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5. Deep learning in drug discovery: a futuristic modality to materialize the large datasets for cheminformatics

Author

Ali Raza, Talha Ali Chohan, Manal Buabeid, El-Shaima A. Arafa, Tahir Ali Chohan, Batool Fatima, Kishwar Sultana, Malik Saad Ullah, and Ghulam Murtaza

Subjects
Structural Biology, General Medicine, Molecular Biology
Abstract

Artificial intelligence (AI) development imitates the workings of the human brain to comprehend modern problems. The traditional approaches such as high throughput screening (HTS) and combinatorial chemistry are lengthy and expensive to the pharmaceutical industry as they can only handle a smaller dataset. Deep learning (DL) is a sophisticated AI method that uses a thorough comprehension of particular systems. The pharmaceutical industry is now adopting DL techniques to enhance the research and development process. Multi-oriented algorithms play a crucial role in the processing of QSAR analysis, de novo drug design, ADME evaluation, physicochemical analysis, preclinical development, followed by clinical trial data precision. In this study, we investigated the performance of several algorithms, including deep neural networks (DNN), convolutional neural networks (CNN) and multi-task learning (MTL), with the aim of generating high-quality, interpretable big and diverse databases for drug design and development. Studies have demonstrated that CNN, recurrent neural network and deep belief network are compatible, accurate and effective for the molecular description of pharmacodynamic properties. In Covid-19, existing pharmacological compounds has also been repurposed using DL models. In the absence of the Covid-19 vaccine, remdesivir and oseltamivir have been widely employed to treat severe SARS-CoV-2 infections. In conclusion, the results indicate the potential benefits of employing the DL strategies in the drug discovery process.Communicated by Ramaswamy H. Sarma.

Published
2022

6. The Spasmolytic, Bronchodilator, and Vasodilator Activities of Parmotrema perlatum Are Explained by Anti-Muscarinic and Calcium Antagonistic Mechanisms

Author

Musaddique Hussain, Hazoor Bakhsh, Shahzada Khurram Syed, Malik Saad Ullah, Ali M. Alqahtani, Taha Alqahtani, Afaf A. Aldahish, Talha Bin Emran, Kashif Ur Rehman, and Khalid Hussain Janbaz

Subjects
acute toxicity, spasmolytic, bronchodilator, vasodilator, Ca+2 antagonist, Parmotremaperlatum, Organic chemistry, QD241-441
Abstract

Parmotremaperlatum is traditionally used in different areas of Pakistan to treat gastrointestinal, respiratory, and vascular diseases. This study evaluates the underlying mechanisms for traditional uses of P. perlatum in diarrhea, asthma, and hypertension. In vitro pharmacological studies were conducted using isolated jejunum, trachea, and aortic preparations, while the cytotoxic study was conducted in mice. Crude extract of P. perlatum(Pp.Cr), comprising appreciable quantities of alkaloids and flavonoids, relaxed spontaneously contracting jejunum preparation, K+ (80 mM)-induced, and carbachol (1 µM)-induced jejunum contractions in a concentration-dependent manner similar to dicyclomine and dantrolene. Pp.Cr showed a rightward parallel shift of concentration-response curves (CRCs) of Cch after a non-parallel shift similarto dicyclomine and shifted CRCs of Ca+2 to rightward much likeverapamil and dantrolene, demonstrating the coexistence of antimuscarinic and Ca+2 antagonistic mechanism. Furthermore, Pp.Cr, dicyclomine, and dantrolene relaxed K+ (80 mM)-induced and Cch (1 µM)-induced tracheal contractions and shifted rightward CRCs of Cch similar to dicyclomine, signifying the dual blockade. Additionally, Pp.Cr also relaxed the K+ (80 mM)-induced and phenylephrine (1 µM)-induced aortic contraction, similarly to verapamil and dantrolene, suggesting Ca+2 channel antagonism. Here, we explored for the first time thespasmolytic and bronchodilator effects of Pp.Crand whether they maybe due to the dual blockade of Ca+2 channels and muscarinic receptors, while the vasodilator effect might be owing to Ca+2 antagonism. Our results provide the pharmacological evidence that P. perlatum could be a new potential therapeutic option to treat gastrointestinal, respiratory, and vascular diseases. Hence, there is a need for further research to explore bioactive constituent of P. perlatum as well as further investigation by suitable experimental models are required to further confirm the importance and usefulness of P. perlatum in diarrhea, asthma, and hypertension treatment.

Published
2021
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8. Contributors

Author

Amir Hossein Abdolghaffari, Anjana Adhikari-Devkota, Salman Ahmed, Reem Hasaballah Alhasani, Mohammed Alqarni, Norah A. Althobaiti, Renata de Sousa Alves, Rajeshwar K.K. Arya, Mohammad Hossein Asghari, Chundoo B. Azeemah, Joseph I. Azzopardi, Nawshin Baureek, Tapan Behl, Tarun Belwal, Amira Y. Benmelouka, Dhaka R. Bhandari, Dheeraj Bisht, Arti Bisht, Renald Blundell, Anna Blázovics, Hasna Bouhenni, Jacqueline Ramos Machado Braga, Meriem Chafaa, Sharmistha Chatterjee, Zunera Chauhdary, Xiuping Chen, Lei Chen, Ericsson Coy-Barrera, Abhishek K. Das, Hari P. Devkota, Prasanta Dey, Arasana Dhariwal, Sanaa Dilmar A., Koula Doukani, Sumit Durgapal, Daphne Désiré A.-L., Shahira M. Ezzat, Sajad Fakhri, Mohammad Hosein Farzaei, Joomun B. Fatimah-Tuz-Zohra, Aakriti Garg, Noyel Ghosh, Sumit Ghosh, Jalaj K. Gour, Daniel Cordeiro Gurgel, Shokoufeh Hassani, Uday Hossain, Subratty A. Hussein, Shabnoor Iqbal, Arvind Jantwal, Roberta Jeane Bezerra Jorge, Tanuj Joshi, Vijay Juyal, Rahul Kaldate, Gökçe Ş. Karatoprak, Arnab Karmakar, S. Khatoon Khadaroo, Haroon Khan, Abdul H. Khan, Ziyad Khan, Anoop Kumar, Prashant Kumar, Aadesh Kumar, Manish Kumar, Ankit Kumar, Jankee T. Laxmi, Devina Lobine, Meeajan M. Irfaan, Filippo Maggi, Nihal M. El Mahdy, Marwa M. Mahfouz, Mohamad Fawzi Mahomoodally, Ankita Mandal, Aline Diogo Marinho, Harikesh Maurya, Lingchao Miao, Milad Moloudizargari, Saeideh Momtaz, Ghulam Mujtaba Shah, Seyed Mohammad Nabavi, Nouzaifa Nabee, Francisco Assis Nogueira-Junior, Diana Célia Sousa Nunes-Pinheiro, Abhay K. Pandey, Kiran Patni, Pooja Patni, Lokesh Patni, Vinay Pratap, Govind Rajpal, Márcia Maria Vieira Ramos, Harvesh Kumar Rana, Mahendra Rana, Amita J. Rana, Shahid Rasool, Azhar Rasul, Akhtar Rasul, Elodie Rosette M. A.-L., Archana N. Sah, Mohamed A. Salem, Kasturi Sarkar, Ammar S.M. Selles, Muhammad Ajmal Shah, Shahid Shah, Ruchika Sharma, Parames C. Sil, Ana Sanches Silva, João Alison de Moraes Silveira, Amit Kumar Singh, Anita Singh, Manoj K. Singh, Sushil Kumar Singh, Laxman Singh, Leila Soudani, Ipek Süntar, Devesh Tewari, Nidhi Tiwari, Malik Saad Ullah, Hammad Ullah, Jyoti Upadhyay, Mirele da Silveira Vasconcelos, Sandeep Visvarma, Jianbo Xiao, Yixi Xie, Ömer F. Yakıncı, Li Yang, Toorabally B. Zaynab, Haolin Zhang, Francisco Rogênio da Silva Mendes, Dirce Fernandes de Melo, Paulo Carvalho de Paula, Luciana de Siqueira Oliveira, Felipe Domingos de Sousa, Tamiris de Fátima Goebel de Souza, and Juan M. Álvarez-Caballero

Published
2022

9. Propyl gallate

Author

Renald Blundell, Muhammad Ajmal Shah, Joseph I. Azzopardi, Shabnoor Iqbal, Malik Saad Ullah, and Shahid Rasool

Published
2022

12. The Spasmolytic, Bronchodilator, and Vasodilator Activities of Parmotrema perlatum Are Explained by Anti-Muscarinic and Calcium Antagonistic Mechanisms

Author

Khalid Hussain Janbaz, Shahzada Khurram Syed, Talha Bin Emran, Afaf A Aldahish, Taha Alqahtani, Ali Alqahtani, Hazoor Bakhsh, Musaddique Hussain, Malik Saad Ullah, and Kashif Ur Rehman

Subjects
Carbachol, Parmotrema perlatum, medicine.drug_class, bronchodilator, Vasodilator Agents, Pharmaceutical Science, Organic chemistry, Muscarinic Antagonists, Pharmacology, acute toxicity, Dicyclomine, Dantrolene, Article, Analytical Chemistry, Mice, QD241-441, Ca+2 antagonist, Bronchodilator, Drug Discovery, Muscarinic acetylcholine receptor, medicine, Toxicity Tests, Acute, Animals, Parmotremaperlatum, Physical and Theoretical Chemistry, Phenylephrine, vasodilator, Chromatography, High Pressure Liquid, Biological Products, spasmolytic, biology, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Parmeliaceae, Spectrum Analysis, Parasympatholytics, biology.organism_classification, Calcium Channel Blockers, Bronchodilator Agents, Chemistry (miscellaneous), Molecular Medicine, Verapamil, medicine.drug
Abstract

Parmotremaperlatum is traditionally used in different areas of Pakistan to treat gastrointestinal, respiratory, and vascular diseases. This study evaluates the underlying mechanisms for traditional uses of P. perlatum in diarrhea, asthma, and hypertension. In vitro pharmacological studies were conducted using isolated jejunum, trachea, and aortic preparations, while the cytotoxic study was conducted in mice. Crude extract of P. perlatum(Pp.Cr), comprising appreciable quantities of alkaloids and flavonoids, relaxed spontaneously contracting jejunum preparation, K+ (80 mM)-induced, and carbachol (1 µM)-induced jejunum contractions in a concentration-dependent manner similar to dicyclomine and dantrolene. Pp.Cr showed a rightward parallel shift of concentration-response curves (CRCs) of Cch after a non-parallel shift similarto dicyclomine and shifted CRCs of Ca+2 to rightward much likeverapamil and dantrolene, demonstrating the coexistence of antimuscarinic and Ca+2 antagonistic mechanism. Furthermore, Pp.Cr, dicyclomine, and dantrolene relaxed K+ (80 mM)-induced and Cch (1 µM)-induced tracheal contractions and shifted rightward CRCs of Cch similar to dicyclomine, signifying the dual blockade. Additionally, Pp.Cr also relaxed the K+ (80 mM)-induced and phenylephrine (1 µM)-induced aortic contraction, similarly to verapamil and dantrolene, suggesting Ca+2 channel antagonism. Here, we explored for the first time thespasmolytic and bronchodilator effects of Pp.Crand whether they maybe due to the dual blockade of Ca+2 channels and muscarinic receptors, while the vasodilator effect might be owing to Ca+2 antagonism. Our results provide the pharmacological evidence that P. perlatum could be a new potential therapeutic option to treat gastrointestinal, respiratory, and vascular diseases. Hence, there is a need for further research to explore bioactive constituent of P. perlatum as well as further investigation by suitable experimental models are required to further confirm the importance and usefulness of P. perlatum in diarrhea, asthma, and hypertension treatment.

Published
2021

14. Abstract 13628: Cardiovascular Toxicity Associated With Vascular Endothelial Growth Factor Receptor Inhibitors Use in Oncology: A Network Meta-Analysis of Phase 3 Clinical Trials

Author

malik, saad ullah, primary, Malik, Asad Ullah, additional, Ezeh, Ebubechukwu, additional, Kachynski, Yury, additional, Nwanwene, Kemnasom, additional, Akhigbe, Esiemoghie, additional, Hamilton, Mackenzie, additional, Quadri, Ameer, additional, Nogot, Russell, additional, Tirona, Maria Tria, additional, and Thompson, Ellen, additional

Published
2021
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15. Cardiac Arrhythmias and Mortality after Hematopoietic Stem Cell Transplant (HSCT): A Systematic Review and Meta-Analysis

Author

Malik, Saad Ullah, primary, Braunstein, Zachary, additional, Vasu, Sumithira, additional, Penza, Sam, additional, Saad, Ayman, additional, Denlinger, Nathan, additional, de Lima, Marcos J.G., additional, Vallakati, Ajay, additional, Baliga, Ragavendra, additional, Jaglowski, Samantha, additional, Brammer, Jonathan E., additional, and Addison, Daniel, additional

Published
2021
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16. Impact of Acquired Thrombocytopenia on Cardiovascular Outcomes in Patients With Coronary Artery Disease Undergoing Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis

Author

Ahsan, Muhammad Junaid, primary, Fazeel, Hafiz Muhammad, additional, Haque, Syed Mansur Ul, additional, Malik, Saad Ullah, additional, Latif, Azka, additional, Lateef, Noman, additional, Batool, Syeda Sabeeka, additional, Kousa, Omar, additional, Ahsan, Mohammad Zoraiz, additional, Anwer, Faiz, additional, Andukuri, Venkata, additional, and Smer, Aiman, additional

Published
2021
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20. Clove oil based co-surfactant free microemulsion of flurbiprofen: Improved solubility with ameliorated drug-induced gastritis

Author

Muhammad Umair, Tanzeem, Sajid, Asghar, Syed Haroon, Khalid, Muhammad, Asif, Malik Saad, Ullah, Ikram Ullah, Khan, Ikrima, Khalid, Syed Ali, Faran, Abdul, Rehman, Umar Farooq, Gohar, and Tanveer, Hussain

Subjects
Chemistry, Pharmaceutical, Anti-Inflammatory Agents, Non-Steroidal, Polysorbates, Water, Polyethylene Glycols, Rats, Drug Liberation, Surface-Active Agents, Flurbiprofen, Clove Oil, Gastritis, Animals, Emulsions, Particle Size
Abstract

Flurbiprofen, an NSAID, is a water insoluble drug that is also notorious for gastric irritation and inflammation. This study was aimed at using a natural gastrprotective oil as the internal phase to develop flurbiprofen micro emulsion (ME) to improve it solubility and ameliorate its gastric side effects. Upon screening of ME components for drug solubility, clove oil, tween 80 and transcutol were identified as the oil, surfactant and co surfactant, respectively, with higher flurbiprofen solubility. Pseudo-ternary phase diagrams revealed that the ME made with surfactant only and without co-surfactant displayed the similar ME region as made with the mixture of surfactant and co-surfactant. Furthermore, drug loaded oil was also used to draw pseudo-ternary phase diagram and a very little decrease in the ME region was observed. Therefore, co-surfactant free flurbiprofen loaded ME was developed to avoid side effects associated with the use of excessive surfactant quantities. ME were found to possess size in the range of 11-41 nm with PDI0.5 and a slightly negative charge. Conductivity, pH and refractive indices of the selected MEs were well in the range. Drug release studies indicated maximum drug release from MEs within 5 min. Analysis of the gastric mucosa of rats after oral administration of drug solution and drug loaded ME confirmed that clove oil based ME provided significant protection against the NSAIDs induced gastric damage.

Published
2020

24. Efficacy and Safety of Amlodipine in Preventing Myocardial Iron Overload in Patients with Transfusion-Dependent Thalassemia Major : A Systematic Review and Meta-Analysis

Author

Kashyap, Richi, primary, Ali, Muhammad Ashar, additional, Malik, Saad Ullah, additional, Khalid, Farhan, additional, Jaan, Ali, additional, Khalid, Awais, additional, Dar, Abdul Jabbar, additional, Khurshid, Qasim, additional, Neupane, Karun, additional, Haider, Mobeen Zaka, additional, Abdullah, Syed Maaz, additional, and Anwer, Faiz, additional

Published
2020
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25. Venous thromboembolism risk with contemporary lenalidomide‐based regimens despite thromboprophylaxis in multiple myeloma: A systematic review and meta‐analysis

Author

Chakraborty, Rajshekhar, primary, Bin Riaz, Irbaz, additional, Malik, Saad Ullah, additional, Marneni, Naimisha, additional, Mejia Garcia, Alex, additional, Anwer, Faiz, additional, Khorana, Alok A., additional, Rajkumar, S. Vincent, additional, Kumar, Shaji, additional, Murad, M. Hassan, additional, Wang, Zhen, additional, Khan, Safi U., additional, and Majhail, Navneet S., additional

Published
2020
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26. A SYSTEMATIC REVIEW AND META-ANALYSIS ON THE PROGNOSTIC VALUE OF RED CELL DISTRIBUTION WIDTH ON DEVELOPMENT OF CONTRAST INDUCED NEPHROPATHY IN CORONARY ARTERY DISEASE PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION

Author

Ahsan, Muhammad J., primary, Malik, Saad Ullah, additional, Kousa, Omar, additional, Fazeel, Hafiz Muhammad, additional, Javed, Nisma, additional, Tahseen, Sidra, additional, Latif, Azka, additional, Hashmi, Mydah, additional, Shaikh, Kashif, additional, Andukuri, Venkata, additional, and Holmberg, Mark, additional

Published
2020
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27. A SYSTEMATIC REVIEW AND META-ANALYSIS OF PROGNOSTIC SIGNIFICANCE OF ACQUIRED THROMBOCYTOPENIA AFTER PERCUTANEOUS CORONARY INTERVENTION ON IN-HOSPITAL AND 30-DAY CARDIOVASCULAR OUTCOMES IN CORONARY ARTERY DISEASE PATIENTS

Author

Ahsan, Muhammad J., primary, Fazeel, Hafiz Muhammad, additional, Lateef, Noman, additional, Malik, Saad Ullah, additional, Anwar, Anosha, additional, Hassan, Syeda, additional, Hassan, Muryum, additional, Latif, Azka, additional, Ullah, Muhammad Qudrat, additional, Ashraf, Aqsa, additional, Townley, Theresa, additional, and Koster, Nancy, additional

Published
2020
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31. Diet and Nutrition in Alzheimer’s Disease and Healthy Aging

Author

Adnan Amin, Muhammad Ajmal Shah, Malik Saad Ullah, Kamal Niaz, Ahmed Abdulahi Abdurahman, Muhammed Bule, and Shahid Shah

Subjects
chemistry.chemical_classification, Reactive oxygen species, Antioxidant, medicine.medical_treatment, Physiology, Disease, Metabolism, Degeneration (medical), Biology, medicine.disease, Nutrient, chemistry, medicine, Healthy aging, Alzheimer's disease
Abstract

According to UN report of the world aging, older people are those 60 years of age and over, though others defined those over 85 as “oldest old.” Aging is a complex and gradual process which involves degeneration of cells mainly due to cellular redox reactions that result in detrimental biochemical and genetic alterations. Studies have related the risk of age-related diseases with increased level of oxidants. Dietary polyphenols like flavonoids are strong antioxidant that acts through interacting with reactive oxygen species producing reactive metals. All organisms need organic and inorganic nutrients such as proteins, carbohydrates, lipids, vitamins, minerals, and water. These nutrients have a significant role in regular biological activities like metabolism, growth, and repair. Protein is the most essential among the three macronutrients (i.e. carbohydrates, protein, and fat) responsible for aging. Moreover, bioactive chemicals from plants are important, though not essential, and they have been referred to as “life span essential,” since they have beneficial effect in healthy aging. Therefore, dietary interventions along with avoiding risk factors will reduce the risk of age-related degenerative diseases and increase healthy life span among the elderly.

Published
2019

35. HSR19-108: A Meta-Analysis of Randomized Controlled Trials (RCTs) for Efficacy and Safety of Vascular Endothelial Growth Factor Tyrosine Kinase Inhibitors (VEGF-TKIs) Adjuvant Therapy in High-Risk Renal Cell Cancer (RCC)

Author

Riaz, Irbaz Bin, primary, Malik, Saad Ullah, additional, Husnain, Muhammad, additional, Ain Riaz Sipra, Qurat Ul, additional, Faridi, Warda, additional, Gondal, Farva R., additional, Ho, Thanh, additional, Yadav, Siddhartha, additional, Wang, Zhen, additional, and Kohli, Manish, additional

Published
2019
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37. Efficacy of Ibrutinib-Based Regimen in Chronic Lymphocytic Leukemia: A Systematic Review

Author

Sardar, Muhammad, primary, Malik, Saad ullah, additional, Khan, Ali, additional, Idrees, Muhammad, additional, Ahmad, Qistas, additional, Sohail, Chaudhry, additional, Naseer, Raza, additional, Amin, Saher, additional, McBride, Ali, additional, Abuzar, Muhammad, additional, Safdar, Ahmed, additional, Chakraborty, Rajshekhar, additional, Lee, Patrick, additional, Sharon, David, additional, and Anwer, Faiz, additional

Published
2019
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38. Significant Risk of Graft-versus-Host Disease with Exposure to Checkpoint Inhibitors before and after Allogeneic Transplantation

Author

Ijaz, Awais, primary, Khan, Ali Younas, additional, Malik, Saad Ullah, additional, Faridi, Warda, additional, Fraz, Muhammad Asad, additional, Usman, Muhammad, additional, Tariq, Muhammad Junaid, additional, Durer, Seren, additional, Durer, Ceren, additional, Russ, Atlantis, additional, Parr, Nadia Nunes Cavalcante, additional, Baig, Zeeshan, additional, Sagar, FNU, additional, Ali, Zeeshan, additional, McBride, Ali, additional, and Anwer, Faiz, additional

Published
2019
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40. Gene Therapy for Thalassemia and Sickle Cell Anemia Poses Acceptable Toxicity and Efficacy: Clinical Outcomes in Forty-Seven Cases

Author

Fazeel, Hafiz Muhammad, primary, Abu Zar, Muhammad, additional, Malik, Saad Ullah, additional, Kamal, Ahmad, additional, Malik, Mustafa Nadeem, additional, Hassan, Syed Shabee, additional, Batool, Syeda Sabeeka, additional, Durer, Ceren, additional, Durer, Seren, additional, Aslam, Shehroz, additional, Shafqat, Madeeha, additional, Ijaz, Faiqa, additional, Anwer, Faiz, additional, and Hashmi, Shahrukh K., additional

Published
2018
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41. Presentation Patterns and Management Strategies for Central Nervous System Involvement in Multiple Myeloma: A Systematic Review of Literature

Author

Jose, Jemin Aby, primary, Selene, Insija Ilyas, additional, Malik, Mustafa Nadeem, additional, Qureshi, Anum, additional, Rafae, Abdul, additional, Fazeel, Hafiz Muhammad, additional, Abu Zar, Muhammad, additional, Kamal, Ahmad, additional, Malik, Saad Ullah, additional, Durer, Ceren, additional, Durer, Seren, additional, Jamil, Faiza, additional, Shafqat, Madeeha, additional, Usman, Muhammad, additional, Mahdi, Giyth Mithim, additional, and Anwer, Faiz, additional

Published
2018
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43. Efficacy of Lenalidomide Based Three Drug Versus Two Drug Regimen for Relapsed Multiple Myeloma: A Systematic Review and Meta-Analysis of Randomized Trials

Author

Usman, Muhammad, primary, Faridi, Warda, additional, Fraz, Muhammad Asad, additional, Tariq, Muhammad Junaid, additional, Malik, Saad Ullah, additional, Sagar, Fnu, additional, Ijaz, Awais, additional, Hussain, Abid, additional, Ahmad, Malik Qistas, additional, Khalil, Muhammad Jahanzeb, additional, Khalid, Amna, additional, Lakhani, Midhat, additional, Durer, Ceren, additional, Durer, Seren, additional, and Anwer, Faiz, additional

Published
2018
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44. Pomalidomide Based Regimens for Treatment of Relapsed Multiple Myeloma: A Systematic Review and Meta-Analysis of Clinical Trials

Author

Mushtaq, Adeela, primary, Iftikhar, Ahmad, additional, Lakhani, Midhat, additional, Sagar, Fnu, additional, Kamal, Ahmad, additional, Zahid, Umar, additional, Hassan, Hamza, additional, Ali, Zeeshan, additional, Razzaq, Faryal, additional, Malik, Saad Ullah, additional, Hassan, Syeda Fatima, additional, Abu Zar, Muhammad, additional, Bilal Chaudhary, Mohammad, additional, Safdar, Ahmad, additional, Bakr, Mohamed Mokhtar, additional, and Anwer, Faiz, additional

Published
2018
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47. Role of Ibrutinib Based Regimen in Chronic Lymphocytic Leukemia

Author

Sardar, Muhammad, primary, Malik, Saad Ullah, additional, Khan, Ali Younas, additional, Sohail, Chaudhry Saad, additional, Ahmad, Malik Qistas, additional, Amin, Saher Nasir, additional, Chakraborty, Rajshekar, additional, McBride, Ali, additional, Azharuddin, Muhammad, additional, Sharon, David, additional, Lee, Patrick, additional, Faridi, Warda, additional, and Anwer, Faiz, additional

Published
2018
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48. Efficacy and Safety Profile of Novel Alkylators in Combination Regimens for Patients with Multiple Myeloma: A Review of Literature

Author

Aslam, Shehroz, primary, Riaz, Rida, additional, Rafae, Abdul, additional, Malik, Mustafa Nadeem, additional, Jose, Jemin Aby, additional, Shah, Zunairah, additional, Abu Zar, Muhammad, additional, Qureshi, Anum, additional, Kamal, Ahmad, additional, Ijaz, Awais, additional, Khan, Ali Younas, additional, Malik, Saad Ullah, additional, and Anwer, Faiz, additional

Published
2018
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49. Efficacy and Safety of Newer Targeted Immunotherapy for Multiple Myeloma

Author

Aslam, Shehroz, primary, Riaz, Rida, additional, Malik, Mustafa Nadeem, additional, Rafae, Abdul, additional, Faridi, Warda, additional, Malik, Saad Ullah, additional, Selene, Insija Ilyas, additional, Shah, Zunairah, additional, Sohail, Chaudhry Saad, additional, Mahfooz, Faisal, additional, Samuel, Sharoon, additional, Yasir, Muhammad, additional, and Anwer, Faiz, additional

Published
2018
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50. Efficacy and Safety of Daratumumab Based Regimens for Multiple Myeloma: A Systematic Review and Meta-Analysis

Author

Abu Zar, Muhammad, primary, Kamal, Ahmad, additional, Khan, Ali Younas, additional, Malik, Saad Ullah, additional, Malik, Mustafa Nadeem, additional, Rafae, Abdul, additional, Durer, Ceren, additional, Durer, Seren, additional, Selene, Insija Ilyas, additional, Qureshi, Anum, additional, Jose, Jemin Aby, additional, Fazeel, Hafiz Muhammad, additional, Shah, Zunairah, additional, Rehman, Muhammad Adil, additional, and Anwer, Faiz, additional

Published
2018
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