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1. Impact of SARS-CoV-2 Infection on the Association Between Laboratory Tests and Severe Outcomes Among Hospitalized Children.

Author

Xie, Jianling, Kuppermann, Nathan, Florin, Todd, Tancredi, Daniel, Funk, Anna, Kim, Kelly, Salvadori, Marina, Yock-Corrales, Adriana, Shah, Nipam, Breslin, Kristen, Chaudhari, Pradip, Bergmann, Kelly, Ahmad, Fahd, Nebhrajani, Jasmine, Mintegi, Santiago, Gangoiti, Iker, Plint, Amy, Avva, Usha, Gardiner, Michael, Malley, Richard, Finkelstein, Yaron, Dalziel, Stuart, Bhatt, Maala, Kannikeswaran, Nirupama, Caperell, Kerry, Campos, Carmen, Sabhaney, Vikram, Chong, Shu-Ling, Lunoe, Maren, Rogers, Alexander, Becker, Sarah, Borland, Meredith, Sartori, Laura, Pavlicich, Viviana, Rino, Pedro, Morrison, Andrea, Neuman, Mark, Poonai, Naveen, Simon, Norma-Jean, Kam, April, Kwok, Maria, Morris, Claudia, Palumbo, Laura, Ambroggio, Lilliam, Navanandan, Nidhya, Eckerle, Michelle, Klassen, Terry, Payne, Daniel, Cherry, Jonathan, Waseem, Muhammad, Dixon, Andrew, Ferre, Isabel, and Freedman, Stephen

Subjects
C-reactive protein, COVID-19, SARS-CoV-2, child, lymphopenia, procalcitonin
Abstract

BACKGROUND: To assist clinicians with identifying children at risk of severe outcomes, we assessed the association between laboratory findings and severe outcomes among severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected children and determined if SARS-CoV-2 test result status modified the associations. METHODS: We conducted a cross-sectional analysis of participants tested for SARS-CoV-2 infection in 41 pediatric emergency departments in 10 countries. Participants were hospitalized, had laboratory testing performed, and completed 14-day follow-up. The primary objective was to assess the associations between laboratory findings and severe outcomes. The secondary objective was to determine if the SARS-CoV-2 test result modified the associations. RESULTS: We included 1817 participants; 522 (28.7%) SARS-CoV-2 test-positive and 1295 (71.3%) test-negative. Seventy-five (14.4%) test-positive and 174 (13.4%) test-negative children experienced severe outcomes. In regression analysis, we found that among SARS-CoV-2-positive children, procalcitonin ≥0.5 ng/mL (adjusted odds ratio [aOR], 9.14; 95% CI, 2.90-28.80), ferritin >500 ng/mL (aOR, 7.95; 95% CI, 1.89-33.44), D-dimer ≥1500 ng/mL (aOR, 4.57; 95% CI, 1.12-18.68), serum glucose ≥120 mg/dL (aOR, 2.01; 95% CI, 1.06-3.81), lymphocyte count

Published
2023

3. Corticosteroids and Other Treatments Administered to Children Tested for SARS-CoV-2 Infection in Emergency Departments.

Author

Freedman, Stephen B, Kuppermann, Nathan, Funk, Anna L, Kim, Kelly, Xie, Jianling, Tancredi, Daniel, Dalziel, Stuart R, Neuman, Mark I, Mintegi, Santiago, Plint, Amy C, Gómez-Vargas, Jessica, Finkelstein, Yaron, Ambroggio, Lilliam, Klassen, Terry P, Salvadori, Marina, Malley, Richard, Payne, Daniel C, Florin, Todd A, and Pediatric Emergency Research Network-COVID-19 Study Team

Subjects
Pediatric Emergency Research Network-COVID-19 Study Team, Humans, Adrenal Cortex Hormones, Nucleic Acids, Cross-Sectional Studies, Adolescent, Child, Emergency Service, Hospital, SARS-CoV-2, COVID-19 Drug Treatment, COVID-19, adrenal cortex hormones, child, hospitalized, emergency service, hospital, Emerging Infectious Diseases, Pediatric, Vaccine Related, Prevention, Clinical Trials and Supportive Activities, Biodefense, Clinical Research, Lung, Infectious Diseases, Respiratory, child, hospitalized, emergency service, hospital, Paediatrics and Reproductive Medicine, Pediatrics
Abstract

ObjectiveWe sought to determine if corticosteroid administration is associated with a SARS-CoV-2 nucleic acid test-positive result and to describe therapies administered to SARS-CoV-2 infected children.MethodsWe collected cross-sectional data from participants recruited in 41 pediatric emergency departments (ED) in 10 countries between March 2020 and June 2021. Participants were

Published
2022

7. Prospective cohort study of children with suspected SARS-CoV-2 infection presenting to paediatric emergency departments: a Paediatric Emergency Research Networks (PERN) Study Protocol.

Author

Funk, Anna L, Florin, Todd A, Dalziel, Stuart R, Mintegi, Santiago, Salvadori, Marina I, Tancredi, Daniel Joseph, Neuman, Mark I, Payne, Daniel C, Plint, Amy C, Klassen, Terry P, Malley, Richard, Ambroggio, Lilliam, Kim, Kelly, Kuppermann, Nathan, and Freedman, Stephen B

Subjects
Humans, Hospitalization, Risk Factors, Prospective Studies, Research Design, International Cooperation, Child, Emergency Service, Hospital, Pediatric Emergency Medicine, COVID-19, SARS-CoV-2, epidemiology, paediatric a&e and ambulatory care, paediatric infectious disease & immunisation, paediatric intensive & critical care, Clinical Sciences, Public Health and Health Services, Other Medical and Health Sciences
Abstract

IntroductionRelatively limited data are available regarding paediatric COVID-19. Although most children appear to have mild or asymptomatic infections, infants and those with comorbidities are at increased risk of experiencing more severe illness and requiring hospitalisation due to COVID-19. The recent but uncommon association of SARS-CoV-2 infection with development of a multisystem inflammatory syndrome has heightened the importance of understanding paediatric SARS-CoV-2 infection.Methods and analysisThe Paediatric Emergency Research Network-COVID-19 cohort study is a rapid, global, prospective cohort study enrolling 12 500 children who are tested for acute SARS-CoV-2 infection. 47 emergency departments across 12 countries on four continents will participate. At enrolment, regardless of SARS-CoV-2 test results, all children will have the same information collected, including clinical, epidemiological, laboratory, imaging and outcome data. Interventions and outcome data will be collected for hospitalised children. For all children, follow-up at 14 and 90 days will collect information on further medical care received, and long-term sequelae, respectively. Statistical models will be designed to identify risk factors for infection and severe outcomes.Ethics and disseminationSites will seek ethical approval locally, and informed consent will be obtained. There is no direct risk or benefit of study participation. Weekly interim analysis will allow for real-time data sharing with regional, national, and international policy makers. Harmonisation and sharing of investigation materials with WHO, will contribute to synergising global efforts for the clinical characterisation of paediatric COVID-19. Our findings will enable the implementation of countermeasures to reduce viral transmission and severe COVID-19 outcomes in children.Trial registration numberNCT04330261.

Published
2021

8. Contributors

Author

Abzug, Mark J., primary, Acharya, Priyamvada, additional, Acosta, Anna M., additional, Ahmed, S. Sohail, additional, Amanna, Ian J., additional, Anderson, Annaliesa S., additional, Asturias, Edwin J., additional, Bachmann, Martin F., additional, Bahl, Sunil, additional, Bailey, Justin R., additional, Baker, Carol J., additional, Balfour, Henry H., additional, Baric, Ralph S., additional, Barnett, Elizabeth D., additional, Barrett, Alan D.T., additional, Belser, Jessica A., additional, Berzofsky, Jay A., additional, Bethony, Jeffrey M., additional, Brewer-Jensen, Paul D., additional, Bubak, Andrew N., additional, Burns, Cara C., additional, Caplan, Arthur L., additional, Cavaleri, Marco, additional, Chandran, Aruna, additional, Cherian, Thomas, additional, Clemens, John D., additional, Cochino, Emil, additional, Cohet, Catherine, additional, Cohn, Amanda, additional, Cortese, Margaret M., additional, Crowcroft, Natasha S., additional, Curtis, Nigel, additional, Damron, F. Heath, additional, Danchin, Margie, additional, Debbink, Kari, additional, Desai, Sachin N., additional, Davis, Emily H., additional, Decker, Michael D., additional, Denison, Mark R., additional, DeStefano, Frank, additional, Douglas, R. Gordon, additional, Dreher-Lesnick, Sheila M., additional, Eberhardt, Christiane S., additional, Edmunds, W. John, additional, Edwards, Caitlin E., additional, Edwards, Kathryn M., additional, Eggers, Rudolf, additional, Ellis, Ronald, additional, Erdman, Dean D., additional, Ertl, Hildegund C.J., additional, Estivariz, Concepcion F., additional, Fine, Paul E.M., additional, Finn, Theresa M., additional, Fisher, Allison M., additional, Fitzwater, Sean Patrick, additional, Freedman, Mark S., additional, Friede, Martin, additional, Friedlander, Arthur M., additional, Frumento, Nicole, additional, Fry, Alicia M., additional, Garçon, Nathalie, additional, Geris, Jennifer M., additional, Gershon, Anne A., additional, Gervier, Regis, additional, Gessner, Bradford D., additional, Gilbert, Peter B., additional, Gomez, Phillip Louis, additional, Ginsberg, Ann M., additional, Grabenstein, John D., additional, Graham, Rachel L., additional, Graham, Barney S., additional, Granoff, Dan M., additional, Gray, Gregory C., additional, Greenberg, David P., additional, Grohskopf, Lisa A., additional, Gruber, Marion F., additional, Guerena, Fernando B., additional, Havelange, Nicolas, additional, Halstead, Scott B., additional, Hanekom, Willem A., additional, Harrison, Lee H., additional, Hawn, Thomas R., additional, Haynes, Barton F., additional, Healy, C. Mary, additional, Hills, Susan L., additional, Hirabayashi, Kuniko, additional, Holmgren, Jan, additional, Hombach, Joachim M., additional, Hotez, Peter Jay, additional, Howe, Barbara J., additional, Hunegnaw, Ruth, additional, Izopet, Jacques, additional, Jamieson, Denise J., additional, Jansen, Kathrin, additional, Jarrahian, Courtney, additional, Johansen, Kari, additional, Kahn, Geoffrey D., additional, Karron, Ruth A., additional, Katz, Jacqueline M., additional, Kennedy, Richard B., additional, Broojerdi, Alireza Khadem, additional, Khetsuriani, Nino, additional, Khudyakov, Yury, additional, Klugman, Keith P., additional, Kocher, Jacob F., additional, Kollaritsch, Herwig, additional, Kotloff, Karen L., additional, Kozarsky, Phyllis E., additional, Kreimer, Aimée R., additional, Kroger, Andrew T., additional, Kwong, Peter D., additional, Lal, Manjari, additional, Levin, Myron J., additional, Levine, Myron M., additional, Lindesmith, Lisa C., additional, Lindstrand, Ann, additional, Ljungman, Per, additional, Lowy, Douglas R., additional, Lundgren, Anna, additional, Lydon, Patrick, additional, Macklin, Grace R., additional, Maeng, Hoyoung M., additional, Mahalingam, Ravi, additional, Malley, Richard, additional, Mallory, Michael L., additional, Marfin, Anthony A., additional, Markowitz, Lauri E., additional, Marshall, CDR Valerie, additional, McCollum, Andrea, additional, Meyer, Sarah, additional, McNamara, Lucy A., additional, Menning, Lisa, additional, Messacar, Kevin, additional, Miller, Mark A., additional, Milutinovic, Pavle, additional, Modlin, John F., additional, Monath, Thomas P., additional, Morabito, Kaitlyn M., additional, Moss, William J., additional, Mulholland, Kim, additional, Mura, Manuela, additional, Musher, Daniel M., additional, Nagel, Maria A., additional, Nair, G. Balakrish, additional, Nelson, Noele P., additional, Netea, Mihai G., additional, Neuzil, Kathleen Maletic, additional, Niemeyer, Christy S., additional, Nohynek, Hanna, additional, Norheim, Gunnstein, additional, Nussbaum, Lauren, additional, O’Brien, Katherine L., additional, O’Leary, Sean, additional, Ockenhouse, Christian, additional, Offit, Paul A., additional, Okwo-Bele, Jean-Marie, additional, Olkhanud, Purevdorj B., additional, Omer, Saad B., additional, Orenstein, Walter A., additional, Oyston, Petra C.F., additional, Parashar, Umesh D., additional, Patel, Manish M., additional, Payne, Daniel C., additional, Pebody, Richard, additional, Pecetta, Simone, additional, Perlman, Stanley, additional, Pierson, Benjamin, additional, Pierson, Theodore C., additional, Pittet, Laure F., additional, Pittman, Phillip R., additional, Plotkin, Stanley A., additional, Plotkin, Susan L., additional, Poland, Gregory A., additional, Pollard, Sir Andrew John, additional, Poovorawan, Yong, additional, Proctor, Richard A., additional, Qadri, Firdausi, additional, Rao, Agam, additional, Rappuoli, Rino, additional, Reef, Susan E., additional, Rogalewicz, Joseph A., additional, Robinson, James Michael, additional, Roesel, Sigrun, additional, Rubin, Steven A., additional, Rupprecht, Charles E., additional, Rutter, Paul, additional, Samant, Vijay B., additional, Sambhara, Suryaprakash, additional, Samies, Nicole L., additional, Santosham, Mathuram, additional, Saunders, Kevin O., additional, Schiller, John T., additional, Schleiss, Mark R., additional, Schuerman, Lode, additional, Schwab, Jennifer, additional, Schwartz, Jason L., additional, Scobie, Heather M., additional, Scott, J. Anthony, additional, Shapiro, Eugene D., additional, Shenoy, Erica S., additional, Shimabukuro, Tom T., additional, Shouval, Daniel, additional, Siegrist, Claire-Anne, additional, Sitrin, Robert D., additional, Skinner, Nicole E., additional, Slifka, Mark K., additional, Sodha, Samir V., additional, Soeters, Heidi M., additional, Solomon, Tom, additional, Speiser, Daniel E., additional, Staples, J. Erin, additional, Steffen, Robert, additional, Stephens, David S., additional, Strebel, Peter M., additional, Subbarao, Kanta, additional, Sullivan, Nancy J., additional, Takashima, Yoshihiro, additional, Tate, Jacqueline E., additional, Tayman, Alice, additional, Telford, Sam R., additional, Thombley, Melisa, additional, Thomsen, Isaac, additional, Tohme, Rania A., additional, Trabold, Malin, additional, El-Turabi, Aadil, additional, Vaughn, David W., additional, Verardi, Raffaello, additional, Vicari, Andrea S., additional, Vidor, Emmanuel J., additional, Villafana, Tonya, additional, Vogt, Matthew R., additional, Walker, Mark J., additional, Walsh, Nick M., additional, Wanlapakorn, Nasamon, additional, Ward, John W., additional, Wassilak, Steven G.F., additional, Watts, Lisa A., additional, Weber, David J., additional, Weiner, David B., additional, Weng, Mark K., additional, Wexler, Deborah L., additional, Wharton, Melinda, additional, Whitley, Richard J., additional, Whitney, Cynthia G., additional, Wiehe, Kevin, additional, Williamson, E. Diane, additional, Wormser, Gary P., additional, Xia, Ningshao, additional, Yildirim, Inci, additional, Zehrung, Darin, additional, and Zweigart, Mark R., additional

Published
2023
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10. Household Transmission Dynamics of Asymptomatic SARS-CoV-2–Infected Children: A Multinational, Controlled Case-Ascertained Prospective Study

Author

Funk, Anna, primary, Florin, Todd A, additional, Kuppermann, Nathan, additional, Finkelstein, Yaron, additional, Kazakoff, Alissa, additional, Baldovsky, Michael, additional, Tancredi, Daniel J, additional, Breslin, Kristen, additional, Bergmann, Kelly R, additional, Gardiner, Michael, additional, Pruitt, Christopher M, additional, Liu, Deborah R, additional, Neuman, Mark I, additional, Wilkinson, Matthew, additional, Ambroggio, Lilliam, additional, Pang, Xiao-Li, additional, Cauchemez, Simon, additional, Malley, Richard, additional, Klassen, Terry P, additional, Lee, Bonita E, additional, Payne, Daniel C, additional, Mahmud, Salaheddin M, additional, and Freedman, Stephen B, additional

Published
2024
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11. Features Associated With Radiographic Pneumonia in Children with SARS-CoV-2

Author

Florin, Todd A, primary, Freedman, Stephen B, additional, Xie, Jianling, additional, Funk, Anna L, additional, Tancredi, Daniel J, additional, Kim, Kelly, additional, Neuman, Mark I, additional, Yock-Corrales, Adriana, additional, Bergmann, Kelly R, additional, Breslin, Kristen A, additional, Finkelstein, Yaron, additional, Ahmad, Fahd A, additional, Avva, Usha R, additional, Lunoe, Maren M, additional, Chaudhari, Pradip P, additional, Shah, Nipam P, additional, Plint, Amy C, additional, Sabhaney, Vikram J, additional, Sethuraman, Usha, additional, Gardiner, Michael A, additional, Sartori, Laura F, additional, Wright, Bruce, additional, Navanandan, Nidhya, additional, Mintegi, Santiago, additional, Gangoiti, Iker, additional, Borland, Meredith L, additional, Chong, Shu-Ling, additional, Kwok, Maria Y, additional, Eckerle, Michelle, additional, Poonai, Naveen, additional, Romero, Carlos Miguel Angelats, additional, Waseem, Muhammad, additional, Nebhrajani, Jasmine R, additional, Bhatt, Maala, additional, Caperell, Kerry, additional, Campos, Carmen, additional, Becker, Sarah M, additional, Morris, Claudia R, additional, Rogers, Alexander J, additional, Kam, April J, additional, Pavlicich, Viviana, additional, Palumbo, Laura, additional, Dalziel, Stuart R, additional, Morrison, Andrea K, additional, Rino, Pedro B, additional, Cherry, Jonathan C, additional, Salvadori, Marina I, additional, Ambroggio, Lilliam, additional, Klassen, Terry P, additional, Payne, Daniel C, additional, Malley, Richard, additional, Simon, Norma-Jean, additional, and Kuppermann, Nathan, additional

Published
2024
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13. Vaccination for healthy aging.

Author

Bloom, David E., Pecetta, Simone, Scorza, Francesco Berlanda, Carfi, Andrea, Carleton, Bruce, Cipriano, Mariateresa, Edwards, Kathryn, Gasperini, Gianmarco, Malley, Richard, Nandi, Arindam, Nguyen, Aurelia, Stuart, Lynda, Black, Steve, and Rappuoli, Rino

Subjects
AGING, VACCINE hesitancy, ADULT development, VACCINATION, IMMUNOSENESCENCE
Abstract

As the world's population grows older, vaccination is becoming a key strategy for promoting healthy aging. Despite scientific progress in adult vaccine development, obstacles such as immunosenescence and vaccine hesitancy remain. To unlock the potential of adult vaccines fully, we must enhance immunization programs, dispel misinformation, and invest in research that deepens our understanding of aging and immunity. [ABSTRACT FROM AUTHOR]

Published
2024
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19. The Classical Lancefield Antigen of Group A Streptococcus Is a Virulence Determinant with Implications for Vaccine Design

Author

van Sorge, Nina M, Cole, Jason N, Kuipers, Kirsten, Henningham, Anna, Aziz, Ramy K, Kasirer-Friede, Ana, Lin, Leo, Berends, Evelien TM, Davies, Mark R, Dougan, Gordon, Zhang, Fan, Dahesh, Samira, Shaw, Laura, Gin, Jennifer, Cunningham, Madeleine, Merriman, Joseph A, Hütter, Julia, Lepenies, Bernd, Rooijakkers, Suzan HM, Malley, Richard, Walker, Mark J, Shattil, Sanford J, Schlievert, Patrick M, Choudhury, Biswa, and Nizet, Victor

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Research, Emerging Infectious Diseases, Vaccine Related, Infectious Diseases, Immunization, Prevention, 2.2 Factors relating to the physical environment, Aetiology, Infection, Good Health and Well Being, Acetylglucosamine, Animals, Antibodies, Bacterial, Antigens, Bacterial, Antimicrobial Cationic Peptides, Bacterial Proteins, Carbohydrates, Cathelicidins, Epitopes, Female, Glycosyltransferases, Host-Pathogen Interactions, Humans, Immunity, Innate, Male, Mice, Inbred Strains, Mutagenesis, Neutrophils, Rabbits, Streptococcal Infections, Streptococcal Vaccines, Streptococcus pyogenes, Virulence Factors, Microbiology, Immunology, Biochemistry and cell biology, Medical microbiology
Abstract

Group A Streptococcus (GAS) is a leading cause of infection-related mortality in humans. All GAS serotypes express the Lancefield group A carbohydrate (GAC), comprising a polyrhamnose backbone with an immunodominant N-acetylglucosamine (GlcNAc) side chain, which is the basis of rapid diagnostic tests. No biological function has been attributed to this conserved antigen. Here we identify and characterize the GAC biosynthesis genes, gacA through gacL. An isogenic mutant of the glycosyltransferase gacI, which is defective for GlcNAc side-chain addition, is attenuated for virulence in two infection models, in association with increased sensitivity to neutrophil killing, platelet-derived antimicrobials in serum, and the cathelicidin antimicrobial peptide LL-37. Antibodies to GAC lacking the GlcNAc side chain and containing only polyrhamnose promoted opsonophagocytic killing of multiple GAS serotypes and protected against systemic GAS challenge after passive immunization. Thus, the Lancefield antigen plays a functional role in GAS pathogenesis, and a deeper understanding of this unique polysaccharide has implications for vaccine development.

Published
2014

20. Induction of Broad Immunity against Invasive Salmonella Disease by a Quadrivalent Combination Salmonella MAPS Vaccine Targeting Salmonella Enterica Serovars Typhimurium, Enteritidis, Typhi, and Paratyphi A

Author

Boerth, Emily M., primary, Gong, Joyce, additional, Roffler, Becky, additional, Thompson, Claudette M., additional, Song, Boni, additional, Malley, Sasha F., additional, Hirsch, Angelika, additional, MacLennan, Calman A., additional, Zhang, Fan, additional, Malley, Richard, additional, and Lu, Ying-Jie, additional

Published
2023
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22. Re-emergence of the type 1 pilus among Streptococcus pneumoniae isolates in Massachusetts, USA

Author

Regev-Yochay, Gili, Hanage, William P, Trzcinski, Krzysztof, Rifas-Shiman, Sheryl L, Lee, Grace, Bessolo, Andrew, Huang, Susan S, Pelton, Stephen I, McAdam, Alexander J, Finkelstein, Jonathan A, Lipsitch, Marc, and Malley, Richard

Subjects
Pneumonia, Clinical Research, Immunization, Infectious Diseases, Pneumonia & Influenza, Lung, Vaccine Related, Prevention, Infection, Carrier State, Child, Child, Preschool, DNA, Bacterial, Drug Resistance, Bacterial, Female, Fimbriae Proteins, Humans, Male, Massachusetts, Nasopharynx, Operon, Pneumococcal Infections, Pneumococcal Vaccines, Streptococcus pneumoniae, S. pneumoniae pilus, PCV7, Vaccine- and non-vaccine-types, article, bacterium isolate, bacterium pilus, child, human, human tissue, nasopharyngeal aspiration, nonhuman, pneumococcal infection, Pneumococcal type 1 pilus, prevalence, priority journal, school child, United States, Biological Sciences, Agricultural and Veterinary Sciences, Medical and Health Sciences, Virology
Abstract

Pneumococcal type 1 pilus proteins have been proposed as potential vaccine candidates. Following conjugate pneumococcal vaccination, the prevalence of the pneumococcal type 1 pilus declined dramatically, a decline associated with the elimination of vaccine-type (VT) strains. Here we show that between 2004 and 2007, there has been a significant increase in pilus prevalence, now exceeding rates from the pre-conjugate vaccine era. This increase is primarily due to non-VT strains. These emerging piliated non-VT strains are mostly novel clones, with some exceptions. The rise in pilus type 1 frequency across multiple distinct genetic backgrounds suggests that the pilus may confer an intrinsic advantage.

Published
2010

29. Therapeutic immunization with a whole cell vaccine reduces pneumococcal nasopharyngeal density, shedding, and middle ear infection in mice

Author

Manning, Jayne, primary, Manna, Sam, additional, Dunne, Eileen M, additional, Bongcaron, Viktoria, additional, Pell, Casey, additional, Patterson, Natalie L, additional, Kuil, Sacha D, additional, Dhar, Poshmaal, additional, Goldblatt, David, additional, Mulholland, E Kim, additional, Licciardi, Paul V, additional, Robins-Browne, Roy M, additional, Malley, Richard, additional, Wijburg, Odilia, additional, and Satzke, Catherine, additional

Published
2023
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31. Contributors

Author

Abrignani, Sergio, primary, Ahmed, S. Sohail, additional, Amanna, Ian J., additional, Anderson, Teresa A., additional, Arlett, Peter R., additional, Atkinson, William L., additional, Averhoff, Francisco M., additional, Aylward, R. Bruce, additional, Bachmann, Martin F., additional, Baker, Carol J., additional, Balfour, Henry H., additional, Ballou, W. Ripley, additional, Baric, Ralph S., additional, Barrett, Alan D.T., additional, Barnett, Elizabeth D., additional, Belgharbi, Lahouari, additional, Berinstein, Elliot M., additional, Berinstein, Neil L., additional, Bethony, Jeffrey M., additional, Bogaerts, Hugues, additional, Bot, Adrian, additional, Brachman, Philip S., additional, Bresee, Joseph S., additional, Broojerdi, Alireza Khadem, additional, Caplan, Arthur L., additional, Cavaleri, Marco, additional, Cherian, Thomas, additional, Choi-Sing, Pele, additional, Clemens, John D., additional, Cochi, Stephen L., additional, Cohn, Amanda, additional, Cortese, Capt. Margaret M., additional, Cox, Nancy J., additional, Cutts, Felicity, additional, Dagan, Ron, additional, Dalton, Harry R., additional, Daum, Robert S., additional, Davey, Andrea Sudell, additional, De Francesco, Raffaele, additional, Debbink, Kari, additional, Decker, Michael D., additional, Desai, Sachin N., additional, DeStefano, Frank, additional, Douglas, R. Gordon, additional, Dubischar, Katrin, additional, Edmunds, W. John, additional, Edwards, Kathryn M., additional, Egan, William, additional, Eggers, Rudolf, additional, Ehmann, Falk, additional, Ellis, Ronald W., additional, El-Turabi, Aadil, additional, Erdman, Dean D., additional, Ertl, Hildegund, additional, Fine, Paul E.M., additional, Finn, Theresa M., additional, Fisher, Allison, additional, Friede, Martin, additional, Friedlander, Arthur M., additional, Fry, Alicia M., additional, Garçon, Nathalie, additional, Gastañaduy, Paul A., additional, Gershman, Mark D., additional, Gershon, Anne A., additional, Gessner, Bradford D., additional, Gilbert, Peter, additional, Ginsberg, Ann M., additional, Girard, Marc P., additional, Gomez, Phillip L., additional, Goodson, James L., additional, Goodwin, Robert R., additional, Gordon, Lance K., additional, Grabenstein, John D., additional, Graham, Barney S., additional, Graham, Rachel L., additional, Granoff, Dan M., additional, Gray, Gregory C., additional, Gruber, Marion F., additional, Halstead, Scott B., additional, Hanekom, Willem, additional, Harrison, Lee H., additional, Hawn, Thomas R., additional, Healy, C. Mary, additional, Henderson, Donald A., additional, Hildesheim, Allan, additional, Hills, Susan L., additional, Holmgren, Jan, additional, Hombach, Joachim, additional, Hotez, Peter J., additional, Houghton, Michael, additional, Houston, Avril Melissa, additional, Howe, Barbara J., additional, Izopet, Jacques, additional, Jamieson, Denise J., additional, Jarrahian, Courtney, additional, Johansen, Kari, additional, Karron, Ruth A., additional, Kennedy, Richard B., additional, Kew, Olen M., additional, Khudyakov, Yury, additional, Klein, Michel, additional, Klugman, Keith P., additional, Kocher, Jacob F., additional, Koff, Wayne C., additional, Kollaritsch, Herwig, additional, Kotloff, Karen L., additional, Kozarsky, Phyllis E., additional, Kroger, Andrew T., additional, Kurz, Xavier, additional, Lakdawala, Seema S., additional, Lane, J. Michael, additional, Leigh, Kendra, additional, Levin, Myron J., additional, Levine, Emily Marcus, additional, Levine, Myron M., additional, Lindesmith, Lisa C., additional, Ljungman, Per, additional, Lowy, Douglas R., additional, Luke, Catherine J., additional, Lundgren, Anna, additional, Lydon, Patrick, additional, Malley, Richard, additional, Marin, Mona, additional, Markowitz, Lauri E., additional, Marshall, Lieut. Valerie B., additional, Miller, Mark A., additional, Monath, Thomas P., additional, Moss, William J., additional, Mulholland, Kim, additional, Musher, Daniel M., additional, Nabel, Gary J., additional, Nagarajan, Thirumeni, additional, Nair, GB, additional, Nanduri, Srinivas Acharya, additional, Neddermann, Petra, additional, Nelson, Noele P., additional, Offit, Paul A., additional, Okwo-Bele, Jean-Marie, additional, Omer, Saad B., additional, Orenstein, Walter A., additional, Oyston, Petra C.F., additional, Papania, Mark J., additional, Parashar, Umesh D., additional, Pfeifer, Dina, additional, Pickering, Larry K., additional, Pittman, Phillip R., additional, Ploquin, Aurélie, additional, Plotkin, Stanley A., additional, Plotkin, Susan L., additional, Poland, Gregory A., additional, Pollard, Andrew J., additional, Qadri, Firdausi, additional, Quirk, Mary R., additional, Rao, Raman D.S.V., additional, Rappuoli, Rino, additional, Reef, Susan E., additional, Ridpath, Alison D., additional, Robinson, James M., additional, Rodewald, Lance E., additional, Rodriguez-Hernandez, Carmen A., additional, Roper, Martha H., additional, Rubin, Steven A., additional, Rupprecht, Charles E., additional, Rutala, William A., additional, Salisbury, David, additional, Samant, Vijay B., additional, Sambhara, Suryaprakash, additional, Santosham, Mathuram, additional, Schiller, John T., additional, Schleiss, Mark R., additional, Schuchat, Anne, additional, Schwartz, Jason L., additional, Scobie, Heather M., additional, Scott, J. Anthony, additional, Seward, Jane F., additional, Shouval, Daniel, additional, Siegrist, Claire-Anne, additional, Slifka, Mark K., additional, Sodha, Samir V., additional, Stanberry, Lawrence R., additional, Staples, J. Erin, additional, Steere, Allen C., additional, Steffen, Robert, additional, Strebel, Peter M., additional, Subbarao, Kanta, additional, Sullivan, Nancy J., additional, Sutcliffe, Catherine G., additional, Sutherland, Andrea R., additional, Sutter, Roland W., additional, Thomas, Stephen J., additional, Tiwari, Tejpratap S.P, additional, Tsai, Theodore F., additional, Van Damme, Pierre, additional, Vekemans, Johan, additional, Vidor, Emmanuel, additional, Ward, John W., additional, Wassilak, Steven G.F., additional, Weber, David J., additional, Weiner, David B., additional, Wexler, Deborah L., additional, Wharton, Melinda, additional, Whitney, Cynthia G., additional, Williamson, E. Diane, additional, Wood, David J., additional, Xia, Ningshao, additional, Xu, Zhi Yi, additional, Zanetti, Alessandro, additional, and Zehrung, Darin, additional

Published
2018
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38. Contributors

Author

Abu-Raya, Bahaa, Ambalavanan, Namasivayam, Archary, Moherndran, Arditi, Moshe, Barnett, Elizabeth D., Bendel, Catherine M., Benjamin, Daniel K., Jr., Bode, Lars, Bradley, John S., Brasil, Patricia, Cassat, James E., Cherry, James D., Coffin, Susan E., D’Angio, Carl T., Darmstadt, Gary L., Darville, Toni, Edwards, Kathryn M., Embree, Joanne E., Freitag, Nancy Elizabeth, Fuller, Trevon L., Gantt, Soren, Garweg, Justus G., Gigliotti, Francis, Gordon, Scott M., Hanekom, Willem A., Hawn, Thomas R., Heininger, Ulrich, Hunstad, David A., Imam, Farhad B., James, Scott H., John, Audrey Ragan Odom, Karnsakul, Wikrom, Kieffer, François, Kim, Jae H., Kimberlin, David W., Klein, Jerome O., Koch, William C., Krogstad, Paul, Krysan, Damian Joseph, Lawrence, Shelley M., Levy, Ofer, Lewis, David B., Liu, George Y., Lucero, Yalda C., Maldonado, Yvonne A., Malley, Richard, Mandelbrot, Laurent, Marshall, Beth C., Mathew, Roshni, McKinney, Jeffrey, Moreira, Alvaro G., Moss, William J., Moujaes, Lea, Nielsen-Saines, Karin, Nieves, Delma J., Nizet, Victor, Ogra, Pearay L., O’Ryan, Miguel L., Permar, Sallie R., Peyron, François, Plotkin, Stanley A., Puopolo, Karen Marie, Ratner, Adam J., Reef, Susan E., Remington, Jack S., Riley, Laura E., Same, Rebecca G., Sammons, Julia Shaklee, Schwarz, Kathleen B., Schwenk, Hayden T., Shapiro, Eugene D., Shetty, Avinash K., Sood, Sunil K., Swamy, Geeta Krishna, Swanson, Elizabeth C., Ulloa, Erlinda R., Velarde, Jorge J., Viscardi, Rose Marie, Wade, Kelly C., Waites, Ken B., Wallon, Martine, Weinberg, Geoffrey A., Weiner, Lukasz D., Weitkamp, Joern-Hendrik, Wright, Terry W., Wynn, James L., and Zaidi, Anita K.M.

Published
2025
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39. Targeted Transcriptomic Screen of Pneumococcal Genes Expressed during Murine and Human Infection

Author

Basset, Alan, primary, Wall, Emma, additional, Mitsi, Elena, additional, Deshusses, Chloe, additional, Daly, Raecliffe, additional, Pojar, Sherin, additional, Reiné, Jesús, additional, Guerra-Assuncao, Jose Afonso, additional, Denis, Brigitte, additional, Jochems, Simon P., additional, Heyderman, Robert, additional, Brown, Jeremy, additional, Lu, Ying-Jie, additional, Ferreira, Daniela M., additional, and Malley, Richard, additional

Published
2022
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40. Antibody Seronegativity in COVID-19 RT-PCR–Positive Children

Author

Bhatt, Maala, primary, Zemek, Roger L., additional, Tang, Ken, additional, Malley, Richard, additional, Plint, Amy C., additional, Pham-Huy, Anne, additional, Dawson, Jennifer, additional, McGahern, Candice, additional, Pelchat, Martin, additional, Arnold, Corey, additional, Galipeau, Yannick, additional, and Langlois, Marc-André, additional

Published
2022
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47. Post–COVID-19 Conditions Among Children 90 Days After SARS-CoV-2 Infection

Author

Pediatría, Pediatria, Funk, Anna L., Kuppermann, Nathan, Florin, Todd A., Tancredi, Daniel J., Xie, Jianling, Kim, Kelly, Finkelstein, Yaron, Neuman, Mark I., Salvadori, Marina I., Yock-Corrales, Adriana, Breslin, Kristen A., Ambroggio, Lilliam, Chaudhari, Pradip P., Bergmann, Kelly R., Gardiner, Michael A., Nebhrajani, Jasmine R., Campos, Carmen, Ahmad, Fahd A., Sartori, Laura F., Navanandan, Nidhya, Kannikeswaran, Nirupama, Caperell, Kerry, Morris, Claudia R., Mintegi Raso, Santiago, Gangoiti, Iker, Sabhaney, Vikram J., Plint, Amy C., Klassen, Terry P., Avva, Usha R., Shah, Nipam P., Dixon, Andrew C., Lunoe, Maren M., Becker, Sarah M., Rogers, Alexander J., Pavlicich, Viviana, Dalziel, Stuart R., Payne, Daniel C., Malley, Richard, Borland, Meredith L., Morrison, Andrea K., Bhatt, Maala, Rino, Pedro B., Beneyto Ferre, Isabel, Eckerle, Michelle, Kam, April J., Chong, Shu-Ling, Palumbo, Laura, Kwok, Maria Y., Cherry, Jonathan C., Poonai, Naveen, Waseem, MD; Norma-Jean Simon, MPH, Waseem, Muhammad, Simon, Norma-Jean, Freedman, Stephen B., Pediatric Emergency Research Network–COVID-19 Study Team, Pediatría, Pediatria, Funk, Anna L., Kuppermann, Nathan, Florin, Todd A., Tancredi, Daniel J., Xie, Jianling, Kim, Kelly, Finkelstein, Yaron, Neuman, Mark I., Salvadori, Marina I., Yock-Corrales, Adriana, Breslin, Kristen A., Ambroggio, Lilliam, Chaudhari, Pradip P., Bergmann, Kelly R., Gardiner, Michael A., Nebhrajani, Jasmine R., Campos, Carmen, Ahmad, Fahd A., Sartori, Laura F., Navanandan, Nidhya, Kannikeswaran, Nirupama, Caperell, Kerry, Morris, Claudia R., Mintegi Raso, Santiago, Gangoiti, Iker, Sabhaney, Vikram J., Plint, Amy C., Klassen, Terry P., Avva, Usha R., Shah, Nipam P., Dixon, Andrew C., Lunoe, Maren M., Becker, Sarah M., Rogers, Alexander J., Pavlicich, Viviana, Dalziel, Stuart R., Payne, Daniel C., Malley, Richard, Borland, Meredith L., Morrison, Andrea K., Bhatt, Maala, Rino, Pedro B., Beneyto Ferre, Isabel, Eckerle, Michelle, Kam, April J., Chong, Shu-Ling, Palumbo, Laura, Kwok, Maria Y., Cherry, Jonathan C., Poonai, Naveen, Waseem, MD; Norma-Jean Simon, MPH, Waseem, Muhammad, Simon, Norma-Jean, Freedman, Stephen B., and Pediatric Emergency Research Network–COVID-19 Study Team

Abstract

IMPORTANCE Little is known about the risk factors for, and the risk of, developing post-COVID-19 conditions (PCCs) among children. OBJECTIVES To estimate the proportion of SARS-CoV-2-positive children with PCCs 90 days after a positive test result, to compare this proportion with SARS-CoV-2-negative children, and to assess factors associated with PCCs. DESIGN, SETTING, AND PARTICIPANTS This prospective cohort study, conducted in 36 emergency departments (EDs) in 8 countries between March 7, 2020, and January 20, 2021, included 1884 SARS-CoV-2-positive children who completed 90-day follow-up; 1686 of these children were frequency matched by hospitalization status, country, and recruitment date with 1701 SARS-CoV-2-negative controls. EXPOSURE SARS-CoV-2 detected via nucleic acid testing. MAIN OUTCOMES AND MEASURES Post-COVID-19 conditions, defined as any persistent, new, or recurrent health problems reported in the 90-day follow-up survey. RESULTS Of 8642 enrolled children, 2368 (27.4%) were SARS-CoV-2 positive, among whom 2365 (99.9%) had index ED visit disposition data available; among the 1884 children (79.7%) who completed follow-up, the median age was 3 years (IQR, 0-10 years) and 994 (52.8%) were boys. A total of 110 SARS-CoV-2-positive children (5.8%; 95% CI, 4.8%-7.0%) reported PCCs, including 44 of 447 children (9.8%; 95% CI, 7.4%-13.0%) hospitalized during the acute illness and 66 of 1437 children (4.6%; 95% CI, 3.6%-5.8%) not hospitalized during the acute illness (difference. 5.3%; 95% CI, 2.5%-8.5%). Among SARS-CoV-2-positive children, the most common symptom was fatigue or weakness (21 [1.1%]). Characteristics associated with reporting at least 1 PCC at 90 days included being hospitalized 48 hours or more compared with no hospitalization (adjusted odds ratio [aOR], 2.67 [95% CI, 1.63-4.38]); having 4 or more symptoms reported at the index ED visit compared with 1 to 3 symptoms (4-6 symptoms: aOR, 2.35 [95% CI, 1.28-4.31]; >= 7 symptoms: aOR, 4.59 [95% CI

Published
2022

49. B cell–intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice

Author

Recher, Mike, Burns, Siobhan O., de la Fuente, Miguel A., Volpi, Stefano, Dahlberg, Carin, Walter, Jolan E., Moffitt, Kristin, Mathew, Divij, Honke, Nadine, Lang, Philipp A., Patrizi, Laura, Falet, Hervé, Keszei, Marton, Mizui, Masayuki, Csizmadia, Eva, Candotti, Fabio, Nadeau, Kari, Bouma, Gerben, Delmonte, Ottavia M., Frugoni, Francesco, Fomin, Angela B. Ferraz, Buchbinder, David, Lundequist, Emma Maria, Massaad, Michel J., Tsokos, George C., Hartwig, John, Manis, John, Terhorst, Cox, Geha, Raif S., Snapper, Scott, Lang, Karl S., Malley, Richard, Westerberg, Lisa, Thrasher, Adrian J., and Notarangelo, Luigi D.

Published
2012
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50. Household transmission of SARS-CoV-2 from unvaccinated asymptomatic and symptomatic household members with confirmed SARS-CoV-2 infection: an antibody-surveillance study

Author

Bhatt, Maala, primary, Plint, Amy C., additional, Tang, Ken, additional, Malley, Richard, additional, Huy, Anne Pham, additional, McGahern, Candice, additional, Dawson, Jennifer, additional, Pelchat, Martin, additional, Dawson, Lauren, additional, Varshney, Terry, additional, Arnold, Corey, additional, Galipeau, Yannick, additional, Austin, Michael, additional, Thampi, Nisha, additional, Alnaji, Fuad, additional, Langlois, Marc-André, additional, and Zemek, Roger L., additional

Published
2022
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