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In the present study, the effect of different ratios of GelMA concentration has been exhibited for wound dressing implementation by the electrospinning method using a new polymer combination of Gelatin methacrylate (GelMA)/Polycaprolactone (PCL)/Chitosan (CS). The nanofiber composites were fabricated due to their biocompatible, biodegradable, improved mechanical strength, low degradation rate, and hydrophilic nature to develop cell-mimicking, cell adhesion, proliferation, and differentiation. Different concentrations of GelMA were added to the PCL/CS solution as 5, 10, and 20 wt%, respectively, in the formic acid/acetic acid (7:3) solution. A photoinitiator was added to the solution for photo-crosslinking of GelMA. The influence of different solution concentrations (5, 10, and 20 wt%) on the structure’s nanofiber production and fiber morphology was examined. SEM micrographs revealed that varied GelMA concentrations resulted in suitable and stable nanofiber composites. The average diameter of nanofiber composites grows as the GelMA concentration rises. FTIR, DSC, tensile test, degradation, and swelling test were evaluated. The results demonstrated that high mechanical strength, hydrophilic properties, and a slow degradation rate were observed with the presence and increment of GelMA concentration within the nanofiber composites. The antibacterial potential of GelMA/PCL/CS nanofiber composites was evaluated against P. aeruginosa and S. aureus using a disc diffusion assay. In vitro cell culture research was conducted by seeding NIH 3T3 fibroblast cells on nanofiber composites, proving these cells’ high cell proliferation rate, viability, and adhesion. 10 wt% GelMA-based nanofiber composites were found to have great potential for wound dressing applications.

© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.Biocomposites are a strong alternative to synthetic fiber-reinforced composites due to their environmentally friendly nature, ease of availability, cost-effectiveness, and non-toxicity. Felt biocomposites are generally favored for their better sound and temperature absorption capabilities rather than load-bearing materials due to their comparatively weak mechanical properties. However, their mechanical performance is greatly improved when they are fabricated as plates using traditional techniques like compression molding. This study focuses on the mechanical characterization and comparison of different types of hot-pressed felt biocomposite plates with a 50% by weight natural fiber content. Four unique biocomposite felts were produced and subjected to tensile, compressive, shear, instrumented Charpy v-notched impact, and drop weight impact tests. All felt kinds are reinforced with short hemp fibers and four distinct polymers are used as matrix materials, namely, polypropylene, recycled polypropylene, polylactic acid, and low-melt polyester fiber. Static and impact tests performed on those materials revealed that each type of natural fiber felt biocomposite has its unique features, and their characterized static and impact behaviors vary significantly from one to another. Therefore, each can be an appropriate material choice in an engineering design. 生物复合材料是合成纤维增强复合材料的有力替代品, 因为其环保性、易 获得性、成本效益和无毒性. 毛毡生物复合材料由于其相对较弱的机械性 能, 通常因其更好的声音和温度吸收能力而非承重材料而受到青睐. 然而, 当它们使用传统技术（如压缩成型）制成板材时, 它们的机械性能会大大 提高. 本研究侧重于具有50重量%天然纤维含量的不同类型热压毡生物复 合材料板的机械特性和比较. 生产了四种独特的生物复合毡, 并进行了拉 伸、压缩、剪切、仪表化夏比v形缺口冲击和落锤冲击试验.所有类型的毛 毡都用短大麻纤维增强, 四种不同的聚合物用作基质材料, 即聚丙烯、再生 聚丙烯、聚乳酸和低熔点聚酯纤维. 对这些材料进行的静态和冲击试验表 明, 每种类型的天然纤维毡生物复合材料都有其独特的特征, 它们的特征静 态和冲击行为各不相同. 因此, 在工程设计中, 每种材料都可以是适当的材 料选择

Natural dyes have grown in popularity due to their eco-friendliness. They can be used as a substitute for synthetic dyes to minimize environmental pollution. This research investigates the natural colouring behaviour of haar singhar flower (HSF) extract in cotton dyeing. Colorant was extracted under various conditions utilizing various extraction mediums such as aqueous, basic, and acidic. On cotton, it was discovered that applying 55 mL of aqueous extract containing 1.5 g/100 mL sodium chloride for 40 minutes at 70 °C yielded the best colour output. A new hue with good colour fastness was developed utilizing chemical and bio-mordants. The existence of nyctanthin as a colouring agent in haar singhar flowers was discovered through FTIR analysis of the extract. The CIE Lab system revealed that using 2 g/100 mL of pistachio shell as a bio-mordant resulted in good quality reddish yellow hues. It was discovered that ultrasonic radiations have a high potential for isolating colourants and dyeing cotton fabric under decreased conditions of temperature, time and volume. The application of biomordants has made the procedure greener, more efficient, and safer.

The use of textiles in soft robotics is gaining popularity because of the advantages textiles offer over other materials in terms of weight, conformability, and ease of manufacture. The purpose of this research is to examine the stitching process used to construct fabric-based pneumatic bending actuators as well as the effect of segment types on the actuators’ properties when used in soft robotic glove applications. To impart bending motion to actuators, two techniques have been used: asymmetry between weave and weft knit fabric layers and mechanical anisotropy between these two textiles. The impacts of various segment types on the actuators’ grip force and bending angle were investigated further. According to experiments, segmenting the actuator with a sewing technique increases the bending angle. It was discovered that actuators with high anisotropy differences in their fabric combinations have high gripping forces. Textile-based capacitive strain sensors are also added to selected segmented actuator types, which possess desirable properties such as increased grip force, increased bending angle, and reduced radial expansion. The sensors were used to demonstrate the controllability of a soft robotic glove using a closed-loop system. Finally, we demonstrated that actuators integrated into a soft wearable glove are capable of grasping a variety of items and performing various grasp types.

Layered double hydroxides (LDHs) offer unique source of inspiration for design of bone mimetic biomaterials due to their superior mechanical properties, drug delivery capability and regulation cellular behaviors, particularly by divalent metal cations in their structure. Three-dimensional (3D) bioprinting of LDHs holds great promise as a novel strategy thanks to highly tunable physiochemical properties and shear-thinning ability of LDHs, which allow shape fidelity after deposition. Herein, we introduce a straightforward strategy for extrusion bioprinting of cell laden nanocomposite hydrogel bioink of gelatin methacryloyl (GelMA) biopolymer and LDHs nanoparticles. First, we synthesized LDHs by co-precipitation process and systematically examined the effect of LDHs addition on printing parameters such as printing pressure, extrusion rate, printing speed, and finally bioink printability in creating grid-like constructs. The developed hydrogel bioinks provided precise control over extrudability, extrusion uniformity, and structural integrity after deposition. Based on the printability and rheological analysis, the printability could be altered by controlling the concentration of LDHs, and printability was found to be ideal with the addition of 3 wt % LDHs. The addition of LDHs resulted in remarkably enhanced compressive strength from 652 kPa (G-LDH0) to 1168 kPa (G-LDH3). It was shown that the printed nanocomposite hydrogel scaffolds were able to support encapsulated osteoblast survival, spreading, and proliferation in the absence of any osteoinductive factors taking advantage of LDHs. In addition, cells encapsulated in G-LDH3 had a larger cell spreading area and higher cell aspect ratio than those encapsulated in G-LDH0. Altogether, the results demonstrated that the developed GelMA/LDHs nanocomposite hydrogel bioink revealed a high potential for extrusion bioprinting with high structural fidelity to fabricate implantable 3D hydrogel constructs for repair of bone defects. WOS:000865405500001 Q2

In this study, 10 mg fluconazole (10 FCZ) and 10 mg gentamicin (10 GEN) loaded with 40% polymethylmethacrylate (40% PMMA) fibers were fabricated by electrospinning and the performance of the formulations (40% PMMA, 40% PMMA/10 FCZ, 40% PMMA/10 GEN, and 40% PMMA/10 FCZ/10 GEN) was tested. 10 mg Gentamicin-loaded 40% PMMA fiber mat showed a more significant zone of inhibition against the S. aureus compared to the zone of 40% PMMA/10 GEN/10 FCZ fiber. The biocompatibility test using a human adipose-derived mesenchymal stem cell (MSCs) as a cell model proved that the amount of loaded and released GEN has no toxic effects on the MSCs.

In the present study, poly(lactic acid) (PLA) and poly(ethylene succinate) (PESu) or poly(ethylene glycol) (PEG) under the framework of quality by design, were blended to produce effective sustained-release matrices for Paclitaxel delivery. A complete physicochemical characterization including weight variation, thickness, water uptake, moisture absorption, moisture loss, and hydrolytic degradation under physiological conditions, was performed. Quality by design approach was applied to study the critical parameters. In vitro cancer toxicity was studied in human cancer cell lines including lung and breast adenocarcinoma. The developed Paclitaxel-loaded films can act as a promising alternative topical matrix as an implant for breast and lung cancer treatment. © 2022 Taylor & Francis Group, LLC. 2-s2.0-85130053009

Addressing osteochondral defects, the objective of current study was to synthesize bilayered hydrogel, where the cartilage layer was formed by alginate (Alg) polyacrylamide (PAAm) with and without the addition of TGF-beta 3 and bone layer by laponite XLS/Alg-PAAm and characterize by in vitro and in vivo experiments. Exceeding the mechanical strength of Alg-PAAm (32.95 +/- 1.23 kPa) and XLS based (317.5 +/- 21.72 kPa) hydrogels, XLS/Alg-PAAm hydrogel (469.7 +/- 6.1 kPa) activated macrophages towards M2 phenotype and stimulated the expression of anti-inflammatory factors. The addition of TGF-beta 3 accelerated transition of macrophage polarization, especially between day 4 and 7. The expression levels of MI-related genes such as CD80, iNOS and TNF-alpha decreased gradually after day 4, reaching lowest values at day 13, whereas the expression levels of M2-related genes, CD206, Argi and SFAT6 significantly increased promoting M2 macrophage polarization, which might be associated with accelerated bone repair. Moreover, bilayer structure exhibited a better cell viability as well as rcpainnent thorough the XIS contents. in vivo histological examinations verified the significant surface regularity and hyaline like tissue formation employment, along with synchronized degradation profile of the hydrogel with tissue healing at the end of 12 weeks. A mechanically durable, biocompatible and immunocompatiblc hydmgcl was formulated to be utilized in bone-cartilage engineering applications., Scientific and Technological Research Council of Turkey (TUBITAK) [117M843, 219M057]; National Research Foundation of Korea [2017K2A9A1A06037807]; Ministry of Science and ICT [NRF-2018M3A7B4089670]; TUBITAK 2211-A National Graduate Scholarship Program; TUBITAK [2211-A], This work was supported by The Scientific and Technological Research Council of Turkey (TUBITAK) under grant number 117M843 and immune response studies under grant 219M057. Y.-W.Kim and J.-Y.Sun were sup-ported under the framework of international cooperation program managed by the National Research Foundation of Korea (2017K2A9A1A06037807, FY2017) . Authors would like to acknowledge Material Technology Develop-ment Program through the National Research Foundation of Korea (NRF) funded by Ministry of Science and ICT (NRF-2018M3A7B4089670) . E.S and P.S.M gratefully acknowledge the TUBITAK 2211-A National Graduate Scholarship Program.