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1. World guidelines for falls prevention and management for older adults: a global initiative

Author

Montero-Odasso, Manuel, van der Velde, Nathalie, Martin, Finbarr C, Petrovic, Mirko, Tan, Maw Pin, Ryg, Jesper, Aguilar-Navarro, Sara, Alexander, Neil B, Becker, Clemens, Blain, Hubert, Bourke, Robbie, Cameron, Ian D, Camicioli, Richard, Clemson, Lindy, Close, Jacqueline, Delbaere, Kim, Duan, Leilei, Duque, Gustavo, Dyer, Suzanne M, Freiberger, Ellen, Ganz, David A, Gómez, Fernando, Hausdorff, Jeffrey M, Hogan, David B, Hunter, Susan MW, Jauregui, Jose R, Kamkar, Nellie, Kenny, Rose-Anne, Lamb, Sarah E, Latham, Nancy K, Lipsitz, Lewis A, Liu-Ambrose, Teresa, Logan, Pip, Lord, Stephen R, Mallet, Louise, Marsh, David, Milisen, Koen, Moctezuma-Gallegos, Rogelio, Morris, Meg E, Nieuwboer, Alice, Perracini, Monica R, Pieruccini-Faria, Frederico, Pighills, Alison, Said, Catherine, Sejdic, Ervin, Sherrington, Catherine, Skelton, Dawn A, Dsouza, Sabestina, Speechley, Mark, Stark, Susan, Todd, Chris, Troen, Bruce R, van der Cammen, Tischa, Verghese, Joe, Vlaeyen, Ellen, Watt, Jennifer A, Masud, Tahir, Singh, Devinder Kaur Ajit, Aguilar-Navarro, Sara G, Caona, Edgar Aguilera, Allen, Natalie, Anweiller, Cedric, Avila-Funes, Alberto, Santos, Renato Barbosa, Batchelor, Francis, Beauchamp, Marla, Birimoglu, Canan, Bohlke, Kayla, Bourke, Robert, Bouzòn, Christina Alonzo, Bridenbaugh, Stephanie, Buendia, Patricio Gabriel, Cameron, Ian, Canning, Colleen, Cano-Gutierrez, Carlos Alberto, Carbajal, Juan Carlos, de Abreu, Daniela Cristina Carvalho, Casas-Herrero, Alvaro, Ceriani, Alejandro, Cesari, Matteo, Chiari, Lorenzo, Alemǻn, Luis Manuel Cornejo, Dawson, Rik, Doody, Paul, Dyer, Suzanne, Ellmers, Toby, Fairhall, Nicola, Ferruci, Luigi, and Frith, James

Subjects
Biomedical and Clinical Sciences, Health Services and Systems, Public Health, Health Sciences, Clinical Sciences, Aging, Prevention, Clinical Research, Patient Safety, Physical Injury - Accidents and Adverse Effects, Health and social care services research, 8.1 Organisation and delivery of services, 7.1 Individual care needs, Management of diseases and conditions, Good Health and Well Being, Aged, Caregivers, Humans, Independent Living, Quality of Life, Risk Assessment, falls, injury, aged, guidelines, recommendations, clinical practice, world, global, consensus, older people, Task Force on Global Guidelines for Falls in Older Adults, Public Health and Health Services, Psychology, Geriatrics, Clinical sciences, Health services and systems, Applied and developmental psychology
Abstract

Backgroundfalls and fall-related injuries are common in older adults, have negative effects on functional independence and quality of life and are associated with increased morbidity, mortality and health related costs. Current guidelines are inconsistent, with no up-to-date, globally applicable ones present.Objectivesto create a set of evidence- and expert consensus-based falls prevention and management recommendations applicable to older adults for use by healthcare and other professionals that consider: (i) a person-centred approach that includes the perspectives of older adults with lived experience, caregivers and other stakeholders; (ii) gaps in previous guidelines; (iii) recent developments in e-health and (iv) implementation across locations with limited access to resources such as low- and middle-income countries.Methodsa steering committee and a worldwide multidisciplinary group of experts and stakeholders, including older adults, were assembled. Geriatrics and gerontological societies were represented. Using a modified Delphi process, recommendations from 11 topic-specific working groups (WGs), 10 ad-hoc WGs and a WG dealing with the perspectives of older adults were reviewed and refined. The final recommendations were determined by voting.Recommendationsall older adults should be advised on falls prevention and physical activity. Opportunistic case finding for falls risk is recommended for community-dwelling older adults. Those considered at high risk should be offered a comprehensive multifactorial falls risk assessment with a view to co-design and implement personalised multidomain interventions. Other recommendations cover details of assessment and intervention components and combinations, and recommendations for specific settings and populations.Conclusionsthe core set of recommendations provided will require flexible implementation strategies that consider both local context and resources.

Published
2022

10. Introduction

Author

Huang, Allen R., Mallet, Louise, Huang, Allen R., editor, and Mallet, Louise, editor

Published
2016
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12. Compliance with best practice guidelines on publication ethics : where does pharmactuel stand? A case study

Author

Hamel, Christine, Méthot, Julie, Mallet, Louise, Hamel, Christine, Méthot, Julie, and Mallet, Louise

Abstract

Background: The Committee on Publication Ethics (COPE) and the International Committee of Medical Journal Editors (ICMJE) are two internationally recognised organisations in the field of publication ethics. Guidelines from these two organisations were updated in 2018. Objectives: To assess the extent to which the journal Pharmactuel is compliant with the guidelines on publication ethics updated by ICMJE and COPE in 2018 and, where the journal is found wanting, to take the necessary steps to make it compliant. Methods: A list of updated criteria – 56 by ICMJE and 22 by COPE – was compiled. In January 2020, compliance with each of these criteria was evaluated by the editor-in-chief and validated by all six associate editors. The evaluation was followed by an action plan to improve compliance, and the evaluation was repeated in November 2020. Results: Of the 56 ICMJE criteria, Pharmactuel was fully compliant with 31 and partly compliant with 10 criteria (a compliance rate of 73%, taking the two together). The corresponding figures for the 22 COPE criteria were 17, 3, and 91%. By modifying its editorial policies, training its associate editors, and creating appropriate guidelines for its editorial board and editors, Pharmactuel achieved almost 100% compliance by the end of 2020. Conclusions: Pharmactuel has been fully compliant with ICMJE and COPE recommendations since January 2021. Minor modifications to Pharmactuel’s publication process have enabled the editorial team to ensure that the journal continues to be almost totally compliant with COPE and ICMJE guidelines and to uphold its high ethical standards.

Published
2023

14. Medication reviews and deprescribing as a single intervention in falls prevention: a systematic review and meta-analysis

Author

Seppala, Lotta J., Kamkar, Nellie, van Poelgeest, Eveline P., Thomsen, Katja, Daams, Joost G., Ryg, Jesper, Masud, Tahir, Montero-Odasso, Manuel, Hartikainen, Sirpa, Petrovic, Mirko, van der Velde, Nathalie, Nieuwboer, Alice, Vlaeyen, Ellen, Milisen, Koen, Kenny, Rose Anne, Bourke, Robert, van der Cammen, Tischa, Poelgeest, Eveline, Jellema, Anton, Todd, Chris, Martin, Finbarr C., Marsh, David R., Lamb, Sallie, Frith, James, Logan, Pip, Skelton, Dawn, Blain, Hubert, Anweiller, Cedric, Freiberger, Ellen, Becker, Clemens, Chiari, Lorenzo, Cesari, Matteo, Casas-Herrero, Alvaro, Perez Jara, Javier, Alonzo Bouzòn, Christina, Welmer, Ana-Karim, Birnghebuam, Stephanie, Kressig, Reto, Speechley, Mark, Mcilroy, Bill, Faria, Frederico, Sultana, Munira, Muir-Hunter, Susan, Camicioli, Richard, Madden, Kenneth, Norris, Mireille, Watt, Jennifer, Mallet, Louise, Hogan, David, Verghese, Joe, Sejdic, Ervin, Ferruci, Luigi, Lipsitz, Lewis, Ganz, David A., Alexander, Neil B., Latham, Nancy Kathryn, Giber, Fabiana, Schapira, Marcelo, Jauregui, Ricardo, Melgar-Cuellar, Felipe, Alves Lourenço, Roberto, Carvalho de Abreu, Daniela Cristina, Perracini, Monica, Ceriani, Alejandro, Marín-Larraín, Pedro, Espinola, Homero Gac, Gómez-Montes, Jose Fernando, Cano-Gutierrez, Carlos Alberto, Ulate, Xinia Ramirez, Picado Ovares, Jose Ernesto, Gabriel Buendia, Patricio, Tito, Susana Lucia, Padilla, Diego Martínez, Aguilar-Navarro, Sara G., Mimenza, Alberto, Moctezum, Rogelio, Avila-Funes, Alberto, Gutierrez-Robledo, Luis Miguel, Cornejo Alemán, Luis Manuel, Caona, Edgar Aguilera, Carbajal, Juan Carlos, Parodi, Jose F., Sgaravatti, Aldo, Lord, Stephen, Sherrington, Cathie, Said, Cathy, Cameron, Ian, Morris, Meg, Duque, Gustavo, Close, Jacqueline, Kerse, Ngaire, Tan, Maw Pin, Duan, Leilei, Sakurai, Ryota, Wong, Chek Hooi, Muneeb, Irfan, Negahban, Hossein, Birimoglu, Canan, Won, Chang Won, Huasdorff, Jeffrey, Kalula, Sebastiana, Kobusingye, Olive, Geriatrics, APH - Aging & Later Life, Medical Library, and AMS - Ageing & Vitality

Subjects
Aging, Medication Review, General Medicine, Hospitals, fall-risk-increasing drugs, older people, Deprescriptions, deprescribing, systematic review, Medicine and Health Sciences, Humans, accidental falls, medication review, Geriatrics and Gerontology, Exercise
Abstract

Background our aim was to assess the effectiveness of medication review and deprescribing interventions as a single intervention in falls prevention. Methods Design systematic review and meta-analysis. Data sources Medline, Embase, Cochrane CENTRAL, PsycINFO until 28 March 2022. Eligibility criteria randomised controlled trials of older participants comparing any medication review or deprescribing intervention with usual care and reporting falls as an outcome. Study records title/abstract and full-text screening by two reviewers. Risk of bias Cochrane Collaboration revised tool. Data synthesis results reported separately for different settings and sufficiently comparable studies meta-analysed. Results forty-nine heterogeneous studies were included. Community meta-analyses of medication reviews resulted in a risk ratio (RR) of 1.05 (95% confidence interval, 0.85–1.29, I2 = 0%, 3 studies(s)) for number of fallers, in an RR = 0.95 (0.70–1.27, I2 = 37%, 3 s) for number of injurious fallers and in a rate ratio (RaR) of 0.89 (0.69–1.14, I2 = 0%, 2 s) for injurious falls. Hospital meta-analyses assessing medication reviews resulted in an RR = 0.97 (0.74–1.28, I2 = 15%, 2 s) and in an RR = 0.50 (0.07–3.50, I2 = 72% %, 2 s) for number of fallers after and during admission, respectively. Long-term care meta-analyses investigating medication reviews or deprescribing plans resulted in an RR = 0.86 (0.72–1.02, I2 = 0%, 5 s) for number of fallers and in an RaR = 0.93 (0.64–1.35, I2 = 92%, 7 s) for number of falls. Conclusions the heterogeneity of the interventions precluded us to estimate the exact effect of medication review and deprescribing as a single intervention. For future studies, more comparability is warranted. These interventions should not be implemented as a stand-alone strategy in falls prevention but included in multimodal strategies due to the multifactorial nature of falls. PROSPERO registration number: CRD42020218231

Published
2022
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16. World guidelines for falls prevention and management for older adults:a global initiative

Author

Montero-Odasso, Manuel, van der Velde, Nathalie, Martin, Finbarr C., Petrovic, Mirko, Tan, Maw Pin, Ryg, Jesper, Aguilar-Navarro, Sara, Alexander, Neil B., Becker, Clemens, Blain, Hubert, Bourke, Robbie, Cameron, Ian D., Camicioli, Richard, Clemson, Lindy, Close, Jacqueline, Delbaere, Kim, Duan, Leilei, Duque, Gustavo, Dyer, Suzanne M., Freiberger, Ellen, Ganz, David A., Gómez, Fernando, Hausdorff, Jeffrey M., Hogan, David B., Hunter, Susan M.W., Jauregui, Jose R., Kamkar, Nellie, Kenny, Rose Anne, Lamb, Sarah E., Latham, Nancy K., Lipsitz, Lewis A., Liu-Ambrose, Teresa, Logan, Pip, Lord, Stephen R., Mallet, Louise, Marsh, David, Milisen, Koen, Moctezuma-Gallegos, Rogelio, Morris, Meg E., Nieuwboer, Alice, Perracini, Monica R., Pieruccini-Faria, Frederico, Pighills, Alison, Said, Catherine, Sejdic, Ervin, Sherrington, Catherine, Skelton, Dawn A., Dsouza, Sabestina, Speechley, Mark, van der Cammen, Tischa, Watt, Jennifer, Masud, T, Montero-Odasso, Manuel, van der Velde, Nathalie, Martin, Finbarr C., Petrovic, Mirko, Tan, Maw Pin, Ryg, Jesper, Aguilar-Navarro, Sara, Alexander, Neil B., Becker, Clemens, Blain, Hubert, Bourke, Robbie, Cameron, Ian D., Camicioli, Richard, Clemson, Lindy, Close, Jacqueline, Delbaere, Kim, Duan, Leilei, Duque, Gustavo, Dyer, Suzanne M., Freiberger, Ellen, Ganz, David A., Gómez, Fernando, Hausdorff, Jeffrey M., Hogan, David B., Hunter, Susan M.W., Jauregui, Jose R., Kamkar, Nellie, Kenny, Rose Anne, Lamb, Sarah E., Latham, Nancy K., Lipsitz, Lewis A., Liu-Ambrose, Teresa, Logan, Pip, Lord, Stephen R., Mallet, Louise, Marsh, David, Milisen, Koen, Moctezuma-Gallegos, Rogelio, Morris, Meg E., Nieuwboer, Alice, Perracini, Monica R., Pieruccini-Faria, Frederico, Pighills, Alison, Said, Catherine, Sejdic, Ervin, Sherrington, Catherine, Skelton, Dawn A., Dsouza, Sabestina, Speechley, Mark, van der Cammen, Tischa, Watt, Jennifer, and Masud, T

Abstract

BACKGROUND: falls and fall-related injuries are common in older adults, have negative effects on functional independence and quality of life and are associated with increased morbidity, mortality and health related costs. Current guidelines are inconsistent, with no up-to-date, globally applicable ones present. OBJECTIVES: to create a set of evidence- and expert consensus-based falls prevention and management recommendations applicable to older adults for use by healthcare and other professionals that consider: (i) a person-centred approach that includes the perspectives of older adults with lived experience, caregivers and other stakeholders; (ii) gaps in previous guidelines; (iii) recent developments in e-health and (iv) implementation across locations with limited access to resources such as low- and middle-income countries. METHODS: a steering committee and a worldwide multidisciplinary group of experts and stakeholders, including older adults, were assembled. Geriatrics and gerontological societies were represented. Using a modified Delphi process, recommendations from 11 topic-specific working groups (WGs), 10 ad-hoc WGs and a WG dealing with the perspectives of older adults were reviewed and refined. The final recommendations were determined by voting. RECOMMENDATIONS: all older adults should be advised on falls prevention and physical activity. Opportunistic case finding for falls risk is recommended for community-dwelling older adults. Those considered at high risk should be offered a comprehensive multifactorial falls risk assessment with a view to co-design and implement personalised multidomain interventions. Other recommendations cover details of assessment and intervention components and combinations, and recommendations for specific settings and populations. CONCLUSIONS: the core set of recommendations provided will require flexible implementation strategies that consider both local context and resources.

Published
2022

19. Evaluation of Clinical Practice Guidelines on Fall Prevention and Management for Older Adults: A Systematic Review

Author

Alice, Nieuwboer, Vlaeyen, Ellen, Milisen, Koen, Bourke, Robert, Hartikainen, Sirpa, Van der Cammen, Tischa, Todd, Chris, Martin, Finbarr C, Marsh, David R, Frith, James, Logan, Pip, Skelton, Dawn, Blain, Hubert, Anweiller, Cedric, Freiberger, Ellen, Clemens And Becker, Cesari, Matteo, Casas-Herrero, Alvaro, Bouzòn, Christina Alonzo, Welmer, Ana-Karim, Birnghebuam, Stephanie, Kressig, Reto, Montero-Odasso, Manuel, McIlroy, Bill, Camicioli, Richard, Norris, Mireille, Watt, Jennifer, Mallet, Louise, Hogan, David B, Ervin, Sejdic, Ferruci, Luigi, Ganz, David A, Alexander, Neil B, Giber, Fabiana, Schapira, Marcelo, Jauregui, Ricardo, Melgar-Cuellar, Felipe, de Abreu, Daniela Cristina Carvalho, Lourenço, Roberto Alves, Pierrucini, Monica, Ceriani, Alejandro, Marín-Larraín, Pedro, Gómez-Montes, José Fernando, Cano-Gutierrez, Carlos Alberto, Ulate, Xinia Ramirez, Ovares, José Ernesto Picado, Buendia, Patricio Gabriel, Tito, Susana Lucia, Padilla, Diego Martínez, Aguilar-Navarro, Sara G, Mimenza, Alberto, Moctezum, Rogelio, Avila-Funes, Alberto, Gutiérrez-Robledo, Luis Miguel, Alemán, Luis Manuel Cornejo, Caona, Edgar Aguilera, Carbajal, Juan Carlos, Parodi, José F, Sgaravatti, Aldo, Sherrington, Cathie, Said, Cathy, Cameron, Ian, Morris, Meg, Duque, Gustavo, Kerse, Ngaire, Duan, Leilei, Sakurai, Ryota, Wong, Chek Hooi, Negahban, Hossein, Won, Chang Won, Hausdorff, Jeffrey, Kalula, Sebastiana, and Kobusingye, Olive

Subjects
Uncategorized
Abstract

Importance: With the global population aging, falls and fall-related injuries are ubiquitous, and several clinical practice guidelines for falls prevention and management for individuals 60 years or older have been developed. A systematic evaluation of the recommendations and agreement level is lacking. Objectives: To perform a systematic review of clinical practice guidelines for falls prevention and management for adults 60 years or older in all settings (eg, community, acute care, and nursing homes), evaluate agreement in recommendations, and identify potential gaps. Evidence Review: A systematic review following Preferred Reporting Items for Systematic Reviews and Meta-analyses statement methods for clinical practice guidelines on fall prevention and management for older adults was conducted (updated July 1, 2021) using MEDLINE, PubMed, PsycINFO, Embase, CINAHL, the Cochrane Library, PEDro, and Epistemonikos databases. Medical Subject Headings search terms were related to falls, clinical practice guidelines, management and prevention, and older adults, with no restrictions on date, language, or setting for inclusion. Three independent reviewers selected records for full-text examination if they followed evidence- and consensus-based processes and assessed the quality of the guidelines using Appraisal of Guidelines for Research & Evaluation II (AGREE-II) criteria. The strength of the recommendations was evaluated using Grades of Recommendation, Assessment, Development, and Evaluation scores, and agreement across topic areas was assessed using the Fleiss κ statistic. Findings: Of 11 414 records identified, 159 were fully reviewed and assessed for eligibility, and 15 were included. All 15 selected guidelines had high-quality AGREE-II total scores (mean [SD], 80.1% [5.6%]), although individual quality domain scores for clinical applicability (mean [SD], 63.4% [11.4%]) and stakeholder (clinicians, patients, or caregivers) involvement (mean [SD], 76.3% [9.0%]) were lower. A total of 198 recommendations covering 16 topic areas in 15 guidelines were identified after screening 4767 abstracts that proceeded to 159 full texts. Most (≥11) guidelines strongly recommended performing risk stratification, assessment tests for gait and balance, fracture and osteoporosis management, multifactorial interventions, medication review, exercise promotion, environment modification, vision and footwear correction, referral to physiotherapy, and cardiovascular interventions. The strengths of the recommendations were inconsistent for vitamin D supplementation, addressing cognitive factors, and falls prevention education. Recommendations on use of hip protectors and digital technology or wearables were often missing. None of the examined guidelines included a patient or caregiver panel in their deliberations. Conclusions and Relevance: This systematic review found that current clinical practice guidelines on fall prevention and management for older adults showed a high degree of agreement in several areas in which strong recommendations were made, whereas other topic areas did not achieve this level of consensus or coverage. Future guidelines should address clinical applicability of their recommendations and include perspectives of patients and other stakeholders.

Published
2022
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20. Evaluation of Clinical Practice Guidelines on Fall Prevention and Management for Older Adults: A Systematic Review

Author

Montero-Odasso, Manuel M., Kamkar, Nellie, Pieruccini-Faria, Frederico, Osman, Abdelhady, Sarquis-Adamson, Yanina, Close, Jacqueline, Hogan, David B., Hunter, Susan Winifred, Kenny, Rose Anne, Lipsitz, Lewis A., Lord, Stephen R., Madden, Kenneth M., Petrovic, Mirko, Ryg, Jesper, Speechley, Mark, Sultana, Munira, Tan, Maw Pin, van der Velde, N., Verghese, Joe, Masud, Tahir, Nieuwboer, Alice, Vlaeyen, Ellen, Milisen, Koen, Bourke, Robert, Hartikainen, Sirpa, Van der Cammen, Tischa, Van der Velde, Nathalie, Todd, Chris, Martin, Finbarr C., Marsh, David R., Lamb, Sallie, Frith, James, Logan, Pip, Skelton, Dawn, Blain, Hubert, Anweiller, Cedric, Freiberger, Ellen, Becker, Clemens, Cesari, Matteo, Casas-Herrero, Alvaro, Jara, Javier Perez, Bouzòn, Christina Alonzo, Welmer, Ana-Karim, Birnghebuam, Stephanie, Kressig, Reto, Montero-Odasso, Manuel, McIlroy, Bill, Hunter, Susan, Camicioli, Richard, Madden, Kenneth, Norris, Mireille, Watt, Jennifer, Mallet, Louise, Sejdic, Ervin, Ferruci, Luigi, Lipsitz, Lewis, Ganz, David A., Alexander, Neil B., Giber, Fabiana, Schapira, Marcelo, Jauregui, Ricardo, Melgar-Cuellar, Felipe, Carvalho de Abreu, Daniela Cristina, Lourenço, Roberto Alves, Pierrucini, Monica, Ceriani, Alejandro, Marín-Larraín, Pedro, Gac Espinola, Homero, Gómez-Montes, José Fernando, Cano-Gutierrez, Carlos Alberto, Ramirez Ulate, Xinia, Picado Ovares, José Ernesto, Buendia, Patricio Gabriel, Tito, Susana Lucia, Martínez Padilla, Diego, Aguilar-Navarro, Sara G., Mimenza, Alberto, Moctezum, Rogelio, Avila-Funes, Alberto, Gutiérrez-Robledo, Luis Miguel, Cornejo Alemán, Luis Manuel, Aguilera Caona, Edgar, Carbajal, Juan Carlos, Parodi, José F., Sgaravatti, Aldo, Lord, Stephen, Sherrington, Cathie, Said, Cathy, Cameron, Ian, Morris, Meg, Duque, Gustavo, Kerse, Ngaire, Duan, Leilei, Sakurai, Ryota, Hooi Wong, Chek, Negahban, Hossein, Won Won, Chang, Hausdorff, Jeffrey, Kalula, Sebastiana, Kobusingye, Olive, Task Force on Global Guidelines for Falls in Older Adults, [missing], Elderly care medicine, Geriatrics, AMS - Ageing & Vitality, and APH - Aging & Later Life

Subjects
LONG-TERM, General Medicine, COGNITIVE IMPAIRMENT, DEPRESSION, RECOMMENDATIONS, COMMUNITY, prevention, systematic review, PEOPLE, BALANCE, falls, Medicine and Health Sciences, RISK-FACTORS, HEALTH, VITAMIN-D, clinical practice guidelines, management, older adults
Abstract

Importance: With the global population aging, falls and fall-related injuries are ubiquitous, and several clinical practice guidelines for falls prevention and management for individuals 60 years or older have been developed. A systematic evaluation of the recommendations and agreement level is lacking. Objectives: To perform a systematic review of clinical practice guidelines for falls prevention and management for adults 60 years or older in all settings (eg, community, acute care, and nursing homes), evaluate agreement in recommendations, and identify potential gaps. Evidence Review: A systematic review following Preferred Reporting Items for Systematic Reviews and Meta-analyses statement methods for clinical practice guidelines on fall prevention and management for older adults was conducted (updated July 1, 2021) using MEDLINE, PubMed, PsycINFO, Embase, CINAHL, the Cochrane Library, PEDro, and Epistemonikos databases. Medical Subject Headings search terms were related to falls, clinical practice guidelines, management and prevention, and older adults, with no restrictions on date, language, or setting for inclusion. Three independent reviewers selected records for full-text examination if they followed evidence- and consensus-based processes and assessed the quality of the guidelines using Appraisal of Guidelines for Research & Evaluation II (AGREE-II) criteria. The strength of the recommendations was evaluated using Grades of Recommendation, Assessment, Development, and Evaluation scores, and agreement across topic areas was assessed using the Fleiss κ statistic. Findings: Of 11414 records identified, 159 were fully reviewed and assessed for eligibility, and 15 were included. All 15 selected guidelines had high-quality AGREE-II total scores (mean [SD], 80.1% [5.6%]), although individual quality domain scores for clinical applicability (mean [SD], 63.4% [11.4%]) and stakeholder (clinicians, patients, or caregivers) involvement (mean [SD], 76.3% [9.0%]) were lower. A total of 198 recommendations covering 16 topic areas in 15 guidelines were identified after screening 4767 abstracts that proceeded to 159 full texts. Most (≥11) guidelines strongly recommended performing risk stratification, assessment tests for gait and balance, fracture and osteoporosis management, multifactorial interventions, medication review, exercise promotion, environment modification, vision and footwear correction, referral to physiotherapy, and cardiovascular interventions. The strengths of the recommendations were inconsistent for vitamin D supplementation, addressing cognitive factors, and falls prevention education. Recommendations on use of hip protectors and digital technology or wearables were often missing. None of the examined guidelines included a patient or caregiver panel in their deliberations. Conclusions and Relevance: This systematic review found that current clinical practice guidelines on fall prevention and management for older adults showed a high degree of agreement in several areas in which strong recommendations were made, whereas other topic areas did not achieve this level of consensus or coverage. Future guidelines should address clinical applicability of their recommendations and include perspectives of patients and other stakeholders..

Published
2021
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22. Compliance with best practice guidelines on publication ethics: Where does Pharmactuel stand? A case study

Author

Hamel, Christine, Méthot, Julie, and Mallet, Louise

Subjects
publication ethics, ICMJE, instructions to authors, Pharmactuel, COPE, editorial policies, Compliance
Abstract

Background: The Committee on Publication Ethics (COPE) and the International Committee of Medical Journal Editors (ICMJE) are two internationally recognised organisations in the field of publication ethics. Guidelines from these two organisations were updated in 2018.Objectives: To assess the extent to which the journal Pharmactuel is compliant with the guidelines on publication ethics updated by ICMJE and COPE in 2018 and, where the journal is found wanting, to take the necessary steps to make it compliant.Methods: A list of updated criteria – 56 by ICMJE and 22 by COPE – was compiled. In January 2020, compliance with each of these criteria was evaluated by the editor-in-chief and validated by all six associate editors. The evaluation was followed by an action plan to improve compliance, and the evaluation was repeated in November 2020.Results: Of the 56 ICMJE criteria, Pharmactuel was fully compliant with 31 and partly compliant with 10 criteria (a compliance rate of 73%, taking the two together). The corresponding figures for the 22 COPE criteria were 17, 3, and 91%. By modifying its editorial policies, training its associate editors, and creating appropriate guidelines for its editorial board and editors, Pharmactuel achieved almost 100% compliance by the end of 2020.Conclusions: Pharmactuel has been fully compliant with ICMJE and COPE recommendations since January 2021. Minor modifications to Pharmactuel’s publication process have enabled the editorial team to ensure that the journal continues to be almost totally compliant with COPE and ICMJE guidelines and to uphold its high ethical standards.

Published
2021

23. Pharmacist‐led transitions of care between hospitals, primary care clinics, and community pharmacies

Author

Cossette, Benoit, primary, Ricard, Geneviève, additional, Poirier, Rolande, additional, Gosselin, Suzanne, additional, Langlois, Marie‐France, additional, Imbeault, Philippe, additional, Breton, Mylaine, additional, Couturier, Yves, additional, Sirois, Caroline, additional, Lessard‐Beaudoin, Mélissa, additional, Rodrigue, Claudie, additional, Teasdale, Julie, additional, Turcotte, Jean‐Philippe, additional, and Mallet, Louise, additional

Published
2021
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27. Olanzapine prolongs cardiac repolarization by blocking the rapid component of the delayed rectifier potassium current

Author

Morissette, Pierre, Hreiche, Raymond, Mallet, Louise, Vo, Dean, Knaus, Edward E., and Turgeon, Jacques

Subjects
Heart beat -- Observations -- Chemical properties -- Electric properties, Olanzapine -- Complications and side effects -- Electric properties -- Chemical properties, Arrhythmia -- Risk factors -- Complications and side effects, Pharmaceuticals and cosmetics industries, Psychology and mental health, Observations, Complications and side effects, Chemical properties, Risk factors, Electric properties
Abstract

Prolongation of the QT interval has been observed during treatment with olanzapine, a thienobenzodiazepine antipsychotic agent. Our objectives were 1) to characterize the effects of olanzapine on cardiac repolarization and 2) to evaluate effects of olanzapine on the major time-dependent outward potassium current involved in cardiac repolarization, namely [I.sub.Kr] ([I.sub.Kr]: rapid component of the delayed rectifier potassium current). Isolated, buffer-perfused guinea pig hearts (n = 40) were stimulated at different pacing cycle lengths (150-250 msec) and exposed to olanzapine at concentrations ranging from 1 to 100 µM. Olanzapine increased monophasic action potential duration measured at 90% repolarization (MAP[D.sub.90]) in a concentration-dependent manner by 6.7 ± 0.7 msec at 3µM but by 26.0 ± 4.3 msec at 100 µM (250 msec cycle length). Increase in MAP[D.sub.90] was also reverse frequency dependent; 30 µM olanzapine increased MAP[D.sub.90] by 28.0 ± 6.2 msec at a pacing cycle length of 250 msec but by only 18.9 ± 2.2 msec at a pacing cycle length of 150 msec. Experiments in HERG-transfected (HERG: human ether-a-gogo-related gene) HEK293 cells (n = 36) demonstrated concentration-dependent block of the rapid component ([I.sub.Kr]) of the delayed rectifier potassium current: tail current was decreased 50% at olanzapine 3.8µM. Olanzapine possesses direct cardiac electrophysiological effects similar to those of class III anti-arrhythmic drugs. These effects were observed at concentrations that can be measured in patients under conditions of impaired drug elimination such as renal or hepatic insufficiency, during co-administration of other CYP1A2 substrates/inhibitors or after drug overdose. These results offer a new potential explanation for QT prolonging effects observed during olanzapine treatment in patients. Keywords antipsychotics, drug-induced long QT syndrome, potassium channel, torsades de pointes, arrhythmia, Introduction Olanzapine is an atypical antipsychotic of the thienobenzodiazepine class that shows high affinity for the serotonin 5-H[T.sub.2A/C] receptor. Although structurally and functionally related to clozapine, it possesses a more [...]

Published
2007

28. Pharmacist-led transitions of care for older adults at risk of drug-related problems : a feasibility study

Author

Cossette, Benoit, Ricard, Geneviève, Poirier, Rolande, Gosselin, Suzanne, Langlois, Marie-France, Breton, Mylaine, Sirois, Caroline, Rodrigue, Claudie, Lessard-Beaudoin, Mélissa, Teasdale, Julie, Piché, Benjamin, Khalilipalandi, Sara, Trottier, Lise, Mallet, Louise, Cossette, Benoit, Ricard, Geneviève, Poirier, Rolande, Gosselin, Suzanne, Langlois, Marie-France, Breton, Mylaine, Sirois, Caroline, Rodrigue, Claudie, Lessard-Beaudoin, Mélissa, Teasdale, Julie, Piché, Benjamin, Khalilipalandi, Sara, Trottier, Lise, and Mallet, Louise

Abstract

Background: Transitions of care (TOC) is one of three key action areas identified in the World Health Organization (WHO)’s third Global Patient Safety Challenge, Medication Without Harm, released in 2017. Systematic reviews have shown that TOC interventions can improve health outcomes, although few studies have evaluated the role of the community pharmacist. Objective: To evaluate the feasibility of a pharmacist-led TOC intervention for older adults at risk of drug-related problems. Methods: Pragmatic feasibility study conducted in hospital and community pharmacies in a health region of Quebec, Canada. The interventions consisted of a pharmaceutical care plan developed by the hospital pharmacist and transferred at hospital discharge to the patients’ community pharmacist, who completed patient consultations in the week following discharge and monthly for six months thereafter. Feasibility evaluations included recruitment, retention, time required, types of interventions, and modified classes of medications, based on clinical data entered in an electronic health record accessible to clinicians in all settings. Results: Of the 90 recruited patients, 76 were discharged with a pharmaceutical care plan. The mean age of these 76 subjects was 79.5 years, and 52.6% were female. The most frequent inclusion criteria were 15 or more medications (57.9%), two or more emergency department visits (past three months), or one or more hospitalization (past twelve months) (42.1%). The hospital pharmacist interventions took a mean time of 222 min. The community pharmacist interventions took a mean time of 52 min and 32 min for the first and subsequent visits, respectively. Therapeutic goals were documented for 60.5% of patients. Conclusions: This study shows the feasibility of implementing a pharmacist-led TOC intervention in the Canadian context. Development of the TOC model in three health regions is currently being pursued along with the inclusion of primary care clinics who recently

Published
2020

30. Les auteurs

Author

Allenet, Benoît, primary, Al Hajj-Karnib, Amal, additional, Angoulvant, Denis, additional, Antignac, Marie, additional, Armoiry, Xavier, additional, Aulagner, Gilles, additional, Baguet, Jean-Philippe, additional, Barreteau, Hélène, additional, Baudrant, Magalie, additional, Bedouch, Pierrick, additional, Bertrand, Marie-Anne, additional, Bolon-Larger, Magali, additional, Bonaz, Bruno, additional, Bonnefoy, Éric, additional, Boulieu, Roselyne, additional, Boyer-Grand, Anne, additional, Brazier, Michel, additional, Brudieu, Étienne, additional, Brunet, Philippe, additional, Buyse, Marion, additional, Calop, Jean, additional, Calop, Nathalie, additional, Caron, Philippe, additional, Cassat, Claude, additional, Cavicchi, Maryan, additional, Chapuis, Claire, additional, Chaumard, Natacha, additional, Chopineau, Jean, additional, Claerbout, Jean-François, additional, Clerc, Bertrand, additional, Contreras, Rémy, additional, Décaudin, Bertrand, additional, Desbiez, Françoise, additional, Desplaces, Nicole, additional, Dine, Thierry, additional, Djian, Cécile, additional, Derouesné, Christian, additional, Desablens, Françoise, additional, Dode, Xavier, additional, Ducharme, Murray P., additional, Dupuis, Antoine, additional, Fardellone, Patrice, additional, Farinotti, Robert, additional, Faure, Pierre, additional, Federspiel, Isabelle, additional, Fernandez, Christine, additional, Ferreira, Ema, additional, Francois, Éric, additional, Franchon, Émilie, additional, Germain, Emmanuel, additional, Gourdier, Bertrand, additional, Goujard, Cécile, additional, Grellet, Jean, additional, Guichard, Sylvie, additional, Hadri, Nassira, additional, Hulin, Anne, additional, Kaulek-Westeel, Virginie, additional, Laederich, Joëlle, additional, Lebargy, François, additional, Legat-Fagnoni, Christine, additional, Leverge, Roger, additional, Limat, Samuel, additional, Lok, Catherine, additional, Luyckx, Michel, additional, Madelaine, Isabelle, additional, Mailhot, Claude, additional, Mallet, Louise, additional, Marteau, Philippe, additional, Massias, Laurent, additional, Medjoub, Mehdi, additional, Mornex, Jean-François, additional, Odou, Pascal, additional, Pharand, Chantal, additional, Ragon, Alain, additional, Raignoux, Cécile, additional, Ratsimbazafy, Voa, additional, Rey, Chrystelle, additional, Richard, Denis, additional, Robert, Hugues, additional, Roulet, Lucien, additional, Sallerin, Brigitte, additional, Sautou-Miranda, Valérie, additional, Saux, Marie-Claude, additional, Senon, Jean-Louis, additional, Singlas, Éric, additional, Somda, Frédéric, additional, Steinmetz, Jean-Philippe, additional, Sylvoz, Nathalie, additional, Taburet, Anne-Marie, additional, Tacco, Frédéric, additional, Talbert, Marc, additional, Tauveron, Igor, additional, Thirion, Daniel J.G., additional, Thuong-Guyot, Marie, additional, Trivin, Caroline, additional, Venisse, Nicolas, additional, Vincent, Isabelle, additional, Williamson, David, additional, Wolff, Michel, additional, and Woronoff-Lemsi, Marie-Christine, additional

Published
2008
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33. Pharmacist‐led transitions of care between hospitals, primary care clinics, and community pharmacies.

Author

Cossette, Benoit, Ricard, Geneviève, Poirier, Rolande, Gosselin, Suzanne, Langlois, Marie‐France, Imbeault, Philippe, Breton, Mylaine, Couturier, Yves, Sirois, Caroline, Lessard‐Beaudoin, Mélissa, Rodrigue, Claudie, Teasdale, Julie, Turcotte, Jean‐Philippe, and Mallet, Louise

Subjects
OLDER patients, PREVENTION of drug side effects, HOSPITALS, PILOT projects, RESEARCH, OCCUPATIONAL roles, CONFIDENCE intervals, TRANSITIONAL care, DRUGSTORES, TIME, COMMUNITY health services, PRIMARY health care, MEDICATION therapy management, HOSPITAL pharmacies, HEALTH care teams, DESCRIPTIVE statistics, DATA analysis software, LONGITUDINAL method, OLD age
Abstract

Background: Pharmacist‐led transitions of care (TOC) interventions have been described as some of the most promising interventions to reduce medication‐related harm (MRH) in older adults. This study analyzed the feasibility of pharmacist‐led TOC interventions between hospitals, multidisciplinary primary care clinics (PCC), and community pharmacies. Methods: Adults aged 65 years and older at risk of MRH in three regions of Quebec, Canada, with contrasting contexts of care based on university affiliation were recruited in this multicenter, single arm, and prospective intervention cohort. The hospital pharmacist developed the pharmaceutical care plan in collaboration with the hospital physician and transferred this plan with the hospitalization summary, at hospital discharge, to the PCC family physician and to the community and PCC pharmacists. A consultation with the community pharmacist was scheduled within seven days of hospital discharge and with the PCC pharmacist when appropriate. Feasibility outcomes included the time to complete the interventions and their location. Results: The 123 eligible patients had a mean age of 78.5 years, and 63.4% were females. The most frequent inclusion criterion was 10 medications or more, including one high‐risk medication for 90 patients (73%). Recruitment in one region was stopped after three months due to unsuccessful recruitment of key PCC. The hospital pharmacist interventions took a median of 165 min. The first consultations of the PCC and community pharmacists took a median of 15 and 50 min. Among the 96 patients with a post‐discharge pharmacist follow‐up, 23 (24.0%) had a consultation with a PCC pharmacist, with 65.2% of the consultations conducted at the PCC. The community pharmacists conducted a consultation with 88 patients (93%), with more than 70% of consultations conducted by phone. Conclusion: Our study showed the feasibility of pharmacist‐led TOC interventions between hospitals, PCC, and community pharmacies and detailed the novel role that PCC pharmacists played in optimizing TOC interventions. [ABSTRACT FROM AUTHOR]

Published
2022
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37. New horizons in falls prevention and management for older adults: a global initiative.

Author

Montero-Odasso, Manuel, van der Velde, Nathalie, Alexander, Neil B, Becker, Clemens, Blain, Hubert, Camicioli, Richard, Close, Jacqueline, Duan, Leilei, Duque, Gustavo, Ganz, David A, Gómez, Fernando, Hausdorff, Jeffrey M, Hogan, David B, Jauregui, Jose R, Kenny, Rose Anne, Lipsitz, Lewis A, Logan, Pip A, Lord, Stephen R, Mallet, Louise, and Marsh, David R

Subjects
PREVENTION of injury, CONSENSUS (Social sciences), COMMITTEES, MORTALITY, STAKEHOLDER analysis, DISEASES, MEDICAL care costs, MEDICAL protocols, CONCEPTUAL structures, ACCIDENTAL falls, AGING, HEALTH care teams, MANAGEMENT, DELPHI method
Abstract

Background falls and fall-related injuries are common in older adults, have negative effects both on quality of life and functional independence and are associated with increased morbidity, mortality and health care costs. Current clinical approaches and advice from falls guidelines vary substantially between countries and settings, warranting a standardised approach. At the first World Congress on Falls and Postural Instability in Kuala Lumpur, Malaysia, in December 2019, a worldwide task force of experts in falls in older adults, committed to achieving a global consensus on updating clinical practice guidelines for falls prevention and management by incorporating current and emerging evidence in falls research. Moreover, the importance of taking a person-centred approach and including perspectives from patients, caregivers and other stakeholders was recognised as important components of this endeavour. Finally, the need to specifically include recent developments in e-health was acknowledged, as well as the importance of addressing differences between settings and including developing countries. Methods a steering committee was assembled and 10 working Groups were created to provide preliminary evidence-based recommendations. A cross-cutting theme on patient's perspective was also created. In addition, a worldwide multidisciplinary group of experts and stakeholders, to review the proposed recommendations and to participate in a Delphi process to achieve consensus for the final recommendations, was brought together. Conclusion in this New Horizons article, the global challenges in falls prevention are depicted, the goals of the worldwide task force are summarised and the conceptual framework for development of a global falls prevention and management guideline is presented. [ABSTRACT FROM AUTHOR]

Published
2021
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38. Medication appropriateness on an acute geriatric care unit: the impact of the removal of a clinical pharmacist.

Author

Study, The Investigators of the MAGIC-PHARM, Khazaka, Michael, Laverdière, Jeanne, Li, Chen Chen, Correal, Florence, Mallet, Louise, Poitras, Mariane, and Nguyen, Patrick Viet-Quoc

Subjects
OCCUPATIONAL roles, LENGTH of stay in hospitals, HOSPITAL emergency services, CONFIDENCE intervals, PATIENT readmissions, REGRESSION analysis, TREATMENT effectiveness, PRE-tests & post-tests, CRITICAL care medicine, HOSPITAL wards, GROUP decision making, DESCRIPTIVE statistics, MEDICATION reconciliation, ELECTRONIC health records, ELDER care
Abstract

Background evidence is largely available indicating benefits to adding a pharmacist on acute care wards. The benefits of maintaining pharmacotherapeutic consultant services on a geriatric ward remain unexplored. Objectives to determine the impact of the removal of a clinical pharmacist from an acute geriatric ward on patients' Medication Appropriateness Index (MAI) scores, admission-related outcomes and drug burdens. Methods researchers consulted the archives for records of patients admitted to the geriatric care unit before and after the pharmacist's withdrawal. The primary outcome of differential MAI scores and secondary outcomes of rehospitalisations, emergency department visits, durations of hospitalisation and differential drug count were compared pre- and post-intervention. An interrupted time series analysis regression model was used for the primary outcome. Results a total of 305 patients admitted before (n  = 208) and after (n  = 97) the pharmacist's withdrawal were included in the study. The intervention had a significant impact on the primary outcome, increasing the relative differential MAI score (adjusted mean) by 9.3 points (95% confidence interval 3.9–14.6). As for the secondary outcomes, differences in admission-related outcomes were non-significant but the mean differential drug count significantly increased post-intervention from 0.02 to 1.36 (P  < 0.001). Conclusion the removal of the pharmacist led to an increase in inappropriate drug prescription. Careful consideration should be given to decisions regarding the removal of the pharmacist from acute geriatric care teams. [ABSTRACT FROM AUTHOR]

Published
2021
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40. Are your patients taking their medications correctly? If not, try this blueprint for success

Author

Segbefia, Iris Langevin and Mallet, Louise

Subjects
Drug therapy -- Management, Hospitals -- Admission and discharge, Health
Abstract

Nurses should educate patients before discharge about taking their medications correctly. The first step is understanding the prescription label, and here it may be necessary to involve the pharmacist. Keeping a record of the medication schedule is an essential part. The patient must be able to swallow the tablets, and any special needs relating to the medication should be checked on. This program should be modified to conform to the patient's needs.

Published
1997

42. Knowledge Translation Strategy to Reduce the Use of Potentially Inappropriate Medications in Hospitalized Elderly Adults

Author

Cossette, Benoit, primary, Bergeron, Josée, additional, Ricard, Geneviève, additional, Éthier, Jean-François, additional, Joly-Mischlich, Thomas, additional, Levine, Mitchell, additional, Sene, Modou, additional, Mallet, Louise, additional, Lanthier, Luc, additional, Payette, Hélène, additional, Rodrigue, Marie-Claude, additional, and Brazeau, Serge, additional

Published
2016
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47. The challenge of managing drug interactions in elderly people

Author

UCL - MD/FARM - Ecole de pharmacie, Mallet, Louise, Spinewine, Anne, Huang, Allen, UCL - MD/FARM - Ecole de pharmacie, Mallet, Louise, Spinewine, Anne, and Huang, Allen

Abstract

Drug therapy is essential when caring for elderly patients, but clearly it is a double-edged sword. Elderly patients are at high risk of having drug interactions, but the prevalence of these interactions is not well documented. Several types of interactions exist: drug-drug, drug-disease, drug-food, drug-alcohol, drug-herbal products, and drug-nutritional status. Factors such as age-related changes in pharmacokinetics and pharmacodynamics, frailty, interindividual variability, reduced homoeostatic mechanisms, and psychosocial issues need to be considered when drug interactions are assessed. Software can help clinicians to detect drug interactions, but many programmes have not been updated with the evolving knowledge of these interactions, and do not take into consideration important factors needed to optimise drug treatment in elderly patients. Any generated recommendations have to be tempered by a holistic, geriatric, multiprofessional approach that is team-based. This second paper in a series of two on prescribing in elderly people proposes an approach to categorise drug interactions, along with strategies to assist in their detection, management, and prevention.

Published
2007

48. Implementation of ward-based clinical pharmacy services in Belgium--description of the impact on a geriatric unit.

Author

UCL - MD/FARM - Ecole de pharmacie, UCL - MD/ESP - Ecole de santé publique, UCL - (SLuc) Service de gériatrie, UCL - (MGD) Service de médecine gériatrique, Spinewine, Anne, Dhillon, Soraya, Mallet, Louise, Tulkens, Paul M., Wilmotte, Léon, Swine, Christian, UCL - MD/FARM - Ecole de pharmacie, UCL - MD/ESP - Ecole de santé publique, UCL - (SLuc) Service de gériatrie, UCL - (MGD) Service de médecine gériatrique, Spinewine, Anne, Dhillon, Soraya, Mallet, Louise, Tulkens, Paul M., Wilmotte, Léon, and Swine, Christian

Abstract

BACKGROUND: Patient-centered clinical pharmacy services are still poorly developed in Europe, despite their demonstrated advantages in North America and the UK. Reporting European pilot experiences is, therefore, important to assess the usefulness of clinical pharmacy services in this specific context. OBJECTIVE: To report the results of the first implementation of Belgian clinical pharmacy services targeting patients at high risk of drug-related problems. METHODS: An intervention study was conducted by a trained clinical pharmacist providing pharmaceutical care to 101 patients (mean age 82.2 y; mean +/- SD number of prescribed drugs 7.8 +/- 3.5) admitted to an acute geriatric unit, over a 7 month period. All interventions to optimize prescribing, and their acceptance, were recorded. An external panel (2 geriatricians, 1 clinical pharmacist) assessed the interventions' clinical significance. Persistence of interventions after discharge was assessed through telephone calls. RESULTS: A total of 1066 interventions were made over the 7 month period. The most frequent drug-related problems underlying interventions were: underuse (15.9%), wrong dose (11.9%), inappropriate duration of therapy (9.7%), and inappropriate choice of medicine (9.6%). The most prevalent consequences were to discontinue a drug (24.5%), add a drug (18.6%), and change dosage (13.7%). Acceptance rate by physicians was 87.8%. Among interventions with clinical impact, 68.3% and 28.6% had moderate and major clinical significance, respectively. Persistence of chronic treatment changes 3 months after discharge was 84%. CONCLUSIONS: Involving a trained clinical pharmacist in a geriatric team led to clinically relevant and well-accepted optimization of medicine use. This initiative may be a springboard for further development of clinical pharmacy services.

Published
2006

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