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297 results on '"Mallipeddi R"'

5. Constraint Handling in Transmission Network Expansion Planning

Author

Mallipeddi, R., Verma, Ashu, Suganthan, P. N., Panigrahi, B. K., Bijwe, P. R., Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Panigrahi, Bijaya Ketan, editor, Das, Swagatam, editor, Suganthan, Ponnuthurai Nagaratnam, editor, and Dash, Subhransu Sekhar, editor

Published
2010
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38. Spatial constraints govern competition of mutant clones in human epidermis

Author

Lynch, M. D., Lynch, C. N. S., Craythorne, E., Liakath-Ali, K., Mallipeddi, R., Barker, J. N., and Watt, F. M.

Subjects
Adult, Aged, 80 and over, Stochastic Processes, Skin Neoplasms, Cell Survival, Stem Cells, Science, DNA Mutational Analysis, Genetic Drift, Middle Aged, Models, Theoretical, Article, Clone Cells, Clonal Evolution, Epidermal Cells, Mutation, Journal Article, Humans, Cell Lineage, lcsh:Q, lcsh:Science, Alleles, Aged, Gene Library
Abstract

Deep sequencing can detect somatic DNA mutations in tissues permitting inference of clonal relationships. This has been applied to human epidermis, where sun exposure leads to the accumulation of mutations and an increased risk of skin cancer. However, previous studies have yielded conflicting conclusions about the relative importance of positive selection and neutral drift in clonal evolution. Here, we sequenced larger areas of skin than previously, focusing on cancer-prone skin spanning five decades of life. The mutant clones identified were too large to be accounted for solely by neutral drift. Rather, using mathematical modelling and computational lattice-based simulations, we show that observed clone size distributions can be explained by a combination of neutral drift and stochastic nucleation of mutations at the boundary of expanding mutant clones that have a competitive advantage. These findings demonstrate that spatial context and cell competition cooperate to determine the fate of a mutant stem cell., Deep sequencing technologies allow for the investigation of clonal evolution in human cancers. Here the authors, combining sequencing data from human skin with mathematical modelling and simulations, suggest that the spatial context of a mutation with respect to other mutant clones may lead to differential clonal evolution.

Published
2017
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39. The Adverse Effects of Topical Photodynamic Therapy: a consensus review

Author

Ibbotson, S. H., Wong, T, Morton, Colin, Collier, N J, Haylett, Ann, McKenna, K. E., Mallipeddi, R, Moseley, H, Rhodes, Lesley, Suekeran, Don, Ward, KA, Mohd Mustapa, M Firouz, and Exton, L

Abstract

BackgroundTopical photodynamic therapy (PDT) is widely used to treat superficial nonmelanoma skin cancer and dysplasia, and is generally well tolerated. However, as with all treatments, adverse effects may occur and awareness may facilitate approaches to prevention and management.ObjectivesTo review the available evidence relating to the adverse effects of topical PDT, to help inform recommendations in updated clinical guidelines produced by the British Association of Dermatologists and British Photodermatology Group, and the efficacy of preventative and therapeutic approaches.MethodsThis review summarizes the published evidence related to the adverse effects of topical PDT and attempts to interpret this evidence in the context of patient risk and management.ResultsPain and discomfort during PDT are acute adverse effects, which can be minimized through the use of modified and low‐irradiance PDT regimens and do not therefore usually limit successful treatment delivery. Other adverse effects include the risk of contact allergy to photosensitizer prodrugs, although this is rare but should be kept in mind, particularly for patients who have received multiple PDT treatments to larger areas. There are no other significant documented longer‐term risks and, to date, no evidence of cumulative toxicity or photocarcinogenic risk.ConclusionsTopical PDT is usually well tolerated, reinforcing the utility of this important therapeutic option in dermatology practice. The main acute adverse effect of pain can typically be minimized through preventative approaches of modified PDT regimens. Other adverse effects are uncommon and generally do not limit treatment delivery.

Published
2019
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48. British Association of Dermatologists guidelines for the management of adults with basal cell carcinoma 2021*.

Author

Nasr, I., McGrath, E.J., Harwood, C.A., Botting, J., Buckley, P., Budny, P.G., Fairbrother, P., Fife, K., Gupta, G., Hashme, M., Hoey, S., Lear, J.T., Mallipeddi, R., Mallon, E., Motley, R.J., Newlands, C., Newman, J., Pynn, E.V., Shroff, N., and Slater, D.N.

Subjects
BASAL cell carcinoma, ADULTS, DERMATOLOGISTS
Abstract

Linked Comment:M.D. Moncrieff and J.P. Nobes. Br J Dermatol 2021; 185:877. Plain language summary available online [ABSTRACT FROM AUTHOR]

Published
2021
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