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11. PO-1870 Safe use of the AQURE – the new mobile accelerator for IOERT based on air kerma measurement

Author

Misiarz, A., primary, Walkiewicz, J., additional, Malesa, B., additional, Trzuskowski, J., additional, Kruszyna-Mochalska, M., additional, Pawałowski, B., additional, Urbański, B., additional, Adamczyk, B., additional, Ryczkowski, A., additional, Suchorska, W., additional, Mantaj, P., additional, Konstanty, E., additional, Krzymański, T., additional, and Malicki, J., additional

Published
2022
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13. Immunogene Therapy of Human Melanoma : Phase I/II Clinical Trial

Author

Mackiewicz, Andrzej, Kapcińska, M., Wiznerowicz, M., Malicki, J., Nawrocki, S., Nowak, J., Murawa, P., Sibilska, E., Kowalczyk, D., Lange, A., Hawley, R. C., Rose-John, S., Walden, Peter, editor, Trefzer, Uwe, editor, Sterry, Wolfram, editor, Farzaneh, Farzin, editor, and Zambon, Patricia, editor

Published
1998
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22. PO-1174: Results of a multinational clinical audit for prostate cancer radiotherapy: the IROCA project

Author

Lopes de Castro, C., primary, Fundowicz, M., additional, Roselló, A., additional, Jové, J., additional, Deantonio, L., additional, Aguiar, A., additional, Pisani, C., additional, Villà, S., additional, Boladeras, A., additional, Konstanty, E., additional, Kruszyna-Mochalska, M., additional, Milecki, P., additional, Jurado-Bruggeman, D., additional, Lencart, J., additional, Modolell, I., additional, Muñoz-Montplet, C., additional, Aliste, L., additional, Torras, M.G., additional, Puigdemont, M., additional, Carvalho, L., additional, Krengli, M., additional, Guedea, F., additional, and Malicki, J., additional

Published
2020
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26. PD-0431: Multicentre clinical radiotherapy audit in rectal cancer: results of the IROCA project

Author

Fundowicz, M., primary, Aguiar, A., additional, de Castro, C. Lopes, additional, Torras, M.G., additional, Deantonio, L., additional, Konstanty, E., additional, Mochalska, M. Kruszyna, additional, Macia, M., additional, Canals, E., additional, Caro, M., additional, Pisani, C., additional, Zwierzchowska, D., additional, Molero, J., additional, Eraso, A., additional, Lencart, J., additional, Muñoz-Montplet, C., additional, Carvalho, L., additional, Krengli, M., additional, Malicki, J., additional, and Guedea, F., additional

Published
2020
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27. A transgenic zebrafish model for thein vivostudy of the blood and choroid plexus brain barriers usingclaudin 5

Author

van Leeuwen, L.M., Evans, R.J., Jim, K.K., Verboom, T., Fang, X., Bojarczuk, A., Malicki, J., Johnston, S.A., and van der Sar, A.M.

Abstract

The central nervous system (CNS) has specific barriers that protect the brain from potential threats and tightly regulate molecular transport. Despite the critical functions of the CNS barriers, the mechanisms underlying their development and function are not well understood, and there are very limited experimental models for their study. Claudin 5 is a tight junction protein required for blood brain barrier (BBB) and, probably, choroid plexus (CP) structure and function in vertebrates. Here, we show that the geneclaudin 5ais the zebrafish orthologue with high fidelity expression, in the BBB and CP barriers, that demonstrates the conservation of the BBB and CP between humans and zebrafish. Expression ofclaudin 5acorrelates with developmental tightening of the BBB and is restricted to a subset of the brain vasculature clearly delineating the BBB. We show thatclaudin 5a-expressing cells of the CP are ciliated ependymal cells that drive fluid flow in the brain ventricles. Finally, we find that CP development precedes BBB development and thatclaudin 5aexpression occurs simultaneously with angiogenesis. Thus, our novel transgenic zebrafish represents an ideal model to study CNS barrier development and function, critical in understanding the mechanisms underlying CNS barrier function in health and disease.

Published
2018

33. Does CyberKnife improve dose distribution versus IMRT and VMAT on a linear accelerator in low-risk prostate cancer?

Author

Borowicz Dorota Maria, Skrobała Agnieszka, Kruszyna-Mochalska Marta, and Malicki Julian

Subjects
prostate carcinoma, stereotactic radiotherapy, intensity-modulated radiotherapy, cyberknife, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

Hypofractionated stereotactic body radiation therapy (SBRT) for prostate cancer (PCa) can be delivered with the robot-assisted CyberKnife (CK) system or on a linear accelerator using dynamic intensity-modulated radiotherapy (IMRT) or volumetric arc radiotherapy (VMAT). This retrospective study was performed to determine whether CK offers better dose distribution than IMRT and/or VMAT.

Published
2022
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36. Kinesin-2 family motors in the unusual photoreceptor cilium

Author

Malicki, J. and Besharse, J.C.

Subjects
animal structures, sense organs
Abstract

This review focuses on recent advances in the understanding of kinesin-2 family motors in vertebrate photoreceptor development. Zebrafish photoreceptors develop by the 3rd day of embryogenesis, making it possible to study mutant phenotypes without the use of conditional alleles. Recent work using a zebrafish kif3b mutant allele validates the concept that the heterotrimeric kinesin II motor is generally required for ciliogenesis. In zebrafish photoreceptors, however, loss of kif3b function delays but does not block cilium formation. This is thought to occur because both kif3b or kif3c can dimerize with kif3a and function redundantly. The second ciliary kinesin thought to function in photoreceptor cells is kif17. Prior work has shown that either morpholino knockdown of this gene or the overexpression of its dominant negative form can reduce or delay photoreceptor cilium development without any evident impact on ciliogenesis in general. This has led to the idea that kif17 may play an important role only in some specialized cilium types, such the one in photoreceptor cells. In a recently identified kif17 mutant, however, photoreceptor outer segments are formed by 5 dpf and an obvious delay of outer segment formation is seen only at the earliest stage analyzed (3 dpf). This work suggests that kif17 plays a significant role mainly at an early stage of photoreceptor development. Taken together, these studies lead to an intriguing concept that as they differentiate photoreceptors alter their kinesin repertoire.

Published
2012

37. The Role of Glypicans in Wnt Inhibitory Factor-1 Activity and the Structural Basis of Wif1's Effects on Wnt and Hedgehog Signaling

Author

Avanesov, A., Honeyager, S. M., Malicki, J., and Blair, S. S.

Abstract

Proper assignment of cellular fates relies on correct interpretation of Wnt and Hedgehog (Hh) signals. Members of the Wnt Inhibitory Factor-1 (WIF1) family are secreted modulators of these extracellular signaling pathways. Vertebrate WIF1 binds Wnts and inhibits their signaling, but its Drosophila melanogaster ortholog Shifted (Shf) binds Hh and extends the range of Hh activity in the developing D. melanogaster wing. Shf activity is thought to depend on reinforcing interactions between Hh and glypican HSPGs. Using zebrafish embryos and the heterologous system provided by D. melanogaster wing, we report on the contribution of glypican HSPGs to the Wnt-inhibiting activity of zebrafish Wif1 and on the protein domains responsible for the differences in Wif1 and Shf specificity. We show that Wif1 strengthens interactions between Wnt and glypicans, modulating the biphasic action of glypicans towards Wnt inhibition; conversely, glypicans and the glypican-binding “EGF-like” domains of Wif1 are required for Wif1's full Wnt-inhibiting activity. Chimeric constructs between Wif1 and Shf were used to investigate their specificities for Wnt and Hh signaling. Full Wnt inhibition required the “WIF” domain of Wif1, and the HSPG-binding EGF-like domains of either Wif1 or Shf. Full promotion of Hh signaling requires both the EGF-like domains of Shf and the WIF domains of either Wif1 or Shf. That the Wif1 WIF domain can increase the Hh promoting activity of Shf's EGF domains suggests it is capable of interacting with Hh. In fact, full-length Wif1 affected distribution and signaling of Hh in D. melanogaster, albeit weakly, suggesting a possible role for Wif1 as a modulator of vertebrate Hh signaling.

Published
2012

43. Deep inspiration breath hold reduces the mean heart dose in left breast cancer radiotherapy

Author

Falco Michał, Masojć Bartłomiej, Macała Agnieszka, Łukowiak Magdalena, Woźniak Piotr, and Malicki Julian

Subjects
breast cancer, gated radiotherapy, deep inspiration breath hold, free breathing gated radiotherapy, mean heart dose, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

Patients with left breast cancer who undergo radiotherapy have a non-negligible risk of developing radiation-induced cardiovascular disease (CVD). Cardioprotection can be achieved through better treatment planning protocols and through respiratory gating techniques, including deep inspiration breath hold (DIBH). Several dosimetric studies have shown that DIBH reduces the cardiac dose, but clinical data confirming this effect is limited. The aim of the study was to compare the mean heart dose (MHD) in patients with left breast cancer who underwent radiotherapy at our institution as we transitioned from non-gated free-breathing (FB) radiotherapy to gated radiotherapy (FB-GRT), and finally to DIBH.

Published
2021
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44. Genetic defects of GDF6 in the zebrafish out of sight mutant and in human eye developmental anomalies.

Author

Hollander, A.I. den, Biyanwila, J., Kovach, P., Bardakjian, T., Traboulsi, E.I., Ragge, N.K., Schneider, A., Malicki, J., Hollander, A.I. den, Biyanwila, J., Kovach, P., Bardakjian, T., Traboulsi, E.I., Ragge, N.K., Schneider, A., and Malicki, J.

Abstract

Contains fulltext : 88522.pdf (publisher's version ) (Open Access), BACKGROUND: The size of the vertebrate eye and the retina is likely to be controlled at several stages of embryogenesis by mechanisms that affect cell cycle length as well as cell survival. A mutation in the zebrafish out of sight (out) locus results in a particularly severe reduction of eye size. The goal of this study is to characterize the outm233 mutant, and to determine whether mutations in the out gene cause microphthalmia in humans. RESULTS: In this study, we show that the severe reduction of eye size in the outm233 mutant is caused by a mutation in the zebrafish gdf6a gene. Despite the small eye size, the overall retinal architecture appears largely intact, and immunohistochemical studies confirm that all major cell types are present in outm233 retinae. Subtle cell fate and patterning changes are present predominantly in amacrine interneurons. Acridine orange and TUNEL staining reveal that the levels of apoptosis are abnormally high in outm233 mutant eyes during early neurogenesis. Mutation analysis of the GDF6 gene in 200 patients with microphthalmia revealed amino acid substitutions in four of them. In two patients additional skeletal defects were observed. CONCLUSIONS: This study confirms the essential role of GDF6 in the regulation of vertebrate eye size. The reduced eye size in the zebrafish outm233 mutant is likely to be caused by a transient wave of apoptosis at the onset of neurogenesis. Amino acid substitutions in GDF6 were detected in 4 (2%) of 200 patients with microphthalmia. In two patients different skeletal defects were also observed, suggesting pleitrophic effects of GDF6 variants. Parents carrying these variants are asymptomatic, suggesting that GDF6 sequence alterations are likely to contribute to the phenotype, but are not the sole cause of the disease. Variable expressivity and penetrance suggest a complex non-Mendelian inheritance pattern where other genetic factors may influence the outcome of the phenotype.

Published
2010

45. The apical complex couples cell fate and cell survival to cerebral cortical development.

Author

Kim, S., Lehtinen, M.K., Sessa, A., Zappaterra, M.W., Cho, S.H., Gonzalez, D., Boggan, B., Austin, C.A., Wijnholds, J., Gambello, M.J., Malicki, J., LaMantia, A.S., Broccoli, V., Walsh, C.A., Kim, S., Lehtinen, M.K., Sessa, A., Zappaterra, M.W., Cho, S.H., Gonzalez, D., Boggan, B., Austin, C.A., Wijnholds, J., Gambello, M.J., Malicki, J., LaMantia, A.S., Broccoli, V., and Walsh, C.A.

Published
2010

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