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12 results on '"Malinina, Alla"'

3. Genome-wide study identifies two loci associated with lung function decline in mild to moderate COPD

Author

Hansel, Nadia N., Ruczinski, Ingo, Rafaels, Nicholas, Sin, Don D., Daley, Denise, Malinina, Alla, Huang, Lili, Sandford, Andrew, Murray, Tanda, Kim, Yoonhee, Vergara, Candelaria, Heckbert, Susan R., Psaty, Bruce M., Li, Guo, Elliott, W. Mark, Aminuddin, Farzian, Dupuis, Josée, O’Connor, George T., Doheny, Kimberly, Scott, Alan F., Boezen, H. Marike, Postma, Dirkje S., Smolonska, Joanna, Zanen, Pieter, Mohamed Hoesein, Firdaus A., de Koning, Harry J., Crystal, Ronald G., Tanaka, Toshiko, Ferrucci, Luigi, Silverman, Edwin, Wan, Emily, Vestbo, Jorgen, Lomas, David A., Connett, John, Wise, Robert A., Neptune, Enid R., Mathias, Rasika A., Paré, Peter D., Beaty, Terri H., and Barnes, Kathleen C.

Published
2013
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7. Activation of Keratinocyte Protein Kinase Cζ in Psoriasis Plaques

Author

Richard L. Eckert, Anthony A. Gaspari, Malinina Alla Anatolievna, April Deng, John P. Petrali, Lida Zheng, Rita Fishelevich, and Yuming Zhao

Subjects
Keratinocytes, Male, medicine.medical_treatment, Receptors, Antigen, T-Cell, chemical and pharmacologic phenomena, Dermatology, Biology, Biochemistry, Article, Cell Line, Antigens, CD1, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Psoriasis, medicine, Humans, RNA, Messenger, Protein kinase A, Molecular Biology, Protein kinase C, Cells, Cultured, Protein Kinase C, 030304 developmental biology, 0303 health sciences, Tumor Necrosis Factor-alpha, hemic and immune systems, Cell Biology, medicine.disease, Natural killer T cell, Enzyme Activation, Killer Cells, Natural, Cytokine, CD1D, biology.protein, Cancer research, Tumor necrosis factor alpha, Signal transduction, Antigens, CD1d, Signal Transduction
Abstract

PKCzeta (protein kinase C-zeta), a member of protein kinase C family, plays an important role in cell proliferation, differentiation, and apoptosis. It acts as a downstream molecule for TNF-alpha (tumor necrosis factor) signal transduction and also regulates the expression of CD1d, an HLA-class I-like molecule. The interaction of CD1d with natural killer T (NKT) cells has been shown to be important in their Th1 cytokine production in psoriasis. In this study, we examined PKCzeta in psoriasis in order to define its role in the pathogenesis of the disease. We found that T-cell receptor (TCR) V alpha24+ V beta11+ NKT cells and CD1d molecules within psoriatic skin were increased. Moreover, there was an associated increase in PKCzeta mRNA and protein expression with membrane translocation in psoriasis lesions compared to uninvolved skin. Furthermore, cultured keratinocytes exhibited increased PKCzeta activity and membrane translocation upon stimulation by TNF-alpha, a cytokine known to play an important role in the pathogenesis of psoriasis. These results implied that PKCzeta is an important transduction molecule downstream of TNF-alpha signaling and is associated with increased expression of CD1d that may enhance CD1d-NKT cell interactions in psoriasis lesions. This makes PKCzeta a tempting target for possible pharmacological intervention in modifying the downstream effects of TNF-alpha in psoriasis.

Published
2008

8. The Effects of Electronic Cigarette Emissions on Systemic Cotinine Levels, Weight and Postnatal Lung Growth in Neonatal Mice

Author

McGrath-Morrow, Sharon A., primary, Hayashi, Madoka, additional, Aherrera, Angela, additional, Lopez, Armando, additional, Malinina, Alla, additional, Collaco, Joseph M., additional, Neptune, Enid, additional, Klein, Jonathan D., additional, Winickoff, Jonathan P., additional, Breysse, Patrick, additional, Lazarus, Philip, additional, and Chen, Gang, additional

Published
2015
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9. Hepatocyte Growth Factor, a Determinant of Airspace Homeostasis in the Murine Lung

Author

Calvi, Carla, primary, Podowski, Megan, additional, Lopez-Mercado, Armando, additional, Metzger, Shana, additional, Misono, Kaori, additional, Malinina, Alla, additional, Dikeman, Dustin, additional, Poonyagariyon, Hataya, additional, Ynalvez, Leslie, additional, Derakhshandeh, Roshanak, additional, Le, Anne, additional, Merchant, Mark, additional, Schwall, Ralph, additional, and Neptune, Enid R., additional

Published
2013
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11. Genome-wide study identifies two loci associated with lung function decline in mild to moderate COPD

Author

Hansel, Nadia N., primary, Ruczinski, Ingo, additional, Rafaels, Nicholas, additional, Sin, Don D., additional, Daley, Denise, additional, Malinina, Alla, additional, Huang, Lili, additional, Sandford, Andrew, additional, Murray, Tanda, additional, Kim, Yoonhee, additional, Vergara, Candelaria, additional, Heckbert, Susan R., additional, Psaty, Bruce M., additional, Li, Guo, additional, Elliott, W. Mark, additional, Aminuddin, Farzian, additional, Dupuis, Josée, additional, O’Connor, George T., additional, Doheny, Kimberly, additional, Scott, Alan F., additional, Boezen, H. Marike, additional, Postma, Dirkje S., additional, Smolonska, Joanna, additional, Zanen, Pieter, additional, Mohamed Hoesein, Firdaus A., additional, de Koning, Harry J., additional, Crystal, Ronald G., additional, Tanaka, Toshiko, additional, Ferrucci, Luigi, additional, Silverman, Edwin, additional, Wan, Emily, additional, Vestbo, Jorgen, additional, Lomas, David A., additional, Connett, John, additional, Wise, Robert A., additional, Neptune, Enid R., additional, Mathias, Rasika A., additional, Paré, Peter D., additional, Beaty, Terri H., additional, and Barnes, Kathleen C., additional

Published
2012
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