7 results on '"Mallick, Nadeem H."'
Search Results
2. Association of the PHACTR1/EDN1 Genetic Locus With Spontaneous Coronary Artery Dissection
- Author
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Adlam, David, primary, Olson, Timothy M., additional, Combaret, Nicolas, additional, Kovacic, Jason C., additional, Iismaa, Siiri E., additional, Al-Hussaini, Abtehale, additional, O'Byrne, Megan M., additional, Bouajila, Sara, additional, Georges, Adrien, additional, Mishra, Ketan, additional, Braund, Peter S., additional, d’Escamard, Valentina, additional, Huang, Siying, additional, Margaritis, Marios, additional, Nelson, Christopher P., additional, de Andrade, Mariza, additional, Kadian-Dodov, Daniella, additional, Welch, Catherine A., additional, Mazurkiewicz, Stephani, additional, Jeunemaitre, Xavier, additional, Wong, Claire Mei Yi, additional, Giannoulatou, Eleni, additional, Sweeting, Michael, additional, Muller, David, additional, Wood, Alice, additional, McGrath-Cadell, Lucy, additional, Fatkin, Diane, additional, Dunwoodie, Sally L., additional, Harvey, Richard, additional, Holloway, Cameron, additional, Empana, Jean-Philippe, additional, Jouven, Xavier, additional, Olin, Jeffrey W., additional, Gulati, Rajiv, additional, Tweet, Marysia S., additional, Hayes, Sharonne N., additional, Samani, Nilesh J., additional, Graham, Robert M., additional, Motreff, Pascal, additional, Bouatia-Naji, Nabila, additional, Belle, Loïc, additional, Dupouy, Patrick, additional, Barnay, Pierre, additional, Meneveau, Nicolas, additional, Gilard, Martine, additional, Rioufol, Gilles, additional, Range, Grégoire, additional, Brunel, Philippe, additional, Delarche, Nicolas, additional, Filippi, Emmanuelle, additional, Le Bivic, Louis, additional, Harbaoui, Brahim, additional, Benamer, Hakim, additional, Cayla, Guillaume, additional, Varenne, Olivier, additional, Manzo-Silberman, Stephane Peggy, additional, Silvain, Johanne, additional, Spaulding, Christian, additional, Caussin, Christophe, additional, Gerbaud, Edouard, additional, Valy, Yann, additional, Koning, René, additional, Lhermusier, Thibault, additional, Champin, Stanislas, additional, Salengro, Emmanuel, additional, Fluttaz, Arnaud, additional, Zabalawi, Amer, additional, Cottin, Yves, additional, Teiger, Emmanuel, additional, Saint-Etienne, Christophe, additional, Ducrocq, Grégory, additional, Marliere, Stéphanie, additional, Boiffard, Emmanuel, additional, Aubry, Pierre, additional, Georges, Jean Louis, additional, Bresson, Didier, additional, De Poli, Fabien, additional, Karrillon, Gaëtan, additional, Roule, Vincent, additional, Bali, Laurent, additional, Valla, Mathieu, additional, Gerbay, Antoine, additional, Houpe, David, additional, Dubreuil, Olivier, additional, Monnier, Arsène, additional, Mayaud, Norbert, additional, Manchuelle, Aurélie, additional, Commeau, Philippe, additional, Bedossa, Marc, additional, Nikpay, Majid, additional, Goel, Anuj, additional, Won, Hong-Hee, additional, Hall, Leanne M., additional, Willenborg, Christina, additional, Kanoni, Stavroula, additional, Saleheen, Danish, additional, Kyriakou, Theodosios, additional, Hopewell, Jemma C., additional, Webb, Thomas R., additional, Zeng, Lingyao, additional, Dehghan, Abbas, additional, Alver, Maris, additional, Armasu, Sebastian M., additional, Auro, Kirsi, additional, Bjonnes, Andrew, additional, Chasman, Daniel I., additional, Chen, Shufeng, additional, Ford, Ian, additional, Franceschini, Nora, additional, Gieger, Christian, additional, Grace, Christopher, additional, Gustafsson, Stefan, additional, Huang, Jie, additional, Hwang, Shih-Jen, additional, Kim, Yun Kyoung, additional, Kleber, Marcus E., additional, Lau, King Wai, additional, Lu, Xiangfeng, additional, Lu, Yingchang, additional, Lyytikäinen, Leo P., additional, Mihailov, Evelin, additional, Morrison, Alanna, additional, Pervjakova, Natalia, additional, Qu, Liming, additional, Rose, Lynda M., additional, Salfati, Elias, additional, Saxena, Richa, additional, Scholz, Markus, additional, Smith, Albert V., additional, Tikkanen, Emmi, additional, Uitterlinden, Andre, additional, Yang, Xueli, additional, Zhang, Weihua, additional, Zhao, Wei, additional, de Vries, Paul S., additional, van Zuydam, Natalie R., additional, Anand, Sonia S., additional, Bertram, Lars, additional, Beutner, Frank, additional, Dedoussis, George, additional, Frossard, Philippe, additional, Gauguier, Dominique, additional, Goodall, Alison H., additional, Gottesman, Omri, additional, Haber, Marc, additional, Han, Bok-Ghee, additional, Huang, Jianfeng, additional, Jalilzadeh, Shapour, additional, Kessler, Thorsten, additional, König, Inke R., additional, Lannfelt, Lars, additional, Lieb, Wolfgang, additional, Lind, Lars, additional, Lindgren, Cecilia M., additional, Lokki, Maisa, additional, Magnusson, Patrik K., additional, Mallick, Nadeem H., additional, Mehra, Narinder, additional, Meitinger, Thomas, additional, Memon, Fazal-ur-Rehman, additional, Morris, Andrew P., additional, Nieminen, Markku S., additional, Pedersen, Nancy L., additional, Peters, Annette, additional, Rallidis, Loukianos S., additional, Rasheed, Asif, additional, Samuel, Maria, additional, Shah, Svati H., additional, Sinisalo, Juha, additional, Stirrups, Kathleen E., additional, Trompet, Stella, additional, Wang, Laiyuan, additional, Zaman, Khan S., additional, Ardissino, Diego, additional, Boerwinkle, Eric, additional, Borecki, Ingrid B., additional, Bottinger, Erwin P., additional, Buring, Julie E., additional, Chambers, John C., additional, Collins, Rory, additional, Cupples, L Adrienne, additional, Danesh, John, additional, Demuth, Ilja, additional, Elosua, Roberto, additional, Epstein, Stephen E., additional, Esko, Tõnu, additional, Feitosa, Mary F., additional, Franco, Oscar H., additional, Franzosi, Maria Grazia, additional, Granger, Christopher B., additional, Gu, Dongfeng, additional, Gudnason, Vilmundur, additional, Hall, Alistair S., additional, Hamsten, Anders, additional, Harris, Tamara B., additional, Hazen, Stanley L., additional, Hengstenberg, Christian, additional, Hofman, Albert, additional, Ingelsson, Erik, additional, Iribarren, Carlos, additional, Jukema, J Wouter, additional, Karhunen, Pekka J., additional, Kim, Bong-Jo, additional, Kooner, Jaspal S., additional, Kullo, Iftikhar J., additional, Lehtimäki, Terho, additional, Loos, Ruth J., additional, Melander, Olle, additional, Metspalu, Andres, additional, März, Winfried, additional, Palmer, Colin N., additional, Perola, Markus, additional, Quertermous, Thomas, additional, Rader, Daniel J., additional, Ridker, Paul M., additional, Ripatti, Samuli, additional, Roberts, Robert, additional, Salomaa, Veikko, additional, Sanghera, Dharambir K., additional, Schwartz, Stephen M., additional, Seedorf, Udo, additional, Stewart, Alexandre F., additional, Stott, David J., additional, Thiery, Joachim, additional, Zalloua, Pierre A., additional, O'Donnell, Christopher J., additional, Reilly, Muredach P., additional, Assimes, Themistocles L., additional, Thompson, John R., additional, Erdmann, Jeanette, additional, Clarke, Robert, additional, Watkins, Hugh, additional, Kathiresan, Sekar, additional, McPherson, Ruth, additional, Deloukas, Panos, additional, Schunkert, Heribert, additional, and Farrall, Martin, additional
- Published
- 2019
- Full Text
- View/download PDF
3. A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease
- Author
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Nikpay, Majid, Goel, Anuj, Won, Hong-Hee, Hall, Leanne M., Willenborg, Christina, Kanoni, Stavroula, Saleheen, Danish, Kyriakou, Theodosios, Nelson, Christopher P., Hopewell, Jemma C., Webb, Thomas R., Zeng, Lingyao, Dehghan, Abbas, Alver, Maris, Armasu, Sebastian M., Auro, Kirsi, Bjonnes, Andrew, Chasman, Daniel I., Chen, Shufeng, Ford, Ian, Franceschini, Nora, Gieger, Christian, Grace, Christopher, Gustafsson, Stefan, Huang, Jie, Hwang, Shih-Jen, Kim, Yun Kyoung, Kleber, Marcus E., Lau, King Wai, Lu, Xiangfeng, Lu, Yingchang, Lyytikainen, Leo-Pekka, Mihailov, Evelin, Morrison, Alanna C., Pervjakova, Natalia, Qu, Liming, Rose, Lynda M., Salfati, Elias, Saxena, Richa, Scholz, Markus, Smith, Albert V., Tikkanen, Emmi, Uitterlinden, Andre, Yang, Xueli, Zhang, Weihua, Zhao, Wei, de Andrade, Mariza, de Vries, Paul S., van Zuydam, Natalie R., Anand, Sonia S., Bertram, Lars, Beutner, Frank, Dedoussis, George, Frossard, Philippe, Gauguier, Dominique, Goodall, Alison H., Gottesman, Omri, Haber, Marc, Han, Bok-Ghee, Huang, Jianfeng, Jalilzadeh, Shapour, Kessler, Thorsten, Koenig, Inke R., Lannfelt, Lars, Lieb, Wolfgang, Lind, Lars, Lindgren, Cecilia M., Lokki, Marja-Liisa, Magnusson, Patrik K., Mallick, Nadeem H., Mehra, Narinder, Meitinger, Thomas, Memon, Fazal-ur-Rehman, Morris, Andrew P., Nieminen, Markku S., Pedersen, Nancy L., Peters, Annette, Rallidis, Loukianos S., Rasheed, Asif, Samuel, Maria, Shah, Svati H., Sinisalo, Juha, Stirrups, Kathleen E., Trompet, Stella, Wang, Laiyuan, Zaman, Khan S., Ardissino, Diego, Boerwinkle, Eric, Borecki, Ingrid B., Bottinger, Erwin P., Buring, Julie E., Chambers, John C., Collins, Rory, Cupples, L. Adrienne, Danesh, John, Demuth, Ilja, Elosua, Roberto, Epstein, Stephen E., Esko, Tonu, Feitosa, Mary F., Franco, Oscar H., Franzosi, Maria Grazia, Granger, Christopher B., Gu, Dongfeng, Gudnason, Vilmundur, Hall, Alistair S., Hamsten, Anders, Harris, Tamara B., Hazen, Stanley L., Hengstenberg, Christian, Hofman, Albert, Ingelsson, Erik, Iribarren, Carlos, Jukema, J. Wouter, Karhunen, Pekka J., Kim, Bong-Jo, Kooner, Jaspal S., Kullo, Iftikhar J., Lehtimaki, Terho, Loos, Ruth J. F., Melander, Olle, Metspalu, Andres, Maerz, Winfried, Palmer, Colin N., Perola, Markus, Quertermous, Thomas, Rader, Daniel J., Ridker, Paul M., Ripatti, Samuli, Roberts, Robert, Salomaa, Veikko, Sanghera, Dharambir K., Schwartz, Stephen M., Seedorf, Udo, Stewart, Alexandre F., Stott, David J., Thiery, Joachim, Zalloua, Pierre A., O'Donnell, Christopher J., Reilly, Muredach P., Assimes, Themistocles L., Thompson, John R., Erdmann, Jeanette, Clarke, Robert, Watkins, Hugh, Kathiresan, Sekar, McPherson, Ruth, Deloukas, Panos, Schunkert, Heribert, Samani, Nilesh J., Farrall, Martin, Nikpay, Majid, Goel, Anuj, Won, Hong-Hee, Hall, Leanne M., Willenborg, Christina, Kanoni, Stavroula, Saleheen, Danish, Kyriakou, Theodosios, Nelson, Christopher P., Hopewell, Jemma C., Webb, Thomas R., Zeng, Lingyao, Dehghan, Abbas, Alver, Maris, Armasu, Sebastian M., Auro, Kirsi, Bjonnes, Andrew, Chasman, Daniel I., Chen, Shufeng, Ford, Ian, Franceschini, Nora, Gieger, Christian, Grace, Christopher, Gustafsson, Stefan, Huang, Jie, Hwang, Shih-Jen, Kim, Yun Kyoung, Kleber, Marcus E., Lau, King Wai, Lu, Xiangfeng, Lu, Yingchang, Lyytikainen, Leo-Pekka, Mihailov, Evelin, Morrison, Alanna C., Pervjakova, Natalia, Qu, Liming, Rose, Lynda M., Salfati, Elias, Saxena, Richa, Scholz, Markus, Smith, Albert V., Tikkanen, Emmi, Uitterlinden, Andre, Yang, Xueli, Zhang, Weihua, Zhao, Wei, de Andrade, Mariza, de Vries, Paul S., van Zuydam, Natalie R., Anand, Sonia S., Bertram, Lars, Beutner, Frank, Dedoussis, George, Frossard, Philippe, Gauguier, Dominique, Goodall, Alison H., Gottesman, Omri, Haber, Marc, Han, Bok-Ghee, Huang, Jianfeng, Jalilzadeh, Shapour, Kessler, Thorsten, Koenig, Inke R., Lannfelt, Lars, Lieb, Wolfgang, Lind, Lars, Lindgren, Cecilia M., Lokki, Marja-Liisa, Magnusson, Patrik K., Mallick, Nadeem H., Mehra, Narinder, Meitinger, Thomas, Memon, Fazal-ur-Rehman, Morris, Andrew P., Nieminen, Markku S., Pedersen, Nancy L., Peters, Annette, Rallidis, Loukianos S., Rasheed, Asif, Samuel, Maria, Shah, Svati H., Sinisalo, Juha, Stirrups, Kathleen E., Trompet, Stella, Wang, Laiyuan, Zaman, Khan S., Ardissino, Diego, Boerwinkle, Eric, Borecki, Ingrid B., Bottinger, Erwin P., Buring, Julie E., Chambers, John C., Collins, Rory, Cupples, L. Adrienne, Danesh, John, Demuth, Ilja, Elosua, Roberto, Epstein, Stephen E., Esko, Tonu, Feitosa, Mary F., Franco, Oscar H., Franzosi, Maria Grazia, Granger, Christopher B., Gu, Dongfeng, Gudnason, Vilmundur, Hall, Alistair S., Hamsten, Anders, Harris, Tamara B., Hazen, Stanley L., Hengstenberg, Christian, Hofman, Albert, Ingelsson, Erik, Iribarren, Carlos, Jukema, J. Wouter, Karhunen, Pekka J., Kim, Bong-Jo, Kooner, Jaspal S., Kullo, Iftikhar J., Lehtimaki, Terho, Loos, Ruth J. F., Melander, Olle, Metspalu, Andres, Maerz, Winfried, Palmer, Colin N., Perola, Markus, Quertermous, Thomas, Rader, Daniel J., Ridker, Paul M., Ripatti, Samuli, Roberts, Robert, Salomaa, Veikko, Sanghera, Dharambir K., Schwartz, Stephen M., Seedorf, Udo, Stewart, Alexandre F., Stott, David J., Thiery, Joachim, Zalloua, Pierre A., O'Donnell, Christopher J., Reilly, Muredach P., Assimes, Themistocles L., Thompson, John R., Erdmann, Jeanette, Clarke, Robert, Watkins, Hugh, Kathiresan, Sekar, McPherson, Ruth, Deloukas, Panos, Schunkert, Heribert, Samani, Nilesh J., and Farrall, Martin
- Abstract
Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is largely based on genome-wide association study (GWAS) analysis of common SNPs. Leveraging phased haplotypes from the 1000 Genomes Project, we report a GWAS meta-analysis of similar to 185,000 CAD cases and controls, interrogating 6.7 million common (minor allele frequency (MAF) > 0.05) and 2.7 million low-frequency (0.005 < MAF < 0.05) variants. In addition to confirming most known CAD-associated loci, we identified ten new loci (eight additive and two recessive) that contain candidate causal genes newly implicating biological processes in vessel walls. We observed intralocus allelic heterogeneity but little evidence of low-frequency variants with larger effects and no evidence of synthetic association. Our analysis provides a comprehensive survey of the fine genetic architecture of CAD, showing that genetic susceptibility to this common disease is largely determined by common SNPs of small effect size.
- Published
- 2015
- Full Text
- View/download PDF
4. Human knockouts in a cohort with a high rate of consanguinity
- Author
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Saleheen, Danesh, primary, Natarajan, Pradeep, additional, Zhao, Wei, additional, Rasheed, Asif, additional, Khetarpal, Sumeet, additional, Won, Hong-Hee, additional, Karczewski, Konrad J, additional, ODonnell-Luria, Anne H, additional, Samocha, Kaitlin E, additional, Gupta, Namrata, additional, Zaidi, Mozzam, additional, Samuel, Maria, additional, Imran, Atif, additional, Abbas, Shahid, additional, Majeed, Faisal, additional, Ishaq, Madiha, additional, Akhtar, Saba, additional, Trindade, Kevin, additional, Mucksavage, Megan, additional, Qamar, Nadeem, additional, Zaman, Khan S, additional, Yaqoob, Zia, additional, Saghir, Tahir, additional, Rizvi, Syed NH, additional, Memon, Anis, additional, Mallick, Nadeem H, additional, Ishaq, Mohammad, additional, Rasheed, Syed Z, additional, Memon, Fazal ur Rehman, additional, Mahmood, Khalid, additional, Ahmed, Naveeduddin, additional, Do, Ron, additional, MacArthur, Daniel G, additional, Gabriel, Stacey, additional, Lander, Eric S, additional, Daly, Mark J, additional, Frossard, Philippe, additional, Danesh, John, additional, Rader, Daniel J, additional, and Kathiresan, Sekar, additional
- Published
- 2015
- Full Text
- View/download PDF
5. PM255 Achievement of Target Blood Pressure In Patients on Antihypertensive Therapy In Pakistan: Results of Action Registry
- Author
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Hanif, Bashir, primary, Rehman, Aziz U., additional, Mallick, Nadeem H., additional, Ullah, Saleem, additional, and Shah, Fayaz H., additional
- Published
- 2014
- Full Text
- View/download PDF
6. A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease
- Author
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Peden, John F., Hopewell, Jemma C., Saleheen, Danish, Chambers, John C., Hager, Jorg, Soranzo, Nicole, Collins, Rory, Danesh, John, Elliott, Paul, Farrall, Martin, Stirrups, Kathy, Zhang, Weihua, Hamsten, Anders, Parish, Sarah, Lathrop, Mark, Watkins, Hugh, Clarke, Robert, Deloukas, Panos, Kooner, Jaspal S., Goel, Anuj, Ongen, Halit, Strawbridge, Rona J., Heath, Simon, Mälarstig, Anders, Helgadottir, Anna, Öhrvik, John, Murtaza, Muhammed, Potter, Simon, Hunt, Sarah E., Delepine, Marc, Jalilzadeh, Shapour, Axelsson, Tomas, Syvänen, Ann-Christine, Gwilliam, Rhian, Bumpstead, Suzannah, Gray, Emma, Edkins, Sarah, Folkersen, Lasse, Kyriakou, Theodosios, Franco-Cereceda, Anders, Gabrielsen, Anders, Seedorf, Udo, Eriksson, Per, Offer, Alison, Bowman, Louise, Sleight, Peter, Armitage, Jane, Peto, Richard, Abecasis, Goncalo, Ahmed, Nabeel, Caulfield, Mark, Donnelly, Peter, Froguel, Philippe, Kooner, Angad S., McCarthy, Mark I., Samani, Nilesh J., Scott, James, Sehmi, Joban, Silveira, Angela, Hellenius, Mai-Lis, van't Hooft, Ferdinand M., Olsson, Gunnar, Rust, Stephan, Assmann, Gerd, Barlera, Simona, Tognoni, Gianni, Franzosi, Maria Grazia, Linksted, Pamela, Green, Fiona R., Rasheed, Asif, Zaidi, Moazzam, Shah, Nabi, Samuel, Maria, Mallick, Nadeem H., Azhar, Muhammad, Zaman, Khan S., Samad, Abdus, Ishaq, Mohammad, Gardezi, Ali R., Memon, Fazal-ur-Rehman, Frossard, Philippe M., Spector, Tim, Peltonen, Leena, Nieminen, Markku S., Sinisalo, Juha, Salomaa, Veikko, Ripatti, Samuli, Bennett, Derrick, Leander, Karin, Gigante, Bruna, de Faire, Ulf, Pietri, Silvia, Gori, Francesca, Marchioli, Roberto, Sivapalaratnam, Suthesh, Kastelein, John J. P., Trip, Mieke D., Theodoraki, Eirini V., Dedoussis, George V., Engert, Jamie C., Yusuf, Salim, Anand, Sonia S., Peden, John F., Hopewell, Jemma C., Saleheen, Danish, Chambers, John C., Hager, Jorg, Soranzo, Nicole, Collins, Rory, Danesh, John, Elliott, Paul, Farrall, Martin, Stirrups, Kathy, Zhang, Weihua, Hamsten, Anders, Parish, Sarah, Lathrop, Mark, Watkins, Hugh, Clarke, Robert, Deloukas, Panos, Kooner, Jaspal S., Goel, Anuj, Ongen, Halit, Strawbridge, Rona J., Heath, Simon, Mälarstig, Anders, Helgadottir, Anna, Öhrvik, John, Murtaza, Muhammed, Potter, Simon, Hunt, Sarah E., Delepine, Marc, Jalilzadeh, Shapour, Axelsson, Tomas, Syvänen, Ann-Christine, Gwilliam, Rhian, Bumpstead, Suzannah, Gray, Emma, Edkins, Sarah, Folkersen, Lasse, Kyriakou, Theodosios, Franco-Cereceda, Anders, Gabrielsen, Anders, Seedorf, Udo, Eriksson, Per, Offer, Alison, Bowman, Louise, Sleight, Peter, Armitage, Jane, Peto, Richard, Abecasis, Goncalo, Ahmed, Nabeel, Caulfield, Mark, Donnelly, Peter, Froguel, Philippe, Kooner, Angad S., McCarthy, Mark I., Samani, Nilesh J., Scott, James, Sehmi, Joban, Silveira, Angela, Hellenius, Mai-Lis, van't Hooft, Ferdinand M., Olsson, Gunnar, Rust, Stephan, Assmann, Gerd, Barlera, Simona, Tognoni, Gianni, Franzosi, Maria Grazia, Linksted, Pamela, Green, Fiona R., Rasheed, Asif, Zaidi, Moazzam, Shah, Nabi, Samuel, Maria, Mallick, Nadeem H., Azhar, Muhammad, Zaman, Khan S., Samad, Abdus, Ishaq, Mohammad, Gardezi, Ali R., Memon, Fazal-ur-Rehman, Frossard, Philippe M., Spector, Tim, Peltonen, Leena, Nieminen, Markku S., Sinisalo, Juha, Salomaa, Veikko, Ripatti, Samuli, Bennett, Derrick, Leander, Karin, Gigante, Bruna, de Faire, Ulf, Pietri, Silvia, Gori, Francesca, Marchioli, Roberto, Sivapalaratnam, Suthesh, Kastelein, John J. P., Trip, Mieke D., Theodoraki, Eirini V., Dedoussis, George V., Engert, Jamie C., Yusuf, Salim, and Anand, Sonia S.
- Abstract
Genome-wide association studies have identified 11 common variants convincingly associated with coronary artery disease (CAD)(1-7), a modest number considering the apparent heritability of CAD(8). All of these variants have been discovered in European populations. We report a meta-analysis of four large genome-wide association studies of CAD, with similar to 575,000 genotyped SNPs in a discovery dataset comprising 15,420 individuals with CAD (cases) (8,424 Europeans and 6,996 South Asians) and 15,062 controls. There was little evidence for ancestry-specific associations, supporting the use of combined analyses. Replication in an independent sample of 21,408 cases and 19,185 controls identified five loci newly associated with CAD (P < 5 x 10(-8) in the combined discovery and replication analysis): LIPA on 10q23, PDGFD on 11q22, ADAMTS7-MORF4L1 on 15q25, a gene rich locus on 7q22 and KIAA1462 on 10p11. The CAD-associated SNP in the PDGFD locus showed tissue-specific cis expression quantitative trait locus effects. These findings implicate new pathways for CAD susceptibility.
- Published
- 2011
- Full Text
- View/download PDF
7. A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease.
- Author
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Nikpay M, Goel A, Won HH, Hall LM, Willenborg C, Kanoni S, Saleheen D, Kyriakou T, Nelson CP, Hopewell JC, Webb TR, Zeng L, Dehghan A, Alver M, Armasu SM, Auro K, Bjonnes A, Chasman DI, Chen S, Ford I, Franceschini N, Gieger C, Grace C, Gustafsson S, Huang J, Hwang SJ, Kim YK, Kleber ME, Lau KW, Lu X, Lu Y, Lyytikäinen LP, Mihailov E, Morrison AC, Pervjakova N, Qu L, Rose LM, Salfati E, Saxena R, Scholz M, Smith AV, Tikkanen E, Uitterlinden A, Yang X, Zhang W, Zhao W, de Andrade M, de Vries PS, van Zuydam NR, Anand SS, Bertram L, Beutner F, Dedoussis G, Frossard P, Gauguier D, Goodall AH, Gottesman O, Haber M, Han BG, Huang J, Jalilzadeh S, Kessler T, König IR, Lannfelt L, Lieb W, Lind L, Lindgren CM, Lokki ML, Magnusson PK, Mallick NH, Mehra N, Meitinger T, Memon FU, Morris AP, Nieminen MS, Pedersen NL, Peters A, Rallidis LS, Rasheed A, Samuel M, Shah SH, Sinisalo J, Stirrups KE, Trompet S, Wang L, Zaman KS, Ardissino D, Boerwinkle E, Borecki IB, Bottinger EP, Buring JE, Chambers JC, Collins R, Cupples LA, Danesh J, Demuth I, Elosua R, Epstein SE, Esko T, Feitosa MF, Franco OH, Franzosi MG, Granger CB, Gu D, Gudnason V, Hall AS, Hamsten A, Harris TB, Hazen SL, Hengstenberg C, Hofman A, Ingelsson E, Iribarren C, Jukema JW, Karhunen PJ, Kim BJ, Kooner JS, Kullo IJ, Lehtimäki T, Loos RJF, Melander O, Metspalu A, März W, Palmer CN, Perola M, Quertermous T, Rader DJ, Ridker PM, Ripatti S, Roberts R, Salomaa V, Sanghera DK, Schwartz SM, Seedorf U, Stewart AF, Stott DJ, Thiery J, Zalloua PA, O'Donnell CJ, Reilly MP, Assimes TL, Thompson JR, Erdmann J, Clarke R, Watkins H, Kathiresan S, McPherson R, Deloukas P, Schunkert H, Samani NJ, and Farrall M
- Subjects
- Humans, Phenotype, Coronary Artery Disease genetics, Genome, Human, Genome-Wide Association Study
- Abstract
Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is largely based on genome-wide association study (GWAS) analysis of common SNPs. Leveraging phased haplotypes from the 1000 Genomes Project, we report a GWAS meta-analysis of ∼185,000 CAD cases and controls, interrogating 6.7 million common (minor allele frequency (MAF) > 0.05) and 2.7 million low-frequency (0.005 < MAF < 0.05) variants. In addition to confirming most known CAD-associated loci, we identified ten new loci (eight additive and two recessive) that contain candidate causal genes newly implicating biological processes in vessel walls. We observed intralocus allelic heterogeneity but little evidence of low-frequency variants with larger effects and no evidence of synthetic association. Our analysis provides a comprehensive survey of the fine genetic architecture of CAD, showing that genetic susceptibility to this common disease is largely determined by common SNPs of small effect size.
- Published
- 2015
- Full Text
- View/download PDF
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