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231 results on '"Malik, Dharmender"'

42. Lead‑203 VMT‑α‑Neuroendocrine Tumor Scintigraphy: A Promising Theranostics Agent.

Author

Thakral, Parul, Sen, Ishita Barat, Das, Subha Shankar, Schultz, Michael K., Kumari, Jyotsna, C. B., Virupakshappa, and Malik, Dharmender

Subjects
RADIONUCLIDE imaging, SOMATOSTATIN receptors, NEUROENDOCRINE tumors, COMPANION diagnostics, PEPTIDES
Abstract

Targeted alpha therapy (TAT) using lead‑212 (Pb‑212)‑labeled peptides presents an attractive option for the treatment of metastatic neuroendocrine tumors (NETs). As Pb‑203 presents an accurate diagnostic surrogate to Pb‑212, imaging with Pb‑203‑labelled peptides can be an important prerequisite to assess the feasibility of TAT with Pb‑212‑labelled agents. Here, we present the imaging data of a patient with metastatic NET with Pb‑203 VMT‑α‑NET, a somatostatin receptor targeting agent, and demonstrate the matching distribution of Pb‑203 VMT‑α‑NET with Ga‑68 DOTANOC. [ABSTRACT FROM AUTHOR]

Published
2024
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43. Radioguided Surgery in Insulinoma Using 68Ga Labeled Exendin-4: a Case Report.

Author

Das, Subha Shankar, Thakral, Parul, Manda, Divya, CB, Virupakshappa, Malik, Dharmender, and Sen, Ishita

Abstract

Laparoscopic resection of tumor is often performed for benign and small insulinomas, or for those located in the body or tail of the pancreas. The precise preoperative and intraoperative localization of the insulinoma is critical to minimize the surgical intervention. Conventional imaging studies, i.e., MRI, CT, and endoscopic ultrasound have limited sensitivity due to the small size of the insulinomas. Angiography, intraarterial calcium stimulation, and venous sampling are invasive procedures with concomitant risk for complications. Exendin-4 PET/CT scan has shown to be of great value in preoperative localization of insulinomas. In the absence of the traditional gold standard, i.e., intraoperative ultrasound with manual palpation, in laparoscopic surgery, a simple enucleation procedure might not be possible. Gamma probe-assisted surgery is a new method of diagnosis and treatment which allows a small area of tissue to be identified and removed, while a large area of the organ or the system remains unaffected. We present a case of a 34-year-old man with clinical suspicion of insulinoma with negative conventional imaging and successful lesion localization with 68Ga-Exendin-4 PET/CT scan in the pancreatic body, who underwent laparoscopic enucleation of the lesion with the aid of a hand-held gamma detecting probe. [ABSTRACT FROM AUTHOR]

Published
2021
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