) (p
- Published
- 2019
11. Controlling schistosomiasis: significant decrease of anaemia prevalence one year after a single dose of praziquantel in Nigerian schoolchildren.
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Zilahatou B Tohon, Halima B Mainassara, Amadou Garba, Ali E Mahamane, Elisa Bosqué-Oliva, Maman-Laminou Ibrahim, Jean-Bernard Duchemin, Suzanne Chanteau, and Pascal Boisier
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Arctic medicine. Tropical medicine ,RC955-962 ,Public aspects of medicine ,RA1-1270 - Abstract
BACKGROUND: In the framework of the monitoring and evaluation of the Nigerian schistosomiasis and soil-transmitted helminth control programme, a follow-up of children took place in eight sentinel sites. The objective of the study was to assess the evolution of Schistosoma haematobium infection and anaemia in schoolchildren after a single administration of praziquantel (PZQ) and albendazole. METHODS/PRINCIPAL FINDINGS: Pre-treatment examination and follow-up at one year post-treatment of schoolchildren aged 7, 8, and 11 years, including interview, urine examination, ultrasound examination of the urinary tract, and measurement of haemoglobin. Before treatment, the overall prevalence of S. heamatobium infection was 75.4% of the 1,642 enrolled children, and 21.8% of children excreted more than 50 eggs/10 ml urine. Prevalence increased with age. The overall prevalence of anaemia (haemoglobin
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- 2008
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12. Competing risk events in antimalarial drug trials in uncomplicated Plasmodium falciparum malaria: a WorldWide Antimalarial Resistance Network individual participant data meta-analysis
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Pedro Rafael Dimbu, Marit De Wit, Kamala L. Thriemer, Sarah G. Staedke, Filomeno Fortes, Salim Abdulla, Julie A. Simpson, Oliver James Pratt, Bart Janssens, Andreas Mårtensson, Veronique Sinou, Steffen Borrmann, Walter R. J. Taylor, Ingrid van der Broek, Christopher J. M. Whitty, Meghna Desai, François Bompart, Zulfikarali Premji, Theonest K. Mutabingwa, Aarti Agarwal, Anupkumar R. Anvikar, Emmanuel Arinaitwe, Petra F. Mens, Piero Olliaro, François Nosten, Maman Laminou Ibrahim, Birgit Schramm, Hasifa Bukirwa, Michèle van Vugt, Jane Achan, J. Pedro Gil, Timothy M. E. Davis, Ogobara K. Doumbo, Michel Cot, Grant Dorsey, Michael Ramharter, Sue J. Lee, Sodiomon B. Sirima, Ambrose O. Talisuna, Poul-Erik Kofoed, Brian Greenwood, Catherine O. Falade, Valerie Lameyre, Mayfong Mayxay, Andre Toure Offianan, Hervé Ei Menan, Teun Bousema, Erasmus Kamugisha, Chris J. Drakeley, Elizabeth Juma, Johan Ursing, Abul Faiz, Emmanuel Temu, Carol Hopkins Sibley, Patrice Piola, Philip J. Rosenthal, Frank Smithuis, Mateusz M. Plucinski, Marco Corsi, Anastasia Grivoyannis, Richard Allan, Elizabeth A. Ashley, Harald Noedl, Jean François Faucher, Issaka Zongo, Corine Karema, Cornelis Winnips, Kamal Hamed, Umberto D'Alessandro, Venkatachalam Udhayakumar, Michael D. Edstein, Fred Kironde, Harin Karunajeewa, Philippe Deloron, Quique Bassat, Patrick Sawa, David P. Hughes, Ishag Adam, Michel Van Herp, Christopher V. Plowe, Ghulam Rahim Awab, Caterina I. Fanello, Joel Tarning, Stephan Duparc, Jean Bosco Ouedraogo, Emmanuelle Espie, Tran Tinh Hien, Jean R. Kiechel, Anders Björkman, Abdoulaye Djimde, Billy E. Ngasala, Nahla B. Gadalla, Prabin Dahal, Kasia Stepniewska, Lars Rombo, Nhien Nguyen Thuy, Philippe J Guerin, Verena I. Carrara, Babacar Faye, Christophe Rogier, Peter G. Kremsner, Oumar Gaye, Inge Sutanto, Jean-Louis A Ndiaye, Bernhards Ogutu, Mary Oguike, Vincent Jullien, Jimee Hwang, Kevin Marsh, Djibrine Djalle, Ric N. Price, Yavo William, Georgina S Humphreys, WorldWide Antimalarial Resistance Network (WWARN), University of Oxford [Oxford]-Churchill Hospital Oxford Centre for Haematology, Neuroépidémiologie Tropicale (NET), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), Service des Maladies infectieuses et tropicales [CHU Limoges], CHU Limoges, Membranes et cibles thérapeutiques (MCT), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Recherche Biomédicale des Armées (IRBA), University of Oxford-Churchill Hospital Oxford Centre for Haematology, CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), Infectious diseases, AII - Infectious diseases, APH - Global Health, and APH - Quality of Care
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[SDV]Life Sciences [q-bio] ,Network Meta-Analysis ,Infektionsmedicin ,Plasmodium falciparum/drug effects ,Polymerase Chain Reaction ,0302 clinical medicine ,Dihydroartemisinin/piperaquine ,Recurrence ,Cumulative incidence ,030212 general & internal medicine ,Antimalarials/pharmacology ,Malaria, Falciparum ,biology ,Malaria, Falciparum/drug therapy ,food and beverages ,3. Good health ,Infectious Diseases ,Meta-analysis ,Regression Analysis ,Competing risk even ,Risk ,Treatment efficacy study ,Infectious Medicine ,medicine.medical_specialty ,lcsh:Arctic medicine. Tropical medicine ,lcsh:RC955-962 ,030231 tropical medicine ,Plasmodium falciparum ,Malària ,Competing risks ,lcsh:Infectious and parasitic diseases ,Antimalarials ,03 medical and health sciences ,Internal medicine ,parasitic diseases ,medicine ,Humans ,lcsh:RC109-216 ,business.industry ,Methodology ,medicine.disease ,biology.organism_classification ,Malaria ,Competing risk event ,Parasitology ,Tropical medicine ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,business - Abstract
Background Therapeutic efficacy studies in uncomplicated Plasmodium falciparum malaria are confounded by new infections, which constitute competing risk events since they can potentially preclude/pre-empt the detection of subsequent recrudescence of persistent, sub-microscopic primary infections. Methods Antimalarial studies typically report the risk of recrudescence derived using the Kaplan–Meier (K–M) method, which considers new infections acquired during the follow-up period as censored. Cumulative Incidence Function (CIF) provides an alternative approach for handling new infections, which accounts for them as a competing risk event. The complement of the estimate derived using the K–M method (1 minus K–M), and the CIF were used to derive the risk of recrudescence at the end of the follow-up period using data from studies collated in the WorldWide Antimalarial Resistance Network data repository. Absolute differences in the failure estimates derived using these two methods were quantified. In comparative studies, the equality of two K–M curves was assessed using the log-rank test, and the equality of CIFs using Gray’s k-sample test (both at 5% level of significance). Two different regression modelling strategies for recrudescence were considered: cause-specific Cox model and Fine and Gray’s sub-distributional hazard model. Results Data were available from 92 studies (233 treatment arms, 31,379 patients) conducted between 1996 and 2014. At the end of follow-up, the median absolute overestimation in the estimated risk of cumulative recrudescence by using 1 minus K–M approach was 0.04% (interquartile range (IQR): 0.00–0.27%, Range: 0.00–3.60%). The overestimation was correlated positively with the proportion of patients with recrudescence [Pearson’s correlation coefficient (ρ): 0.38, 95% Confidence Interval (CI) 0.30–0.46] or new infection [ρ: 0.43; 95% CI 0.35–0.54]. In three study arms, the point estimates of failure were greater than 10% (the WHO threshold for withdrawing antimalarials) when the K–M method was used, but remained below 10% when using the CIF approach, but the 95% confidence interval included this threshold. Conclusions The 1 minus K–M method resulted in a marginal overestimation of recrudescence that became increasingly pronounced as antimalarial efficacy declined, particularly when the observed proportion of new infection was high. The CIF approach provides an alternative approach for derivation of failure estimates in antimalarial trials, particularly in high transmission settings. Electronic supplementary material The online version of this article (10.1186/s12936-019-2837-4) contains supplementary material, which is available to authorized users.
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- 2019
13. [Comparison of the therapeutic efficiency and of the tolerance of the artemether-lumefantrine and artesunate-amodiaquine combination in Niger]
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Maman Laminou, Ibrahim, Fatouma, Sadou, Maman, Daou, Boubacar Mainassara, Halima, Maazou, Abani, Zamanka, Halima, Arzika, Ibrahim, Boubacar, Mahamadou, and Adehossi, Eric
- Abstract
Malaria is a major public health problem in Niger. The Global Fund to fight AIDS, Tuberculosis, and Malaria launched, in 2011, an initiative entitled "Affordable Medicines Facility - Malaria" or AMFm which aims to make artemisinin-based combination therapies (ACT) more available, more accessible and to eliminate the development of artemisinin resistance. It is in this context that we have conducted a randomized comparative double open-arm study of the efficacy and safety of artemether-lumefantrine (AL) and artesunate-amodiaquine (AM) in Gaya.The objective of the study is to evaluate and then to compare the efficiency and tolerance to these two combinations. The study was modeled with the WHO 2003, 28 days protocol.370 febrile patients were examined. 159 patients were included, where 79 (49.4%) were put in the AL arm and 81 (50.6%) were placed in the AM arm. The adequate clinical and parasitological response was 94.8% and 97.1% respectively for AL and AM. There was no statistical significant difference in efficiency between the two therapiesLe paludisme est un problème majeur de santé publique au Niger. Le Fonds Mondial de la lutte contre le sida, la tuberculose et le paludisme a lancé en 2011 une initiative appelée « Affordable Medecines Facility - Malaria” ou AMFm qui vise à rendre les combinaisons thérapeutiques à base d'artémisinine (CTA) plus disponibles, plus accessibles et de lutter contre la résistance à l'artémisinine. C'est dans ce contexte que nous avons mené une étude comparative, randomisée, à deux bras ouverts de l'efficacité thérapeutique des associations artémether-luméfantrine (AL) et artésunate-amodiaquine (AM) au niveau du site sentinelle de Gaya.L'objectif de l'étude est d'évaluer puis de comparer l'efficacité et la tolérance de ces deux CTA. La méthode utilisée est le protocole OMS/2003 avec le suivi de 28 jours.370 patients fébriles ont été examinés. 159 patients ont été inclus dont 79 (49.4%) pour le bras AL et 80 (50.3%) pour le bras AM. La réponse clinique et parasitologique adéquate est respectivement de 94.8% pour AL et 97.1% AM. Il n'y a pas de différence statistiquement significative d'efficacité entre les deux molécules
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- 2018
14. A Report of Four Cases of Blackwater Fever after Quinine Treatment at Zinder National Hospital, Niger Republic
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Mahamadou, Doutchi, primary, Hassane, Diongolé M., additional, Zeinabou, Moussa Tondi Maiga, additional, Aboubacar, Iliassou, additional, Osseini, Ali, additional, Harissou, Adamou, additional, Abdoul-Aziz, Garba, additional, Ibrahim, Alkassoum, additional, Maman Laminou, Ibrahim, additional, and Eric, Adéhossi, additional
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- 2019
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15. Cours National de Paludologie du Niger : Bilan de cinq ans
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Soumana Amadou, Hadiza Jakou, Sani Haladou, Mahamadou Izamne, Rabou Labbo, Mamane Abdou Oumarou, Maman Daou, Mahamadou Boubacar, Ibrahim Arzika, Maman Laminou Ibrahim, Lamine Mahaman Moustapha, and Eric Adehossi
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Formation, Paludisme, Bilan, Niger - Abstract
Le Cours National de Paludologie (CNP) est une formation organisee depuis 2011 par le Centre de Recherche Medicale et Sanitaire (CERMES) de Niamey en collaboration avec le Programme National de Lutte contre le Paludisme (PNLP) du Niger, la Faculte des Sciences de la Sante (FSS) de l’universite Abdoul Moumouni et l’Hopital National de Niamey. Objectif : L’objectif de ce cours est de renforcer l’aptitude des acteurs de la lutte contre le paludisme. Nous presentons le bilan de cinq ans d’animation du cours. Methodologie et resultats : La methodologie du cours est une approche interactive, basee sur le principe de l’andragogie et utilisant les nouvelles technologies de l’information et de la communication (NTIC). Cent quarante-six candidats ont postule au CNP en 5 ans. Soixante-seize candidats ont ete retenus par la commission de selection des dossiers. 97,4% des candidats etaient de nationalite Nigerienne. Le taux de reussite etait de 95,9% (N=74). Cinquante-trois conferences ont ete animees par des chercheurs seniors venus de 7 pays differents. La moyenne generale au pre test etait de 9,2/20 (D=6,2, [3 ; 16,5]) contre 14,9/20 (D=8,3 ; [7,5 ; 20]) au post test. L’analyse du questionnaire de satisfaction montre que 69,9% (N=44) des apprenants etaient satisfaits du cours. Conclusion : Le CNP s’est deroule avec beaucoup de satisfaction durant ces cinq annees consecutives. Les resultats d’evaluation de ce cours sont excellents. Le Reseau International des Instituts Pasteur (RIIP) auquel appartient le CERMES doit perenniser ce cours en le transformant en un cours sous regional denomme « Cours Ouest Africain de Paludologie (COAP) ». Mots cles : Formation, Paludisme, Bilan, Niger.
- Published
- 2017
16. Low Prevalence of Pfcrt Resistance Alleles among Patients with Uncomplicated Falciparum Malaria in Niger Six Years after Chloroquine Withdrawal
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Adamou Salissou, Brigitte Biyghe Binze, Thierry Fandeur, Halima Zamanka, Maman Laminou Ibrahim, Taiana Rivière, and Magalie Tichit
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Veterinary medicine ,Article Subject ,Epidemiology ,Haplotype ,Amodiaquine ,Biology ,medicine.disease ,lcsh:Infectious and parasitic diseases ,Infectious Diseases ,Data sequences ,Chloroquine ,parasitic diseases ,Genotype ,medicine ,lcsh:RC109-216 ,Artemisinin ,Allele ,Malaria ,Research Article ,medicine.drug - Abstract
Chloroquine (CQ) resistance is widespread in Africa, but few data are available for Niger. Pfcrt haplotypes (aa 56–118) and ex vivo responses to CQ and amodiaquine were characterized for 26 isolates collected in South Niger from children under 15 years of age suffering from uncomplicated falciparum malaria, six years after the introduction of artemisinin-based combinations and the withdrawal of CQ. The wild-type Pfcrt haplotype CVMNK was found in 22 of the 26 isolates, with CVIET sequences observed in only three of the samples. We also describe for the first time a new CVINT haplotype. The ex vivo responses were better for CVMNK than for CVIET parasites. Pfcrt sequence data were compared with those obtained for 26 additional parasitized blood samples collected in Gabon, from an area of CQ resistance used as a control. Our findings suggest that there has been a significant decline in CQ-resistant genotypes since the previous estimates for Niger were obtained. No such decline in molecular resistance to CQ was observed in the subset of samples collected in similar conditions from Gabon. These results have important implications for public health and support the policy implemented in Niger since 2005, which aims to increase the efficacy and availability of antimalarial drugs whilst controlling the spread of resistance.
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- 2014
17. A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms
- Author
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Benoit Witkowski, Hans-Peter Fuehrer, Garib Das Thakur, Céline Barnadas, Djibrine Djalle, Michael Ramharter, Mindy Leelawong, Wasif Ali-Khan, Harald Noedl, Bouasy Hongvanthong, Mohammad Shafiul-Alam, Hypolite Muhindo-Mavoko, Abdillahi Mohamed Hassan, Judith Straimer, Nimol Khim, Kigbafori D. Silué, Kaknika Loch, Barbara H. Stokes, Maria Dorina Bustos, Laura Berne, Dylan R. Pillai, Ayola A. Adegnika, Lin Hua Tang, Rotha Eam, Saorin Kim, Alioune Dieye, Mei Li, Carole E. Eboumbou-Moukoko, Lydie Canier, Marian Warsame, Didier Menard, David A. Fidock, Yap Boum, Lyndes Wini, Abdiqani Sheikh-Omar, Patrick Tshibangu-Wa-Tshibangu, Maman Laminou Ibrahim, Mohammad Jahirul-Karim, Malen Ken, Monique A. Dorkenoo, Sócrates Herrera, Odile Mercereau-Puijalon, Lise Musset, Valentine Duru, Eric Legrand, Maniphone Khanthavong, Pascal Ringwald, Bruno Pradines, Sandrine Houzé, Rachida Tahar, Olukemi K. Amodu, Johann Beghain, Sandie Menard, Liwang Cui, Colin J. Sutherland, Jun Hu Chen, Kesara Na-Bangchang, Khin Lin, Michael Nambozi, Rithea Leang, Jean Christophe Barale, Milijaona Randrianarivelojosia, Marcus V. G. Lacerda, Sophy Chy, Frédéric Ariey, Jean-Bosco Ouédraogo, Isabelle Morlais, Maria de Fátima Ferreira-da-Cruz, Lubin Jiang, Christophe Rogier, Jun Cao, Peter G. Kremsner, Bui Quang-Phuc, Inès Vigan-Womas, Din Syafruddin, Jetsumon Sattabongkot, Shigeyuki Kano, Abebe A. Fola, Louis Collet, Karamoko Niaré, Thierry Fandeur, Sedigheh Zakeri, Sodiomon B. Sirima, Antoine Berry, Jean Baptiste Mazarati, Fe Espino, Ghulam Rahim-Awab, Chanra Khean, Offianan Andre Toure, Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP), Génétique et Génomique des Insectes vecteurs, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Eberhard Karls Universität Tübingen = Eberhard Karls University of Tuebingen, Centre de Recherche Médicale de Lambaréné, Albert Schweitzer, Leiden University Medical Center (LUMC), Universiteit Leiden, International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), University of Ibadan, Nangarhar University, Mahidol University [Bangkok], The Walter and Eliza Hall Institute of Medical Research (WEHI), University of Melbourne, Papua New Guinea Institute for Medical Research (PNGIMR), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Mbarara University of Science and Technology [Mbarara] (MUST), Epicentre Ouganda [Mbarara] [Médecins Sans Frontières], Epicentre [Paris] [Médecins Sans Frontières], World Health Organization (WHO), country office for Thailand, Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), JiangSu University, National Institute of Parasitic Diseases, Center for Disease Control, China, Centre Hospitalier de Mayotte, Pennsylvania State University (Penn State), Penn State System, Epidemiology and Disease Control division (EDCD), Ministry of Public Health [Nepal], Institut Pasteur de Dakar, Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD), Institut Pasteur de Bangui, Université de Lomé [Togo], Université de Douala, Centre Pasteur du Cameroun, Research Institute for Tropical Medicine, Centre International de Recherches Médicales de Franceville (CIRMF), Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ), University of Gondar, Institute of Parasitology [Vienna], University of Veterinary Medicine, Vienna, World Health Organisation (WHO), country office for Somalia, Caucaseco scientific research center = Centro de Investigación Científica Caucaseco, National Center for Malariology, Parasitology and Entomology, Ministry of Health [Mozambique], Hôpital Bichat - Claude Bernard, Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique (MERIT - UMR_D 216), Institut de Recherche pour le Développement (IRD)-Université Paris Descartes - Paris 5 (UPD5), Centre de Recherche Médicale et Sanitaire (Niamey, Niger) (CERMES), Directorate General of Health Services (DGHS), Institut Pasteur de Shanghai, Académie des Sciences de Chine - Chinese Academy of Sciences (IPS-CAS), National Center for Global Health and Medicine [Japan] (NCGM), Institut Pasteur du Laos, Instituto Leônidas e Maria Deane - Fiocruz Amazônia [Manaus, Brésil] (ILMD), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Fundação de Medicina Tropical Doutor Heitor Vieira Dourado (FMT-HVD), National Center for Malaria Control, Parasitology and Entomology, Ministry of Health of Cambodgia, Henry M. Jackson Foundation for the Advancement of Military Medicine (HJM), U.S. Naval Medical Research, The Department of Medical Research (Upper Myanmar), Rwanda Biomedical Center (RBC), Centre de Physiopathologie Toulouse Purpan (CPTP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche pour le Développement [Yaoundé, Cameroun] (IRD [Cameroun]), Institut de Recherche pour le Développement (IRD), University of Kinshasa (UNIKIN), University of Antwerp (UA), Institut Pasteur de la Guyane, Thammasat University (TU), Tropical Diseases Research Center (TDRC), Université de Bamako, Medizinische Universität Wien = Medical University of Vienna, Institut de Recherche en Sciences de la Santé (IRSS) / Centre Muraz, Medicines for Malaria Venture (MMV), Université de Genève = University of Geneva (UNIGE), Global Malaria Programme, Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre National de Référence du Paludisme, Institut Pasteur de Madagascar, Ministry of Health and Human Services [Somalia], Centre Suisse de Recherches Scientifiques en Cote d'Ivoire [Abidjan] (CSRS-CI), Université Félix Houphouët-Boigny (UFHB), Groupe de recherche action en santé (GRAS), London School of Hygiene and Tropical Medicine (LSHTM), University of Hasanuddin, Eijkman Institute for Molecular Biology [Jakarta], Institut Pasteur de Côte d'Ivoire, Ministry of Health and Medical Services, Institut Pasteur d'Iran, Centre National de Référence du Paludisme [Cayenne, Guyane française] (CNR - laboratoire associé), Microbiologie structurale - Structural Microbiology (Microb. Struc. (UMR_3528 / U-Pasteur_5)), Institut Pasteur [Paris] (IP)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Columbia University Irving Medical Center (CUIMC), Institut de Recherche Biomédicale des Armées [Antenne Marseille] (IRBA), AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Descartes - Paris 5 (UPD5), Supported by the Institut Pasteur Paris, Institut Pasteur International Division, Institut Pasteur Cambodia, and the World Health Organization, by a grant (ANR-10-LABX-62-IBEID) from the French Government Investissement d’Avenir program, Laboratoire d’Excellence 'Integrative Biology of Emerging Infectious Diseases', a grant from Natixis Banques, a grant (R01I109023, to Dr. Fidock) from the National Institutes of Health, grants from the Fiocruz Fundação Oswaldo Cruz, Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro, Fundação de Amparo à Pesquisa do Estado do Amazonas, the Brazilian National Council for Scientific and Technological Development, the Agence Nationale de la Recherche (13-BSV3-0018-01 and11-BSV7-009-01), the Austrian Federal Ministry of Science, Research, and Econo-my, the Calgary Laboratory Services, the Centre International de Recherches Médicales de Franceville, the European and Developing Countries Clinical Trials Partnership (CT-2004-31070-001), the Drugs for Neglected Diseases Initiative, the Else Kroener Fresenius Stiftung, the Holger Poehlmann Stiftung, the European Community African–European Research Initiative 'IDEA' (HEALTH-F3-2009-241642), the Fonds Wetenschappelijk Onderzoek, the Vlaamse Interuniversitaire Raad–Universitaire Ontwikkelingssamenwerking, the Belgian Technical Cooperation in Democratic Republic of Congo, the European Community Seventh Framework Program (FP7/2007-2013, 242095, and 223601), the European Commission (REGPOT-CT-2011-285837-STRONGER), the Ministère de la Santé Publique du Niger (Laboratoire National de Référence Résistance aux Antipaludiques), the Foundation of National Science and Technology Major Program (2012ZX10004-220), the French Ministry of Health (Institut National de Veille Sanitaire), the Global Fund to Fight AIDS, Tuberculosis and Malaria, the 5% Initiative program (French Ministry of Foreign Affairs, France Expertise Internationale, 12INI109), the Institut Pasteur de Madagascar, the Government of the Philippines, the Institut de Recherche pour le Développement, the Foundation des Treilles, the Délégation Générale pour l’Armement (PDH-2-NRBC-4-B1-402), the Institut Pasteur de Bangui, the International Society for Health Research and Training, the Malaria Research Initiative Bandarban, Vienna, International Centre for Diarrhoeal Disease Research, Bangladesh, the Médecins sans Frontières (Centre Opérationnel Paris, France), Medicines for Malaria Venture, the National Research Council of Thailand, the Thammasat University, the National Natural Science Foundation of China (81271870, 81361120405, and 81271863), the Natural Science Foundation of Jiangsu Province (BK20130114 and BK20150001), the Jiangsu Science and Technology Department (BM2015024), the National Institutes of Health (R01 AI11646601, AI109023, and ICEMR U19AI089702, U19AI089672), the Pasteur Institute of Iran, the Malaria Division of the Iranian Center for Diseases Management and Control, Public Health England (Malaria Reference Service Contract), the Government of Rwanda, the U.S. Department of Defense Armed Forces Health Surveillance Center, Global Emerging Infections Surveillance and Response System (P0463-14-N6), the Fogarty International Center of the National Institutes of Health training (D43 TW007393), the Mahidol-Oxford Research Unit, the Government of Japan (Science and Technology Agency, Agency for Medical Research and Development, Japan International Cooperation Agency, and Science and Technology Research Partnership for Sustainable Development), and the President’s Malaria Initiative of the U.S. Agency for International Development., The KARMA Consortium, ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), ANR-13-BSV3-0018,MALARTRES,Résistance de Plasmodium aux antipaludiques de la famille des artémisinines(2013), ANR-13-BSV7-0009,NEBEDIV,Le rôle des ennemis naturels dans la diversité béta des arbres tropicaux(2013), European Project: CT-2004-31070-001,EDCCTP, European Project: HEALTH-F3-2009-24164,IDEA, European Project: FP7/2007-2013, 24209,FP7, European Project: FP7/2007-2013, 22360,FP7, European Project: 285837,EC:FP7:REGPOT,FP7-REGPOT-2011-1,STRONGER(2011), European Project: 242095,EC:FP7:HEALTH,FP7-HEALTH-2009-single-stage,EVIMALAR(2009), European Project: 223601,EC:FP7:HEALTH,FP7-HEALTH-2007-B,MALVECBLOK(2009), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), CHU Toulouse [Toulouse], Fundação Oswaldo Cruz (FIOCRUZ), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Genève (UNIGE), INSB-INSB-Centre National de la Recherche Scientifique (CNRS), Centre National de Référence du Paludisme [Cayenne, Guyane française] (CNR), Université Paris Diderot - Paris 7 (UPD7)-Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Eberhard Karls Universität Tübingen, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia., Centre International de Recherches Médicales de Franceville, Caucaseco scientific research center, Mère et enfant face aux infections tropicales (MERIT - UMR_D 216), National Center for Global Health and Medicine (NCGM), Instituto Leônidas e Maria Deane (ILMD), Centre de Physiopathologie Toulouse Purpan ex IFR 30 et IFR 150 (CPTP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche pour le Développement [Yaoundé], Centre Suisse de Recherches Scientifiques en Côte d'Ivoire, Eijkman Institute for Molecular Biology, Laboratoire de Parasitologie, Centre National de Référence du Paludisme - Région Antilles-Guyane, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-WHO Collaborating Center for Surveillance of Antimalarial Drug Resistance, Institut Pasteur [Paris]-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), ANR-10-LABX-62-IBEID,IBEID,Laboratoire d'Excellence 'Integrative Biology of Emerging Infectious Diseases'(2010), Van geertruyden, Jean-Pierre, and KARMA Consortium
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0301 basic medicine ,Nonsynonymous substitution ,MESH: Sequence Analysis, DNA ,Endemic Diseases ,MESH: Asia, Southeastern ,Drug Resistance ,Protozoan Proteins ,Drug resistance ,MESH: Genotype ,Lactones ,0302 clinical medicine ,Genotype ,Artemisinin ,Malaria, Falciparum ,MESH: Protozoan Proteins ,Asia, Southeastern ,MESH: Plasmodium falciparum ,Genetics ,biology ,MESH: Malaria, Falciparum ,General Medicine ,Artemisinins ,MESH: China ,3. Good health ,MESH: Endemic Diseases ,MESH: Drug Resistance ,Algorithms ,MESH: Lactones ,medicine.drug ,China ,MESH: Mutation ,030231 tropical medicine ,030106 microbiology ,Plasmodium falciparum ,MESH: Algorithms ,03 medical and health sciences ,parasitic diseases ,MESH: Artemisinins ,MESH: Polymorphism, Genetic ,medicine ,Humans ,[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology ,Allele ,Polymorphism, Genetic ,MESH: Humans ,Haplotype ,Sequence Analysis, DNA ,medicine.disease ,biology.organism_classification ,Virology ,Mutation ,Human medicine ,Malaria - Abstract
Comment inK13-Propeller Mutations and Malaria Resistance, http://www.nejm.org/doi/full/10.1056/NEJMe1604520; International audience; BACKGROUND:Recent gains in reducing the global burden of malaria are threatened by the emergence of Plasmodium falciparum resistance to artemisinins. The discovery that mutations in portions of a P. falciparum gene encoding kelch (K13)-propeller domains are the major determinant of resistance has provided opportunities for monitoring such resistance on a global scale.METHODS:We analyzed the K13-propeller sequence polymorphism in 14,037 samples collected in 59 countries in which malaria is endemic. Most of the samples (84.5%) were obtained from patients who were treated at sentinel sites used for nationwide surveillance of antimalarial resistance. We evaluated the emergence and dissemination of mutations by haplotyping neighboring loci.RESULTS:We identified 108 nonsynonymous K13 mutations, which showed marked geographic disparity in their frequency and distribution. In Asia, 36.5% of the K13 mutations were distributed within two areas--one in Cambodia, Vietnam, and Laos and the other in western Thailand, Myanmar, and China--with no overlap. In Africa, we observed a broad array of rare nonsynonymous mutations that were not associated with delayed parasite clearance. The gene-edited Dd2 transgenic line with the A578S mutation, which expresses the most frequently observed African allele, was found to be susceptible to artemisinin in vitro on a ring-stage survival assay.CONCLUSIONS:No evidence of artemisinin resistance was found outside Southeast Asia and China, where resistance-associated K13 mutations were confined. The common African A578S allele was not associated with clinical or in vitro resistance to artemisinin, and many African mutations appear to be neutral. (Funded by Institut Pasteur Paris and others.).
- Published
- 2016
18. Field-based evidence for the linkage of pfcrt and pfdhfr drug-resistant malaria genotypes and clinical profiles of severe malaria in Niger
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Milijaona Randrianarivelojosia, Eric Adehossi, Veronique Lacroix, Jean-Bernard Duchemin, Maman Laminou Ibrahim, and Françoise Gay-Andrieu
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Genotype ,Anemia ,Plasmodium falciparum ,Immunology ,Drug Resistance ,Protozoan Proteins ,Virulence ,Drug resistance ,Microbiology ,Cohort Studies ,Antimalarials ,parasitic diseases ,medicine ,Animals ,Humans ,Niger ,Malaria, Falciparum ,biology ,Infant ,Membrane Transport Proteins ,medicine.disease ,biology.organism_classification ,Infectious Diseases ,Cerebral Malaria ,Child, Preschool ,Mutation ,Malaria ,Cohort study - Abstract
Drug resistance has been shown to increase malaria mortality and morbidity in both community- and hospital-based studies. We investigated the association between two Plasmodium falciparum drug resistance-related molecular markers and clinical profiles of severe malaria in children hospitalised in Niger. PCR-RFLP analysis showed that the codon 108 mutation of the pfdhfr gene was positively linked to severe malarial anaemia. These findings are consistent with persistent parasite infection leading to unbalanced anaemia in young children. No significant relationship was found between the molecular markers and hypoglycaemia or hyperparasitaemia. Conversely, the pfcrt T76 mutation was found to be negatively associated with cerebral malaria and neurological symptoms, such as convulsions and coma. These results have implications for the strain-specific virulence hypothesis and for parasite fitness and evolution. Our findings are discussed in regard to the local malaria transmission level.
- Published
- 2007
19. Perception de la chimioprévention du paludisme saisonnier au Niger
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Maman Laminou Ibrahim, Bako Yerima, Issa Salissou, Djakou Hadiza, Ibrahim Alkassoum, and Lamine Mahaman Moustapha
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03 medical and health sciences ,0302 clinical medicine ,030231 tropical medicine ,030212 general & internal medicine ,Enquête, perception, chimioprévention du paludisme saisonnier, Niger, Perception, seasonal malaria chemoprevention, Niger - Abstract
La chimioprevention du paludisme saisonnier (CSP) est une nouvelle strategie recommandee par l’Organisation Mondiale de la Sante (OMS) depuis mars 2012 aux pays ou la transmission du paludisme est saisonniere. Le programme national de lutte contre le paludisme (PNLP) du Niger a initie une etude pilote en 2013 au niveau du district sanitaire de Magaria avec l’appui de Medecins Sans Frontieres (MSF) avant sa mise a l’echelle nationale. C’est dans ce contexte qu’une enquete a ete menee pour evaluer la perception de la CPS par la population a Magaria. Quatre-vingt-quatre pourcents des parents sont satisfaits de la chimioprevention du paludisme saisonnier. Le taux de couverture de la CPS (4 passages) est de 81,3%. Quatre-vingt-neuf virgule deux pourcents ont respecte l’observance du traitement. Aucun evenement indesirable majeur n’a ete enregistre. Cependant, 27.8% des enfants ont manifeste des evenements indesirables mineurs. Les principales manifestations sont la diarrhee (53,7%) et le vomissement (38,8%). La CPS est une strategie acceptee par la population. Le taux de couverture et l’observance du traitement sont tres eleves et les effets secondaires sont mineurs. Au vu de ces resultats, le programme national de lutte contre le paludisme peut mettre en oeuvre la CPS a l’echelle nationale. © 2016 International Formulae Group. All rights reserved. Mots cles: Enquete, perception, chimioprevention du paludisme saisonnier, Niger English Title: Perception of the seasonal malaria chemoprevention in Niger English Abstract Seasonal Malaria Chemoprevention (SMC) is a new strategy recommended by the World Health Organization since March 2012 for countries with seasonal malaria transmission. The National Malaria Control Programme (NMCP) of Niger has initiated a pilot study in the health district of Magaria in children of 3-59 months, with the support of Medecins Sans Frontieres. In this context, we have conducted a questionnaire to assess how the population perceives the implementation of SMC. By 241 parents, 84% of parents are satisfied with seasonal malaria chemoprevention. SMC coverage (4 cycles) was 81.3% and 89.2% complied with treatment adherence. No severe adverse effect was recorded. However, 27.8% of the children showed minor adverse effects. The main adverse effects reported were diarrhea (53.7%) and vomiting (38.8%). SMC is a strategy well accepted by the population and the coverage and treatment compliance are very high. The adverse effects are also minor. SMC could be implemented at a larger scale in Niger by the NMCP. © 2016 International Formulae Group. All rights reserved. Keywords: Perception, seasonal malaria chemoprevention, Niger
- Published
- 2017
20. A refined estimate of the malaria burden in Niger
- Author
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Florian Girond, Halima Zamanka, Binta Boubacar, Thierry Fandeur, Ibrahim Ouba, Ibrahim Arzika, Aboubacar Mahamadou, Ramatoulaye Hamidou Lazoumar, Abani Maazou, Maman Laminou Ibrahim, Rabiou Labbo, Julia Guillebaud, Seydou Maiguizo, and Maimouna Halidou Doudou
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Male ,Psychological intervention ,Rapid tests ,Health care ,Epidemiology ,Diagnosis ,Niger ,Malaria, Falciparum ,Child ,Microscopy ,biology ,Incidence (epidemiology) ,Data Collection ,Incidence ,Infectious Diseases ,Child, Preschool ,Female ,Seasons ,Adult ,Quality Control ,Spatial variations ,medicine.medical_specialty ,lcsh:Arctic medicine. Tropical medicine ,Adolescent ,Fever ,lcsh:RC955-962 ,Plasmodium falciparum ,Seasonal variations ,Sensitivity and Specificity ,lcsh:Infectious and parasitic diseases ,Diagnosis, Differential ,Environmental health ,parasitic diseases ,medicine ,Humans ,lcsh:RC109-216 ,business.industry ,Diagnostic Tests, Routine ,Public health ,Research ,Infant, Newborn ,Infant ,Monitoring and evaluation ,Seasonality ,medicine.disease ,biology.organism_classification ,Surgery ,Malaria ,Slide positivity rate ,Parasitology ,Morbidity ,business - Abstract
Background The health authorities of Niger have implemented several malaria prevention and control programmes in recent years. These interventions broadly follow WHO guidelines and international recommendations and are based on interventions that have proved successful in other parts of Africa. Most performance indicators are satisfactory but, paradoxically, despite the mobilization of considerable human and financial resources, the malaria-fighting programme in Niger seems to have stalled, as it has not yet yielded the expected significant decrease in malaria burden. Indeed, the number of malaria cases reported by the National Health Information System has actually increased by a factor of five over the last decade, from about 600,000 in 2000 to about 3,000,000 in 2010. One of the weaknesses of the national reporting system is that the recording of malaria cases is still based on a presumptive diagnosis approach, which overestimates malaria incidence. Methods An extensive nationwide survey was carried out to determine by microscopy and RDT testing, the proportion of febrile patients consulting at health facilities for suspected malaria actually suffering from the disease, as a means of assessing the magnitude of this problem and obtaining a better estimate of malaria morbidity in Niger. Results In total, 12,576 febrile patients were included in this study; 57% of the slides analysed were positive for the malaria parasite during the rainy season, when transmission rates are high, and 9% of the slides analysed were positive during the dry season, when transmission rates are lower. The replacement of microscopy methods by rapid diagnostic tests resulted in an even lower rate of confirmation, with only 42% of cases testing positive during the rainy season, and 4% during the dry season. Fever alone has a low predictive value, with a low specificity and sensitivity. These data highlight the absolute necessity of confirming all reported malaria cases by biological diagnosis methods, to increase the accuracy of the malaria indicators used in monitoring and evaluation processes and to improve patient care in the more remote areas of Niger. This country extends over a large range of latitudes, resulting in the existence of three major bioclimatic zones determining vector distribution and endemicity. Conclusion This survey showed that the number of cases of presumed malaria reported in health centres in Niger is largely overestimated. The results highlight inadequacies in the description of the malaria situation and disease risk in Niger, due to the over-diagnosis of malaria in patients with simple febrile illness. They point out the necessity of confirming all cases of suspected malaria by biological diagnosis methods and the need to take geographic constraints into account more effectively, to improve malaria control and to adapt the choice of diagnostic method to the epidemiological situation in the area concerned. Case confirmation will thus also require a change in behaviour, through the training of healthcare staff, the introduction of quality control, greater supervision of the integrated health centres, the implementation of good clinical practice and a general optimization of the use of available diagnostic methods.
- Published
- 2012
21. Polymorphism of PfATPase in Niger: detection of three new point mutations
- Author
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Frédéric Ariey, Maman Laminou Ibrahim, Hassane Hadiza Adam, Nimol Khim, and Jean-Bernard Duchemin
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Male ,lcsh:Arctic medicine. Tropical medicine ,Combination therapy ,Adolescent ,Sulfadoxine ,lcsh:RC955-962 ,medicine.medical_treatment ,Plasmodium falciparum ,Drug Resistance ,Drug resistance ,Calcium-Transporting ATPases ,Pharmacology ,Polymerase Chain Reaction ,lcsh:Infectious and parasitic diseases ,Antimalarials ,Chloroquine ,parasitic diseases ,medicine ,Prevalence ,Animals ,Humans ,Point Mutation ,lcsh:RC109-216 ,Artemether ,Niger ,Artemisinin ,Malaria, Falciparum ,Child ,Codon ,Polymorphism, Genetic ,biology ,Research ,Sequence Analysis, DNA ,biology.organism_classification ,medicine.disease ,Virology ,Infectious Diseases ,Child, Preschool ,Parasitology ,Malaria ,medicine.drug - Abstract
Background Plasmodium falciparum resistance to drugs remains a major public health issue in Niger. The therapeutic failure index for chloroquine and sulphadoxine-pyrimethamine are, respectively 20% and 21.9%. In December 2005, the National Malaria Control Programme promoted the use of artemisinin combination therapy (ACT) as first-line treatment of the uncomplicated malaria cases. Recently, studies have shown a relationship between the SERCA PfATPase6 gene and artemisinin efficacy, and pointed it out as a potential molecular marker for resistance. The goal of this work was to describe the baseline polymorphism of PfATPase6 gene in Niger, at a time when the national implementation of the ACT policy had just begun. Materials and methods The DNA polymorphism of the PfATPase6 gene of 87 P. falciparum samples from Niger was analysed by sequencing. The links between the mutation occurrence and environment and human host factors were tested by bivariate analysis. Results The P. falciparum PfATPase6 gene presented polymorphisms at codons 537, 561, 569, 630, 639, 716 levels. All the mutations found were rare, except the PfATPaseN569K found in 17.2% of samples. No associated factor has been observed. Conclusion The P. falciparum PfATPase gene is polymorphic at the 569 codon. As ACT is getting more and more used, the PfATPase6 gene polymorphism needs to be monitored in association with phenotypic – in vivo and/or in vitro – drug efficacy tests.
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- 2009
22. Field-based evidence of fast and global increase of Plasmodium falciparum drug-resistance by DNA-microarrays and PCR/RFLP in Niger
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Jean-Bernard Duchemin, Nimol Khim, Lassana Konate, Hadiza Hassane Adam, Nicolas Steenkeste, Maman Laminou Ibrahim, Frédéric Ariey, and Jean-Yves Coppée
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Male ,lcsh:Arctic medicine. Tropical medicine ,Adolescent ,lcsh:RC955-962 ,Plasmodium falciparum ,Drug Resistance ,Protozoan Proteins ,Drug resistance ,Biology ,Polymerase Chain Reaction ,Polymorphism, Single Nucleotide ,law.invention ,lcsh:Infectious and parasitic diseases ,Antimalarials ,Young Adult ,law ,parasitic diseases ,medicine ,Animals ,Humans ,lcsh:RC109-216 ,Artemether ,Niger ,Artemisinin ,Malaria, Falciparum ,Child ,Polymerase chain reaction ,Oligonucleotide Array Sequence Analysis ,Genetics ,Research ,DNA, Protozoan ,medicine.disease ,biology.organism_classification ,Infectious Diseases ,Parasitology ,Mutation ,Female ,Restriction fragment length polymorphism ,Malaria ,Polymorphism, Restriction Fragment Length ,medicine.drug - Abstract
Background Over the last years, significant progress has been made in the comprehension of the molecular mechanism of malaria resistance to drugs. Together with in vivo tests, the molecular monitoring is now part of the survey strategy of the Plasmodium sensitivity. Currently, DNA-microarray analysis allows the simultaneous study of many single nucleotide polymorphisms (SNP) of Plasmodium isolates. In December 2005, the International Federation of the Red Cross distributed two million three hundred thousand long-lasting insecticide nets to pregnant women and mothers of under five years children in the whole Niger. Then, Niger adopted artemisinin-based combination therapy as first-line treatment. Methods Thirty four SNPs of pfcrt, pfdhfr, pfdhps, pfmdr and pfATPase were analysed by DNA-microarray and PCR/RFLP in two villages – Zindarou and Banizoumbou – with different durations of malaria transmission. The main objective of the study was to measure the dynamics of Plasmodium falciparum resistant strains and associated factors. Results This study shows a global and clear increase of the drug-resistance associated molecular markers frequencies during a relatively short-time period of four years. Markers associated with resistance to chloroquine and sulphonamids were more frequently found in the short transmission zone than in the long transmission one. The pfcrt76T mutation is significantly more present at Banizoumbou than Zindarou (38.3% vs 25.2%, p = 0.013). This work allowed the screening of several field strains for five SNPs of PfATPase6 gene. The pfATPase6S769N, candidate mutation of resistance to artemisinin was not found. However the pfATPsaeA623E mutation was found in 4.7% of samples. Conclusion A significant increase of several SNPs frequencies was highlighted over a four-year period. The polymorphism of five PfATPase6 gene SNPs was described. The global, large and fast increase of the molecular resistance is discussed in the context of current changes of health policy and malaria control in Niger.
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- 2008
23. Controlling schistosomiasis: significant decrease of anaemia prevalence one year after a single dose of praziquantel in Nigerian schoolchildren
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Maman-Laminou Ibrahim, Elisa Bosqué-Oliva, Amadou Garba, Ali E. Mahamane, Halima Boubacar Maïnassara, Pascal Boisier, Zilahatou Tohon, Suzanne Chanteau, Jean-Bernard Duchemin, Centre de Recherche Médicale et Sanitaire (Niamey, Niger) (CERMES), Réseau International des Instituts Pasteur (RIIP), Programme National de Lutte contre la Bilharziose et les Géohelminthes, Schistosomiasis Control Initiative, Imperial College London, Institut Pasteur de Nouvelle-Calédonie, and Centre Pasteur du Cameroun
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Male ,MESH: Anemia ,Pediatrics ,Treatment outcome ,Public Health and Epidemiology/Infectious Diseases ,Praziquantel ,0302 clinical medicine ,MESH: Child ,Schistosomiasis ,030212 general & internal medicine ,Child ,MESH: Treatment Outcome ,Anthelmintics ,2. Zero hunger ,lcsh:Public aspects of medicine ,Anemia ,3. Good health ,MESH: Anthelmintics ,[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology ,Treatment Outcome ,Infectious Diseases ,MESH: Schistosomiasis ,Hematology/Anemias ,Female ,MESH: Nigeria ,Research Article ,medicine.drug ,Infectious Diseases/Epidemiology and Control of Infectious Diseases ,Single administration ,medicine.medical_specialty ,lcsh:Arctic medicine. Tropical medicine ,lcsh:RC955-962 ,030231 tropical medicine ,Nigeria ,Albendazole ,03 medical and health sciences ,parasitic diseases ,medicine ,Humans ,Helminths ,Infectious Diseases/Helminth Infections ,MESH: Humans ,business.industry ,MESH: Praziquantel ,Infectious Diseases/Protozoal Infections ,Public Health, Environmental and Occupational Health ,lcsh:RA1-1270 ,medicine.disease ,MESH: Male ,Infectious Diseases/Neglected Tropical Diseases ,Schistosoma haematobium infection ,Immunology ,business ,MESH: Female - Abstract
Background In the framework of the monitoring and evaluation of the Nigerien schistosomiasis and soil-transmitted helminth control programme, a follow-up of children took place in eight sentinel sites. The objective of the study was to assess the evolution of Schistosoma haematobium infection and anaemia in schoolchildren after a single administration of praziquantel (PZQ) and albendazole. Methods/Principal Findings Pre-treatment examination and follow-up at one year post-treatment of schoolchildren aged 7, 8, and 11 years, including interview, urine examination, ultrasound examination of the urinary tract, and measurement of haemoglobin. Before treatment, the overall prevalence of S. heamatobium infection was 75.4% of the 1,642 enrolled children, and 21.8% of children excreted more than 50 eggs/10 ml urine. Prevalence increased with age. The overall prevalence of anaemia (haemoglobin, Author Summary The World Health Organization's recommendation for the control of urinary schistosomiasis is to reduce morbidity by reducing the prevalence of heavy infections. In Niger, where urinary schistosomiasis is endemic along the Niger River valley and in proximity to ponds, a national control programme for schistosomiasis and soil-transmitted helminth was launched in 2004 with the financial support of the Gates Foundation through the Schistosomiasis Control Initiative. In the framework of the monitoring and evaluation of the control programme, a follow-up of school children took place in eight sentinel sites. The aim of this study was to assess the evolution of Schistosoma haematobium infection and associated morbidity after a single-dose administration of praziquantel and albendazole. Before treatment, the overall prevalence of S. heamatobium infection was 75.4% and anaemia (haemoglobin
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- 2008
24. [Untitled]
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Moussa Gagara, Eric Adehossi, Françoise Gay-Andrieu, Hama Kourna, Maman Laminou Ibrahim, Veronique Lacroix, and Hamadou Boureima
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Integrated Management of Childhood Illness ,medicine.medical_specialty ,education.field_of_study ,Pediatrics ,Referral ,business.industry ,Public health ,Population ,Context (language use) ,medicine.disease ,Infectious Diseases ,Environmental health ,parasitic diseases ,Epidemiology ,Tropical medicine ,Medicine ,Parasitology ,business ,education ,Malaria - Abstract
Background Malaria takes a heavy toll in Niger, one of the world's poorest countries. Previous evaluations conducted in the context of the strategy for the Integrated Management of Childhood Illness, showed that 84% of severe malaria cases and 64 % of ordinary cases are not correctly managed. The aim of this survey was to describe epidemiological, clinical and biological features of malaria among
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- 2005
25. Epidemiology of malaria in an area of seasonal transmission in Niger and implications for the design of a seasonal malaria chemoprevention strategy
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Maman Laminou Ibrahim, Thierry Fandeur, Ibrahim Arzika, Jean-Bernard Duchemin, Aboubacar Mahamadou, Pierre Druilhe, Rabiou Labbo, Mariama Katzelma, Elfatih A. B. Eltahir, Halima Zamanka, Julia Guillebaud, Massachusetts Institute of Technology. Department of Civil and Environmental Engineering, Parsons Laboratory for Environmental Science and Engineering (Massachusetts Institute of Technology), Eltahir, Elfatih A. B., Unité de Parasitologie, Centre de Recherche Médicale et Sanitaire (Niamey, Niger) (CERMES), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Institut Pasteur de Madagascar, Réseau International des Instituts Pasteur (RIIP), MIT Parsons Laboratory, Massachusetts Institute of Technology (MIT), Vac4all initiative, Australian Animal Health (AAHL), Laboratory of CSIRO, Unité de Parasitologie Médicale, and Centre International de Recherches Médicales de Franceville (CIRMF)
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Male ,0302 clinical medicine ,Risk Factors ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Epidemiology ,Prevalence ,Medicine ,Niger ,030212 general & internal medicine ,Child ,Aged, 80 and over ,2. Zero hunger ,education.field_of_study ,Incidence ,Incidence (epidemiology) ,Age Factors ,Middle Aged ,3. Good health ,Infectious Diseases ,Child, Preschool ,Carrier State ,Population study ,Female ,Seasons ,Adult ,medicine.medical_specialty ,Adolescent ,030231 tropical medicine ,Population ,Chemoprevention ,Antimalarials ,Young Adult ,03 medical and health sciences ,parasitic diseases ,Gametocyte ,Humans ,education ,Aged ,business.industry ,Research ,Infant ,Seasonality ,medicine.disease ,Malaria ,Asymptomatic Diseases ,Slide positivity rate ,Tropical medicine ,Immunology ,Parasitology ,business ,Asymptomatic carrier ,Demography - Abstract
Background: Few data are available about malaria epidemiological situation in Niger. However, implementation of new strategies such as vaccination or seasonal treatment of a target population requires the knowledge of baseline epidemiological features of malaria. A population-based study was conducted to provide better characterization of malaria seasonal variations and population groups the most at risk in this particular area. Methods: From July 2007 to December 2009, presumptive cases of malaria among a study population living in a typical Sahelian village of Niger were recorded, and confirmed by microscopic examination. In parallel, asymptomatic carriers were actively detected at the end of each dry season in 2007, 2008 and 2009. Results: Among the 965 presumptive malaria cases recorded, 29% were confirmed by microscopic examination. The incidence of malaria was found to decrease significantly with age (p, France. Ministère des affaires étrangères, Institut Pasteur International Network
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