Search

Background: Paraoxonase‐1 (PON‐1) has been suggested as a marker of inflammation and oxidative stress in horses and could potentially be used for prognostication in horses with colitis. Objectives: Assessment of PON‐1 in horses with colitis and comparison of two methods. Methods: Serum PON‐1 was measured by two methods (paraoxon and p‐nitrophenyl acetate) in 161 horses with colitis and 57 controls. Follow‐up samples obtained during hospitalization were available from 106 horses with colitis. The two methods were compared. Results: Serum PON‐1 was significantly lower in horses with colitis than in healthy horses (P <.0001 for both methods) as well as in nonsurvivors compared with survivors (P =.0141 [paraoxon‐based method] and P <.0001 [p‐nitrophenyl acetate‐based method]), but with marked overlap between groups. PON‐1 activity did not change parallel to a change in inflammatory status in response to treatment when assessed at admission and in up to seven follow‐up samples. Admission PON‐1 activity could not reliably classify horses as survivors or nonsurvivors, with sensitivity and specificity ranging between 53.1% and 72.9%. Results from the two methods were comparable. Conclusions: Both methods reliably measured serum PON‐1 activity. Significant differences in PON‐1 activity were found between healthy horses and horses with colitis and between survivors and nonsurvivors. However, PON‐1 activity varied considerably within groups. Both the proposed reference intervals as well as alternative cutoff values resulted in suboptimal diagnostic and prognostic performance, and the use of serum PON‐1 in horses with colitis thus seems to add little to existing diagnostic and prognostic markers. [ABSTRACT FROM AUTHOR]

Copyright of Equine Veterinary Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

A clock and data recovery (CDR) circuit dedicated to satellite embedded high-speed data links is implemented in a 0.13 [micro]m CMOS technology. Its radiation hardening is obtained thanks to an innovative architecture based on an injection-locked oscillator (ILO) associated with a phase-alignment circuit. Its low single-event transient (SET) sensitivity is shown thanks to heavy-ion and laser testing. Index Terms--Clock and data recovery (CDR), CMOS technology, heavy-ion testing, high-speed data links, injection-locked oscillators (ILO), laser testing, radiation hardening by design, single-event transients (SET).