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15 results on '"Maloku, Ekrem"'

3. Clinical utility of whole-genome DNA methylation profiling as a primary molecular diagnostic assay for central nervous system tumors—A prospective study and guidelines for clinical testing

Author

Galbraith, Kristyn, primary, Vasudevaraja, Varshini, additional, Serrano, Jonathan, additional, Shen, Guomiao, additional, Tran, Ivy, additional, Abdallat, Nancy, additional, Wen, Mandisa, additional, Patel, Seema, additional, Movahed-Ezazi, Misha, additional, Faustin, Arline, additional, Spino-Keeton, Marissa, additional, Roberts, Leah Geiser, additional, Maloku, Ekrem, additional, Drexler, Steven A, additional, Liechty, Benjamin L, additional, Pisapia, David, additional, Krasnozhen-Ratush, Olga, additional, Rosenblum, Marc, additional, Shroff, Seema, additional, Boué, Daniel R, additional, Davidson, Christian, additional, Mao, Qinwen, additional, Suchi, Mariko, additional, North, Paula, additional, Hopp, Amanda, additional, Segura, Annette, additional, Jarzembowski, Jason A, additional, Parsons, Lauren, additional, Johnson, Mahlon D, additional, Mobley, Bret, additional, Samore, Wesley, additional, McGuone, Declan, additional, Gopal, Pallavi P, additional, Canoll, Peter D, additional, Horbinski, Craig, additional, Fullmer, Joseph M, additional, Farooqui, Midhat S, additional, Gokden, Murat, additional, Wadhwani, Nitin R, additional, Richardson, Timothy E, additional, Umphlett, Melissa, additional, Tsankova, Nadejda M, additional, DeWitt, John C, additional, Sen, Chandra, additional, Placantonakis, Dimitris G, additional, Pacione, Donato, additional, Wisoff, Jeffrey H, additional, Teresa Hidalgo, Eveline, additional, Harter, David, additional, William, Christopher M, additional, Cordova, Christine, additional, Kurz, Sylvia C, additional, Barbaro, Marissa, additional, Orringer, Daniel A, additional, Karajannis, Matthias A, additional, Sulman, Erik P, additional, Gardner, Sharon L, additional, Zagzag, David, additional, Tsirigos, Aristotelis, additional, Allen, Jeffrey C, additional, Golfinos, John G, additional, and Snuderl, Matija, additional

Published
2023
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6. Phase 0 Clinical Trial of Everolimus in Patients with Vestibular Schwannoma or Meningioma

Author

Karajannis, Matthias A., primary, Mauguen, Audrey, additional, Maloku, Ekrem, additional, Xu, Qingwen, additional, Dunbar, Erin M., additional, Plotkin, Scott R., additional, Yaffee, Anna, additional, Wang, Shiyang, additional, Roland, J. Thomas, additional, Sen, Chandranath, additional, Placantonakis, Dimitris G., additional, Golfinos, John G., additional, Allen, Jeffrey C., additional, Vitanza, Nicholas A., additional, Chiriboga, Luis A., additional, Schneider, Robert J., additional, Deng, Jingjing, additional, Neubert, Thomas A., additional, Goldberg, Judith D., additional, Zagzag, David, additional, Giancotti, Filippo G., additional, and Blakeley, Jaishri O., additional

Published
2021
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15. Selective α4β2 Nicotinic Acetylcholine Receptor Agonists Target Epigenetic Mechanisms in Cortical GABAergic Neurons.

Author

Maloku, Ekrem, Kadriu, Bashkim, Zhubi, Adrian, Dong, Erbo, Pibiri, Fabio, Satta, Rosalba, and Guidotti, Alessandro

Subjects
*NICOTINE, *ACETYLCHOLINE, *EPIGENESIS, *NEURONS, *SCHIZOPHRENIA, *METHYLTRANSFERASES, *LABORATORY mice, *PSYCHOLOGY
Abstract

Nicotine improves cognitive performance and attention in both experimental animals and in human subjects, including patients affected by neuropsychiatric disorders. However, the specific molecular mechanisms underlying nicotine-induced behavioral changes remain unclear. We have recently shown in mice that repeated injections of nicotine, which achieve plasma concentrations comparable to those reported in high cigarette smokers, result in an epigenetically induced increase of glutamic acid decarboxylase 67 (GAD67) expression. Here we explored the impact of synthetic α4β2 and α7 nAChR agonists on GABAergic epigenetic parameters. Varenicline (VAR), a high-affinity partial agonist at α4β2 and a lower affinity full agonist at α7 neuronal nAChR, injected in doses of 1-5 mg/kg/s.c. twice daily for 5 days, elicited a 30-40% decrease of cortical DNA methyltransferase (DNMT)1 mRNA and an increased expression of GAD67 mRNA and protein. This upregulation of GAD67 was abolished by the nAChR antagonist mecamylamine. Furthermore, the level of MeCP2 binding to GAD67 promoters was significantly reduced following VAR administration. This effect was abolished when VAR was administered with mecamylamine. Similar effects on cortical DNMT1 and GAD67 expression were obtained after administration of A-85380, an agonist that binds to α4β2 but has negligible affinity for α3β4 or α7 subtypes containing nAChR. In contrast, PNU-282987, an agonist of the homomeric α7 nAChR, failed to decrease cortical DNMT1 mRNA or to induce GAD67 expression. The present study suggests that the α4β2 nAChR agonists may be better suited to control the epigenetic alterations of GABAergic neurons in schizophrenia than the α7 nAChR agonists. [ABSTRACT FROM AUTHOR]

Published
2011
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