Search

Your search keyword '"Malinova, Vesna"' showing total 250 results
Start Over Author "Malinova, Vesna"
250 results on '"Malinova, Vesna"'

10. Association of Fluid Balance and Hemoglobin Decline With Neurological Outcome After Aneurysmal Subarachnoid Hemorrhage

Author

Truckenmueller, Peter, Wolf, Stefan, Wasilewski, David, Vajkoczy, Peter, Früh, Anton, Baro, Norbert, Bauer, Miriam, Barner, Christoph, Dengler, Nora F., von Dincklage, Falk, Finger, Tobias, Francis, Roland, Hotter, Benjamin, Hunsicker, Oliver, Jussen, Daniel, Jüttler, Eric, Pohrt, Anne, Salih, Farid, Schaumann, Andreas, Witsch, Jens, Nagel, Christoph, Lemcke, Johannes, Meier, Ullrich, Podlesik, Dino, Schackert, Gabriele, Juratli, Tareq A., Huttner, Hagen, Schwab, Stefan, Staykov, Dimitre, Hagedorn, Sabine, Müller, Daniela, Müller, Oliver, Sarge, Robert, Sure, Ulrich, Bardutzky, Jürgen, Niesen, Wolf-Dirk, Lange, Katharina, Malinova, Vesna, Mielke, Dorothee, Rohde, Veit, Päsler, Dennis, Reinhardt, Stephanie, Schroeder, Henry W.S., Czorlich, Patrick, Regelsberger, Jan, Sauvigny, Thomas, Westphal, Manfred, Ehlert, Angelika, Gremmer, Rudolf, Beyer, Christian, Beyer, Desiree, Huthmann, Alexandra, Kerz, Thomas, Landscheidt, Julia, Schürer, Ludwig, Schul, David B., Meyer, Bernhard, Ryang, Yu-Mi, Toeroek, Elisabeth, Wostrack, Maria, Arouk, Wasim, Al-Jehani, Hosam, Fritsch, Michael, Al-Jehani, Hosam, Alturk, Abdulrahman Y., Sinclair, David B., Beck, Jürgen, Fung, Christian, Soell, Nicole, Engel, Doortje C., Hildebrandt, Gerhard, Huscher, Karen, Lange, Heidrun, Hutchinson, Peter, and Tseng, Ming-Yuan

Published
2024
Full Text
View/download PDF

12. Zerebrale Mikrodialyse

Author

Malinova, Vesna, von der Brelie, Christian, Harnisch, Lars-Olav, editor, Mörer, Onnen, editor, and Stephani, Caspar, editor

Published
2023
Full Text
View/download PDF

23. Ultrasound-Induced Release Profile of Nimodipine from Drug-Loaded Block Copolymers after Singular vs. Repeated Sonication: In Vitro Analysis in Artificial Cerebrospinal Fluid.

Author

Döring, Katja, Sperling, Swetlana, Ninkovic, Milena, Lanfermann, Heinrich, Streit, Frank, Fischer, Andreas, Rohde, Veit, and Malinova, Vesna

Subjects
CEREBROSPINAL fluid examination, BLOCK copolymers, SUBARACHNOID hemorrhage, CEREBRAL ischemia, CEREBROSPINAL fluid
Abstract

Objective: Nimodipine still represents a unique selling point in the prevention of delayed cerebral ischemia (DCI) following aneurysmal subarachnoid hemorrhage (aSAH). Its intrathecal effect is limited by a low oral bioavailability, leading to the development of nanocarrier systems to overcome this limitation. This study investigated the ultrasound-induced release profile of nimodipine from drug-loaded copolymers in artificial cerebrospinal fluid (CSF) within 72 h after a singular versus repeated sonication. Methods: Pluronic® F127 copolymers (Sigma-Aldrich, Taufkirchen, Germany)were loaded with nimodipine by direct dissolution. Spontaneous and on-demand drug release by ultrasound (1 MHz at 1.7 W/cm2) was determined in artificial cerebrospinal fluid using the dialysis bag method. Nimodipine concentrations were measured at predefined time points within 72 h of sonication. Results: Spontaneous release of nimodipine was enhanced by ultrasound application with significantly increased nimodipine concentrations two hours after a repeated sonication compared to a singular sonication (median 1.62 vs. 17.48 µg/µL, p = 0.04). A further trend was observed after four hours (median 1.82 vs. 22.09 µg/µL, p = 0.06). There was no difference in the overall nimodipine concentrations between the groups with a singular versus repeated sonication (357.2 vs. 540.3 µg/µL, p = 0.60) after 72 h. Conclusions: Repeated sonication resulted in an acceleration of nimodipine release from the drug-loaded copolymer in a CSF medium. These findings confirm the proof of principle of an on-demand guidance of nimodipine release from nimodipine-loaded nanodrugs by means of ultrasound, which suggests that evaluating the concept in an animal model may be appropriate. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

27. Benchmarking palliative care practices in neurooncology: a german perspective.

Author

Lawson McLean, Anna Cecilia, Lawson McLean, Aaron, Ernst, Thomas, Forster, Marie-Therese, Freyschlag, Christian, Gempt, Jens, Goldbrunner, Roland, Grau, Stefan, Jungk, Christine, van Oorschot, Birgitt, Rosahl, Steffen K., Wedding, Ulrich, Senft, Christian, Kamp, Marcel A., on behalf of the German Consortium for Excellence in Neurooncology, Palliative Care (GCE-NPC), Misch, Martin, Herrlinger, Ulrich, Malinova, Vesna, Machein, Marcia, and Hau, Peter

Abstract

Purpose: To benchmark palliative care practices in neurooncology centers across Germany, evaluating the variability in palliative care integration, timing, and involvement in tumor board discussions. This study aims to identify gaps in care and contribute to the discourse on optimal palliative care strategies. Methods: A survey targeting both German Cancer Society-certified and non-certified university neurooncology centers was conducted to explore palliative care frameworks and practices for neurooncological patients. The survey included questions on palliative care department availability, involvement in tumor boards, timing of palliative care integration, and use of standardized screening tools for assessing palliative burden and psycho-oncological distress. Results: Of 57 centers contacted, 46 responded (81% response rate). Results indicate a dedicated palliative care department in 76.1% of centers, with palliative specialists participating in tumor board discussions at 34.8% of centers. Variability was noted in the initiation of palliative care, with early integration at the diagnosis stage in only 30.4% of centers. The survey highlighted a significant lack of standardized spiritual care assessments and minimal use of advanced care planning. Discrepancies were observed in the documentation and treatment of palliative care symptoms and social complaints, underscoring the need for comprehensive care approaches. Conclusion: The study highlights a diverse landscape of palliative care provision within German neurooncology centers, underscoring the need for more standardized practices and early integration of palliative care. It suggests the necessity for standardized protocols and guidelines to enhance palliative care's quality and uniformity, ultimately improving patient-centered care in neurooncology. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

37. Infratentorial ganglioglioma mimicking a cerebellar metastasis.

Author

Komboz, Fares, Zechel, Sabrina, Malinova, Vesna, Mielke, Dorothee, Rohde, Veit, and Abboud, Tammam

Subjects
MAGNETIC resonance imaging, METASTASIS, DIFFERENTIAL diagnosis, LUNG cancer, BRAIN metastasis
Abstract

We report a case of an infratentorial ganglioglioma in a 56-year-old male, who underwent magnetic resonance imaging (MRI) during the diagnostic workup for a suspected lung cancer. The MRI scan revealed a space-occupying lesion of the left lobulus semilunaris superior cerebelli, which was assumed being a metastasis. The asymptomatic lesion was resected to establish the diagnosis. Histologic and immunohistochemical studies showed a ganglioglioma with World Health Organization grade I characteristics. Although ganglioglioma typically exhibits a supratentorial predilection, it should be included in the differential diagnosis of lesions occurring in the cerebellum. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

39. Optimizing the structure of interdisciplinary tumor boards for effective cancer care

Author

Braulke, Friederike, primary, Kober, Kathrin, additional, Arndt, Andreas, additional, Papendick, Maximilian, additional, Strauss, Arne, additional, Kramm, Christof Maria, additional, Thoms, Kai-Martin, additional, König, Alexander, additional, Gaedcke, Jochen, additional, Gallwas, Julia, additional, Wulf, Svenja, additional, Szuszies, Christoph, additional, Wulf, Gerald, additional, Rödel, Ralph, additional, Wolfer, Susanne, additional, Malinova, Vesna, additional, Overbeck, Tobias R., additional, Hinterthaner, Marc, additional, Lotz, Joachim, additional, Nauck, Friedemann, additional, Ernst, Marielle, additional, Stadelmann, Christine, additional, Ströbel, Philipp, additional, Ellenrieder, Volker, additional, Asendorf, Thomas, additional, and Rieken, Stefan, additional

Published
2023
Full Text
View/download PDF

40. Fight INflammation to Improve outcome after aneurysmal Subarachnoid HEmorRhage (FINISHER) trial: Study protocol for a randomized controlled trial

Author

Gueresir, Erdem, Lampmann, Tim, Bele, Sylvia, Czabanka, Marcus, Czorlich, Patrick, Gempt, Jens, Goldbrunner, Roland, Hurth, Helene, Hermann, Elvis, Jabbarli, Ramazan, Krauthausen, Marius, Koenig, Ralph, Lindner, Dirk, Malinova, Vesna, Meixensberger, Jurgen, Mielke, Dorothee, Nemeth, Robert, Oppong, Marvin Darkwah, Pala, Andrej, Prinz, Vincent, Rashidi, Ali, Roder, Constantin, Sandalcioglu, Ibrahim Erol, Sauvigny, Thomas, Schebesch, Karl-Michael, Timmer, Marco, Vajkoczy, Peter, Wessels, Lars, Wild, Florian, Wilhelm, Christoph, Wostrack, Maria, Vatter, Hartmut, Coch, Christoph, Gueresir, Erdem, Lampmann, Tim, Bele, Sylvia, Czabanka, Marcus, Czorlich, Patrick, Gempt, Jens, Goldbrunner, Roland, Hurth, Helene, Hermann, Elvis, Jabbarli, Ramazan, Krauthausen, Marius, Koenig, Ralph, Lindner, Dirk, Malinova, Vesna, Meixensberger, Jurgen, Mielke, Dorothee, Nemeth, Robert, Oppong, Marvin Darkwah, Pala, Andrej, Prinz, Vincent, Rashidi, Ali, Roder, Constantin, Sandalcioglu, Ibrahim Erol, Sauvigny, Thomas, Schebesch, Karl-Michael, Timmer, Marco, Vajkoczy, Peter, Wessels, Lars, Wild, Florian, Wilhelm, Christoph, Wostrack, Maria, Vatter, Hartmut, and Coch, Christoph

Abstract

Rationale: Aneurysmal subarachnoid hemorrhage (SAH) has high morbidity and mortality. While the primary injury results from the initial bleeding cannot currently be influenced, secondary injury through vasospasm and delayed cerebral ischemia worsens outcome and might be a target for interventions to improve outcome. To date, beside the aneurysm treatment to prevent re-bleeding and the administration of oral nimodipine, there is no therapy available, so novel treatment concepts are needed. Evidence suggests that inflammation contributes to delayed cerebral ischemia and poor outcome in SAH. Some studies suggest a beneficial effect of anti-inflammatory glucocorticoids, but there are no data from randomized controlled trials examining the efficacy of glucocorticoids. Therefore, current guidelines do not recommend the use of glucocorticoids in SAH. Aim: The Fight INflammation to Improve outcome after aneurysmal Subarachnoid HEmorRhage (FINISHER) trial aims to determine whether dexamethasone improves outcome in a clinically relevant endpoint in SAH patients. Methods and design: FINISHER is a multicenter, prospective, randomized, double-blinded, placebo-controlled clinical phase III trial which is testing the outcome and safety of anti-inflammatory treatment with dexamethasone in SAH patients. Sample size estimates: In all, 334 patients will be randomized to either dexamethasone or placebo within 48 h after SAH. The dexamethasone dose is 8 mg tds for days 1-7 and then 8 mg od for days 8-21. Study outcome: The primary outcome is the modified Rankin Scale (mRS) at 6 months, which is dichotomized to favorable (mRS 0-3) versus unfavorable (mRS 4-6). Discussion: The results of this study will provide the first phase III evidence as to whether dexamethasone improves outcome in SAH.

Published
2023

42. Effectiveness of Lumbar Cerebrospinal Fluid Drain Among Patients With Aneurysmal Subarachnoid Hemorrhage: A Randomized Clinical Trial

Author

Wolf, Stefan, Mielke, Dorothee, Barner, Christoph, Malinova, Vesna, Kerz, Thomas, Wostrack, Maria, Czorlich, Patrick, Salih, Farid, Engel, Doortje C, Ehlert, Angelika, Staykov, Dimitre, Alturki, Abdulrahman Y, Sure, Ulrich, Bardutzky, Jürgen, Schroeder, Henry W S, Schürer, Ludwig, Beck, Jürgen, Juratli, Tareq A, Fritsch, Michael, Lemcke, Johannes, Pohrt, Anne, Meyer, Bernhard, Schwab, Stefan, Rohde, Veit, and Vajkoczy, Peter

Subjects
610 Medicine & health
Abstract

IMPORTANCE After aneurysmal subarachnoid hemorrhage, the use of lumbar drains has been suggested to decrease the incidence of delayed cerebral ischemia and improve long-term outcome. OBJECTIVE To determine the effectiveness of early lumbar cerebrospinal fluid drainage added to standard of care in patients after aneurysmal subarachnoid hemorrhage. DESIGN, SETTING, AND PARTICIPANTS The EARLYDRAIN trial was a pragmatic, multicenter, parallel-group, open-label randomized clinical trial with blinded end point evaluation conducted at 19 centers in Germany, Switzerland, and Canada. The first patient entered January 31, 2011, and the last on January 24, 2016, after 307 randomizations. Follow-up was completed July 2016. Query and retrieval of data on missing items in the case report forms was completed in September 2020. A total of 20 randomizations were invalid, the main reason being lack of informed consent. No participants meeting all inclusion and exclusion criteria were excluded from the intention-to-treat analysis. Exclusion of patients was only performed in per-protocol sensitivity analysis. A total of 287 adult patients with acute aneurysmal subarachnoid hemorrhage of all clinical grades were analyzable. Aneurysm treatment with clipping or coiling was performed within 48 hours. INTERVENTION A total of 144 patients were randomized to receive an additional lumbar drain after aneurysm treatment and 143 patients to standard of care only. Early lumbar drainage with 5 mL per hour was started within 72 hours of the subarachnoid hemorrhage. MAIN OUTCOMES AND MEASURES Primary outcome was the rate of unfavorable outcome, defined as modified Rankin Scale score of 3 to 6 (range, 0 to 6), obtained by masked assessors 6 months after hemorrhage. RESULTS Of 287 included patients, 197 (68.6%) were female, and the median (IQR) age was 55 (48-63) years. Lumbar drainage started at a median (IQR) of day 2 (1-2) after aneurysmal subarachnoid hemorrhage. At 6 months, 47 patients (32.6%) in the lumbar drain group and 64 patients (44.8%) in the standard of care group had an unfavorable neurological outcome (risk ratio, 0.73; 95% CI, 0.52 to 0.98; absolute risk difference, -0.12; 95% CI, -0.23 to -0.01; P = .04). Patients treated with a lumbar drain had fewer secondary infarctions at discharge (41 patients [28.5%] vs 57 patients [39.9%]; risk ratio, 0.71; 95% CI, 0.49 to 0.99; absolute risk difference, -0.11; 95% CI, -0.22 to 0; P = .04). CONCLUSION AND RELEVANCE In this trial, prophylactic lumbar drainage after aneurysmal subarachnoid hemorrhage lessened the burden of secondary infarction and decreased the rate of unfavorable outcome at 6 months. These findings support the use of lumbar drains after aneurysmal subarachnoid hemorrhage. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT01258257.

Published
2023
Full Text
View/download PDF

46. Krankheitsspezifische und gesundheitsbezogene Lebensqualität nach fibrinolytischer Therapie bei spontaner intrazerebraler Hirnblutung

Author

Schwiddessen, Regina, Malinova, Vesna, von Steinbüchel-Rheinwall, Nicole, Hernández-Durán, Silvia, Mielke, Dorothee, Rohde, Veit, and von der Brelie, Christian

Subjects
ddc: 610, Medicine and health
Abstract

Objective: Spontaneous intracerebral haemorrhage (ICH) might have devastating consequences for all life dimensions. Outcome assessments frequently focus on physical impairment or mortality. This is the first study assessing disease-specific health-related quality of life (hrQoL) in order to better understand [for full text, please go to the a.m. URL]

Published
2022

47. Einfluss der Krankheitslast aufgrund von Komorbiditäten auf die Prognose von Patienten mit aneurysmatischer Subarachnoidalblutung

Author

Malinova, Vesna, Tuzi, Sheri, Kranawetter, Beate, Mörer, Onnen, Rohde, Veit, and Mielke, Dorothee

Subjects
ddc: 610, Medicine and health, cardiovascular diseases
Abstract

Objective: Several factors such as age and delayed cerebral ischemia (DCI) have been already identified as outcome determinants after aneurysmal subarachnoid hemorrhage (aSAH). In the last years, a growing evidence has evolved pointing out that aSAH should be rather regarded as a systemic disease affecting [for full text, please go to the a.m. URL]

Published
2022

48. Beitrag der Schnelligkeit der Volumenreduktion des Hämatoms auf die Effektivität der Lysetherapie und auf die Prognose der Patienten mit spontaner intrazerebraler Blutung

Author

Malinova, Vesna, Kranawetter, Beate, Schwiddessen, Regina, von der Brelie, Christian, Mielke, Dorothee, and Rohde, Veit

Subjects
ddc: 610, Medicine and health
Abstract

Objective: Intracerebral hemorrhage (ICH) is associated with high morbidity and mortality. Minimally invasive surgery (MIS) combined with tissue plasminogen activator (rtPA) fibrinolysis is considered a promising treatment option, however, a randomized trial failed to demonstrate a functional outcome [for full text, please go to the a.m. URL]

Published
2022
Full Text
View/download PDF

49. Der APACHE II Score ermöglicht eine präzise Vorhersage der Mortalität und des funktionellen Outcomes von Patienten mit supratentorieller intrazerebraler Hirnblutung und fibrinolytischer Therapie

Author

Schwiddessen, Regina, von der Brelie, Christian, Mielke, Dorothee, Rohde, Veit, and Malinova, Vesna

Subjects
ddc: 610, Medicine and health
Abstract

Objective: Spontaneous intracerebral haemorrhage (ICH) is associated with significant morbidity and mortality. In several studies no outcome benefit of surgical treatment could be demonstrated resulting into individual treatment decision-making. Especially, minimally invasive surgical treatments such [for full text, please go to the a.m. URL]

Published
2022

Catalog

Books, media, physical & digital resources
See catalog results