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13. Biodiversity Conservation and Drug Development in Suriname

Author

Kingston, D.G.I., primary, Gunatilaka, A.A.L., additional, Zhou, B.-N., additional, Abdel-Kader, M., additional, Berger, J., additional, Werff, H. van der, additional, Evans, R., additional, Famolare, L., additional, Mittermeier, R., additional, Malone, S., additional, and Wisse, J.H., additional

Published
2018
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14. Development of a Manometric Monitoring Method for Early Detection of Air Microbiological Contamination in the Bloodstream

Author

Agenor G. dos Santos-Neto, Malone S. Pinheiro, Monica C. dos Santos, Lumar L. Alves, Renata R. S. Poderoso, Juliana C. Cardoso, Patricia Severino, Eliana B. Souto, and Ricardo L. C. de Albuquerque-Junior

Subjects
atmospheric pathogens diagnosis, bloodstream infections, microorganisms, gram-negative bacteria, manometric method, Meteorology. Climatology, QC851-999
Abstract

Atmospheric air is a microbial habitat of pathogenic bioaerosols that may pose serious risks to humans. A commonly laboratory-based approach for the diagnosis of such infections in the bloodstream is the blood culture analysis. Its clinical relevance is attributed to the fact that these infections are characterized by high rates of morbidity and mortality, requiring the need for efficient methods for rapid diagnosis. For this reason, our study aimed to develop a method of manometric monitoring for the rapid detection of viable microorganisms in blood culture vials. A methodology was developed to detect pressure variation in intra-vials through a manometric instrument that was coupled to vials of blood culture containing culture broth that allowed microbial growth. This device allowed the early detection of microbial activity based on the production or use of intra-flask gases as a result of microbial metabolic activity. The analyzed variables were the pressure as a function of time, microbial species, and culture medium. The highest pressure found in the flasks without microorganisms was 40 mmHg between 2 and 6 h, and the lowest pressure was −42 mmHg between 21 and 24 h. The variation of the internal pressure in blood culture flasks according to different groups of microorganisms as a function of time demonstrated that the fermentative gram-negative bacilli and gram-positive cocci exhibited a significant increase in relation to their respective control groups (p < 0.001). The non-fermenting gram-negative bacilli showed expected results in relation to the pressure variation in which the production of negative pressures was noticed during the period of analysis, with a significant difference with respect to their control groups (p < 0.001). The developed methodology for the early detection of microorganisms responsible for bloodstream infection was demonstrated to be effective.

Published
2021
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17. PP154 [Quality and Safety » Safety]: DEVELOPMENT OF A QUANTITATIVE MEASURE (CRITCOM) TO ASSESS THE QUALITY OF INTERDISCIPLINARY COMMUNICATION AROUND PATIENT DETERIORATION IN VARIABLY RESOURCED HOSPITALS

Author

Rivera, J., primary, Malone, S., additional, Puerto Torres, M. F., additional, Prewitt, K., additional, Sakaan, F., additional, Al Zebin, Z., additional, Arias, A. V., additional, Bhattacharyya, P., additional, Gunasekera, S., additional, Johnson, S., additional, Kambugu, J., additional, Kaye, E. C., additional, Mandrell, B., additional, Mack, J., additional, Mcarthur, J., additional, Mendez, A., additional, Morrissey, L., additional, Sharara Chami, R., additional, Snaman, J., additional, Sniderman, E., additional, Luke, D., additional, Graetz, D., additional, and Agulnik, A., additional

Published
2022
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18. Sequencing of Androgen Deprivation Therapy of Short Duration with Radiotherapy for Non-Metastatic Prostate Cancer (SANDSTORM): A Pooled Analysis of 12 Randomized Trials

Author

Ma, T.M., primary, Sun, Y., additional, Romero, T., additional, Dearnaley, D., additional, Tree, A., additional, Bolla, M., additional, de Reijke, T.M., additional, Maingon, P., additional, Neven, A., additional, Zapatero, A., additional, Malone, S., additional, Roy, S., additional, Sydes, M., additional, Nabid, A., additional, Sandler, H.M., additional, Roach, M., additional, Pisansky, T.M., additional, Spratt, D.E., additional, and Kishan, A.U., additional

Published
2022
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19. Red Propolis and Its Dyslipidemic Regulator Formononetin: Evaluation of Antioxidant Activity and Gastroprotective Effects in Rat Model of Gastric Ulcer

Author

Marcio A. A. de Mendonça, Ana R. S. Ribeiro, Adriana K. de Lima, Gislaine B. Bezerra, Malone S. Pinheiro, Ricardo L. C. de Albuquerque-Júnior, Margarete Z. Gomes, Francine F. Padilha, Sara M. Thomazzi, Ettore Novellino, Antonello Santini, Patricia Severino, Eliana B. Souto, and Juliana C. Cardoso

Subjects
propolis, formononetin, dyslipidemia, gastric ulcer, rats, Nutrition. Foods and food supply, TX341-641
Abstract

Propolis has various pharmacological properties of clinical interest, and is also considered a functional food. In particular, hydroalcoholic extracts of red propolis (HERP), together with its isoflavonoid formononetin, have recognized antioxidant and anti-inflammatory properties, with known added value against dyslipidemia. In this study, we report the gastroprotective effects of HERP (50–500 mg/kg, p.o.) and formononetin (10 mg/kg, p.o.) in ethanol and non-steroidal anti-inflammatory drug-induced models of rat ulcer. The volume, pH, and total acidity were the evaluated gastric secretion parameters using the pylorus ligature model, together with the assessment of gastric mucus contents. The anti-Helicobacter pylori activities of HERP were evaluated using the agar-well diffusion method. In our experiments, HERP (250 and 500 mg/kg) and formononetin (10 mg/kg) reduced (p < 0.001) total lesion areas in the ethanol-induced rat ulcer model, and reduced (p < 0.05) ulcer indices in the indomethacin-induced rat ulcer model. Administration of HERP and formononetin to pylorus ligature models significantly decreased (p < 0.01) gastric secretion volumes and increased (p < 0.05) mucus production. We have also shown the antioxidant and anti-Helicobacter pylori activities of HERP. The obtained results indicate that HERP and formononetin are gastroprotective in acute ulcer models, suggesting a prominent role of formononetin in the effects of HERP.

Published
2020
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21. Clinical course, therapeutic responses and outcomes in relapsing MOG antibody-associated demyelination

Author

Ramanathan, Sudarshini, Mohammad, Shekeeb, Tantsis, Esther, Nguyen, Tina Kim, Merheb, Vera, Fung, Victor S C, White, Owen Bruce, Broadley, Simon, Lechner-Scott, Jeannette, Vucic, Steve, Henderson, Andrew P D, Barnett, Michael Harry, Reddel, Stephen W, Brilot, Fabienne, Dale, Russell C, Andrews, Pi, Barton, Jl, Burrow, Jnc, Butzkueven, H, Cairns, Ag, Calvert, S, Caruana, P, Chelakkadan, S, Clark, D, Fraser, Cl, Freeman, Jl, Gill, D, Grattan-smith, Pj, Gupta, S, Hardy, Ta, Kothur, K, Ling, Sr, Lopez, Ja, Malone, S, Marriott, Mp, Nosadini, M, O’grady, Gl, Orr, Cf, Ouvrier, R, Parratt, J, Patrick, E, Pilli, D, Riminton, Ds, Riney, K, Rodriguez-casero, V, Ryan, Mm, Scheffer, Ie, Shah, Uh, Shuey, N, Spooner, Cg, Subramanian, Gm, Tea, F, Thomas, T, Thompson, J, Troedson, C, Ware, Tl, Webster, Ri, Yiannikas, C, Yiu, Em, and Zou, A

Published
2018
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22. Women and Organisational Culture in SMEs

Author

Topic, M, Round, G, Carbery, C, Hunter, T, Young, M, Carr, R, Cockett, S, Eagles, S, Shaw, K, Fowler, M, Wajahat, A, Malone, S, Jekhine, D, and Griggs, A

Published
2022

23. The OM-85 Bacterial Lysate Inhibits SARS-CoV-2 Infection of Epithelial Cells by Downregulating SARS-CoV-2 Receptor Expression

Author

Pivniouk, V., primary, Pivniouk, O., additional, DeVries, A., additional, Uhrlaub, J., additional, Michael, A., additional, Pivniouk, D., additional, VanLinden, S., additional, Conway, M., additional, Hahn, S., additional, Malone, S., additional, Ezeh, P., additional, Churko, J., additional, Anderson, D., additional, Kraft, M., additional, Nikolich-Zugich, J., additional, and Vercelli, D., additional

Published
2022
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26. Impact of High DosE rAdioTherapy (HEAT) in Localized Prostate Cancer: An Individual Patient Data (IPD) Meta-Analysis of 15 Randomized Trials

Author

Kishan, A.U., primary, Romero, T., additional, Wang, X., additional, Pisansky, T.M., additional, Roach, M., additional, Bolla, M., additional, Steigler, A., additional, Denham, J.W., additional, Shipley, W.U., additional, Sandler, H.M., additional, Feng, F.Y., additional, Joseph, D.J., additional, Armstrong, J.G., additional, Dunne, M., additional, Malone, S., additional, Roy, S., additional, Zapatero, A., additional, Sun, Y., additional, Michalski, J.M., additional, and Spratt, D.E., additional

Published
2021
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27. Prognostic and Predictive Performance of Routine Clinicopathologic Variables in 10,535 Men Enrolled on Randomized Phase III Trials in Localized Prostate Cancer

Author

Dess, R.T., primary, Sun, Y., additional, Bolla, M., additional, Zapatero, A., additional, Malone, S., additional, Kishan, A.U., additional, Roy, S., additional, Jackson, W.C., additional, Lawton, C.A.F., additional, Sartor, O., additional, Nguyen, P.L., additional, Michalski, J.M., additional, Pisansky, T.M., additional, Roach, M., additional, Sandler, H.M., additional, Schipper, M., additional, Feng, F.Y., additional, and Spratt, D.E., additional

Published
2021
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38. Seismicity Remotely Triggered by the Magnitude 7.3 Landers, California, Earthquake

Author

Hill, D. P., Reasenberg, P. A., Michael, A., Arabaz, W. J., Beroza, G., Brumbaugh, D., Brune, J. N., Castro, R., Davis, S., dePolo, D., Ellsworth, W. L., Gomberg, J., Harmsen, S., House, L., Jackson, S. M., Johnston, M. J. S., Jones, L., Keller, R., Malone, S., Munguia, L., Nava, S., Pechmann, J. C., Sanford, A., Simpson, R. W., Smith, R. B., Stark, M., Stickney, M., Vidal, A., Walter, S., Wong, V., and Zollweg, J.

Published
1993

40. Cerebrospinal fluid liquid biopsy for detecting somatic mosaicism in brain

Author

Ye, Z, Chatterton, Z, Pflueger, J, Damiano, JA, McQuillan, L, Harvey, AS, Malone, S, Do, H, Maixner, W, Schneider, A, Nolan, B, Wood, M, Lee, WS, Gillies, G, Pope, K, Wilson, M, Lockhart, PJ, Dobrovic, A, Scheffer, IE, Bahlo, M, Leventer, RJ, Lister, R, Berkovic, SF, Hildebrand, MS, Ye, Z, Chatterton, Z, Pflueger, J, Damiano, JA, McQuillan, L, Harvey, AS, Malone, S, Do, H, Maixner, W, Schneider, A, Nolan, B, Wood, M, Lee, WS, Gillies, G, Pope, K, Wilson, M, Lockhart, PJ, Dobrovic, A, Scheffer, IE, Bahlo, M, Leventer, RJ, Lister, R, Berkovic, SF, and Hildebrand, MS

Abstract

Brain somatic mutations are an increasingly recognized cause of epilepsy, brain malformations and autism spectrum disorders and may be a hidden cause of other neurodevelopmental and neurodegenerative disorders. At present, brain mosaicism can be detected only in the rare situations of autopsy or brain biopsy. Liquid biopsy using cell-free DNA derived from cerebrospinal fluid has detected somatic mutations in malignant brain tumours. Here, we asked if cerebrospinal fluid liquid biopsy can be used to detect somatic mosaicism in non-malignant brain diseases. First, we reliably quantified cerebrospinal fluid cell-free DNA in 28 patients with focal epilepsy and 28 controls using droplet digital PCR. Then, in three patients we identified somatic mutations in cerebrospinal fluid: in one patient with subcortical band heterotopia the LIS1 p. Lys64* variant at 9.4% frequency; in a second patient with focal cortical dysplasia the TSC1 p. Phe581His*6 variant at 7.8% frequency; and in a third patient with ganglioglioma the BRAF p. Val600Glu variant at 3.2% frequency. To determine if cerebrospinal fluid cell-free DNA was brain-derived, whole-genome bisulphite sequencing was performed and brain-specific DNA methylation patterns were found to be significantly enriched (P = 0.03). Our proof of principle study shows that cerebrospinal fluid liquid biopsy is valuable in investigating mosaic neurological disorders where brain tissue is unavailable.

Published
2021

41. Cerebrospinal fluid liquid biopsy for detecting somatic mosaicism in brain (vol 3, fcaa235, 2021)

Author

Ye, Z, Chatterton, Z, Pflueger, J, Damiano, JA, McQuillan, L, Harvey, AS, Malone, S, Do, H, Maixner, W, Schneider, A, Nolan, B, Wood, M, Lee, WS, Gillies, G, Pope, K, Wilson, M, Lockhart, PJ, Dobrovic, A, Scheffer, IE, Bahlo, M, Leventer, RJ, Lister, R, Berkovic, SF, Hildebrand, MS, Ye, Z, Chatterton, Z, Pflueger, J, Damiano, JA, McQuillan, L, Harvey, AS, Malone, S, Do, H, Maixner, W, Schneider, A, Nolan, B, Wood, M, Lee, WS, Gillies, G, Pope, K, Wilson, M, Lockhart, PJ, Dobrovic, A, Scheffer, IE, Bahlo, M, Leventer, RJ, Lister, R, Berkovic, SF, and Hildebrand, MS

Abstract

[This corrects the article DOI: 10.1093/braincomms/fcaa235.][This corrects the article DOI: 10.1093/braincomms/fcaa235.].

Published
2021

42. The determinants of extreme commodity prices

Author

Kurlbayeva, K and Malone, S

Abstract

Fat-tailed commodity price innovations are well-documented in the literature and long recognized as disruptive for consumers and producers, yet little is known about what factors drive such extreme events. Utilizing a wide range of factors from the economics and finance literature and quantile regression techniques, we shed light on this issue. Our models explain more variation in extreme than in median price innovations. Common global financial and demand factors account for a greater proportion of extreme daily spot price variations than do commodity-specific factors such as basis and open interest. Financialization of commodity markets, via significant and increasing co-variation of extreme spot price innovations with US equity market and trade-weighted US dollar returns, appears to be a major driver of extreme events in the 2000-2009 period.

Published
2020

44. Synergies Among Environmental Science Research and Monitoring Networks: A Research Agenda

Author

Jones, J. A., primary, Groffman, P. M., additional, Blair, J., additional, Davis, F. W., additional, Dugan, H., additional, Euskirchen, E. E., additional, Frey, S. D., additional, Harms, T. K., additional, Hinckley, E., additional, Kosmala, M., additional, Loberg, S., additional, Malone, S., additional, Novick, K., additional, Record, S., additional, Rocha, A. V., additional, Ruddell, B. L., additional, Stanley, E. H., additional, Sturtevant, C., additional, Thorpe, A., additional, White, T., additional, Wieder, W. R., additional, Zhai, L., additional, and Zhu, K., additional

Published
2021
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45. Neuron-derived neurotrophic factor (NDNF) is mutated in patients with Congenital Hypogonadotropic Hypogonadism

Author

Messina, A., Pulli, K., Santini, S., Acierno, J., Känsäkoski, J., Cassatella, D., Xu, C., Casoni, F., Malone, S. A., Ternier, G., Conte, D., Sidis, Y., Tommiska, J., Vaaralahti, K., Dwyer, A., Gothilf, Y., Merlo, G. R., Santoni, F., Niederländer, N. J., Giacobini, P., Raivio, T., and Pitteloud, N

Subjects
Gonadotropin Kallmann Disease GnRH Animal Model of Disease Neurotrophic Factor
Published
2020

46. Clinical course, therapeutic responses and outcomes in relapsing MOG antibody-associated demyelination

Author

Ramanathan, S, Mohammad, S, Tantsis, E, Nguyen, Tk, Merheb, V, Fung, Vsc, White, Ob, Broadley, S, Lechner-Scott, J, Vucic, S, Henderson, Apd, Barnett, Mh, Reddel, Sw, Brilot, F, Dale, Rc, Australasian and New Zealand MOG Study Group Andrews, P, Barton, J, Burrow, J, Butzkueven, H, Cairns, A, Calvert, S, Caruana, P, Chelakkadan, S, Clark, D, Fraser, C, Freeman, J, Gill, D, Grattan-Smith, P, Gupta, S, Hardy, T, Kothur, K, Ling, S, Lopez, J, Malone, S, Marriott, M, Nosadini, M, O'Grady, G, Orr, C, Ouvrier, R, Parratt, J, Patrick, E, Pilli, D, Riminton, D, Riney, K, Rodriguez-Casero, V, Ryan, M, Scheffer, I, Shah, U, Shuey, N, Spooner, C, Subramanian, G, Tea, F, Thomas, T, Thompson, J, Troedson, C, Ware, T, Webster, R, Yiannikas, C, Yiu, E, and Zou, A.

Subjects
Male, 0301 basic medicine, Journal Club, medicine.medical_treatment, Demyelinating Autoimmune Diseases, CNS, Cohort Studies, 0302 clinical medicine, Prednisone, Child, 10. No inequality, MOG antibody, demyelination, treatment, treatment, biology, Encephalomyelitis, Acute Disseminated, Neuromyelitis Optica, Brain, Immunoglobulins, Intravenous, Middle Aged, Magnetic Resonance Imaging, 3. Good health, Psychiatry and Mental health, Child, Preschool, Acute disseminated encephalomyelitis, Cohort, Female, demyelination, Immunotherapy, Antibody, Rituximab, Immunosuppressive Agents, medicine.drug, MOG antibody, Adult, medicine.medical_specialty, Optic Neuritis, Adolescent, Myelitis, Transverse, Myelin oligodendrocyte glycoprotein, Young Adult, 03 medical and health sciences, Internal medicine, medicine, Humans, Immunologic Factors, Optic neuritis, Aged, Autoantibodies, Expanded Disability Status Scale, business.industry, Infant, Mycophenolic Acid, medicine.disease, 030104 developmental biology, Immunology, biology.protein, Myelin-Oligodendrocyte Glycoprotein, Surgery, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

ObjectiveWe characterised the clinical course, treatment and outcomes in 59 patients with relapsing myelin oligodendrocyte glycoprotein (MOG) antibody-associated demyelination.MethodsWe evaluated clinical phenotypes, annualised relapse rates (ARR) prior and on immunotherapy and Expanded Disability Status Scale (EDSS), in 218 demyelinating episodes from 33 paediatric and 26 adult patients.ResultsThe most common initial presentation in the cohort was optic neuritis (ON) in 54% (bilateral (BON) 32%, unilateral (UON) 22%), followed by acute disseminated encephalomyelitis (ADEM) (20%), which occurred exclusively in children. ON was the dominant phenotype (UON 35%, BON 19%) of all clinical episodes. 109/226 (48%) MRIs had no brain lesions. Patients were steroid responsive, but 70% of episodes treated with oral prednisone relapsed, particularly at doses ConclusionRelapsing MOG antibody-associated demyelination is strongly associated with ON across all age groups and ADEM in children. Patients are highly responsive to steroids, but vulnerable to relapse on steroid reduction and cessation.

Published
2017

48. Short-Term Adjuvant versus Neoadjuvant Hormone Therapy in Localized Prostate Cancer: A Pooled Individual Patient Analysis of Two Randomized Phase 3 Trials

Author

Spratt, D.E., primary, Malone, S., additional, Roy, S., additional, Grimes, S., additional, Eapen, L., additional, Morgan, S.C., additional, Malone, J., additional, Craig, J., additional, Dess, R.T., additional, Jackson, W.C., additional, Schipper, M., additional, Michalski, J.M., additional, Lee, W.R., additional, Pisansky, T.M., additional, Feng, F.Y., additional, Shipley, W.U., additional, Sandler, H.M., additional, Roach, M., additional, Sun, Y., additional, and Lawton, C.A.F., additional

Published
2020
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49. Effect Of Hormone Therapy Within Risk Groups Defined By Generalized Competing Event Model: Ancillary Analysis Of NRG Oncology’s RTOG 9408

Author

Mell, L.K., primary, Pugh, S., additional, Jones, C.U., additional, Nelson, T.J., additional, Morginstin, M., additional, Gore, E.M., additional, Zakeri, K., additional, Bahary, J.P., additional, Souhami, L., additional, Michalski, J.M., additional, Hartford, A.C., additional, Mishra, M.V., additional, Roach, M., additional, Parliament, M.B., additional, Choi, K.N., additional, Pisansky, T.M., additional, Husain, S.M., additional, Malone, S., additional, Horwitz, E.M., additional, and Feng, F.Y., additional

Published
2020
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50. Impact Of Sequencing Of Androgen Receptor-Signaling Inhibition (ARSI) And Ionizing Radiotherapy (RT) In Prostate Cancer: Importance Of Homologous Recombination (HR) Disruption

Author

Allen, S.G., primary, Zhang, C., additional, Speers, C., additional, Malone, S., additional, Roy, S., additional, Dess, R.T., additional, Jackson, W.C., additional, Wahl, D.R., additional, Mehra, R., additional, Alumkal, J., additional, Sandler, H.M., additional, Roach, M., additional, Sun, Y., additional, Lawton, C.A.F., additional, Feng, F.Y., additional, Chinnaiyan, A., additional, and Spratt, D.E., additional

Published
2020
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