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21 results on '"Malibary,Husam"'

3. Effect of Nasal Continuous Airway Pressure With and Without Surfactant Administration for the Treatment of Respiratory Distress Syndrome in Preterm Neonates

Author

Malibary, Husam, primary, Nasief, Hisham, additional, Tamur, Shadi, additional, Ashfaq, Muhammad, additional, Iftikhar, Maria, additional, Naqoosh, Ayesha, additional, Khadawardi, Khalid, additional, Bahauddin, Ammar A, additional, Alzahrani, Ahmad, additional, and Hassan, Amber, additional

Published
2023
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5. Online case‐based learning for medical students as a teaching method for biochemistry at King Abdulaziz University amid COVID‐19 pandemic (a study conducted in 2021).

Author

Kubbara, Eman A., Ahmed, Nasreldin Marhoum, Alamri, Turki, Bakarman, Marwan A., Malibary, Husam, Eid, Rasha, and Alzahrani, Abdulrahman Omer

Subjects
MEDICAL students, COVID-19 pandemic, CASE-based reasoning, TEACHING methods, ONLINE education
Abstract

Online case‐based learning (CBL) is a method used by King Abdulaziz University to teach medical students in their preclinical years. The use of CBL in basic sciences is important for enabling medical students to correlate basic sciences with future clinical practice. This study implemented online CBL for biochemistry teaching as part of the medical genetic module for 3rd‐year preclinical students. Teaching during the study was completely online because of restricted precautions caused by the COVID‐19 pandemic, except for practical sessions that were held on campus. The case was presented to the students involved in prenatal screening and diagnosis. Students were guided to learn and discuss the biochemical tests used for prenatal screening and diagnosis and their clinical importance. They were divided into two groups: the control group was given an online lecture and the intervention group was given an online CBL session before the lecture. The online lecture was given to both groups simultaneously by the same instructor, and then 10 MCQs tests were distributed to both groups after the lecture, and their test scores were compared. A 10‐question survey was administered to the intervention group to assess their perception of the online CBL session after the test. A significant difference was found between the intervention and control groups regarding test scores (p < 0.001), and most students found the online CBL session enjoyable and motivating. [ABSTRACT FROM AUTHOR]

Published
2024
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6. The Cancer Driver Genes IDH1 and IDH2 and CD204 in WHO-Grade 4 Astrocytoma: Crosstalk Between Cancer Metabolism and Tumour Associated Macrophage Recruitment in Tumour Microenvironment

Author

Kurdi,Maher, Mulla,Nasser, Katib,Yousef, Alsinani,Taghreed, Hakamy,Sahar, MJ Addas,Bassam, Malibary,Husam, Halawa,Taher F, S Farhan,Marwa, Faizo,Eyad, Baeesa,Saleh, Kurdi,Maher, Mulla,Nasser, Katib,Yousef, Alsinani,Taghreed, Hakamy,Sahar, MJ Addas,Bassam, Malibary,Husam, Halawa,Taher F, S Farhan,Marwa, Faizo,Eyad, and Baeesa,Saleh

Abstract

Maher Kurdi,1,2 Nasser Mulla,3 Yousef Katib,4 Taghreed Alsinani,5 Sahar Hakamy,2 Bassam MJ Addas,6 Husam Malibary,7 Taher F Halawa,8 Marwa S Farhan,9 Eyad Faizo,10 Saleh Baeesa6 1Department of Pathology, Faculty of Medicine, King Abdulaziz University, Rabigh, Saudi Arabia; 2Brain Tumour Unit, KFMRC, King Abdulaziz University, Jeddah, Saudi Arabia; 3Department of Internal Medicine, Faculty of Medicine, Taibah University, Medina, Saudi Arabia; 4Department of Radiology, Faculty of Medicine, Taibah University, Madinah, Saudi Arabia; 5Department of Surgery, King Fahad General Hospital, Jeddah, Saudi Arabia; 6Department of Surgery, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia; 7Department of Internal Medicine, Faculty of Medicine, King Abdul Aziz University, Jeddah, Saudi Arabia; 8Pediatric Hematology and Oncology Consultant, Faculty of Medicine, King Abdulaziz University, Rabigh, Saudi Arabia; 9Clinical Pathology Department, Cairo University, Cairo, Egypt; 10Division of Neurosurgery, Department of Surgery, Faculty of Medicine, Tabuk University, Tabuk, Saudi ArabiaCorrespondence: Maher Kurdi, Department of Pathology, Faculty of Medicine, King Abdulaziz University, Rabigh, Saudi Arabia, Tel +966 556655467, Email Ahkurdi@kau.edu.saPurpose: IDH1 and IDH2 are hotspot mutations commonly identified in WHO-grade 4 astrocytomas. Their association with TAMs has never been investigated. We aim to explore the crosstalk between the IDH1/2 mutation metabolic effect and TAMs in tumour microenvironment and how this relationship affects the tumour recurrence.Patients and Methods: The study included 20 samples of patients with WHO-grade 4 astrocytoma. The alteration hotspot in codon IDH1R132 and IDH2R172 was examined using direct sequencing. The protein expression of CD204 on TAM was detected through immunohistochemistry.Results: IDH1R132 and IDH2R172 were symmetrically identified as wildtype in 18/20 tumours (90%) and the remaining 2 tumours (10%) showed synonymou

Published
2023

8. The Cancer Driver Genes IDH1 and IDH2 and CD204 in WHO-Grade 4 Astrocytoma: Crosstalk Between Cancer Metabolism and Tumour Associated Macrophage Recruitment in Tumour Microenvironment

Author

Kurdi, Maher, primary, Mulla, Nasser, additional, Katib, Yousef, additional, Alsinani, Taghreed, additional, Hakamy, Sahar, additional, MJ Addas, Bassam, additional, Malibary, Husam, additional, Halawa, Taher F, additional, S Farhan, Marwa, additional, Faizo, Eyad, additional, and Baeesa, Saleh, additional

Published
2023
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13. The Expression of Sodium Channel Alpha Subunit (Nav1.7) Receptors in Intracranial Meningioma and Its Comparison to Urothelial, Prostate and Ovarian Cancers

Author

Mehboob, Riffat, primary, Kurdi, Maher, additional, Baeesa, Saleh, additional, Bahakeem, Basem, additional, Alkhayyat, Shadi, additional, Maghrabi, Yazid, additional, Bardeesi, Anas, additional, Saeedi, Rothaina, additional, Ashghar, Mowadah, additional, Hakamy, Sahar, additional, and Malibary, Husam, additional

Published
2021
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15. Comprehensive Analysis of Genes Associated With Sudden Infant Death Syndrome

Author

Mehboob, Riffat, primary, Kurdi, Maher, additional, Ahmad, Mursleen, additional, Gilani, Syed Amir, additional, Khalid, Sidra, additional, Nasief, Hisham, additional, Mirdad, Abeer, additional, Malibary, Husam, additional, Hakamy, Sahar, additional, Hassan, Amber, additional, Alaifan, Meshari, additional, Bamaga, Ahmed, additional, and Shahzad, Syed Adnan, additional

Published
2021
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17. Comprehensive Analysis of Genes Associated With Sudden Infant Death Syndrome

Author

Mehboob, Riffat, Kurdi, Maher, Ahmad, Mursleen, Gilani, Syed Amir, Khalid, Sidra, Nasief, Hisham, Mirdad, Abeer, Malibary, Husam, Hakamy, Sahar, Hassan, Amber, Alaifan, Meshari, Bamaga, Ahmed, Shahzad, Syed Adnan, Mehboob, Riffat, Kurdi, Maher, Ahmad, Mursleen, Gilani, Syed Amir, Khalid, Sidra, Nasief, Hisham, Mirdad, Abeer, Malibary, Husam, Hakamy, Sahar, Hassan, Amber, Alaifan, Meshari, Bamaga, Ahmed, and Shahzad, Syed Adnan

Abstract

Background: Sudden infant death syndrome (SIDS) is a tragic incident which remains a mystery even after post-mortem investigation and thorough researches. Methods: This comprehensive review is based on the genes reported in the molecular autopsy studies conducted on SIDS so far. A total of 20 original studies and 7 case reports were identified and included in this analysis. The genes identified in children or adults were not included. Most of the genes reported in these studies belonged to cardiac channel and cardiomyopathy. Cardiac channel genes in SIDS were scrutinized for further analysis. Results: After screening and removing the duplicates, 42 unique genes were extracted. When the location of these genes was assessed, it was observed that most of these belonged to Chromosomes 11, 1 and 3 in sequential manner. The pathway analysis shows that these genes are involved in the regulation of heart rate, action potential, cardiac muscle cell contraction and heart contraction. The protein-protein interaction network was also very big and highly interactive. SCN5A, CAV3, ALG10B, AKAP9 and many more were mainly found in these cases and were regulated by many transcription factors such as MYOG C2C1 and CBX3 HCT11. Micro RNA, hsa-miR-133a-3p was found to be prevalent in the targeted genes. Conclusions: Molecular and computational approaches are a step forward toward exploration of these sad demises. It is so far a new arena but seems promising to dig out the genetic cause of SIDS in the years to come.

Published
2021

18. Self-isolation during the COVID-19 pandemic is associated with increased risk of burnout among physician trainees: A cross sectional study

Author

Farsi, Ali, primary, Alomar, Soha A, additional, Kadi, Mai, additional, Farsi, Sara, additional, Algethamy, Haifa, additional, Reda, Bashar, additional, Bahaidarah, Saud A, additional, Binmahfouz, Alya, additional, Nassif, Mohammed O, additional, Samkari, Ali, additional, Qutub, Majdy M, additional, Alnoury, Ibrahim, additional, Malibary, Husam, additional, Bakhsh, Abdullah, additional, ljaaly, Hattan A, additional, Alsayyed, Ehab, additional, Akeel, Nouf, additional, Alghamdi, Waleed, additional, hamdi (13) Abdulaziz Saleem, Abdulaziz, additional, Malibary, Nadim, additional, Baghlaf, Omar, additional, and Trabulsi, Nora, additional

Published
2021
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21. The Cancer Driver Genes IDH1 and IDH2 and CD204 in WHO-Grade 4 Astrocytoma: Crosstalk Between Cancer Metabolism and Tumour Associated Macrophage Recruitment in Tumour Microenvironment.

Author

Kurdi M, Mulla N, Katib Y, Alsinani T, Hakamy S, Mj Addas B, Malibary H, Halawa TF, S Farhan M, Faizo E, and Baeesa S

Abstract

Purpose: IDH1 and IDH2 are hotspot mutations commonly identified in WHO-grade 4 astrocytomas. Their association with TAMs has never been investigated. We aim to explore the crosstalk between the IDH1/2 mutation metabolic effect and TAMs in tumour microenvironment and how this relationship affects the tumour recurrence., Patients and Methods: The study included 20 samples of patients with WHO-grade 4 astrocytoma. The alteration hotspot in codon IDH1 R132 and IDH2 R172 was examined using direct sequencing. The protein expression of CD204 on TAM was detected through immunohistochemistry., Results: IDH1 R132 and IDH2 R172 were symmetrically identified as wildtype in 18/20 tumours (90%) and the remaining 2 tumours (10%) showed synonymous mutations on both codons. Tumours with IDH1/2-wildtype showed high expression of CD204 + TAMs in 10 cases and low expression in 8 cases. Typical expression was seen equally in IDH1/2 mutant tumours. There was no significant association between IDH1/2 and CD204 + TAM expression (p= 0.999). The association between the two groups was significantly observed among IDH-wildtype tumours (p=0.027). Highly expressed CD204 in IDH-wildtype tumours showed a median recurrence at 10 months compared to low CD204 expression, showed a median recurrence interval at 24 months., Conclusion: IDH1 R132 or IDH R172 has the same impact on the classification and prognosis of WHO-grade 4 astrocytoma. There was no crosstalk between IDH1/2 metabolic effect and CD204 + TAM. However, IDH-wildtype glioblastomas with dense CD204 + TAM are associated with early recurrence. Because the sample size is small, a larger study is recommended to determine the impact of IDH1/2 on TAMs., Competing Interests: The authors report no conflicts of interest in this work., (© 2023 Kurdi et al.)

Published
2023
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