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1. Comparison of Patient Health Questionnaire-9, Edinburgh Postnatal Depression Scale and Hospital Anxiety and Depression – Depression subscale scores by administration mode: An individual participant data differential item functioning meta-analysis

Author

Azar, Marleine, Bhandari, Parash Mani, Chiovitti, Matthew J., He, Chen, Imran, Mahrukh, Krishnan, Ankur, Negeri, Zelalem, Neupane, Dipika, Riehm, Kira E., Yan, Xin Wei, Kloda, Lorie A., Henry, Melissa, Ismail, Zahinoor, Loiselle, Carmen G., Mitchell, Nicholas D., Al-Adawi, Samir, Alvarado, Rubén, Amtmann, Dagmar, Arroll, Bruce, Ayalon, Liat, Baradaran, Hamid R., Barnes, Jacqueline, Beck, Kevin R., Beck, Cheryl Tatano, Bernstein, Charles N., Bindt, Carola, Bombardier, Charles H., Boye, Birgitte, Büel-Drabe, Natalie, Buji, Ryna Imma, Bunevicius, Adomas, Butterworth, Peter, Can, Ceyhun, Carter, Gregory, Chagas, Marcos H., Chan, Juliana C.N., Chan, Lai Fong, Chen, Chih-Ken, Chibanda, Dixon, Chorwe-Sungani, Genesis, Clover, Kerrie, Conroy, Ronán M., Conway, Aaron, Conwell, Yeates, Correa, Humberto, Couto, Thiago Castro e, Cukor, Daniel, Daray, Federico M., de Man-van Ginkel, Janneke M., De Souza, Jennifer, Downing, Marina G., Eapen, Valsamma, Fann, Jesse R., Favez, Nicolas, Felice, Ethel, Fellmeth, Gracia, Ferentinos, Panagiotis P., Fernandes, Michelle, Field, Sally, Figueiredo, Barbara, Fischer, Felix H., Fisher, Jane R.W., Flint, Alastair J., Fujimori, Maiko, Fung, Daniel S.S., Gallagher, Pamela, Gandy, Milena, Gelaye, Bizu, Gholizadeh, Leila, Gibson, Lorna J., Goodyear-Smith, Felicity, Grassi, Luigi, Green, Eric P., Greeno, Catherine G., Hall, Brian J., Hantsoo, Liisa, Haroz, Emily E., Härter, Martin, Hegerl, Ulrich, Helle, Nadine, Hernando, Asuncion, Hides, Leanne, Hobfoll, Stevan E., Honikman, Simone, Howard, Louise M., Hyphantis, Thomas, Iglesias-González, Maria, Inagaki, Masatoshi, Jenewein, Josef, Jeon, Hong Jin, Jetté, Nathalie, Julião, Miguel, Kettunen, Pirjo A., Khamseh, Mohammad E., Kiely, Kim M., Kim, Sung-Wan, Kjærgaard, Marie, Kohlhoff, Jane, Kohrt, Brandon A., König, Hans-Helmut, Kozinszky, Zoltán, Kwan, Yunxin, Lamers, Femke, Lara, María Asunción, Leonardou, Angeliki A., Levin-Aspenson, Holly F., Liu, Shen-Ing, Löbner, Margrit, Loosman, Wim L., Lotrakul, Manote, Loureiro, Sonia R., Love, Anthony W., Löwe, Bernd, Luitel, Nagendra P., Lund, Crick, Maes, Michael, Malt, Ulrik F., Marrie, Ruth Ann, Marsh, Laura, Martínez, Pablo, Marx, Brian P., Matsuoka, Yutaka, McGuire, Anthony, Mehnert, Anja, Michopoulos, Ioannis, Sidik, Sherina Mohd, Müller-Nordhorn, Jacqueline, Muramatsu, Kumiko, Radoš, Sandra Nakić, Navarrete, Laura, Nelson, Christian J., Ng, Chong Guan, Nishi, Daisuke, O'Donnell, Meaghan L., O'Rourke, Suzanne J., Osório, Flávia L., Pabst, Alexander, Pasco, Julie A., Pawlby, Susan J., Peceliuniene, Jurate, Pence, Brian W., Persoons, Philippe, Petersen, Inge, Picardi, Angelo, Ponsford, Jennie L., Pugh, Stephanie L., Pulido, Federico, Quinn, Terence J., Quispel, Chantal, Rathod, Sujit D., Reme, Silje E., Reuter, Katrin, Riedel-Heller, Steffi G., Rooney, Alasdair G., Santos, Iná S., Saracino, Rebecca M., Schellekens, Melanie P.J., Schwarzbold, Marcelo L., Cankorur, Vesile Senturk, Shaaban, Juwita, Sharp, Deborah J., Sharpe, Louise, Shinn, Eileen H., Sidebottom, Abbey, Simard, Sébastien, Singer, Susanne, Skalkidou, Alkistis, Smith-Nielsen, Johanne, Spangenberg, Lena, Stafford, Lesley, Stein, Alan, Stewart, Robert C., Strobel, Natalie A., Su, Kuan-Pin, Sultan, Serge, Sundström-Poromaa, Inger, Sung, Sharon C., Suzuki, Keiko, Tadinac, Meri, Tan, Pei Lin Lynnette, Tandon, S. Darius, Taylor-Rowan, Martin, Teixeira, Antonio L., Tendais, Iva, Tiringer, Istvan, Töreki, Annamária, Tran, Thach D., Trevillion, Kylee, Tschorn, Mira, Turner, Alyna, Væver, Mette S., van der Feltz-Cornelis, Christina M., van Heyningen, Thandi, Vega-Dienstmaier, Johann M., Wagner, Michael, Wagner, Lynne I., Wang, Liang-Jen, Wang, Jian Li, Watson, David, Weyerer, Siegfried B., White, Jennifer, Whooley, Mary A., Wiese, Birgitt, Williams, Lana J., Winkley, Kirsty, Wynter, Karen, Yamada, Mitsuhiko, Yonkers, Kimberly A., Zeng, Qing Zhi, Zhang, Yuying, Harel, Daphna, Wu, Yin, Levis, Brooke, Fan, Suiqiong, Sun, Ying, Xu, Mingyao, Rice, Danielle B., Boruff, Jill, Markham, Sarah, Ioannidis, John P.A., Takwoingi, Yemisi, Patten, Scott B., Ziegelstein, Roy C., Cuijpers, Pim, Gilbody, Simon, Vigod, Simone, Akena, Dickens, Benedetti, Andrea, and Thombs, Brett D.

Published
2024
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2. In vivo hippocampal subfield volumes in bipolar disorder—A mega‐analysis from The Enhancing Neuro Imaging Genetics through Meta‐Analysis Bipolar Disorder Working Group

Author

Haukvik, Unn K, Gurholt, Tiril P, Nerland, Stener, Elvsåshagen, Torbjørn, Akudjedu, Theophilus N, Alda, Martin, Alnæs, Dag, Alonso‐Lana, Silvia, Bauer, Jochen, Baune, Bernhard T, Benedetti, Francesco, Berk, Michael, Bettella, Francesco, Bøen, Erlend, Bonnín, Caterina M, Brambilla, Paolo, Canales‐Rodríguez, Erick J, Cannon, Dara M, Caseras, Xavier, Dandash, Orwa, Dannlowski, Udo, Delvecchio, Giuseppe, Díaz‐Zuluaga, Ana M, Erp, Theo GM, Fatjó‐Vilas, Mar, Foley, Sonya F, Förster, Katharina, Fullerton, Janice M, Goikolea, José M, Grotegerd, Dominik, Gruber, Oliver, Haarman, Bartholomeus CM, Haatveit, Beathe, Hajek, Tomas, Hallahan, Brian, Harris, Mathew, Hawkins, Emma L, Howells, Fleur M, Hülsmann, Carina, Jahanshad, Neda, Jørgensen, Kjetil N, Kircher, Tilo, Krämer, Bernd, Krug, Axel, Kuplicki, Rayus, Lagerberg, Trine V, Lancaster, Thomas M, Lenroot, Rhoshel K, Lonning, Vera, López‐Jaramillo, Carlos, Malt, Ulrik F, McDonald, Colm, McIntosh, Andrew M, McPhilemy, Genevieve, Meer, Dennis, Melle, Ingrid, Melloni, Elisa MT, Mitchell, Philip B, Nabulsi, Leila, Nenadić, Igor, Oertel, Viola, Oldani, Lucio, Opel, Nils, Otaduy, Maria CG, Overs, Bronwyn J, Pineda‐Zapata, Julian A, Pomarol‐Clotet, Edith, Radua, Joaquim, Rauer, Lisa, Redlich, Ronny, Repple, Jonathan, Rive, Maria M, Roberts, Gloria, Ruhe, Henricus G, Salminen, Lauren E, Salvador, Raymond, Sarró, Salvador, Savitz, Jonathan, Schene, Aart H, Sim, Kang, Soeiro‐de‐Souza, Marcio G, Stäblein, Michael, Stein, Dan J, Stein, Frederike, Tamnes, Christian K, Temmingh, Henk S, Thomopoulos, Sophia I, Veltman, Dick J, Vieta, Eduard, Waltemate, Lena, Westlye, Lars T, Whalley, Heather C, Sämann, Philipp G, Thompson, Paul M, Ching, Christopher RK, Andreassen, Ole A, Agartz, Ingrid, and Group, ENIGMA Bipolar Disorder Working

Subjects
Biological Psychology, Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Psychology, Brain Disorders, Mental Health, Serious Mental Illness, Neurosciences, Biomedical Imaging, Bipolar Disorder, Mental health, Genetics, Hippocampus, Humans, Magnetic Resonance Imaging, Neuroimaging, ENIGMA Bipolar Disorder Working Group, bipolar disorder subtype, hippocampus, large-scale, lithium, psychosis, structural brain MRI, Cognitive Sciences, Experimental Psychology, Biological psychology, Cognitive and computational psychology
Abstract

The hippocampus consists of anatomically and functionally distinct subfields that may be differentially involved in the pathophysiology of bipolar disorder (BD). Here we, the Enhancing NeuroImaging Genetics through Meta-Analysis Bipolar Disorder workinggroup, study hippocampal subfield volumetry in BD. T1-weighted magnetic resonance imaging scans from 4,698 individuals (BD = 1,472, healthy controls [HC] = 3,226) from 23 sites worldwide were processed with FreeSurfer. We used linear mixed-effects models and mega-analysis to investigate differences in hippocampal subfield volumes between BD and HC, followed by analyses of clinical characteristics and medication use. BD showed significantly smaller volumes of the whole hippocampus (Cohen's d = -0.20), cornu ammonis (CA)1 (d = -0.18), CA2/3 (d = -0.11), CA4 (d = -0.19), molecular layer (d = -0.21), granule cell layer of dentate gyrus (d = -0.21), hippocampal tail (d = -0.10), subiculum (d = -0.15), presubiculum (d = -0.18), and hippocampal amygdala transition area (d = -0.17) compared to HC. Lithium users did not show volume differences compared to HC, while non-users did. Antipsychotics or antiepileptic use was associated with smaller volumes. In this largest study of hippocampal subfields in BD to date, we show widespread reductions in nine of 12 subfields studied. The associations were modulated by medication use and specifically the lack of differences between lithium users and HC supports a possible protective role of lithium in BD.

Published
2022

3. Association between body mass index and subcortical brain volumes in bipolar disorders–ENIGMA study in 2735 individuals

Author

McWhinney, Sean R, Abé, Christoph, Alda, Martin, Benedetti, Francesco, Bøen, Erlend, del Mar Bonnin, Caterina, Borgers, Tiana, Brosch, Katharina, Canales-Rodríguez, Erick J, Cannon, Dara M, Dannlowski, Udo, Díaz-Zuluaga, Ana M, Elvsåshagen, Torbjørn, Eyler, Lisa T, Fullerton, Janice M, Goikolea, Jose M, Goltermann, Janik, Grotegerd, Dominik, Haarman, Bartholomeus CM, Hahn, Tim, Howells, Fleur M, Ingvar, Martin, Kircher, Tilo TJ, Krug, Axel, Kuplicki, Rayus T, Landén, Mikael, Lemke, Hannah, Liberg, Benny, Lopez-Jaramillo, Carlos, Malt, Ulrik F, Martyn, Fiona M, Mazza, Elena, McDonald, Colm, McPhilemy, Genevieve, Meier, Sandra, Meinert, Susanne, Meller, Tina, Melloni, Elisa MT, Mitchell, Philip B, Nabulsi, Leila, Nenadic, Igor, Opel, Nils, Ophoff, Roel A, Overs, Bronwyn J, Pfarr, Julia-Katharina, Pineda-Zapata, Julian A, Pomarol-Clotet, Edith, Raduà, Joaquim, Repple, Jonathan, Richter, Maike, Ringwald, Kai G, Roberts, Gloria, Salvador, Raymond, Savitz, Jonathan, Schmitt, Simon, Schofield, Peter R, Sim, Kang, Stein, Dan J, Stein, Frederike, Temmingh, Henk S, Thiel, Katharina, van Haren, Neeltje EM, Gestel, Holly Van, Vargas, Cristian, Vieta, Eduard, Vreeker, Annabel, Waltemate, Lena, Yatham, Lakshmi N, Ching, Christopher RK, Andreassen, Ole, Thompson, Paul M, and Hajek, Tomas

Subjects
Biological Psychology, Biomedical and Clinical Sciences, Psychology, Mental Health, Biomedical Imaging, Nutrition, Brain Disorders, Obesity, Neurosciences, Clinical Research, Prevention, Mental health, Amygdala, Bipolar Disorder, Body Mass Index, Brain, Humans, Magnetic Resonance Imaging, ENIGMA Bipolar Disorders Working Group, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Clinical sciences, Biological psychology, Clinical and health psychology
Abstract

Individuals with bipolar disorders (BD) frequently suffer from obesity, which is often associated with neurostructural alterations. Yet, the effects of obesity on brain structure in BD are under-researched. We obtained MRI-derived brain subcortical volumes and body mass index (BMI) from 1134 BD and 1601 control individuals from 17 independent research sites within the ENIGMA-BD Working Group. We jointly modeled the effects of BD and BMI on subcortical volumes using mixed-effects modeling and tested for mediation of group differences by obesity using nonparametric bootstrapping. All models controlled for age, sex, hemisphere, total intracranial volume, and data collection site. Relative to controls, individuals with BD had significantly higher BMI, larger lateral ventricular volume, and smaller volumes of amygdala, hippocampus, pallidum, caudate, and thalamus. BMI was positively associated with ventricular and amygdala and negatively with pallidal volumes. When analyzed jointly, both BD and BMI remained associated with volumes of lateral ventricles  and amygdala. Adjusting for BMI decreased the BD vs control differences in ventricular volume. Specifically, 18.41% of the association between BD and ventricular volume was mediated by BMI (Z = 2.73, p = 0.006). BMI was associated with similar regional brain volumes as BD, including lateral ventricles, amygdala, and pallidum. Higher BMI may in part account for larger ventricles, one of the most replicated findings in BD. Comorbidity with obesity could explain why neurostructural alterations are more pronounced in some individuals with BD. Future prospective brain imaging studies should investigate whether obesity could be a modifiable risk factor for neuroprogression.

Published
2021

4. Using structural MRI to identify bipolar disorders – 13 site machine learning study in 3020 individuals from the ENIGMA Bipolar Disorders Working Group

Author

Nunes, Abraham, Schnack, Hugo G, Ching, Christopher RK, Agartz, Ingrid, Akudjedu, Theophilus N, Alda, Martin, Alnæs, Dag, Alonso-Lana, Silvia, Bauer, Jochen, Baune, Bernhard T, Bøen, Erlend, Bonnin, Caterina del Mar, Busatto, Geraldo F, Canales-Rodríguez, Erick J, Cannon, Dara M, Caseras, Xavier, Chaim-Avancini, Tiffany M, Dannlowski, Udo, Díaz-Zuluaga, Ana M, Dietsche, Bruno, Doan, Nhat Trung, Duchesnay, Edouard, Elvsåshagen, Torbjørn, Emden, Daniel, Eyler, Lisa T, Fatjó-Vilas, Mar, Favre, Pauline, Foley, Sonya F, Fullerton, Janice M, Glahn, David C, Goikolea, Jose M, Grotegerd, Dominik, Hahn, Tim, Henry, Chantal, Hibar, Derrek P, Houenou, Josselin, Howells, Fleur M, Jahanshad, Neda, Kaufmann, Tobias, Kenney, Joanne, Kircher, Tilo TJ, Krug, Axel, Lagerberg, Trine V, Lenroot, Rhoshel K, López-Jaramillo, Carlos, Machado-Vieira, Rodrigo, Malt, Ulrik F, McDonald, Colm, Mitchell, Philip B, Mwangi, Benson, Nabulsi, Leila, Opel, Nils, Overs, Bronwyn J, Pineda-Zapata, Julian A, Pomarol-Clotet, Edith, Redlich, Ronny, Roberts, Gloria, Rosa, Pedro G, Salvador, Raymond, Satterthwaite, Theodore D, Soares, Jair C, Stein, Dan J, Temmingh, Henk S, Trappenberg, Thomas, Uhlmann, Anne, van Haren, Neeltje EM, Vieta, Eduard, Westlye, Lars T, Wolf, Daniel H, Yüksel, Dilara, Zanetti, Marcus V, Andreassen, Ole A, Thompson, Paul M, and Hajek, Tomas

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Brain Disorders, Biomedical Imaging, Neurosciences, Mental Health, Clinical Research, Mental health, Bipolar Disorder, Brain, Humans, Machine Learning, Magnetic Resonance Imaging, Neuroimaging, ENIGMA Bipolar Disorders Working Group, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Clinical sciences, Biological psychology, Clinical and health psychology
Abstract

Bipolar disorders (BDs) are among the leading causes of morbidity and disability. Objective biological markers, such as those based on brain imaging, could aid in clinical management of BD. Machine learning (ML) brings neuroimaging analyses to individual subject level and may potentially allow for their diagnostic use. However, fair and optimal application of ML requires large, multi-site datasets. We applied ML (support vector machines) to MRI data (regional cortical thickness, surface area, subcortical volumes) from 853 BD and 2167 control participants from 13 cohorts in the ENIGMA consortium. We attempted to differentiate BD from control participants, investigated different data handling strategies and studied the neuroimaging/clinical features most important for classification. Individual site accuracies ranged from 45.23% to 81.07%. Aggregate subject-level analyses yielded the highest accuracy (65.23%, 95% CI = 63.47-67.00, ROC-AUC = 71.49%, 95% CI = 69.39-73.59), followed by leave-one-site-out cross-validation (accuracy = 58.67%, 95% CI = 56.70-60.63). Meta-analysis of individual site accuracies did not provide above chance results. There was substantial agreement between the regions that contributed to identification of BD participants in the best performing site and in the aggregate dataset (Cohen's Kappa = 0.83, 95% CI = 0.829-0.831). Treatment with anticonvulsants and age were associated with greater odds of correct classification. Although short of the 80% clinically relevant accuracy threshold, the results are promising and provide a fair and realistic estimate of classification performance, which can be achieved in a large, ecologically valid, multi-site sample of BD participants based on regional neurostructural measures. Furthermore, the significant classification in different samples was based on plausible and similar neuroanatomical features. Future multi-site studies should move towards sharing of raw/voxelwise neuroimaging data.

Published
2020

5. Common brain disorders are associated with heritable patterns of apparent aging of the brain

Author

Kaufmann, Tobias, van der Meer, Dennis, Doan, Nhat Trung, Schwarz, Emanuel, Lund, Martina J, Agartz, Ingrid, Alnæs, Dag, Barch, Deanna M, Baur-Streubel, Ramona, Bertolino, Alessandro, Bettella, Francesco, Beyer, Mona K, Bøen, Erlend, Borgwardt, Stefan, Brandt, Christine L, Buitelaar, Jan, Celius, Elisabeth G, Cervenka, Simon, Conzelmann, Annette, Córdova-Palomera, Aldo, Dale, Anders M, de Quervain, Dominique JF, Di Carlo, Pasquale, Djurovic, Srdjan, Dørum, Erlend S, Eisenacher, Sarah, Elvsåshagen, Torbjørn, Espeseth, Thomas, Fatouros-Bergman, Helena, Flyckt, Lena, Franke, Barbara, Frei, Oleksandr, Haatveit, Beathe, Håberg, Asta K, Harbo, Hanne F, Hartman, Catharina A, Heslenfeld, Dirk, Hoekstra, Pieter J, Høgestøl, Einar A, Jernigan, Terry L, Jonassen, Rune, Jönsson, Erik G, Kirsch, Peter, Kłoszewska, Iwona, Kolskår, Knut K, Landrø, Nils Inge, Le Hellard, Stephanie, Lesch, Klaus-Peter, Lovestone, Simon, Lundervold, Arvid, Lundervold, Astri J, Maglanoc, Luigi A, Malt, Ulrik F, Mecocci, Patrizia, Melle, Ingrid, Meyer-Lindenberg, Andreas, Moberget, Torgeir, Norbom, Linn B, Nordvik, Jan Egil, Nyberg, Lars, Oosterlaan, Jaap, Papalino, Marco, Papassotiropoulos, Andreas, Pauli, Paul, Pergola, Giulio, Persson, Karin, Richard, Geneviève, Rokicki, Jaroslav, Sanders, Anne-Marthe, Selbæk, Geir, Shadrin, Alexey A, Smeland, Olav B, Soininen, Hilkka, Sowa, Piotr, Steen, Vidar M, Tsolaki, Magda, Ulrichsen, Kristine M, Vellas, Bruno, Wang, Lei, Westman, Eric, Ziegler, Georg C, Zink, Mathias, Andreassen, Ole A, and Westlye, Lars T

Subjects
Biological Psychology, Psychology, Rare Diseases, Mental Health, Neurosciences, Brain Disorders, Biomedical Imaging, Aging, Aetiology, 2.3 Psychological, social and economic factors, 1.1 Normal biological development and functioning, Underpinning research, Mental health, Neurological, Adolescent, Adult, Aged, Aged, 80 and over, Algorithms, Brain, Brain Diseases, Child, Child, Preschool, Female, Genome-Wide Association Study, Humans, Infant, Magnetic Resonance Imaging, Male, Mental Disorders, Middle Aged, Neuropsychological Tests, Schizophrenia, Sex Characteristics, Young Adult, Karolinska Schizophrenia Project, Cognitive Sciences, Neurology & Neurosurgery, Biological psychology
Abstract

Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.

Published
2019

6. Genetic variants associated with longitudinal changes in brain structure across the lifespan

Author

Brouwer, Rachel M., Klein, Marieke, Grasby, Katrina L., Schnack, Hugo G., Jahanshad, Neda, Teeuw, Jalmar, Thomopoulos, Sophia I., Sprooten, Emma, Franz, Carol E., Gogtay, Nitin, Kremen, William S., Panizzon, Matthew S., Olde Loohuis, Loes M., Whelan, Christopher D., Aghajani, Moji, Alloza, Clara, Alnæs, Dag, Artiges, Eric, Ayesa-Arriola, Rosa, Barker, Gareth J., Bastin, Mark E., Blok, Elisabet, Bøen, Erlend, Breukelaar, Isabella A., Bright, Joanna K., Buimer, Elizabeth E. L., Bülow, Robin, Cannon, Dara M., Ciufolini, Simone, Crossley, Nicolas A., Damatac, Christienne G., Dazzan, Paola, de Mol, Casper L., de Zwarte, Sonja M. C., Desrivières, Sylvane, Díaz-Caneja, Covadonga M., Doan, Nhat Trung, Dohm, Katharina, Fröhner, Juliane H., Goltermann, Janik, Grigis, Antoine, Grotegerd, Dominik, Han, Laura K. M., Harris, Mathew A., Hartman, Catharina A., Heany, Sarah J., Heindel, Walter, Heslenfeld, Dirk J., Hohmann, Sarah, Ittermann, Bernd, Jansen, Philip R., Janssen, Joost, Jia, Tianye, Jiang, Jiyang, Jockwitz, Christiane, Karali, Temmuz, Keeser, Daniel, Koevoets, Martijn G. J. C., Lenroot, Rhoshel K., Malchow, Berend, Mandl, René C. W., Medel, Vicente, Meinert, Susanne, Morgan, Catherine A., Mühleisen, Thomas W., Nabulsi, Leila, Opel, Nils, de la Foz, Víctor Ortiz-García, Overs, Bronwyn J., Paillère Martinot, Marie-Laure, Redlich, Ronny, Marques, Tiago Reis, Repple, Jonathan, Roberts, Gloria, Roshchupkin, Gennady V., Setiaman, Nikita, Shumskaya, Elena, Stein, Frederike, Sudre, Gustavo, Takahashi, Shun, Thalamuthu, Anbupalam, Tordesillas-Gutiérrez, Diana, van der Lugt, Aad, van Haren, Neeltje E. M., Wardlaw, Joanna M., Wen, Wei, Westeneng, Henk-Jan, Wittfeld, Katharina, Zhu, Alyssa H., Zugman, Andre, Armstrong, Nicola J., Bonfiglio, Gaia, Bralten, Janita, Dalvie, Shareefa, Davies, Gail, Di Forti, Marta, Ding, Linda, Donohoe, Gary, Forstner, Andreas J., Gonzalez-Peñas, Javier, Guimaraes, Joao P. O. F. T., Homuth, Georg, Hottenga, Jouke-Jan, Knol, Maria J., Kwok, John B. J., Le Hellard, Stephanie, Mather, Karen A., Milaneschi, Yuri, Morris, Derek W., Nöthen, Markus M., Papiol, Sergi, Rietschel, Marcella, Santoro, Marcos L., Steen, Vidar M., Stein, Jason L., Streit, Fabian, Tankard, Rick M., Teumer, Alexander, van ‘t Ent, Dennis, van der Meer, Dennis, van Eijk, Kristel R., Vassos, Evangelos, Vázquez-Bourgon, Javier, Witt, Stephanie H., Adams, Hieab H. H., Agartz, Ingrid, Ames, David, Amunts, Katrin, Andreassen, Ole A., Arango, Celso, Banaschewski, Tobias, Baune, Bernhard T., Belangero, Sintia I., Bokde, Arun L. W., Boomsma, Dorret I., Bressan, Rodrigo A., Brodaty, Henry, Buitelaar, Jan K., Cahn, Wiepke, Caspers, Svenja, Cichon, Sven, Crespo-Facorro, Benedicto, Cox, Simon R., Dannlowski, Udo, Elvsåshagen, Torbjørn, Espeseth, Thomas, Falkai, Peter G., Fisher, Simon E., Flor, Herta, Fullerton, Janice M., Garavan, Hugh, Gowland, Penny A., Grabe, Hans J., Hahn, Tim, Heinz, Andreas, Hillegers, Manon, Hoare, Jacqueline, Hoekstra, Pieter J., Ikram, Mohammad A., Jackowski, Andrea P., Jansen, Andreas, Jönsson, Erik G., Kahn, Rene S., Kircher, Tilo, Korgaonkar, Mayuresh S., Krug, Axel, Lemaitre, Herve, Malt, Ulrik F., Martinot, Jean-Luc, McDonald, Colm, Mitchell, Philip B., Muetzel, Ryan L., Murray, Robin M., Nees, Frauke, Nenadić, Igor, Oosterlaan, Jaap, Ophoff, Roel A., Pan, Pedro M., Penninx, Brenda W. J. H., Poustka, Luise, Sachdev, Perminder S., Salum, Giovanni A., Schofield, Peter R., Schumann, Gunter, Shaw, Philip, Sim, Kang, Smolka, Michael N., Stein, Dan J., Trollor, Julian N., van den Berg, Leonard H., Veldink, Jan H., Walter, Henrik, Westlye, Lars T., Whelan, Robert, White, Tonya, Wright, Margaret J., Medland, Sarah E., Franke, Barbara, Thompson, Paul M., and Hulshoff Pol, Hilleke E.

Published
2022
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8. Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group

Author

Han, Laura K. M., Dinga, Richard, Hahn, Tim, Ching, Christopher R. K., Eyler, Lisa T., Aftanas, Lyubomir, Aghajani, Moji, Aleman, André, Baune, Bernhard T., Berger, Klaus, Brak, Ivan, Filho, Geraldo Busatto, Carballedo, Angela, Connolly, Colm G., Couvy-Duchesne, Baptiste, Cullen, Kathryn R., Dannlowski, Udo, Davey, Christopher G., Dima, Danai, Duran, Fabio L. S., Enneking, Verena, Filimonova, Elena, Frenzel, Stefan, Frodl, Thomas, Fu, Cynthia H. Y., Godlewska, Beata R., Gotlib, Ian H., Grabe, Hans J., Groenewold, Nynke A., Grotegerd, Dominik, Gruber, Oliver, Hall, Geoffrey B., Harrison, Ben J., Hatton, Sean N., Hermesdorf, Marco, Hickie, Ian B., Ho, Tiffany C., Hosten, Norbert, Jansen, Andreas, Kähler, Claas, Kircher, Tilo, Klimes-Dougan, Bonnie, Krämer, Bernd, Krug, Axel, Lagopoulos, Jim, Leenings, Ramona, MacMaster, Frank P., MacQueen, Glenda, McIntosh, Andrew, McLellan, Quinn, McMahon, Katie L., Medland, Sarah E., Mueller, Bryon A., Mwangi, Benson, Osipov, Evgeny, Portella, Maria J., Pozzi, Elena, Reneman, Liesbeth, Repple, Jonathan, Rosa, Pedro G. P., Sacchet, Matthew D., Sämann, Philipp G., Schnell, Knut, Schrantee, Anouk, Simulionyte, Egle, Soares, Jair C., Sommer, Jens, Stein, Dan J., Steinsträter, Olaf, Strike, Lachlan T., Thomopoulos, Sophia I., van Tol, Marie-José, Veer, Ilya M., Vermeiren, Robert R. J. M., Walter, Henrik, van der Wee, Nic J. A., van der Werff, Steven J. A., Whalley, Heather, Winter, Nils R., Wittfeld, Katharina, Wright, Margaret J., Wu, Mon-Ju, Völzke, Henry, Yang, Tony T., Zannias, Vasileios, de Zubicaray, Greig I., Zunta-Soares, Giovana B., Abé, Christoph, Alda, Martin, Andreassen, Ole A., Bøen, Erlend, Bonnin, Caterina M., Canales-Rodriguez, Erick J., Cannon, Dara, Caseras, Xavier, Chaim-Avancini, Tiffany M., Elvsåshagen, Torbjørn, Favre, Pauline, Foley, Sonya F., Fullerton, Janice M., Goikolea, Jose M., Haarman, Bartholomeus C. M., Hajek, Tomas, Henry, Chantal, Houenou, Josselin, Howells, Fleur M., Ingvar, Martin, Kuplicki, Rayus, Lafer, Beny, Landén, Mikael, Machado-Vieira, Rodrigo, Malt, Ulrik F., McDonald, Colm, Mitchell, Philip B., Nabulsi, Leila, Otaduy, Maria Concepcion Garcia, Overs, Bronwyn J., Polosan, Mircea, Pomarol-Clotet, Edith, Radua, Joaquim, Rive, Maria M., Roberts, Gloria, Ruhe, Henricus G., Salvador, Raymond, Sarró, Salvador, Satterthwaite, Theodore D., Savitz, Jonathan, Schene, Aart H., Schofield, Peter R., Serpa, Mauricio H., Sim, Kang, Soeiro-de-Souza, Marcio Gerhardt, Sutherland, Ashley N., Temmingh, Henk S., Timmons, Garrett M., Uhlmann, Anne, Vieta, Eduard, Wolf, Daniel H., Zanetti, Marcus V., Jahanshad, Neda, Thompson, Paul M., Veltman, Dick J., Penninx, Brenda W. J. H., Marquand, Andre F., Cole, James H., and Schmaal, Lianne

Published
2021
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11. Baseline long‐term potentiation‐like cortical plasticity is associated with longitudinal cortical thinning in healthy adults and in adults with bipolar disorder type II

Author

Zak, Nathalia, primary, Moberget, Torgeir, additional, Bøen, Erlend, additional, Boye, Birgitte, additional, Rygvold, Trine W., additional, Malt, Ulrik F., additional, Andreassen, Ole A., additional, Andersson, Stein, additional, Westlye, Lars T., additional, and Elvsåshagen, Torbjørn, additional

Published
2023
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12. Mega-analysis of association between obesity and cortical morphology in bipolar disorders:ENIGMA study in 2832 participants

Author

Mcwhinney, Sean R., Abé, Christoph, Alda, Martin, Benedetti, Francesco, Boen, Erlend, Del Mar Bonnin, Caterina, Borgers, Tiana, Brosch, Katharina, Canales-Rodríguez, Erick J., Cannon, Dara M., Dannlowski, Udo, Diaz-Zuluaga, Ana M., Dietze, Lorielle M.F., Elvsåshagen, Torbjorn, Eyler, Lisa T., Fullerton, Janice M., Goikolea, Jose M., Goltermann, Janik, Grotegerd, Dominik, Haarman, Bartholomeus C.M., Hahn, Tim, Howells, Fleur M., Ingvar, Martin, Jahanshad, Neda, Kircher, Tilo T.J., Krug, Axel, Kuplicki, Rayus T., Landén, Mikael, Lemke, Hannah, Liberg, Benny, Lopez-Jaramillo, Carlos, Malt, Ulrik F., Martyn, Fiona M., Mazza, Elena, Mcdonald, Colm, Mcphilemy, Genevieve, Meier, Sandra, Meinert, Susanne, Meller, Tina, Melloni, Elisa M.T., Mitchell, Philip B., Nabulsi, Leila, Nenadic, Igor, Opel, Nils, Ophoff, Roel A., Overs, Bronwyn J., Pfarr, Julia Katharina, Pineda-Zapata, Julian A., Pomarol-Clotet, Edith, Raduà, Joaquim, Repple, Jonathan, Richter, Maike, Ringwald, Kai G., Roberts, Gloria, Ross, Alex, Salvador, Raymond, Savitz, Jonathan, Schmitt, Simon, Schofield, Peter R., Sim, Kang, Stein, Dan J., Stein, Frederike, Temmingh, Henk S., Thiel, Katharina, Thomopoulos, Sophia I., Van Haren, Neeltje E.M., Vargas, Cristian, Vieta, Eduard, Vreeker, Annabel, Waltemate, Lena, Yatham, Lakshmi N., Ching, Christopher R.K., Andreassen, Ole A., Thompson, Paul M., Hajek, Tomas, Mcwhinney, Sean R., Abé, Christoph, Alda, Martin, Benedetti, Francesco, Boen, Erlend, Del Mar Bonnin, Caterina, Borgers, Tiana, Brosch, Katharina, Canales-Rodríguez, Erick J., Cannon, Dara M., Dannlowski, Udo, Diaz-Zuluaga, Ana M., Dietze, Lorielle M.F., Elvsåshagen, Torbjorn, Eyler, Lisa T., Fullerton, Janice M., Goikolea, Jose M., Goltermann, Janik, Grotegerd, Dominik, Haarman, Bartholomeus C.M., Hahn, Tim, Howells, Fleur M., Ingvar, Martin, Jahanshad, Neda, Kircher, Tilo T.J., Krug, Axel, Kuplicki, Rayus T., Landén, Mikael, Lemke, Hannah, Liberg, Benny, Lopez-Jaramillo, Carlos, Malt, Ulrik F., Martyn, Fiona M., Mazza, Elena, Mcdonald, Colm, Mcphilemy, Genevieve, Meier, Sandra, Meinert, Susanne, Meller, Tina, Melloni, Elisa M.T., Mitchell, Philip B., Nabulsi, Leila, Nenadic, Igor, Opel, Nils, Ophoff, Roel A., Overs, Bronwyn J., Pfarr, Julia Katharina, Pineda-Zapata, Julian A., Pomarol-Clotet, Edith, Raduà, Joaquim, Repple, Jonathan, Richter, Maike, Ringwald, Kai G., Roberts, Gloria, Ross, Alex, Salvador, Raymond, Savitz, Jonathan, Schmitt, Simon, Schofield, Peter R., Sim, Kang, Stein, Dan J., Stein, Frederike, Temmingh, Henk S., Thiel, Katharina, Thomopoulos, Sophia I., Van Haren, Neeltje E.M., Vargas, Cristian, Vieta, Eduard, Vreeker, Annabel, Waltemate, Lena, Yatham, Lakshmi N., Ching, Christopher R.K., Andreassen, Ole A., Thompson, Paul M., and Hajek, Tomas

Abstract

Background: Obesity is highly prevalent and disabling, especially in individuals with severe mental illness including bipolar disorders (BD). The brain is a target organ for both obesity and BD. Yet, we do not understand how cortical brain alterations in BD and obesity interact. Methods: We obtained body mass index (BMI) and MRI-derived regional cortical thickness, surface area from 1231 BD and 1601 control individuals from 13 countries within the ENIGMA-BD Working Group. We jointly modeled the statistical effects of BD and BMI on brain structure using mixed effects and tested for interaction and mediation. We also investigated the impact of medications on the BMI-related associations. Results: BMI and BD additively impacted the structure of many of the same brain regions. Both BMI and BD were negatively associated with cortical thickness, but not surface area. In most regions the number of jointly used psychiatric medication classes remained associated with lower cortical thickness when controlling for BMI. In a single region, fusiform gyrus, about a third of the negative association between number of jointly used psychiatric medications and cortical thickness was mediated by association between the number of medications and higher BMI. Conclusions: We confirmed consistent associations between higher BMI and lower cortical thickness, but not surface area, across the cerebral mantle, in regions which were also associated with BD. Higher BMI in people with BD indicated more pronounced brain alterations. BMI is important for understanding the neuroanatomical changes in BD and the effects of psychiatric medications on the brain.

Published
2023

16. Reproducibility in the absence of selective reporting : An illustration from large-scale brain asymmetry research

Author

Kong, Xiang-Zhen, Francks, Clyde, Allen, Nicholas B., Heslenfeld, Dirk, Hester, Robert, Hibar, Derrek Paul, Ho, Beng-Choon, Ho, Tiffany C., Hoekstra, Pieter J., Holst, Ruth J., Hoogman, Martine, Høvik, Marie F., Howells, Fleur M., Ames, David, Hugdahl, Kenneth, Huyser, Chaim, Ingvar, Martin, Ishikawa, Akari, James, Anthony, Jahanshad, Neda, Jernigan, Terry L., Jönsson, Erik G, Kaleda, Vasily, Kelly, Clare, Andreassen, Ole A., Kerich, Michael, Keshavan, Matcheri S., Khadka, Sabin, Kircher, Tilo, Kohls, Gregor, Konrad, Kerstin, Korucuoglu, Ozlem, Krämer, Bernd, Krug, Axel, Kuntsi, Jonna, Vasquez, Alejandro Arias, Kwon, Jun Soo, Lambregts-Rommelse, Nanda, Landén, Mikael, Lázaro, Luisa, Lebedeva, Irina, Lenroot, Rhoshel, Lesch, Klaus-Peter, Li, Qinqin, Lim, Kelvin O., Liu, Jia, Armstrong, Nicola J., Lochner, Christine, London, Edythe D., Lorenzetti, Valentina, Luciano, Michelle, Luijten, Maartje, Lundervold, Astri J., Mackey, Scott, MacMaster, Frank P., Maingault, Sophie, Malpas, Charles B., Asherson, Phil, Malt, Ulrik F., Mataix-Cols, David, Martin-Santos, Rocio, Mayer, Andrew R., McCarthy, Hazel, Medland, Sarah, Metha, Mitul, Mitchell, Philip B., Mueller, Bryon A., Maniega, Susana Muñoz, Bergo, Felipe, Mazoyer, Bernard, McDonald, Colm, McLellan, Quinn, McMahon, Katie L., McPhilemy, Genevieve, Momenan, Reza, Morales, Angelica M., Narayanaswamy, Janardhanan C., Moreira, José Carlos Vasques, Nerland, Stener, Bastin, Mark E., Nestor, Liam, Newman, Erik, Nigg, Joel T., Nordvik, Jan Egil, Novotny, Stephanie, Weiss, Eileen Oberwelland, O'Gorman, Ruth L., Oosterlaan, Jaap, Oranje, Bob, Orr, Catherine, Batalla, Albert, Overs, Bronwyn, Paloyelis, Yannis, Pauli, Paul, Paulus, Martin, Plessen, Kerstin Jessica, Polier, Georg G., Pomarol-Clotet, Edith, Portella, Maria J., Qiu, Jiang, Radua, Joaquim, Bauer, Jochen, Ramos-Quiroga, Josep Antoni, Reddy, Y. C. Janardhan, Reif, Andreas, Roberts, Gloria, Rosa, Pedro, Rubia, Katya, Sacchet, Matthew D., Sachdev, Perminder S., Salvador, Raymond, Schmaal, Lianne, Baune, Bernhard T, Schulte-Rüther, Martin, Schweren, Lizanne, Seitz, Jochen, Serpa, Mauricio Henriques, Shaw, Philip, Shumskaya, Elena, Silk, Timothy J., Simmons, Alan N., Simulionyte, Egle, Sinha, Rajita, Baur-Streubel, Ramona, Sjoerds, Zsuzsika, Smelror, Runar Elle, Soliva, Joan Carlos, Solowij, Nadia, Souza-Duran, Fabio Luisde, Sponheim, Scott R., Stein, Dan J., Stein, Elliot A., Stevens, Michael, Strike, Lachlan T., Biederman, Joseph, Sudre, Gustavo, Sui, Jing, Tamm, Leanne, Temmingh, Hendrik S., Thoma, Robert J., Tomyshev, Alexander, Tronchin, Giulia, Turner, Jessica, Uhlmann, Anne, Erp, Theo G. M., Blaine, Sara K., Heuvel, Odile A., Meer, Dennis, Eijk, Liza, Vance, Alasdair, Veer, Ilya M., Veltman, Dick J., Venkatasubramanian, Ganesan, Vilarroya, Oscar, Vives-Gilabert, Yolanda, Voineskos, Aristotle N, Boedhoe, Premika, Völzke, Henry, Vuletic, Daniella, Walitza, Susanne, Walter, Henrik, Walton, Esther, Wardlaw, Joanna M., Wen, Wei, Westlye, Lars T., Whelan, Christopher D., White, Tonya, Bøen, Erlend, Wiers, Reinout W., Wright, Margaret J., Wittfeld, Katharina, Yang, Tony T., Yasuda, Clarissa L., Yoncheva, Yuliya, Yücel, Murat, Yun, Je-Yeon, Zanetti, Marcus Vinicius, Zhen, Zonglei, Bose, Anushree, Zhu, Xing-xing, Ziegler, Georg C., Zubicaray, Greig I., Zwiers, Marcel, Project, Karolinska Schizophrenia, Glahn, David C., Crivello, Fabrice, Fisher, Simon E., Thompson, Paul M., Bralten, Janita, Farde, Lars, Flyckt, Lena, Engberg, Göran, Erhardt, Sophie, Fatouros-Bergman, Helena, Cervenka, Simon, Schwieler, Lilly, Piehl, Fredrik, Agartz, Ingrid, Collste, Karin, Brandeis, Daniel, Victorsson, Pauliina, Malmqvist, Anna, Hedberg, Mikael, Orhan, Funda, Sellgren, Carl, Brem, Silvia, Mathias, Samuel R., Brodaty, Henry, Yüksel, Dilara, Brooks, Samantha J., Buitelaar, Jan, Bürger, Christian, Bülow, Robin, Calhoun, Vince, Calvo, Anna, Canales-Rodríguez, Erick Jorge, Cannon, Dara M., Guadalupe, Tulio, Caparelli, Elisabeth C., Castellanos, Francisco X., Cendes, Fernando, Chaim-Avancini, Tiffany Moukbel, Chantiluke, Kaylita, Chen, Qun-lin, Chen, Xiayu, Cheng, Yuqi, Christakou, Anastasia, Clark, Vincent P., Abé, Christoph, Coghill, David, Connolly, Colm G., Conzelmann, Annette, Córdova-Palomera, Aldo, Cousijn, Janna, Crow, Tim, Cubillo, Ana, Dannlowski, Udo, Bruttopilo, Sara Ambrosino, Zeeuw, Patrick, Deary, Ian J., Demeter, Damion V., Di Martino, Adriana, Dickie, Erin W, Dietsche, Bruno, Doan, Nhat Trung, Doherty, Colin P., Doyle, Alysa, Durston, Sarah, Earl, Eric, Akudjedu, Theophilus N., Ehrlich, Stefan, Ekman, Carl Johan, Elvsåshagen, Torbjørn, Epstein, Jeffery N., Fair, Damien A., Faraone, Stephen V., Fernández, Guillén, Flint, Claas, Filho, Geraldo Busatto, Förster, Katharina, Aleman, Andre, Fouche, Jean-Paul, Foxe, John J., Frodl, Thomas, Fuentes-Claramonte, Paola, Fullerton, Janice M., Garavan, Hugh, Santos Garcia, Danielle, Gotlib, Ian H., Goudriaan, Anna E., Grabe, Hans Jörgen, Alhusaini, Saud, Groenewold, Nynke A., Grotegerd, Dominik, Gruber, Oliver, Gurholt, Tiril, Haavik, Jan, Hahn, Tim, Hansell, Narelle K., Harris, Mathew A., Hartman, Catharina A., Carmen Valdés Hernández, Maria, Alhusaini, Saud, Del Carmen Valdés Hernández, Maria, Heslenfeld, Dirk, Hester, Robert, Hibar, Derrek Paul, Ho, Beng-Choon, Ho, Tiffany C., Hoekstra, Pieter J., van Holst, Ruth J., Hoogman, Martine, Høvik, Marie F., Allen, Nicholas B., Howells, Fleur M., Hugdahl, Kenneth, Huyser, Chaim, Ingvar, Martin, Ishikawa, Akari, James, Anthony, Jahanshad, Neda, Jernigan, Terry L., Jönsson, Erik G., Kaleda, Vasily, Ames, David, Kelly, Clare, Kerich, Michael, Keshavan, Matcheri S., Khadka, Sabin, Kircher, Tilo, Kohls, Gregor, Konrad, Kerstin, Korucuoglu, Ozlem, Krämer, Bernd, Krug, Axel, Andreassen, Ole A., Kuntsi, Jonna, Kwon, Jun Soo, Lambregts-Rommelse, Nanda, Landén, Mikael, Lázaro, Luisa, Lebedeva, Irina, Lenroot, Rhoshel, Lesch, Klaus-Peter, Li, Qinqin, Lim, Kelvin O., Vasquez, Alejandro Arias, Liu, Jia, Lochner, Christine, London, Edythe D., Lorenzetti, Valentina, Luciano, Michelle, Luijten, Maartje, Lundervold, Astri J., Mackey, Scott, MacMaster, Frank P., Maingault, Sophie, Armstrong, Nicola J., Malpas, Charles B., Malt, Ulrik F., Mataix-Cols, David, Martin-Santos, Rocio, Mayer, Andrew R., McCarthy, Hazel, Medland, Sarah, Metha, Mitul, Mitchell, Philip B., Mueller, Bryon A., Asherson, Phil, Maniega, Susana Muñoz, Mazoyer, Bernard, McDonald, Colm, McLellan, Quinn, McMahon, Katie L., McPhilemy, Genevieve, Momenan, Reza, Morales, Angelica M., Narayanaswamy, Janardhanan C., Moreira, José Carlos Vasques, Bergo, Felipe, Nerland, Stener, Nestor, Liam, Newman, Erik, Nigg, Joel T., Nordvik, Jan Egil, Novotny, Stephanie, Weiss, Eileen Oberwelland, O'Gorman, Ruth L., Oosterlaan, Jaap, Oranje, Bob, Bastin, Mark E., Orr, Catherine, Overs, Bronwyn, Paloyelis, Yannis, Pauli, Paul, Paulus, Martin, Plessen, Kerstin Jessica, von Polier, Georg G., Pomarol-Clotet, Edith, Portella, Maria J., Qiu, Jiang, Batalla, Albert, Radua, Joaquim, Ramos-Quiroga, Josep Antoni, Reddy, Y. C. Janardhan, Reif, Andreas, Roberts, Gloria, Rosa, Pedro, Rubia, Katya, Sacchet, Matthew D., Sachdev, Perminder S., Salvador, Raymond, Bauer, Jochen, Schmaal, Lianne, Schulte-Rüther, Martin, Schweren, Lizanne, Seitz, Jochen, Serpa, Mauricio Henriques, Shaw, Philip, Shumskaya, Elena, Silk, Timothy J., Simmons, Alan N., Simulionyte, Egle, Baune, Bernhard T., Sinha, Rajita, Sjoerds, Zsuzsika, Smelror, Runar Elle, Soliva, Joan Carlos, Solowij, Nadia, Souza-Duran, Fabio Luisde, Sponheim, Scott R., Stein, Dan J., Stein, Elliot A., Stevens, Michael, Baur-Streubel, Ramona, Strike, Lachlan T., Sudre, Gustavo, Sui, Jing, Tamm, Leanne, Temmingh, Hendrik S., Thoma, Robert J., Tomyshev, Alexander, Tronchin, Giulia, Turner, Jessica, Uhlmann, Anne, Biederman, Joseph, van Erp, Theo G. M., van den Heuvel, Odile A., van der Meer, Dennis, van Eijk, Liza, Vance, Alasdair, Veer, Ilya M., Veltman, Dick J., Venkatasubramanian, Ganesan, Vilarroya, Oscar, Vives-Gilabert, Yolanda, Blaine, Sara K., Voineskos, Aristotle N., Völzke, Henry, Vuletic, Daniella, Walitza, Susanne, Walter, Henrik, Walton, Esther, Wardlaw, Joanna M., Wen, Wei, Westlye, Lars T., Whelan, Christopher D., Boedhoe, Premika, White, Tonya, Wiers, Reinout W., Wright, Margaret J., Wittfeld, Katharina, Yang, Tony T., Yasuda, Clarissa L., Yoncheva, Yuliya, Yücel, Murat, Yun, Je-Yeon, Zanetti, Marcus Vinicius, Bøen, Erlend, Zhen, Zonglei, Zhu, Xing-Xing, Ziegler, Georg C., de Zubicaray, Greig I., Zwiers, Marcel, Project, Karolinska Schizophrenia, Glahn, David C., Crivello, Fabrice, Fisher, Simon E., Thompson, Paul M., Bose, Anushree, Francks, Clyde, Farde, Lars, Flyckt, Lena, Engberg, Göran, Erhardt, Sophie, Fatouros-Bergman, Helena, Cervenka, Simon, Schwieler, Lilly, Piehl, Fredrik, Agartz, Ingrid, Bralten, Janita, Collste, Karin, Victorsson, Pauliina, Malmqvist, Anna, Hedberg, Mikael, Orhan, Funda, Sellgren, Carl, Brandeis, Daniel, Kong, Xiang-Zhen, Brem, Silvia, Brodaty, Henry, Yüksel, Dilara, Brooks, Samantha J., Buitelaar, Jan, Bürger, Christian, Bülow, Robin, Calhoun, Vince, Calvo, Anna, Canales-Rodríguez, Erick Jorge, Mathias, Samuel R., Cannon, Dara M., Caparelli, Elisabeth C., Castellanos, Francisco X., Cendes, Fernando, Chaim-Avancini, Tiffany Moukbel, Chantiluke, Kaylita, Chen, Qun-Lin, Chen, Xiayu, Cheng, Yuqi, Christakou, Anastasia, Guadalupe, Tulio, Clark, Vincent P., Coghill, David, Connolly, Colm G., Conzelmann, Annette, Córdova-Palomera, Aldo, Cousijn, Janna, Crow, Tim, Cubillo, Ana, Dannlowski, Udo, de Bruttopilo, Sara Ambrosino, Abé, Christoph, de Zeeuw, Patrick, Deary, Ian J., Demeter, Damion V., Di Martino, Adriana, Dickie, Erin W., Dietsche, Bruno, Doan, Nhat Trung, Doherty, Colin P., Doyle, Alysa, Durston, Sarah, Earl, Eric, Ehrlich, Stefan, Ekman, Carl Johan, Elvsåshagen, Torbjørn, Epstein, Jeffery N., Fair, Damien A., Faraone, Stephen V., Fernández, Guillén, Flint, Claas, Filho, Geraldo Busatto, Akudjedu, Theophilus N., Förster, Katharina, Fouche, Jean-Paul, Foxe, John J., Frodl, Thomas, Fuentes-Claramonte, Paola, Fullerton, Janice M., Garavan, Hugh, do Santos Garcia, Danielle, Gotlib, Ian H., Goudriaan, Anna E., Aleman, Andre, Grabe, Hans Jörgen, Groenewold, Nynke A., Grotegerd, Dominik, Gruber, Oliver, Gurholt, Tiril, Haavik, Jan, Hahn, Tim, Hansell, Narelle K., Harris, Mathew A., Hartman, Catharina A., Ontwikkelingspsychologie (Psychologie, FMG), Adult Psychiatry, APH - Mental Health, ANS - Compulsivity, Impulsivity & Attention, Child and Adolescent Psychiatry & Psychosocial Care, Child Psychiatry, ANS - Cellular & Molecular Mechanisms, Laboratory Genetic Metabolic Diseases, Paediatrics, General Paediatrics, ARD - Amsterdam Reproduction and Development, Paediatric Pulmonology, Graduate School, and APH - Digital Health

Subjects
P‐hacking, Datasets as Topic, Publication bias, 0302 clinical medicine, 130 000 Cognitive Neurology & Memory, Statistics, team science, Brain asymmetry, Multicenter Studies as Topic, Cervell, Research Articles, Cerebral Cortex, Radiological and Ultrasound Technology, P-hacking, 05 social sciences, Brain, Cerebral cortex, Middle Aged, Magnetic Resonance Imaging, Discoveries in science, Escorça cerebral, Neurology, Biaix de publicació, Anatomy, Psychology, Research Article, Neuroinformatics, Adult, Adolescent, Neuroimaging, Descobriments científics, 050105 experimental psychology, Statistical power, 03 medical and health sciences, Young Adult, Magnetic resonance imaging, Imatges per ressonància magnètica, multisite collaboration, Humans, 0501 psychology and cognitive sciences, Radiology, Nuclear Medicine and imaging, ddc:610, reproducibility, Aged, publication bias, Reproducibility, Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], Perspective (graphical), Reproducibility of Results, Brain Cortical Thickness, Research data, Sample size determination, Dades de recerca, Neurology (clinical), Scale (map), Developmental Psychopathology, 030217 neurology & neurosurgery
Abstract

The problem of poor reproducibility of scientific findings has received much attention over recent years, in a variety of fields including psychology and neuroscience. The problem has been partly attributed to publication bias and unwanted practices such as p‐hacking. Low statistical power in individual studies is also understood to be an important factor. In a recent multisite collaborative study, we mapped brain anatomical left–right asymmetries for regional measures of surface area and cortical thickness, in 99 MRI datasets from around the world, for a total of over 17,000 participants. In the present study, we revisited these hemispheric effects from the perspective of reproducibility. Within each dataset, we considered that an effect had been reproduced when it matched the meta‐analytic effect from the 98 other datasets, in terms of effect direction and significance threshold. In this sense, the results within each dataset were viewed as coming from separate studies in an “ideal publishing environment,” that is, free from selective reporting and p hacking. We found an average reproducibility rate of 63.2% (SD = 22.9%, min = 22.2%, max = 97.0%). As expected, reproducibility was higher for larger effects and in larger datasets. Reproducibility was not obviously related to the age of participants, scanner field strength, FreeSurfer software version, cortical regional measurement reliability, or regional size. These findings constitute an empirical illustration of reproducibility in the absence of publication bias or p hacking, when assessing realistic biological effects in heterogeneous neuroscience data, and given typically‐used sample sizes., Region‐wise effect sizes and reproducibility rates of hemispheric asymmetry effects. In general, effects with higher effect sizes showed higher reproducibility, given the same conditions (e.g., sample size and data heterogeneity).

Published
2022

21. Longitudinal Structural Brain Changes in Bipolar Disorder: A Multicenter Neuroimaging Study of 1232 Individuals by the ENIGMA Bipolar Disorder Working Group

Author

Abé, Christoph, primary, Ching, Christopher R.K., additional, Liberg, Benny, additional, Lebedev, Alexander V., additional, Agartz, Ingrid, additional, Akudjedu, Theophilus N., additional, Alda, Martin, additional, Alnæs, Dag, additional, Alonso-Lana, Silvia, additional, Benedetti, Francesco, additional, Berk, Michael, additional, Bøen, Erlend, additional, Bonnin, Caterina del Mar, additional, Breuer, Fabian, additional, Brosch, Katharina, additional, Brouwer, Rachel M., additional, Canales-Rodríguez, Erick J., additional, Cannon, Dara M., additional, Chye, Yann, additional, Dahl, Andreas, additional, Dandash, Orwa, additional, Dannlowski, Udo, additional, Dohm, Katharina, additional, Elvsåshagen, Torbjørn, additional, Fisch, Lukas, additional, Fullerton, Janice M., additional, Goikolea, Jose M., additional, Grotegerd, Dominik, additional, Haatveit, Beathe, additional, Hahn, Tim, additional, Hajek, Tomas, additional, Heindel, Walter, additional, Ingvar, Martin, additional, Sim, Kang, additional, Kircher, Tilo T.J., additional, Lenroot, Rhoshel K., additional, Malt, Ulrik F., additional, McDonald, Colm, additional, McWhinney, Sean R., additional, Melle, Ingrid, additional, Meller, Tina, additional, Melloni, Elisa M.T., additional, Mitchell, Philip B., additional, Nabulsi, Leila, additional, Nenadić, Igor, additional, Opel, Nils, additional, Overs, Bronwyn J., additional, Panicalli, Francesco, additional, Pfarr, Julia-Katharina, additional, Poletti, Sara, additional, Pomarol-Clotet, Edith, additional, Radua, Joaquim, additional, Repple, Jonathan, additional, Ringwald, Kai G., additional, Roberts, Gloria, additional, Rodriguez-Cano, Elena, additional, Salvador, Raymond, additional, Sarink, Kelvin, additional, Sarró, Salvador, additional, Schmitt, Simon, additional, Stein, Frederike, additional, Suo, Chao, additional, Thomopoulos, Sophia I., additional, Tronchin, Giulia, additional, Vieta, Eduard, additional, Westlye, Lars T., additional, White, Adam G., additional, Yatham, Lakshmi N., additional, Zak, Nathalia, additional, Thompson, Paul M., additional, Andreassen, Ole A., additional, and Landén, Mikael, additional

Published
2022
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26. Smaller stress-sensitive hippocampal subfields in women with borderline personality disorder without posttraumatic stress disorder

Author

Boen, Erlend, Westlye, Lars T., Elvsashagen, Torbjorn, Hummelen, Benjamin, Hol, Per K., Boye, Birgitte, Andersson, Stein, Karterud, Sigmund, and Malt, Ulrik F.

Subjects
Hippocampus (Brain) -- Physiological aspects, Borderline personality disorder -- Diagnosis -- Demographic aspects, Post-traumatic stress disorder -- Demographic aspects -- Diagnosis, Stress (Psychology) -- Physiological aspects, Health, Psychology and mental health
Abstract

Background: Animal and human studies have suggested that hippocampal subfields are differentially vulnerable to stress, but subfield volume has not been investigated in patients with borderline personality disorder (BPD). Based on the putative role of stressful life events as vulnerability factors for BPD, we hypothesized that patients with BPD would exhibit reduced volumes for the stress-sensitive dentate gyrus (DG) and the cornu ammonis (CA) 3 subfields volumes, and that these volumes would be associated with traumatic childhood experiences. Methods: All participants underwent 3 T magnetic resonance imaging. Hippocampal subfield volumes were estimated using an automated and validated segmentation algorithm implemented in FreeSurfer. Age and total subcortical grey matter volume were covariates. We assessed traumatic childhood experiences using the Childhood Trauma Questionnaire (CTQ). Results: A total of 18 women with BPD and 21 healthy control women were included in the study. Only 1 patient had comorbid posttraumatic stress disorder (PTSD). The volumes of the left (p = 0.005) and right (p = 0.011) DG-CA4 and left (p = 0.007) and right (p = 0.005) CA2-3 subfields were significantly reduced in patients compared with controls. We also found significant group differences for the left (p = 0.032) and right (p = 0.028) CA1, but not for other hippocampal subfields. No associations were found between CTQ scores and subfield volumes. Limitations: The self-reported CTQ might be inferior to more comprehensive assessments of traumatic experiences. The sample size was moderate. Conclusion: The volumes of stress-sensitive hippocampal subfields are reduced in women with BPD without PTSD. However, the degree to which childhood trauma is responsible for these changes is unclear., Introduction Borderline personality disorder (BPD) is a severe, chronic psychiatric disorder with high morbidity and mortality. (1) The etiology of BPD is far from being elucidated. Childhood traumatization may be [...]

Published
2014
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27. The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data

Author

Thompson, Paul M., Stein, Jason L., Medland, Sarah E., Hibar, Derrek P., Vasquez, Alejandro Arias, Renteria, Miguel E., Toro, Roberto, Jahanshad, Neda, Schumann, Gunter, Franke, Barbara, Wright, Margaret J., Martin, Nicholas G., Agartz, Ingrid, Alda, Martin, Alhusaini, Saud, Almasy, Laura, Almeida, Jorge, Alpert, Kathryn, Andreasen, Nancy C., Andreassen, Ole A., Apostolova, Liana G., Appel, Katja, Armstrong, Nicola J., Aribisala, Benjamin, Bastin, Mark E., Bauer, Michael, Bearden, Carrie E., Bergmann, Ørjan, Binder, Elisabeth B., Blangero, John, Bockholt, Henry J., Bøen, Erlend, Bois, Catherine, Boomsma, Dorret I., Booth, Tom, Bowman, Ian J., Bralten, Janita, Brouwer, Rachel M., Brunner, Han G., Brohawn, David G., Buckner, Randy L., Buitelaar, Jan, Bulayeva, Kazima, Bustillo, Juan R., Calhoun, Vince D., Cannon, Dara M., Cantor, Rita M., Carless, Melanie A., Caseras, Xavier, Cavalleri, Gianpiero L., Chakravarty, M. Mallar, Chang, Kiki D., Ching, Christopher R. K., Christoforou, Andrea, Cichon, Sven, Clark, Vincent P., Conrod, Patricia, Coppola, Giovanni, Crespo-Facorro, Benedicto, Curran, Joanne E., Czisch, Michael, Deary, Ian J., de Geus, Eco J. C., den Braber, Anouk, Delvecchio, Giuseppe, Depondt, Chantal, de Haan, Lieuwe, de Zubicaray, Greig I., Dima, Danai, Dimitrova, Rali, Djurovic, Srdjan, Dong, Hongwei, Donohoe, Gary, Duggirala, Ravindranath, Dyer, Thomas D., Ehrlich, Stefan, Ekman, Carl Johan, Elvsåshagen, Torbjørn, Emsell, Louise, Erk, Susanne, Espeseth, Thomas, Fagerness, Jesen, Fears, Scott, Fedko, Iryna, Fernández, Guillén, Fisher, Simon E., Foroud, Tatiana, Fox, Peter T., Francks, Clyde, Frangou, Sophia, Frey, Eva Maria, Frodl, Thomas, Frouin, Vincent, Garavan, Hugh, Giddaluru, Sudheer, Glahn, David C., Godlewska, Beata, Goldstein, Rita Z., Gollub, Randy L., Grabe, Hans J., Grimm, Oliver, Gruber, Oliver, Guadalupe, Tulio, Gur, Raquel E., Gur, Ruben C., Göring, Harald H. H., Hagenaars, Saskia, Hajek, Tomas, Hall, Geoffrey B., Hall, Jeremy, Hardy, John, Hartman, Catharina A., Hass, Johanna, Hatton, Sean N., Haukvik, Unn K., Hegenscheid, Katrin, Heinz, Andreas, Hickie, Ian B., Ho, Beng-Choon, Hoehn, David, Hoekstra, Pieter J., Hollinshead, Marisa, Holmes, Avram J., Homuth, Georg, Hoogman, Martine, Hong, L. Elliot, Hosten, Norbert, Hottenga, Jouke-Jan, Hulshoff Pol, Hilleke E., Hwang, Kristy S., Jack, Jr, Clifford R., Jenkinson, Mark, Johnston, Caroline, Jönsson, Erik G., Kahn, René S., Kasperaviciute, Dalia, Kelly, Sinead, Kim, Sungeun, Kochunov, Peter, Koenders, Laura, Krämer, Bernd, Kwok, John B. J., Lagopoulos, Jim, Laje, Gonzalo, Landen, Mikael, Landman, Bennett A., Lauriello, John, Lawrie, Stephen M., Lee, Phil H., Le Hellard, Stephanie, Lemaître, Herve, Leonardo, Cassandra D., Li, Chiang-shan, Liberg, Benny, Liewald, David C., Liu, Xinmin, Lopez, Lorna M., Loth, Eva, Lourdusamy, Anbarasu, Luciano, Michelle, Macciardi, Fabio, Machielsen, Marise W. J., MacQueen, Glenda M., Malt, Ulrik F., Mandl, René, Manoach, Dara S., Martinot, Jean-Luc, Matarin, Mar, Mather, Karen A., Mattheisen, Manuel, Mattingsdal, Morten, Meyer-Lindenberg, Andreas, McDonald, Colm, McIntosh, Andrew M., McMahon, Francis J., McMahon, Katie L., Meisenzahl, Eva, Melle, Ingrid, Milaneschi, Yuri, Mohnke, Sebastian, Montgomery, Grant W., Morris, Derek W., Moses, Eric K., Mueller, Bryon A., Muñoz Maniega, Susana, Mühleisen, Thomas W., Müller-Myhsok, Bertram, Mwangi, Benson, Nauck, Matthias, Nho, Kwangsik, Nichols, Thomas E., Nilsson, Lars-Göran, Nugent, Allison C., Nyberg, Lars, Olvera, Rene L., Oosterlaan, Jaap, Ophoff, Roel A., Pandolfo, Massimo, Papalampropoulou-Tsiridou, Melina, Papmeyer, Martina, Paus, Tomas, Pausova, Zdenka, Pearlson, Godfrey D., Penninx, Brenda W., Peterson, Charles P., Pfennig, Andrea, Phillips, Mary, Pike, G. Bruce, Poline, Jean-Baptiste, Potkin, Steven G., Pütz, Benno, Ramasamy, Adaikalavan, Rasmussen, Jerod, Rietschel, Marcella, Rijpkema, Mark, Risacher, Shannon L., Roffman, Joshua L., Roiz-Santiañez, Roberto, Romanczuk-Seiferth, Nina, Rose, Emma J., Royle, Natalie A., Rujescu, Dan, Ryten, Mina, Sachdev, Perminder S., Salami, Alireza, Satterthwaite, Theodore D., Savitz, Jonathan, Saykin, Andrew J., Scanlon, Cathy, Schmaal, Lianne, Schnack, Hugo G., Schork, Andrew J., Schulz, S. Charles, Schür, Remmelt, Seidman, Larry, Shen, Li, Shoemaker, Jody M., Simmons, Andrew, Sisodiya, Sanjay M., Smith, Colin, Smoller, Jordan W., Soares, Jair C., Sponheim, Scott R., Sprooten, Emma, Starr, John M., Steen, Vidar M., Strakowski, Stephen, Strike, Lachlan, Sussmann, Jessika, Sämann, Philipp G., Teumer, Alexander, Toga, Arthur W., Tordesillas-Gutierrez, Diana, Trabzuni, Daniah, Trost, Sarah, Turner, Jessica, Van den Heuvel, Martijn, van der Wee, Nic J., van Eijk, Kristel, van Erp, Theo G. M., van Haren, Neeltje E. M., van ‘t Ent, Dennis, van Tol, Marie-Jose, Valdés Hernández, Maria C., Veltman, Dick J., Versace, Amelia, Völzke, Henry, Walker, Robert, Walter, Henrik, Wang, Lei, Wardlaw, Joanna M., Weale, Michael E., Weiner, Michael W., Wen, Wei, Westlye, Lars T., Whalley, Heather C., Whelan, Christopher D., White, Tonya, Winkler, Anderson M., Wittfeld, Katharina, Woldehawariat, Girma, Wolf, Christiane, Zilles, David, Zwiers, Marcel P., Thalamuthu, Anbupalam, Schofield, Peter R., Freimer, Nelson B., Lawrence, Natalia S., Drevets, Wayne, and the Alzheimer’s Disease Neuroimaging Initiative, EPIGEN Consortium, IMAGEN Consortium, Saguenay Youth Study (SYS) Group

Published
2014
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28. The brain functional connectome is robustly altered by lack of sleep

Author

Kaufmann, Tobias, Elvsåshagen, Torbjrn, Alnæs, Dag, Zak, Nathalia, Pedersen, Per ., Norbom, Linn B., Quraishi, Sophia H., Tagliazucchi, Enzo, Laufs, Helmut, Bjrnerud, Atle, Malt, Ulrik F., Andreassen, Ole A., Roussos, Evangelos, Duff, Eugene P., Smith, Stephen M., Groote, Inge R., and Westlye, Lars T.

Published
2016
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33. Evidence for widespread alterations in cortical microstructure after 32 hours of sleep deprivation

Author

Voldsbekk, Irene, primary, Bjørnerud, Atle, additional, Groote, Inge, additional, Zak, Nathalia, additional, Roelfs, Daniel, additional, Maximov, Ivan I., additional, Geier, Oliver, additional, Due-Tønnessen, Paulina, additional, Bøen, Erlend, additional, Kuiper, Yvonne S., additional, Løkken, Lise-Linn, additional, Strømstad, Marie, additional, Blakstvedt, Taran Y., additional, Bjorvatn, Bjørn, additional, Malt, Ulrik F., additional, Westlye, Lars T., additional, Elvsåshagen, Torbjørn, additional, and Grydeland, Håkon, additional

Published
2021
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34. Brain aging in major depressive disorder: Results from the ENIGMA major depressive disorder working group

Author

Han, Laura K M, Dinga, Richard, Hahn, Tim, Ching, Christopher R K, Eyler, Lisa T, Aftanas, Lyubomir, Aghajani, Moji, Aleman, André, Baune, Bernhard T, Berger, Klaus, Brak, Ivan, Filho, Geraldo Busatto, Carballedo, Angela, Connolly, Colm G, Couvy-Duchesne, Baptiste, Cullen, Kathryn R, Dannlowski, Udo, Davey, Christopher G, Dima, Danai, Duran, Fabio L S, Enneking, Verena, Filimonova, Elena, Frenzel, Stefan, Frodl, Thomas, Fu, Cynthia H Y, Godlewska, Beata R, Gotlib, Ian H, Grabe, Hans J, Groenewold, Nynke A, Grotegerd, Dominik, Gruber, Oliver, Hall, Geoffrey B, Harrison, Ben J, Hatton, Sean N, Hermesdorf, Marco, Hickie, Ian B, Ho, Tiffany C, Hosten, Norbert, Jansen, Andreas, Kähler, Claas, Kircher, Tilo, Klimes-Dougan, Bonnie, Krämer, Bernd, Krug, Axel, Lagopoulos, Jim, Leenings, Ramona, MacMaster, Frank P, MacQueen, Glenda, McIntosh, Andrew, McLellan, Quinn, McMahon, Katie L, Medland, Sarah E, Mueller, Bryon A, Mwangi, Benson, Osipov, Evgeny, Portella, Maria J, Pozzi, Elena, Reneman, Liesbeth, Repple, Jonathan, Rosa, Pedro G P, Sacchet, Matthew D, Sämann, Philipp G, Schnell, Knut, Schrantee, Anouk, Simulionyte, Egle, Soares, Jair C, Sommer, Jens, Stein, Dan J, Steinsträter, Olaf, Strike, Lachlan T, Thomopoulos, Sophia I, van Tol, Marie-José, Veer, Ilya M, Vermeiren, Robert R J M, Walter, Henrik, van der Wee, Nic J A, van der Werff, Steven J A, Whalley, Heather, Winter, Nils R, Wittfeld, Katharina, Wright, Margaret J, Wu, Mon-Ju, Völzke, Henry, Yang, Tony T, Zannias, Vasileios, de Zubicaray, Greig I, Zunta-Soares, Giovana B, Abé, Christoph, Alda, Martin, Andreassen, Ole A, Bøen, Erlend, Bonnin, Caterina M, Canales-Rodriguez, Erick J, Cannon, Dara, Caseras, Xavier, Chaim-Avancini, Tiffany M, Elvsåshagen, Torbjørn, Favre, Pauline, Foley, Sonya F, Fullerton, Janice M, Goikolea, Jose M, Haarman, Bartholomeus C M, Hajek, Tomas, Henry, Chantal, Houenou, Josselin, Howells, Fleur M, Ingvar, Martin, Kuplicki, Rayus, Lafer, Beny, Landén, Mikael, Machado-Vieira, Rodrigo, Malt, Ulrik F, McDonald, Colm, Mitchell, Philip B, Nabulsi, Leila, Otaduy, Maria Concepcion Garcia, Overs, Bronwyn J, Polosan, Mircea, Pomarol-Clotet, Edith, Radua, Joaquim, Rive, Maria M, Roberts, Gloria, Ruhe, Henricus G, Salvador, Raymond, Sarró, Salvador, Satterthwaite, Theodore D, Savitz, Jonathan, Schene, Aart H, Schofield, Peter R, Serpa, Mauricio H, Sim, Kang, Soeiro-de-Souza, Marcio Gerhardt, Sutherland, Ashley N, Temmingh, Henk S, Timmons, Garrett M, Uhlmann, Anne, Vieta, Eduard, Wolf, Daniel H, Zanetti, Marcus V, Jahanshad, Neda, Thompson, Paul M, Veltman, Dick J, Penninx, Brenda W J H, Marquand, Andre F, Cole, James H, Schmaal, Lianne, Han, Laura K M, Dinga, Richard, Hahn, Tim, Ching, Christopher R K, Eyler, Lisa T, Aftanas, Lyubomir, Aghajani, Moji, Aleman, André, Baune, Bernhard T, Berger, Klaus, Brak, Ivan, Filho, Geraldo Busatto, Carballedo, Angela, Connolly, Colm G, Couvy-Duchesne, Baptiste, Cullen, Kathryn R, Dannlowski, Udo, Davey, Christopher G, Dima, Danai, Duran, Fabio L S, Enneking, Verena, Filimonova, Elena, Frenzel, Stefan, Frodl, Thomas, Fu, Cynthia H Y, Godlewska, Beata R, Gotlib, Ian H, Grabe, Hans J, Groenewold, Nynke A, Grotegerd, Dominik, Gruber, Oliver, Hall, Geoffrey B, Harrison, Ben J, Hatton, Sean N, Hermesdorf, Marco, Hickie, Ian B, Ho, Tiffany C, Hosten, Norbert, Jansen, Andreas, Kähler, Claas, Kircher, Tilo, Klimes-Dougan, Bonnie, Krämer, Bernd, Krug, Axel, Lagopoulos, Jim, Leenings, Ramona, MacMaster, Frank P, MacQueen, Glenda, McIntosh, Andrew, McLellan, Quinn, McMahon, Katie L, Medland, Sarah E, Mueller, Bryon A, Mwangi, Benson, Osipov, Evgeny, Portella, Maria J, Pozzi, Elena, Reneman, Liesbeth, Repple, Jonathan, Rosa, Pedro G P, Sacchet, Matthew D, Sämann, Philipp G, Schnell, Knut, Schrantee, Anouk, Simulionyte, Egle, Soares, Jair C, Sommer, Jens, Stein, Dan J, Steinsträter, Olaf, Strike, Lachlan T, Thomopoulos, Sophia I, van Tol, Marie-José, Veer, Ilya M, Vermeiren, Robert R J M, Walter, Henrik, van der Wee, Nic J A, van der Werff, Steven J A, Whalley, Heather, Winter, Nils R, Wittfeld, Katharina, Wright, Margaret J, Wu, Mon-Ju, Völzke, Henry, Yang, Tony T, Zannias, Vasileios, de Zubicaray, Greig I, Zunta-Soares, Giovana B, Abé, Christoph, Alda, Martin, Andreassen, Ole A, Bøen, Erlend, Bonnin, Caterina M, Canales-Rodriguez, Erick J, Cannon, Dara, Caseras, Xavier, Chaim-Avancini, Tiffany M, Elvsåshagen, Torbjørn, Favre, Pauline, Foley, Sonya F, Fullerton, Janice M, Goikolea, Jose M, Haarman, Bartholomeus C M, Hajek, Tomas, Henry, Chantal, Houenou, Josselin, Howells, Fleur M, Ingvar, Martin, Kuplicki, Rayus, Lafer, Beny, Landén, Mikael, Machado-Vieira, Rodrigo, Malt, Ulrik F, McDonald, Colm, Mitchell, Philip B, Nabulsi, Leila, Otaduy, Maria Concepcion Garcia, Overs, Bronwyn J, Polosan, Mircea, Pomarol-Clotet, Edith, Radua, Joaquim, Rive, Maria M, Roberts, Gloria, Ruhe, Henricus G, Salvador, Raymond, Sarró, Salvador, Satterthwaite, Theodore D, Savitz, Jonathan, Schene, Aart H, Schofield, Peter R, Serpa, Mauricio H, Sim, Kang, Soeiro-de-Souza, Marcio Gerhardt, Sutherland, Ashley N, Temmingh, Henk S, Timmons, Garrett M, Uhlmann, Anne, Vieta, Eduard, Wolf, Daniel H, Zanetti, Marcus V, Jahanshad, Neda, Thompson, Paul M, Veltman, Dick J, Penninx, Brenda W J H, Marquand, Andre F, Cole, James H, and Schmaal, Lianne

Abstract

Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced brain aging in adult MDD patients, and whether this process is associated with clinical characteristics in a large multicenter international dataset. We performed a mega-analysis by pooling brain measures derived from T1-weighted MRI scans from 19 samples worldwide. Healthy brain aging was estimated by predicting chronological age (18-75 years) from 7 subcortical volumes, 34 cortical thickness and 34 surface area, lateral ventricles and total intracranial volume measures separately in 952 male and 1236 female controls from the ENIGMA MDD working group. The learned model coefficients were applied to 927 male controls and 986 depressed males, and 1199 female controls and 1689 depressed females to obtain independent unbiased brain-based age predictions. The difference between predicted "brain age" and chronological age was calculated to indicate brain-predicted age difference (brain-PAD). On average, MDD patients showed a higher brain-PAD of +1.08 (SE 0.22) years (Cohen's d = 0.14, 95% CI: 0.08-0.20) compared with controls. However, this difference did not seem to be driven by specific clinical characteristics (recurrent status, remission status, antidepressant medication use, age of onset, or symptom severity). This highly powered collaborative effort showed subtle patterns of age-related structural brain abnormalities in MDD. Substantial within-group variance and overlap between groups were observed. Longitudinal studies of MDD and somatic health outcomes are needed to further assess the clinical value of these brain-PAD estimates.

Published
2021

35. Association between body mass index and subcortical brain volumes in bipolar disorders–ENIGMA study in 2735 individuals

Author

McWhinney, Sean R., Abé, Christoph, Alda, Martin, Benedetti, Francesco, Bøen, Erlend, del Mar Bonnin, Caterina, Borgers, Tiana, Brosch, Katharina, Canales-Rodríguez, Erick J., Cannon, Dara M., Dannlowski, Udo, Díaz-Zuluaga, Ana M., Elvsåshagen, Torbjørn, Eyler, Lisa T., Fullerton, Janice M., Goikolea, Jose M., Goltermann, Janik, Grotegerd, Dominik, Haarman, Bartholomeus C.M., Hahn, Tim, Howells, Fleur M., Ingvar, Martin, Kircher, Tilo T.J., Krug, Axel, Kuplicki, Rayus T., Landén, Mikael, Lemke, Hannah, Liberg, Benny, Lopez-Jaramillo, Carlos, Malt, Ulrik F., Martyn, Fiona M., Mazza, Elena, McDonald, Colm, McPhilemy, Genevieve, Meier, Sandra, Meinert, Susanne, Meller, Tina, Melloni, Elisa M.T., Mitchell, Philip B., Nabulsi, Leila, Nenadic, Igor, Opel, Nils, Ophoff, Roel A., Overs, Bronwyn J., Pfarr, Julia Katharina, Pineda-Zapata, Julian A., Pomarol-Clotet, Edith, Raduà, Joaquim, van Haren, Neeltje E.M., Vreeker, Annabel, Thompson, Paul M, Hajek, Tomas, McWhinney, Sean R., Abé, Christoph, Alda, Martin, Benedetti, Francesco, Bøen, Erlend, del Mar Bonnin, Caterina, Borgers, Tiana, Brosch, Katharina, Canales-Rodríguez, Erick J., Cannon, Dara M., Dannlowski, Udo, Díaz-Zuluaga, Ana M., Elvsåshagen, Torbjørn, Eyler, Lisa T., Fullerton, Janice M., Goikolea, Jose M., Goltermann, Janik, Grotegerd, Dominik, Haarman, Bartholomeus C.M., Hahn, Tim, Howells, Fleur M., Ingvar, Martin, Kircher, Tilo T.J., Krug, Axel, Kuplicki, Rayus T., Landén, Mikael, Lemke, Hannah, Liberg, Benny, Lopez-Jaramillo, Carlos, Malt, Ulrik F., Martyn, Fiona M., Mazza, Elena, McDonald, Colm, McPhilemy, Genevieve, Meier, Sandra, Meinert, Susanne, Meller, Tina, Melloni, Elisa M.T., Mitchell, Philip B., Nabulsi, Leila, Nenadic, Igor, Opel, Nils, Ophoff, Roel A., Overs, Bronwyn J., Pfarr, Julia Katharina, Pineda-Zapata, Julian A., Pomarol-Clotet, Edith, Raduà, Joaquim, van Haren, Neeltje E.M., Vreeker, Annabel, Thompson, Paul M, and Hajek, Tomas

Abstract

Individuals with bipolar disorders (BD) frequently suffer from obesity, which is often associated with neurostructural alterations. Yet, the effects of obesity on brain structure in BD are under-researched. We obtained MRI-derived brain subcortical volumes and body mass index (BMI) from 1134 BD and 1601 control individuals from 17 independent research sites within the ENIGMA-BD Working Group. We jointly modeled the effects of BD and BMI on subcortical volumes using mixed-effects modeling and tested for mediation of group differences by obesity using nonparametric bootstrapping. All models controlled for age, sex, hemisphere, total intracranial volume, and data collection site. Relative to controls, individuals with BD had significantly higher BMI, larger lateral ventricular volume, and smaller volumes of amygdala, hippocampus, pallidum, caudate, and thalamus. BMI was positively associated with ventricular and amygdala and negatively with pallidal volumes. When analyzed jointly, both BD and BMI remained associated with volumes of lateral ventricles and amygdala. Adjusting for BMI decreased the BD vs control differences in ventricular volume. Specifically, 18.41% of the association between BD and ventricular volume was mediated by BMI (Z = 2.73, p = 0.006). BMI was associated with similar regional brain volumes as BD, including lateral ventricles, amygdala, and pallidum. Higher BMI may in part account for larger ventricles, one of the most replicated findings in BD. Comorbidity with obesity could explain why neurostructural alterations are more pronounced in some individuals with BD. Future prospective brain imaging studies should investigate whether obesity could be a modifiable risk factor for neuroprogression.

Published
2021

38. General and comparative efficacy and effectiveness of antidepressants in the acute treatment of depressive disorders: a report by the WPA section of pharmacopsychiatry

Author

Baghai, Thomas C., Blier, Pierre, Baldwin, David S., Bauer, Michael, Goodwin, Guy M., Fountoulakis, Kostas N., Kasper, Siegfried, Leonard, Brian E., Malt, Ulrik F., Stein, Dan, Versiani, Marcio, Möller, Hans-Jürgen, and for the Section of Pharmacopsychiatry, World Psychiatric Association

Published
2011
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42. Publisher Correction:Common brain disorders are associated with heritable patterns of apparent aging of the brain (Nature Neuroscience, (2019), 22, 10, (1617-1623), 10.1038/s41593-019-0471-7)

Author

Kaufmann, Tobias, van der Meer, Dennis, Doan, Nhat Trung, Schwarz, Emanuel, Lund, Martina J., Agartz, Ingrid, Alnæs, Dag, Barch, Deanna M., Baur-Streubel, Ramona, Bertolino, Alessandro, Bettella, Francesco, Beyer, Mona K., Bøen, Erlend, Borgwardt, Stefan, Brandt, Christine L., Buitelaar, Jan, Celius, Elisabeth G., Cervenka, Simon, Conzelmann, Annette, Córdova-Palomera, Aldo, Dale, Anders M., de Quervain, Dominique J.F., Di Carlo, Pasquale, Djurovic, Srdjan, Dørum, Erlend S., Eisenacher, Sarah, Elvsåshagen, Torbjørn, Espeseth, Thomas, Fatouros-Bergman, Helena, Flyckt, Lena, Franke, Barbara, Frei, Oleksandr, Haatveit, Beathe, Håberg, Asta K., Harbo, Hanne F., Hartman, Catharina A., Heslenfeld, Dirk, Hoekstra, Pieter J., Høgestøl, Einar A., Jernigan, Terry L., Jonassen, Rune, Jönsson, Erik G., Farde, Lars, Engberg, Göran, Erhardt, Sophie, Schwieler, Lilly, Piehl, Fredrik, Collste, Karin, Victorsson, Pauliina, Malmqvist, Anna, Hedberg, Mikael, Orhan, Funda, Kirsch, Peter, Kłoszewska, Iwona, Kolskår, Knut K., Landrø, Nils Inge, Le Hellard, Stephanie, Lesch, Klaus Peter, Lovestone, Simon, Lundervold, Arvid, Lundervold, Astri J., Maglanoc, Luigi A., Malt, Ulrik F., Mecocci, Patrizia, Melle, Ingrid, Meyer-Lindenberg, Andreas, Moberget, Torgeir, Norbom, Linn B., Nordvik, Jan Egil, Nyberg, Lars, Oosterlaan, Jaap, Papalino, Marco, Papassotiropoulos, Andreas, Pauli, Paul, Pergola, Giulio, Persson, Karin, Richard, Geneviève, Rokicki, Jaroslav, Sanders, Anne Marthe, Selbæk, Geir, Shadrin, Alexey A., Smeland, Olav B., Soininen, Hilkka, Sowa, Piotr, Steen, Vidar M., Tsolaki, Magda, Ulrichsen, Kristine M., Vellas, Bruno, Wang, Lei, Westman, Eric, Ziegler, Georg C., Zink, Mathias, Andreassen, Ole A., and Westlye, Lars T.

Subjects
ComputingMethodologies_DOCUMENTANDTEXTPROCESSING
Abstract

In the version of this article initially published, spaces were missing in the names of Stephanie Le Hellard and Pasquale Di Carlo. The errors have been corrected in the HTML and PDF versions of the article.

Published
2020

44. The genetic architecture of human brainstem structures and their involvement in common brain disorders

Author

Elvsåshagen, Torbjørn, Bahrami, Shahram, van der Meer, Dennis, Agartz, Ingrid, Alnæs, Dag, Barch, Deanna M, Baur-Streubel, Ramona, Bertolino, Alessandro, Beyer, Mona K, Blasi, Giuseppe, Borgwardt, Stefan, Boye, Birgitte, Buitelaar, Jan, Bøen, Erlend, Celius, Elisabeth Gulowsen, Cervenka, Simon, Conzelmann, Annette, Coynel, David, Di Carlo, Pasquale, Djurovic, Srdjan, Eisenacher, Sarah, Espeseth, Thomas, Fatouros-Bergman, Helena, Flyckt, Lena, Franke, Barbara, Frei, Oleksandr, Gelao, Barbara, Harbo, Hanne Flinstad, Hartman, Catharina A, Håberg, Asta, Heslenfeld, Dirk, Hoekstra, Pieter J, Høgestøl, Einar A, Jonassen, Rune, Jönsson, Erik G, Kirsch, Peter, Kłoszewska, Iwona, Lagerberg, Trine Vik, Landrø, Nils Inge, Le Hellard, Stephanie, Lesch, Klaus-Peter, Maglanoc, Luigi A, Malt, Ulrik F, Mecocci, Patrizia, Melle, Ingrid, Meyer-Lindenberg, Andreas, Moberget, Torgeir, Nordvik, Jan Egil, Nyberg, Lars, Connell, Kevin S O', Oosterlaan, Jaap, Papalino, Marco, Papassotiropoulos, Andreas, Pauli, Paul, Pergola, Giulio, Persson, Karin, de Quervain, Dominique, Reif, Andreas, Rokicki, Jaroslav, van Rooij, Daan, Shadrin, Alexey A, Schmidt, André, Schwarz, Emanuel, Selbæk, Geir, Soininen, Hilkka, Sowa, Piotr, Steen, Vidar M, Tsolaki, Magda, Vellas, Bruno, Wang, Lei, Westman, Eric, Ziegler, Georg C, Zink, Mathias, Andreassen, Ole A, Westlye, Lars T, Kaufmann, Tobias, Elvsåshagen, Torbjørn, Bahrami, Shahram, van der Meer, Dennis, Agartz, Ingrid, Alnæs, Dag, Barch, Deanna M, Baur-Streubel, Ramona, Bertolino, Alessandro, Beyer, Mona K, Blasi, Giuseppe, Borgwardt, Stefan, Boye, Birgitte, Buitelaar, Jan, Bøen, Erlend, Celius, Elisabeth Gulowsen, Cervenka, Simon, Conzelmann, Annette, Coynel, David, Di Carlo, Pasquale, Djurovic, Srdjan, Eisenacher, Sarah, Espeseth, Thomas, Fatouros-Bergman, Helena, Flyckt, Lena, Franke, Barbara, Frei, Oleksandr, Gelao, Barbara, Harbo, Hanne Flinstad, Hartman, Catharina A, Håberg, Asta, Heslenfeld, Dirk, Hoekstra, Pieter J, Høgestøl, Einar A, Jonassen, Rune, Jönsson, Erik G, Kirsch, Peter, Kłoszewska, Iwona, Lagerberg, Trine Vik, Landrø, Nils Inge, Le Hellard, Stephanie, Lesch, Klaus-Peter, Maglanoc, Luigi A, Malt, Ulrik F, Mecocci, Patrizia, Melle, Ingrid, Meyer-Lindenberg, Andreas, Moberget, Torgeir, Nordvik, Jan Egil, Nyberg, Lars, Connell, Kevin S O', Oosterlaan, Jaap, Papalino, Marco, Papassotiropoulos, Andreas, Pauli, Paul, Pergola, Giulio, Persson, Karin, de Quervain, Dominique, Reif, Andreas, Rokicki, Jaroslav, van Rooij, Daan, Shadrin, Alexey A, Schmidt, André, Schwarz, Emanuel, Selbæk, Geir, Soininen, Hilkka, Sowa, Piotr, Steen, Vidar M, Tsolaki, Magda, Vellas, Bruno, Wang, Lei, Westman, Eric, Ziegler, Georg C, Zink, Mathias, Andreassen, Ole A, Westlye, Lars T, and Kaufmann, Tobias

Abstract

Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, we identify 45 brainstem-associated genetic loci, including the first linked to midbrain, pons, and medulla oblongata volumes, and map them to 305 genes. In a replication sample of 7432 participants most of the loci show the same effect direction and are significant at a nominal threshold. We detect genetic overlap between brainstem volumes and eight psychiatric and neurological disorders. In additional clinical data from 5062 individuals with common brain disorders and 11,257 healthy controls, we observe differential volume alterations in schizophrenia, bipolar disorder, multiple sclerosis, mild cognitive impairment, dementia, and Parkinson's disease, supporting the relevance of brainstem regions and their genetic architectures in common brain disorders.

Published
2020
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45. Using structural MRI to identify bipolar disorders – 13 site machine learning study in 3020 individuals from the ENIGMA Bipolar Disorders Working Group

Author

Onderzoeksgroep 1, Onderzoek, Brain, Onderzoeksgroep 4, Nunes, Abraham, Schnack, Hugo G., Ching, Christopher R.K., Agartz, Ingrid, Akudjedu, Theophilus N., Alda, Martin, Alnæs, Dag, Alonso-Lana, Silvia, Bauer, Jochen, Baune, Bernhard T., Bøen, Erlend, Bonnin, Caterina del Mar, Busatto, Geraldo F., Canales-Rodríguez, Erick J., Cannon, Dara M., Caseras, Xavier, Chaim-Avancini, Tiffany M., Dannlowski, Udo, Díaz-Zuluaga, Ana M., Dietsche, Bruno, Doan, Nhat Trung, Duchesnay, Edouard, Elvsåshagen, Torbjørn, Emden, Daniel, Eyler, Lisa T., Fatjó-Vilas, Mar, Favre, Pauline, Foley, Sonya F., Fullerton, Janice M., Glahn, David C., Goikolea, Jose M., Grotegerd, Dominik, Hahn, Tim, Henry, Chantal, Hibar, Derrek P., Houenou, Josselin, Howells, Fleur M., Jahanshad, Neda, Kaufmann, Tobias, Kenney, Joanne, Kircher, Tilo T.J., Krug, Axel, Lagerberg, Trine V., Lenroot, Rhoshel K., López-Jaramillo, Carlos, Machado-Vieira, Rodrigo, Malt, Ulrik F., McDonald, Colm, Mitchell, Philip B., van Haren, Neeltje E.M., for the ENIGMA Bipolar Disorders Working Group, Onderzoeksgroep 1, Onderzoek, Brain, Onderzoeksgroep 4, Nunes, Abraham, Schnack, Hugo G., Ching, Christopher R.K., Agartz, Ingrid, Akudjedu, Theophilus N., Alda, Martin, Alnæs, Dag, Alonso-Lana, Silvia, Bauer, Jochen, Baune, Bernhard T., Bøen, Erlend, Bonnin, Caterina del Mar, Busatto, Geraldo F., Canales-Rodríguez, Erick J., Cannon, Dara M., Caseras, Xavier, Chaim-Avancini, Tiffany M., Dannlowski, Udo, Díaz-Zuluaga, Ana M., Dietsche, Bruno, Doan, Nhat Trung, Duchesnay, Edouard, Elvsåshagen, Torbjørn, Emden, Daniel, Eyler, Lisa T., Fatjó-Vilas, Mar, Favre, Pauline, Foley, Sonya F., Fullerton, Janice M., Glahn, David C., Goikolea, Jose M., Grotegerd, Dominik, Hahn, Tim, Henry, Chantal, Hibar, Derrek P., Houenou, Josselin, Howells, Fleur M., Jahanshad, Neda, Kaufmann, Tobias, Kenney, Joanne, Kircher, Tilo T.J., Krug, Axel, Lagerberg, Trine V., Lenroot, Rhoshel K., López-Jaramillo, Carlos, Machado-Vieira, Rodrigo, Malt, Ulrik F., McDonald, Colm, Mitchell, Philip B., van Haren, Neeltje E.M., and for the ENIGMA Bipolar Disorders Working Group

Published
2020

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